Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HYDIN	54768	broad.mit.edu	37	16	70867977	70867977	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:70867977G>A	ENST00000393567.2	-	79	13642	c.13492C>T	c.(13492-13494)Cct>Tct	p.P4498S		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	4498										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GAGAAGGGAGGGACACGCTTC	0.557000													6	32					0	0	0.001984	0	0
NEU4	129807	broad.mit.edu	37	2	242756232	242756232	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:242756232C>T	ENST00000391969.2	+	4	1056	c.345C>T	c.(343-345)atC>atT	p.I115I	NEU4_ENST00000405370.1_Silent_p.I115I|NEU4_ENST00000407683.1_Silent_p.I115I|NEU4_ENST00000325935.6_Silent_p.I128I|NEU4_ENST00000404257.1_Silent_p.I127I	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	115						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CCGTGCAGATCGCCACGGGAA	0.701000													4	3					0	0	0.009096	0	0
HTRA1	5654	broad.mit.edu	37	10	124249077	124249077	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:124249077T>C	ENST00000368984.3	+	3	840	c.712T>C	c.(712-714)Tac>Cac	p.Y238H		NM_002775.4	NP_002766.1	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1	238	Serine protease.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(8)|lung(7)	17		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				CGGTGCCACTTACGAAGCCAA	0.498000													23	46					0	0	0.014323	0	0
PAPL	390928	broad.mit.edu	37	19	39591408	39591408	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:39591408C>T	ENST00000331256.5	+	7	996	c.722C>T	c.(721-723)tCc>tTc	p.S241F	PAPL_ENST00000594229.1_Missense_Mutation_p.P200S	NM_001004318.2	NP_001004318.2	Q6ZNF0	PAPL_HUMAN		241						extracellular region	acid phosphatase activity|metal ion binding										CACATCATCTCCTTCTCCACC	0.607000													23	41					0	0	0.004656	0	0
GALNTL6	442117	broad.mit.edu	37	4	173150813	173150813	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:173150813C>T	ENST00000506823.1	+	3	802	c.145C>T	c.(145-147)Cca>Tca	p.P49S	GALNTL6_ENST00000508122.1_Missense_Mutation_p.P32S	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	49						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						ACAGACATTTCCACTGGGCCT	0.433000													16	33					0	0	0.003163	0	0
B3GNTL1	146712	broad.mit.edu	37	17	80918991	80918991	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:80918991C>T	ENST00000576599.1	-	8	1084	c.334G>A	c.(334-336)Gac>Aac	p.D112N	B3GNTL1_ENST00000320865.3_Missense_Mutation_p.D223N|B3GNTL1_ENST00000571954.1_5'UTR			Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	223							transferase activity, transferring glycosyl groups			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	8	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			AGACTCTGGTCCACGCGGATG	0.697000													18	22					0	0	0.007413	0	0
ZNF425	155054	broad.mit.edu	37	7	148802070	148802070	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:148802070C>T	ENST00000378061.2	-	4	1025	c.893G>A	c.(892-894)gGg>gAg	p.G298E		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	298					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CGGCCGCTCCCCGCGGTGTAG	0.667000													13	28					0	0	0.013537	0	0
SLC27A6	28965	broad.mit.edu	37	5	128302184	128302184	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:128302184C>T	ENST00000262462.4	+	1	1364	c.354C>T	c.(352-354)ttC>ttT	p.F118F	SLC27A6_ENST00000506176.1_Silent_p.F118F|SLC27A6_ENST00000395266.1_Silent_p.F118F			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	118					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGCCGGACTTCGTTCACGTGT	0.567000													9	45					0	0	0.006214	0	0
ZPBP2	124626	broad.mit.edu	37	17	38027043	38027043	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:38027043G>A	ENST00000377940.3	+	2	288	c.149G>A	c.(148-150)tGg>tAg	p.W50*	ZPBP2_ENST00000584588.1_Nonsense_Mutation_p.W72*|ZPBP2_ENST00000348931.4_Nonsense_Mutation_p.W72*	NM_198844.2	NP_942141.2	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2	72					binding of sperm to zona pellucida	extracellular region				kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			ACCTACTTATGGATTGGGCCT	0.294000													34	55					0	0	0.007835	0	0
FSTL5	56884	broad.mit.edu	37	4	162306931	162306931	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:162306931C>T	ENST00000306100.5	-	16	2948	c.2512G>A	c.(2512-2514)Gga>Aga	p.G838R	FSTL5_ENST00000379164.4_Missense_Mutation_p.G837R|FSTL5_ENST00000427802.2_Missense_Mutation_p.G828R|FSTL5_ENST00000536695.1_Missense_Mutation_p.G837R|RP11-234O6.2_ENST00000508189.1_RNA	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	838						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ACTGTATTTCCTTTTTCAACT	0.358000													11	19					0	0	0.010729	0	0
SCN3A	6328	broad.mit.edu	37	2	165994396	165994396	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:165994396C>T	ENST00000360093.3	-	15	2875	c.2384G>A	c.(2383-2385)gGa>gAa	p.G795E	SCN3A_ENST00000283254.7_Missense_Mutation_p.G795E|SCN3A_ENST00000409101.3_Missense_Mutation_p.G746E	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	795						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TACCAGGTTTCCTACAGTCAA	0.398000													9	9					0	0	0.006214	0	0
AKR1D1	6718	broad.mit.edu	37	7	137792307	137792307	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:137792307G>A	ENST00000242375.3	+	7	878	c.836G>A	c.(835-837)aGg>aAg	p.R279K	AKR1D1_ENST00000468877.2_3'UTR|AKR1D1_ENST00000411726.2_Missense_Mutation_p.R238K|AKR1D1_ENST00000432161.1_Missense_Mutation_p.R279K	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	279					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						AATCTTGAAAGGATCAAAGAA	0.358000													20	54					0	0	0.008871	0	0
OR6C4	341418	broad.mit.edu	37	12	55945195	55945195	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:55945195G>A	ENST00000394256.2	+	1	213	c.185G>A	c.(184-186)cGg>cAg	p.R62Q	RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						TTCTTCCTCCGGAATTTCTCC	0.433000													9	37					0	0	0.008291	0	0
ME1	4199	broad.mit.edu	37	6	84061792	84061792	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:84061792A>T	ENST00000369705.3	-	4	545	c.429T>A	c.(427-429)gaT>gaA	p.D143E	ME1_ENST00000543031.1_Missense_Mutation_p.D68E|ME1_ENST00000541327.1_5'UTR	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	143					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	CCTTGATGACATCTTCTGGCC	0.318000													3	4					0	0	0.009096	0	0
CTNNA3	29119	broad.mit.edu	37	10	67829077	67829077	+	Silent	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:67829077T>G	ENST00000433211.1	-	15	2322	c.2148A>C	c.(2146-2148)acA>acC	p.T716T	CTNNA3_ENST00000373744.4_Silent_p.T716T|CTNNA3_ENST00000373735.1_Silent_p.T55T	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	716					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						TAGTGAAGTCTGTCATCTCCA	0.368000													24	54					0	0	0.018920	0	0
SULF1	23213	broad.mit.edu	37	8	70541836	70541836	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:70541836G>A	ENST00000260128.4	+	19	2923	c.2206G>A	c.(2206-2208)Ggg>Agg	p.G736R	SULF1_ENST00000402687.4_Missense_Mutation_p.G736R|SULF1_ENST00000458141.2_Missense_Mutation_p.G736R|SULF1_ENST00000419716.3_Missense_Mutation_p.G736R|SULF1_ENST00000521946.1_3'UTR	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	736					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GCAGAGGAAGGGGGAAGAGTG	0.537000													28	87					0	0	0.008361	0	0
THBS3	7059	broad.mit.edu	37	1	155167720	155167720	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:155167720C>T	ENST00000368378.3	-	19	2274		c.e19-1		RP11-263K19.4_ENST00000447623.1_RNA|THBS3_ENST00000487250.1_Splice_Site|THBS3_ENST00000541990.1_Splice_Site|THBS3_ENST00000541576.1_Splice_Site|THBS3_ENST00000457183.2_Splice_Site|THBS3_ENST00000428962.2_Splice_Site	NM_001252607.1|NM_007112.4	NP_001239536.1|NP_009043.1	P49746	TSP3_HUMAN	thrombospondin 3						cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TTTCCATGCCCTGGGGTTGTA	0.517000													15	82					0	0	0.020292	0	0
SLC5A8	160728	broad.mit.edu	37	12	101581199	101581199	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:101581199G>A	ENST00000536262.2	-	7	1486	c.928C>T	c.(928-930)Cct>Tct	p.P310S		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	310					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GCTGTCCAAGGATCACAGTCA	0.438000													4	16					0	0	0.014758	0	0
DSG4	147409	broad.mit.edu	37	18	28993144	28993144	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:28993144G>A	ENST00000359747.4	+	15	2795	c.2766G>A	c.(2764-2766)ggG>ggA	p.G922G	RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Silent_p.G903G	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	903					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGGTCCATGGGGATATTATTG	0.428000													31	97					0	0	0.013726	0	0
UGT2B17	7367	broad.mit.edu	37	4	69403409	69403409	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:69403409G>A	ENST00000317746.2	-	6	1569	c.1527C>T	c.(1525-1527)atC>atT	p.I509I		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	509					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						AACATTTTGTGATCATAAATA	0.443000													26	16					0	0	0.018920	0	0
SEC31B	25956	broad.mit.edu	37	10	102249886	102249886	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:102249886G>A	ENST00000370345.3	-	21	2941	c.2844C>T	c.(2842-2844)ggC>ggT	p.G948G		NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	948	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		AGACCATGCGGCCGGGACCTA	0.622000													21	69					0	0	0.014323	0	0
DENND4A	10260	broad.mit.edu	37	15	66025116	66025116	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:66025116G>A	ENST00000443035.3	-	8	1296	c.1081C>T	c.(1081-1083)Cct>Tct	p.P361S	DENND4A_ENST00000431932.2_Missense_Mutation_p.P361S	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	361	DENN.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						GGTCTCTGAGGAGATGGAAAA	0.343000													6	21					0	0	0.001984	0	0
GDF2	2658	broad.mit.edu	37	10	48416646	48416646	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:48416646C>T	ENST00000249598.1	-	1	207	c.48G>A	c.(46-48)ctG>ctA	p.L16L		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	16					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						GGGAGCCAGCCAGCAGGGACA	0.682000													7	16					0	0	0.004482	0	0
ZNF248	57209	broad.mit.edu	37	10	38126603	38126603	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:38126603G>A	ENST00000395867.3	-	5	730	c.180C>T	c.(178-180)atC>atT	p.I60I	ZNF248_ENST00000494133.1_5'UTR|ZNF248_ENST00000374648.3_Silent_p.I60I|ZNF248_ENST00000357328.4_Silent_p.I60I	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	60	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.I60I(1)		NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						CTCCTTGCTCGATCTTAAAGA	0.428000													12	15					0	0	0.013537	0	0
PDK3	5165	broad.mit.edu	37	X	24521544	24521544	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:24521544C>T	ENST00000441463.2	+	4	421	c.421C>T	c.(421-423)Cct>Tct	p.P141S	PDK3_ENST00000379162.4_Missense_Mutation_p.P141S	NM_001142386.2	NP_001135858.1	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase, isozyme 3	141	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			NS(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TGGGTTTGATCCTTTCATTAG	0.378000													15	16					0	0	0.004007	0	0
ELAC2	60528	broad.mit.edu	37	17	12898087	12898087	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:12898087G>A	ENST00000338034.4	-	21	2262	c.2023C>T	c.(2023-2025)Cgg>Tgg	p.R675W	ELAC2_ENST00000426905.3_Missense_Mutation_p.R635W|ELAC2_ENST00000395962.2_Missense_Mutation_p.R656W	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2	675					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						TCACCCATCCGGACCAGAGCC	0.602000													5	15					0	0	0.001984	0	0
ACSM5	54988	broad.mit.edu	37	16	20448599	20448599	+	Silent	SNP	C	C	T	rs9652590	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:20448599C>T	ENST00000331849.4	+	12	1593	c.1446C>T	c.(1444-1446)atC>atT	p.I482I		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	482					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						GCTACCGGATCGGGCCTGTTG	0.552000													23	64					0	0	0.021523	0	0
REST	5978	broad.mit.edu	37	4	57796419	57796419	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:57796419C>T	ENST00000309042.7	+	4	1709	c.1395C>T	c.(1393-1395)tcC>tcT	p.S465S		NM_001193508.1|NM_005612.4	NP_001180437.1|NP_005603.3	Q13127	REST_HUMAN	RE1-silencing transcription factor	465	Lys-rich.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	50	Glioma(25;0.08)|all_neural(26;0.181)					ATGAAAAGTCCGTCAAAGCAG	0.373000													8	26					0	0	0.003080	0	0
AMPD1	270	broad.mit.edu	37	1	115229518	115229518	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:115229518G>A	ENST00000369538.3	-	3	363	c.316C>T	c.(316-318)Caa>Taa	p.Q106*	AMPD1_ENST00000520113.2_Nonsense_Mutation_p.Q110*|AMPD1_ENST00000353928.6_Nonsense_Mutation_p.Q77*	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	77					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TTCCGTCCTTGGAAACGCTTT	0.358000													13	46					0	0	0.003163	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77528660	77528660	+	Splice_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:77528660G>A	ENST00000477717.1	+	5	1015	c.779_splice	c.e5-1	p.R260_splice		NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	260					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						CCTCCTACAGGGATCCCAATC	0.368000													6	23					0	0	0.001984	0	0
CUTA	51596	broad.mit.edu	37	6	33385890	33385890	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:33385890A>G	ENST00000374500.5	-	1	204	c.73T>C	c.(73-75)Ttt>Ctt	p.F25L	CUTA_ENST00000492510.1_5'UTR|CUTA_ENST00000488034.1_5'UTR	NM_001014433.2	NP_001014433.1	O60888	CUTA_HUMAN	cutA divalent cation tolerance homolog (E. coli)	0					protein localization|response to metal ion	membrane	enzyme binding		SLC22A1/CUTA(2)	kidney(1)|lung(3)|urinary_tract(1)	5						TGATTAGAAAACAGCGCGCAC	0.572000													43	51					0	0	0.014410	0	0
PSG2	5670	broad.mit.edu	37	19	43575951	43575951	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:43575951G>A	ENST00000406487.1	-	4	963	c.865C>T	c.(865-867)Ccc>Tcc	p.P289S		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	289	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				GTAATTTGGGGGATAAACAGA	0.458000													31	122					0	0	0.009535	0	0
CAMKK2	10645	broad.mit.edu	37	12	121712110	121712110	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:121712110G>A	ENST00000324774.5	-	2	1048	c.220C>T	c.(220-222)Ctg>Ttg	p.L74L	CAMKK2_ENST00000402834.4_Silent_p.L74L|CAMKK2_ENST00000347034.2_Silent_p.L74L|CAMKK2_ENST00000538733.1_Silent_p.L74L|CAMKK2_ENST00000412367.2_Silent_p.L74L|CAMKK2_ENST00000337174.3_Silent_p.L74L|CAMKK2_ENST00000392473.2_Silent_p.L74L|CAMKK2_ENST00000404169.3_Silent_p.L74L|CAMKK2_ENST00000535524.1_5'UTR|CAMKK2_ENST00000446440.2_Silent_p.L74L|CAMKK2_ENST00000392474.2_Silent_p.L74L	NM_006549.3	NP_006540.3	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase kinase 2, beta	74					calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	17	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCGGCCTCCAGGGGCCGGTCC	0.677000													74	177					0	0	0.014410	0	0
SV2A	9900	broad.mit.edu	37	1	149878275	149878275	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:149878275C>T	ENST00000369146.3	-	11	2302	c.1812G>A	c.(1810-1812)ggG>ggA	p.G604G	SV2A_ENST00000369145.1_Silent_p.G604G	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	604					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CTGCCAGTGTCCCCAGGAAGC	0.547000													43	70					0	0	0.014410	0	0
MXRA5	25878	broad.mit.edu	37	X	3239114	3239114	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:3239114C>T	ENST00000217939.6	-	5	4766	c.4612G>A	c.(4612-4614)Gaa>Aaa	p.E1538K		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1538						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCTTCTGTTTCTGGATTCCCC	0.433000													30	20					0	0	0.009535	0	0
FAAH2	158584	broad.mit.edu	37	X	57337090	57337090	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:57337090G>A	ENST00000374900.4	+	3	460	c.340G>A	c.(340-342)Gaa>Aaa	p.E114K		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	114						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						GCAGGAAGATGAAGCCACCCT	0.408000										HNSCC(52;0.14)			3	4					0	0	0.004672	0	0
RSPH9	221421	broad.mit.edu	37	6	43638553	43638553	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:43638553G>A	ENST00000372163.4	+	5	751	c.698G>A	c.(697-699)gGc>gAc	p.G233D	RSPH9_ENST00000372165.4_Silent_p.G250G	NM_152732.4	NP_689945.2	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog (Chlamydomonas)	233					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						ATGGAGAGGGGCAATGCCCTG	0.637000									Kartagener syndrome				26	45					0	0	0.010818	0	0
WASH3P	374666	broad.mit.edu	37	15	102516448	102516448	+	RNA	SNP	C	C	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:102516448C>G	ENST00000557932.1	+	0	1396																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						CAGAGGAGGACGAGGACGACT	0.657000													4	71					0	0	0.009096	0	0
CDC5L	988	broad.mit.edu	37	6	44413591	44413591	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:44413591C>T	ENST00000371477.3	+	15	2590	c.2291C>T	c.(2290-2292)cCc>cTc	p.P764L		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	764	Interaction with PLRG1.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCTGCTATTCCCCGGAGGCTA	0.398000													7	32					0	0	0.001984	0	0
SLC47A1	55244	broad.mit.edu	37	17	19458545	19458545	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:19458545C>T	ENST00000270570.4	+	7	650	c.564C>T	c.(562-564)atC>atT	p.I188I	SLC47A1_ENST00000395585.1_Silent_p.I188I|SLC47A1_ENST00000542886.1_Intron|SLC47A1_ENST00000457293.1_Silent_p.I188I|SLC47A1_ENST00000436810.2_Silent_p.I165I|SLC47A1_ENST00000584348.1_3'UTR|SLC47A1_ENST00000575023.1_Intron|SLC47A1_ENST00000571335.1_Intron	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	188						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					TGCCCCAGATCGTAACTGGAG	0.507000													52	102					0	0	0.014410	0	0
GAS2L1	10634	broad.mit.edu	37	22	29704233	29704233	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:29704233G>A	ENST00000471961.1	+	1	1186	c.138G>A	c.(136-138)ccG>ccA	p.P46P	GAS2L1_ENST00000403764.1_Silent_p.P46P|GAS2L1_ENST00000406549.3_Silent_p.P46P|GAS2L1_ENST00000341313.6_Silent_p.P46P|GAS2L1_ENST00000360113.2_Silent_p.P46P|GAS2L1_ENST00000407647.2_Silent_p.P46P|GAS2L1_ENST00000407854.1_Silent_p.P46P			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	46	CH.				cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						TGGGTCTCCCGGGTGGTGGCG	0.672000													5	5					0	0	0.001168	0	0
ABCC8	6833	broad.mit.edu	37	11	17428582	17428582	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:17428582G>A	ENST00000302539.4	-	25	3143	c.3018C>T	c.(3016-3018)tcC>tcT	p.S1006S	ABCC8_ENST00000389817.3_Silent_p.S1005S	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1005					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGCCGGCGGAGGACAGGTACT	0.617000													70	197					0	0	0.014410	0	0
BPIFB4	149954	broad.mit.edu	37	20	31671373	31671373	+	Missense_Mutation	SNP	C	C	T	rs140887073		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:31671373C>T	ENST00000375483.3	+	3	370	c.370C>T	c.(370-372)Cgc>Tgc	p.R124C		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	124						cytoplasm|extracellular region	lipid binding										CAGTGGCTATCGCAGTGCCGA	0.592000													23	63					0	0	0.018920	0	0
EZH2	2146	broad.mit.edu	37	7	148508726	148508726	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:148508726G>A	ENST00000320356.2	-	16	2059	c.1938C>T	c.(1936-1938)taC>taT	p.Y646Y	EZH2_ENST00000541220.1_Silent_p.Y590Y|EZH2_ENST00000350995.2_Silent_p.Y602Y|EZH2_ENST00000483967.1_Silent_p.Y632Y|EZH2_ENST00000460911.1_Silent_p.Y641Y|EZH2_ENST00000478654.1_Silent_p.Y590Y|EZH2_ENST00000476773.1_Silent_p.Y590Y	NM_001203247.1|NM_001203248.1|NM_004456.4	NP_001190176.1|NP_001190177.1|NP_004447.2	Q15910	EZH2_HUMAN	enhancer of zeste homolog 2 (Drosophila)	641	SET.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(313)|kidney(3)|large_intestine(8)|liver(1)|lung(23)|parathyroid(2)|skin(3)|upper_aerodigestive_tract(3)	359	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			CCTCTCCACAGTATTCTGAGA	0.378000			Mis		DLBCL								8	32					0	0	0.004482	0	0
SIRT7	51547	broad.mit.edu	37	17	79875933	79875933	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:79875933C>T	ENST00000328666.6	-	1	137	c.75G>A	c.(73-75)caG>caA	p.Q25Q		NM_016538.2	NP_057622.1	Q9NRC8	SIRT7_HUMAN	sirtuin 7	25	Arg-rich.				chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GGCGCTCCCTCTGCTGCTCCT	0.771000													14	23					0	0	0.020292	0	0
SYTL2	54843	broad.mit.edu	37	11	85435165	85435165	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:85435165C>T	ENST00000359152.5	-	1	3906	c.3907G>A	c.(3907-3909)Gag>Aag	p.E1303K	SYTL2_ENST00000525423.1_Missense_Mutation_p.E779K|SYTL2_ENST00000527523.1_Intron|SYTL2_ENST00000524452.1_Intron|SYTL2_ENST00000528231.1_Intron|SYTL2_ENST00000316356.4_Intron|SYTL2_ENST00000354566.3_Missense_Mutation_p.E779K|SYTL2_ENST00000389960.4_Intron	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	460					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TCCTCTTTCTCTTGTTTCATA	0.388000													21	47					0	0	0.010504	0	0
ABCD2	225	broad.mit.edu	37	12	40012795	40012795	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:40012795T>C	ENST00000308666.3	-	1	758	c.623A>G	c.(622-624)cAa>cGa	p.Q208R		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	208	ABC transmembrane type-1.|Interaction with PEX19.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						CGTAAGAGATTGGTCAGGGTT	0.403000													14	32					0	0	0.020292	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643088	1643088	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:1643088C>T	ENST00000399682.1	-	1	280	c.236G>A	c.(235-237)gGg>gAg	p.G79E		NM_001012709.1	NP_001012727.1	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	79	9 X 4 AA repeats of C-C-X-P.					keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCCATAGCCCCCCTTGGAGCC	0.667000													32	93					0	0	0.013726	0	0
MYO5B	4645	broad.mit.edu	37	18	47527636	47527636	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:47527636G>A	ENST00000285039.7	-	5	900	c.601C>T	c.(601-603)Ccc>Tcc	p.P201S		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	201	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TCCATGATGGGACTGGATGCC	0.592000													22	70					0	0	0.012319	0	0
IGSF1	3547	broad.mit.edu	37	X	130408775	130408775	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:130408775G>A	ENST00000370904.1	-	24	4432	c.3522C>T	c.(3520-3522)tgC>tgT	p.C1174C	IGSF1_ENST00000370903.3_Silent_p.C1188C|IGSF1_ENST00000361420.3_Silent_p.C1183C|IGSF1_ENST00000370910.1_Silent_p.C1174C			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	1183	Ig-like C2-type 12.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GGGGTCCTCGGCACTGAAGGG	0.507000													30	44					0	0	0.006320	0	0
PDE6A	5145	broad.mit.edu	37	5	149314188	149314188	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:149314188C>T	ENST00000255266.5	-	2	687	c.568G>A	c.(568-570)Gcc>Acc	p.A190T		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	190	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ATGATTATGGCCACCACATCC	0.448000													22	97					0	0	0.016522	0	0
C4orf51	646603	broad.mit.edu	37	4	146651099	146651099	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:146651099G>A	ENST00000438731.1	+	5	483	c.483G>A	c.(481-483)ggG>ggA	p.G161G		NM_001080531.1	NP_001074000.1	C9J302	CD051_HUMAN	chromosome 4 open reading frame 51	161										haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)	6						GTCGACGAGGGAAAGGTGTCC	0.483000													17	66					0	0	0.004990	0	0
TPTE2	93492	broad.mit.edu	37	13	20025334	20025334	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:20025334C>T	ENST00000400230.2	-	11	817	c.773G>A	c.(772-774)cGa>cAa	p.R258Q	TPTE2_ENST00000390680.2_Missense_Mutation_p.R181Q|TPTE2_ENST00000382977.4_Missense_Mutation_p.R258Q|TPTE2_ENST00000457266.2_Missense_Mutation_p.R147Q|TPTE2_ENST00000255310.6_Missense_Mutation_p.R181Q|TPTE2_ENST00000382975.4_Missense_Mutation_p.R218Q|TPTE2_ENST00000382978.1_Missense_Mutation_p.R218Q|TPTE2_ENST00000400103.2_Missense_Mutation_p.R147Q			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	258	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R181Q(2)		NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ATAGTGGTTTCGATGTTTCTT	0.363000													4	19					0	0	0.014758	0	0
FOXP1	27086	broad.mit.edu	37	3	71008430	71008430	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:71008430C>T	ENST00000318789.4	-	21	2527	c.2002G>A	c.(2002-2004)Gaa>Aaa	p.E668K	FOXP1_ENST00000475937.1_Missense_Mutation_p.E668K|FOXP1_ENST00000468577.1_Missense_Mutation_p.E604K|FOXP1_ENST00000498215.1_Missense_Mutation_p.E668K|FOXP1_ENST00000493089.1_Missense_Mutation_p.E667K|FOXP1_ENST00000484350.1_Missense_Mutation_p.E592K|FOXP1_ENST00000491238.1_Missense_Mutation_p.E670K	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	668					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		GGTTCATCTTCGTAATCTCTG	0.478000			T	PAX5	ALL								40	123					0	0	0.014410	0	0
DNAH5	1767	broad.mit.edu	37	5	13885137	13885137	+	Missense_Mutation	SNP	G	G	A	rs143673459		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:13885137G>A	ENST00000265104.4	-	19	3048	c.2944C>T	c.(2944-2946)Cgc>Tgc	p.R982C	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	982	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATACGTTTGCGAATGGCCTCT	0.438000									Kartagener syndrome				18	86					0	0	0.006122	0	0
ZNF831	128611	broad.mit.edu	37	20	57829603	57829603	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:57829603G>A	ENST00000371030.2	+	5	4839	c.4839G>A	c.(4837-4839)agG>agA	p.R1613R		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1613						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GTGACGGTAGGAAACGTCAGG	0.493000													23	48					0	0	0.004656	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88211343	88211343	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:88211343G>A	ENST00000357081.3	-	18	2501	c.2357C>T	c.(2356-2358)tCg>tTg	p.S786L	AGTPBP1_ENST00000376109.3_Missense_Mutation_p.S798L|AGTPBP1_ENST00000337006.4_3'UTR|AGTPBP1_ENST00000432218.1_Intron|AGTPBP1_ENST00000376083.3_Missense_Mutation_p.S746L			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	786					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						TTCCTGAACCGAATACATGAG	0.313000													6	26					0	0	0.004482	0	0
AADACL2	344752	broad.mit.edu	37	3	151458570	151458570	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:151458570G>A	ENST00000356517.3	+	2	384	c.275G>A	c.(274-276)cGa>cAa	p.R92Q		NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2	92						extracellular region|integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			ATTCCAGTACGATTGTACTTG	0.378000													9	17					0	0	0.004482	0	0
RGS8	85397	broad.mit.edu	37	1	182616032	182616032	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:182616032G>A	ENST00000483095.2	-	7	638	c.381C>T	c.(379-381)acC>acT	p.T127T	RGS8_ENST00000258302.4_Silent_p.T145T|RGS8_ENST00000367556.1_Silent_p.T127T|RGS8_ENST00000367557.4_Silent_p.T127T			P57771	RGS8_HUMAN	regulator of G-protein signaling 8	127	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	5						TGGCTTCTCGGGTCTGGAAGT	0.507000													34	129					0	0	0.019004	0	0
GPR98	84059	broad.mit.edu	37	5	90074268	90074268	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:90074268G>A	ENST00000405460.2	+	63	12787	c.12691G>A	c.(12691-12693)Gaa>Aaa	p.E4231K		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4231	Calx-beta 28.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CATTCCCGAGGAAAAAAGCTT	0.443000													7	10					0	0	0.001984	0	0
ANO2	57101	broad.mit.edu	37	12	5672572	5672572	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:5672572G>T	ENST00000356134.5	-	27	2964	c.2893C>A	c.(2893-2895)Cca>Aca	p.P965T	ANO2_ENST00000546188.1_Missense_Mutation_p.P965T|ANO2_ENST00000327087.8_Missense_Mutation_p.P964T	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	969						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CCACCTCCTGGGCTCCTCAGA	0.562000													4	6					2.56e-06	2.66209e-06	0.009096	1	0
RP11-24M17.5	0	broad.mit.edu	37	15	76071779	76071779	+	RNA	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:76071779A>T	ENST00000395215.3	+	0	291																											AAGCTCCGCAATAATCAATCA	0.502000													5	21					0	0	0.014758	0	0
GPR115	221393	broad.mit.edu	37	6	47682221	47682221	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:47682221C>T	ENST00000283303.2	+	6	1498	c.1240C>T	c.(1240-1242)Cta>Tta	p.L414L	GPR115_ENST00000327753.3_Silent_p.L414L|GPR115_ENST00000371220.1_Silent_p.L471L	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	414					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CGTCTCAATCCTAAGCTTGGT	0.488000													17	43					0	0	0.008871	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323993	79323993	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:79323993G>A	ENST00000428286.1	-	8	3320	c.2120C>T	c.(2119-2121)tCc>tTc	p.S707F	PRUNE2_ENST00000376718.3_Missense_Mutation_p.S1066F			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1066					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						ATCCTCCATGGAGATATTCTT	0.453000													22	64					0	0	0.014323	0	0
TDRD1	56165	broad.mit.edu	37	10	115961172	115961172	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:115961172C>T	ENST00000251864.2	+	5	686	c.533C>T	c.(532-534)tCg>tTg	p.S178L	TDRD1_ENST00000369282.1_Missense_Mutation_p.S178L|TDRD1_ENST00000422662.1_5'UTR|TDRD1_ENST00000369280.1_Missense_Mutation_p.S178L|TDRD1_ENST00000369281.2_Missense_Mutation_p.S178L	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	178					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TTTCTAGGATCGCTGAGGTGC	0.458000													9	37					0	0	0.010729	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994883	140994883	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:140994883C>T	ENST00000285879.4	+	4	1979	c.1693C>T	c.(1693-1695)Cct>Tct	p.P565S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	565							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCACTACTTTCCTCAGAGCCC	0.572000										HNSCC(15;0.026)			113	108					0	0	0.014410	0	0
SULF1	23213	broad.mit.edu	37	8	70536400	70536400	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:70536400G>A	ENST00000260128.4	+	15	2535	c.1818G>A	c.(1816-1818)gtG>gtA	p.V606V	SULF1_ENST00000402687.4_Silent_p.V606V|SULF1_ENST00000458141.2_Silent_p.V606V|SULF1_ENST00000419716.3_Silent_p.V606V|SULF1_ENST00000521946.1_3'UTR	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	606					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GCAACGCCGTGGGCCCACCTA	0.512000													15	38					0	0	0.004990	0	0
AKNA	80709	broad.mit.edu	37	9	117108288	117108288	+	Splice_Site	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:117108288A>G	ENST00000307564.4	-	18	3677	c.3514_splice	c.e18-1	p.S1172_splice	AKNA_ENST00000492875.1_5'UTR|AKNA_ENST00000374079.4_Splice_Site_p.S117_splice|AKNA_ENST00000223791.3_Splice_Site_p.S632_splice|AKNA_ENST00000374088.3_Splice_Site_p.S1172_splice|AKNA_ENST00000374075.5_Splice_Site_p.S1091_splice	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						CAGATTCTGAACCTGGGGTAG	0.572000													8	19					0	0	0.004482	0	0
SENP6	26054	broad.mit.edu	37	6	76412391	76412391	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:76412391C>T	ENST00000370014.3	+	19	2938	c.2319C>T	c.(2317-2319)ttC>ttT	p.F773F	SENP6_ENST00000447266.2_Silent_p.F773F|SENP6_ENST00000370010.2_Silent_p.F766F|SENP6_ENST00000541192.1_Intron	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6	773	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				TTGTTTGTTTCCCCGGTTTGG	0.318000													9	17					0	0	0.008291	0	0
SMOC1	64093	broad.mit.edu	37	14	70459163	70459163	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:70459163G>A	ENST00000381280.4	+	6	809	c.556G>A	c.(556-558)Gag>Aag	p.E186K	SMOC1_ENST00000361956.3_Missense_Mutation_p.E186K	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	186					cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ACCCACGATGGAGACCCAGCC	0.438000													8	35					0	0	0.016723	0	0
GUCY2F	2986	broad.mit.edu	37	X	108708565	108708565	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:108708565G>A	ENST00000218006.2	-	3	1129	c.838C>T	c.(838-840)Cct>Tct	p.P280S		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	280					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						GCATCATAAGGAACAAAGACG	0.473000													34	36					0	0	0.019004	0	0
DNAH5	1767	broad.mit.edu	37	5	13794115	13794115	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:13794115G>A	ENST00000265104.4	-	48	8044	c.7940C>T	c.(7939-7941)cCt>cTt	p.P2647L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2647	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTTTCCCGCAGGAGGGCCATA	0.368000									Kartagener syndrome				17	24					0	0	0.006122	0	0
C10orf71	118461	broad.mit.edu	37	10	50531128	50531128	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:50531128C>T	ENST00000374144.3	+	3	826	c.538C>T	c.(538-540)Cca>Tca	p.P180S	C10orf71_ENST00000323868.4_Missense_Mutation_p.P180S			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	180										endometrium(1)	1						CGCTCCTCTTCCAGAAAACAG	0.522000													13	34					0	0	0.013537	0	0
THSD7A	221981	broad.mit.edu	37	7	11446644	11446644	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:11446644G>A	ENST00000423059.3	-	21	4206	c.3955C>T	c.(3955-3957)Caa>Taa	p.Q1319*	AC004160.4_ENST00000425837.1_RNA|AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1319	TSP type-1 13.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCATCACCTTGAAAGGGCTGG	0.468000										HNSCC(18;0.044)			6	12					0	0	0.001168	0	0
PSG9	5678	broad.mit.edu	37	19	43763210	43763210	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:43763210C>T	ENST00000418820.2	-	3	606	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K	PSG9_ENST00000291752.5_Intron|PSG9_ENST00000443718.3_Missense_Mutation_p.E170K|PSG9_ENST00000270077.3_Missense_Mutation_p.E263K|PSG9_ENST00000244293.7_Intron|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000593948.1_Intron			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	170	Ig-like C2-type 1.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				CTCTTAGGTTCACAGGTGAAG	0.493000													91	215					0	0	0.014410	0	0
OTOA	146183	broad.mit.edu	37	16	21716602	21716602	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:21716602G>A	ENST00000388958.3	+	11	1094	c.1093G>A	c.(1093-1095)Ggc>Agc	p.G365S	OTOA_ENST00000286149.4_Missense_Mutation_p.G379S|OTOA_ENST00000569064.1_3'UTR|OTOA_ENST00000388956.4_Missense_Mutation_p.G286S|OTOA_ENST00000388957.3_Missense_Mutation_p.G41S	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	379					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		CTTCCAGGCTGGCGTCCAGAA	0.557000													28	59					0	0	0.010818	0	0
ROR2	4920	broad.mit.edu	37	9	94538090	94538090	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:94538090C>T	ENST00000375708.3	-	2	306	c.108G>A	c.(106-108)gaG>gaA	p.E36E	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	36					negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GATCCAGAACCTCCACTTCAC	0.483000											OREG0019308	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	27					0	0	0.001984	0	0
MAP3K14	9020	broad.mit.edu	37	17	43350993	43350993	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:43350993G>A	ENST00000344686.2	-	0	1658							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CCGCCCCGGGGAGGAAGAGGA	0.622000													7	9					0	0	0.003080	0	0
SRPK2	6733	broad.mit.edu	37	7	104782625	104782625	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:104782625T>A	ENST00000357311.3	-	10	1511	c.1340A>T	c.(1339-1341)gAg>gTg	p.E447V	SRPK2_ENST00000393651.3_Missense_Mutation_p.E458V|SRPK2_ENST00000489828.1_Missense_Mutation_p.E447V	NM_001278273.1|NM_182691.1	NP_001265202.1|NP_872633.1	P78362	SRPK2_HUMAN	SRSF protein kinase 2	447	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(11)|large_intestine(6)|lung(4)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	35						GAACTGTGACTCGGGAATTTT	0.443000													41	71					0	0	0.009718	0	0
DAZL	1618	broad.mit.edu	37	3	16635178	16635178	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:16635178C>T	ENST00000250863.8	-	9	1066	c.779G>A	c.(778-780)gGa>gAa	p.G260E	DAZL_ENST00000399444.2_Missense_Mutation_p.G240E	NM_001190811.1	NP_001177740.1	Q92904	DAZL_HUMAN	deleted in azoospermia-like	240					germ cell development|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding|translation activator activity		RAF1/DAZL(2)	endometrium(1)|large_intestine(3)|lung(4)|prostate(3)	11						TGGGCCATTTCCAGAGGGTGG	0.343000													8	9					0	0	0.006214	0	0
ANK1	286	broad.mit.edu	37	8	41615578	41615578	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:41615578C>T	ENST00000396942.1	-	2	188	c.105G>A	c.(103-105)ggG>ggA	p.G35G	ANK1_ENST00000379758.2_Silent_p.G35G|ANK1_ENST00000396945.1_Silent_p.G35G|ANK1_ENST00000265709.8_Silent_p.G68G|ANK1_ENST00000289734.7_Silent_p.G35G|ANK1_ENST00000347528.4_Silent_p.G35G|ANK1_ENST00000352337.4_Silent_p.G35G			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	35	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TAATATCTACCCCATTCCGCA	0.498000													88	389					0	0	0.014410	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145773559	145773559	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:145773559G>A	ENST00000276826.5	-	4	1112	c.911C>T	c.(910-912)cCg>cTg	p.P304L	ARHGAP39_ENST00000377307.2_Missense_Mutation_p.P304L|ARHGAP39_ENST00000540274.1_Missense_Mutation_p.P304L			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	304	Pro-rich.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						GCCATAGCGCGGGGAGGAGGG	0.687000													24	35					0	0	0.005443	0	0
FBXO42	54455	broad.mit.edu	37	1	16577615	16577615	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:16577615G>A	ENST00000375592.3	-	10	1920	c.1704C>T	c.(1702-1704)tcC>tcT	p.S568S		NM_018994.1	NP_061867.1	Q6P3S6	FBX42_HUMAN	F-box protein 42	568										autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	26		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		AGGGGCCTTTGGAGGACATCG	0.617000													24	41					0	0	0.016522	0	0
SH3TC1	54436	broad.mit.edu	37	4	8229510	8229510	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:8229510G>A	ENST00000539824.1	+	12	2235	c.1861G>A	c.(1861-1863)Gac>Aac	p.D621N	SH3TC1_ENST00000245105.3_Missense_Mutation_p.D697N			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	697							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						TTTGCACAGGGACTCGGGAGC	0.667000													13	34					0	0	0.003163	0	0
CRNKL1	51340	broad.mit.edu	37	20	20033086	20033086	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:20033086G>A	ENST00000377340.2	-	2	415	c.384C>T	c.(382-384)tcC>tcT	p.S128S	CRNKL1_ENST00000536226.1_5'UTR|CRNKL1_ENST00000377327.4_Silent_p.S116S	NM_001278628.1|NM_016652.4	NP_001265557.1|NP_057736.4	Q9BZJ0	CRNL1_HUMAN	crooked neck pre-mRNA splicing factor 1	128					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			breast(2)|cervix(2)|endometrium(7)|large_intestine(11)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(6)	45						AAAACAAACAGGATCTCGGAA	0.582000													22	51					0	0	0.021523	0	0
POLH	5429	broad.mit.edu	37	6	43582080	43582080	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:43582080C>T	ENST00000372236.4	+	11	2223	c.1928C>T	c.(1927-1929)cCg>cTg	p.P643L	POLH_ENST00000372226.1_3'UTR|POLH_ENST00000535400.1_Missense_Mutation_p.P581L	NM_006502.2	NP_006493.1	Q9Y253	POLH_HUMAN	polymerase (DNA directed), eta	643					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			TCCCTGGTACCGGTATGGGAT	0.502000								DNA polymerases (catalytic subunits)	Xeroderma Pigmentosum				43	202					0	0	0.010771	0	0
SACS	26278	broad.mit.edu	37	13	23907979	23907979	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:23907979G>A	ENST00000382298.3	-	10	10624	c.10036C>T	c.(10036-10038)Cct>Tct	p.P3346S	SACS_ENST00000382292.3_Missense_Mutation_p.P3346S|SACS_ENST00000402364.1_Missense_Mutation_p.P2596S	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3346					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GACAACAAAGGAACAAATGCA	0.383000													4	22					0	0	0.014758	0	0
PRPF3	9129	broad.mit.edu	37	1	150305459	150305459	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:150305459C>T	ENST00000324862.6	+	6	682	c.517C>T	c.(517-519)Cct>Tct	p.P173S	PRPF3_ENST00000543398.1_Missense_Mutation_p.P38S|PRPF3_ENST00000467329.1_3'UTR|PRPF3_ENST00000414970.2_Missense_Mutation_p.P124S	NM_004698.2	NP_004689.1	O43395	PRPF3_HUMAN	pre-mRNA processing factor 3	173					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		GCCAAAGACTCCTTCTTCCTC	0.443000													36	57					0	0	0.007835	0	0
GNAS	2778	broad.mit.edu	37	20	57415169	57415169	+	Missense_Mutation	SNP	G	G	A	rs139302910		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:57415169G>A	ENST00000313949.7	+	1	397	c.8G>A	c.(7-9)cGg>cAg	p.R3Q	GNAS-AS1_ENST00000443966.1_RNA|GNAS-AS1_ENST00000598163.1_RNA|GNAS_ENST00000371098.2_Missense_Mutation_p.R3Q|GNAS_ENST00000371075.3_Missense_Mutation_p.R3Q|GNAS-AS1_ENST00000424094.2_RNA			P63092	GNAS2_HUMAN	GNAS complex locus	0				C -> Y (in Ref. 8; AAH66923).	activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			AGGATGGATCGGAGGTCCCGG	0.657000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			18	63					0	0	0.008871	0	0
COL15A1	1306	broad.mit.edu	37	9	101806866	101806866	+	Missense_Mutation	SNP	C	C	T	rs140219439		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:101806866C>T	ENST00000375001.3	+	25	3014	c.2591C>T	c.(2590-2592)cCg>cTg	p.P864L		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	864	Triple-helical region 4 (COL4).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				AAGGGAGAGCCGGGTGCCATC	0.522000													13	58					0	0	0.004007	0	0
FAM135B	51059	broad.mit.edu	37	8	139165019	139165019	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:139165019C>T	ENST00000395297.1	-	13	1869	c.1699G>A	c.(1699-1701)Gaa>Aaa	p.E567K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	567										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACCAGGGGTTCAGCTCTGGAG	0.498000										HNSCC(54;0.14)			24	90					0	0	0.016522	0	0
C20orf194	25943	broad.mit.edu	37	20	3240173	3240173	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:3240173G>A	ENST00000252032.9	-	33	3075	c.3008C>T	c.(3007-3009)cCc>cTc	p.P1003L	C20orf194_ENST00000453730.2_3'UTR	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	1003										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						TCCGGAGAAGGGACTTGGCTT	0.537000													20	74					0	0	0.007413	0	0
RAB27A	5873	broad.mit.edu	37	15	55497898	55497898	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:55497898G>A	ENST00000396307.2	-	6	724	c.473C>T	c.(472-474)cCc>cTc	p.P158L	RAB27A_ENST00000336787.1_Missense_Mutation_p.P158L|RAB27A_ENST00000569493.1_Missense_Mutation_p.P158L|RAB27A_ENST00000564609.1_Missense_Mutation_p.P158L	NM_004580.4	NP_004571.2	P51159	RB27A_HUMAN	RAB27A, member RAS oncogene family	158					small GTPase mediated signal transduction	dendrite|exocytic vesicle|late endosome|lysosome|melanosome	GTP binding|GTPase activity	p.P158L(1)		endometrium(1)|large_intestine(2)|liver(1)|lung(3)|ovary(1)|skin(1)	9				all cancers(107;0.0273)|GBM - Glioblastoma multiforme(80;0.0993)		TTCAAAGTAGGGGATTCTGGA	0.428000													16	52					0	0	0.003163	0	0
PELI1	57162	broad.mit.edu	37	2	64323416	64323416	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:64323416C>T	ENST00000358912.4	-	6	975	c.533G>A	c.(532-534)gGa>gAa	p.G178E		NM_020651.3	NP_065702.2	Q96FA3	PELI1_HUMAN	pellino E3 ubiquitin protein ligase 1	178					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	19						ATCCATCTGTCCATCTGATGT	0.428000													9	45					0	0	0.008291	0	0
EIF4ENIF1	56478	broad.mit.edu	37	22	31850259	31850259	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:31850259G>A	ENST00000397525.1	-	10	1606	c.1383C>T	c.(1381-1383)caC>caT	p.H461H	EIF4ENIF1_ENST00000382180.2_Silent_p.H140H|RP11-247I13.11_ENST00000464523.1_RNA|EIF4ENIF1_ENST00000344710.5_Silent_p.H298H|EIF4ENIF1_ENST00000330125.5_Silent_p.H461H|EIF4ENIF1_ENST00000397523.1_Silent_p.H461H	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	461						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TCTCTTCTAGGTGTTCTGCCA	0.483000													18	61					0	0	0.008871	0	0
FAM71B	153745	broad.mit.edu	37	5	156589960	156589960	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:156589960G>A	ENST00000302938.4	-	2	1411	c.1316C>T	c.(1315-1317)cCc>cTc	p.P439L		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	439						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTTCCTACTGGGATGTCTGTC	0.517000													445	485					0	0	0.014410	0	0
DSP	1832	broad.mit.edu	37	6	7580938	7580938	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:7580938G>A	ENST00000379802.3	+	23	4856	c.4515G>A	c.(4513-4515)gcG>gcA	p.A1505A	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1505	Central fibrous rod domain.		A -> V.		cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ATGAAAACGCGAGATTACAAA	0.433000													34	52					0	0	0.017118	0	0
TTC17	55761	broad.mit.edu	37	11	43413392	43413392	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:43413392C>T	ENST00000039989.4	+	5	567	c.553C>T	c.(553-555)Ctt>Ttt	p.L185F	TTC17_ENST00000299240.6_Missense_Mutation_p.L185F|RP11-484D2.4_ENST00000394183.2_RNA	NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	185							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						GAGAGTTAATCTTTCTGCACC	0.353000													24	57					0	0	0.021523	0	0
ANKS1A	23294	broad.mit.edu	37	6	34937853	34937853	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:34937853C>T	ENST00000360359.3	+	3	483	c.345C>T	c.(343-345)taC>taT	p.Y115Y	ANKS1A_ENST00000535627.1_Silent_p.Y115Y	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	115						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						AAGGCTGCTACCCTCTGCATT	0.512000													28	41					0	0	0.007291	0	0
CDH18	1016	broad.mit.edu	37	5	19473355	19473355	+	Missense_Mutation	SNP	C	C	T	rs149640304		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:19473355C>T	ENST00000507958.1	-	15	3343	c.2353G>A	c.(2353-2355)Gaa>Aaa	p.E785K	CDH18_ENST00000510297.1_5'UTR|CDH18_ENST00000274170.4_Missense_Mutation_p.E785K|CDH18_ENST00000382275.1_Missense_Mutation_p.E785K			Q13634	CAD18_HUMAN	cadherin 18, type 2	785					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTTTCAGATTCTATTTCTCCA	0.438000													8	38					0	0	0.004482	0	0
FAM47A	158724	broad.mit.edu	37	X	34149812	34149812	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:34149812G>A	ENST00000346193.3	-	1	635	c.584C>T	c.(583-585)cCg>cTg	p.P195L		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	195	Pro-rich.							p.P195L(1)		NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						ATGGGACACCGGAGTCTCGGG	0.612000													23	21					0	0	0.016522	0	0
COMP	1311	broad.mit.edu	37	19	18895712	18895712	+	Silent	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:18895712T>C	ENST00000542601.2	-	15	2198	c.1809A>G	c.(1807-1809)caA>caG	p.Q603Q	COMP_ENST00000222271.2_Silent_p.Q636Q|COMP_ENST00000425807.1_Silent_p.Q583Q			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	636	Mediates cell survival and induction of the IAP family of survival proteins.|TSP C-terminal.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding			breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						GCACCTTGAGTTGGATGCCAG	0.617000													33	22					0	0	0.010818	0	0
UNC13B	10497	broad.mit.edu	37	9	35310610	35310610	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:35310610C>T	ENST00000378495.3	+	9	1130	c.908C>T	c.(907-909)tCc>tTc	p.S303F	UNC13B_ENST00000378496.4_Missense_Mutation_p.S303F|UNC13B_ENST00000396787.1_Missense_Mutation_p.S315F	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	303					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			CACAGCCTGTCCAGAGATGGC	0.507000													12	45					0	0	0.016723	0	0
ADORA3	140	broad.mit.edu	37	1	112043112	112043112	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:112043112G>A	ENST00000241356.4	-	2	822	c.417C>T	c.(415-417)ttC>ttT	p.F139F	ADORA3_ENST00000369716.4_Intron|ADORA3_ENST00000369717.4_Intron	NM_000677.3	NP_000668.1	P33765	AA3R_HUMAN	adenosine A3 receptor	139					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	ATCCCACCAGGAATGACACCA	0.498000													26	90					0	0	0.021523	0	0
COL5A1	1289	broad.mit.edu	37	9	137593132	137593132	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:137593132G>A	ENST00000371817.3	+	4	1021	c.607G>A	c.(607-609)Ggc>Agc	p.G203S	COL5A1_ENST00000464187.1_3'UTR	NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	203	Laminin G-like.|TSP N-terminal.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CGACATCAATGGCATCATCGT	0.552000													11	29					0	0	0.013537	0	0
CD300LB	124599	broad.mit.edu	37	17	72522111	72522111	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:72522111C>G	ENST00000392621.1	-	2	261	c.257G>C	c.(256-258)tGg>tCg	p.W86S	CD300LB_ENST00000314401.3_Missense_Mutation_p.W86S	NM_174892.2	NP_777552.2	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	49	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(1)	21						CCCTCGGCACCACCACTTAAT	0.547000													4	222					0	0	0.014758	0	0
FAM73B	84895	broad.mit.edu	37	9	131830145	131830145	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:131830145C>T	ENST00000358369.4	+	12	1490	c.1264C>T	c.(1264-1266)Cga>Tga	p.R422*	FAM73B_ENST00000277475.5_3'UTR|FAM73B_ENST00000406926.2_3'UTR	NM_032809.2	NP_116198.2	Q7L4E1	FA73B_HUMAN	family with sequence similarity 73, member B	422						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)	13						GCTGGAGGGCCGAGGGGTGAG	0.632000													6	11					0	0	0.003080	0	0
EYA1	2138	broad.mit.edu	37	8	72123484	72123484	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:72123484T>A	ENST00000340726.3	-	17	2244	c.1605A>T	c.(1603-1605)gaA>gaT	p.E535D	EYA1_ENST00000388743.2_Missense_Mutation_p.E534D|EYA1_ENST00000388741.2_Missense_Mutation_p.E501D|EYA1_ENST00000388740.3_Missense_Mutation_p.E502D|EYA1_ENST00000419131.1_Missense_Mutation_p.E500D|EYA1_ENST00000303824.7_Missense_Mutation_p.E529D|EYA1_ENST00000388742.4_Missense_Mutation_p.E535D	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	535					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CAAAACAGCTTTCTTTTCCTA	0.333000													9	26					0	0	0.006214	0	0
PICK1	9463	broad.mit.edu	37	22	38461067	38461067	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:38461067C>T	ENST00000404072.3	+	4	559	c.212C>T	c.(211-213)aCc>aTc	p.T71I	PICK1_ENST00000356976.3_Missense_Mutation_p.T71I|PICK1_ENST00000468288.1_3'UTR|RP5-1039K5.13_ENST00000445483.1_RNA	NM_001039583.1|NM_001039584.1	NP_001034672.1|NP_001034673.1	Q9NRD5	PICK1_HUMAN	protein interacting with PRKCA 1	71	PDZ.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	Melanoma(58;0.045)					GATGAGATCACCGGTGTCAAT	0.557000													21	63					0	0	0.010504	0	0
ATP7B	540	broad.mit.edu	37	13	52518245	52518245	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:52518245C>T	ENST00000242839.4	-	14	3399	c.3243_splice	c.e14+1	p.E1081_splice	ATP7B_ENST00000448424.2_Splice_Site_p.E1003_splice|ATP7B_ENST00000400370.3_Splice_Site_p.E651_splice|ATP7B_ENST00000418097.2_Splice_Site_p.E1016_splice|ATP7B_ENST00000344297.5_Splice_Site_p.E874_splice|ATP7B_ENST00000417240.2_Intron|ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000400366.3_Splice_Site_p.E970_splice	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1081					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GTCCACGTACCTCTTTACAGT	0.597000									Wilson disease				12	34					0	0	0.016723	0	0
TRRAP	8295	broad.mit.edu	37	7	98608812	98608812	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:98608812G>A	ENST00000359863.4	+	70	11243	c.11034G>A	c.(11032-11034)ctG>ctA	p.L3678L	TRRAP_ENST00000355540.3_Silent_p.L3649L|TRRAP_ENST00000446306.3_Silent_p.L3667L	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3678	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGCTGGCTCTGATAGGCTTCG	0.552000													31	113					0	0	0.010818	0	0
CYP2A13	1553	broad.mit.edu	37	19	41600950	41600950	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:41600950C>T	ENST00000330436.3	+	8	1248	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	416					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	CCCAGCACTTCCTGGATAAGA	0.567000													44	121					0	0	0.008740	0	0
PRKAA2	5563	broad.mit.edu	37	1	57169687	57169687	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:57169687C>T	ENST00000371244.4	+	7	898	c.832C>T	c.(832-834)Cct>Tct	p.P278S		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	278					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						TTACTTATTTCCTGAAGACCC	0.353000													31	107					0	0	0.009535	0	0
FABP9	646480	broad.mit.edu	37	8	82371483	82371483	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:82371483C>T	ENST00000379071.2	-	2	218	c.163G>A	c.(163-165)Gaa>Aaa	p.E55K	RP11-157I4.4_ENST00000524085.2_RNA	NM_001080526.1	NP_001073995.1	Q0Z7S8	FABP9_HUMAN	fatty acid binding protein 9, testis	55							lipid binding|transporter activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6			Epithelial(68;0.186)			AAAGAACTTTCTGTTCTTATG	0.428000													15	29					0	0	0.004007	0	0
S100A7A	338324	broad.mit.edu	37	1	153390687	153390687	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:153390687C>T	ENST00000368729.4	+	2	186	c.129C>T	c.(127-129)ttC>ttT	p.F43F	S100A7A_ENST00000368728.2_Silent_p.F43F|S100A7A_ENST00000329256.2_Silent_p.F43F	NM_176823.3	NP_789793.1	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7A	43	EF-hand 1.					cytoplasm	calcium ion binding			cervix(1)|endometrium(3)|kidney(1)|lung(3)|prostate(1)|skin(2)|stomach(1)	12	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCCCCAATTTCCTCAGTGCCT	0.493000													31	107					0	0	0.012213	0	0
TARS2	80222	broad.mit.edu	37	1	150463152	150463152	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:150463152C>T	ENST00000369064.3	+	4	497	c.463C>T	c.(463-465)Cca>Tca	p.P155S	TARS2_ENST00000369054.2_Missense_Mutation_p.P155S|TARS2_ENST00000438568.2_Intron|TARS2_ENST00000606933.1_Missense_Mutation_p.P155S	NM_025150.3	NP_079426.2	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	155					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CTGCAGAGGTCCAAGTACAGA	0.493000													77	100					0	0	0.014410	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993849	140993849	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:140993849G>A	ENST00000285879.4	+	4	945	c.659G>A	c.(658-660)aGa>aAa	p.R220K	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	220							protein binding	p.R220I(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCCCTGAGAGAACTCAGAGT	0.493000										HNSCC(15;0.026)			44	77					0	0	0.009718	0	0
IGHG1	3500	broad.mit.edu	37	14	106208519	106208519	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:106208519G>A	ENST00000390548.2	-	0	380																											TGGGTTTTGGGGGGAAGAGGA	0.612000													21	70					0	0	0.021523	0	0
ZNF577	84765	broad.mit.edu	37	19	52376885	52376885	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:52376885G>A	ENST00000301399.5	-	7	723	c.358C>T	c.(358-360)Cat>Tat	p.H120Y	ZNF577_ENST00000412216.1_Intron|ZNF577_ENST00000451628.2_Intron|ZNF577_ENST00000420592.1_Intron|ZNF577_ENST00000485702.1_Intron	NM_032679.2	NP_116068.2	Q9BSK1	ZN577_HUMAN	zinc finger protein 577	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CGCTTGATATGGAGGCATGAT	0.373000													17	36					0	0	0.006122	0	0
NDUFAF2	91942	broad.mit.edu	37	5	60448757	60448757	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:60448757G>A	ENST00000296597.5	+	4	612	c.485G>A	c.(484-486)cGa>cAa	p.R162Q	NDUFAF2_ENST00000511107.1_3'UTR|NDUFAF2_ENST00000512623.1_3'UTR	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2	162						membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				TGGATGCCACGAGATGGCAAG	0.408000													13	9					0	0	0.020292	0	0
TSTA3	7264	broad.mit.edu	37	8	144695729	144695729	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:144695729C>T	ENST00000425753.2	-	9	878	c.775G>A	c.(775-777)Gtg>Atg	p.V259M	TSTA3_ENST00000529064.1_Missense_Mutation_p.V259M	NM_003313.3	NP_003304.1	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	259					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|skin(1)	9	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	GCCTCCACCACCGCCTCGGCT	0.682000													7	24					0	0	0.003080	0	0
FBXW7	55294	broad.mit.edu	37	4	153247254	153247254	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:153247254A>C	ENST00000281708.4	-	10	2777	c.1548T>G	c.(1546-1548)agT>agG	p.S516R	FBXW7_ENST00000603841.1_Missense_Mutation_p.S516R|FBXW7_ENST00000603548.1_Missense_Mutation_p.S516R|FBXW7_ENST00000296555.5_Missense_Mutation_p.S398R|FBXW7_ENST00000263981.5_Missense_Mutation_p.S436R|FBXW7_ENST00000393956.3_Missense_Mutation_p.S340R	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	516					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CATATGCTCCACTAACAACCC	0.438000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								6	22					0	0	0.001168	0	0
NLRP9	338321	broad.mit.edu	37	19	56243946	56243946	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:56243946C>T	ENST00000332836.2	-	2	1278	c.1251G>A	c.(1249-1251)agG>agA	p.R417R		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	417	NACHT.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ATAACCCATTCCTCCGGAGAT	0.493000													30	94					0	0	0.006320	0	0
KLHL13	90293	broad.mit.edu	37	X	117043518	117043518	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:117043518G>A	ENST00000371876.1	-	4	3380	c.959C>T	c.(958-960)tCg>tTg	p.S320L	KLHL13_ENST00000262820.3_Missense_Mutation_p.S371L|KLHL13_ENST00000539496.1_Missense_Mutation_p.S374L|KLHL13_ENST00000541812.1_Missense_Mutation_p.S355L|KLHL13_ENST00000371882.1_Missense_Mutation_p.S320L|KLHL13_ENST00000469946.1_Missense_Mutation_p.S320L|KLHL13_ENST00000545703.1_Missense_Mutation_p.S329L|KLHL13_ENST00000371878.1_Missense_Mutation_p.S320L|KLHL13_ENST00000540167.1_Missense_Mutation_p.S355L			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	371					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex		p.S371L(1)		NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GGGGGCTAACGATTTCCACTC	0.488000													13	68					0	0	0.013537	0	0
CBL	867	broad.mit.edu	37	11	119149242	119149242	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:119149242C>A	ENST00000264033.4	+	9	1626	c.1250C>A	c.(1249-1251)cCt>cAt	p.P417H		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	417	Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.P417R(2)|p.G397_I429del(1)|p.P417L(1)|p.E366_K477del(1)		breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CAGGGCTGTCCTTTCTGCCGA	0.428000			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				22	54					7.16444e-05	7.40471e-05	0.021523	1	0
COL4A1	1282	broad.mit.edu	37	13	110855923	110855923	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:110855923G>A	ENST00000375820.4	-	18	1110	c.989C>T	c.(988-990)cCa>cTa	p.P330L	COL4A1_ENST00000543140.1_Missense_Mutation_p.P330L	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	330	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AATTCCAGGTGGGCCAGGAGG	0.498000													35	100					0	0	0.008740	0	0
DNAH17	8632	broad.mit.edu	37	17	76425362	76425362	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:76425362C>T	ENST00000389840.5	-	76	12351	c.12227G>A	c.(12226-12228)cGc>cAc	p.R4076H	DNAH17_ENST00000585328.1_Missense_Mutation_p.R4077H|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AAAAAGGTAGCGGAGATCGTC	0.592000													15	66					0	0	0.006122	0	0
CEP55	55165	broad.mit.edu	37	10	95276761	95276761	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:95276761T>C	ENST00000371485.3	+	6	1053	c.749T>C	c.(748-750)gTt>gCt	p.V250A		NM_001127182.1|NM_018131.4	NP_001120654.1|NP_060601.3	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	250					cell division|mitosis	centriole|cleavage furrow|midbody				kidney(1)|large_intestine(5)|lung(6)|stomach(1)	13		Colorectal(252;0.207)				GATCTTGAGGTTGAACGACAA	0.363000													11	31					0	0	0.008291	0	0
MUT	4594	broad.mit.edu	37	6	49403220	49403220	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:49403220G>A	ENST00000274813.3	-	12	2200	c.2073C>T	c.(2071-2073)tcC>tcT	p.S691S		NM_000255.3	NP_000246.2	P22033	MUTA_HUMAN	methylmalonyl CoA mutase	691	B12-binding.				fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	30	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCCGTCCAAGGGAGTTAAGTT	0.468000													18	26					0	0	0.012319	0	0
FER1L6	654463	broad.mit.edu	37	8	125131862	125131862	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:125131862C>T	ENST00000522917.1	+	41	5611	c.5405C>T	c.(5404-5406)tCc>tTc	p.S1802F	FER1L6_ENST00000399018.1_Missense_Mutation_p.S1802F|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1802						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCAGACACCTCCTTTTCGTGG	0.468000													10	65					0	0	0.010729	0	0
HNRNPA0	10949	broad.mit.edu	37	5	137088949	137088949	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:137088949C>T	ENST00000314940.4	-	1	1090	c.807G>A	c.(805-807)aaG>aaA	p.K269K		NM_006805.3	NP_006796.1	Q13151	ROA0_HUMAN	heterogeneous nuclear ribonucleoprotein A0	269	Gly-rich.				nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|RNA binding			large_intestine(1)|lung(2)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			cgccgccgcTCTTCATGGGCC	0.677000													14	23					0	0	0.004990	0	0
OR8D2	283160	broad.mit.edu	37	11	124189829	124189829	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:124189829C>T	ENST00000357438.2	-	1	355	c.265G>A	c.(265-267)Gag>Aag	p.E89K		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		ATAATGTTCTCCTCTGGAACA	0.393000													4	2					0	0	0.014758	0	0
QSER1	79832	broad.mit.edu	37	11	32956278	32956278	+	Silent	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:32956278T>C	ENST00000399302.2	+	4	3422	c.3087T>C	c.(3085-3087)ggT>ggC	p.G1029G	QSER1_ENST00000527788.1_Silent_p.G790G	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1029										breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					CCTTAGGGGGTGACGACAGTG	0.423000													6	9					0	0	0.001984	0	0
ZNF284	342909	broad.mit.edu	37	19	44590395	44590395	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:44590395G>A	ENST00000421176.3	+	5	980	c.764G>A	c.(763-765)gGa>gAa	p.G255E	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				TTACACACAGGAGAAAAACCT	0.428000													15	56					0	0	0.020292	0	0
LMO7	4008	broad.mit.edu	37	13	76382275	76382275	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:76382275G>A	ENST00000357063.3	+	11	3272	c.2012G>A	c.(2011-2013)aGa>aAa	p.R671K	LMO7_ENST00000526202.1_Intron|LMO7_ENST00000341547.4_Intron|LMO7_ENST00000377534.3_Missense_Mutation_p.R671K|LMO7_ENST00000465261.2_Missense_Mutation_p.R386K|LMO7_ENST00000321797.8_Missense_Mutation_p.R386K			Q8WWI1	LMO7_HUMAN	LIM domain 7	671						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GACTTGAAGAGATGGGAGGCC	0.527000													12	11					0	0	0.020292	0	0
LPAR1	1902	broad.mit.edu	37	9	113704152	113704152	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:113704152C>T	ENST00000374431.3	-	4	725	c.342G>A	c.(340-342)cgG>cgA	p.R114R	LPAR1_ENST00000538760.1_Silent_p.R115R|LPAR1_ENST00000374430.2_Silent_p.R114R|LPAR1_ENST00000541779.1_Silent_p.R115R|LPAR1_ENST00000358883.4_Silent_p.R114R	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	114					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						CAGTCAGTCTCCGAGTATTGG	0.488000													22	83					0	0	0.004656	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79069870	79069870	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:79069870C>T	ENST00000388820.4	-	9	1593	c.1383G>A	c.(1381-1383)tcG>tcA	p.S461S	ADAMTS7_ENST00000566303.1_Intron	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	461					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CAGGTGGCACCGAGGGGAAGT	0.642000													3	11					0	0	0.004672	0	0
ZNF438	220929	broad.mit.edu	37	10	31137870	31137870	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:31137870G>A	ENST00000538351.1	-	7	2071	c.1317C>T	c.(1315-1317)tcC>tcT	p.S439S	ZNF438_ENST00000452305.1_Silent_p.S478S|ZNF438_ENST00000444692.2_Silent_p.S478S|ZNF438_ENST00000413025.1_Silent_p.S488S|ZNF438_ENST00000361310.3_Silent_p.S488S|ZNF438_ENST00000442986.1_Silent_p.S488S|ZNF438_ENST00000331737.6_Silent_p.S478S|ZNF438_ENST00000375311.1_Silent_p.S52S|ZNF438_ENST00000436087.2_Silent_p.S488S	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				TGGGCTTAGGGGAAGAGCTGT	0.478000													44	100					0	0	0.009718	0	0
FCRL1	115350	broad.mit.edu	37	1	157771723	157771723	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:157771723C>T	ENST00000358292.3	-	5	919	c.868G>A	c.(868-870)Gtg>Atg	p.V290M	FCRL1_ENST00000368176.3_Missense_Mutation_p.V290M|FCRL1_ENST00000491942.1_Missense_Mutation_p.V290M|FCRL1_ENST00000489998.1_5'UTR	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	290	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTGAGTGTCACCGCCTCACTG	0.547000													35	46					0	0	0.021022	0	0
SERPINA3	12	broad.mit.edu	37	14	95081240	95081240	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:95081240G>A	ENST00000553947.1	+	5	1425	c.537G>A	c.(535-537)acG>acA	p.T179T	SERPINA3_ENST00000393080.4_Silent_p.T154T|SERPINA3_ENST00000467132.1_Silent_p.T154T|SERPINA3_ENST00000393078.3_Silent_p.T154T|SERPINA3_ENST00000556388.1_Intron			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	154					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		ACAGGTTCACGGAGGATGCCA	0.527000													10	30					0	0	0.006214	0	0
CHD1L	9557	broad.mit.edu	37	1	146724344	146724344	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:146724344A>T	ENST00000369258.4	+	2	214	c.194A>T	c.(193-195)aAt>aTt	p.N65I	CHD1L_ENST00000361293.5_Intron|CHD1L_ENST00000431239.1_Missense_Mutation_p.N65I|CHD1L_ENST00000369259.3_Intron|CHD1L_ENST00000467213.1_3'UTR	NM_001256336.1|NM_004284.4|NM_024568.2	NP_001243265.1|NP_004275.4|NP_078844.2	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein 1-like	65	Helicase ATP-binding.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(923;0.0487)					CATTGTCAGAATGGCTGTATC	0.512000													41	53					0	0	0.007835	0	0
GPR45	11250	broad.mit.edu	37	2	105859055	105859055	+	Missense_Mutation	SNP	G	G	A	rs143245552	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:105859055G>A	ENST00000258456.1	+	1	856	c.740G>A	c.(739-741)cGg>cAg	p.R247Q		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	247						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						GCGGGCCTGCGGCGCCTGCAG	0.642000													42	84					0	0	0.011902	0	0
OSBPL6	114880	broad.mit.edu	37	2	179238741	179238741	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:179238741C>T	ENST00000190611.4	+	15	1896	c.1520C>T	c.(1519-1521)tCg>tTg	p.S507L	OSBPL6_ENST00000409631.1_Missense_Mutation_p.S471L|OSBPL6_ENST00000409045.3_Missense_Mutation_p.S476L|OSBPL6_ENST00000392505.2_Missense_Mutation_p.S532L|OSBPL6_ENST00000359685.3_Missense_Mutation_p.S471L|OSBPL6_ENST00000357080.4_Missense_Mutation_p.S440L|OSBPL6_ENST00000315022.2_Missense_Mutation_p.S511L	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	507					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			TCTGCAAGTTCGTCAGAGAAT	0.458000													23	77					0	0	0.004656	0	0
KALRN	8997	broad.mit.edu	37	3	124390539	124390539	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:124390539G>A	ENST00000360013.3	+	48	6860	c.6733G>A	c.(6733-6735)Gaa>Aaa	p.E2245K	KALRN_ENST00000428018.2_Missense_Mutation_p.E516K|KALRN_ENST00000459915.1_Missense_Mutation_p.E337K|KALRN_ENST00000291478.4_Missense_Mutation_p.E548K|KALRN_ENST00000393496.1_Missense_Mutation_p.E586K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2244					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TCAACGGAAAGAAAGGAGCAC	0.552000													27	74					0	0	0.012213	0	0
HCN1	348980	broad.mit.edu	37	5	45645701	45645701	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:45645701C>T	ENST00000303230.4	-	2	492	c.435G>A	c.(433-435)tgG>tgA	p.W145*		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	145						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity	p.W145*(1)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TTATTAAATCCCAGTAAAACC	0.308000													6	9					0	0	0.001984	0	0
COL3A1	1281	broad.mit.edu	37	2	189854859	189854859	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:189854859G>A	ENST00000304636.3	+	9	898	c.728G>A	c.(727-729)gGa>gAa	p.G243E	COL3A1_ENST00000317840.5_Missense_Mutation_p.G243E	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	243	Triple-helical region.		G -> V (in EDS4).		axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.G243E(1)		NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGAGAGCGAGGATTGCCTGGA	0.368000													6	6					0	0	0.001984	0	0
FYTTD1	84248	broad.mit.edu	37	3	197505288	197505288	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:197505288C>T	ENST00000428395.2	+	9	971	c.538C>T	c.(538-540)Cct>Tct	p.P180S	FYTTD1_ENST00000241502.3_Missense_Mutation_p.P271S|FYTTD1_ENST00000415708.2_Missense_Mutation_p.P245S|FYTTD1_ENST00000424384.2_Missense_Mutation_p.P204S|FYTTD1_ENST00000492360.1_3'UTR	NM_001011537.2	NP_001011537.2	Q96QD9	UIF_HUMAN	forty-two-three domain containing 1	271					mRNA export from nucleus	nuclear speck	mRNA binding|protein binding			kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	13	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.175)		CAAGAAAGTTCCTAAAGGTGT	0.348000													8	30					0	0	0.004482	0	0
FAM134C	162427	broad.mit.edu	37	17	40734258	40734258	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:40734258G>A	ENST00000309428.5	-	9	1033	c.974C>T	c.(973-975)tCc>tTc	p.S325F	FAM134C_ENST00000585894.1_Missense_Mutation_p.S228F|FAM134C_ENST00000543197.1_Missense_Mutation_p.S130F	NM_178126.3	NP_835227.1	Q86VR2	F134C_HUMAN	family with sequence similarity 134, member C	325						integral to membrane				endometrium(1)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	11		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		TCTGGCAAAGGATTCCTCTGG	0.537000													14	90					0	0	0.003163	0	0
CPM	1368	broad.mit.edu	37	12	69260720	69260720	+	Missense_Mutation	SNP	T	T	G	rs140807579	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:69260720T>G	ENST00000551568.1	-	7	956	c.896A>C	c.(895-897)aAt>aCt	p.N299T	CPM_ENST00000546373.1_Missense_Mutation_p.N299T|CPM_ENST00000338356.3_Missense_Mutation_p.N299T	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	299					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			GGCTTTGTTATTATTCCAAAA	0.358000													19	27					0	0	0.008871	0	0
RBP3	5949	broad.mit.edu	37	10	48389030	48389030	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:48389030G>A	ENST00000224600.4	-	1	1961	c.1848C>T	c.(1846-1848)atC>atT	p.I616I		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	616	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CGGCCAGCACGATGGCATCGG	0.672000													13	43					0	0	0.020292	0	0
CBLB	868	broad.mit.edu	37	3	105378047	105378047	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:105378047G>A	ENST00000264122.4	-	19	3037	c.2716C>T	c.(2716-2718)Cct>Tct	p.P906S	CBLB_ENST00000407712.1_Missense_Mutation_p.P121S|CBLB_ENST00000394027.3_Missense_Mutation_p.P884S	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	906	Interaction with SH3KBP1.|Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						CGTGGTTTAGGGGGTCTGGCT	0.433000			Mis S		AML								5	25					0	0	0.001168	0	0
EPAS1	2034	broad.mit.edu	37	2	46588101	46588101	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:46588101C>T	ENST00000263734.3	+	6	1161	c.651C>T	c.(649-651)ccC>ccT	p.P217P		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	217					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			ACAAGGAGCCCCTGCTGTCCT	0.567000													24	33					0	0	0.018920	0	0
TNN	63923	broad.mit.edu	37	1	175052945	175052945	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:175052945G>A	ENST00000239462.4	+	5	1221	c.1108G>A	c.(1108-1110)Gag>Aag	p.E370K		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	370	Fibronectin type-III 2.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCTTGACGTGGAGTGGGAAAA	0.562000													37	38					0	0	0.021022	0	0
OR10H4	126541	broad.mit.edu	37	19	16059926	16059926	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:16059926C>T	ENST00000322107.1	+	1	109	c.109C>T	c.(109-111)Ctg>Ttg	p.L37L		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						CCTGATGTTCCTGTTCACATT	0.498000													81	84					0	0	0.014410	0	0
KRT77	374454	broad.mit.edu	37	12	53088463	53088463	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:53088463C>T	ENST00000341809.3	-	5	1055	c.1027G>A	c.(1027-1029)Gaa>Aaa	p.E343K	RP11-641A6.3_ENST00000547533.1_RNA|KRT77_ENST00000537195.1_Missense_Mutation_p.E110K	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	343	Coil 2.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						GCAATCAGTTCATACTGGGTC	0.567000													12	29					0	0	0.010729	0	0
NOS1	4842	broad.mit.edu	37	12	117768489	117768489	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:117768489G>A	ENST00000317775.6	-	2	1071	c.386C>T	c.(385-387)cCc>cTc	p.P129L	NOS1_ENST00000338101.4_Missense_Mutation_p.P129L|NOS1_ENST00000344089.3_Missense_Mutation_p.P129L	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	129	Interaction with NOSIP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GGCTTTGGTGGGGGGACCCAG	0.652000													25	57					0	0	0.018920	0	0
CTPS1	1503	broad.mit.edu	37	1	41467908	41467908	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:41467908C>A	ENST00000372621.4	+	11	1679	c.1171C>A	c.(1171-1173)Cag>Aag	p.Q391K	CTPS1_ENST00000372616.1_Missense_Mutation_p.Q391K|CTPS1_ENST00000541520.1_Missense_Mutation_p.Q160K	NM_001905.2	NP_001896.2	P17812	PYRG1_HUMAN	CTP synthase 1	391	Glutamine amidotransferase type-1.				CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding			endometrium(3)|lung(10)	13					L-Glutamine(DB00130)	GGCTCGGAATCAGAAAAAGCC	0.478000													28	86					6.07407e-21	6.42468e-21	0.007291	1	0
SNRNP200	23020	broad.mit.edu	37	2	96955567	96955567	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:96955567G>A	ENST00000323853.5	-	21	2987	c.2910C>T	c.(2908-2910)gtC>gtT	p.V970V	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	970						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						TGTCGTACTTGACCAGATTGT	0.512000													26	83					0	0	0.007291	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7671210	7671210	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:7671210G>A	ENST00000446248.2	+	3	557	c.456G>A	c.(454-456)tgG>tgA	p.W152*	CAMSAP3_ENST00000160298.4_Nonsense_Mutation_p.W152*	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	152					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CCTTCGAGTGGACAAAGACCC	0.627000													56	61					0	0	0.014410	0	0
HTRA1	5654	broad.mit.edu	37	10	124266380	124266380	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:124266380C>T	ENST00000368984.3	+	4	1079	c.951C>T	c.(949-951)atC>atT	p.I317I		NM_002775.4	NP_002766.1	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1	317	Serine protease.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(8)|lung(7)	17		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				TGGACTACATCCAGACCGACG	0.602000													16	33					0	0	0.007413	0	0
GP9	2815	broad.mit.edu	37	3	128780637	128780637	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:128780637G>A	ENST00000307395.4	+	3	277	c.55G>A	c.(55-57)Gac>Aac	p.D19N		NM_000174.3	NP_000165.1	P14770	GPIX_HUMAN	glycoprotein IX (platelet)	19	LRRNT.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	GGCCACCAAGGACTGCCCCAG	0.711000													6	22					0	0	0.001984	0	0
GRIN2C	2905	broad.mit.edu	37	17	72846775	72846775	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:72846775G>A	ENST00000293190.5	-	5	1391	c.1245C>T	c.(1243-1245)atC>atT	p.I415I	GRIN2C_ENST00000347612.4_Silent_p.I415I	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	415					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GGCTCTCCACGATGACAAAGG	0.652000													13	88					0	0	0.016723	0	0
HCN1	348980	broad.mit.edu	37	5	45267329	45267329	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:45267329G>A	ENST00000303230.4	-	7	1702	c.1645C>T	c.(1645-1647)Cgt>Tgt	p.R549C		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	549						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CTGGCAGTACGACGTCCTTTG	0.408000													16	54					0	0	0.006122	0	0
OR2A14	135941	broad.mit.edu	37	7	143827001	143827001	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:143827001C>T	ENST00000408899.2	+	1	851	c.796C>T	c.(796-798)Cct>Tct	p.P266S		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					GTCCCGCCATCCTGAGGAGCA	0.547000													37	157					0	0	0.010771	0	0
IPO11	51194	broad.mit.edu	37	5	61833062	61833062	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:61833062C>T	ENST00000325324.6	+	24	2365	c.2196C>T	c.(2194-2196)tcC>tcT	p.S732S	KIF2A_ENST00000509663.2_3'UTR|IPO11_ENST00000409296.3_Silent_p.S772S	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	732						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		TATGCCAGTCCTTTTGTGAAC	0.284000													37	30					0	0	0.014410	0	0
C4orf17	84103	broad.mit.edu	37	4	100443719	100443719	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:100443719G>A	ENST00000514652.1	+	3	544	c.190G>A	c.(190-192)Gga>Aga	p.G64R	C4orf17_ENST00000503257.1_3'UTR|C4orf17_ENST00000326581.4_Missense_Mutation_p.G64R			Q53FE4	CD017_HUMAN	chromosome 4 open reading frame 17	64			G -> E (in dbSNP:rs13143848).							central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|urinary_tract(3)	18				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		AACATTGTGGGGAGTTGGCCA	0.428000													16	41					0	0	0.010504	0	0
SYN2	6854	broad.mit.edu	37	3	12224992	12224992	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:12224992G>A	ENST00000432424.2	+	0	1661							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						AAAAACAAACGAAAGGAAAGC	0.448000													20	62					0	0	0.007413	0	0
SEC63	11231	broad.mit.edu	37	6	108218933	108218933	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:108218933A>G	ENST00000369002.4	-	14	1539	c.1360T>C	c.(1360-1362)Tta>Cta	p.L454L		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	454	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TCATCATCTAACACTGTTAAG	0.333000													42	58					0	0	0.009718	0	0
C14orf166B	145497	broad.mit.edu	37	14	77297635	77297635	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:77297635C>T	ENST00000393774.3	+	3	431	c.307C>T	c.(307-309)Cgg>Tgg	p.R103W	C14orf166B_ENST00000460005.1_3'UTR|C14orf166B_ENST00000450042.2_Missense_Mutation_p.R86W	NM_194287.2	NP_919263.2	Q0VAA2	CN16B_HUMAN	chromosome 14 open reading frame 166B	103										breast(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(1)	18			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		CTACTTCATTCGGAACATGGA	0.537000													15	60					0	0	0.003163	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720218	140720218	+	Silent	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:140720218C>A	ENST00000394576.2	+	1	1680	c.1680C>A	c.(1678-1680)ccC>ccA	p.P560P	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACGCGCCCGAGATCCTGT	0.627000													50	271					2.74695e-27	2.91005e-27	0.014410	1	0
ZNF426	79088	broad.mit.edu	37	19	9639071	9639071	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:9639071A>T	ENST00000593003.1	-	6	2013	c.1536T>A	c.(1534-1536)caT>caA	p.H512Q	ZNF426_ENST00000253115.2_Missense_Mutation_p.H550Q|ZNF426_ENST00000535489.1_Missense_Mutation_p.H550Q			Q9BUY5	ZN426_HUMAN	zinc finger protein 426	550					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20						GAATTTGTTCATGTCTTCGAA	0.388000													30	25					0	0	0.013726	0	0
GBA3	57733	broad.mit.edu	37	4	22729088	22729088	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:22729088C>T	ENST00000503442.1	+	0	149				GBA3_ENST00000511446.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001128432.2	NP_001121904.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TTAGGCCTTTCTTTGTAAGTG	0.493000													20	53					0	0	0.010504	0	0
MIR520A	574467	broad.mit.edu	37	19	54194139	54194139	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:54194139G>A	ENST00000384862.1	+	0	5					NR_030189.1																						GAAGATCTCAGGCTGTGACCC	0.433000													48	124					0	0	0.014410	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140308247	140308247	+	Silent	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:140308247T>C	ENST00000253807.2	+	1	1770	c.1770T>C	c.(1768-1770)agT>agC	p.S590S	PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHAC1_ENST00000409700.3_Silent_p.S590S|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCTGACAGTGGTTCTAATG	0.517000													75	73					0	0	0.014410	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186760642	186760642	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:186760642C>T	ENST00000169298.3	+	4	825	c.151C>T	c.(151-153)Ctg>Ttg	p.L51L	ST6GAL1_ENST00000448044.1_Silent_p.L51L|ST6GAL1_ENST00000457772.2_Intron	NM_173216.2	NP_775323.1	P15907	SIAT1_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	51					humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		GTTAAAGAGTCTGGGGAAATT	0.507000													22	56					0	0	0.010504	0	0
MKI67	4288	broad.mit.edu	37	10	129903932	129903932	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:129903932C>T	ENST00000368654.3	-	13	6547	c.6172G>A	c.(6172-6174)Ggg>Agg	p.G2058R	MKI67_ENST00000368653.3_Missense_Mutation_p.G1698R	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2058	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding	p.G2058W(1)		NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTCTCCATCCCAGTTCCATAG	0.517000													73	188					0	0	0.014410	0	0
FEN1	2237	broad.mit.edu	37	11	61563517	61563517	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:61563517C>T	ENST00000305885.2	+	2	1097	c.684C>T	c.(682-684)atC>atT	p.I228I	FADS2_ENST00000574708.1_Intron	NM_004111.5	NP_004102.1	P39748	FEN1_HUMAN	flap structure-specific endonuclease 1	228	I-domain.				base-excision repair|DNA replication, removal of RNA primer|double-strand break repair|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|UV protection	mitochondrion|nucleolus|nucleoplasm	5'-3' exonuclease activity|5'-flap endonuclease activity|damaged DNA binding|double-stranded DNA binding|double-stranded DNA specific exodeoxyribonuclease activity|metal ion binding|protein binding|ribonuclease H activity			endometrium(1)|large_intestine(4)|lung(1)|ovary(1)	7						ATCTGTGCATCCTGCTAGGCA	0.567000								Editing and processing nucleases					20	43					0	0	0.010504	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75551178	75551178	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:75551178C>T	ENST00000604729.1	+	9	1537	c.1240C>T	c.(1240-1242)Cat>Tat	p.H414Y	ZSWIM8_ENST00000398706.2_Missense_Mutation_p.H414Y|ZSWIM8_ENST00000603114.1_Missense_Mutation_p.H414Y|ZSWIM8_ENST00000605216.1_Missense_Mutation_p.H414Y|ZSWIM8_ENST00000604524.1_Missense_Mutation_p.H414Y					zinc finger, SWIM-type containing 8																		GGTGGCAGCCCATGCCTGTGC	0.627000													18	34					0	0	0.004990	0	0
MYLK	4638	broad.mit.edu	37	3	123385168	123385168	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:123385168G>A	ENST00000360772.3	-	23	4107	c.3729C>T	c.(3727-3729)ttC>ttT	p.F1243F	MYLK_ENST00000360304.3_Silent_p.F1243F|MYLK_ENST00000346322.5_Silent_p.F1174F|MYLK_ENST00000354792.5_Silent_p.F43F|MYLK_ENST00000359169.1_Silent_p.F1243F|MYLK_ENST00000510775.1_5'UTR|MYLK_ENST00000475616.1_Silent_p.F1243F			Q15746	MYLK_HUMAN	myosin light chain kinase	1243	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 8.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GGTCCTCAGGGAACTGGATGA	0.557000													7	42					0	0	0.004482	0	0
OGFOD3	79701	broad.mit.edu	37	17	80361871	80361871	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:80361871A>G	ENST00000313056.5	-	7	792	c.641T>C	c.(640-642)aTa>aCa	p.I214T	OGFOD3_ENST00000329197.5_Missense_Mutation_p.I214T	NM_024648.2|NM_175902.4	NP_078924.1|NP_787098.3			2-oxoglutarate and iron-dependent oxygenase domain containing 3																		CGTGCTGTTTATGCGGGAGAA	0.637000													19	14					0	0	0.016522	0	0
DNAH7	56171	broad.mit.edu	37	2	196722274	196722274	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:196722274C>T	ENST00000312428.6	-	44	8341	c.8241G>A	c.(8239-8241)agG>agA	p.R2747R		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2747	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ACTGCAGAAACCTCATGTCAC	0.383000													6	21					0	0	0.001168	0	0
IKZF4	64375	broad.mit.edu	37	12	56428585	56428585	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:56428585C>T	ENST00000262032.5	+	12	1595	c.1228C>T	c.(1228-1230)Cct>Tct	p.P410S	RP11-603J24.4_ENST00000551846.1_RNA|IKZF4_ENST00000547791.1_Missense_Mutation_p.P365S|IKZF4_ENST00000547167.1_Missense_Mutation_p.P410S|IKZF4_ENST00000431367.2_Missense_Mutation_p.P308S			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	410					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			GCAGCCCCTCCCTGGTCGACT	0.637000													16	34					0	0	0.004007	0	0
SNTG2	54221	broad.mit.edu	37	2	1241662	1241662	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:1241662G>A	ENST00000308624.5	+	10	851	c.722G>A	c.(721-723)tGg>tAg	p.W241*	SNTG2_ENST00000407292.1_Nonsense_Mutation_p.W114*	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	241					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CTCCCCAGGTGGAATGCGTTC	0.672000													3	8					0	0	0.004672	0	0
C1orf168	199920	broad.mit.edu	37	1	57209936	57209936	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:57209936C>T	ENST00000343433.6	-	10	1471	c.1391G>A	c.(1390-1392)gGg>gAg	p.G464E	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	464										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						CTCCAGATGCCCACCTGAAAG	0.448000													3	9					0	0	0.004672	0	0
DSPP	1834	broad.mit.edu	37	4	88534234	88534234	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:88534234C>T	ENST00000399271.1	+	4	1016	c.896C>T	c.(895-897)tCa>tTa	p.S299L	RP11-742B18.1_ENST00000506480.1_RNA|DSPP_ENST00000282478.7_Missense_Mutation_p.S299L	NM_014208.3	NP_055023.2	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein	299					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		GGTCAAAATTCAGATAGTAAA	0.428000													12	26					0	0	0.010729	0	0
AADAC	13	broad.mit.edu	37	3	151545698	151545698	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:151545698G>A	ENST00000232892.6	+	5	1064	c.938G>A	c.(937-939)gGg>gAg	p.G313E	RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	313					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AAATATCCAGGGTTCCTAGAT	0.418000													6	30					0	0	0.001168	0	0
ARAP2	116984	broad.mit.edu	37	4	36212084	36212084	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:36212084G>A	ENST00000303965.4	-	6	1904	c.1415C>T	c.(1414-1416)cCc>cTc	p.P472L		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	472					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						GCAGGCATAGGGAGATATTGC	0.413000													7	20					0	0	0.001984	0	0
CCR1	1230	broad.mit.edu	37	3	46245004	46245004	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:46245004G>A	ENST00000296140.3	-	2	926	c.801C>T	c.(799-801)ttC>ttT	p.F267F	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	267					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GGGTGAACAGGAAGTCTTGGA	0.448000													7	24					0	0	0.004482	0	0
ZNF239	8187	broad.mit.edu	37	10	44052335	44052335	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:44052335G>A	ENST00000306006.6	-	2	1845	c.1193C>T	c.(1192-1194)aCt>aTt	p.T398I	ZNF239_ENST00000374446.2_Missense_Mutation_p.T398I|ZNF239_ENST00000535642.1_Missense_Mutation_p.T398I|ZNF239_ENST00000426961.1_Missense_Mutation_p.T398I	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						CTTCTCTCCAGTGTGGACTCT	0.522000													6	19					0	0	0.001984	0	0
PWP2	5822	broad.mit.edu	37	21	45535741	45535741	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:45535741G>A	ENST00000291576.7	+	7	903	c.776G>A	c.(775-777)gGa>gAa	p.G259E		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	259						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		ACCATCCGGGGAAAAGCCACT	0.632000													6	12					0	0	0.001168	0	0
POU5F1	5460	broad.mit.edu	37	6	31133727	31133727	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:31133727C>T	ENST00000259915.8	-	2	575	c.503G>A	c.(502-504)gGg>gAg	p.G168E	POU5F1_ENST00000471529.2_5'UTR|POU5F1_ENST00000441888.3_5'UTR|POU5F1_ENST00000606567.1_5'UTR|POU5F1_ENST00000512818.1_5'UTR|POU5F1_ENST00000513407.1_5'UTR	NM_002701.4	NP_002692.2	Q01860	PO5F1_HUMAN	POU class 5 homeobox 1	168	POU-specific.				anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	breast(1)|large_intestine(2)|lung(3)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	13						CAGGGTGAGCCCCACATCGGC	0.562000			T	EWSR1	sarcoma								17	16					0	0	0.006122	0	0
SUGP1	57794	broad.mit.edu	37	19	19416756	19416756	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:19416756G>A	ENST00000247001.5	-	4	787	c.440C>T	c.(439-441)tCc>tTc	p.S147F	SUGP1_ENST00000585763.1_5'UTR|SUGP1_ENST00000334782.5_Missense_Mutation_p.S147F	NM_172231.3	NP_757386.2	Q8IWZ8	SUGP1_HUMAN	SURP and G patch domain containing 1	147					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	22						CTTGGCGTGGGAGTAGCTCTT	0.672000													31	17					0	0	0.012213	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59899378	59899378	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:59899378G>A	ENST00000265036.5	-	9	1149	c.1082C>T	c.(1081-1083)tCc>tTc	p.S361F	DEPDC1B_ENST00000453022.2_Missense_Mutation_p.S361F|DEPDC1B_ENST00000545085.1_Missense_Mutation_p.S334F	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	361	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				GATGCAACGGGAAAATGTCTG	0.403000													10	32					0	0	0.013537	0	0
RTCA	8634	broad.mit.edu	37	1	100731969	100731969	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:100731969T>C	ENST00000370128.4	+	1	207	c.38T>C	c.(37-39)aTg>aCg	p.M13T	RTCA_ENST00000260563.4_Missense_Mutation_p.M13T|RTCA_ENST00000370126.1_Missense_Mutation_p.M13T|RTCA_ENST00000498617.1_3'UTR	NM_003729.3	NP_003720.1	O00442	RTC1_HUMAN	RNA 3'-terminal phosphate cyclase	13					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity										GGCAGCATCATGGAAGGGGTG	0.652000													25	54					0	0	0.009535	0	0
SPTBN5	51332	broad.mit.edu	37	15	42147787	42147787	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:42147787G>A	ENST00000320955.6	-	54	9405	c.9178C>T	c.(9178-9180)Cag>Tag	p.Q3060*		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3060					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCTGCTGTCTGCTGCAGCCGC	0.632000													11	17					0	0	0.010729	0	0
GML	2765	broad.mit.edu	37	8	143928000	143928000	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:143928000C>A	ENST00000220940.1	+	4	461	c.371C>A	c.(370-372)cCc>cAc	p.P124H		NM_002066.2	NP_002057.1	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule like	124	UPAR/Ly6.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane				NS(1)|central_nervous_system(2)|endometrium(1)|large_intestine(6)|lung(8)	18	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GACATGTTACCCGATGAAGTA	0.418000													14	74					1.3612e-06	1.41657e-06	0.003163	1	0
SERPINC1	462	broad.mit.edu	37	1	173883747	173883747	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:173883747C>T	ENST00000367698.3	-	2	470	c.352G>A	c.(352-354)Gct>Act	p.A118T	SERPINC1_ENST00000494024.1_5'UTR	NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	118					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	ATAGCAAAAGCCGTGGAGATA	0.507000											OREG0013990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	79					0	0	0.008361	0	0
NLRP8	126205	broad.mit.edu	37	19	56466958	56466958	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:56466958G>A	ENST00000291971.3	+	3	1605	c.1534G>A	c.(1534-1536)Gaa>Aaa	p.E512K	NLRP8_ENST00000590542.1_Missense_Mutation_p.E512K	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	512	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GACTTTTCAGGAATTTTTTGC	0.468000													44	132					0	0	0.014410	0	0
TMEM89	440955	broad.mit.edu	37	3	48659027	48659027	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:48659027G>A	ENST00000330862.3	-	1	261	c.163C>T	c.(163-165)Cct>Tct	p.P55S		NM_001008269.1	NP_001008270.1	A2RUT3	TMM89_HUMAN	transmembrane protein 89	55						integral to membrane				breast(1)|lung(1)|stomach(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CAGTAGCCAGGACAGCTCAGG	0.642000													10	37					0	0	0.010729	0	0
TNFAIP6	7130	broad.mit.edu	37	2	152226710	152226710	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:152226710G>A	ENST00000243347.3	+	4	646	c.571G>A	c.(571-573)Gat>Aat	p.D191N		NM_007115.3	NP_009046.2	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	191	CUB.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.131)		TTGCTTGGCTGATTATGTTGA	0.408000													20	84					0	0	0.018920	0	0
SLC22A10	387775	broad.mit.edu	37	11	63069867	63069867	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:63069867C>T	ENST00000544661.1	+	8	1100	c.672C>T	c.(670-672)ttC>ttT	p.F224F	SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000332793.6_Silent_p.F379F|SLC22A10_ENST00000526800.1_Intron|SLC22A10_ENST00000525620.1_Intron			Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	379						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GCAACATTTTCCTGTTGCAGG	0.408000													4	16					0	0	0.014758	0	0
NPAP1	23742	broad.mit.edu	37	15	24922344	24922344	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:24922344C>T	ENST00000329468.2	+	1	1804	c.1330C>T	c.(1330-1332)Ctt>Ttt	p.L444F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TATCCCTCCACTTTCCACCAC	0.527000													34	71					0	0	0.015359	0	0
DNAH5	1767	broad.mit.edu	37	5	13777445	13777445	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:13777445G>A	ENST00000265104.4	-	54	9075	c.8971C>T	c.(8971-8973)Ctg>Ttg	p.L2991L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2991	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCTTCCATCAGATTTGATGTG	0.333000									Kartagener syndrome				3	15					0	0	0.004672	0	0
MAGEE2	139599	broad.mit.edu	37	X	75003386	75003386	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:75003386C>T	ENST00000373359.2	-	1	1693	c.1501G>A	c.(1501-1503)Gag>Aag	p.E501K		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	501	MAGE 2.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCCACAGCCTCCCTATATTGT	0.488000													20	20					0	0	0.008871	0	0
ROBO1	6091	broad.mit.edu	37	3	78656102	78656102	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:78656102G>A	ENST00000436010.2	-	27	5405	c.4408C>T	c.(4408-4410)Cca>Tca	p.P1470S	ROBO1_ENST00000467549.1_Missense_Mutation_p.P1409S|ROBO1_ENST00000464233.1_Missense_Mutation_p.P1509S|ROBO1_ENST00000466906.1_5'UTR|ROBO1_ENST00000495273.1_Missense_Mutation_p.P1464S			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1509					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GGGAGTTTTGGCACCACTACA	0.473000													19	68					0	0	0.007413	0	0
P4HA1	5033	broad.mit.edu	37	10	74806745	74806745	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:74806745G>A	ENST00000412021.2	-	9	1348	c.1015C>T	c.(1015-1017)Cgc>Tgc	p.R339C	P4HA1_ENST00000440381.1_Missense_Mutation_p.R339C|P4HA1_ENST00000373008.2_Missense_Mutation_p.R339C|P4HA1_ENST00000263556.3_Missense_Mutation_p.R339C|P4HA1_ENST00000394890.2_Missense_Mutation_p.R339C|P4HA1_ENST00000307116.2_Missense_Mutation_p.R339C	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I	339						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCATGGAAGCGAATAATACGA	0.373000													21	49					0	0	0.016522	0	0
THSD7B	80731	broad.mit.edu	37	2	137988722	137988722	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:137988722C>T	ENST00000409968.1	+	8	2010	c.1832C>T	c.(1831-1833)tCa>tTa	p.S611L	THSD7B_ENST00000272643.3_Missense_Mutation_p.S611L|THSD7B_ENST00000413152.2_Missense_Mutation_p.S580L|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		ACGGAGTGGTCATCCTGTTCC	0.517000													13	20					0	0	0.020292	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610372	47610372	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:47610372G>A	ENST00000371891.3	+	8	1079	c.1048G>A	c.(1048-1050)Gag>Aag	p.E350K	CYP4A22_ENST00000294337.3_Missense_Mutation_p.E350K|CYP4A22_ENST00000485117.1_Intron|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000371890.3_Intron	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	350						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GTGCCGGGAGGAGATCCATGG	0.612000													20	46					0	0	0.014323	0	0
PPBP	5473	broad.mit.edu	37	4	74853765	74853765	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:74853765G>A	ENST00000296028.3	-	1	149	c.56C>T	c.(55-57)gCc>gTc	p.A19V		NM_002704.3	NP_002695.1	P02775	CXCL7_HUMAN	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	19					chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			breast(1)|central_nervous_system(1)|lung(1)|ovary(2)|skin(2)|stomach(1)|urinary_tract(2)	10	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			CACCTGCAAGGCATGAAGTGG	0.517000													14	38					0	0	0.004007	0	0
GEN1	348654	broad.mit.edu	37	2	17950004	17950004	+	Splice_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:17950004G>A	ENST00000381254.2	+	6	850		c.e6-1		SMC6_ENST00000402989.1_Intron|GEN1_ENST00000317402.7_Splice_Site	NM_001130009.1	NP_001123481.1	Q17RS7	GEN_HUMAN	GEN1 Holliday junction 5' flap endonuclease						DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(6)|central_nervous_system(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTTTCTGAAAGGGAGTCCCTG	0.343000								Homologous recombination					4	16					0	0	0.014758	0	0
ATP6V1H	51606	broad.mit.edu	37	8	54669124	54669124	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:54669124C>T	ENST00000355221.3	-	11	1773	c.1214G>A	c.(1213-1215)cGa>cAa	p.R405Q	ATP6V1H_ENST00000520188.1_Missense_Mutation_p.R383Q|ATP6V1H_ENST00000396774.2_Missense_Mutation_p.R423Q|ATP6V1H_ENST00000359530.2_Missense_Mutation_p.R423Q|ATP6V1H_ENST00000523899.1_Intron	NM_213619.2	NP_998784.1	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H	423					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism			endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|urinary_tract(1)	18		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			CCGTTTGCCTCGTGGATAATG	0.393000													11	19					0	0	0.010729	0	0
KCNT2	343450	broad.mit.edu	37	1	196300353	196300353	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:196300353C>T	ENST00000367433.5	-	18	2137	c.2036G>A	c.(2035-2037)gGa>gAa	p.G679E	KCNT2_ENST00000451324.2_Missense_Mutation_p.G290E|KCNT2_ENST00000294725.8_Missense_Mutation_p.G679E|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000367431.4_Missense_Mutation_p.G629E			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	679						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						GGGTGAACTTCCTATATATGG	0.323000													9	61					0	0	0.008291	0	0
KLRC2	3822	broad.mit.edu	37	12	10588420	10588420	+	Missense_Mutation	SNP	C	C	T	rs147031208		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:10588420C>T	ENST00000381902.2	-	1	172	c.166G>A	c.(166-168)Gat>Aat	p.D56N	KLRC2_ENST00000536833.2_Intron|KLRC2_ENST00000381901.1_Missense_Mutation_p.D56N|NKG2-E_ENST00000539033.1_Missense_Mutation_p.D56N	NM_002260.3	NP_002251.2	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C, member 2	56					cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity	p.D56H(1)		kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11						TATATTTTATCAATCCCTTGA	0.343000													23	35					0	0	0.004656	0	0
CNTN4	152330	broad.mit.edu	37	3	3095505	3095505	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:3095505G>A	ENST00000397461.1	+	23	3210	c.2826G>A	c.(2824-2826)tgG>tgA	p.W942*	CNTN4-AS1_ENST00000442749.2_RNA|CNTN4_ENST00000358480.3_Nonsense_Mutation_p.W723*|CNTN4_ENST00000427331.1_Nonsense_Mutation_p.W942*|CNTN4_ENST00000448906.2_Nonsense_Mutation_p.W614*|CNTN4_ENST00000397459.2_Nonsense_Mutation_p.W614*|CNTN4_ENST00000418658.1_Nonsense_Mutation_p.W942*	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	942	Fibronectin type-III 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TGTACAGATGGAACAGACAAA	0.403000													10	37					0	0	0.010729	0	0
IKZF4	64375	broad.mit.edu	37	12	56428444	56428444	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:56428444C>T	ENST00000262032.5	+	12	1454	c.1087C>T	c.(1087-1089)Cac>Tac	p.H363Y	RP11-603J24.4_ENST00000551846.1_RNA|IKZF4_ENST00000547791.1_Missense_Mutation_p.H318Y|IKZF4_ENST00000547167.1_Missense_Mutation_p.H363Y|IKZF4_ENST00000431367.2_Missense_Mutation_p.H261Y			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	363					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGTGGCACACCACAGCCTAGA	0.562000													39	100					0	0	0.006230	0	0
TPO	7173	broad.mit.edu	37	2	1480864	1480864	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:1480864G>A	ENST00000345913.4	+	8	917	c.826G>A	c.(826-828)Gag>Aag	p.E276K	TPO_ENST00000497517.2_Intron|TPO_ENST00000382201.3_Missense_Mutation_p.E276K|TPO_ENST00000349624.3_Intron|TPO_ENST00000382198.1_Intron|TPO_ENST00000346956.3_Missense_Mutation_p.E276K|TPO_ENST00000337415.3_Missense_Mutation_p.E276K|TPO_ENST00000329066.4_Missense_Mutation_p.E276K	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	276					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCAGCTCCCGGAGGAGGCCCG	0.706000													6	25					0	0	0.001984	0	0
UNC13B	10497	broad.mit.edu	37	9	35376085	35376085	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:35376085C>T	ENST00000378495.3	+	14	1651	c.1429C>T	c.(1429-1431)Cct>Tct	p.P477S	UNC13B_ENST00000378496.4_Missense_Mutation_p.P477S|UNC13B_ENST00000396787.1_Missense_Mutation_p.P489S	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	477					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GTGCACCACTCCTCATAACTT	0.517000													45	90					0	0	0.014410	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237491	140237491	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:140237491C>T	ENST00000307360.5	+	1	1858	c.1858C>T	c.(1858-1860)Ccg>Tcg	p.P620S	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCACGCATCCCGTTTCGCGT	0.632000													10	49					0	0	0.010729	0	0
WDR62	284403	broad.mit.edu	37	19	36558741	36558741	+	Silent	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:36558741A>T	ENST00000401500.2	+	7	746	c.711A>T	c.(709-711)acA>acT	p.T237T	WDR62_ENST00000270301.7_Silent_p.T237T|WDR62_ENST00000378860.4_3'UTR|WDR62_ENST00000388999.3_Silent_p.T237T	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	237					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TGACGAGCACAGTGCCCCTTG	0.592000													14	50					0	0	0.006122	0	0
CACNA1A	773	broad.mit.edu	37	19	13365963	13365963	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:13365963G>A	ENST00000360228.5	-	29	4700	c.4701C>T	c.(4699-4701)ttC>ttT	p.F1567F	CACNA1A_ENST00000573710.2_Silent_p.F1568F	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1568					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCGTGTACTCGAAAGGCGGAG	0.572000													26	24					0	0	0.008361	0	0
TAT	6898	broad.mit.edu	37	16	71606462	71606462	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:71606462C>T	ENST00000355962.4	-	5	671	c.538G>A	c.(538-540)Gga>Aga	p.G180R	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	180					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	ACCTCAATTCCCATAGACTCA	0.388000													13	44					0	0	0.004007	0	0
CSK	1445	broad.mit.edu	37	15	75094689	75094689	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:75094689C>T	ENST00000220003.9	+	13	1917	c.1188C>T	c.(1186-1188)gtC>gtT	p.V396V	CSK_ENST00000309470.9_Silent_p.V396V|CSK_ENST00000567571.1_Silent_p.V396V|CSK_ENST00000439220.2_Silent_p.V396V	NM_004383.2	NP_004374.1	P41240	CSK_HUMAN	c-src tyrosine kinase	396	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			central_nervous_system(1)|lung(2)	3						AGGACGTCGTCCCTCGGGTGG	0.652000													20	52					0	0	0.014323	0	0
CYP2B6	1555	broad.mit.edu	37	19	41522721	41522721	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:41522721C>T	ENST00000324071.4	+	9	1472	c.1465C>T	c.(1465-1467)Ctg>Ttg	p.L489L	CYP2B6_ENST00000593831.1_Silent_p.L253L|CYP2B6_ENST00000330446.5_Silent_p.L289L	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	489					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	GATCCGCTTCCTGCCCCGCTG	0.592000													10	21					0	0	0.010729	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58257932	58257932	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:58257932C>A	ENST00000249750.4	-	8	1659	c.892G>T	c.(892-894)Gat>Tat	p.D298Y	ALDH1A2_ENST00000537372.1_Missense_Mutation_p.D277Y|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.D260Y|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.D269Y|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.D202Y	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	298					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CAGTCAGCATCAGCAAAAATA	0.413000													8	33					5.18039e-06	5.37872e-06	0.003080	1	0
THRB	7068	broad.mit.edu	37	3	24169111	24169111	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:24169111C>T	ENST00000396671.2	-	10	1371	c.1023G>A	c.(1021-1023)ctG>ctA	p.L341L	THRB_ENST00000356447.4_Silent_p.L341L|THRB_ENST00000416420.1_Silent_p.L341L|THRB_ENST00000280696.5_Silent_p.L356L	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	341	Interaction with NR2F6.|Ligand-binding.		L -> P (in GTHR).		regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	CCCCATTTTTCAGCTGGCCCC	0.537000													12	73					0	0	0.003163	0	0
RIPK3	11035	broad.mit.edu	37	14	24808773	24808773	+	Silent	SNP	G	G	A	rs140844433		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:24808773G>A	ENST00000216274.5	-	2	269	c.51C>T	c.(49-51)tcC>tcT	p.S17S	RIPK3_ENST00000554338.1_5'UTR	NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	17					apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		GTTCCTCGATGGACACCAAGG	0.677000													32	79					0	0	0.019004	0	0
PAX4	5078	broad.mit.edu	37	7	127253582	127253582	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:127253582G>A	ENST00000341640.2	-	5	748	c.543C>T	c.(541-543)ttC>ttT	p.F181F	PAX4_ENST00000338516.3_Silent_p.F189F|PAX4_ENST00000378740.2_Silent_p.F181F|PAX4_ENST00000463946.1_Silent_p.F179F	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	189					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GCCCACGCTGGAACTCTGCGG	0.587000													25	46					0	0	0.018920	0	0
MOGS	7841	broad.mit.edu	37	2	74690339	74690339	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:74690339C>T	ENST00000233616.4	-	3	916	c.754G>A	c.(754-756)Gat>Aat	p.D252N	MOGS_ENST00000409065.1_Intron|MOGS_ENST00000462443.1_5'UTR|MOGS_ENST00000535045.1_3'UTR|MOGS_ENST00000452063.2_Missense_Mutation_p.D146N	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	252					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						GGGGCTGTATCCCCTGGACTG	0.537000													37	112					0	0	0.006230	0	0
KIAA2026	158358	broad.mit.edu	37	9	5922502	5922502	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:5922502G>T	ENST00000399933.3	-	8	3493	c.3494C>A	c.(3493-3495)cCa>cAa	p.P1165Q	KIAA2026_ENST00000381461.2_Missense_Mutation_p.P1135Q	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1165										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AGCTGTATTTGGTAGTTGGGT	0.353000													17	35					1.02788e-11	1.08215e-11	0.004990	1	0
UNC13A	23025	broad.mit.edu	37	19	17766795	17766795	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:17766795C>T	ENST00000428389.2	-	11	1443	c.1444G>A	c.(1444-1446)Gag>Aag	p.E482K	UNC13A_ENST00000550896.1_Missense_Mutation_p.E394K|UNC13A_ENST00000519716.2_Missense_Mutation_p.E394K|UNC13A_ENST00000551649.1_Missense_Mutation_p.E394K|UNC13A_ENST00000552293.1_Missense_Mutation_p.E394K|UNC13A_ENST00000252773.7_Missense_Mutation_p.E394K			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	394					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						TCGGGGGCCTCGGTGGGTGCC	0.662000													12	7					0	0	0.010729	0	0
SCNN1B	6338	broad.mit.edu	37	16	23382719	23382719	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:23382719C>T	ENST00000343070.2	+	6	1156	c.980C>T	c.(979-981)cCc>cTc	p.P327L	SCNN1B_ENST00000568923.1_Missense_Mutation_p.P300L|SCNN1B_ENST00000568085.1_Missense_Mutation_p.P327L|SCNN1B_ENST00000307331.5_Missense_Mutation_p.P372L	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	327					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	AGGTCATACCCCTTCATCAGA	0.602000													8	24					0	0	0.006214	0	0
FRMPD4	9758	broad.mit.edu	37	X	12712545	12712545	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:12712545C>T	ENST00000380682.1	+	9	1411	c.905C>T	c.(904-906)cCa>cTa	p.P302L		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	302	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						AGGAGAGATCCAGTTGCTTTC	0.403000													12	18					0	0	0.016723	0	0
C2orf16	84226	broad.mit.edu	37	2	27803944	27803944	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:27803944A>G	ENST00000408964.2	+	1	4556	c.4505A>G	c.(4504-4506)aAc>aGc	p.N1502S		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1502										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GAGTCTAAGAACTTGTCCACA	0.483000													25	62					0	0	0.005443	0	0
ABCA8	10351	broad.mit.edu	37	17	66873793	66873793	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:66873793C>T	ENST00000269080.2	-	31	4083	c.3946G>A	c.(3946-3948)Gat>Aat	p.D1316N	ABCA8_ENST00000430352.2_Missense_Mutation_p.D1356N|ABCA8_ENST00000586539.1_Missense_Mutation_p.D1356N	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1316	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					TCCAGGGCATCCCCTCCACCG	0.567000													61	80					0	0	0.014410	0	0
CXorf22	170063	broad.mit.edu	37	X	36007508	36007508	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:36007508G>A	ENST00000297866.5	+	16	2852	c.2786G>A	c.(2785-2787)gGa>gAa	p.G929E		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	929										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						CCAGAAGAAGGAGAATTTATT	0.383000													7	9					0	0	0.001984	0	0
PRSS3	5646	broad.mit.edu	37	9	33798555	33798555	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:33798555C>T	ENST00000361005.5	+	4	697	c.697C>T	c.(697-699)Cct>Tct	p.P233S	PRSS3_ENST00000429677.3_Missense_Mutation_p.P169S|PRSS3_ENST00000495682.1_3'UTR|PRSS3_ENST00000379405.3_Missense_Mutation_p.P176S|PRSS3_ENST00000342836.4_Missense_Mutation_p.P190S|RP11-133O22.6_ENST00000454429.2_RNA	NM_007343.3	NP_031369.2	P35030	TRY3_HUMAN	protease, serine, 3	233	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity			large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	13			LUSC - Lung squamous cell carcinoma(29;0.0176)			AGCCTCCTACCCTGGAAAGAT	0.542000													36	142					0	0	0.015359	0	0
OTUD4	54726	broad.mit.edu	37	4	146072028	146072028	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:146072028G>A	ENST00000454497.2	-	12	940	c.803C>T	c.(802-804)cCc>cTc	p.P268L	OTUD4_ENST00000447906.2_Missense_Mutation_p.P333L|OTUD4_ENST00000455611.2_5'UTR	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	332							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					GCTTTCTGGGGGAGGTGCCTT	0.403000													12	20					0	0	0.020292	0	0
EFCAB7	84455	broad.mit.edu	37	1	63997598	63997598	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:63997598G>C	ENST00000371088.4	+	3	541	c.295G>C	c.(295-297)Gaa>Caa	p.E99Q		NM_032437.2	NP_115813.2	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	99							calcium ion binding			breast(1)|endometrium(4)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	19						TTTAAGGAAGGAAAAACCTAC	0.313000													7	18					0	0	0.003080	0	0
C5orf42	65250	broad.mit.edu	37	5	37107844	37107844	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:37107844G>A	ENST00000274258.7	-	52	9735	c.6148C>T	c.(6148-6150)Cct>Tct	p.P2050S	C5orf42_ENST00000508244.1_Missense_Mutation_p.P3152S|C5orf42_ENST00000425232.2_Missense_Mutation_p.P3152S			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	3152										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ACCCCAAAAGGATGCTCTGGC	0.483000													8	11					0	0	0.006214	0	0
HNF1A	6927	broad.mit.edu	37	12	121416806	121416806	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:121416806G>A	ENST00000257555.6	+	1	461	c.235G>A	c.(235-237)Gaa>Aaa	p.E79K	HNF1A_ENST00000543427.1_Intron|HNF1A_ENST00000544413.1_Missense_Mutation_p.E79K|HNF1A_ENST00000402929.1_Missense_Mutation_p.E79K|HNF1A_ENST00000541395.1_Missense_Mutation_p.E79K|HNF1A-AS1_ENST00000537361.1_RNA|HNF1A_ENST00000400024.2_Missense_Mutation_p.E79K|HNF1A_ENST00000538626.1_Intron|HNF1A-AS1_ENST00000535301.1_RNA|HNF1A-AS1_ENST00000433033.2_RNA			P20823	HNF1A_HUMAN	HNF1 homeobox A	79	Asp/Glu-rich (acidic; potential involvement with transcription).				glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(8)|large_intestine(19)|liver(175)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	221	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CGACGATGGGGAAGACTTCAC	0.662000									Hepatic Adenoma, Familial Clustering of				71	195					0	0	0.014410	0	0
TRABD2A	129293	broad.mit.edu	37	2	85097750	85097750	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:85097750G>A	ENST00000335459.5	-	2	473	c.268C>T	c.(268-270)Ctc>Ttc	p.L90F	TRABD2A_ENST00000409520.2_Missense_Mutation_p.L90F|TRABD2A_ENST00000409133.1_Missense_Mutation_p.L90F	NM_001080824.1	NP_001074293.1			TraB domain containing 2A																		GGGTCTGTGAGATCCAACTCA	0.547000													10	13					0	0	0.006214	0	0
NUDCD3	23386	broad.mit.edu	37	7	44467277	44467277	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:44467277G>A	ENST00000355451.6	-	3	814	c.535C>T	c.(535-537)Ccc>Tcc	p.P179S	NUDCD3_ENST00000460110.1_5'UTR	NM_015332.3	NP_056147.2	Q8IVD9	NUDC3_HUMAN	NudC domain containing 3	179										endometrium(2)|large_intestine(1)|lung(3)|skin(1)	7						TAACTGTCGGGATTTTTCTGG	0.532000													10	37					0	0	0.008291	0	0
RBP3	5949	broad.mit.edu	37	10	48390152	48390152	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:48390152G>A	ENST00000224600.4	-	1	839	c.726C>T	c.(724-726)atC>atT	p.I242I		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	242	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GGATGTGCGCGATGTCCTCGG	0.647000													12	29					0	0	0.016723	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188600	140188600	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:140188600G>A	ENST00000530339.1	+	1	1828	c.1828G>A	c.(1828-1830)Gag>Aag	p.E610K	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.E610K|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.E610K|PCDHA2_ENST00000526136.1_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTTCGTACGAGCTGCAGCC	0.672000													65	64					0	0	0.014410	0	0
TMEM132D	121256	broad.mit.edu	37	12	130184903	130184903	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:130184903C>T	ENST00000422113.2	-	2	746	c.420G>A	c.(418-420)ctG>ctA	p.L140L		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	140						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TGGGCCGGCTCAGGTAGACTT	0.532000													9	32					0	0	0.006214	0	0
PITPNM1	9600	broad.mit.edu	37	11	67260440	67260440	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:67260440C>T	ENST00000356404.3	-	23	3661	c.3436G>A	c.(3436-3438)Ggc>Agc	p.G1146S	PITPNM1_ENST00000534749.1_Missense_Mutation_p.G1146S|PITPNM1_ENST00000436757.2_Missense_Mutation_p.G1145S	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	1146					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						ACGGCACGGCCCACGATGTAG	0.652000													41	95					0	0	0.008740	0	0
HNRNPF	3185	broad.mit.edu	37	10	43882742	43882742	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:43882742G>A	ENST00000443950.2	-	3	1077	c.591C>T	c.(589-591)ccC>ccT	p.P197P	HNRNPF_ENST00000356053.3_Silent_p.P197P|HNRNPF_ENST00000337970.3_Silent_p.P197P|HNRNPF_ENST00000357065.4_Silent_p.P197P|HNRNPF_ENST00000544000.1_Silent_p.P197P	NM_001098208.1	NP_001091678.1	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	197					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|urinary_tract(1)	19						ACTTCAGAGGGGGATCTGAGT	0.562000													26	73					0	0	0.004656	0	0
PDGFRB	5159	broad.mit.edu	37	5	149511573	149511573	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:149511573C>T	ENST00000261799.4	-	8	1681	c.1212G>A	c.(1210-1212)gaG>gaA	p.E404E		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	404					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGAGCTGGACCTCAGCATCCT	0.612000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								20	103					0	0	0.008871	0	0
NRP1	8829	broad.mit.edu	37	10	33481215	33481215	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:33481215G>A	ENST00000265371.4	-	14	2581	c.2056C>T	c.(2056-2058)Cac>Tac	p.H686Y	NRP1_ENST00000374867.2_Missense_Mutation_p.H686Y|NRP1_ENST00000395995.1_Missense_Mutation_p.H686Y			O14786	NRP1_HUMAN	neuropilin 1	686	MAM.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	ATACCTGTGTGATCCTGAATG	0.502000													45	140					0	0	0.011902	0	0
PCLO	27445	broad.mit.edu	37	7	82785576	82785576	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:82785576C>T	ENST00000423517.2	-	2	718	c.381G>A	c.(379-381)ggG>ggA	p.G127G	PCLO_ENST00000333891.8_Silent_p.G127G	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	127					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AAGGACTCCTCCCAGGCAATT	0.478000													19	62					0	0	0.014323	0	0
QSER1	79832	broad.mit.edu	37	11	32955554	32955554	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:32955554C>T	ENST00000399302.2	+	4	2698	c.2363C>T	c.(2362-2364)cCt>cTt	p.P788L	QSER1_ENST00000527788.1_Missense_Mutation_p.P549L	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	788	Gln-rich.									breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					CAACTCCATCCTCAAAATTCT	0.388000													9	22					0	0	0.006214	0	0
NMUR2	56923	broad.mit.edu	37	5	151784584	151784584	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:151784584C>T	ENST00000255262.3	-	1	256	c.91G>A	c.(91-93)Gag>Aag	p.E31K	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	31					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GCCAGATACTCCTCGGTGCTG	0.498000													40	115					0	0	0.006999	0	0
LPAR1	1902	broad.mit.edu	37	9	113704153	113704153	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:113704153C>T	ENST00000374431.3	-	4	724	c.341G>A	c.(340-342)cGg>cAg	p.R114Q	LPAR1_ENST00000538760.1_Missense_Mutation_p.R115Q|LPAR1_ENST00000374430.2_Missense_Mutation_p.R114Q|LPAR1_ENST00000541779.1_Missense_Mutation_p.R115Q|LPAR1_ENST00000358883.4_Missense_Mutation_p.R114Q	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	114					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						AGTCAGTCTCCGAGTATTGGG	0.493000													22	84					0	0	0.021523	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95111410	95111410	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:95111410C>T	ENST00000469935.1	+	0	1230					NR_015340.1																						CTGAACATTTCTAAAGTAAGT	0.502000													7	26					0	0	0.001984	0	0
COL1A1	1277	broad.mit.edu	37	17	48266550	48266550	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:48266550G>A	ENST00000225964.5	-	40	3034	c.2916C>T	c.(2914-2916)ttC>ttT	p.F972F		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	972	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GAAGACCAGGGAAGCCTCTCT	0.617000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						18	25					0	0	0.006122	0	0
SUSD4	55061	broad.mit.edu	37	1	223441998	223441998	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:223441998G>A	ENST00000343846.3	-	3	1014	c.381C>T	c.(379-381)atC>atT	p.I127I	SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000366878.4_Silent_p.I127I|SUSD4_ENST00000454695.2_5'UTR|SUSD4_ENST00000344029.6_Silent_p.I127I			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	127	Sushi 2.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		CAGCATCTTCGATTTGAGGGA	0.383000													26	86					0	0	0.008361	0	0
TFPI	7035	broad.mit.edu	37	2	188331670	188331670	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:188331670T>C	ENST00000233156.3	-	8	1202	c.908A>G	c.(907-909)aAt>aGt	p.N303S	AC007319.1_ENST00000412276.1_RNA|AC007319.1_ENST00000453517.1_RNA|TFPI_ENST00000392365.1_Missense_Mutation_p.N303S	NM_006287.4	NP_006278.1	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	303					blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	AATTCACATATTTTTAACAAA	0.239000													3	10					0	0	0.004672	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79069868	79069868	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:79069868A>C	ENST00000388820.4	-	9	1595	c.1385T>G	c.(1384-1386)gTg>gGg	p.V462G	ADAMTS7_ENST00000566303.1_Intron	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	462	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GCCAGGTGGCACCGAGGGGAA	0.642000													4	11					0	0	0.009096	0	0
SMPD3	55512	broad.mit.edu	37	16	68404909	68404909	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:68404909G>A	ENST00000219334.5	-	3	1779	c.1176C>T	c.(1174-1176)taC>taT	p.Y392Y	SMPD3_ENST00000563226.1_Silent_p.Y392Y|SMPD3_ENST00000566009.1_5'UTR|SMPD3_ENST00000568373.1_Silent_p.Y392Y	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	392					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	CCTGGCAGCCGTAGACCCCGA	0.577000													6	33					0	0	0.001984	0	0
TMEM108	66000	broad.mit.edu	37	3	133114707	133114707	+	Splice_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:133114707G>A	ENST00000321871.6	+	6	1815		c.e6-1		TMEM108_ENST00000508711.1_Splice_Site|TMEM108_ENST00000393130.3_Splice_Site	NM_001136469.1|NM_023943.2	NP_001129941.1|NP_076432.1	Q6UXF1	TM108_HUMAN	transmembrane protein 108							integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						TCTCTTCCCAGGACCAGCTCT	0.498000													19	59					0	0	0.007413	0	0
GPR97	222487	broad.mit.edu	37	16	57718364	57718364	+	Missense_Mutation	SNP	C	C	T	rs111888711	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:57718364C>T	ENST00000333493.4	+	10	1386	c.1225C>T	c.(1225-1227)Cgt>Tgt	p.R409C	GPR97_ENST00000327655.6_Missense_Mutation_p.R199C|RP11-405F3.4_ENST00000563062.1_RNA|GPR97_ENST00000450388.3_Missense_Mutation_p.R289C	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	409					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CTACACCATCCGTGATAGGGA	0.632000													11	37					0	0	0.010729	0	0
IL37	27178	broad.mit.edu	37	2	113676137	113676137	+	Splice_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:113676137G>A	ENST00000263326.3	+	5	450		c.e5-1		IL37_ENST00000349806.3_Splice_Site|IL37_ENST00000353225.3_Splice_Site|IL37_ENST00000311328.2_Splice_Site|IL37_ENST00000352179.3_Splice_Site	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37						immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						TTACCTCACAGAAGGAGAAAC	0.512000													16	48					0	0	0.003163	0	0
COQ4	51117	broad.mit.edu	37	9	131088142	131088142	+	Silent	SNP	C	C	T	rs111535641		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:131088142C>T	ENST00000300452.3	+	4	707	c.384C>T	c.(382-384)ctC>ctT	p.L128L	COQ4_ENST00000372875.3_Silent_p.L128L	NM_016035.3	NP_057119.2	Q9Y3A0	COQ4_HUMAN	coenzyme Q4	128					ubiquinone biosynthetic process	mitochondrial inner membrane				endometrium(4)|large_intestine(1)|lung(4)	9						GCGAGTATCTCCGTTTCCTGG	0.572000													9	33					0	0	0.006214	0	0
FCGBP	8857	broad.mit.edu	37	19	40419769	40419769	+	Silent	SNP	G	G	A	rs147457166	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:40419769G>A	ENST00000221347.6	-	6	3232	c.3225C>T	c.(3223-3225)ttC>ttT	p.F1075F		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1075	VWFD 2.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGCACTCCCGGAAGGGCCCCT	0.642000													26	90					0	0	0.008361	0	0
MKRN3	7681	broad.mit.edu	37	15	23811087	23811087	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:23811087G>A	ENST00000314520.3	+	1	634	c.158G>A	c.(157-159)aGg>aAg	p.R53K	MKRN3_ENST00000564592.1_Missense_Mutation_p.R53K|MKRN3_ENST00000568252.1_Missense_Mutation_p.R53K	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	53						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CATGCGGCAAGGGGCTGGGCC	0.692000													13	44					0	0	0.020292	0	0
CYP3A43	64816	broad.mit.edu	37	7	99447251	99447251	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:99447251C>T	ENST00000354829.2	+	7	707	c.604C>T	c.(604-606)Ccc>Tcc	p.P202S	CYP3A43_ENST00000222382.5_Missense_Mutation_p.P202S|CYP3A43_ENST00000417625.1_Intron|CYP3A43_ENST00000342499.4_Missense_Mutation_p.S64F|CYP3A43_ENST00000444905.1_Intron|CYP3A43_ENST00000477658.1_Intron|CYP3A43_ENST00000312017.5_Missense_Mutation_p.P202S|CYP3A43_ENST00000415413.1_Intron	NM_022820.3|NM_057095.1	NP_073731.1|NP_476436.1	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 43	202			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	TCCACAAGATCCCTTTCTGAA	0.348000													22	44					0	0	0.010504	0	0
KCNH6	81033	broad.mit.edu	37	17	61623198	61623198	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:61623198C>T	ENST00000583023.1	+	14	2931	c.2920C>T	c.(2920-2922)Ccc>Tcc	p.P974S	KCNH6_ENST00000314672.5_Missense_Mutation_p.P938S|KCNH6_ENST00000581784.1_Missense_Mutation_p.P885S|KCNH6_ENST00000456941.2_Missense_Mutation_p.P885S	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	974					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	TGGCTCTGTTCCCAAGCAGCT	0.562000													25	129					0	0	0.006320	0	0
TRHDE	29953	broad.mit.edu	37	12	73050711	73050711	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:73050711G>A	ENST00000261180.4	+	18	2950	c.2854G>A	c.(2854-2856)Gga>Aga	p.G952R		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	952					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTTGAGGTATGGAGAAGCATT	0.294000													9	25					0	0	0.016723	0	0
KIAA0922	23240	broad.mit.edu	37	4	154510071	154510071	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:154510071C>T	ENST00000409959.3	+	16	1631	c.1582C>T	c.(1582-1584)Ctg>Ttg	p.L528L	KIAA0922_ENST00000409663.3_Silent_p.L527L|KIAA0922_ENST00000440693.1_Silent_p.L528L	NM_001131007.1	NP_001124479.1	A2VDJ0	T131L_HUMAN	KIAA0922	527						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				GAGCCTTTCTCTGGATCAATC	0.343000													9	24					0	0	0.008291	0	0
CADPS2	93664	broad.mit.edu	37	7	121960381	121960381	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:121960381C>T	ENST00000334010.7	-	28	4144	c.3723G>A	c.(3721-3723)agG>agA	p.R1241R	CADPS2_ENST00000412584.2_Silent_p.R1202R|CADPS2_ENST00000313070.7_Silent_p.R1202R|CADPS2_ENST00000449022.2_Silent_p.R1243R	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	1243					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						ATCGAAAGTCCCTGTAGGTTT	0.388000													38	128					0	0	0.013114	0	0
GRM4	2914	broad.mit.edu	37	6	34008042	34008042	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:34008042C>T	ENST00000374181.3	-	7	1588	c.1419G>A	c.(1417-1419)ggG>ggA	p.G473G	GRM4_ENST00000455714.2_Silent_p.G333G|GRM4_ENST00000535756.1_Silent_p.G340G|GRM4_ENST00000538487.1_Silent_p.G473G|GRM4_ENST00000545715.1_Silent_p.G165G|GRM4_ENST00000374177.3_Silent_p.G357G|GRM4_ENST00000544773.1_Silent_p.G304G	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	473					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	TGTCATAGCGCCCAGGCGCAT	0.572000													48	134					0	0	0.014410	0	0
CEP104	9731	broad.mit.edu	37	1	3742987	3742987	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:3742987C>T	ENST00000378230.3	-	17	2526	c.2202G>A	c.(2200-2202)ggG>ggA	p.G734G		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	734						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						GGGCTGCTTTCCCTCCTTGAA	0.398000													17	45					0	0	0.006122	0	0
KCNAB2	8514	broad.mit.edu	37	1	6158556	6158556	+	Silent	SNP	A	A	G	rs148138812	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:6158556A>G	ENST00000164247.1	+	16	1590	c.1026A>G	c.(1024-1026)aaA>aaG	p.K342K	KCNAB2_ENST00000378087.3_Intron|KCNAB2_ENST00000378092.1_Silent_p.K328K|KCNAB2_ENST00000378111.1_Intron|KCNAB2_ENST00000458166.2_Silent_p.K275K|KCNAB2_ENST00000378083.3_Silent_p.K390K|KCNAB2_ENST00000378097.1_Silent_p.K342K|KCNAB2_ENST00000352527.1_Silent_p.K328K|KCNAB2_ENST00000341524.1_Silent_p.K342K|KCNAB2_ENST00000602612.1_3'UTR	NM_001199860.1	NP_001186789.1	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 2	342						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			large_intestine(1)|lung(4)|skin(3)	8	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTTCCGAAACTGTCATCTT	0.537000													9	35					0	0	0.008291	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85517940	85517940	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:85517940G>A	ENST00000393217.2	+	17	3711	c.3650G>A	c.(3649-3651)cGa>cAa	p.R1217Q		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1217										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		GCACACGAACGAGGGGATGTA	0.388000													14	40					0	0	0.016723	0	0
HNRNPM	4670	broad.mit.edu	37	19	8536242	8536242	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:8536242C>T	ENST00000348943.3	+	11	1043	c.811C>T	c.(811-813)Cca>Tca	p.P271S	HNRNPM_ENST00000325495.4_Missense_Mutation_p.P310S	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	310	RRM 2.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						GGGGTTAGGACCAGGAGGGCA	0.478000													28	19					0	0	0.010818	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325035	150325035	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:150325035C>T	ENST00000328902.5	-	3	867	c.651G>A	c.(649-651)gaG>gaA	p.E217E	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	217							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTTCAACTTTCTCCATGAGCT	0.517000													96	173					0	0	0.014410	0	0
IMPG1	3617	broad.mit.edu	37	6	76751689	76751689	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:76751689G>A	ENST00000369950.3	-	2	411	c.222C>T	c.(220-222)ttC>ttT	p.F74F	IMPG1_ENST00000369963.3_Intron	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	74					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CCCCCGTTGGGAAAAATGCGG	0.368000													13	23					0	0	0.016723	0	0
TIMP4	7079	broad.mit.edu	37	3	12198884	12198884	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:12198884C>T	ENST00000287814.4	-	2	748		c.e2+1		SYN2_ENST00000432424.2_RNA	NM_003256.3	NP_003247.1	Q99727	TIMP4_HUMAN	TIMP metallopeptidase inhibitor 4								metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11						CCCCCATGTACCTTTATCTGT	0.527000													11	206					0	0	0.010729	0	0
STEAP3	55240	broad.mit.edu	37	2	120005431	120005431	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:120005431C>T	ENST00000354888.5	+	4	1173	c.669C>T	c.(667-669)ttC>ttT	p.F223F	STEAP3_ENST00000450943.2_Silent_p.F223F|STEAP3_ENST00000393107.2_Silent_p.F223F|STEAP3_ENST00000425223.2_Silent_p.F223F|STEAP3-AS1_ENST00000454260.1_RNA|STEAP3_ENST00000409811.1_Silent_p.F223F|STEAP3_ENST00000393110.2_Silent_p.F233F|STEAP3_ENST00000393108.2_Silent_p.F223F|STEAP3_ENST00000393106.2_Silent_p.F223F	NM_182915.2	NP_878919.2	Q658P3	STEA3_HUMAN	STEAP family member 3, metalloreductase	223					apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	17						TGGGGCTCTTCGTCTGCTTCT	0.627000													14	47					0	0	0.003163	0	0
CDC20B	166979	broad.mit.edu	37	5	54416372	54416372	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:54416372C>T	ENST00000296733.1	-	10	1396	c.1222G>A	c.(1222-1224)Gat>Aat	p.D408N	CDC20B_ENST00000334206.5_3'UTR|CDC20B_ENST00000322374.6_Intron|CDC20B_ENST00000381375.2_Missense_Mutation_p.D408N	NM_001170402.1|NM_152623.2	NP_001163873.1|NP_689836.2	Q86Y33	CD20B_HUMAN	cell division cycle 20B	408										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			GGACACCAATCCATGGCCTTT	0.488000													25	96					0	0	0.006320	0	0
TTC3	7267	broad.mit.edu	37	21	38569994	38569994	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:38569994A>G	ENST00000399017.2	+	43	8450	c.5703A>G	c.(5701-5703)aaA>aaG	p.K1901K	TTC3_ENST00000355666.1_Silent_p.K1901K|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000354749.2_Silent_p.K1901K	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1901	Poly-Lys.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				AGAAAAAGAAAAAGGTATTTT	0.294000													5	10					0	0	0.014758	0	0
GPR98	84059	broad.mit.edu	37	5	90046372	90046372	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:90046372C>T	ENST00000405460.2	+	53	11075	c.10979C>T	c.(10978-10980)tCa>tTa	p.S3660L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3660					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTCAGAATTCATTATATAAG	0.358000													41	60					0	0	0.014410	0	0
OR1Q1	158131	broad.mit.edu	37	9	125377550	125377550	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:125377550C>T	ENST00000297913.2	+	1	603	c.534C>T	c.(532-534)ttC>ttT	p.F178F	RP11-64P14.7_ENST00000431442.1_RNA	NM_012364.1	NP_036496.1	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q, member 1	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	17						CCCACTTCTTCTGTGACCTCT	0.493000													20	40					0	0	0.014323	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42832733	42832733	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:42832733C>T	ENST00000314073.5	+	13	2965	c.2789C>T	c.(2788-2790)gCc>gTc	p.A930V	GLTSCR1L_ENST00000394168.1_Missense_Mutation_p.A930V					GLTSCR1-like																		CCTCTGAAGGCCAGTCAGTGC	0.547000													18	65					0	0	0.006122	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15587399	15587399	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:15587399C>T	ENST00000292609.4	-	2	211	c.82G>A	c.(82-84)Gac>Aac	p.D28N	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.D28N			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	28					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						ATGACAGAGTCCATGAGCAGG	0.567000													7	14					0	0	0.003080	0	0
KIF15	56992	broad.mit.edu	37	3	44893415	44893415	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:44893415A>T	ENST00000326047.4	+	33	4092	c.3943A>T	c.(3943-3945)Atg>Ttg	p.M1315L	KIF15_ENST00000425755.1_Missense_Mutation_p.M950L	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	1315					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		GCTGGAAGAAATGTATGAAGA	0.383000													10	37					0	0	0.008291	0	0
TTC31	64427	broad.mit.edu	37	2	74717474	74717474	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:74717474C>T	ENST00000410003.1	+	4	345	c.336C>T	c.(334-336)tcC>tcT	p.S112S	TTC31_ENST00000463189.1_3'UTR|TTC31_ENST00000233623.5_Silent_p.S112S|TTC31_ENST00000442235.2_5'UTR			Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	112							binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9						TCCGCAAGTCCTTCCTGTATC	0.602000													16	47					0	0	0.004007	0	0
ZNF536	9745	broad.mit.edu	37	19	31040061	31040061	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:31040061G>A	ENST00000355537.3	+	4	3682	c.3535G>A	c.(3535-3537)Gat>Aat	p.D1179N		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.D1179N(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGAGAACAACGATGAAGAGGA	0.557000													18	50					0	0	0.008871	0	0
LAMB4	22798	broad.mit.edu	37	7	107674792	107674792	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:107674792C>T	ENST00000388781.3	-	31	4763		c.e31-1		LAMB4_ENST00000205386.4_Splice_Site|LAMB4_ENST00000388780.3_Splice_Site|LAMB4_ENST00000483484.1_Splice_Site	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4						cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TGCTGCTTTCCTAAGGTAAGA	0.328000													16	35					0	0	0.006122	0	0
REG1A	5967	broad.mit.edu	37	2	79349984	79349984	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:79349984G>A	ENST00000233735.1	+	5	442	c.339G>A	c.(337-339)tgG>tgA	p.W113*		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	113	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						GCTGGCACTGGAGCAGTGGGT	0.557000													14	47					0	0	0.006122	0	0
CAD	790	broad.mit.edu	37	2	27465619	27465619	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:27465619C>T	ENST00000264705.4	+	41	6516	c.6354C>T	c.(6352-6354)ttC>ttT	p.F2118F	CAD_ENST00000403525.1_Silent_p.F2055F	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	2118	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TGCGGGCCTTCGTGGCCTCCC	0.657000													17	43					0	0	0.004990	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072668	17072668	+	Missense_Mutation	SNP	G	G	A	rs147789853	by1000genomes	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:17072668G>A	ENST00000359963.3	-	1	1032	c.773C>T	c.(772-774)aCg>aTg	p.T258M		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	258					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AAGACGGGCCGTTGCTGGTGC	0.502000													23	78					0	0	0.014323	0	0
COL4A4	1286	broad.mit.edu	37	2	227892641	227892641	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:227892641C>T	ENST00000396625.3	-	42	4265	c.4058G>A	c.(4057-4059)aGa>aAa	p.R1353K	COL4A4_ENST00000329662.7_Missense_Mutation_p.R1353K	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1353	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GGGCCCTTTTCTCCCTGGAGG	0.458000													8	30					0	0	0.003080	0	0
TRANK1	9881	broad.mit.edu	37	3	36872408	36872408	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:36872408G>A	ENST00000429976.2	-	21	8781	c.8534C>T	c.(8533-8535)tCg>tTg	p.S2845L	TRANK1_ENST00000428977.2_Missense_Mutation_p.S2295L|TRANK1_ENST00000301807.6_Missense_Mutation_p.S2295L			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2845					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CACCATATCCGAAACCCTCTT	0.597000													25	76					0	0	0.018920	0	0
RFPL3	10738	broad.mit.edu	37	22	32756602	32756602	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:32756602G>A	ENST00000249007.4	+	2	942	c.737G>A	c.(736-738)gGg>gAg	p.G246E	RFPL3S_ENST00000382084.4_3'UTR|RFPL3_ENST00000397468.1_Missense_Mutation_p.G217E|RFPL3_ENST00000382088.3_Missense_Mutation_p.G217E|RFPL3S_ENST00000400234.1_3'UTR	NM_001098535.1	NP_001092005.1	O75679	RFPL3_HUMAN	ret finger protein-like 3	246	B30.2/SPRY.						zinc ion binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|stomach(1)	15						CAGCGAGTGGGGATTTTTCTG	0.512000													17	61					0	0	0.006122	0	0
FILIP1	27145	broad.mit.edu	37	6	76022214	76022214	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:76022214G>A	ENST00000393004.2	-	5	3555	c.3334C>T	c.(3334-3336)Ccc>Tcc	p.P1112S	FILIP1_ENST00000237172.7_Missense_Mutation_p.P1112S|FILIP1_ENST00000370020.1_Missense_Mutation_p.P1013S|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	1112										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TGATTCCTGGGAGAGCGAAGG	0.547000													18	25					0	0	0.008871	0	0
CDH23	64072	broad.mit.edu	37	10	73377123	73377123	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:73377123C>T	ENST00000224721.6	+	10	1127	c.1122C>T	c.(1120-1122)ctC>ctT	p.L374L	CDH23_ENST00000398809.4_Silent_p.L369L|CDH23_ENST00000398842.3_Silent_p.L369L|CDH23_ENST00000461841.3_Silent_p.L414L|CDH23_ENST00000299366.7_Silent_p.L414L	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	369	Cadherin 4.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CCCTTCCACTCTTCATCCAGG	0.582000													15	35					0	0	0.003163	0	0
MYLK	4638	broad.mit.edu	37	3	123456314	123456314	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:123456314C>T	ENST00000360772.3	-	9	1043	c.665G>A	c.(664-666)gGa>gAa	p.G222E	MYLK_ENST00000360304.3_Missense_Mutation_p.G222E|MYLK_ENST00000346322.5_Missense_Mutation_p.G222E|MYLK_ENST00000359169.1_Missense_Mutation_p.G222E|MYLK_ENST00000475616.1_Missense_Mutation_p.G222E			Q15746	MYLK_HUMAN	myosin light chain kinase	222	Ig-like C2-type 2.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TTGGTTGACTCCATGGATTTC	0.547000													35	101					0	0	0.015359	0	0
CDHR1	92211	broad.mit.edu	37	10	85973996	85973996	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:85973996C>T	ENST00000372117.3	+	17	2302	c.2199C>T	c.(2197-2199)gtC>gtT	p.V733V	CDHR1_ENST00000332904.3_Intron|CDHR1_ENST00000440770.2_Silent_p.V437V	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	733					homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						CTAACAAGGTCCTGCCAATGC	0.642000													20	48					0	0	0.016522	0	0
SUCNR1	56670	broad.mit.edu	37	3	151598398	151598398	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:151598398A>T	ENST00000362032.4	+	3	172	c.67A>T	c.(67-69)Aag>Tag	p.K23*	RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_033050.4	NP_149039.2	Q9BXA5	SUCR1_HUMAN	succinate receptor 1	23						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	14			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)		Succinic acid(DB00139)	TGCCCTGGAAAAGTACTACCT	0.413000													15	51					0	0	0.003163	0	0
SDR16C5	195814	broad.mit.edu	37	8	57224829	57224829	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:57224829C>T	ENST00000522671.1	-	3	1083	c.352G>A	c.(352-354)Gat>Aat	p.D118N	SDR16C5_ENST00000303749.3_Missense_Mutation_p.D118N|SDR16C5_ENST00000396721.2_Intron			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	118					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						ATGGAAACATCGCCGACTTCT	0.368000													21	34					0	0	0.014323	0	0
SORCS3	22986	broad.mit.edu	37	10	106974211	106974211	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:106974211T>C	ENST00000369701.3	+	18	2614	c.2387T>C	c.(2386-2388)aTt>aCt	p.I796T	SORCS3_ENST00000369699.4_Missense_Mutation_p.I82T	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	796						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TATCGGCGGATTGTGTCCAAC	0.493000													19	51					0	0	0.012319	0	0
PMFBP1	83449	broad.mit.edu	37	16	72170436	72170436	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:72170436C>T	ENST00000537465.1	-	9	1272	c.1114G>A	c.(1114-1116)Gat>Aat	p.D372N	PMFBP1_ENST00000355636.6_Missense_Mutation_p.D227N|PMFBP1_ENST00000237353.10_Missense_Mutation_p.D372N			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	372										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				ATGTCCTTATCCTTCCTCTCA	0.552000													19	82					0	0	0.008871	0	0
SLC7A3	84889	broad.mit.edu	37	X	70146735	70146735	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:70146735G>A	ENST00000374299.3	-	9	1587	c.1443C>T	c.(1441-1443)tcC>tcT	p.S481S	SLC7A3_ENST00000298085.4_Silent_p.S481S			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	481					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CAAGCAATGAGGAACAAACAT	0.473000													12	8					0	0	0.013537	0	0
CLINT1	9685	broad.mit.edu	37	5	157232931	157232931	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:157232931C>T	ENST00000523094.1	-	7	1036	c.831G>A	c.(829-831)ggG>ggA	p.G277G	CLINT1_ENST00000296951.5_Silent_p.G277G|CLINT1_ENST00000411809.2_Silent_p.G295G|CLINT1_ENST00000523908.1_Silent_p.G295G|CLINT1_ENST00000530742.1_Silent_p.G277G	NM_001195555.1|NM_001195556.1	NP_001182484.1|NP_001182485.1	Q14677	EPN4_HUMAN	clathrin interactor 1	295					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|urinary_tract(1)	21	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGCTTTGTCCCCTGTGTAAT	0.448000													18	52					0	0	0.012319	0	0
C3	718	broad.mit.edu	37	19	6707097	6707097	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:6707097G>A	ENST00000245907.6	-	17	2327	c.2235C>T	c.(2233-2235)ggC>ggT	p.G745G		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	745					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TCCTGGCCAGGCCCAGGTGGC	0.672000													27	11					0	0	0.007291	0	0
BAGE2	85319	broad.mit.edu	37	21	11039428	11039428	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:11039428C>T	ENST00000470054.1	-	0	775									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTCGGTATTCACTGTATGTT	0.294000													4	38					0	0	0.009096	0	0
TENM3	55714	broad.mit.edu	37	4	183651436	183651436	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:183651436C>T	ENST00000511685.1	+	15	2792	c.2669C>T	c.(2668-2670)cCa>cTa	p.P890L	TENM3_ENST00000406950.2_Missense_Mutation_p.P890L|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3									p.P890Q(2)									TTCCATTACCCAGAATATGGA	0.418000													21	56					0	0	0.012319	0	0
TAF5L	27097	broad.mit.edu	37	1	229730512	229730512	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:229730512G>A	ENST00000258281.2	-	5	1467	c.1302C>T	c.(1300-1302)ttC>ttT	p.F434F	TAF5L_ENST00000366676.1_Silent_p.F434F	NM_014409.3	NP_055224.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	434					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				AATTAGGGTGGAATTTGACAC	0.592000													23	141					0	0	0.021523	0	0
DYRK4	8798	broad.mit.edu	37	12	4708873	4708873	+	Splice_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:4708873G>A	ENST00000540757.2	+	8	860	c.699_splice	c.e8-1	p.E234_splice	DYRK4_ENST00000010132.5_Splice_Site_p.E234_splice|DYRK4_ENST00000543431.1_Splice_Site_p.E234_splice	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	234	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			TTCTCTCTAGGAAAATATAGT	0.448000													16	55					0	0	0.004990	0	0
TDRD6	221400	broad.mit.edu	37	6	46659159	46659159	+	Silent	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:46659159T>C	ENST00000544460.1	+	1	3548	c.3294T>C	c.(3292-3294)tgT>tgC	p.C1098C	TDRD6_ENST00000316081.6_Silent_p.C1098C	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1098					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			CTGTCAGATGTTCATTATCTG	0.363000													28	116					0	0	0.007291	0	0
OR52N2	390077	broad.mit.edu	37	11	5842474	5842474	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:5842474G>A	ENST00000317037.2	+	1	931	c.909G>A	c.(907-909)caG>caA	p.Q303Q	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCAGATTCAGGAAGGTGTAA	0.373000													10	40					0	0	0.006214	0	0
HYDIN	54768	broad.mit.edu	37	16	71220731	71220731	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:71220731C>T	ENST00000393567.2	-	2	218	c.68G>A	c.(67-69)gGa>gAa	p.G23E	HYDIN_ENST00000448089.2_Missense_Mutation_p.G23E|HYDIN_ENST00000541601.1_Missense_Mutation_p.G40E|HYDIN_ENST00000538248.1_Missense_Mutation_p.G50E|HYDIN_ENST00000393550.2_Missense_Mutation_p.G23E|HYDIN_ENST00000288168.10_Missense_Mutation_p.G40E|HYDIN_ENST00000321489.5_Missense_Mutation_p.G23E|HYDIN_ENST00000448691.1_Missense_Mutation_p.G23E	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	23										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GCTTTGAAATCCTTTGAACAT	0.383000													7	23					0	0	0.001984	0	0
MEGF9	1955	broad.mit.edu	37	9	123367702	123367702	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:123367702C>T	ENST00000373930.3	-	6	1686	c.1575G>A	c.(1573-1575)gtG>gtA	p.V525V	MEGF9_ENST00000426959.1_Silent_p.V562V	NM_001080497.2	NP_001073966.2	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	525						integral to membrane	calcium ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|upper_aerodigestive_tract(1)	16						TTAGCAGCACCACAACAATGA	0.428000													22	59					0	0	0.014323	0	0
CDC7	8317	broad.mit.edu	37	1	91967356	91967356	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:91967356T>A	ENST00000428239.1	+	2	342	c.83T>A	c.(82-84)tTa>tAa	p.L28*	CDC7_ENST00000497611.1_3'UTR|CDC7_ENST00000430031.2_Nonsense_Mutation_p.L28*|CDC7_ENST00000234626.6_Nonsense_Mutation_p.L28*	NM_001134420.1	NP_001127892.1	O00311	CDC7_HUMAN	cell division cycle 7	28					cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|stomach(2)	23		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		GAAGGCTCTTTAAAAAAAAAC	0.403000													5	142					0	0	0.014758	0	0
TMEM209	84928	broad.mit.edu	37	7	129832632	129832632	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:129832632G>A	ENST00000397622.2	-	6	727	c.605C>T	c.(604-606)cCg>cTg	p.P202L	TMEM209_ENST00000336804.8_Missense_Mutation_p.P201L|TMEM209_ENST00000462753.1_Missense_Mutation_p.P201L|TMEM209_ENST00000473456.1_Missense_Mutation_p.P202L|RP11-775D22.3_ENST00000483283.1_RNA	NM_032842.3	NP_116231.2	Q96SK2	TM209_HUMAN	transmembrane protein 209	202	Ser-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	12	Melanoma(18;0.0435)					GGTAGGGTACGGAGAAGGAGG	0.408000													7	54					0	0	0.003080	0	0
NEBL	10529	broad.mit.edu	37	10	21120162	21120162	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:21120162A>C	ENST00000377122.4	-	16	2030	c.1634T>G	c.(1633-1635)aTc>aGc	p.I545S	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	545					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGCTCGAAGGATATCTGGGAT	0.378000													14	31					0	0	0.003163	0	0
SCN1A	6323	broad.mit.edu	37	2	166870329	166870329	+	Silent	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:166870329C>A	ENST00000423058.2	-	18	3647	c.3630G>T	c.(3628-3630)acG>acT	p.T1210T	SCN1A_ENST00000409050.1_Silent_p.T1182T|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Silent_p.T1210T|SCN1A_ENST00000375405.3_Silent_p.T1199T	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1210			T -> K (in SMEI; dbSNP:rs121918738).			voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTCGGAAACACGTCCTTCTCA	0.398000													4	20					0.00909568	0.00937214	0.009096	1	0
COL4A4	1286	broad.mit.edu	37	2	227872752	227872752	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:227872752G>A	ENST00000396625.3	-	47	4998	c.4791C>T	c.(4789-4791)atC>atT	p.I1597I	COL4A4_ENST00000329662.7_Silent_p.I1594I	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1597	Collagen IV NC1.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ATGAATACCCGATCCAGAGGC	0.612000													11	17					0	0	0.016723	0	0
ATP7A	538	broad.mit.edu	37	X	77301936	77301936	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:77301936A>G	ENST00000341514.6	+	23	4527	c.4372A>G	c.(4372-4374)Aat>Gat	p.N1458D	ATP7A_ENST00000343533.5_Missense_Mutation_p.N1380D|ATP7A_ENST00000350425.4_Missense_Mutation_p.N461D	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1458					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						CCGGATTGTTAATTATAGCAG	0.443000													75	51					0	0	0.014410	0	0
CD36	948	broad.mit.edu	37	7	80285980	80285980	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:80285980A>G	ENST00000435819.1	+	7	929	c.245A>G	c.(244-246)aAc>aGc	p.N82S	CD36_ENST00000538969.1_Missense_Mutation_p.N82S|CD36_ENST00000432207.1_Missense_Mutation_p.N82S|CD36_ENST00000534394.1_Missense_Mutation_p.N6S|CD36_ENST00000309881.7_Missense_Mutation_p.N82S|CD36_ENST00000433696.2_Missense_Mutation_p.N82S|CD36_ENST00000394788.3_Missense_Mutation_p.N82S|CD36_ENST00000441109.2_3'UTR|CD36_ENST00000447544.2_Missense_Mutation_p.N82S|CD36_ENST00000544133.1_Missense_Mutation_p.N82S			P16671	CD36_HUMAN	CD36 molecule (thrombospondin receptor)	82					cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|large_intestine(1)|lung(6)|ovary(1)	21						AACAGCAGCAACATTCAAGTT	0.388000													7	17					0	0	0.001984	0	0
ATP12A	479	broad.mit.edu	37	13	25262581	25262581	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:25262581T>C	ENST00000218548.6	+	4	686	c.353T>C	c.(352-354)cTc>cCc	p.L118P	ATP12A_ENST00000381946.3_Missense_Mutation_p.L118P	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	118					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TTCTCTATCCTCCTGTGGGTG	0.592000													16	370					0	0	0.008871	0	0
FH	2271	broad.mit.edu	37	1	241661172	241661172	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:241661172A>G	ENST00000366560.3	-	10	1527	c.1489T>C	c.(1489-1491)Ttt>Ctt	p.F497L		NM_000143.3	NP_000134.2	P07954	FUMH_HUMAN	fumarate hydratase	497					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(2)	26	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		CATTCGTCAAACTGCTCTGCT	0.363000			"""Mis, N, F"""			"""lieomyomatosis, renal"""			Hereditary Leiomyomatosis and Renal Cell Cancer				3	21					0	0	0.004672	0	0
ANKRD30BP3	338579	broad.mit.edu	37	10	45652235	45652235	+	RNA	SNP	C	C	G	rs149362183		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:45652235C>G	ENST00000427229.2	+	0	1749																											GAAGGAACATCTGAAGGAACA	0.478000													3	8					0	0	0.014758	0	0
PTPRB	5787	broad.mit.edu	37	12	70928675	70928675	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:70928675G>A	ENST00000334414.6	-	30	6186	c.6142C>T	c.(6142-6144)Ctg>Ttg	p.L2048L	RP11-588H23.3_ENST00000549460.1_RNA|PTPRB_ENST00000538708.1_Silent_p.L1740L|PTPRB_ENST00000550857.1_Silent_p.L1740L|PTPRB_ENST00000550358.1_Silent_p.L1960L|RP11-588H23.3_ENST00000547656.1_RNA|RP11-588H23.3_ENST00000546836.1_RNA|RP11-588H23.3_ENST00000551438.1_RNA|PTPRB_ENST00000451516.2_Silent_p.L1740L|RP11-588H23.3_ENST00000548687.1_RNA|PTPRB_ENST00000261266.5_Silent_p.L1830L	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1830					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.L1830M(2)|p.L2048M(1)		breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGCATCTGCAGGATGAGGTCC	0.502000													11	30					0	0	0.010729	0	0
MISP	126353	broad.mit.edu	37	19	758060	758060	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:758060G>A	ENST00000215582.6	+	2	1217	c.1114G>A	c.(1114-1116)Gtg>Atg	p.V372M		NM_173481.2	NP_775752.1			mitotic spindle positioning																		GGGCCTGCACGTGGGCCGGGC	0.701000													8	8					0	0	0.006214	0	0
OR5H1	26341	broad.mit.edu	37	3	97852022	97852022	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:97852022G>A	ENST00000354565.2	+	1	481	c.481G>A	c.(481-483)Gga>Aga	p.G161R	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						AATCCATGAAGGATTTTTATT	0.358000													3	21					0	0	0.004672	0	0
XIST	7503	broad.mit.edu	37	X	73050952	73050952	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:73050952G>A	ENST00000429829.1	-	0	11730					NR_001564.2																						CTGGGACCAGGAAAGTATCTT	0.463000													7	9					0	0	0.004482	0	0
NOTCH1	4851	broad.mit.edu	37	9	139410075	139410075	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:139410075G>A	ENST00000277541.6	-	11	1838	c.1763C>T	c.(1762-1764)aCc>aTc	p.T588I		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	588	EGF-like 15; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCAGAGGCAGGTGAAGGTGGC	0.692000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			5	12					0	0	0.014758	0	0
DCAKD	79877	broad.mit.edu	37	17	43111675	43111675	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:43111675G>A	ENST00000452796.2	-	2	451	c.196C>T	c.(196-198)Cgc>Tgc	p.R66C	DCAKD_ENST00000588499.1_Missense_Mutation_p.R66C|DCAKD_ENST00000310604.4_Missense_Mutation_p.R66C|DCAKD_ENST00000342350.5_Missense_Mutation_p.R66C|DCAKD_ENST00000588295.1_5'UTR			Q8WVC6	DCAKD_HUMAN	dephospho-CoA kinase domain containing	66	DPCK.				coenzyme A biosynthetic process		ATP binding|dephospho-CoA kinase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(2)|skin(1)	6		Prostate(33;0.155)				AGGACCTTGCGATTTATGTCG	0.597000													14	68					0	0	0.020292	0	0
OR5W2	390148	broad.mit.edu	37	11	55681905	55681905	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:55681905C>T	ENST00000344514.1	-	1	153	c.154G>A	c.(154-156)Gat>Aat	p.D52N		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D52Y(1)		breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGTTGGTAATCCATTCTGATT	0.383000													9	32					0	0	0.004482	0	0
CREB3L2	64764	broad.mit.edu	37	7	137593039	137593039	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:137593039G>A	ENST00000330387.6	-	5	1078	c.727C>T	c.(727-729)Ccc>Tcc	p.P243S	CREB3L2_ENST00000456390.1_Missense_Mutation_p.P243S	NM_194071.3	NP_919047.2	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2	243					chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						AGGGCGGAGGGGGCCCGGGGT	0.652000			T	FUS	fibromyxoid sarcoma								3	3					0	0	0.009096	0	0
MOXD1	26002	broad.mit.edu	37	6	132641827	132641827	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:132641827C>T	ENST00000367963.3	-	9	1424	c.1305_splice	c.e9-1	p.G436_splice	MOXD1_ENST00000489128.1_5'UTR|MOXD1_ENST00000336749.3_Splice_Site_p.G368_splice	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	436					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		AGGTTATCTCCCTGAAACATA	0.318000													6	8					0	0	0.001168	0	0
GSG1	83445	broad.mit.edu	37	12	13238026	13238026	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:13238026G>A	ENST00000337630.6	-	6	857	c.790C>T	c.(790-792)Cgg>Tgg	p.R264W	GSG1_ENST00000537302.1_Missense_Mutation_p.R236W|GSG1_ENST00000457134.2_Missense_Mutation_p.R213W|GSG1_ENST00000396302.3_3'UTR|GSG1_ENST00000351606.6_3'UTR|GSG1_ENST00000396310.2_Missense_Mutation_p.R233W|GSG1_ENST00000432710.2_Missense_Mutation_p.R277W|GSG1_ENST00000324458.8_Missense_Mutation_p.R300W	NM_153823.3	NP_722545.2	Q2KHT4	GSG1_HUMAN	germ cell associated 1	287						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GACAGCCGCCGAGGGAAACAC	0.532000													7	15					0	0	0.003080	0	0
KLHL1	57626	broad.mit.edu	37	13	70293603	70293603	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:70293603C>T	ENST00000377844.4	-	9	2672	c.1913G>A	c.(1912-1914)gGg>gAg	p.G638E	KLHL1_ENST00000545028.1_Missense_Mutation_p.G445E	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	638					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TCCGACACCCCCTCTCCTCTT	0.458000													5	13					0	0	0.001168	0	0
EXD2	55218	broad.mit.edu	37	14	69701576	69701576	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:69701576C>T	ENST00000409014.1	+	7	1159	c.502C>T	c.(502-504)Cga>Tga	p.R168*	EXD2_ENST00000492815.1_3'UTR|EXD2_ENST00000449989.1_Nonsense_Mutation_p.R168*|EXD2_ENST00000409949.1_Nonsense_Mutation_p.R168*|EXD2_ENST00000409675.1_Nonsense_Mutation_p.R168*|EXD2_ENST00000409242.1_Nonsense_Mutation_p.R168*|EXD2_ENST00000409018.3_Nonsense_Mutation_p.R293*|EXD2_ENST00000312994.5_Nonsense_Mutation_p.R293*	NM_001193360.1	NP_001180289.1	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	168					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|urinary_tract(1)	14						CATCCCATTTCGAAGCAAAGG	0.443000													16	42					0	0	0.006122	0	0
KRTAP12-1	353332	broad.mit.edu	37	21	46101941	46101941	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:46101941G>A	ENST00000391617.1	-	1	137	c.98C>T	c.(97-99)tCc>tTc	p.S33F	TSPEAR_ENST00000323084.4_Intron	NM_181686.1	NP_859014.1	P59990	KR121_HUMAN	keratin associated protein 12-1	33	14 X 5 AA approximate repeats.					keratin filament				kidney(1)|large_intestine(1)|lung(1)|skin(2)	5						CACGCACACGGAGGACTGGCA	0.677000													16	42					0	0	0.004007	0	0
PPIF	10105	broad.mit.edu	37	10	81111303	81111303	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:81111303C>T	ENST00000225174.3	+	4	447	c.376C>T	c.(376-378)Cct>Tct	p.P126S	PPIF_ENST00000394579.3_Missense_Mutation_p.P126S	NM_005729.3	NP_005720.1	P30405	PPIF_HUMAN	peptidylprolyl isomerase F	126	PPIase cyclophilin-type.				protein folding	membrane fraction|mitochondrial matrix	peptidyl-prolyl cis-trans isomerase activity			endometrium(2)|lung(2)|skin(2)	6	all_cancers(46;0.0893)|Breast(12;8.52e-05)|all_epithelial(25;0.00449)|Prostate(51;0.00985)		Epithelial(14;0.00242)|all cancers(16;0.0069)|Colorectal(32;0.229)		Dimethyl sulfoxide(DB01093)|L-Proline(DB00172)	AAGCCGCTTTCCTGACGAGAA	0.607000													13	43					0	0	0.016723	0	0
DSCR4	10281	broad.mit.edu	37	21	39427068	39427068	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:39427068C>T	ENST00000328264.3	-	3	342	c.238G>A	c.(238-240)Gag>Aag	p.E80K	DSCR4_ENST00000398948.1_Intron	NM_005867.2	NP_005858.1	P56555	DSCR4_HUMAN	Down syndrome critical region gene 4	80								p.E80*(1)		large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	6						TGCTGCCCCTCTCTGGTTCTG	0.428000													20	48					0	0	0.012319	0	0
DOCK3	1795	broad.mit.edu	37	3	51399296	51399296	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:51399296G>A	ENST00000266037.9	+	48	5036	c.5013G>A	c.(5011-5013)atG>atA	p.M1671I		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1671						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		ACAGCCCCATGAACTTGATGG	0.562000													7	10					0	0	0.004482	0	0
XIRP2	129446	broad.mit.edu	37	2	168099883	168099883	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:168099883A>T	ENST00000409195.1	+	9	2070	c.1981A>T	c.(1981-1983)Agg>Tgg	p.R661W	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.R439W|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.R661W	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	486					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTTTGAAACAAGGCCATTGGA	0.438000													12	26					0	0	0.010729	0	0
PYDC2	152138	broad.mit.edu	37	3	191179158	191179158	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:191179158G>A	ENST00000518817.1	+	1	207	c.207G>A	c.(205-207)ggG>ggA	p.G69G		NM_001083308.1	NP_001076777.1	Q56P42	PYDC2_HUMAN	pyrin domain containing 2	69	DAPIN.					cytoplasm|nucleus				breast(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	10						ACTGGGCAGGGATGGCAGCCA	0.527000													22	66					0	0	0.006320	0	0
ACSM2B	348158	broad.mit.edu	37	16	20570715	20570715	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:20570715C>T	ENST00000329697.6	-	3	400	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	ACSM2B_ENST00000414188.2_Missense_Mutation_p.E78K|ACSM2B_ENST00000565322.1_5'UTR|ACSM2B_ENST00000567001.1_Missense_Mutation_p.E78K|ACSM2B_ENST00000565232.1_Missense_Mutation_p.E78K	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	78					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						CACATTAATTCCTTCCCCTTC	0.557000													7	24					0	0	0.001984	0	0
ACVR1C	130399	broad.mit.edu	37	2	158412607	158412607	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:158412607G>A	ENST00000243349.7	-	3	902	c.542C>T	c.(541-543)tCt>tTt	p.S181F	ACVR1C_ENST00000348328.5_Intron|ACVR1C_ENST00000335450.7_Intron|ACVR1C_ENST00000409680.3_Missense_Mutation_p.S131F	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	181	GS.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						TAACATACCAGAGCCAGATCC	0.338000													5	21					0	0	0.001168	0	0
C11orf80	79703	broad.mit.edu	37	11	66563829	66563829	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:66563829C>T	ENST00000360962.4	+	6	718	c.711C>T	c.(709-711)caC>caT	p.H237H	C11orf80_ENST00000346672.4_Silent_p.H82H|C11orf80_ENST00000527368.1_3'UTR|C11orf80_ENST00000540737.1_Silent_p.H71H|C11orf80_ENST00000527634.1_Silent_p.H18H|C11orf80_ENST00000525449.2_Silent_p.H82H|C11orf80_ENST00000532565.2_Silent_p.H18H	NM_024650.3	NP_078926.3	Q8N6T0	CK080_HUMAN	chromosome 11 open reading frame 80	82										autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	14						TCATGGTGCACCCTAAGGTAA	0.358000													4	19					0	0	0.001168	0	0
EFCAB3	146779	broad.mit.edu	37	17	60484436	60484436	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:60484436C>T	ENST00000450662.2	+	10	957	c.886C>T	c.(886-888)Cca>Tca	p.P296S	EFCAB3_ENST00000305286.3_Missense_Mutation_p.P244S	NM_001144933.1	NP_001138405.1	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3	244							calcium ion binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)	17			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			ACCCATCTTTCCATTGTTCCC	0.368000													38	33					0	0	0.010771	0	0
CD163	9332	broad.mit.edu	37	12	7633849	7633849	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:7633849G>A	ENST00000359156.4	-	15	3453	c.3251C>T	c.(3250-3252)tCc>tTc	p.S1084F	CD163_ENST00000541972.1_Missense_Mutation_p.S1072F|CD163_ENST00000396620.3_Missense_Mutation_p.S1117F|CD163_ENST00000432237.2_Missense_Mutation_p.S1084F	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	1084					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						TCCTCTTGAGGAAACTGAAAA	0.428000													20	44					0	0	0.014323	0	0
PVRL3	25945	broad.mit.edu	37	3	110837599	110837599	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:110837599C>T	ENST00000485303.1	+	3	874	c.599C>T	c.(598-600)cCc>cTc	p.P200L	PVRL3_ENST00000493615.1_Missense_Mutation_p.P177L|PVRL3_ENST00000319792.3_Missense_Mutation_p.P200L	NM_001243286.1|NM_015480.2	NP_001230215.1|NP_056295.1	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3	200	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(3)	19						ACTGGAAAACCCGTTGCACAT	0.438000													8	29					0	0	0.004482	0	0
OR4K2	390431	broad.mit.edu	37	14	20344669	20344669	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:20344669G>A	ENST00000298642.2	+	1	279	c.243G>A	c.(241-243)atG>atA	p.M81I		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCCCAAAGATGATTACAGATT	0.413000													29	114					0	0	0.005443	0	0
NEDD9	4739	broad.mit.edu	37	6	11191368	11191368	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:11191368G>A	ENST00000379446.5	-	5	900	c.734C>T	c.(733-735)cCt>cTt	p.P245L	NEDD9_ENST00000504387.1_Missense_Mutation_p.P245L|RP3-510L9.1_ENST00000500636.2_RNA	NM_001271033.1|NM_006403.3	NP_001257962.1|NP_006394.1	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally down-regulated 9	245					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			TCTCATGGGAGGGGGGAAGTC	0.527000													34	52					0	0	0.013726	0	0
LRIG3	121227	broad.mit.edu	37	12	59274408	59274408	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:59274408G>A	ENST00000320743.3	-	13	2042	c.1756C>T	c.(1756-1758)Cac>Tac	p.H586Y	LRIG3_ENST00000379141.4_Missense_Mutation_p.H526Y	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	586	Ig-like C2-type 1.					integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			GAACCAAAGTGATTGGAGATG	0.448000			T	ROS1	NSCLC								17	49					0	0	0.010504	0	0
SSX1	6756	broad.mit.edu	37	X	48116699	48116699	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:48116699C>A	ENST00000376919.3	+	2	159	c.23C>A	c.(22-24)gCa>gAa	p.A8E		NM_001278691.1|NM_005635.2	NP_001265620.1|NP_005626.1	Q16384	SSX1_HUMAN	synovial sarcoma, X breakpoint 1	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|transcription corepressor activity		SS18/SSX1(1169)|SS18L1/SSX1(2)	endometrium(2)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9						GACACCTTTGCAAAGAGACCC	0.552000			T	SS18	synovial sarcoma								26	16					1.36615e-20	1.44388e-20	0.013726	1	0
ABCA10	10349	broad.mit.edu	37	17	67197775	67197775	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:67197775G>A	ENST00000269081.4	-	11	1950	c.1041C>T	c.(1039-1041)ttC>ttT	p.F347F	ABCA10_ENST00000432313.2_Silent_p.F347F|ABCA10_ENST00000416101.2_Silent_p.F347F	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	347					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					AGGACTTAAGGAAAAATAATG	0.328000													35	40					0	0	0.006999	0	0
RBP3	5949	broad.mit.edu	37	10	48382054	48382054	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:48382054C>T	ENST00000224600.4	-	4	3708	c.3595G>A	c.(3595-3597)Ggg>Agg	p.G1199R		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	1199	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	TCCGAGGCCCCCACAGAACGG	0.642000													13	42					0	0	0.020292	0	0
C16orf70	80262	broad.mit.edu	37	16	67168101	67168101	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:67168101C>T	ENST00000219139.3	+	7	669	c.481C>T	c.(481-483)Cag>Tag	p.Q161*	C16orf70_ENST00000569683.1_3'UTR|C16orf70_ENST00000569600.1_Nonsense_Mutation_p.Q161*	NM_025187.3	NP_079463.2	Q9BSU1	CP070_HUMAN	chromosome 16 open reading frame 70	161										cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|skin(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		GGCTTCTCTCCAGATACCCCA	0.483000													28	72					0	0	0.008361	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85450628	85450628	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:85450628G>A	ENST00000393217.2	+	8	2118	c.2057G>A	c.(2056-2058)gGc>gAc	p.G686D		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	686										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CCTTGTGAGGGCTTGAGTAAC	0.343000													15	41					0	0	0.020292	0	0
THSD7A	221981	broad.mit.edu	37	7	11676184	11676184	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:11676184C>T	ENST00000423059.3	-	2	846	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	199	TSP type-1 2.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GCAGAAAATTCAGACACGATG	0.592000										HNSCC(18;0.044)			24	36					0	0	0.021523	0	0
LRIT3	345193	broad.mit.edu	37	4	110791013	110791013	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:110791013C>T	ENST00000327908.3	+	4	1323	c.559C>T	c.(559-561)Cag>Tag	p.Q187*	LRIT3_ENST00000594814.1_Nonsense_Mutation_p.Q370*|LRIT3_ENST00000379920.3_Nonsense_Mutation_p.Q325*|LRIT3_ENST00000409621.2_Nonsense_Mutation_p.Q187*			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	325	LRRCT.					integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		GTGGGATGTCCAGCCGGGATC	0.468000													43	110					0	0	0.014410	0	0
GPR125	166647	broad.mit.edu	37	4	22446706	22446706	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:22446706T>C	ENST00000334304.5	-	6	865	c.596A>G	c.(595-597)cAt>cGt	p.H199R	GPR125_ENST00000502482.1_Missense_Mutation_p.H199R|GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	199	LRRCT.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				TACCCAGCGATGCATCCACAG	0.433000													9	11					0	0	0.006214	0	0
STAB2	55576	broad.mit.edu	37	12	104046436	104046436	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:104046436T>G	ENST00000388887.2	+	12	1564	c.1360T>G	c.(1360-1362)Ttc>Gtc	p.F454V		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	454	FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CACAGACATGTTCTACACCTT	0.393000													9	30					0	0	0.006214	0	0
FRAS1	80144	broad.mit.edu	37	4	79420968	79420968	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:79420968G>A	ENST00000264895.6	+	61	9649	c.9209G>A	c.(9208-9210)aGa>aAa	p.R3070K		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3065	Calx-beta 5.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GTGATCCGCAGAGGGGATCAG	0.552000													29	69					0	0	0.008361	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907419	12907419	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:12907419C>T	ENST00000317869.6	-	2	949	c.724G>A	c.(724-726)Ggg>Agg	p.G242R		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TCTGCACCCCCCTCAGACTCC	0.483000													34	116					0	0	0.015359	0	0
AXDND1	126859	broad.mit.edu	37	1	179494559	179494559	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:179494559G>A	ENST00000367618.3	+	22	2974	c.2587G>A	c.(2587-2589)Gaa>Aaa	p.E863K		NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	863	Glu-rich.									NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						ACTTCAGGAGGAAAATAAAGA	0.343000													5	18					0	0	0.001984	0	0
TCF23	150921	broad.mit.edu	37	2	27375569	27375569	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:27375569G>A	ENST00000296096.5	+	3	609	c.479G>A	c.(478-480)cGa>cAa	p.R160Q		NM_175769.2	NP_786951.1	Q7RTU1	TCF23_HUMAN	transcription factor 23	160					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus				large_intestine(2)|lung(11)|prostate(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGCCGATGCGATCTCGTCTC	0.557000													15	41					0	0	0.004990	0	0
VPS13A	23230	broad.mit.edu	37	9	79824434	79824434	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:79824434C>T	ENST00000360280.3	+	6	741	c.481C>T	c.(481-483)Cgt>Tgt	p.R161C	VPS13A_ENST00000376636.3_Missense_Mutation_p.R161C|VPS13A_ENST00000357409.5_Missense_Mutation_p.R161C|VPS13A_ENST00000376634.4_Missense_Mutation_p.R161C	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	161			R -> H (in a colorectal cancer sample; somatic mutation).		Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TATCCATATTCGTTATGAAGA	0.274000													5	6					0	0	0.014758	0	0
SERPINA3	12	broad.mit.edu	37	14	95081241	95081241	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:95081241G>A	ENST00000553947.1	+	5	1426	c.538G>A	c.(538-540)Gag>Aag	p.E180K	SERPINA3_ENST00000393080.4_Missense_Mutation_p.E155K|SERPINA3_ENST00000467132.1_Missense_Mutation_p.E155K|SERPINA3_ENST00000393078.3_Missense_Mutation_p.E155K|SERPINA3_ENST00000556388.1_Intron			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	155					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		CAGGTTCACGGAGGATGCCAA	0.532000													10	30					0	0	0.006214	0	0
FBXL20	84961	broad.mit.edu	37	17	37441796	37441796	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:37441796G>A	ENST00000264658.6	-	7	689	c.429C>T	c.(427-429)tcC>tcT	p.S143S	FBXL20_ENST00000583610.1_Silent_p.S143S|FBXL20_ENST00000577399.1_Silent_p.S145S|FBXL20_ENST00000394294.3_Intron	NM_032875.2	NP_116264.2	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	143						cytoplasm				breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22			LUAD - Lung adenocarcinoma(14;0.146)			GCCTGAGTTTGGAACAGAACT	0.348000													10	25					0	0	0.016723	0	0
CD244	51744	broad.mit.edu	37	1	160808808	160808808	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:160808808G>A	ENST00000368034.4	-	4	864	c.687C>T	c.(685-687)atC>atT	p.I229I	CD244_ENST00000322302.7_Silent_p.I137I|CD244_ENST00000368033.3_Silent_p.I234I|CD244_ENST00000368032.2_Silent_p.I229I|CD244_ENST00000481677.1_5'UTR	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	234					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TTAGAATCACGATGATCACCA	0.517000													13	57					0	0	0.020292	0	0
AKAP9	10142	broad.mit.edu	37	7	91651607	91651607	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:91651607C>T	ENST00000359028.2	+	14	4154	c.3929C>T	c.(3928-3930)cCa>cTa	p.P1310L	AKAP9_ENST00000358100.2_Missense_Mutation_p.P1310L|AKAP9_ENST00000356239.3_Missense_Mutation_p.P1298L			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1310					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAAAACCTTCCAAAAGAGGAA	0.338000			T	BRAF	papillary thyroid								17	57					0	0	0.014323	0	0
HEATR5B	54497	broad.mit.edu	37	2	37295975	37295975	+	Silent	SNP	C	C	A	rs143552035		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:37295975C>A	ENST00000233099.5	-	8	1121	c.1026G>T	c.(1024-1026)cgG>cgT	p.R342R	HEATR5B_ENST00000354531.2_Silent_p.R342R	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	342							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				TTTGTGTTGCCCGAGGATGGG	0.493000													16	22					2.31682e-05	2.39818e-05	0.003163	1	0
ITIH1	3697	broad.mit.edu	37	3	52819165	52819165	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:52819165G>A	ENST00000273283.2	+	12	1537	c.1513G>A	c.(1513-1515)Gaa>Aaa	p.E505K	ITIH1_ENST00000540715.1_Missense_Mutation_p.E363K|ITIH1_ENST00000537050.1_Missense_Mutation_p.E217K|ITIH1_ENST00000542827.1_Missense_Mutation_p.E505K	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	505	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		ACAGTACTACGAAGGCTCAGA	0.562000													35	100					0	0	0.008740	0	0
ABCC2	1244	broad.mit.edu	37	10	101567916	101567916	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:101567916C>T	ENST00000370449.4	+	13	1858	c.1745C>T	c.(1744-1746)tCc>tTc	p.S582F		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	582	ABC transmembrane type-1 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GCCTTCACCTCCATTACCCTC	0.483000													24	88					0	0	0.018920	0	0
DBF4B	80174	broad.mit.edu	37	17	42828202	42828202	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:42828202C>T	ENST00000315005.3	+	14	1567	c.1429C>T	c.(1429-1431)Ccc>Tcc	p.P477S	DBF4B_ENST00000393547.2_Intron	NM_145663.2	NP_663696.1	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B (S. cerevisiae)	477					cell cycle	nucleus	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)	7		Prostate(33;0.0322)				GCCCCTCCATCCCTCCCAAGA	0.607000													41	69					0	0	0.010771	0	0
IGSF21	84966	broad.mit.edu	37	1	18661492	18661492	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:18661492C>T	ENST00000251296.1	+	4	795	c.412C>T	c.(412-414)Ctc>Ttc	p.L138F		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	138						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CAACATCTTCCTCAACGTCAT	0.587000													8	28					0	0	0.008291	0	0
ACSL3	2181	broad.mit.edu	37	2	223806250	223806250	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:223806250C>T	ENST00000357430.3	+	17	2572	c.2041C>T	c.(2041-2043)Cgt>Tgt	p.R681C	ACSL3_ENST00000392066.3_Missense_Mutation_p.R681C	NM_004457.3	NP_004448.2	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	681					long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding	p.R681C(5)		cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)|skin(2)	22		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	AGTAAAAATTCGTTTGAGTCC	0.378000			T	ETV1	prostate								8	12					0	0	0.004482	0	0
IKZF1	10320	broad.mit.edu	37	7	50444296	50444296	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:50444296G>A	ENST00000331340.3	+	4	381	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K	IKZF1_ENST00000439701.1_Missense_Mutation_p.E76K|IKZF1_ENST00000440768.2_Missense_Mutation_p.E76K|IKZF1_ENST00000357364.4_Missense_Mutation_p.E76K|IKZF1_ENST00000438033.1_Intron|IKZF1_ENST00000343574.5_Intron|IKZF1_ENST00000346667.4_Intron|IKZF1_ENST00000349824.4_Missense_Mutation_p.E76K|IKZF1_ENST00000359197.5_Missense_Mutation_p.E76K	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	76					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(131)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				AATGAATGGGGAAGAATGTGC	0.498000			"""D,T"""	BCL6	"""ALL, DLBCL"""								23	60					0	0	0.014323	0	0
MYH4	4622	broad.mit.edu	37	17	10348312	10348312	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:10348312A>C	ENST00000255381.2	-	37	5557	c.5447T>G	c.(5446-5448)aTc>aGc	p.I1816S	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1816					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CAGTTTCTGGATCTGCTTCTT	0.542000													32	85					0	0	0.015359	0	0
TRIML1	339976	broad.mit.edu	37	4	189063465	189063465	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:189063465C>T	ENST00000332517.3	+	3	704	c.564C>T	c.(562-564)ttC>ttT	p.F188F	RP11-366H4.3_ENST00000501322.2_RNA	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	188					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TGCACCAGTTCCTGAAGGAAG	0.443000													18	42					0	0	0.007413	0	0
HYDIN	54768	broad.mit.edu	37	16	70934932	70934932	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:70934932T>C	ENST00000393567.2	-	53	9173	c.9023A>G	c.(9022-9024)aAc>aGc	p.N3008S		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3008										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CTTCTTGATGTTGACAGGCTT	0.517000													24	145					0	0	0.007835	0	0
ZNF280A	129025	broad.mit.edu	37	22	22869717	22869717	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:22869717G>A	ENST00000302097.3	-	2	490	c.238C>T	c.(238-240)Cgt>Tgt	p.R80C		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	80					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GGATATTGACGGAAGTGGCCT	0.468000													35	81					0	0	0.019004	0	0
SRCAP	10847	broad.mit.edu	37	16	30732570	30732570	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:30732570C>T	ENST00000262518.4	+	21	3699	c.3314C>T	c.(3313-3315)tCc>tTc	p.S1105F	SRCAP_ENST00000395059.2_Missense_Mutation_p.S1105F|SRCAP_ENST00000344771.4_Intron	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1105	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CCAACCTTGTCCCTAAAGCCA	0.617000													37	108					0	0	0.021022	0	0
FMN2	56776	broad.mit.edu	37	1	240371412	240371412	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:240371412C>T	ENST00000319653.9	+	5	3530	c.3300C>T	c.(3298-3300)ccC>ccT	p.P1100P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1100	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCCTCCGCCCCCTCTACCCG	0.736000													26	26					0	0	0.015359	0	0
STK36	27148	broad.mit.edu	37	2	219553455	219553455	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:219553455C>T	ENST00000295709.3	+	12	1695	c.1416C>T	c.(1414-1416)atC>atT	p.I472I	STK36_ENST00000440309.1_Silent_p.I472I|STK36_ENST00000392105.3_Silent_p.I472I|STK36_ENST00000392106.2_Silent_p.I472I	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	472					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CTTCCCACATCCTGCCTGCAT	0.532000													37	131					0	0	0.010771	0	0
NINL	22981	broad.mit.edu	37	20	25498400	25498400	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:25498400G>A	ENST00000278886.6	-	3	339	c.266C>T	c.(265-267)tCt>tTt	p.S89F	NINL_ENST00000422516.1_Missense_Mutation_p.S89F	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	89					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						TGATTCCAAAGAACTACTGTC	0.378000													13	19					0	0	0.020292	0	0
GPR98	84059	broad.mit.edu	37	5	89990391	89990391	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:89990391G>A	ENST00000405460.2	+	33	7914	c.7818G>A	c.(7816-7818)gtG>gtA	p.V2606V		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2606					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAACCTTGGTGGAGCTGATGA	0.463000													56	55					0	0	0.014410	0	0
COL16A1	1307	broad.mit.edu	37	1	32157113	32157113	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:32157113C>T	ENST00000373672.3	-	19	1819	c.1302_splice	c.e19-1	p.G435_splice	COL16A1_ENST00000373668.3_Splice_Site_p.G435_splice|COL16A1_ENST00000271069.6_Splice_Site_p.G435_splice	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	435	Triple-helical region 9 (COL9) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CCAGGGTCTCCCTGGCACAGA	0.662000													8	37					0	0	0.004482	0	0
CIC	23152	broad.mit.edu	37	19	42794405	42794405	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:42794405T>A	ENST00000572681.2	+	11	4280	c.4212T>A	c.(4210-4212)ttT>ttA	p.F1404L	CIC_ENST00000160740.3_Missense_Mutation_p.F495L|CIC_ENST00000575354.2_Missense_Mutation_p.F495L			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	495					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GGAAGGTGTTTTCACCTGTGA	0.617000			"""Mis, F, S"""		oligodendroglioma								35	79					0	0	0.019004	0	0
RBM6	10180	broad.mit.edu	37	3	50097165	50097165	+	Silent	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:50097165C>A	ENST00000443081.1	+	11	2737	c.1818C>A	c.(1816-1818)gcC>gcA	p.A606A	RBM6_ENST00000266022.4_Silent_p.A738A|RBM6_ENST00000422955.1_Silent_p.A216A|RBM6_ENST00000539992.1_Silent_p.A80A|RBM6_ENST00000441115.1_3'UTR|RBM6_ENST00000442092.1_Silent_p.A216A			P78332	RBM6_HUMAN	RNA binding motif protein 6	738					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		TAAACCTGGCCACTGGAAAAC	0.468000													20	43					1.28384e-07	1.33914e-07	0.012319	1	0
LINC00303	284573	broad.mit.edu	37	1	204009447	204009447	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:204009447G>A	ENST00000367207.3	-	0	249																											AGACTGTAGGGGTGAGTTGAT	0.443000													4	17					0	0	0.009096	0	0
HYDIN	54768	broad.mit.edu	37	16	70995865	70995865	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:70995865G>A	ENST00000393567.2	-	38	6115	c.5965C>T	c.(5965-5967)Caa>Taa	p.Q1989*		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1989										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CGGTTACTTTGGAAAATGATT	0.433000													11	37					0	0	0.003163	0	0
KIF15	56992	broad.mit.edu	37	3	44844342	44844342	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:44844342G>A	ENST00000326047.4	+	14	1695	c.1546G>A	c.(1546-1548)Gaa>Aaa	p.E516K	KIF15_ENST00000425755.1_Missense_Mutation_p.E151K	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	516					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		GTATGCTATGGAAAATCATTC	0.383000													14	45					0	0	0.020292	0	0
OR5M1	390168	broad.mit.edu	37	11	56380060	56380060	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:56380060C>T	ENST00000526538.1	-	1	918	c.919G>A	c.(919-921)Gga>Aga	p.G307R		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						AAGGATTTTCCCCTAATCATT	0.378000													12	34					0	0	0.016723	0	0
FAT2	2196	broad.mit.edu	37	5	150946767	150946767	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:150946767C>T	ENST00000261800.5	-	1	1738	c.1726G>A	c.(1726-1728)Gac>Aac	p.D576N		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	576	Cadherin 5.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACTGGCCAGTCTTGGCGGATA	0.443000													81	83					0	0	0.014410	0	0
DTNBP1	84062	broad.mit.edu	37	6	15615570	15615570	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:15615570C>T	ENST00000338950.5	-	6	521	c.416G>A	c.(415-417)tGt>tAt	p.C139Y	DTNBP1_ENST00000355917.3_Missense_Mutation_p.C139Y|DTNBP1_ENST00000344537.5_Missense_Mutation_p.C139Y	NM_183040.2	NP_898861.1	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1	139					actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|skin(2)	14	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			ACACTGCCCACATAAGTCTTC	0.383000									Hermansky-Pudlak syndrome				19	77					0	0	0.016522	0	0
GPR128	84873	broad.mit.edu	37	3	100352130	100352130	+	Missense_Mutation	SNP	G	G	A	rs143646459		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:100352130G>A	ENST00000273352.3	+	4	624	c.356G>A	c.(355-357)cGg>cAg	p.R119Q		NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	119					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						ATGGCAGTCCGGTTGTGCAGT	0.313000													8	48					0	0	0.004482	0	0
OR4K1	79544	broad.mit.edu	37	14	20404491	20404491	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:20404491G>A	ENST00000285600.4	+	1	725	c.666G>A	c.(664-666)ttG>ttA	p.L222L		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CCATCATTTTGATCGGTGTCC	0.433000													8	36					0	0	0.003080	0	0
MOB4	25843	broad.mit.edu	37	2	198415074	198415074	+	Silent	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:198415074T>C	ENST00000323303.4	+	7	765	c.510T>C	c.(508-510)gcT>gcC	p.A170A	MOB4_ENST00000448447.2_Silent_p.A149A|MOB4_ENST00000497443.1_3'UTR|MOB4_ENST00000409916.1_Silent_p.A71A|MOB4_ENST00000409360.1_Silent_p.A138A|MOB4_ENST00000233892.4_Silent_p.A138A|MOB4_ENST00000604458.1_Silent_p.A206A	NM_001202485.1|NM_015387.4	NP_001189414.1|NP_056202.2			MOB family member 4, phocein																		TTTCACATGCTTATTTTCATC	0.318000													10	15					0	0	0.006214	0	0
SALL1	6299	broad.mit.edu	37	16	51175386	51175386	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:51175386C>T	ENST00000440970.1	-	2	887	c.456G>A	c.(454-456)caG>caA	p.Q152Q	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.Q249Q	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	249	Poly-Ser.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GGTGACGAATCTGTTCGATCA	0.537000													32	67					0	0	0.013726	0	0
GLYATL1	92292	broad.mit.edu	37	11	58722355	58722355	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:58722355G>A	ENST00000300079.5	+	5	442	c.392G>A	c.(391-393)aGa>aAa	p.R131K	GLYATL1_ENST00000317391.4_Missense_Mutation_p.R100K|RP11-142C4.6_ENST00000533954.1_RNA	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	100						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	TGGAAACAGAGACTCCAAATC	0.403000													8	13					0	0	0.003080	0	0
PWP2	5822	broad.mit.edu	37	21	45535744	45535744	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:45535744A>G	ENST00000291576.7	+	7	906	c.779A>G	c.(778-780)aAa>aGa	p.K260R		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	260						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		ATCCGGGGAAAAGCCACTCCG	0.627000													6	11					0	0	0.001168	0	0
SULT1C4	27233	broad.mit.edu	37	2	108999630	108999630	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:108999630C>T	ENST00000272452.2	+	4	801	c.475C>T	c.(475-477)Cca>Tca	p.P159S	SULT1C4_ENST00000409309.3_Intron	NM_006588.2	NP_006579.2	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member 4	159					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						TCTTCCTGCTCCAGGAACATG	0.418000													28	64					0	0	0.005443	0	0
AOC1	26	broad.mit.edu	37	7	150554734	150554734	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:150554734G>A	ENST00000493429.1	+	4	1760	c.1176G>A	c.(1174-1176)ccG>ccA	p.P392P	AOC1_ENST00000416793.2_Silent_p.P392P|AOC1_ENST00000467291.1_Silent_p.P392P|AOC1_ENST00000360937.4_Silent_p.P392P					amine oxidase, copper containing 1																		TCGACTGCCCGGAGACCGCCA	0.607000													48	89					0	0	0.014410	0	0
TAOK2	9344	broad.mit.edu	37	16	29999125	29999125	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:29999125C>T	ENST00000308893.4	+	16	4575	c.3532C>T	c.(3532-3534)Cac>Tac	p.H1178Y	TAOK2_ENST00000279394.3_Intron|TAOK2_ENST00000416441.2_Missense_Mutation_p.H1005Y|TAOK2_ENST00000543033.1_Missense_Mutation_p.H1065Y	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	1178					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						GTGGGCCATCCACACACTGGC	0.687000													13	25					0	0	0.016723	0	0
OR6C4	341418	broad.mit.edu	37	12	55945196	55945196	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:55945196G>A	ENST00000394256.2	+	1	214	c.186G>A	c.(184-186)cgG>cgA	p.R62R	RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						TCTTCCTCCGGAATTTCTCCT	0.428000													9	38					0	0	0.006214	0	0
HSD17B3	3293	broad.mit.edu	37	9	99013747	99013747	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:99013747G>A	ENST00000375263.3	-	5	453	c.406C>T	c.(406-408)Cca>Tca	p.P136S	HSD17B3_ENST00000375262.2_Missense_Mutation_p.P136S	NM_000197.1	NP_000188.1	P37058	DHB3_HUMAN	hydroxysteroid (17-beta) dehydrogenase 3	136					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	AGAAGGTTTGGAAGCATTCCG	0.443000													7	40					0	0	0.003080	0	0
ACTN3	89	broad.mit.edu	37	11	66321524	66321524	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:66321524G>A	ENST00000502692.1	+	0	636				ACTN3_ENST00000513398.1_RNA	NM_001258371.1	NP_001245300.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						AGAGATTGTTGACGGGAACCT	0.552000													17	42					0	0	0.006122	0	0
VPS41	27072	broad.mit.edu	37	7	38781671	38781671	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:38781671G>A	ENST00000310301.4	-	25	2227	c.2173C>T	c.(2173-2175)Cta>Tta	p.L725L	VPS41_ENST00000395969.2_Silent_p.L700L	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	725					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						TGAATCAGTAGAATTGGGTCA	0.343000													11	17					0	0	0.008291	0	0
AKAP9	10142	broad.mit.edu	37	7	91691662	91691662	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:91691662C>T	ENST00000359028.2	+	25	6100	c.5875C>T	c.(5875-5877)Cgt>Tgt	p.R1959C	AKAP9_ENST00000491695.1_3'UTR|AKAP9_ENST00000358100.2_Missense_Mutation_p.R1959C|AKAP9_ENST00000356239.3_Missense_Mutation_p.R1947C			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1959	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TATAATAGATCGTCTTGAGCA	0.358000			T	BRAF	papillary thyroid								10	31					0	0	0.010729	0	0
VANGL2	57216	broad.mit.edu	37	1	160390266	160390266	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:160390266C>T	ENST00000368061.2	+	5	1340	c.866C>T	c.(865-867)gCc>gTc	p.A289V	VANGL2_ENST00000483408.1_Intron	NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	289					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TACAACCCTGCCCTCCTCAAC	0.607000													26	89					0	0	0.021523	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21883634	21883634	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:21883634G>C	ENST00000319481.3	-	14	1347	c.1141C>G	c.(1141-1143)Ctc>Gtc	p.L381V	OSBPL1A_ENST00000357041.4_5'UTR	NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	381					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					ATCATTTTGAGAAAGTTGGAA	0.333000													26	98					0	0	0.013726	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147600726	147600726	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:147600726C>T	ENST00000361727.3	+	14	2684	c.2168C>T	c.(2167-2169)cCt>cTt	p.P723L		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	723	Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GGCTCTGGGCCTGGAATCCAG	0.512000										HNSCC(39;0.1)			10	26					0	0	0.010729	0	0
BRAF	673	broad.mit.edu	37	7	140453193	140453193	+	Splice_Site	SNP	T	T	G	rs121913370		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:140453193T>G	ENST00000288602.6	-	15	1802	c.1741_splice	c.e15-1	p.N581_splice		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	581	Protein kinase.		N -> D (in CFC syndrome).|N -> S (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.N581S(9)|p.N581I(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	AAGAAATATATCTGAGGTGTA	0.358000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				6	27					0	0	0.001984	0	0
TMEM119	338773	broad.mit.edu	37	12	108986011	108986011	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:108986011G>A	ENST00000392806.3	-	2	317	c.149C>T	c.(148-150)tCc>tTc	p.S50F		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	50						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						GCTCGGGGAGGAGGCCGACGA	0.716000													6	18					0	0	0.001984	0	0
SAMD9	54809	broad.mit.edu	37	7	92731571	92731571	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:92731571G>A	ENST00000379958.2	-	3	4109	c.3840C>T	c.(3838-3840)ccC>ccT	p.P1280P		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1280						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TATTGTTCCTGGGTTTTAGCA	0.299000													18	38					0	0	0.008871	0	0
TBXA2R	6915	broad.mit.edu	37	19	3595724	3595724	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:3595724G>A	ENST00000375190.4	-	3	1387	c.994C>T	c.(994-996)Ctc>Ttc	p.L332F	TBXA2R_ENST00000411851.3_Intron|TBXA2R_ENST00000589966.1_Missense_Mutation_p.P202L	NM_001060.5|NM_201636.2	NP_001051.1|NP_963998.2	P21731	TA2R_HUMAN	thromboxane A2 receptor	332					platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	TGGGGCTGGAGGGACAGCGAC	0.706000													11	4					0	0	0.010729	0	0
TENM3	55714	broad.mit.edu	37	4	183594300	183594300	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:183594300C>T	ENST00000511685.1	+	7	1377	c.1254C>T	c.(1252-1254)ttC>ttT	p.F418F	TENM3_ENST00000406950.2_Silent_p.F418F					teneurin transmembrane protein 3																		TTCTTAAATTCAATATCTCTC	0.433000													10	27					0	0	0.010729	0	0
GTF3C2	2976	broad.mit.edu	37	2	27558793	27558793	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:27558793G>A	ENST00000359541.2	-	9	1887	c.1458C>T	c.(1456-1458)acC>acT	p.T486T	AC109828.1_ENST00000416453.2_RNA|AC109828.1_ENST00000585326.1_RNA|GTF3C2_ENST00000264720.3_Silent_p.T486T			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	486						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTTCCGAGGGGTGCCTGGAA	0.552000													10	29					0	0	0.010729	0	0
CCDC88C	440193	broad.mit.edu	37	14	91770241	91770241	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:91770241C>T	ENST00000389857.6	-	20	3525	c.3439G>A	c.(3439-3441)Gag>Aag	p.E1147K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1147					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TTCTCCGTCTCCTTGGCCGTG	0.652000													21	58					0	0	0.016522	0	0
SMAD9	4093	broad.mit.edu	37	13	37427614	37427614	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:37427614C>T	ENST00000379826.4	-	6	1544	c.1202G>A	c.(1201-1203)gGc>gAc	p.G401D	SMAD9_ENST00000399275.2_Missense_Mutation_p.G401D|SMAD9_ENST00000350148.5_Missense_Mutation_p.G364D	NM_001127217.2	NP_001120689.1	O15198	SMAD9_HUMAN	SMAD family member 9	401	MH2.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)	18		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		GACTTCAAAGCCGTGGTGAAC	0.493000													16	23					0	0	0.004007	0	0
NCOA2	10499	broad.mit.edu	37	8	71069449	71069449	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:71069449G>A	ENST00000452400.2	-	11	1332	c.1151C>T	c.(1150-1152)cCg>cTg	p.P384L		NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	384					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity	p.P384L(1)	PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			AGTCAGATCCGGATTCATCAC	0.413000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								14	39					0	0	0.004990	0	0
OR2G6	391211	broad.mit.edu	37	1	248685273	248685273	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:248685273C>T	ENST00000343414.4	+	1	358	c.326C>T	c.(325-327)tCg>tTg	p.S109L		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S109L(1)		NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGGTTGGGCTCGTCTGAGTGT	0.547000													29	93					0	0	0.010818	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67221645	67221645	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:67221645C>T	ENST00000314586.6	-	5	763	c.523G>A	c.(523-525)Gat>Aat	p.D175N	EXOC3L1_ENST00000562887.1_Intron	NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	175	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						GCCCACGTATCCTCTCGCAGC	0.617000													12	60					0	0	0.013537	0	0
PPIG	9360	broad.mit.edu	37	2	170470973	170470973	+	Splice_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:170470973G>A	ENST00000260970.3	+	8	597		c.e8-1		PPIG_ENST00000409714.3_Splice_Site|PPIG_ENST00000448752.2_Splice_Site|PPIG_ENST00000462903.1_Splice_Site	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)						protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	ATTTCCAAAAGAACAACGAAA	0.244000													20	45					0	0	0.018920	0	0
KIAA1614	57710	broad.mit.edu	37	1	180910413	180910413	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:180910413C>G	ENST00000367588.4	+	7	3206	c.3151C>G	c.(3151-3153)Ctg>Gtg	p.L1051V	KIAA1614_ENST00000461346.1_3'UTR|KIAA1614_ENST00000367587.1_Missense_Mutation_p.L672V	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	1051	Ser-rich.									NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						GTTACAATCCCTGCACCCGGT	0.637000													12	54					0	0	0.020292	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043181	71043181	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:71043181G>A	ENST00000272367.2	-	4	1408	c.1332C>T	c.(1330-1332)cgC>cgT	p.R444R	CLEC4F_ENST00000426626.1_Silent_p.R444R	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	444					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						GGGTCTTCAGGCGACTCTGCT	0.522000													15	45					0	0	0.003163	0	0
OR2L2	26246	broad.mit.edu	37	1	248202104	248202104	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:248202104G>A	ENST00000366479.2	+	1	631	c.535G>A	c.(535-537)Gat>Aat	p.D179N	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TTTTTTCTGTGATGTTCCAGC	0.443000													97	103					0	0	0.014410	0	0
STPG2	285555	broad.mit.edu	37	4	98865133	98865133	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:98865133C>T	ENST00000295268.3	-	8	1048	c.959G>A	c.(958-960)gGa>gAa	p.G320E		NM_174952.2	NP_777612.1			sperm-tail PG-rich repeat containing 2																		ATCAGAAATTCCCACACCCTG	0.328000													14	31					0	0	0.006122	0	0
FBN3	84467	broad.mit.edu	37	19	8194148	8194148	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:8194148C>T	ENST00000600128.1	-	17	2560	c.2146G>A	c.(2146-2148)Ggt>Agt	p.G716S	FBN3_ENST00000601739.1_Missense_Mutation_p.G716S|FBN3_ENST00000270509.2_Missense_Mutation_p.G716S			Q75N90	FBN3_HUMAN	fibrillin 3	716	EGF-like 8; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CCTGAGGCACCTGCCTCATAA	0.627000													23	21					0	0	0.014323	0	0
IGKV1-9	28941	broad.mit.edu	37	2	89309711	89309711	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:89309711C>T	ENST00000493819.1	-	0	176																											GATGGTGACTCTGTCTCCTAC	0.478000													43	128					0	0	0.011902	0	0
GRM8	2918	broad.mit.edu	37	7	126173342	126173342	+	Silent	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:126173342G>T	ENST00000339582.2	-	9	2902	c.2094C>A	c.(2092-2094)atC>atA	p.I698I	GRM8_ENST00000444921.2_Silent_p.I698I|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Silent_p.I698I			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	698					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GGCTGAAGGTGATCACCAGCT	0.507000										HNSCC(24;0.065)			22	34					1.2644e-06	1.31685e-06	0.010504	1	0
ZFP42	132625	broad.mit.edu	37	4	188924723	188924723	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:188924723G>A	ENST00000326866.4	+	4	1170	c.762G>A	c.(760-762)aaG>aaA	p.K254K	ZFP42_ENST00000509524.1_Silent_p.K254K	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	254					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GGTGCGGAAAGCGCTTCTCTC	0.493000													11	34					0	0	0.010729	0	0
CHD5	26038	broad.mit.edu	37	1	6206417	6206417	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:6206417G>A	ENST00000262450.3	-	11	1756	c.1657C>T	c.(1657-1659)Ccc>Tcc	p.P553S	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	553	Chromo 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TAGTCAAAGGGGGGCGGCTCA	0.552000													12	55					0	0	0.020292	0	0
ZSWIM1	90204	broad.mit.edu	37	20	44511516	44511516	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:44511516C>A	ENST00000372523.1	+	2	380	c.285C>A	c.(283-285)ttC>ttA	p.F95L	ZSWIM1_ENST00000372520.1_Missense_Mutation_p.F95L	NM_080603.4	NP_542170.3	Q9BR11	ZSWM1_HUMAN	zinc finger, SWIM-type containing 1	95							zinc ion binding			breast(1)|endometrium(3)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13		Myeloproliferative disorder(115;0.028)				TATATACCTTCCTGGTGGATG	0.517000													20	48					1.01871e-10	1.06917e-10	0.008871	1	0
TAOK1	57551	broad.mit.edu	37	17	27869900	27869900	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:27869900C>T	ENST00000261716.3	+	20	3385	c.2866C>T	c.(2866-2868)Cga>Tga	p.R956*	TAOK1_ENST00000536202.1_Nonsense_Mutation_p.R808*	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	956					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			AGGGGTACCTCGAGGTAGCAG	0.632000													19	23					0	0	0.007413	0	0
AHR	196	broad.mit.edu	37	7	17379741	17379741	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:17379741T>G	ENST00000242057.4	+	10	2935	c.2292T>G	c.(2290-2292)tgT>tgG	p.C764W		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	764					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					CTCAGACATGTTATGCTGGGG	0.463000													16	40					0	0	0.010504	0	0
MYH15	22989	broad.mit.edu	37	3	108219053	108219053	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:108219053G>A	ENST00000273353.3	-	5	524	c.468C>T	c.(466-468)gtC>gtT	p.V156V		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	156	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AGGCGGCCATGACTTCTTTCT	0.468000													11	28					0	0	0.020292	0	0
CLSTN3	9746	broad.mit.edu	37	12	7290645	7290645	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:7290645C>T	ENST00000537408.1	+	7	1879	c.1341C>T	c.(1339-1341)ttC>ttT	p.F447F	CLSTN3_ENST00000266546.6_Silent_p.F435F			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	435					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						CAGTCAAGTTCCTCTGGAAGC	0.587000													14	52					0	0	0.020292	0	0
SNHG14	104472715	broad.mit.edu	37	15	25488604	25488604	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:25488604G>A	ENST00000453082.2	+	0	2232					NR_003343.1																						CTTGTGTTGGGCCTGCTGTTC	0.592000													3	11					0	0	0.004672	0	0
RBMXL1	494115	broad.mit.edu	37	1	89448887	89448887	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:89448887G>A	ENST00000399794.2	-	3	1338	c.623C>T	c.(622-624)tCc>tTc	p.S208F	CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000370491.3_Intron|CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000260508.4_Intron|RBMXL1_ENST00000321792.5_Missense_Mutation_p.S208F	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	208							nucleotide binding|RNA binding										ATCTCTTGGGGACAAATAAAC	0.463000													36	124					0	0	0.007835	0	0
SPOPL	339745	broad.mit.edu	37	2	139308526	139308526	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:139308526C>T	ENST00000280098.4	+	4	633	c.254C>T	c.(253-255)tCc>tTc	p.S85F		NM_001001664.2	NP_001001664.1	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	85	MATH.					nucleus				breast(2)|cervix(2)|endometrium(2)|large_intestine(2)|lung(11)|skin(2)	21				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GACTACTTGTCCTTATATTTG	0.358000													14	49					0	0	0.020292	0	0
SLC4A5	57835	broad.mit.edu	37	2	74460589	74460589	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:74460589C>T	ENST00000394019.2	-	23	2932	c.2535G>A	c.(2533-2535)ctG>ctA	p.L845L	SLC4A5_ENST00000358683.4_Silent_p.L743L|SLC4A5_ENST00000346834.4_Silent_p.L845L|SLC4A5_ENST00000357822.5_Silent_p.L845L|SLC4A5_ENST00000359484.4_Silent_p.L743L|SLC4A5_ENST00000483195.1_5'UTR|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Silent_p.L845L|SLC4A5_ENST00000377632.1_Silent_p.L845L|SLC4A5_ENST00000377634.4_Silent_p.L845L	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	845						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CCATGAAGATCAGGATGGTCA	0.572000													15	37					0	0	0.004007	0	0
SLC11A2	4891	broad.mit.edu	37	12	51385436	51385436	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:51385436G>A	ENST00000394904.3	-	14	1503	c.1454C>T	c.(1453-1455)cCc>cTc	p.P485L	SLC11A2_ENST00000545993.2_Missense_Mutation_p.P452L|SLC11A2_ENST00000546743.1_Missense_Mutation_p.P377L|SLC11A2_ENST00000262052.5_Missense_Mutation_p.P456L|SLC11A2_ENST00000541174.2_Missense_Mutation_p.P456L|SLC11A2_ENST00000547198.1_Missense_Mutation_p.P456L|SLC11A2_ENST00000262051.7_Missense_Mutation_p.P456L|SLC11A2_ENST00000547688.1_Missense_Mutation_p.P485L	NM_001174125.1	NP_001167596.1	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	456					activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			breast(2)|cervix(1)|endometrium(3)|kidney(16)|large_intestine(4)|lung(9)|upper_aerodigestive_tract(1)	36						TGTGAGGATGGGTATGAGAGC	0.458000													7	21					0	0	0.003080	0	0
CPT1A	1374	broad.mit.edu	37	11	68529012	68529012	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:68529012G>A	ENST00000265641.5	-	16	2173	c.2019C>T	c.(2017-2019)ttC>ttT	p.F673F	CPT1A_ENST00000539743.1_Silent_p.F673F|CPT1A_ENST00000540367.1_Silent_p.F673F|CPT1A_ENST00000376618.2_Silent_p.F673F	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	673					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CTTCCTTAAGGAAAGGGGACT	0.443000													30	112					0	0	0.009535	0	0
NUTF2	10204	broad.mit.edu	37	16	67904742	67904742	+	Silent	SNP	C	C	T	rs34777458	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:67904742C>T	ENST00000219169.4	+	5	593	c.310C>T	c.(310-312)Cta>Tta	p.L104L	NUTF2_ENST00000569436.2_Silent_p.L104L|CTC-479C5.16_ENST00000587481.1_RNA|NUTF2_ENST00000568396.2_Silent_p.L104L	NM_005796.1	NP_005787.1	P61970	NTF2_HUMAN	nuclear transport factor 2	104	NTF2.				protein transport	cytosol|nuclear pore	protein binding|transporter activity			kidney(1)|lung(2)|upper_aerodigestive_tract(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00443)|Epithelial(162;0.0199)|all cancers(182;0.129)		CCAGATGTTCCTATTAAAGAA	0.498000													22	113					0	0	0.004656	0	0
OR4E2	26686	broad.mit.edu	37	14	22134166	22134166	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:22134166G>A	ENST00000408935.1	+	1	870	c.870G>A	c.(868-870)agG>agA	p.R290R		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		ACACCTTGAGGAATGAGGAGG	0.448000													6	16					0	0	0.001984	0	0
DNPEP	23549	broad.mit.edu	37	2	220239598	220239598	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:220239598G>A	ENST00000273075.4	-	14	1606	c.1386C>T	c.(1384-1386)ctC>ctT	p.L462L	DNPEP_ENST00000490371.1_5'UTR|DNPEP_ENST00000523282.1_Silent_p.L470L|DNPEP_ENST00000373972.1_Silent_p.L387L	NM_012100.2	NP_036232.2	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	452					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	TGAGGGTCTGGAGGACTCCTG	0.612000													9	33					0	0	0.004482	0	0
SULF1	23213	broad.mit.edu	37	8	70550829	70550829	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:70550829T>G	ENST00000260128.4	+	20	3094	c.2377T>G	c.(2377-2379)Ttt>Gtt	p.F793V	SULF1_ENST00000402687.4_Missense_Mutation_p.F793V|SULF1_ENST00000458141.2_Missense_Mutation_p.F793V|SULF1_ENST00000419716.3_Missense_Mutation_p.F793V|SULF1_ENST00000521946.1_3'UTR	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	793					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTTCTGTGAGTTTGCTACTGG	0.363000													33	82					0	0	0.013726	0	0
TFEB	7942	broad.mit.edu	37	6	41658526	41658526	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:41658526G>A	ENST00000394283.1	-	3	1569	c.343C>T	c.(343-345)Ccg>Tcg	p.P115S	TFEB_ENST00000230323.4_Missense_Mutation_p.P115S|TFEB_ENST00000358871.2_Missense_Mutation_p.P129S|TFEB_ENST00000420312.1_Intron|TFEB_ENST00000403298.4_Missense_Mutation_p.P115S|TFEB_ENST00000373033.1_Missense_Mutation_p.P115S			P19484	TFEB_HUMAN	transcription factor EB	115				GSPKPPPAASPGVRAGHVLSSSAGNSAPN -> ALRNPHQP PPQGCELDTCCPPPLATVLPI (in Ref. 1; AAA36730).	embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	11	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GGGGGTTTCGGAGAGCCCTGG	0.632000			T	ALPHA	renal (childhood epithelioid)								7	37					0	0	0.006214	0	0
PILRB	29990	broad.mit.edu	37	7	99955856	99955856	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:99955856C>T	ENST00000448382.1	+	6	1414	c.297C>T	c.(295-297)ccC>ccT	p.P99P	PILRB_ENST00000452089.1_5'UTR|PILRB_ENST00000444874.1_5'UTR|PILRB_ENST00000444073.1_5'UTR|PILRB_ENST00000310771.4_5'UTR			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta	0	Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCAGGCAGCCCCTCCACAGGG	0.692000													21	50					0	0	0.012319	0	0
LY96	23643	broad.mit.edu	37	8	74941192	74941192	+	Splice_Site	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:74941192G>T	ENST00000284818.2	+	5	477	c.384_splice	c.e5-1	p.G129_splice	LY96_ENST00000518893.1_Splice_Site_p.G99_splice	NM_015364.4	NP_056179.3	Q9Y6Y9	LY96_HUMAN	lymphocyte antigen 96	129					cellular defense response|detection of lipopolysaccharide|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	extracellular space|lipopolysaccharide receptor complex|plasma membrane	coreceptor activity|lipopolysaccharide receptor activity|protein binding			endometrium(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5	Breast(64;0.0311)		Epithelial(68;0.0208)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0619)			TCATTTTAGGGAAAATACAAA	0.333000													15	27					2.31682e-05	2.39818e-05	0.003163	1	0
TRAV3	28690	broad.mit.edu	37	14	22192510	22192510	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:22192510G>A	ENST00000390425.2	+	0	461																											CCTTCCACCTGAAGAAACCAT	0.493000													27	32					0	0	0.021523	0	0
HELLS	3070	broad.mit.edu	37	10	96313988	96313988	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:96313988G>A	ENST00000348459.5	+	3	364	c.259G>A	c.(259-261)Gaa>Aaa	p.E87K	HELLS_ENST00000394036.1_Missense_Mutation_p.E87K|HELLS_ENST00000394044.1_Missense_Mutation_p.E87K|HELLS_ENST00000371332.4_Missense_Mutation_p.E87K|HELLS_ENST00000239026.6_Missense_Mutation_p.E87K|HELLS_ENST00000462057.1_3'UTR|HELLS_ENST00000394045.1_Missense_Mutation_p.E87K	NM_018063.3	NP_060533.2	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	87					cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		GACGAAAATGGAACAGCAACA	0.299000													24	75					0	0	0.004656	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38572802	38572802	+	Silent	SNP	C	C	T	rs141215232		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:38572802C>T	ENST00000222345.6	+	3	1106	c.597C>T	c.(595-597)ttC>ttT	p.F199F		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	199					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TGCCCCTCTTCCGCGAGTACG	0.706000													13	34					0	0	0.020292	0	0
IGSF3	3321	broad.mit.edu	37	1	117150580	117150580	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:117150580G>A	ENST00000369486.3	-	5	1971	c.1206C>T	c.(1204-1206)atC>atT	p.I402I	IGSF3_ENST00000318837.6_Silent_p.I402I|IGSF3_ENST00000369483.1_Silent_p.I402I	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	402	Ig-like C2-type 4.					integral to membrane		p.I402I(2)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GGAGGACTATGATGGGGATGT	0.502000													7	172					0	0	0.008291	0	0
NPSR1	387129	broad.mit.edu	37	7	34888189	34888189	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:34888189G>A	ENST00000360581.1	+	8	1067	c.939G>A	c.(937-939)gtG>gtA	p.V313V	NPSR1_ENST00000531252.1_Silent_p.V302V|NPSR1_ENST00000381542.1_Silent_p.V247V|NPSR1_ENST00000381539.3_Silent_p.V313V|NPSR1_ENST00000359791.1_Silent_p.V313V	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	313						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	ATGCCTCTGTGATCATTCAGA	0.502000													58	143					0	0	0.014410	0	0
BRINP1	1620	broad.mit.edu	37	9	121929907	121929907	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:121929907C>A	ENST00000265922.3	-	8	2202	c.1741G>T	c.(1741-1743)Gaa>Taa	p.E581*	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		581					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						TAGCCAAATTCCCCGAAGGGC	0.537000													25	76					4.87955e-14	5.14516e-14	0.005443	1	0
OVCH1	341350	broad.mit.edu	37	12	29617568	29617568	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:29617568G>A	ENST00000318184.5	-	18	1996	c.1997C>T	c.(1996-1998)gCc>gTc	p.A666V	OVCH1-AS1_ENST00000549411.1_Intron|OVCH1-AS1_ENST00000551108.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	666	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TTGTATTAGGGCAATGTCAGA	0.463000													10	31					0	0	0.008291	0	0
C6	729	broad.mit.edu	37	5	41181522	41181522	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:41181522C>T	ENST00000263413.3	-	7	1130	c.866G>A	c.(865-867)aGa>aAa	p.R289K	C6_ENST00000475349.1_5'UTR|C6_ENST00000337836.5_Missense_Mutation_p.R289K	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	289	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ATTTTCACTTCTCTTTGAGGA	0.363000													7	45					0	0	0.003080	0	0
EZH2	2146	broad.mit.edu	37	7	148508727	148508727	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:148508727T>A	ENST00000320356.2	-	16	2058	c.1937A>T	c.(1936-1938)tAc>tTc	p.Y646F	EZH2_ENST00000541220.1_Missense_Mutation_p.Y590F|EZH2_ENST00000350995.2_Missense_Mutation_p.Y602F|EZH2_ENST00000483967.1_Missense_Mutation_p.Y632F|EZH2_ENST00000460911.1_Missense_Mutation_p.Y641F|EZH2_ENST00000478654.1_Missense_Mutation_p.Y590F|EZH2_ENST00000476773.1_Missense_Mutation_p.Y590F	NM_001203247.1|NM_001203248.1|NM_004456.4	NP_001190176.1|NP_001190177.1|NP_004447.2	Q15910	EZH2_HUMAN	enhancer of zeste homolog 2 (Drosophila)	641	SET.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding	p.Y646F(59)|p.Y646S(22)|p.Y602F(8)|p.Y646C(6)|p.Y602S(4)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(313)|kidney(3)|large_intestine(8)|liver(1)|lung(23)|parathyroid(2)|skin(3)|upper_aerodigestive_tract(3)	359	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			CTCTCCACAGTATTCTGAGAT	0.378000			Mis		DLBCL								9	33					0	0	0.006214	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58022919	58022919	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:58022919G>A	ENST00000341156.4	-	7	1307	c.723C>T	c.(721-723)tcC>tcT	p.S241S	B4GALNT1_ENST00000449184.3_Intron|B4GALNT1_ENST00000418555.2_Silent_p.S186S	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	241					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GTCCCTCGGTGGAGAACCGGA	0.537000													8	23					0	0	0.008291	0	0
DCLK1	9201	broad.mit.edu	37	13	36700097	36700097	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:36700097G>A	ENST00000255448.4	-	2	389	c.178C>T	c.(178-180)Cgt>Tgt	p.R60C	DCLK1_ENST00000379892.4_Missense_Mutation_p.R60C|DCLK1_ENST00000360631.3_Missense_Mutation_p.R60C	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	60	Doublecortin 1.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CGATAGAAACGAACTTTCTTG	0.582000													26	41					0	0	0.004656	0	0
TMEM27	57393	broad.mit.edu	37	X	15646196	15646196	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:15646196C>T	ENST00000380342.3	-	6	822	c.567G>A	c.(565-567)atG>atA	p.M189I		NM_020665.4	NP_065716.1	Q9HBJ8	TMM27_HUMAN	transmembrane protein 27	189					proteolysis	integral to membrane	metallopeptidase activity|peptidyl-dipeptidase activity			endometrium(3)|lung(4)|ovary(1)	8	Hepatocellular(33;0.183)					CAATTGTGATCATGTTTTCAC	0.428000													10	5					0	0	0.008291	0	0
PSKH1	5681	broad.mit.edu	37	16	67943579	67943579	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:67943579C>T	ENST00000291041.5	+	2	1097	c.927C>T	c.(925-927)atC>atT	p.I309I		NM_006742.2	NP_006733.1	P11801	KPSH1_HUMAN	protein serine kinase H1	309	Protein kinase.					endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|nuclear speck|plasma membrane	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(7)|pancreas(1)	12		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0044)|Epithelial(162;0.0197)|all cancers(182;0.128)		ACCGGCAGATCCTCAGGGGCA	0.597000													5	17					0	0	0.014758	0	0
OR4D9	390199	broad.mit.edu	37	11	59283138	59283138	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:59283138C>T	ENST00000329328.3	+	1	753	c.753C>T	c.(751-753)ttC>ttT	p.F251F		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						CCCTGCATTTCGTGCCCTGCA	0.562000													66	154					0	0	0.014410	0	0
CACNA1E	777	broad.mit.edu	37	1	181767540	181767540	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:181767540C>T	ENST00000526775.1	+	46	6491	c.6326C>T	c.(6325-6327)tCc>tTc	p.S2109F	CACNA1E_ENST00000367567.4_Missense_Mutation_p.S1735F|CACNA1E_ENST00000357570.5_Missense_Mutation_p.S2122F|CACNA1E_ENST00000360108.3_Missense_Mutation_p.S2152F|CACNA1E_ENST00000358338.5_Missense_Mutation_p.S2060F|CACNA1E_ENST00000367573.2_Missense_Mutation_p.S2171F|CACNA1E_ENST00000367570.1_Missense_Mutation_p.S2128F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2171					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCCCTCCTTTCCTACAGCTCC	0.622000													28	111					0	0	0.007291	0	0
AATF	26574	broad.mit.edu	37	17	35376338	35376338	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:35376338C>T	ENST00000225402.5	+	9	1684	c.1433C>T	c.(1432-1434)tCc>tTc	p.S478F		NM_012138.3	NP_036270.1	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	478					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)	18		Breast(25;0.00607)				AAGACCAGCTCCTTGGATCCC	0.438000													35	52					0	0	0.008740	0	0
OR6C75	390323	broad.mit.edu	37	12	55759556	55759556	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:55759556G>A	ENST00000343399.3	+	1	662	c.662G>A	c.(661-663)cGg>cAg	p.R221Q		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						AACATCATCCGGACAATTCTG	0.388000													7	21					0	0	0.003080	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077861	19077861	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:19077861G>A	ENST00000329773.2	-	2	176	c.89C>T	c.(88-90)aCc>aTc	p.T30I		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	30					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						CGGGATCAGGGTCTCCTTGCC	0.562000													85	166					0	0	0.014410	0	0
FLG2	388698	broad.mit.edu	37	1	152330124	152330124	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:152330124C>T	ENST00000388718.5	-	3	211		c.e3-1		FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2								calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATCTGGGTTCTGTATATGAG	0.408000													4	32					0	0	0.009096	0	0
OR5I1	10798	broad.mit.edu	37	11	55703536	55703536	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:55703536G>A	ENST00000301532.3	-	1	340	c.341C>T	c.(340-342)tCc>tTc	p.S114F		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						CAGGATGAAGGATTCTGTATC	0.438000													4	4					0	0	0.009096	0	0
MUC16	94025	broad.mit.edu	37	19	9062259	9062259	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:9062259G>A	ENST00000397910.4	-	3	25390	c.25187C>T	c.(25186-25188)tCc>tTc	p.S8396F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8398	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCAGAAGTGGATATGGAAAC	0.483000													27	22					0	0	0.004656	0	0
DENND5A	23258	broad.mit.edu	37	11	9168652	9168652	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:9168652C>A	ENST00000328194.3	-	16	3102	c.2782G>T	c.(2782-2784)Gag>Tag	p.E928*	DENND5A_ENST00000530044.1_Nonsense_Mutation_p.E928*|DENND5A_ENST00000527700.1_Nonsense_Mutation_p.E271*	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	928	RUN 1.									breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						AGGAACTGCTCCTTCTCGTCA	0.478000													27	55					4.87955e-14	5.14516e-14	0.005443	1	0
SSPO	23145	broad.mit.edu	37	7	149511897	149511897	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:149511897C>T	ENST00000378016.2	+	0	10447							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCATGGTCTCCCTGCGACAT	0.697000													4	3					0	0	0.014758	0	0
ALMS1	7840	broad.mit.edu	37	2	73680811	73680811	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:73680811C>A	ENST00000264448.6	+	8	7265	c.7154C>A	c.(7153-7155)tCt>tAt	p.S2385Y	ALMS1_ENST00000409009.1_Missense_Mutation_p.S2343Y|ALMS1_ENST00000377715.1_Missense_Mutation_p.S2385Y	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2385					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						GCAGCCAAATCTGTAATGAGG	0.383000													8	19					5.18039e-06	5.37872e-06	0.003080	1	0
BOD1L2	284257	broad.mit.edu	37	18	54814967	54814967	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:54814967G>A	ENST00000585477.1	+	1	675	c.424G>A	c.(424-426)Gaa>Aaa	p.E142K		NM_001257964.1	NP_001244893.1			biorientation of chromosomes in cell division 1-like 2																		AATAATTCATGAATTCCTGGT	0.507000													13	19					0	0	0.016723	0	0
DNAI1	27019	broad.mit.edu	37	9	34506686	34506686	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:34506686C>T	ENST00000242317.4	+	13	1296	c.1125C>T	c.(1123-1125)ttC>ttT	p.F375F		NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	375					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		ACCCCAGCTTCCCTGAGTACA	0.587000									Kartagener syndrome				16	41					0	0	0.006122	0	0
BPIFA3	128861	broad.mit.edu	37	20	31805385	31805385	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:31805385C>T	ENST00000375454.3	+	1	253	c.43C>T	c.(43-45)Ctg>Ttg	p.L15L	BPIFA3_ENST00000490499.1_3'UTR|BPIFA3_ENST00000375452.3_Silent_p.L15L	NM_178466.3	NP_848561.2	Q9BQP9	SPLC3_HUMAN	BPI fold containing family A, member 3	15						extracellular region	lipid binding										CCTCGGGTTGCTGGCCTTGCC	0.597000													13	60					0	0	0.020292	0	0
OR4M1	441670	broad.mit.edu	37	14	20248616	20248616	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:20248616C>T	ENST00000315957.4	+	1	216	c.135C>T	c.(133-135)atC>atT	p.I45I		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATATCCTTATCATTTGCACCA	0.433000													29	134					0	0	0.008361	0	0
CHFR	55743	broad.mit.edu	37	12	133430057	133430057	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:133430057G>A	ENST00000266880.7	-	12	1431	c.1368C>T	c.(1366-1368)gcC>gcT	p.A456A	CHFR_ENST00000315585.7_Silent_p.A415A|CHFR_ENST00000537522.1_Silent_p.A78A|CHFR_ENST00000443047.2_Silent_p.A364A|CHFR_ENST00000541837.2_5'UTR|CHFR_ENST00000450056.2_Silent_p.A444A|CHFR_ENST00000432561.2_Silent_p.A456A			Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	456					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		CATCCCCCAGGGCCTGTGGGG	0.697000													3	5					0	0	0.009096	0	0
FAM154A	158297	broad.mit.edu	37	9	18928076	18928076	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:18928076G>A	ENST00000380534.4	-	4	1678	c.1399C>T	c.(1399-1401)Cag>Tag	p.Q467*	FAM154A_ENST00000380530.1_3'UTR|FAM154A_ENST00000542071.1_Nonsense_Mutation_p.Q275*	NM_153707.2	NP_714918.2	Q8IYX7	F154A_HUMAN	family with sequence similarity 154, member A	467										breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|skin(1)	26				GBM - Glioblastoma multiforme(50;6.53e-16)		AACTCCCTCTGGTTGGGGTTT	0.403000													37	107					0	0	0.007835	0	0
VPS13B	157680	broad.mit.edu	37	8	100887879	100887879	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:100887879G>A	ENST00000358544.2	+	62	12165	c.12054G>A	c.(12052-12054)agG>agA	p.R4018R	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Silent_p.R3993R	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	4018					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAGCCCTGAGGAAAGGGTTTC	0.443000													13	53					0	0	0.003163	0	0
SCTR	6344	broad.mit.edu	37	2	120206320	120206320	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:120206320G>A	ENST00000019103.5	-	10	1225	c.958C>T	c.(958-960)Ctg>Ttg	p.L320L		NM_002980.2	NP_002971.2	P47872	SCTR_HUMAN	secretin receptor	320					digestion|excretion	integral to plasma membrane	secretin receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)	19					Secretin(DB00021)	TTTCTCATCAGGATTCTTAGA	0.433000													6	19					0	0	0.001168	0	0
AATF	26574	broad.mit.edu	37	17	35376339	35376339	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:35376339C>T	ENST00000225402.5	+	9	1685	c.1434C>T	c.(1432-1434)tcC>tcT	p.S478S		NM_012138.3	NP_036270.1	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	478					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)	18		Breast(25;0.00607)				AGACCAGCTCCTTGGATCCCA	0.438000													34	53					0	0	0.007835	0	0
KCNA3	3738	broad.mit.edu	37	1	111216243	111216243	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:111216243C>T	ENST00000369769.2	-	1	1412	c.1189G>A	c.(1189-1191)Gag>Aag	p.E397K		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	397						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		AATCCCAGCTCCCGCATGGAC	0.582000													25	67					0	0	0.018920	0	0
LEPREL1	55214	broad.mit.edu	37	3	189712007	189712007	+	Silent	SNP	G	G	A	rs114077778	by1000genomes	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:189712007G>A	ENST00000319332.5	-	3	896	c.699C>T	c.(697-699)ttC>ttT	p.F233F	LEPREL1_ENST00000427335.2_Silent_p.F52F	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	233					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AGGCTTGTTCGAAGTGCCTGA	0.403000													8	31					0	0	0.004482	0	0
ZNF549	256051	broad.mit.edu	37	19	58048918	58048918	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:58048918C>T	ENST00000376233.3	+	4	727	c.546C>T	c.(544-546)ttC>ttT	p.F182F	ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron|ZNF549_ENST00000240719.3_Silent_p.F169F	NM_001199295.1	NP_001186224.1	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACAATCTTTTCCCATGCAAAG	0.483000													15	27					0	0	0.003163	0	0
NPY4R	5540	broad.mit.edu	37	10	47086923	47086923	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:47086923C>T	ENST00000374312.1	+	3	559	c.140C>T	c.(139-141)tCc>tTc	p.S47F	NPY4R_ENST00000395716.1_Missense_Mutation_p.S47F	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4									p.S47F(1)									ATCGTCACTTCCTACAGCATT	0.522000													22	231					0	0	0.014323	0	0
DPYD	1806	broad.mit.edu	37	1	97839184	97839184	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:97839184G>A	ENST00000370192.3	-	16	2091	c.1991C>T	c.(1990-1992)gCc>gTc	p.A664V		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	664	Uracil binding (Potential).				'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TAACTCCAGGGCATCTGCTCC	0.433000													7	24					0	0	0.001984	0	0
ADAM7	8756	broad.mit.edu	37	8	24304749	24304749	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:24304749C>T	ENST00000175238.6	+	3	290	c.207C>T	c.(205-207)acC>acT	p.T69T	ADAM7_ENST00000441335.2_Silent_p.T69T|RP11-624C23.1_ENST00000519689.1_RNA|ADAM7_ENST00000380789.1_Silent_p.T69T|RP11-624C23.1_ENST00000523578.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	69					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		ATAGAAAAACCTTAGTCCTTC	0.328000													15	25					0	0	0.020292	0	0
KRT32	3882	broad.mit.edu	37	17	39622158	39622158	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:39622158C>T	ENST00000225899.3	-	3	678	c.575G>A	c.(574-576)cGg>cAg	p.R192Q		NM_002278.3	NP_002269.3	Q14532	K1H2_HUMAN	keratin 32	192	Coil 1B.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(137;0.000812)				CACCAGCTGCCGCATGGCCAG	0.587000													28	80					0	0	0.007291	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37188577	37188577	+	RNA	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:37188577T>G	ENST00000425901.2	+	0	2419					NR_033753.2																						ACATATGTGATCTCTGTACCT	0.517000													5	229					0	0	0.001984	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20868168	20868168	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:20868168A>T	ENST00000381552.1	+	6	993	c.625A>T	c.(625-627)Att>Ttt	p.I209F	SLCO1C1_ENST00000266509.2_Missense_Mutation_p.I209F|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.I91F|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.I209F|SLCO1C1_ENST00000540354.1_Intron			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	209					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					GCCTTTGGGCATTGCCTACCT	0.428000													31	57					0	0	0.013726	0	0
PSMG2	56984	broad.mit.edu	37	18	12718630	12718630	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:12718630C>T	ENST00000317615.6	+	4	1085	c.403C>T	c.(403-405)Cgt>Tgt	p.R135C	RP11-973H7.2_ENST00000585331.1_RNA|PSMG2_ENST00000590217.1_Missense_Mutation_p.R135C	NM_020232.4|NM_147163.1	NP_064617.2|NP_671692.1	Q969U7	PSMG2_HUMAN	proteasome (prosome, macropain) assembly chaperone 2	135					proteasome assembly	nucleus	protein binding			lung(1)|prostate(2)|skin(1)	4						TCTGCAGCTTCGTAGGTATGT	0.368000													6	57					0	0	0.001984	0	0
GGT7	2686	broad.mit.edu	37	20	33449295	33449295	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:33449295G>A	ENST00000336431.5	-	4	672	c.628C>T	c.(628-630)Cca>Tca	p.P210S		NM_178026.2	NP_821158.2	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	210					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			NS(2)|breast(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)	20						AGGGCCCCTGGTGCGGACTCC	0.567000													20	47					0	0	0.008871	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39913839	39913839	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:39913839G>A	ENST00000425673.1	+	16	2383	c.2058G>A	c.(2056-2058)ggG>ggA	p.G686G	PLEKHG2_ENST00000409794.3_Silent_p.G715G|PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000409797.2_Intron|PLEKHG2_ENST00000458508.2_Silent_p.G656G			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	715					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TGTTTTCTGGGAGCAATCCTG	0.592000													31	79					0	0	0.009535	0	0
MCM3	4172	broad.mit.edu	37	6	52144196	52144196	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:52144196G>A	ENST00000596288.1	-	5	895	c.868C>T	c.(868-870)Cct>Tct	p.P290S	MCM3_ENST00000419835.2_Missense_Mutation_p.P199S|MCM3_ENST00000476448.1_5'UTR|MCM3_ENST00000229854.7_Missense_Mutation_p.P245S	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	245					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					TTCTTTCCAGGAAGGCAACGG	0.522000													41	54					0	0	0.006999	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21028306	21028306	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:21028306G>A	ENST00000381545.3	+	9	1084	c.865G>A	c.(865-867)Gaa>Aaa	p.E289K	SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.E289K|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.E289K|LST3_ENST00000540229.1_Missense_Mutation_p.E289K|LST3_ENST00000381541.3_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	289					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity	p.E289*(1)		breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ACCACAAAAAGAAAGAAAAAT	0.328000													7	33					0	0	0.001984	0	0
POLD2	5425	broad.mit.edu	37	7	44156480	44156480	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:44156480G>A	ENST00000406581.2	-	7	1365	c.716C>T	c.(715-717)tCc>tTc	p.S239F	POLD2_ENST00000452185.1_Missense_Mutation_p.S239F|POLD2_ENST00000223361.3_Missense_Mutation_p.S239F	NM_001256879.1	NP_001243808.1	P49005	DPOD2_HUMAN	polymerase (DNA directed), delta 2, accessory subunit	239					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	12						GATAACCCGGGAGACGTGGGC	0.657000													14	22					0	0	0.003163	0	0
OR8D2	283160	broad.mit.edu	37	11	124189248	124189248	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:124189248G>A	ENST00000357438.2	-	1	936	c.846C>T	c.(844-846)atC>atT	p.I282I		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TCAGCATGGGGATTATTGTGA	0.423000													9	15					0	0	0.008291	0	0
CDS1	1040	broad.mit.edu	37	4	85569815	85569815	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:85569815C>T	ENST00000295887.5	+	13	1785	c.1362C>T	c.(1360-1362)atC>atT	p.I454I		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	454				TLKTHLIEKGILQPTLKV -> P (in Ref. 1; AAC50735).	signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		AGAAAGGAATCCTACAACCCA	0.388000													4	21					0	0	0.009096	0	0
SLC12A5	57468	broad.mit.edu	37	20	44664159	44664159	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:44664159A>G	ENST00000454036.1	+	3	409	c.333A>G	c.(331-333)aaA>aaG	p.K111K	SLC12A5_ENST00000372315.1_Silent_p.K88K|SLC12A5_ENST00000539566.1_Silent_p.K88K|SLC12A5_ENST00000243964.3_Silent_p.K88K	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	111					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGGGTGGAAAAAAGAAGCCGG	0.562000													14	46					0	0	0.016723	0	0
ST18	9705	broad.mit.edu	37	8	53084745	53084745	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:53084745G>A	ENST00000276480.7	-	10	1359	c.676C>T	c.(676-678)Cat>Tat	p.H226Y		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	226						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCTTTTTTATGATCTGTTAAA	0.393000													22	37					0	0	0.012319	0	0
HRASLS5	117245	broad.mit.edu	37	11	63233660	63233660	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:63233660G>A	ENST00000540857.1	-	5	771	c.639C>T	c.(637-639)atC>atT	p.I213I	HRASLS5_ENST00000539221.1_Silent_p.I223I|HRASLS5_ENST00000301790.4_Silent_p.I223I	NM_001146728.1|NM_001146729.1|NM_054108.3	NP_001140200.1|NP_001140201.1|NP_473449.1	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5	223										endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	14						TGTACTGCACGATCTTGTTGA	0.517000													19	54					0	0	0.010504	0	0
TPX2	22974	broad.mit.edu	37	20	30381722	30381722	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:30381722C>T	ENST00000340513.4	+	15	2217	c.1689C>T	c.(1687-1689)atC>atT	p.I563I	TPX2_ENST00000300403.6_Silent_p.I527I			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	527					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			AGCCCCAAATCCCAGAGGCAA	0.418000													46	128					0	0	0.014410	0	0
GRM2	2912	broad.mit.edu	37	3	51743182	51743182	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:51743182C>T	ENST00000395052.3	+	2	417	c.183C>T	c.(181-183)cgC>cgT	p.R61R	GRM2_ENST00000442933.2_Silent_p.R61R|GRM2_ENST00000475478.1_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	61					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCATCCAGCGCCTGGAGGCCA	0.637000													30	68					0	0	0.008361	0	0
PRDM1	639	broad.mit.edu	37	6	106547271	106547271	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:106547271G>A	ENST00000369096.4	+	4	742	c.508G>A	c.(508-510)Gag>Aag	p.E170K	PRDM1_ENST00000369091.2_Missense_Mutation_p.E134K|PRDM1_ENST00000369089.3_Missense_Mutation_p.E36K	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	170	SET.				negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		CTCTCCCCGGGAGCAAAACCT	0.498000			"""D, N, Mis, F, S"""		DLBCL								16	27					0	0	0.004007	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130342957	130342957	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:130342957C>T	ENST00000299164.2	+	8	2094	c.2094C>T	c.(2092-2094)ttC>ttT	p.F698F		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	698	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GCTACAATTTCGTGGTGGCCA	0.582000													25	44					0	0	0.005443	0	0
POLD3	10714	broad.mit.edu	37	11	74329644	74329644	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:74329644C>T	ENST00000263681.2	+	6	584	c.455C>T	c.(454-456)tCc>tTc	p.S152F	POLD3_ENST00000527458.1_Missense_Mutation_p.S113F|POLD3_ENST00000532497.1_Missense_Mutation_p.S46F	NM_006591.2	NP_006582.1	Q15054	DPOD3_HUMAN	polymerase (DNA-directed), delta 3, accessory subunit	152					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|stomach(1)	18	Breast(11;3.21e-06)					TCTTCGTCTTCCAAAAAGTTT	0.463000													29	75					0	0	0.007291	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136877	40136877	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:40136877C>T	ENST00000278198.2	-	2	2929	c.966G>A	c.(964-966)tcG>tcA	p.S322S	LRRC4C_ENST00000528697.1_Silent_p.S322S|LRRC4C_ENST00000527150.1_Silent_p.S322S|LRRC4C_ENST00000530763.1_Silent_p.S322S			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	322	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding	p.S322S(1)		NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				AAGCTGTGTTCGAGGGGGCCA	0.493000													10	25					0	0	0.006214	0	0
PLCH2	9651	broad.mit.edu	37	1	2418730	2418730	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:2418730C>T	ENST00000449969.1	+	7	1109	c.948C>T	c.(946-948)acC>acT	p.T316T	PLCH2_ENST00000378486.3_Silent_p.T343T|PLCH2_ENST00000378488.3_Silent_p.T343T|PLCH2_ENST00000419816.2_Silent_p.T343T|PLCH2_ENST00000288766.5_Intron|PLCH2_ENST00000378483.2_Intron			O75038	PLCH2_HUMAN	phospholipase C, eta 2	343					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CCCACAACACCTACCTCGTGG	0.612000													8	16					0	0	0.008291	0	0
IGDCC4	57722	broad.mit.edu	37	15	65676527	65676527	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:65676527G>A	ENST00000352385.2	-	20	3782	c.3573C>T	c.(3571-3573)gcC>gcT	p.A1191A	IGDCC4_ENST00000558048.1_5'UTR	NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1191						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						CTGGCCCGGGGGCTGCCAGCT	0.667000													10	23					0	0	0.006214	0	0
CCM2	83605	broad.mit.edu	37	7	45104202	45104202	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:45104202C>T	ENST00000475551.1	+	4	1171	c.411C>T	c.(409-411)tcC>tcT	p.S137S	CCM2_ENST00000258781.6_Silent_p.S143S|CCM2_ENST00000544363.1_Silent_p.S143S|CCM2_ENST00000474617.1_Silent_p.S137S|CCM2_ENST00000541586.1_Silent_p.S85S|CCM2_ENST00000381112.3_Silent_p.S164S|CCM2_ENST00000461377.1_3'UTR			Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2	143	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding			NS(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						CCGCCGTCTCCTATGTTCGGG	0.572000													8	30					0	0	0.006214	0	0
FAT2	2196	broad.mit.edu	37	5	150947511	150947511	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:150947511C>T	ENST00000261800.5	-	1	994	c.982G>A	c.(982-984)Ggg>Agg	p.G328R		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	328					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGTTGAACCCATGAAGGTAC	0.502000													85	129					0	0	0.014410	0	0
SMU1	55234	broad.mit.edu	37	9	33056197	33056197	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:33056197G>A	ENST00000397149.3	-	9	1086	c.1036C>T	c.(1036-1038)Cgt>Tgt	p.R346C	SMU1_ENST00000536631.1_Missense_Mutation_p.R185C	NM_018225.2	NP_060695.2	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	346						cytoplasm|nucleus				endometrium(2)|lung(4)|ovary(2)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		GAATGGCCACGAAATTCCTTC	0.338000													10	20					0	0	0.008291	0	0
H6PD	9563	broad.mit.edu	37	1	9324817	9324817	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:9324817C>T	ENST00000377403.2	+	5	2567	c.2265C>T	c.(2263-2265)acC>acT	p.T755T	H6PD_ENST00000602477.1_Silent_p.T766T	NM_004285.3	NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	755	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	GTGAGATCACCACGCTGGTGA	0.642000													8	30					0	0	0.010729	0	0
STPG2	285555	broad.mit.edu	37	4	98865158	98865158	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:98865158C>T	ENST00000295268.3	-	8	1023	c.933_splice	c.e8-1	p.E312_splice		NM_174952.2	NP_777612.1			sperm-tail PG-rich repeat containing 2																		TGCCAAAATTCCTGTTGAAAG	0.323000													8	35					0	0	0.004482	0	0
KCNH4	23415	broad.mit.edu	37	17	40328259	40328259	+	Silent	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:40328259C>A	ENST00000264661.3	-	5	974	c.642G>T	c.(640-642)ggG>ggT	p.G214G	KCNH4_ENST00000607371.1_Silent_p.G214G	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	214					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGCAGCGAGACCCCCCCACGG	0.607000													30	153					1.74807e-11	1.83893e-11	0.010818	1	0
SLC27A5	10998	broad.mit.edu	37	19	59022257	59022257	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:59022257C>T	ENST00000263093.2	-	2	838	c.729G>A	c.(727-729)caG>caA	p.Q243Q	SLC27A5_ENST00000601355.1_Silent_p.Q159Q	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	243					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		TGTTCTCAGCCTGCAGCTTGG	0.637000													21	41					0	0	0.010504	0	0
KMT2D	8085	broad.mit.edu	37	12	49444009	49444009	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:49444009T>G	ENST00000301067.7	-	11	3361	c.3362A>C	c.(3361-3363)gAc>gCc	p.D1121A		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		AGGGGCTGTGTCTTCCCCTAG	0.632000													5	17					0	0	0.014758	0	0
CCDC38	120935	broad.mit.edu	37	12	96266060	96266060	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:96266060C>T	ENST00000344280.3	-	14	2014	c.1457G>A	c.(1456-1458)aGg>aAg	p.R486K	SNRPF_ENST00000552085.1_Intron|SNRPF_ENST00000553192.1_Intron	NM_182496.2	NP_872302.2	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	486										breast(1)|endometrium(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CTGTTTCATCCTCTCAATTGC	0.408000													41	134					0	0	0.014410	0	0
CFB	629	broad.mit.edu	37	6	31914340	31914340	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:31914340G>A	ENST00000456570.1	+	14	1816	c.1761G>A	c.(1759-1761)ctG>ctA	p.L587L	CFB_ENST00000556679.1_Silent_p.L587L|CFB_ENST00000477310.1_Intron|CFB_ENST00000425368.2_Silent_p.L85L			P00751	CFAB_HUMAN	complement factor B	85	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						GGAGCACCCTGAAGACTCAAG	0.582000													87	345					0	0	0.014410	0	0
C1orf87	127795	broad.mit.edu	37	1	60466815	60466815	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:60466815C>G	ENST00000371201.3	-	10	1313	c.1206G>C	c.(1204-1206)aaG>aaC	p.K402N	C1orf87_ENST00000450089.2_Missense_Mutation_p.K173N|C1orf87_ENST00000486478.1_5'UTR|C1orf87_ENST00000395552.1_Missense_Mutation_p.K36N	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	402							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						CAGGGGCTTTCTTTTCATTCT	0.428000													3	7					0	0	0.004672	0	0
MSH6	2956	broad.mit.edu	37	2	48027726	48027726	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:48027726G>T	ENST00000234420.4	+	4	2756	c.2604G>T	c.(2602-2604)atG>atT	p.M868I	MSH6_ENST00000540021.1_Missense_Mutation_p.M738I|MSH6_ENST00000538136.1_Missense_Mutation_p.M566I|FBXO11_ENST00000405808.1_Intron	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	868					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TCAAAGTAATGTGTAAAATTA	0.373000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				13	30					4.36969e-10	4.5826e-10	0.016723	1	0
OR5B3	441608	broad.mit.edu	37	11	58170217	58170217	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:58170217G>A	ENST00000309403.2	-	1	665	c.666C>T	c.(664-666)acC>acT	p.T222T		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TCTTTAGGATGGTGATAAAAA	0.383000													5	7					0	0	0.014758	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138429869	138429869	+	Splice_Site	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:138429869T>A	ENST00000310018.2	-	14	1759	c.1478_splice	c.e14+1	p.N493_splice	ATP6V0A4_ENST00000393054.1_Splice_Site_p.N493_splice|ATP6V0A4_ENST00000353492.4_Splice_Site_p.N493_splice	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	493					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						TCAACTCACTTCCATGTGCCG	0.498000													44	53					0	0	0.014410	0	0
PAIP1	10605	broad.mit.edu	37	5	43536967	43536967	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:43536967G>A	ENST00000306846.3	-	6	1158	c.926C>T	c.(925-927)tCt>tTt	p.S309F	PAIP1_ENST00000514514.1_Missense_Mutation_p.S230F|PAIP1_ENST00000436644.2_Missense_Mutation_p.S230F|PAIP1_ENST00000338972.4_Missense_Mutation_p.S197F	NM_006451.4|NM_182789.3	NP_006442.2|NP_877590.1	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	309	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Lung NSC(6;2.07e-05)					CATAGGATTAGAAAACAGGGC	0.323000													10	49					0	0	0.008291	0	0
E4F1	1877	broad.mit.edu	37	16	2284180	2284180	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:2284180C>T	ENST00000301727.4	+	10	1432	c.1384C>T	c.(1384-1386)Ccg>Tcg	p.P462S	E4F1_ENST00000565090.1_Intron|E4F1_ENST00000564139.1_Missense_Mutation_p.P462S	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	462	Interaction with BMI1.|Mediates interaction with CDKN2A.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						AGGGCCGAGGCCGTTCGCCTG	0.701000													12	25					0	0	0.013537	0	0
TRIM23	373	broad.mit.edu	37	5	64906724	64906724	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:64906724G>A	ENST00000231524.9	-	5	1163	c.792C>T	c.(790-792)atC>atT	p.I264I	TRIM23_ENST00000274327.7_Silent_p.I264I|TRIM23_ENST00000381018.3_Silent_p.I264I	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	264					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		CATCTTCCACGATTTGTTCTC	0.363000													20	25					0	0	0.018920	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617118	77617118	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:77617118C>T	ENST00000521891.2	+	2	1243	c.795C>T	c.(793-795)ttC>ttT	p.F265F	ZFHX4_ENST00000518282.1_Silent_p.F265F|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Silent_p.F265F|ZFHX4_ENST00000455469.2_Silent_p.F265F	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	265						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGTCCAAATTCGATGGTTGTG	0.423000										HNSCC(33;0.089)			36	52					0	0	0.013726	0	0
PRB3	5544	broad.mit.edu	37	12	11421008	11421008	+	RNA	SNP	C	C	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:11421008C>G	ENST00000381842.3	-	0	212				PRB3_ENST00000440870.3_RNA|PRB3_ENST00000538488.1_RNA|PRB3_ENST00000279573.6_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGGGGTCGTCCTTCTGGCTTT	0.617000													13	222					0	0	0.004007	0	0
NUP160	23279	broad.mit.edu	37	11	47837085	47837085	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:47837085G>A	ENST00000378460.2	-	13	1678	c.1632C>T	c.(1630-1632)caC>caT	p.H544H	NUP160_ENST00000531016.1_5'UTR|NUP160_ENST00000530326.1_Silent_p.H430H|NUP160_ENST00000528501.1_Silent_p.H108H|NUP160_ENST00000528071.1_Silent_p.H430H	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	544					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						GGGCAAGAGGGTGAGAGAGGG	0.428000													30	77					0	0	0.013726	0	0
TDRD9	122402	broad.mit.edu	37	14	104460697	104460697	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:104460697A>G	ENST00000409874.4	+	10	1257	c.1209A>G	c.(1207-1209)gaA>gaG	p.E403E	TDRD9_ENST00000339063.5_Silent_p.E403E	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	403	Helicase C-terminal.				cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				ATATGCATGAACTTCTCACAA	0.333000													43	156					0	0	0.014410	0	0
HFM1	164045	broad.mit.edu	37	1	91850744	91850744	+	Splice_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:91850744G>A	ENST00000370425.3	-	6	900	c.802_splice	c.e6+1	p.P268_splice	HFM1_ENST00000370424.3_Intron|HFM1_ENST00000294696.5_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	268							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TAAAGGATACGAATTTCTGTG	0.249000													5	5					0	0	0.003080	0	0
ZNF532	55205	broad.mit.edu	37	18	56586876	56586876	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:56586876C>T	ENST00000336078.4	+	4	2133	c.1357C>T	c.(1357-1359)Ctc>Ttc	p.L453F	ZNF532_ENST00000589288.1_Missense_Mutation_p.L453F|ZNF532_ENST00000591808.1_Missense_Mutation_p.L453F|ZNF532_ENST00000591230.1_Missense_Mutation_p.L453F|ZNF532_ENST00000591083.1_Missense_Mutation_p.L453F	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	453					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						TACTGCTTTCCTCCCAGTGTC	0.557000													9	45					0	0	0.008291	0	0
CXCL8	3576	broad.mit.edu	37	4	74607292	74607292	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:74607292G>A	ENST00000307407.3	+	2	251	c.98G>A	c.(97-99)aGa>aAa	p.R33K	IL8_ENST00000401931.1_Missense_Mutation_p.R33K	NM_000584.3	NP_000575.1	P10145	IL8_HUMAN	interleukin 8	33					angiogenesis|calcium-mediated signaling|cell cycle arrest|cellular response to lipopolysaccharide|embryonic digestive tract development|G-protein coupled receptor protein signaling pathway|immune response|induction of positive chemotaxis|inflammatory response|negative regulation of cell proliferation|neutrophil activation|neutrophil chemotaxis|positive regulation of neutrophil chemotaxis|regulation of cell adhesion|regulation of retroviral genome replication	extracellular space|intracellular	chemokine activity|interleukin-8 receptor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(2)|urinary_tract(1)	6	Breast(15;0.00102)		all cancers(17;0.00169)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)	LUSC - Lung squamous cell carcinoma(721;0.008)	Ketoprofen(DB01009)|Salbutamol(DB01001)|Simvastatin(DB00641)|Zileuton(DB00744)	AAAGAACTTAGATGTCAGTGC	0.428000													4	16					0	0	0.009096	0	0
KIF1B	23095	broad.mit.edu	37	1	10434391	10434391	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:10434391C>T	ENST00000377086.1	+	46	5166	c.4964C>T	c.(4963-4965)tCc>tTc	p.S1655F	KIF1B_ENST00000377081.1_Missense_Mutation_p.S1655F|KIF1B_ENST00000263934.6_Missense_Mutation_p.S1609F			O60333	KIF1B_HUMAN	kinesin family member 1B	1655					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GAAGCCAATTCCCGGGCCTCT	0.433000													67	237					0	0	0.014410	0	0
EML1	2009	broad.mit.edu	37	14	100374016	100374016	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:100374016C>T	ENST00000262233.6	+	10	1189	c.1050C>T	c.(1048-1050)gaC>gaT	p.D350D	EML1_ENST00000327921.9_Silent_p.D338D|EML1_ENST00000334192.4_Silent_p.D369D	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	350						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				ACTCCAACGACCATGTGCTCT	0.423000													22	55					0	0	0.006320	0	0
CLEC5A	23601	broad.mit.edu	37	7	141629928	141629928	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:141629928C>T	ENST00000546910.1	-	7	739	c.543G>A	c.(541-543)agG>agA	p.R181R	MGAM_ENST00000497554.1_Intron|CLEC5A_ENST00000551012.2_Silent_p.R158R|CLEC5A_ENST00000439991.1_Silent_p.R77R	NM_013252.2	NP_037384.1	Q9NY25	CLC5A_HUMAN	C-type lectin domain family 5, member A	181	C-type lectin.				anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity			endometrium(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	10	Melanoma(164;0.0171)					TCTCACAGATCCTGCGGTAGC	0.413000													9	34					0	0	0.006214	0	0
IQCJ	654502	broad.mit.edu	37	3	158983184	158983184	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:158983184C>T	ENST00000482126.1	+	4	496	c.391C>T	c.(391-393)Ctc>Ttc	p.L131F	IQCJ_ENST00000451172.1_Missense_Mutation_p.L158F|IQCJ-SCHIP1_ENST00000476809.1_Intron|IQCJ-SCHIP1_ENST00000467442.1_Intron|IQCJ-SCHIP1_ENST00000485419.1_Intron	NM_001197100.1	NP_001184029.1			IQ motif containing J											cervix(1)|endometrium(2)|large_intestine(2)|lung(10)	15			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			TTTTCTCACCCTCCAGTGAAT	0.473000													5	23					0	0	0.014758	0	0
FER1L6	654463	broad.mit.edu	37	8	124978497	124978497	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:124978497G>A	ENST00000522917.1	+	5	557	c.351G>A	c.(349-351)gtG>gtA	p.V117V	FER1L6_ENST00000399018.1_Silent_p.V117V	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	117	C2 1.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAAGCACAGTGAAGGAAGGAA	0.478000													23	35					0	0	0.021523	0	0
CTSL3P	392360	broad.mit.edu	37	9	90401769	90401769	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:90401769G>A	ENST00000354530.2	+	0	627					NR_027917.1																						ATGACATGAGGAATCATCTGG	0.493000													8	24					0	0	0.006214	0	0
CYP4B1	1580	broad.mit.edu	37	1	47264785	47264785	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:47264785C>T	ENST00000271153.4	+	1	68	c.32C>T	c.(31-33)tCc>tTc	p.S11F	CYP4B1_ENST00000371923.4_Missense_Mutation_p.S11F|CYP4B1_ENST00000371919.4_Missense_Mutation_p.S11F|CYP4B1_ENST00000546128.1_Intron			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	11					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					CTGAGCTTCTCCTCCTTGGGC	0.567000													6	11					0	0	0.001168	0	0
EIF4G2	1982	broad.mit.edu	37	11	10820827	10820827	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:10820827G>A	ENST00000526148.1	-	20	2979	c.2469C>T	c.(2467-2469)caC>caT	p.H823H	EIF4G2_ENST00000525681.1_Silent_p.H823H|RP11-685M7.5_ENST00000532365.1_RNA|EIF4G2_ENST00000339995.5_Silent_p.H823H|EIF4G2_ENST00000396525.2_Silent_p.H785H	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	823	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GTAGATCAACGTGATCATGAA	0.433000													9	46					0	0	0.008291	0	0
CLVS2	134829	broad.mit.edu	37	6	123377146	123377146	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:123377146G>A	ENST00000275162.4	+	5	2206	c.871G>A	c.(871-873)Gaa>Aaa	p.E291K	CLVS2_ENST00000368438.1_Missense_Mutation_p.E145K	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	291					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						AGTAGAGAAGGAACTCTCCCC	0.522000													3	7					0	0	0.009096	0	0
CORO1C	23603	broad.mit.edu	37	12	109046188	109046188	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:109046188G>A	ENST00000261401.3	-	8	1033	c.861C>T	c.(859-861)gaC>gaT	p.D287D	CORO1C_ENST00000421578.2_Silent_p.D182D|CORO1C_ENST00000420959.2_Silent_p.D340D|CORO1C_ENST00000549772.1_Silent_p.D293D|CORO1C_ENST00000549384.1_Intron|CORO1C_ENST00000541050.1_Silent_p.D287D	NM_001105237.2|NM_001276471.1|NM_014325.2	NP_001098707.1|NP_001263400.1|NP_055140.1	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C	287					actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|skin(4)	24						GAATACTGCTGTCACCCTGTA	0.478000													33	71					0	0	0.009718	0	0
FSCN3	29999	broad.mit.edu	37	7	127238524	127238524	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:127238524C>T	ENST00000265825.5	+	4	1215	c.996C>T	c.(994-996)ccC>ccT	p.P332P	FSCN3_ENST00000420086.2_Silent_p.P198P	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	332						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						ATGGGCACCCCCTGGAGTCTG	0.557000													44	86					0	0	0.011902	0	0
XIST	7503	broad.mit.edu	37	X	73062381	73062381	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:73062381C>T	ENST00000429829.1	-	0	10207					NR_001564.2																						GCCTGCTTTTCATAGTCAACA	0.393000													8	7					0	0	0.003080	0	0
BCL9	607	broad.mit.edu	37	1	147090901	147090901	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:147090901G>A	ENST00000234739.3	+	8	1680	c.940G>A	c.(940-942)Gtg>Atg	p.V314M		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	314	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					CAATAGGGCAGTGACCCCTGT	0.582000			T	"""IGH@, IGL@"""	B-ALL								19	106					0	0	0.008871	0	0
DNAH1	25981	broad.mit.edu	37	3	52422243	52422243	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:52422243C>T	ENST00000420323.2	+	57	9325	c.9064C>T	c.(9064-9066)Cag>Tag	p.Q3022*		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3022	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGAAGAGTTCCAGCCAGCCAC	0.567000													3	16					0	0	0.009096	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50418224	50418224	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:50418224C>T	ENST00000435965.1	-	8	970	c.797G>A	c.(796-798)cGa>cAa	p.R266Q	CACNA2D2_ENST00000479441.1_Missense_Mutation_p.R266Q|CACNA2D2_ENST00000429770.1_Missense_Mutation_p.R266Q|CACNA2D2_ENST00000424201.2_Missense_Mutation_p.R266Q|CACNA2D2_ENST00000423994.2_Missense_Mutation_p.R266Q|CACNA2D2_ENST00000395083.1_Missense_Mutation_p.R266Q|CACNA2D2_ENST00000360963.3_Missense_Mutation_p.R197Q|CACNA2D2_ENST00000266039.3_Missense_Mutation_p.R266Q			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	266					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	CTTGGGGGCTCGCCACGGGGT	0.647000													3	5					0	0	0.009096	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48918327	48918327	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:48918327G>A	ENST00000311378.4	+	2	2206	c.1678G>A	c.(1678-1680)Gtc>Atc	p.V560I	WFIKKN2_ENST00000426127.1_Missense_Mutation_p.V467I|RP11-506D12.5_ENST00000572491.2_RNA	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	560	NTR.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GCTTCGTGAGGTCATGCACAA	0.627000													37	56					0	0	0.013114	0	0
SRF	6722	broad.mit.edu	37	6	43146124	43146124	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:43146124C>T	ENST00000265354.4	+	5	1613	c.1255C>T	c.(1255-1257)Ccc>Tcc	p.P419S	SRF_ENST00000457278.2_Missense_Mutation_p.P215S	NM_003131.2	NP_003122.1	P11831	SRF_HUMAN	serum response factor (c-fos serum response element-binding transcription factor)	419					angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|transcription from RNA polymerase II promoter|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	12			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GATGTATGCCCCCACCTCGGG	0.627000													14	71					0	0	0.003163	0	0
OR13J1	392309	broad.mit.edu	37	9	35869662	35869662	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:35869662G>A	ENST00000377981.2	-	1	799	c.737C>T	c.(736-738)gCt>gTt	p.A246V		NM_001004487.1	NP_001004487.1	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J, member 1	246					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			CAGCACTACAGCCAGGTGTGC	0.552000													12	37					0	0	0.010729	0	0
AKR1E2	83592	broad.mit.edu	37	10	4879766	4879766	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:4879766C>T	ENST00000298375.7	+	5	646	c.575C>T	c.(574-576)aCc>aTc	p.T192I	AKR1E2_ENST00000345253.5_Intron|AKR1E2_ENST00000525281.1_3'UTR|AKR1E2_ENST00000334019.4_Missense_Mutation_p.T192I|AKR1E2_ENST00000532248.1_Missense_Mutation_p.T192I	NM_001040177.1	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	192						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						AAGCCACTAACCAACCAGGTA	0.522000													7	31					0	0	0.001984	0	0
B3GALT1	8708	broad.mit.edu	37	2	168726477	168726477	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:168726477G>A	ENST00000305861.1	+	2	1279	c.928G>A	c.(928-930)Gaa>Aaa	p.E310K	B3GALT1_ENST00000392690.2_Missense_Mutation_p.E310K|AC016723.4_ENST00000436982.2_RNA	NM_020981.3	NP_066191.1	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	310					lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18						CTCTCCAGAAGAAATGCACAG	0.378000													6	36					0	0	0.001168	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870935	51870935	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:51870935C>T	ENST00000371497.5	+	2	1825	c.938C>T	c.(937-939)tCc>tTc	p.S313F	TSHZ2_ENST00000329613.6_Missense_Mutation_p.S310F|TSHZ2_ENST00000603338.2_Missense_Mutation_p.S310F	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	313					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CCAACCATTTCCTCGAAAATG	0.453000													24	71					0	0	0.005443	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136712	40136712	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:40136712G>A	ENST00000278198.2	-	2	3094	c.1131C>T	c.(1129-1131)gcC>gcT	p.A377A	LRRC4C_ENST00000528697.1_Silent_p.A377A|LRRC4C_ENST00000527150.1_Silent_p.A377A|LRRC4C_ENST00000530763.1_Silent_p.A377A			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	377	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GGGATGTGGAGGCCCGACATT	0.512000													26	45					0	0	0.021523	0	0
ZFAT	57623	broad.mit.edu	37	8	135614003	135614003	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:135614003G>A	ENST00000520727.1	-	7	2222	c.1923C>T	c.(1921-1923)ccC>ccT	p.P641P	ZFAT_ENST00000523399.1_Silent_p.P591P|ZFAT_ENST00000377838.3_Silent_p.P653P|ZFAT_ENST00000520214.1_Silent_p.P641P|ZFAT_ENST00000520356.1_Silent_p.P641P|ZFAT_ENST00000429442.2_Silent_p.P641P	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	653					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTTCCCCTAGGGGGCTCTGGG	0.592000													47	62					0	0	0.014410	0	0
HK3	3101	broad.mit.edu	37	5	176314516	176314516	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:176314516G>A	ENST00000292432.5	-	11	1627	c.1536C>T	c.(1534-1536)ctC>ctT	p.L512L		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	512	Catalytic.			LR -> SE (in Ref. 4; AAC50422).	glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTCCCCTCGGAGCCCCTTGG	0.657000													15	46					0	0	0.020292	0	0
CIAO1	9391	broad.mit.edu	37	2	96934294	96934294	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:96934294G>C	ENST00000488633.1	+	5	808	c.589G>C	c.(589-591)Gtg>Ctg	p.V197L		NM_004804.2	NP_004795.1	O76071	CIAO1_HUMAN	cytosolic iron-sulfur protein assembly 1	197					chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding			endometrium(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	5						TGAATCCACTGTGTGGAGCTT	0.552000													15	42					0	0	0.003163	0	0
MASP2	10747	broad.mit.edu	37	1	11090804	11090804	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:11090804C>T	ENST00000400897.3	-	9	1238		c.e9+1			NM_006610.3	NP_006601.2	O00187	MASP2_HUMAN	mannan-binding lectin serine peptidase 2						complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			biliary_tract(1)|endometrium(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		AATTTGCATACCATCATTCAC	0.448000													5	30					0	0	0.001984	0	0
IGHG2	3501	broad.mit.edu	37	14	106110952	106110952	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:106110952G>A	ENST00000390545.2	-	0	175																											GAGTCCTGAGGACTGTAGGAC	0.622000													18	40					0	0	0.006122	0	0
KRTAP4-5	85289	broad.mit.edu	37	17	39305976	39305976	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:39305976C>T	ENST00000343246.4	-	1	78	c.44G>A	c.(43-45)tGt>tAt	p.C15Y		NM_033188.3	NP_149445.3	Q9BYR2	KRA45_HUMAN	keratin associated protein 4-5	15	27 X 5 AA repeats of C-C-[GRQVCHIEK]- [SPTR]-[VSTQYC].					keratin filament				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CTCCAGGCCACAGCTCTGCTC	0.602000													16	42					0	0	0.007413	0	0
SAMD3	154075	broad.mit.edu	37	6	130505278	130505278	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:130505278G>A	ENST00000532763.1	-	6	747	c.618C>T	c.(616-618)caC>caT	p.H206H	SAMD3_ENST00000324172.6_Silent_p.H208H|SAMD3_ENST00000533296.1_5'UTR|SAMD3_ENST00000368134.2_Silent_p.H208H|SAMD3_ENST00000439090.2_Silent_p.H208H|SAMD3_ENST00000437477.2_Silent_p.H208H|SAMD3_ENST00000457563.2_Silent_p.H232H			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	208										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CCAGGAAAGGGTGGGCCTGCA	0.483000													13	29					0	0	0.004007	0	0
TRIM58	25893	broad.mit.edu	37	1	248039784	248039784	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:248039784A>T	ENST00000366481.3	+	6	1502	c.1454A>T	c.(1453-1455)cAt>cTt	p.H485L	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	485						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGAGATGATCATCTCTAAAAT	0.438000													9	38					0	0	0.004482	0	0
ZNF518A	9849	broad.mit.edu	37	10	97919527	97919527	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:97919527C>T	ENST00000534948.1	+	0	4305							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AATTTTTAACCCTGTTTTAAA	0.358000													13	56					0	0	0.016723	0	0
DSG3	1830	broad.mit.edu	37	18	29049074	29049074	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:29049074C>T	ENST00000257189.4	+	12	1742	c.1659C>T	c.(1657-1659)gcC>gcT	p.A553A		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	553					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TCCTCAGAGCCCAGGAACAGA	0.463000													45	109					0	0	0.014410	0	0
LOC440040	440040	broad.mit.edu	37	11	49598415	49598415	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:49598415G>A	ENST00000527477.1	+	0	1019																											TGGACATAGTGAAGAGGTACA	0.428000													9	20					0	0	0.006214	0	0
CDK11B	984	broad.mit.edu	37	1	1573193	1573193	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:1573193G>A	ENST00000407249.3	-	14	1403	c.1404C>T	c.(1402-1404)ttC>ttT	p.F468F	CDK11B_ENST00000340677.5_Silent_p.F455F|CDK11B_ENST00000341832.6_Silent_p.F421F|CDK11B_ENST00000317673.7_Silent_p.F466F			P21127	CD11B_HUMAN	cyclin-dependent kinase 11B	478	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			endometrium(2)|large_intestine(3)|lung(4)|skin(1)|stomach(2)	12						ACGTGATCGGGAAGCCCTCCT	0.557000													57	127					0	0	0.014410	0	0
FNDC9	408263	broad.mit.edu	37	5	156770374	156770374	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:156770374C>T	ENST00000312349.4	-	2	358	c.171G>A	c.(169-171)acG>acA	p.T57T	CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000435847.2_Intron|CYFIP2_ENST00000318218.6_Intron|CYFIP2_ENST00000347377.6_Intron|CYFIP2_ENST00000541131.1_Intron|CYFIP2_ENST00000377576.3_Intron|CYFIP2_ENST00000442283.2_Intron|CYFIP2_ENST00000521420.1_Intron	NM_001001343.3	NP_001001343.2	Q8TBE3	FNDC9_HUMAN	fibronectin type III domain containing 9	57	Fibronectin type-III.					integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	9						CGGAGCTGATCGTTCGAGGCA	0.522000													69	87					0	0	0.014410	0	0
CTNNA3	29119	broad.mit.edu	37	10	68979533	68979533	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:68979533A>G	ENST00000433211.1	-	6	849	c.675T>C	c.(673-675)tgT>tgC	p.C225C	CTNNA3_ENST00000545309.1_Silent_p.C225C|CTNNA3_ENST00000373744.4_Silent_p.C225C	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	225					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						AATGCTCCAAACAAGCTGAAC	0.423000													17	31					0	0	0.008871	0	0
TMC2	117532	broad.mit.edu	37	20	2604977	2604977	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:2604977C>T	ENST00000358864.1	+	17	2256	c.2241C>T	c.(2239-2241)ttC>ttT	p.F747F		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	747						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TCCCAACCTTCCTGGGCAAGA	0.498000													28	61					0	0	0.005443	0	0
CD22	933	broad.mit.edu	37	19	35827096	35827096	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:35827096G>A	ENST00000085219.5	+	4	636	c.570G>A	c.(568-570)tcG>tcA	p.S190S	CD22_ENST00000594250.1_Silent_p.S190S|CD22_ENST00000536635.2_Silent_p.S190S|CD22_ENST00000341773.6_Silent_p.S190S|CD22_ENST00000419549.2_Silent_p.S18S|CD22_ENST00000270311.6_Silent_p.S70S|CD22_ENST00000544992.2_Silent_p.S190S	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	190	Ig-like C2-type 1.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CTGTCACCTCGACCTCCTTGA	0.547000													25	60					0	0	0.004656	0	0
TFEB	7942	broad.mit.edu	37	6	41658525	41658525	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:41658525G>A	ENST00000394283.1	-	3	1570	c.344C>T	c.(343-345)cCg>cTg	p.P115L	TFEB_ENST00000230323.4_Missense_Mutation_p.P115L|TFEB_ENST00000358871.2_Missense_Mutation_p.P129L|TFEB_ENST00000420312.1_Intron|TFEB_ENST00000403298.4_Missense_Mutation_p.P115L|TFEB_ENST00000373033.1_Missense_Mutation_p.P115L			P19484	TFEB_HUMAN	transcription factor EB	115				GSPKPPPAASPGVRAGHVLSSSAGNSAPN -> ALRNPHQP PPQGCELDTCCPPPLATVLPI (in Ref. 1; AAA36730).	embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	11	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			TGGGGGTTTCGGAGAGCCCTG	0.632000			T	ALPHA	renal (childhood epithelioid)								7	36					0	0	0.006214	0	0
ANKRD10	55608	broad.mit.edu	37	13	111558407	111558407	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:111558407G>A	ENST00000375758.5	-	3	562	c.428C>T	c.(427-429)gCc>gTc	p.A143V	ANKRD10_ENST00000310847.4_Missense_Mutation_p.A143V|ANKRD10_ENST00000489973.2_5'UTR|ANKRD10_ENST00000267339.2_Missense_Mutation_p.A143V			Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	143										central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)	9	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			CGCCACAAGGGCACTGATGCA	0.433000													3	9					0	0	0.004672	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92705993	92705993	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:92705993C>T	ENST00000318445.6	+	10	1975	c.1761C>T	c.(1759-1761)atC>atT	p.I587I	SLCO3A1_ENST00000555549.1_3'UTR|RP11-152L20.3_ENST00000561674.1_RNA|SLCO3A1_ENST00000424469.2_Silent_p.I587I	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	587					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			CAGGCTTCATCCCTCCACCCC	0.562000													19	56					0	0	0.007413	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	18014191	18014191	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:18014191G>A	ENST00000361221.3	+	27	3292	c.3133G>A	c.(3133-3135)Gag>Aag	p.E1045K	ARHGEF10L_ENST00000375408.3_Missense_Mutation_p.E818K|ARHGEF10L_ENST00000452522.1_Missense_Mutation_p.E1006K|ARHGEF10L_ENST00000434513.1_Missense_Mutation_p.E1040K|ARHGEF10L_ENST00000167825.4_Missense_Mutation_p.E748K|ARHGEF10L_ENST00000375415.1_Missense_Mutation_p.E1006K|ARHGEF10L_ENST00000469726.1_3'UTR	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	1045					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		TGAGACCCTGGAGCATCTGCA	0.642000													5	32					0	0	0.014758	0	0
MUC16	94025	broad.mit.edu	37	19	9062258	9062258	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:9062258G>A	ENST00000397910.4	-	3	25391	c.25188C>T	c.(25186-25188)tcC>tcT	p.S8396S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8398	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTCAGAAGTGGATATGGAAA	0.483000													27	22					0	0	0.004656	0	0
ATP1A3	478	broad.mit.edu	37	19	42492128	42492128	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:42492128C>T	ENST00000545399.1	-	4	509	c.356G>A	c.(355-357)gGt>gAt	p.G119D	ATP1A3_ENST00000602133.1_Missense_Mutation_p.G76D|ATP1A3_ENST00000302102.5_Missense_Mutation_p.G106D|ATP1A3_ENST00000543770.1_Missense_Mutation_p.G117D	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	106					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						CGCCTGGATACCGTAGGCCAG	0.622000													21	108					0	0	0.018920	0	0
GPR133	283383	broad.mit.edu	37	12	131622767	131622767	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:131622767C>T	ENST00000261654.5	+	24	3081	c.2522C>T	c.(2521-2523)tCg>tTg	p.S841L	GPR133_ENST00000376682.4_Missense_Mutation_p.S527L|GPR133_ENST00000540207.1_3'UTR|GPR133_ENST00000543617.1_Missense_Mutation_p.S360L|GPR133_ENST00000535015.1_Missense_Mutation_p.S873L	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	841					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CCCTTCCACTCGGACCTCGTG	0.622000													16	25					0	0	0.006122	0	0
RHO	6010	broad.mit.edu	37	3	129247891	129247891	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:129247891C>T	ENST00000296271.3	+	1	409	c.315C>T	c.(313-315)ttC>ttT	p.F105F		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	105					protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	ACTTCGTCTTCGGGCCCACAG	0.597000													35	87					0	0	0.021022	0	0
STMN2	11075	broad.mit.edu	37	8	80553665	80553665	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:80553665G>A	ENST00000220876.7	+	3	550	c.168G>A	c.(166-168)ctG>ctA	p.L56L	STMN2_ENST00000518491.1_Silent_p.L45L|STMN2_ENST00000518111.1_Silent_p.L56L	NM_001199214.1|NM_007029.3	NP_001186143.1|NP_008960.2	Q93045	STMN2_HUMAN	stathmin-like 2	56	Regulatory/phosphorylation domain (Potential).				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			CTTTTGAGCTGATCTTGAAGC	0.453000													15	53					0	0	0.003163	0	0
OR1N2	138882	broad.mit.edu	37	9	125316346	125316346	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:125316346C>T	ENST00000373688.2	+	1	956	c.898C>T	c.(898-900)Ccc>Tcc	p.P300S		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						GGTGATTATTCCCACGCTAAA	0.398000													12	35					0	0	0.016723	0	0
OR2A25	392138	broad.mit.edu	37	7	143771818	143771818	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:143771818G>A	ENST00000408898.2	+	1	544	c.506G>A	c.(505-507)gGa>gAa	p.G169E		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					TCCTTCTGTGGACCCCAGAAA	0.448000													69	127					0	0	0.014410	0	0
CD2	914	broad.mit.edu	37	1	117303229	117303229	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:117303229C>T	ENST00000369478.3	+	3	696	c.588C>T	c.(586-588)tcC>tcT	p.S196S		NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	196	Ig-like C2-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	GCAAGGAATCCAGTGTCGAGC	0.542000													8	22					0	0	0.003080	0	0
CERCAM	51148	broad.mit.edu	37	9	131196510	131196510	+	Splice_Site	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:131196510T>C	ENST00000372842.1	+	11	4241		c.e11+2		CERCAM_ENST00000372838.4_Splice_Site			Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule						cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				endometrium(2)|kidney(4)|large_intestine(2)|lung(9)|ovary(1)|pancreas(2)	20						GGACCTGATGTAGGCAGCCTG	0.637000													12	37					0	0	0.016723	0	0
SLC43A1	8501	broad.mit.edu	37	11	57263631	57263631	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:57263631A>G	ENST00000278426.3	-	7	920	c.565T>C	c.(565-567)Tac>Cac	p.Y189H	SLC43A1_ENST00000533515.1_5'UTR|SLC43A1_ENST00000528450.1_Missense_Mutation_p.Y189H	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	189					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						CCGGCATCGTAGATCAGCTGT	0.597000													12	27					0	0	0.020292	0	0
HERC1	8925	broad.mit.edu	37	15	64017698	64017698	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:64017698T>C	ENST00000443617.2	-	18	3448	c.3361A>G	c.(3361-3363)Att>Gtt	p.I1121V		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1121					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GCAGGATCAATTAGTTCTGGC	0.423000													27	58					0	0	0.007291	0	0
PRR22	163154	broad.mit.edu	37	19	5783676	5783676	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:5783676G>A	ENST00000419421.2	-	3	686	c.582C>T	c.(580-582)ccC>ccT	p.P194P		NM_001134316.1	NP_001127788.1	Q8IZ63	PRR22_HUMAN	proline rich 22	192	Pro-rich.									endometrium(2)|large_intestine(1)|prostate(1)|urinary_tract(1)	5						TGAGTACAGGGGGCGGCTTGT	0.721000													10	5					0	0	0.008291	0	0
OR51G2	81282	broad.mit.edu	37	11	4936029	4936029	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:4936029G>A	ENST00000322013.3	-	1	893	c.865C>T	c.(865-867)Cct>Tct	p.P289S	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCACAGGAGGAAAGAGAAGA	0.493000													4	12					0	0	0.009096	0	0
IGHA2	3494	broad.mit.edu	37	14	106053529	106053529	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:106053529C>T	ENST00000390539.2	-	0	767																											GGGGCAGCTCCTGTGACCCCT	0.662000													6	26					0	0	0.003080	0	0
TTN	7273	broad.mit.edu	37	2	179664595	179664595	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:179664595G>A	ENST00000589042.1	-	5	850	c.626C>T	c.(625-627)tCg>tTg	p.S209L	TTN_ENST00000591111.1_Missense_Mutation_p.S209L|TTN_ENST00000360870.5_Missense_Mutation_p.S209L|TTN_ENST00000359218.5_Missense_Mutation_p.S209L|TTN_ENST00000342992.6_Missense_Mutation_p.S209L|TTN_ENST00000342175.6_Missense_Mutation_p.S209L|TTN_ENST00000460472.2_Missense_Mutation_p.S209L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	209							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.S209L(5)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAGCAGTCGAAACAATTGT	0.418000													20	22					0	0	0.021523	0	0
ZBED6CL	113763	broad.mit.edu	37	7	150027718	150027718	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:150027718C>T	ENST00000343855.4	+	1	781	c.225C>T	c.(223-225)acC>acT	p.T75T	LRRC61_ENST00000323078.7_Intron|LRRC61_ENST00000359623.4_Intron|LRRC61_ENST00000493307.1_Intron	NM_138434.2	NP_612443.1			ZBED6 C-terminal like																		TGCTGGCCACCTTGCTGGACC	0.612000													31	91					0	0	0.007291	0	0
TNC	3371	broad.mit.edu	37	9	117800600	117800600	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:117800600T>C	ENST00000350763.4	-	20	5863	c.5452A>G	c.(5452-5454)Agg>Ggg	p.R1818G	TNC_ENST00000423613.2_Missense_Mutation_p.R1545G|TNC_ENST00000542877.1_Missense_Mutation_p.R1455G|TNC_ENST00000537320.1_Missense_Mutation_p.R1181G|TNC_ENST00000535648.1_Missense_Mutation_p.R1363G|TNC_ENST00000341037.4_Missense_Mutation_p.R1636G|TNC_ENST00000346706.3_Missense_Mutation_p.R1272G|TNC_ENST00000345230.3_Missense_Mutation_p.R1181G|TNC_ENST00000340094.3_Missense_Mutation_p.R1454G	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1818	Fibronectin type-III 14.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						GGCTGCCACCTGGCCAAGGCT	0.532000													13	47					0	0	0.020292	0	0
MARK3	4140	broad.mit.edu	37	14	103969316	103969316	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:103969316C>T	ENST00000429436.2	+	18	2524	c.2014C>T	c.(2014-2016)Ccc>Tcc	p.P672S	MARK3_ENST00000561071.1_3'UTR|MARK3_ENST00000335102.5_Missense_Mutation_p.P695S|MARK3_ENST00000303622.9_Missense_Mutation_p.P648S|MARK3_ENST00000216288.7_Missense_Mutation_p.P632S|MARK3_ENST00000553942.1_Missense_Mutation_p.P663S|MARK3_ENST00000440884.3_Missense_Mutation_p.P578S|MARK3_ENST00000416682.2_Missense_Mutation_p.P671S	NM_001128918.1|NM_001128919.1	NP_001122390.1|NP_001122391.1	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	672							ATP binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30		Melanoma(154;0.155)	Epithelial(46;0.241)			TTCAATGGATCCCGGGGACAT	0.507000													13	34					0	0	0.016723	0	0
FAM83E	54854	broad.mit.edu	37	19	49106801	49106801	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:49106801C>T	ENST00000263266.3	-	4	1315	c.1126G>A	c.(1126-1128)Gac>Aac	p.D376N		NM_017708.3	NP_060178.2	Q2M2I3	FA83E_HUMAN	family with sequence similarity 83, member E	376										NS(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(2)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CGGCTTAGGTCCCACATGGAG	0.687000													11	24					0	0	0.010729	0	0
KDR	3791	broad.mit.edu	37	4	55955863	55955863	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:55955863G>A	ENST00000263923.4	-	24	3594	c.3299C>T	c.(3298-3300)tCc>tTc	p.S1100F	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1100	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CTTACCTAAGGAAAATATTTC	0.413000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			25	69					0	0	0.007291	0	0
TARS2	80222	broad.mit.edu	37	1	150469026	150469026	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:150469026C>T	ENST00000369064.3	+	8	877	c.843C>T	c.(841-843)ttC>ttT	p.F281F	TARS2_ENST00000369054.2_Intron|TARS2_ENST00000438568.2_3'UTR|TARS2_ENST00000463555.1_Intron|TARS2_ENST00000606933.1_Intron	NM_025150.3	NP_079426.2	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	281					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	GGATTTCCTTCCCCACAACAG	0.532000													38	170					0	0	0.021022	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20495407	20495407	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:20495407G>A	ENST00000555186.1	+	0	610					NR_038836.1																						TTCTGTGTGAGGAAAATGAAT	0.393000													11	102					0	0	0.013537	0	0
TLN1	7094	broad.mit.edu	37	9	35700339	35700339	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:35700339G>A	ENST00000314888.9	-	49	6862	c.6509C>T	c.(6508-6510)tCt>tTt	p.S2170F	TLN1_ENST00000540444.1_Missense_Mutation_p.S2058F	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	2170					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TTCTGGGGTAGAGGTCTTGGC	0.527000													15	72					0	0	0.004007	0	0
CYP17A1	1586	broad.mit.edu	37	10	104596869	104596869	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:104596869C>T	ENST00000369887.3	-	1	421	c.250G>A	c.(250-252)Gag>Aag	p.E84K	CYP17A1_ENST00000489268.1_5'UTR	NM_000102.3	NP_000093.1	P05093	CP17A_HUMAN	cytochrome P450, family 17, subfamily A, polypeptide 1	84					androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	ATAAGCACCTCCTTGGCCAGC	0.532000													15	64					0	0	0.020292	0	0
CDH9	1007	broad.mit.edu	37	5	26890578	26890578	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:26890578G>A	ENST00000231021.4	-	8	1521	c.1349C>T	c.(1348-1350)tCa>tTa	p.S450L		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	450	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CCAAGGAGATGATTCCCGGTC	0.403000													12	62					0	0	0.010729	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19204081	19204081	+	Silent	SNP	G	G	A	rs150927009		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:19204081G>A	ENST00000375341.3	-	10	1223	c.966C>T	c.(964-966)ttC>ttT	p.F322F	RP13-279N23.2_ENST00000494072.3_3'UTR|ALDH4A1_ENST00000538309.1_Silent_p.F262F|ALDH4A1_ENST00000290597.5_Silent_p.F322F|ALDH4A1_ENST00000538839.1_Silent_p.F322F	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	322					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity	p.F322F(4)		cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	AGCGGTGCACGAAGTGGAAGT	0.657000													4	32					0	0	0.009096	0	0
FANK1	92565	broad.mit.edu	37	10	127693492	127693492	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:127693492G>A	ENST00000368695.1	+	7	683	c.561G>A	c.(559-561)gtG>gtA	p.V187V	FANK1_ENST00000477963.1_3'UTR|FANK1_ENST00000368693.1_Silent_p.V193V	NM_145235.3	NP_660278.3	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains 1	193						cytoplasm|nucleus				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(10)|ovary(1)|urinary_tract(1)	21		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				TAGATGTTGTGAAATATCTCC	0.527000													38	109					0	0	0.006230	0	0
SRGN	5552	broad.mit.edu	37	10	70863760	70863760	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:70863760C>T	ENST00000242465.3	+	3	401	c.361C>T	c.(361-363)Caa>Taa	p.Q121*	SRGN_ENST00000462445.1_3'UTR	NM_002727.2	NP_002718.2	P10124	SRGN_HUMAN	serglycin	121					apoptosis|biomineral tissue development|maintenance of granzyme B location in T cell secretory granule|maintenance of protease location in mast cell secretory granule|negative regulation of bone mineralization|negative regulation of cytokine secretion|platelet activation|platelet degranulation|protein maturation by peptide bond cleavage	extracellular space|mast cell granule|platelet alpha granule lumen				large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(3)	7						ACAGGATTACCAACTAGTAGA	0.512000													10	34					0	0	0.008291	0	0
OR2A14	135941	broad.mit.edu	37	7	143827081	143827081	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:143827081G>A	ENST00000408899.2	+	1	931	c.876G>A	c.(874-876)agG>agA	p.R292R		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					ATAGCCTAAGGAATGCAGAGG	0.557000													51	192					0	0	0.014410	0	0
KARS	3735	broad.mit.edu	37	16	75681539	75681539	+	Translation_Start_Site	SNP	T	T	A	rs138776538		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:75681539T>A	ENST00000319410.5	-	0	24				KARS_ENST00000302445.3_De_novo_Start_InFrame	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase						interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	GGCCGCCATCTTCCCGGAGGG	0.597000													6	17					0	0	0.004482	0	0
EMR1	2015	broad.mit.edu	37	19	6903930	6903930	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:6903930G>A	ENST00000312053.4	+	7	808	c.771G>A	c.(769-771)ttG>ttA	p.L257L	EMR1_ENST00000450315.3_Intron|EMR1_ENST00000381404.4_Silent_p.L205L|EMR1_ENST00000250572.8_Silent_p.L257L|EMR1_ENST00000381407.5_Silent_p.L116L	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	257	EGF-like 5; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					ATGGACAGTTGAATTTCACAG	0.453000													15	51					0	0	0.003163	0	0
LRRC55	219527	broad.mit.edu	37	11	56950032	56950032	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:56950032T>C	ENST00000497933.1	+	1	812	c.665T>C	c.(664-666)cTg>cCg	p.L222P		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	192	LRRCT.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						TTCCTCAGCCTGGAGGCTCTT	0.652000													37	74					0	0	0.005524	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166494	140166494	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:140166494G>A	ENST00000504120.2	+	1	619	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	PCDHA1_ENST00000394633.3_Missense_Mutation_p.E207K|PCDHA1_ENST00000378133.3_Missense_Mutation_p.E207K	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAACACCAGAACTTCACTT	0.448000													47	46					0	0	0.014410	0	0
ADCY10	55811	broad.mit.edu	37	1	167779006	167779006	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:167779006C>T	ENST00000367848.1	-	33	4963	c.4466G>A	c.(4465-4467)tGg>tAg	p.W1489*	ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Nonsense_Mutation_p.W1581*|ADCY10_ENST00000545172.1_Nonsense_Mutation_p.W1428*			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1581					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AATTTTTTCCCATGATGGGAG	0.388000													39	47					0	0	0.005524	0	0
GTSE1	51512	broad.mit.edu	37	22	46724623	46724623	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:46724623C>T	ENST00000454366.1	+	10	1975	c.1763C>T	c.(1762-1764)tCc>tTc	p.S588F		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	569					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		AAGACAGATTCCAGGCTGGTG	0.468000													25	84					0	0	0.010818	0	0
C1orf173	127254	broad.mit.edu	37	1	75078373	75078373	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:75078373G>A	ENST00000326665.5	-	9	1339	c.1121C>T	c.(1120-1122)tCc>tTc	p.S374F	C1orf173_ENST00000420661.2_Missense_Mutation_p.S177F|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	374										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCCAAGCCTGGAACCTTTCCG	0.463000													12	29					0	0	0.016723	0	0
LILRA3	11026	broad.mit.edu	37	19	54803734	54803734	+	Silent	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:54803734G>T	ENST00000391745.1	-	7	457	c.141C>A	c.(139-141)acC>acA	p.T47T	LILRA3_ENST00000391744.3_Silent_p.T30T|LILRA3_ENST00000251390.3_Silent_p.T30T					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAGCCCAGAGGGTGGGCTTGG	0.562000													26	73					7.01153e-11	7.36455e-11	0.007291	1	0
MORC1	27136	broad.mit.edu	37	3	108682317	108682317	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:108682317C>T	ENST00000232603.5	-	27	2825	c.2743G>A	c.(2743-2745)Gat>Aat	p.D915N	MORC1_ENST00000483760.1_Missense_Mutation_p.D894N	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	915					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTCAGCTTATCCTCAGAGATT	0.353000													13	42					0	0	0.016723	0	0
PRAMEF18	391003	broad.mit.edu	37	1	13475031	13475031	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:13475031G>A	ENST00000376126.2	-	3	1097	c.1098C>T	c.(1096-1098)ctC>ctT	p.L366L		NM_001099850.1	NP_001093320.1	Q5VWM3	PRA18_HUMAN	PRAME family member 18	366										lung(2)|ovary(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGATGACCCTGAGTTTGGAGT	0.572000													105	278					0	0	0.014410	0	0
SLC9A2	6549	broad.mit.edu	37	2	103324924	103324924	+	Silent	SNP	C	C	T	rs112482803		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:103324924C>T	ENST00000233969.2	+	12	2557	c.2415C>T	c.(2413-2415)gcC>gcT	p.A805A		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	805						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						GCCGGAAAGCCCGATTTGGGA	0.562000													39	68					0	0	0.007835	0	0
NOD1	10392	broad.mit.edu	37	7	30492619	30492619	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:30492619G>A	ENST00000222823.4	-	6	939	c.414C>T	c.(412-414)ggC>ggT	p.G138G	NOD1_ENST00000423334.2_Silent_p.G138G	NM_006092.2	NP_006083.1	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain containing 1	138					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						TGGAGTCACGGCCCAGATGGT	0.582000													22	51					0	0	0.016522	0	0
EVC2	132884	broad.mit.edu	37	4	5667321	5667321	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:5667321G>A	ENST00000310917.2	-	8	1417	c.686C>T	c.(685-687)tCc>tTc	p.S229F	EVC2_ENST00000344938.1_Missense_Mutation_p.S309F|EVC2_ENST00000344408.5_Missense_Mutation_p.S309F	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	309						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						CAGCACAAGGGAGAGGAGGAA	0.577000													15	35					0	0	0.020292	0	0
CACNA1C	775	broad.mit.edu	37	12	2797764	2797764	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:2797764C>T	ENST00000399655.1	+	46	6201	c.5936C>T	c.(5935-5937)tCc>tTc	p.S1979F	CACNA1C_ENST00000399638.1_Missense_Mutation_p.S2007F|CACNA1C_ENST00000399601.1_Missense_Mutation_p.S1979F|CACNA1C_ENST00000399591.1_Missense_Mutation_p.S1987F|CACNA1C_ENST00000344100.3_Missense_Mutation_p.S2020F|CACNA1C_ENST00000399606.1_Missense_Mutation_p.S1999F|CACNA1C_ENST00000399644.1_Missense_Mutation_p.S1979F|CACNA1C_ENST00000406454.3_Missense_Mutation_p.S2050F|CACNA1C_ENST00000399603.1_Missense_Mutation_p.S1979F|CACNA1C_ENST00000347598.4_Missense_Mutation_p.S2027F|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000399641.1_Missense_Mutation_p.S1979F|CACNA1C_ENST00000327702.7_Missense_Mutation_p.S2014F|CACNA1C_ENST00000399621.1_Missense_Mutation_p.S1998F|CACNA1C_ENST00000399595.1_Missense_Mutation_p.S1987F|CACNA1C_ENST00000399634.1_Missense_Mutation_p.S2050F|CACNA1C_ENST00000399597.1_Missense_Mutation_p.S1979F|CACNA1C_ENST00000399629.1_Missense_Mutation_p.S1996F|CACNA1C_ENST00000399617.1_Missense_Mutation_p.S2014F|CACNA1C_ENST00000402845.3_Missense_Mutation_p.S1998F|CACNA1C_ENST00000399649.1_Missense_Mutation_p.S1985F|CACNA1C_ENST00000335762.5_Missense_Mutation_p.S2004F|CACNA1C_ENST00000399637.1_Missense_Mutation_p.S1998F	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	2062					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGGGTCGAGTCCAGTGAGAAA	0.697000													20	55					0	0	0.007413	0	0
CASP1	834	broad.mit.edu	37	11	104900534	104900534	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:104900534C>T	ENST00000533400.1	-	6	755	c.720G>A	c.(718-720)cgG>cgA	p.R240R	CASP1_ENST00000528974.1_Silent_p.R201R|CASP1_ENST00000393136.4_Silent_p.R219R|CASP1_ENST00000598974.1_Silent_p.R240R|CASP1_ENST00000525825.1_Silent_p.R219R|CASP1_ENST00000534497.1_Silent_p.R147R|CASP1_ENST00000593315.1_Silent_p.R219R|CASP1_ENST00000353247.5_Intron|CASP1_ENST00000415981.2_Intron|CASP1_ENST00000526568.1_Silent_p.R147R|CASP1_ENST00000594519.1_Silent_p.R147R|CASP1_ENST00000436863.3_Silent_p.R240R|CASP1_ENST00000446369.1_Silent_p.R147R|CASP1_ENST00000527979.1_Silent_p.R203R|CASP1_ENST00000531166.1_Intron	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	240					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	AAATGCCTTCCCGAATACCAT	0.463000													12	32					0	0	0.010729	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32502640	32502640	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:32502640C>T	ENST00000327300.7	+	5	1068	c.901C>T	c.(901-903)Ccc>Tcc	p.P301S	KHDRBS1_ENST00000492989.1_Missense_Mutation_p.P262S|KHDRBS1_ENST00000307714.8_3'UTR	NM_006559.1	NP_006550.1	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal transduction associated 1	301	Pro-rich.				cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACCACCTGTTCCCAGGTAAAA	0.493000													21	65					0	0	0.014323	0	0
PTPRH	5794	broad.mit.edu	37	19	55711784	55711784	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:55711784G>A	ENST00000376350.3	-	7	1262	c.1240C>T	c.(1240-1242)Cct>Tct	p.P414S	PTPRH_ENST00000263434.5_Missense_Mutation_p.P236S|PTPRH_ENST00000588559.1_5'UTR	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	414	Fibronectin type-III 5.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TAGTCCTGAGGGTATGGGCCA	0.547000													33	63					0	0	0.015359	0	0
FER1L6	654463	broad.mit.edu	37	8	124989720	124989720	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:124989720G>A	ENST00000522917.1	+	10	1140	c.934G>A	c.(934-936)Gaa>Aaa	p.E312K	FER1L6_ENST00000399018.1_Missense_Mutation_p.E312K	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	312	C2 2.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GATCTTCAAGGAAATGTTCCC	0.507000													46	73					0	0	0.014410	0	0
CCDC158	339965	broad.mit.edu	37	4	77317556	77317556	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:77317556G>A	ENST00000388914.3	-	3	306	c.154C>T	c.(154-156)Cct>Tct	p.P52S	CCDC158_ENST00000504868.1_5'UTR|CCDC158_ENST00000434846.2_Missense_Mutation_p.P52S	NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	52										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						GGGAAAAAAGGAACCTGTGTC	0.343000													9	22					0	0	0.010729	0	0
CCDC88B	283234	broad.mit.edu	37	11	64120576	64120576	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:64120576G>A	ENST00000356786.5	+	21	3595	c.3551G>A	c.(3550-3552)gGt>gAt	p.G1184D	CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000301897.4_5'UTR|CCDC88B_ENST00000359902.2_Missense_Mutation_p.G336D	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	1184					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GAGCTGCAGGGTGAACGCGGG	0.687000													5	15					0	0	0.014758	0	0
PSME4	23198	broad.mit.edu	37	2	54133982	54133982	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:54133982G>A	ENST00000404125.1	-	25	2863	c.2808C>T	c.(2806-2808)atC>atT	p.I936I	PSME4_ENST00000421748.2_Silent_p.I80I	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	936					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ACAGTGCTCTGATATGTTGTT	0.323000													9	45					0	0	0.008291	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073303	17073303	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:17073303G>A	ENST00000359963.3	-	1	397	c.138C>T	c.(136-138)gtC>gtT	p.V46V		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	46					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AAGGCCGGATGACACTGGCCA	0.642000													20	68					0	0	0.012319	0	0
CCDC77	84318	broad.mit.edu	37	12	539842	539842	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:539842C>T	ENST00000239830.4	+	7	702	c.523C>T	c.(523-525)Caa>Taa	p.Q175*	CCDC77_ENST00000412006.2_Nonsense_Mutation_p.Q143*|CCDC77_ENST00000540180.1_Nonsense_Mutation_p.Q143*|CCDC77_ENST00000540344.1_3'UTR|CCDC77_ENST00000422000.1_Nonsense_Mutation_p.Q143*	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	175						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			CACCATTCTCCAAAAGACTAT	0.378000													26	72					0	0	0.009535	0	0
ZNF750	79755	broad.mit.edu	37	17	80789372	80789372	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:80789372C>T	ENST00000269394.3	-	2	1792	c.959G>A	c.(958-960)gGa>gAa	p.G320E	ZNF750_ENST00000572562.1_Intron|TBCD_ENST00000539345.2_Intron|TBCD_ENST00000397466.2_Intron|TBCD_ENST00000355528.4_Intron	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	320						intracellular	zinc ion binding	p.G320E(1)		NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CCTGTAAAATCCGTAAGGAAT	0.542000													108	126					0	0	0.014410	0	0
PPFIA1	8500	broad.mit.edu	37	11	70185379	70185379	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:70185379C>T	ENST00000253925.7	+	14	1889	c.1674C>T	c.(1672-1674)ggC>ggT	p.G558G	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Silent_p.G558G	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	558					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CACAGAAAGGCCGGCTGGCAG	0.572000													18	50					0	0	0.008871	0	0
TTN	7273	broad.mit.edu	37	2	179650858	179650858	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:179650858C>G	ENST00000589042.1	-	14	2311	c.2087G>C	c.(2086-2088)gGa>gCa	p.G696A	TTN_ENST00000591111.1_Missense_Mutation_p.G696A|TTN_ENST00000360870.5_Missense_Mutation_p.G696A|TTN_ENST00000359218.5_Missense_Mutation_p.G650A|TTN_ENST00000342992.6_Missense_Mutation_p.G696A|TTN_ENST00000342175.6_Missense_Mutation_p.G650A|TTN_ENST00000460472.2_Missense_Mutation_p.G650A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	696							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.G650E(3)|p.G696E(2)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCTTTTTTCCAACGTCCAC	0.507000													3	23					0	0	0.004672	0	0
TIE1	7075	broad.mit.edu	37	1	43775076	43775076	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:43775076G>A	ENST00000441333.2	+	7	931	c.931G>A	c.(931-933)Gga>Aga	p.G311R	TIE1_ENST00000372476.3_Silent_p.V402V|TIE1_ENST00000433781.2_Silent_p.V47V			P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	312	EGF-like 3.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGGCCATTGTGGAGCCAGAGA	0.607000													18	52					0	0	0.007413	0	0
WDR88	126248	broad.mit.edu	37	19	33639704	33639704	+	Silent	SNP	C	C	T	rs112724972	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:33639704C>T	ENST00000361680.2	+	5	645	c.567C>T	c.(565-567)atC>atT	p.I189I	WDR88_ENST00000592765.1_3'UTR|WDR88_ENST00000355868.3_Silent_p.I189I			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	189								p.I189I(1)		breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					ATACCTTCATCGTCTCCTGTA	0.463000													26	107					0	0	0.004656	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603001	111603001	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:111603001C>T	ENST00000431670.2	+	2	488	c.77C>T	c.(76-78)tCt>tTt	p.S26F	PHLDB2_ENST00000412622.1_Missense_Mutation_p.S26F|PHLDB2_ENST00000477695.1_Missense_Mutation_p.S26F|PHLDB2_ENST00000393925.3_Missense_Mutation_p.S26F|PHLDB2_ENST00000478922.1_Missense_Mutation_p.S26F|PHLDB2_ENST00000481953.1_Missense_Mutation_p.S26F|PHLDB2_ENST00000393923.3_Missense_Mutation_p.S53F	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	26						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GTGGTGCATTCTGTTGAGAAC	0.408000													31	69					0	0	0.012213	0	0
FLT4	2324	broad.mit.edu	37	5	180057580	180057580	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:180057580G>A	ENST00000261937.6	-	3	453	c.375C>T	c.(373-375)gcC>gcT	p.A125A	FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000502649.1_Silent_p.A125A|FLT4_ENST00000393347.3_Silent_p.A125A	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	125	Ig-like C2-type 1.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AGGAGCTGGCGGCCGTGGTGC	0.642000													7	36					0	0	0.001984	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175380	143175380	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:143175380C>T	ENST00000408916.1	+	1	415	c.415C>T	c.(415-417)Ctg>Ttg	p.L139L	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	139					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					GGGCTCTGTCCTGATCTCCTT	0.463000													13	41					0	0	0.020292	0	0
TENM1	10178	broad.mit.edu	37	X	123518401	123518401	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:123518401G>A	ENST00000422452.2	-	30	6443	c.6380C>T	c.(6379-6381)gCc>gTc	p.A2127V	TENM1_ENST00000371130.3_Missense_Mutation_p.A2120V|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CATCCAGTAGGCAATTGCCTT	0.378000													14	6					0	0	0.020292	0	0
SPRY3	10251	broad.mit.edu	37	X	155004002	155004002	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:155004002C>T	ENST00000302805.2	+	2	900	c.469C>T	c.(469-471)Ccc>Tcc	p.P157S		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	157	Cys-rich.|SPR.				multicellular organismal development|regulation of signal transduction	cytoplasm|membrane						all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CAAGTGCGTCCCCTGCACAGC	0.592000													27	94					0	0	0.006320	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198172	170198172	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:170198172G>A	ENST00000231706.4	-	7	2214	c.1899C>T	c.(1897-1899)ccC>ccT	p.P633P	CLDN11_ENST00000451576.1_Intron|CLDN11_ENST00000486975.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	633						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CAGGCACAAAGGGGAGGCAAG	0.547000													24	137					0	0	0.018920	0	0
CADM1	23705	broad.mit.edu	37	11	115099882	115099882	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:115099882G>A	ENST00000542447.2	-	5	800	c.672C>T	c.(670-672)caC>caT	p.H224H	CADM1_ENST00000537140.1_5'UTR|CADM1_ENST00000452722.2_Silent_p.H224H|CADM1_ENST00000536727.1_Silent_p.H224H|CADM1_ENST00000537058.1_Silent_p.H224H|CADM1_ENST00000331581.6_Silent_p.H224H	NM_001098517.1	NP_001091987.1	Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	224	Ig-like C2-type 1.				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		TGACCGCAGGGTGCTCCACCT	0.532000													10	17					0	0	0.006214	0	0
NLRP5	126206	broad.mit.edu	37	19	56549442	56549442	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:56549442C>T	ENST00000390649.3	+	10	2667	c.2667C>T	c.(2665-2667)atC>atT	p.I889I		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	889						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TCTCCCAAATCCTTACGACCT	0.537000													21	54					0	0	0.012319	0	0
ZFP90	146198	broad.mit.edu	37	16	68598164	68598164	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:68598164C>T	ENST00000570495.1	+	5	1766	c.1474C>T	c.(1474-1476)Cct>Tct	p.P492S	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000398253.2_Missense_Mutation_p.P492S|ZFP90_ENST00000563169.2_Missense_Mutation_p.P492S			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	492					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		TATTTCTCATCCTGGAGAGAA	0.408000													14	28					0	0	0.020292	0	0
ARPP21	10777	broad.mit.edu	37	3	35834018	35834018	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:35834018A>T	ENST00000187397.4	+	19	2633	c.2177A>T	c.(2176-2178)tAt>tTt	p.Y726F	ARPP21_ENST00000444190.1_Missense_Mutation_p.Y707F|ARPP21_ENST00000337271.5_Missense_Mutation_p.Y707F|ARPP21_ENST00000417925.1_Missense_Mutation_p.Y727F|ARPP21_ENST00000458225.1_Missense_Mutation_p.Y727F|ARPP21_ENST00000476052.1_3'UTR	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	726	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						ATGTCTTCTTATCAGGTGCTC	0.478000													8	24					0	0	0.006214	0	0
CNTN3	5067	broad.mit.edu	37	3	74347335	74347335	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:74347335G>A	ENST00000263665.6	-	17	2201	c.2174C>T	c.(2173-2175)cCt>cTt	p.P725L		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	725	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TAGTTCTTCAGGGACTGGCTA	0.453000													8	11					0	0	0.003080	0	0
RFX4	5992	broad.mit.edu	37	12	107113834	107113834	+	Splice_Site	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:107113834T>C	ENST00000392842.1	+	12	1647		c.e12+2		RFX4_ENST00000229387.5_Splice_Site|RFX4_ENST00000357881.4_Splice_Site|RP11-144F15.1_ENST00000551505.1_Intron|RP11-482D24.3_ENST00000552415.1_RNA	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)						transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						GTTGTGAAGGTTGGTAAACCG	0.537000													22	54					0	0	0.016522	0	0
TM9SF4	9777	broad.mit.edu	37	20	30747794	30747794	+	Splice_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:30747794G>A	ENST00000217315.5	+	16	1858		c.e16-1		TM9SF4_ENST00000398022.2_Splice_Site			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4							integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TGTGTCCACAGGCTATCTGGG	0.517000													14	42					0	0	0.016723	0	0
E2F8	79733	broad.mit.edu	37	11	19246337	19246337	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:19246337G>A	ENST00000527884.1	-	13	2704	c.2472C>T	c.(2470-2472)ttC>ttT	p.F824F	E2F8_ENST00000250024.4_Silent_p.F824F|RP11-428C19.4_ENST00000527978.1_RNA	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	824					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CTGGGGTACGGAAGAAACTTT	0.488000													10	62					0	0	0.008291	0	0
PGM2	55276	broad.mit.edu	37	4	37847295	37847295	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:37847295T>G	ENST00000381967.4	+	8	1051	c.951T>G	c.(949-951)atT>atG	p.I317M	PGM2_ENST00000537241.1_Missense_Mutation_p.I157M|PGM2_ENST00000544359.1_Missense_Mutation_p.I178M	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	317					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						AGGCCAGAATTGTTTTAGCTA	0.338000													31	75					0	0	0.017118	0	0
MAP9	79884	broad.mit.edu	37	4	156289808	156289808	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:156289808G>A	ENST00000311277.4	-	5	901	c.638C>T	c.(637-639)tCc>tTc	p.S213F	AC097467.2_ENST00000596165.1_RNA|MAP9_ENST00000379248.2_Missense_Mutation_p.S140F|AC097467.2_ENST00000597831.1_RNA|MAP9_ENST00000515654.1_Missense_Mutation_p.S213F	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	213					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CGTTGGAAGGGAAGAAGGTGC	0.403000													27	66					0	0	0.006320	0	0
KCNJ10	3766	broad.mit.edu	37	1	160011970	160011970	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:160011970G>A	ENST00000368089.3	-	2	579	c.353C>T	c.(352-354)gCc>gTc	p.A118V	KCNJ10_ENST00000509700.1_5'UTR	NM_002241.4	NP_002232.2	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 10	118						integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)	17	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GAAGAGGAAGGCTCCAGTGAG	0.572000													25	100					0	0	0.021523	0	0
VEGFC	7424	broad.mit.edu	37	4	177650815	177650815	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:177650815C>T	ENST00000280193.2	-	2	648	c.233G>A	c.(232-234)tGg>tAg	p.W78*		NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	78					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GTACATTTTCCAATATTCTGG	0.428000													4	17					0	0	0.009096	0	0
DYRK4	8798	broad.mit.edu	37	12	4705788	4705788	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:4705788C>T	ENST00000540757.2	+	6	613	c.453C>T	c.(451-453)atC>atT	p.I151I	DYRK4_ENST00000010132.5_Silent_p.I151I|DYRK4_ENST00000543431.1_Silent_p.I151I	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	151	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			AGCTGAAGATCCTGGAAGCTC	0.498000													10	20					0	0	0.008291	0	0
CBLB	868	broad.mit.edu	37	3	105378048	105378048	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:105378048G>A	ENST00000264122.4	-	19	3036	c.2715C>T	c.(2713-2715)ccC>ccT	p.P905P	CBLB_ENST00000407712.1_Silent_p.P120P|CBLB_ENST00000394027.3_Silent_p.P883P	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	905	Interaction with SH3KBP1.|Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						GTGGTTTAGGGGGTCTGGCTG	0.433000			Mis S		AML								5	25					0	0	0.001168	0	0
ZNF589	51385	broad.mit.edu	37	3	48310173	48310173	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:48310173C>T	ENST00000354698.3	+	4	1064	c.992C>T	c.(991-993)tCg>tTg	p.S331L	ZNF589_ENST00000427617.2_Intron|ZNF589_ENST00000412564.1_Intron|ZNF589_ENST00000440261.2_Intron	NM_016089.2	NP_057173.2	Q86UQ0	ZN589_HUMAN	zinc finger protein 589	331					regulation of transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(193;0.000649)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGGGAGAAATCGTTTATGTGC	0.502000													28	81					0	0	0.008361	0	0
IFNAR2	3455	broad.mit.edu	37	21	34621083	34621083	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:34621083C>T	ENST00000404220.3	+	6	793	c.464C>T	c.(463-465)cCa>cTa	p.P155L	AP000295.9_ENST00000433395.2_Missense_Mutation_p.H63Y|IFNAR2_ENST00000382241.3_Missense_Mutation_p.P155L|IFNAR2_ENST00000382264.3_Missense_Mutation_p.P155L|IFNAR2_ENST00000342101.3_Missense_Mutation_p.P155L|IFNAR2_ENST00000342136.4_Missense_Mutation_p.P155L|IFNAR2_ENST00000413881.1_Missense_Mutation_p.P83L			P48551	INAR2_HUMAN	interferon (alpha, beta and omega) receptor 2	155					JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	11					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	GTGAAATTTCCATCTATTGTT	0.363000													29	88					0	0	0.010818	0	0
KALRN	8997	broad.mit.edu	37	3	124390670	124390670	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:124390670C>T	ENST00000360013.3	+	48	6991	c.6864C>T	c.(6862-6864)ccC>ccT	p.P2288P	KALRN_ENST00000428018.2_Silent_p.P559P|KALRN_ENST00000459915.1_Silent_p.P380P|KALRN_ENST00000291478.4_Silent_p.P591P|KALRN_ENST00000393496.1_Silent_p.P629P	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2287					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CTCTGCCTCCCCTGAAGATAT	0.577000													35	77					0	0	0.013726	0	0
STC1	6781	broad.mit.edu	37	8	23709810	23709810	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:23709810C>T	ENST00000290271.2	-	2	489	c.206G>A	c.(205-207)gGg>gAg	p.G69E	STC1_ENST00000524323.1_5'UTR	NM_003155.2	NP_003146.1	P52823	STC1_HUMAN	stanniocalcin 1	69					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GTCATACATCCCATCTGTGTC	0.483000													18	32					0	0	0.007413	0	0
RPS20	6224	broad.mit.edu	37	8	56986630	56986630	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:56986630G>A	ENST00000519807.1	-	2	217	c.92C>T	c.(91-93)tCc>tTc	p.S31F	RPS20_ENST00000519606.1_Missense_Mutation_p.S31F|RPS20_ENST00000518875.1_Missense_Mutation_p.S31F|RPS20_ENST00000521262.1_Missense_Mutation_p.S31F|RPS20_ENST00000524349.1_5'UTR|RPS20_ENST00000009589.3_Missense_Mutation_p.S31F|RPS20_ENST00000520627.1_Intron|RPS20_ENST00000523936.1_Missense_Mutation_p.S31F|RPS20_ENST00000520490.1_5'UTR	NM_001146227.1	NP_001139699.1	P60866	RS20_HUMAN	ribosomal protein S20	31					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome						all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			CTTTTCCAAGGATTTTACGTT	0.488000													16	88					0	0	0.008361	0	0
KIF2B	84643	broad.mit.edu	37	17	51900695	51900695	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:51900695G>A	ENST00000268919.4	+	1	457	c.301G>A	c.(301-303)Gcg>Acg	p.A101T		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	101					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CTTGGCTCTGGCGCCCTCTTC	0.597000													79	129					0	0	0.014410	0	0
DLGAP4	22839	broad.mit.edu	37	20	35060380	35060380	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:35060380C>T	ENST00000373913.3	+	3	740	c.260C>T	c.(259-261)cCc>cTc	p.P87L	DLGAP4_ENST00000339266.5_Missense_Mutation_p.P87L|DLGAP4_ENST00000401952.2_Missense_Mutation_p.P87L|DLGAP4_ENST00000373907.2_Missense_Mutation_p.P87L			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	87					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				GAGGAGAGCCCCTTCCCCAGC	0.627000													28	55					0	0	0.008361	0	0
MYH7B	57644	broad.mit.edu	37	20	33588110	33588110	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:33588110G>A	ENST00000262873.7	+	37	5014	c.4922G>A	c.(4921-4923)cGa>cAa	p.R1641Q		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1599						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AACCACCAGCGAGCTGTGGAG	0.602000													73	190					0	0	0.014410	0	0
NCAM2	4685	broad.mit.edu	37	21	22790801	22790801	+	Silent	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:22790801T>C	ENST00000400546.1	+	11	1641	c.1392T>C	c.(1390-1392)ccT>ccC	p.P464P	NCAM2_ENST00000284894.7_Silent_p.P322P	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	464	Ig-like C2-type 5.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		AGATTGCACCTACATCTGACA	0.323000													26	82					0	0	0.010818	0	0
AOAH	313	broad.mit.edu	37	7	36616196	36616196	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:36616196C>T	ENST00000431169.1	-	13	1305	c.1005G>A	c.(1003-1005)caG>caA	p.Q335Q	AOAH_ENST00000258749.5_Silent_p.Q335Q|AOAH_ENST00000535891.1_Silent_p.Q303Q|AOAH_ENST00000538464.1_Silent_p.Q57Q	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	335					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						TTGAAATATTCTGGTAGTCCC	0.303000													8	33					0	0	0.004482	0	0
FBXO3	26273	broad.mit.edu	37	11	33790446	33790446	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:33790446G>A	ENST00000530401.1	-	3	314	c.294C>T	c.(292-294)ctC>ctT	p.L98L	FBXO3_ENST00000265651.3_Silent_p.L103L|FBXO3_ENST00000448981.2_Silent_p.L103L|FBXO3_ENST00000526785.1_5'UTR|FBXO3_ENST00000534136.1_Silent_p.L103L|FBXO3_ENST00000533103.1_5'UTR			Q9UK99	FBX3_HUMAN	F-box protein 3	103				IKK -> VKR (in Ref. 2; CAB66560).	proteolysis	nucleus	ubiquitin-protein ligase activity			NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|pancreas(1)|stomach(1)	13		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		AATATTTCTTGAGATCATCCC	0.403000													46	90					0	0	0.014410	0	0
C10orf71	118461	broad.mit.edu	37	10	50532358	50532358	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:50532358A>C	ENST00000374144.3	+	3	2056	c.1768A>C	c.(1768-1770)Act>Cct	p.T590P	C10orf71_ENST00000323868.4_Missense_Mutation_p.T590P			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	590										endometrium(1)	1						CAGCTATCTAACTCTTAGCAC	0.532000													8	24					0	0	0.006214	0	0
ZNF668	79759	broad.mit.edu	37	16	31072471	31072471	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:31072471G>A	ENST00000538906.1	-	3	2562	c.1778C>T	c.(1777-1779)aCc>aTc	p.T593I	ZNF668_ENST00000426488.2_Missense_Mutation_p.T616I|ZNF668_ENST00000539836.3_Missense_Mutation_p.T616I|ZNF668_ENST00000535577.1_Missense_Mutation_p.T593I|ZNF668_ENST00000394983.2_Missense_Mutation_p.T593I|ZNF668_ENST00000300849.4_Missense_Mutation_p.T593I	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	593					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						CACAGGGTGGGTGCGTTCATG	0.652000													34	58					0	0	0.013726	0	0
TFAP2C	7022	broad.mit.edu	37	20	55209305	55209305	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:55209305C>T	ENST00000201031.2	+	5	1146	c.903C>T	c.(901-903)ctC>ctT	p.L301L	TFAP2C_ENST00000544508.1_Silent_p.L132L	NM_003222.3	NP_003213.1	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	301	H-S-H (helix-span-helix), dimerization.				cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			Colorectal(105;0.229)			ATGTGACTCTCCTGACATCCT	0.463000													9	31					0	0	0.006214	0	0
HGF	3082	broad.mit.edu	37	7	81372669	81372669	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:81372669C>T	ENST00000222390.5	-	7	1091	c.865_splice	c.e7+1	p.A289_splice	HGF_ENST00000444829.2_Splice_Site_p.E289_splice|HGF_ENST00000457544.2_Splice_Site_p.A284_splice|HGF_ENST00000453411.1_Splice_Site_p.E284_splice	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	289					epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						CTTCACTTACCGCATGTTTTA	0.448000													9	23					0	0	0.004482	0	0
TTN	7273	broad.mit.edu	37	2	179433986	179433986	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:179433986G>A	ENST00000589042.1	-	326	77097	c.76873C>T	c.(76873-76875)Cct>Tct	p.P25625S	TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P23984S|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P16685S|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P23057S|TTN_ENST00000342175.6_Missense_Mutation_p.P16752S|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P16560S|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000591332.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23984							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAACAAAGGAGGTTCCCAT	0.403000													28	91					0	0	0.006320	0	0
KCNH4	23415	broad.mit.edu	37	17	40328260	40328260	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:40328260C>T	ENST00000264661.3	-	5	973	c.641G>A	c.(640-642)gGg>gAg	p.G214E	KCNH4_ENST00000607371.1_Missense_Mutation_p.G214E	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	214					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GCAGCGAGACCCCCCCACGGA	0.607000													28	158					0	0	0.008361	0	0
NLRP5	126206	broad.mit.edu	37	19	56515291	56515291	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:56515291C>T	ENST00000390649.3	+	2	272	c.272C>T	c.(271-273)tCg>tTg	p.S91L		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	91	DAPIN.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TCTTCAGAATCGACCACATGC	0.453000													21	37					0	0	0.008871	0	0
HID1	283987	broad.mit.edu	37	17	72959095	72959095	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:72959095C>T	ENST00000425042.2	-	4	546	c.469G>A	c.(469-471)Gac>Aac	p.D157N	HID1_ENST00000532900.1_5'UTR	NM_030630.2	NP_085133.1			HID1 domain containing																		ACCGTGAAGTCCGGGCAGAAG	0.677000													7	62					0	0	0.001984	0	0
BCO2	83875	broad.mit.edu	37	11	112084579	112084579	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:112084579G>A	ENST00000357685.5	+	9	1462	c.1327G>A	c.(1327-1329)Gga>Aga	p.G443R	BCO2_ENST00000532593.1_Missense_Mutation_p.G338R|BCO2_ENST00000531169.1_Missense_Mutation_p.G409R|BCO2_ENST00000393032.2_Missense_Mutation_p.G409R|BCO2_ENST00000361053.4_Missense_Mutation_p.G370R|BCO2_ENST00000526088.1_Missense_Mutation_p.G409R|BCO2_ENST00000438022.1_Missense_Mutation_p.G409R			Q9BYV7	BCDO2_HUMAN	beta-carotene oxygenase 2	443					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)	16						ACAGGCTGATGGAACGGTATG	0.398000													40	94					0	0	0.009718	0	0
ZNF761	388561	broad.mit.edu	37	19	53959670	53959670	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:53959670G>A	ENST00000454407.1	+	0	2362							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		TTACAAATGTGAAGAATGTGA	0.428000													21	60					0	0	0.010504	0	0
BTNL3	10917	broad.mit.edu	37	5	180432492	180432492	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:180432492C>T	ENST00000342868.6	+	8	1205	c.1021C>T	c.(1021-1023)Cat>Tat	p.H341Y		NM_197975.2	NP_932079.1	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3	341	B30.2/SPRY.				lipid metabolic process	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(10)|prostate(2)|skin(1)	25	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			AGCAGGGAAACATTACTGGGA	0.502000													37	127					0	0	0.005524	0	0
IGSF10	285313	broad.mit.edu	37	3	151155254	151155254	+	Silent	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:151155254T>G	ENST00000282466.3	-	6	7094	c.7095A>C	c.(7093-7095)ccA>ccC	p.P2365P	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2365	Ig-like C2-type 10.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTTCAGGTGGTGGGTTACCAT	0.378000													26	47					0	0	0.007291	0	0
NOL8	55035	broad.mit.edu	37	9	95077282	95077282	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:95077282G>A	ENST00000545558.1	-	7	2117	c.1625C>T	c.(1624-1626)gCg>gTg	p.A542V	NOL8_ENST00000442668.2_Missense_Mutation_p.A542V|NOL8_ENST00000542053.1_Missense_Mutation_p.A474V|NOL8_ENST00000535387.1_Missense_Mutation_p.A542V|NOL8_ENST00000358855.4_Missense_Mutation_p.A474V			Q76FK4	NOL8_HUMAN	nucleolar protein 8	542					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						CACAATCTCCGCAGGACGAAT	0.507000													6	38					0	0	0.003080	0	0
KIF20A	10112	broad.mit.edu	37	5	137517384	137517384	+	Silent	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:137517384T>C	ENST00000394894.3	+	4	568	c.342T>C	c.(340-342)atT>atC	p.I114I	KIF20A_ENST00000508792.1_Silent_p.I96I	NM_005733.2	NP_005724.1	O95235	KI20A_HUMAN	kinesin family member 20A	114	Kinesin-motor.				cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|liver(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(1)	27			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AACGGGGAATTGGCCAAGCCA	0.478000													22	67					0	0	0.014323	0	0
DYRK3	8444	broad.mit.edu	37	1	206821372	206821372	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:206821372A>T	ENST00000367106.1	+	4	1242	c.769A>T	c.(769-771)Agt>Tgt	p.S257C	DYRK3_ENST00000367108.3_Missense_Mutation_p.S257C|DYRK3_ENST00000367109.2_Missense_Mutation_p.S277C|DYRK3_ENST00000489878.1_Intron			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	277	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CATGCTGGAAAGTTTCACATT	0.413000													21	91					0	0	0.014323	0	0
SAMD9	54809	broad.mit.edu	37	7	92734480	92734480	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:92734480G>A	ENST00000379958.2	-	3	1200	c.931C>T	c.(931-933)Cca>Tca	p.P311S		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	311						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GAGAACTGTGGAATAATGTCC	0.338000													14	33					0	0	0.016723	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961064	73961064	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:73961064C>T	ENST00000373468.1	-	3	3979	c.3328G>A	c.(3328-3330)Gaa>Aaa	p.E1110K	KIAA2022_ENST00000055682.5_Missense_Mutation_p.E1110K			Q5QGS0	K2022_HUMAN	KIAA2022	1110					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity	p.E1110K(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TTGATTTTTTCCACACTGTCC	0.443000													11	8					0	0	0.016723	0	0
PRPF3	9129	broad.mit.edu	37	1	150305460	150305460	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:150305460C>T	ENST00000324862.6	+	6	683	c.518C>T	c.(517-519)cCt>cTt	p.P173L	PRPF3_ENST00000543398.1_Missense_Mutation_p.P38L|PRPF3_ENST00000467329.1_3'UTR|PRPF3_ENST00000414970.2_Missense_Mutation_p.P124L	NM_004698.2	NP_004689.1	O43395	PRPF3_HUMAN	pre-mRNA processing factor 3	173					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		CCAAAGACTCCTTCTTCCTCC	0.443000													36	57					0	0	0.008740	0	0
ITGA9	3680	broad.mit.edu	37	3	37725427	37725427	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:37725427A>G	ENST00000264741.5	+	18	2244	c.1988A>G	c.(1987-1989)aAc>aGc	p.N663S		NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	663					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TCTATCTCCAACCTCGGAGAT	0.458000													16	40					0	0	0.004007	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3394464	3394464	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:3394464G>A	ENST00000378378.4	+	11	1904	c.1499G>A	c.(1498-1500)cGg>cAg	p.R500Q	ARHGEF16_ENST00000378373.1_Missense_Mutation_p.R212Q|ARHGEF16_ENST00000378371.2_Missense_Mutation_p.R212Q|ARHGEF16_ENST00000413250.2_Missense_Mutation_p.R204Q	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	500					activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		TCTGCCTCCCGGTGGCTGCTG	0.612000													17	49					0	0	0.006122	0	0
CYP20A1	57404	broad.mit.edu	37	2	204116694	204116694	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:204116694C>T	ENST00000356079.4	+	4	417	c.294C>T	c.(292-294)gaC>gaT	p.D98D	CYP20A1_ENST00000429815.2_Silent_p.D98D|CYP20A1_ENST00000461371.1_3'UTR	NM_177538.2	NP_803882.1	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A, polypeptide 1	98						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	11						TTTCAGCGGACCCTTTTGAAA	0.363000													7	35					0	0	0.003080	0	0
GDF2	2658	broad.mit.edu	37	10	48413875	48413875	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:48413875G>A	ENST00000249598.1	-	2	1152	c.993C>T	c.(991-993)tcC>tcT	p.S331S		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	331					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						TTACCCGCAGGGAGGTCTTTT	0.612000													23	64					0	0	0.007291	0	0
NACA	4666	broad.mit.edu	37	12	57110203	57110203	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:57110203G>A	ENST00000454682.1	-	3	5392	c.5111C>T	c.(5110-5112)cCa>cTa	p.P1704L	NACA_ENST00000393891.4_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TTTGGTCTGTGGACCTTTCCG	0.527000			T	BCL6	NHL								77	210					0	0	0.014410	0	0
APOBEC3D	140564	broad.mit.edu	37	22	39421141	39421141	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:39421141C>T	ENST00000216099.7	+	3	684	c.277C>T	c.(277-279)Cct>Tct	p.P93S	APOBEC3D_ENST00000427494.2_Intron|APOBEC3D_ENST00000381568.4_Missense_Mutation_p.P93S	NM_152426.3	NP_689639.2	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	93					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)	11	Melanoma(58;0.04)					CAACCGACTGCCTGCTAACAG	0.547000													13	94					0	0	0.004007	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814685	106814685	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:106814685C>T	ENST00000407775.2	+	8	2625	c.2375C>T	c.(2374-2376)cCa>cTa	p.P792L	ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.P660L|ZFPM2_ENST00000378472.4_Missense_Mutation_p.P523L|ZFPM2_ENST00000517361.1_Missense_Mutation_p.P660L|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000521622.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	792					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GATATCTTTCCAGGAATTGTC	0.438000													9	9					0	0	0.006214	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203175	140203175	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:140203175G>A	ENST00000529859.1	+	1	1815	c.1815G>A	c.(1813-1815)tgG>tgA	p.W605*	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000378126.3_Nonsense_Mutation_p.W605*|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Nonsense_Mutation_p.W605*	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACGCTTGGCTTTCGTATG	0.662000													33	100					0	0	0.012213	0	0
SLC2A14	144195	broad.mit.edu	37	12	7970503	7970503	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:7970503G>A	ENST00000543909.1	-	15	2027	c.1268C>T	c.(1267-1269)cCa>cTa	p.P423L	SLC2A14_ENST00000431042.2_Missense_Mutation_p.P400L|SLC2A14_ENST00000542505.1_Missense_Mutation_p.P64L|SLC2A14_ENST00000535295.1_Missense_Mutation_p.P314L|SLC2A14_ENST00000539924.1_Missense_Mutation_p.P438L|SLC2A14_ENST00000396589.2_Missense_Mutation_p.P423L|SLC2A14_ENST00000340749.5_Missense_Mutation_p.P400L|SLC2A14_ENST00000542546.1_Missense_Mutation_p.P314L			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	423					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		CATCGCAGCTGGGCGGGGGCC	0.547000													15	47					0	0	0.006122	0	0
DBH	1621	broad.mit.edu	37	9	136501609	136501609	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:136501609G>A	ENST00000393056.2	+	1	128	c.116G>A	c.(115-117)gGc>gAc	p.G39D		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	39					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	GCACTGCAGGGCTCGGCTCCC	0.672000													13	52					0	0	0.013537	0	0
OR51F2	119694	broad.mit.edu	37	11	4842629	4842629	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:4842629C>T	ENST00000322110.5	+	1	79	c.14C>T	c.(13-15)tCc>tTc	p.S5F	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004753.1	NP_001004753.1	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F, member 2	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACTGAAACATCCCTGTCTTCT	0.408000													18	78					0	0	0.010504	0	0
CD84	8832	broad.mit.edu	37	1	160523735	160523735	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:160523735T>C	ENST00000368054.3	-	3	625	c.590A>G	c.(589-591)aAc>aGc	p.N197S	CD84_ENST00000534968.1_Missense_Mutation_p.N83S|RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000368051.3_Missense_Mutation_p.N197S|CD84_ENST00000368047.3_5'UTR|CD84_ENST00000368048.3_Missense_Mutation_p.N197S|CD84_ENST00000311224.4_Missense_Mutation_p.N197S	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	197	Ig-like C2-type.				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GCTGACAGGGTTCTGGGCTGT	0.527000													10	37					0	0	0.006214	0	0
SSPO	23145	broad.mit.edu	37	7	149500848	149500848	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:149500848C>T	ENST00000378016.2	+	0	8166							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGCCTGGTCCTCCTGGGCTC	0.687000													6	10					0	0	0.001168	0	0
LMO3	55885	broad.mit.edu	37	12	16753761	16753761	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:16753761C>T	ENST00000320122.6	-	2	556	c.34G>A	c.(34-36)Ggt>Agt	p.G12S	LMO3_ENST00000537304.1_Missense_Mutation_p.G12S|LMO3_ENST00000354662.1_Missense_Mutation_p.G12S|LMO3_ENST00000534946.1_Missense_Mutation_p.G12S|LMO3_ENST00000447609.1_Missense_Mutation_p.G12S|LMO3_ENST00000261169.6_Missense_Mutation_p.G23S|LMO3_ENST00000535535.1_Missense_Mutation_p.G12S|LMO3_ENST00000441439.2_Missense_Mutation_p.G12S|LMO3_ENST00000541846.1_Missense_Mutation_p.G12S|LMO3_ENST00000541295.1_Missense_Mutation_p.G30S|LMO3_ENST00000540848.1_Missense_Mutation_p.G12S|LMO3_ENST00000537568.1_5'UTR|LMO3_ENST00000540445.1_Missense_Mutation_p.G12S	NM_001243611.1	NP_001230540.1	Q8TAP4	LMO3_HUMAN	LIM domain only 3 (rhombotin-like 2)	12	LIM zinc-binding 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		zinc ion binding			endometrium(2)|large_intestine(2)|skin(1)	5		Hepatocellular(102;0.244)				CCAGCACAACCTTTCGGCTTG	0.468000													9	26					0	0	0.010729	0	0
MUC16	94025	broad.mit.edu	37	19	9046923	9046923	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:9046923C>T	ENST00000397910.4	-	5	34911	c.34708G>A	c.(34708-34710)Gaa>Aaa	p.E11570K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11572	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTCTGGTTCATATGGGGTC	0.502000													16	21					0	0	0.008871	0	0
HELLS	3070	broad.mit.edu	37	10	96313987	96313987	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:96313987G>A	ENST00000348459.5	+	3	363	c.258G>A	c.(256-258)atG>atA	p.M86I	HELLS_ENST00000394036.1_Missense_Mutation_p.M86I|HELLS_ENST00000394044.1_Missense_Mutation_p.M86I|HELLS_ENST00000371332.4_Missense_Mutation_p.M86I|HELLS_ENST00000239026.6_Missense_Mutation_p.M86I|HELLS_ENST00000462057.1_3'UTR|HELLS_ENST00000394045.1_Missense_Mutation_p.M86I	NM_018063.3	NP_060533.2	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	86					cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		TGACGAAAATGGAACAGCAAC	0.303000													24	75					0	0	0.004656	0	0
MBL2	4153	broad.mit.edu	37	10	54530513	54530513	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:54530513C>T	ENST00000373968.3	-	2	285	c.221G>A	c.(220-222)gGa>gAa	p.G74E	MBL2_ENST00000493043.1_5'UTR	NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	74	Collagen-like.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						CCCCAACTTTCCAGGGGGGCC	0.522000													24	82					0	0	0.004656	0	0
UGT1A1	54658	broad.mit.edu	37	2	234676526	234676526	+	Missense_Mutation	SNP	C	C	T	rs144978321		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:234676526C>T	ENST00000360418.3	+	3	1028	c.1028C>T	c.(1027-1029)tCg>tTg	p.S343L	UGT1A1_ENST00000305208.5_Missense_Mutation_p.S343L|UGT1A6_ENST00000373424.1_Missense_Mutation_p.S75L|UGT1A7_ENST00000373426.3_Missense_Mutation_p.S340L|UGT1A10_ENST00000373445.1_Missense_Mutation_p.S340L|UGT1A8_ENST00000373450.4_Missense_Mutation_p.S340L|UGT1A9_ENST00000354728.4_Missense_Mutation_p.S340L|UGT1A10_ENST00000344644.5_Missense_Mutation_p.S340L|UGT1A6_ENST00000305139.6_Missense_Mutation_p.S342L|UGT1A3_ENST00000482026.1_Missense_Mutation_p.S344L|UGT1A6_ENST00000406651.1_Missense_Mutation_p.S75L|UGT1A4_ENST00000373409.3_Missense_Mutation_p.S344L|UGT1A5_ENST00000373414.3_Missense_Mutation_p.S344L			P22309	UD11_HUMAN		343					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	ACCCGACCATCGAATCTTGCG	0.448000													29	111					0	0	0.012213	0	0
RAD17	5884	broad.mit.edu	37	5	68689179	68689179	+	Splice_Site	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:68689179A>T	ENST00000509734.1	+	14	1986		c.e14-1		RAD17_ENST00000345306.6_Splice_Site|RAD17_ENST00000358030.2_Splice_Site|RAD17_ENST00000354312.3_Splice_Site|RAD17_ENST00000354868.5_Splice_Site|RAD17_ENST00000361732.2_Splice_Site|RAD17_ENST00000380774.3_Splice_Site|RAD17_ENST00000504177.1_Intron|RAD17_ENST00000305138.4_Splice_Site|RAD17_ENST00000282891.6_Splice_Site|RAD17_ENST00000521422.1_Splice_Site			O75943	RAD17_HUMAN	RAD17 homolog (S. pombe)						cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding						Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		TTCTTTTTATAGGAGGTAGTA	0.294000								Other conserved DNA damage response genes					14	45					0	0	0.004007	0	0
KIAA1109	84162	broad.mit.edu	37	4	123097030	123097030	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:123097030C>T	ENST00000264501.4	+	6	692	c.319C>T	c.(319-321)Cgg>Tgg	p.R107W	KIAA1109_ENST00000388738.3_Missense_Mutation_p.R107W|KIAA1109_ENST00000455637.1_Missense_Mutation_p.R107W			Q2LD37	K1109_HUMAN	KIAA1109	107					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CATCATTTTTCGGTGGTGGAA	0.274000													7	13					0	0	0.003080	0	0
OR4D5	219875	broad.mit.edu	37	11	123810592	123810592	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:123810592C>T	ENST00000307033.2	+	1	343	c.269C>T	c.(268-270)cCt>cTt	p.P90L		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	90					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TCAGGCAACCCTACCATTTCC	0.473000													28	34					0	0	0.004656	0	0
KIAA1377	57562	broad.mit.edu	37	11	101828931	101828931	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:101828931C>T	ENST00000263468.8	+	5	809	c.539C>T	c.(538-540)tCa>tTa	p.S180L	KIAA1377_ENST00000537689.1_5'UTR	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	180							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TCCGCATTATCAAAAAATGAT	0.328000													67	162					0	0	0.014410	0	0
IGHG3	3502	broad.mit.edu	37	14	106236004	106236004	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:106236004G>A	ENST00000390551.2	-	0	799																											CTTTGGTTTTGGAGATGGTTT	0.612000													75	207					0	0	0.014410	0	0
CEP44	80817	broad.mit.edu	37	4	175223258	175223258	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:175223258A>T	ENST00000503780.1	+	4	572	c.158A>T	c.(157-159)tAt>tTt	p.Y53F	CEP44_ENST00000426172.1_Missense_Mutation_p.Y53F|CEP44_ENST00000296519.4_Missense_Mutation_p.Y53F|CEP44_ENST00000457424.2_Missense_Mutation_p.Y53F	NM_001040157.2	NP_001035247.1	Q9C0F1	CEP44_HUMAN	centrosomal protein 44kDa	53						centrosome|midbody|spindle pole				endometrium(2)|large_intestine(4)|lung(5)|stomach(1)	12						TACTCACCTTATGTAACAGAA	0.328000													10	30					0	0	0.006214	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62856333	62856333	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:62856333G>A	ENST00000584306.1	-	11	4461	c.3931C>T	c.(3931-3933)Cgc>Tgc	p.R1311C	LRRC37A3_ENST00000400877.3_Missense_Mutation_p.R349C|LRRC37A3_ENST00000334962.5_Missense_Mutation_p.R288C|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.R1311C|LRRC37A3_ENST00000339474.5_Missense_Mutation_p.R429C	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1311						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						ATGCGGGAGCGAGTTTTGTGA	0.413000													230	151					0	0	0.014410	0	0
DSCAM	1826	broad.mit.edu	37	21	41447102	41447102	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:41447102C>T	ENST00000400454.1	-	27	5227	c.4750G>A	c.(4750-4752)Gaa>Aaa	p.E1584K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1584					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGCCCTTCTTCGTTTTGGACA	0.527000													14	45					0	0	0.020292	0	0
SLC2A14	144195	broad.mit.edu	37	12	7970504	7970504	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:7970504G>A	ENST00000543909.1	-	15	2026	c.1267C>T	c.(1267-1269)Cca>Tca	p.P423S	SLC2A14_ENST00000431042.2_Missense_Mutation_p.P400S|SLC2A14_ENST00000542505.1_Missense_Mutation_p.P64S|SLC2A14_ENST00000535295.1_Missense_Mutation_p.P314S|SLC2A14_ENST00000539924.1_Missense_Mutation_p.P438S|SLC2A14_ENST00000396589.2_Missense_Mutation_p.P423S|SLC2A14_ENST00000340749.5_Missense_Mutation_p.P400S|SLC2A14_ENST00000542546.1_Missense_Mutation_p.P314S			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	423					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		ATCGCAGCTGGGCGGGGGCCC	0.547000													15	48					0	0	0.006122	0	0
GRIK1	2897	broad.mit.edu	37	21	31062114	31062114	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:31062114C>T	ENST00000399914.1	-	3	999	c.478G>A	c.(478-480)Gcg>Acg	p.A160T	GRIK1_ENST00000535441.1_Missense_Mutation_p.A160T|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000327783.4_Missense_Mutation_p.A160T|GRIK1_ENST00000399913.1_Missense_Mutation_p.A160T|GRIK1_ENST00000399907.1_Missense_Mutation_p.A160T|GRIK1_ENST00000309434.7_Missense_Mutation_p.A160T|GRIK1_ENST00000399909.1_Missense_Mutation_p.A160T|GRIK1_ENST00000389124.2_Missense_Mutation_p.A160T|GRIK1_ENST00000389125.3_Missense_Mutation_p.A160T			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	160					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TCCAGGATCGCCCTGCTGATA	0.488000													36	66					0	0	0.019004	0	0
LIG3	3980	broad.mit.edu	37	17	33316651	33316651	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:33316651C>T	ENST00000378526.4	+	4	991	c.858C>T	c.(856-858)atC>atT	p.I286I	LIG3_ENST00000262327.5_Silent_p.I286I	NM_013975.3	NP_039269.2	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent	286					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			endometrium(4)|large_intestine(8)|lung(9)|ovary(3)|pancreas(2)|prostate(1)|skin(3)|stomach(1)	31		Ovarian(249;0.17)			Bleomycin(DB00290)	CCCAGATCATCCAGGACTTCC	0.547000								Other BER factors					23	105					0	0	0.016522	0	0
B3GNT2	10678	broad.mit.edu	37	2	62450312	62450312	+	Silent	SNP	G	G	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:62450312G>C	ENST00000301998.4	+	2	1209	c.957G>C	c.(955-957)ctG>ctC	p.L319L	B3GNT2_ENST00000405767.1_Silent_p.L319L	NM_006577.5	NP_006568.2	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	319						Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)	18	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			CCCTGAGGCTGTACCATATCA	0.532000													27	57					0	0	0.006320	0	0
CACNA1E	777	broad.mit.edu	37	1	181701835	181701835	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:181701835G>A	ENST00000526775.1	+	19	2721	c.2556G>A	c.(2554-2556)agG>agA	p.R852R	CACNA1E_ENST00000367567.4_Silent_p.R478R|CACNA1E_ENST00000357570.5_Silent_p.R822R|CACNA1E_ENST00000360108.3_Silent_p.R852R|CACNA1E_ENST00000358338.5_Silent_p.R803R|CACNA1E_ENST00000367573.2_Silent_p.R871R|CACNA1E_ENST00000367570.1_Silent_p.R871R	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	871					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ACAACCAGAGGACCCCTTTGT	0.672000													7	25					0	0	0.003080	0	0
GPR97	222487	broad.mit.edu	37	16	57718363	57718363	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:57718363C>T	ENST00000333493.4	+	10	1385	c.1224C>T	c.(1222-1224)atC>atT	p.I408I	GPR97_ENST00000327655.6_Silent_p.I198I|RP11-405F3.4_ENST00000563062.1_RNA|GPR97_ENST00000450388.3_Silent_p.I288I	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	408					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TCTACACCATCCGTGATAGGG	0.627000													11	36					0	0	0.010729	0	0
NAF1	92345	broad.mit.edu	37	4	164050415	164050415	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:164050415G>A	ENST00000274054.2	-	8	1312	c.1119C>T	c.(1117-1119)ttC>ttT	p.F373F	NAF1_ENST00000509434.1_Intron|NAF1_ENST00000422287.2_Intron	NM_138386.2	NP_612395.2	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 ribonucleoprotein	373					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding	p.F373L(1)		NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(10)|ovary(2)	21	all_hematologic(180;0.166)	Prostate(90;0.109)				ATCCTCGTGTGAATTCTCTGT	0.448000													22	50					0	0	0.014323	0	0
CD163	9332	broad.mit.edu	37	12	7640647	7640647	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:7640647G>A	ENST00000359156.4	-	7	1659	c.1457C>T	c.(1456-1458)cCc>cTc	p.P486L	CD163_ENST00000541972.1_Missense_Mutation_p.P474L|CD163_ENST00000396620.3_Missense_Mutation_p.P486L|CD163_ENST00000432237.2_Missense_Mutation_p.P486L	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	486	SRCR 5.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						TCCAGAACAGGGAATGTCCCC	0.468000													8	11					0	0	0.006214	0	0
IRF2	3660	broad.mit.edu	37	4	185309930	185309930	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:185309930G>A	ENST00000393593.3	-	9	1239	c.1032C>T	c.(1030-1032)gcC>gcT	p.A344A		NM_002199.3	NP_002190.2	P14316	IRF2_HUMAN	interferon regulatory factor 2	344					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	22		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		TCTTGACGCGGGCCTGGGTGA	0.527000													30	84					0	0	0.010818	0	0
LILRA2	11027	broad.mit.edu	37	19	55085963	55085963	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:55085963G>A	ENST00000251377.3	+	4	399	c.266G>A	c.(265-267)tGg>tAg	p.W89*	LILRA2_ENST00000495786.1_3'UTR|LILRA2_ENST00000391738.3_Nonsense_Mutation_p.W89*|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000251376.3_Nonsense_Mutation_p.W89*|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000391737.1_Nonsense_Mutation_p.W77*|LILRB1_ENST00000418536.2_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		TCCATCACCTGGGAACACGCA	0.527000													21	56					0	0	0.016522	0	0
UGT1A4	54657	broad.mit.edu	37	2	234627728	234627728	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:234627728G>A	ENST00000373409.3	+	1	305	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A5_ENST00000373414.3_Intron	NM_007120.2	NP_009051.1														autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	26		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)		GACCCAGAAGGAATTTGATCG	0.453000													25	34					0	0	0.018920	0	0
MYBPH	4608	broad.mit.edu	37	1	203140628	203140628	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:203140628C>T	ENST00000255416.4	-	5	733	c.676G>A	c.(676-678)Gac>Aac	p.D226N		NM_004997.2	NP_004988.2	Q13203	MYBPH_HUMAN	myosin binding protein H	226	Ig-like C2-type 1.				cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle			endometrium(5)|large_intestine(6)|lung(7)|skin(1)|urinary_tract(1)	20			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		GAGTCCTGGTCCCCGGTGCGC	0.667000													21	18					0	0	0.021523	0	0
EIF3F	8665	broad.mit.edu	37	11	8008884	8008884	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:8008884C>T	ENST00000537635.1	+	1	448	c.30C>T	c.(28-30)tcC>tcT	p.S10S	EIF3F_ENST00000309828.4_5'UTR|EIF3F_ENST00000533626.1_5'UTR			O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3, subunit F	0						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)	13				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTTCCGCCTCCTTCTTTCTCG	0.567000											OREG0020726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	72	153					0	0	0.014410	0	0
CCBL1	883	broad.mit.edu	37	9	131600580	131600580	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:131600580G>A	ENST00000436267.2	-	6	699	c.550C>T	c.(550-552)Ccg>Tcg	p.P184S	CCBL1_ENST00000302586.3_Missense_Mutation_p.P90S|CCBL1_ENST00000320665.6_Intron|CCBL1_ENST00000483599.1_Intron			Q16773	KAT1_HUMAN	cysteine conjugate-beta lyase, cytoplasmic	90					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)	18					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	TTCCTGAGCGGGTCTATCTCC	0.582000													12	35					0	0	0.013537	0	0
TTLL8	164714	broad.mit.edu	37	22	50484295	50484295	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:50484295C>T	ENST00000266182.6	-	5	497	c.498G>A	c.(496-498)caG>caA	p.Q166Q	TTLL8_ENST00000440475.1_Silent_p.Q166Q					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CCAGGAACTCCTGCTGCTCAC	0.622000													5	6					0	0	0.001168	0	0
FRAS1	80144	broad.mit.edu	37	4	79188573	79188573	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:79188573T>C	ENST00000264895.6	+	9	1408	c.968T>C	c.(967-969)gTg>gCg	p.V323A	FRAS1_ENST00000325942.6_Missense_Mutation_p.V323A|FRAS1_ENST00000264899.6_Missense_Mutation_p.V323A	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	323	VWFC 5.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGTGCCAAAGTGGAGTGTGCC	0.547000													5	18					0	0	0.014758	0	0
CDC42EP2	10435	broad.mit.edu	37	11	65088540	65088540	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:65088540C>T	ENST00000544348.1	+	2	777	c.171C>T	c.(169-171)ttC>ttT	p.F57F	CDC42EP2_ENST00000279249.2_Silent_p.F57F|CDC42EP2_ENST00000533419.1_Silent_p.F57F			O14613	BORG1_HUMAN	CDC42 effector protein (Rho GTPase binding) 2	57					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity			lung(1)	1						ACATCTCCTTCCTGCAGGGCA	0.627000													23	62					0	0	0.004656	0	0
TIMP3	7078	broad.mit.edu	37	22	33253291	33253291	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:33253291C>T	ENST00000266085.6	+	3	561	c.260C>T	c.(259-261)tCc>tTc	p.S87F	SYN3_ENST00000358763.2_Intron|SYN3_ENST00000332840.5_Intron	NM_000362.4	NP_000353.1	P35625	TIMP3_HUMAN	TIMP metallopeptidase inhibitor 3	87	NTR.				negative regulation of membrane protein ectodomain proteolysis|visual perception		metal ion binding|metalloendopeptidase inhibitor activity|protein binding			endometrium(2)|large_intestine(3)|lung(1)|urinary_tract(1)	7						ACGGAAGCTTCCGAGAGTCTC	0.512000													25	84					0	0	0.010818	0	0
VTCN1	79679	broad.mit.edu	37	1	117695749	117695749	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:117695749C>T	ENST00000369458.3	-	4	766	c.688G>A	c.(688-690)Gac>Aac	p.D230N	VTCN1_ENST00000328189.3_Missense_Mutation_p.D114N|VTCN1_ENST00000539893.1_Missense_Mutation_p.D135N|VTCN1_ENST00000359008.4_Missense_Mutation_p.D233N	NM_024626.3	NP_078902.2	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation inhibitor 1	230	Ig-like V-type 2.					integral to membrane|plasma membrane				large_intestine(7)|lung(4)|upper_aerodigestive_tract(1)	12	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		TTGGCAATGTCATTTTCAATC	0.388000													18	58					0	0	0.016522	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881744	228881744	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:228881744G>A	ENST00000392056.3	-	7	3872	c.3826C>T	c.(3826-3828)Ccg>Tcg	p.P1276S	SPHKAP_ENST00000344657.5_Missense_Mutation_p.P1276S	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1276						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTACTGACCGGCTGCACGCTT	0.507000													19	49					0	0	0.012319	0	0
CCDC83	220047	broad.mit.edu	37	11	85610023	85610023	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:85610023C>T	ENST00000280245.4	+	7	1149	c.637C>T	c.(637-639)Cta>Tta	p.L213L	CCDC83_ENST00000529676.2_3'UTR|CCDC83_ENST00000342404.3_Silent_p.L213L|CCDC83_ENST00000376067.1_Silent_p.L114L	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	213										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				GGGCAGTTATCTAGAGATCTG	0.343000													13	32					0	0	0.004007	0	0
SPACA1	81833	broad.mit.edu	37	6	88757817	88757817	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:88757817C>T	ENST00000237201.1	+	1	311	c.194C>T	c.(193-195)cCt>cTt	p.P65L		NM_030960.2	NP_112222.1	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1	65						integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	20		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		TACGCTCCGCCTGAAACCGAG	0.642000													4	11					0	0	0.009096	0	0
LPIN3	64900	broad.mit.edu	37	20	39986017	39986017	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:39986017C>T	ENST00000373257.3	+	16	2060	c.1969C>T	c.(1969-1971)Cat>Tat	p.H657Y		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	657	C-LIP.				fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				TGCTCTGGGCCATATCCTGCC	0.612000													19	60					0	0	0.010504	0	0
MYLK	4638	broad.mit.edu	37	3	123452773	123452773	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:123452773C>T	ENST00000360772.3	-	11	1448	c.1070G>A	c.(1069-1071)aGa>aAa	p.R357K	MYLK_ENST00000360304.3_Missense_Mutation_p.R357K|MYLK_ENST00000346322.5_Missense_Mutation_p.R357K|MYLK_ENST00000359169.1_Missense_Mutation_p.R357K|MYLK_ENST00000475616.1_Missense_Mutation_p.R357K			Q15746	MYLK_HUMAN	myosin light chain kinase	357					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCCTGGTGCTCTTGGTTCCGG	0.647000													40	108					0	0	0.009718	0	0
BCAN	63827	broad.mit.edu	37	1	156621324	156621324	+	Silent	SNP	C	C	T	rs150989682	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:156621324C>T	ENST00000329117.4	+	7	1476	c.1140C>T	c.(1138-1140)atC>atT	p.I380I	BCAN_ENST00000361588.5_Silent_p.I380I|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	380					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding	p.I380M(1)		cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TAGAGGCTATCGTCACAGTGA	0.587000													34	27					0	0	0.012213	0	0
NPAT	4863	broad.mit.edu	37	11	108062855	108062855	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:108062855A>T	ENST00000278612.8	-	4	385	c.280T>A	c.(280-282)Tct>Act	p.S94T		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	94	Interaction with MIZF.				positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		CTGATCTGAGAAAGTGTATGG	0.333000													20	61					0	0	0.018920	0	0
CBLN4	140689	broad.mit.edu	37	20	54573646	54573646	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:54573646G>A	ENST00000064571.2	-	3	1873	c.573C>T	c.(571-573)tcC>tcT	p.S191S		NM_080617.4	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	191	C1q.					cell junction|extracellular region|synapse				endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			CAGAAAACGTGGAATACTGCC	0.453000													16	36					0	0	0.006122	0	0
COL4A3	1285	broad.mit.edu	37	2	228137729	228137729	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:228137729G>A	ENST00000396578.3	+	26	1985	c.1823G>A	c.(1822-1824)gGa>gAa	p.G608E	AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000396588.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	608	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGGTCCCCAGGACCTGCAGGA	0.617000													19	40					0	0	0.007413	0	0
LRWD1	222229	broad.mit.edu	37	7	102106487	102106487	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:102106487C>T	ENST00000292616.5	+	2	456	c.304C>T	c.(304-306)Ccc>Tcc	p.P102S		NM_152892.1	NP_690852.1	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain containing 1	102					chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|stomach(2)	20						GGAGGGCAACCCCTTCCTGAC	0.622000													15	24					0	0	0.020292	0	0
EHBP1	23301	broad.mit.edu	37	2	63085637	63085637	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:63085637C>T	ENST00000263991.5	+	8	1213	c.731C>T	c.(730-732)tCc>tTc	p.S244F	EHBP1_ENST00000431489.1_Intron|EHBP1_ENST00000405015.3_Intron|EHBP1_ENST00000354487.3_Intron|EHBP1_ENST00000405289.1_Intron	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	244						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TCAGCCAGTTCCTCTGAAGGT	0.408000													11	40					0	0	0.010729	0	0
SEC16A	9919	broad.mit.edu	37	9	139371356	139371356	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:139371356G>A	ENST00000313050.7	-	1	785	c.712C>T	c.(712-714)Ccc>Tcc	p.P238S	SEC16A_ENST00000431893.2_Missense_Mutation_p.P60S|SEC16A_ENST00000371706.3_Missense_Mutation_p.P60S|SEC16A_ENST00000290037.6_Missense_Mutation_p.P60S	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	60					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		ACCCCGCTGGGAACAGGTCCT	0.657000													7	23					0	0	0.003080	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310133	57310133	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:57310133G>A	ENST00000457912.1	+	2	72	c.72G>A	c.(70-72)ggG>ggA	p.G24G	SMTNL1_ENST00000527972.1_Silent_p.G6G|SMTNL1_ENST00000399154.2_Silent_p.G6G			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	6										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						AGAAGGAAGGGAAGCTCTCTG	0.597000													6	26					0	0	0.001984	0	0
GTF3C2	2976	broad.mit.edu	37	2	27558792	27558792	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:27558792G>A	ENST00000359541.2	-	9	1888	c.1459C>T	c.(1459-1461)Cct>Tct	p.P487S	AC109828.1_ENST00000416453.2_RNA|AC109828.1_ENST00000585326.1_RNA|GTF3C2_ENST00000264720.3_Missense_Mutation_p.P487S			Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide 2, beta 110kDa	487						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCTTCCGAGGGGTGCCTGGA	0.552000													9	29					0	0	0.008291	0	0
OR2T4	127074	broad.mit.edu	37	1	248525725	248525725	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:248525725C>T	ENST00000366475.1	+	1	843	c.843C>T	c.(841-843)atC>atT	p.I281I		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGTGGTCATCCTCTTCTATG	0.542000													72	83					0	0	0.014410	0	0
NLRP9	338321	broad.mit.edu	37	19	56223890	56223890	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:56223890C>T	ENST00000332836.2	-	7	2595	c.2568G>A	c.(2566-2568)ggG>ggA	p.G856G		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	856						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TCTTCAGTTTCCCATTGCAAA	0.448000													11	41					0	0	0.010729	0	0
XIST	7503	broad.mit.edu	37	X	73068291	73068291	+	RNA	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:73068291G>A	ENST00000429829.1	-	0	4297					NR_001564.2																						TCCCCTGCTGGAATACAAAGG	0.433000													8	9					0	0	0.003080	0	0
SPANXD	64648	broad.mit.edu	37	X	140785720	140785720	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:140785720C>T	ENST00000370515.3	-	2	529	c.196G>A	c.(196-198)Gaa>Aaa	p.E66K		NM_032417.2|NM_145665.1	NP_115793.1|NP_663698.1			SPANX family, member D											breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	9	Acute lymphoblastic leukemia(192;7.65e-05)					TTCACCAGTTCCTCTGGAGAT	0.458000													113	80					0	0	0.014410	0	0
ADD2	119	broad.mit.edu	37	2	70933534	70933534	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:70933534C>T	ENST00000264436.3	-	3	451	c.7G>A	c.(7-9)Gaa>Aaa	p.E3K	ADD2_ENST00000355733.3_Missense_Mutation_p.E3K|ADD2_ENST00000407644.2_Missense_Mutation_p.E3K|ADD2_ENST00000413157.2_Missense_Mutation_p.E3K|ADD2_ENST00000430656.1_Missense_Mutation_p.E19K	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	3					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						ACCGTCTCTTCGCTCATTTTC	0.617000													25	62					0	0	0.006320	0	0
VCAM1	7412	broad.mit.edu	37	1	101186048	101186048	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:101186048C>T	ENST00000294728.2	+	2	182	c.81C>T	c.(79-81)atC>atT	p.I27I	VCAM1_ENST00000370119.4_Silent_p.I27I|VCAM1_ENST00000370115.1_Silent_p.I27I|VCAM1_ENST00000347652.2_Silent_p.I27I	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	27	Ig-like C2-type 1.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding	p.I27M(1)		central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CTTTTAAAATCGAGACCACCC	0.408000													8	24					0	0	0.008291	0	0
KLHL14	57565	broad.mit.edu	37	18	30322008	30322008	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:30322008G>A	ENST00000359358.4	-	3	1390	c.952C>T	c.(952-954)Cgc>Tgc	p.R318C	KLHL14_ENST00000358095.4_Missense_Mutation_p.R318C	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	318						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						TTGTTAGAGCGAATTCTTCAC	0.428000													14	31					0	0	0.004007	0	0
ZBTB8A	653121	broad.mit.edu	37	1	33060732	33060732	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:33060732C>T	ENST00000373510.4	+	4	1130	c.901C>T	c.(901-903)Ctt>Ttt	p.L301F	RP1-27O5.3_ENST00000480336.1_3'UTR|ZBTB8A_ENST00000316459.4_Missense_Mutation_p.L301F	NM_001040441.1	NP_001035531.1	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(2)|lung(2)|prostate(1)	7						AAAGCGCCACCTTCGTTGTCA	0.468000													15	62					0	0	0.003163	0	0
UGT1A6	54578	broad.mit.edu	37	2	234602064	234602064	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:234602064C>T	ENST00000305139.6	+	1	553	c.414C>T	c.(412-414)ttC>ttT	p.F138F	UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000480628.1_Intron	NM_001072.3	NP_001063.2														central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		CCCTGAACTTCTTTAAGGAGA	0.488000													14	52					0	0	0.003163	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175770	140175770	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:140175770G>A	ENST00000526136.1	+	1	1221	c.1221G>A	c.(1219-1221)ttG>ttA	p.L407L	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Silent_p.L407L|PCDHA2_ENST00000378132.1_Silent_p.L407L	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTACTCGTTGGTGCTGGACA	0.622000													157	187					0	0	0.014410	0	0
STON2	85439	broad.mit.edu	37	14	81862472	81862472	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:81862472C>T	ENST00000555447.1	-	4	551	c.139G>A	c.(139-141)Gag>Aag	p.E47K	STON2_ENST00000267540.2_Missense_Mutation_p.E47K	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	47					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GAGGAGCTCTCGGACTGGTCT	0.577000													19	40					0	0	0.007413	0	0
XK	7504	broad.mit.edu	37	X	37586969	37586969	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:37586969G>A	ENST00000378616.3	+	3	792	c.589G>A	c.(589-591)Gat>Aat	p.D197N	TM4SF2_ENST00000465127.1_Intron	NM_021083.2	NP_066569.1	P51811	XK_HUMAN	X-linked Kx blood group (McLeod syndrome)	197					amino acid transport	integral to membrane	protein binding|transporter activity			breast(1)|endometrium(4)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	15		all_lung(315;0.175)				AATCAAGTACGATGAGTATGA	0.478000													4	2					0	0	0.009096	0	0
AKAP9	10142	broad.mit.edu	37	7	91651606	91651606	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:91651606C>T	ENST00000359028.2	+	14	4153	c.3928C>T	c.(3928-3930)Cca>Tca	p.P1310S	AKAP9_ENST00000358100.2_Missense_Mutation_p.P1310S|AKAP9_ENST00000356239.3_Missense_Mutation_p.P1298S			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	1310					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGAAAACCTTCCAAAAGAGGA	0.338000			T	BRAF	papillary thyroid								18	57					0	0	0.014323	0	0
CYP2C8	1558	broad.mit.edu	37	10	96824697	96824697	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:96824697A>T	ENST00000371270.3	-	4	596	c.502T>A	c.(502-504)Ttc>Atc	p.F168I	CYP2C8_ENST00000535898.1_Missense_Mutation_p.F66I|CYP2C8_ENST00000539050.1_Missense_Mutation_p.F82I	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	168					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	CCCAGGATGAAAGTGGGATCA	0.308000													14	30					0	0	0.004990	0	0
OBP2A	29991	broad.mit.edu	37	9	138438731	138438731	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:138438731G>A	ENST00000539850.1	+	2	206	c.180G>A	c.(178-180)ggG>ggA	p.G60G	OBP2A_ENST00000342114.4_Intron|OBP2A_ENST00000371776.1_Silent_p.G60G|OBP2A_ENST00000340780.3_Silent_p.G60G			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	60					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		TGGGCGGTGGGAACTTGGAAG	0.632000													10	31					0	0	0.008291	0	0
USH2A	7399	broad.mit.edu	37	1	216017672	216017672	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:216017672C>T	ENST00000366943.2	-	46	9608	c.9222G>A	c.(9220-9222)ctG>ctA	p.L3074L	USH2A_ENST00000307340.3_Silent_p.L3074L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3074	Fibronectin type-III 17.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAGGTCTCTCAGAATAAACG	0.378000										HNSCC(13;0.011)			16	18					0	0	0.008871	0	0
PTPRN	5798	broad.mit.edu	37	2	220161981	220161981	+	Missense_Mutation	SNP	C	C	T	rs142270672		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:220161981C>T	ENST00000295718.2	-	14	2302	c.2062G>A	c.(2062-2064)Gac>Aac	p.D688N	PTPRN_ENST00000423636.2_Missense_Mutation_p.D598N|PTPRN_ENST00000409251.3_Missense_Mutation_p.D659N	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	688					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity	p.D688N(1)		breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GTGGAGATGTCCATGTTGGCT	0.657000													18	41					0	0	0.010504	0	0
PDHA2	5161	broad.mit.edu	37	4	96761632	96761632	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:96761632C>T	ENST00000295266.4	+	1	394	c.331C>T	c.(331-333)Cac>Tac	p.H111Y		NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2	111					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CCCCTCGGATCACGTCATTAC	0.527000													30	95					0	0	0.015359	0	0
LPHN3	23284	broad.mit.edu	37	4	62903526	62903526	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:62903526G>A	ENST00000512091.1	+	23	4212	c.3465G>A	c.(3463-3465)ggG>ggA	p.G1155G	LPHN3_ENST00000504896.1_Silent_p.G1155G|LPHN3_ENST00000545650.1_Silent_p.G1155G|LPHN3_ENST00000514591.1_Silent_p.G1155G|LPHN3_ENST00000514157.1_Silent_p.G1146G|LPHN3_ENST00000507625.1_Silent_p.G1214G|LPHN3_ENST00000506720.1_Silent_p.G1223G|LPHN3_ENST00000506700.1_Silent_p.G1146G|LPHN3_ENST00000511324.1_Silent_p.G1214G|LPHN3_ENST00000509896.1_Silent_p.G1223G|LPHN3_ENST00000506746.1_Silent_p.G1214G|LPHN3_ENST00000508946.1_Silent_p.G1155G|LPHN3_ENST00000514996.1_Silent_p.G1146G|LPHN3_ENST00000507164.1_Silent_p.G1214G|LPHN3_ENST00000508693.1_Silent_p.G1223G			Q9HAR2	LPHN3_HUMAN	latrophilin 3	1133					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TTGGTTCAGGGAAAACATCTG	0.403000													15	39					0	0	0.004990	0	0
ADH1C	126	broad.mit.edu	37	4	100266412	100266412	+	RNA	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:100266412T>A	ENST00000515683.1	-	0	622				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	AAGAGCGGGATGACTTTATCA	0.343000													5	11					0	0	0.001984	0	0
OR10G8	219869	broad.mit.edu	37	11	123900864	123900864	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:123900864G>A	ENST00000431524.1	+	1	568	c.535G>A	c.(535-537)Gat>Aat	p.D179N		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTATTTGTGTGATGCACCGCC	0.527000													30	62					0	0	0.006230	0	0
CDX4	1046	broad.mit.edu	37	X	72674248	72674248	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:72674248G>A	ENST00000373514.2	+	3	682	c.682G>A	c.(682-684)Gag>Aag	p.E228K		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	228						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					CAGAGCCAAGGAGAGAAAGAT	0.433000													7	1					0	0	0.003080	0	0
LAMA4	3910	broad.mit.edu	37	6	112471788	112471788	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:112471788C>T	ENST00000230538.7	-	17	2495	c.2098G>A	c.(2098-2100)Gga>Aga	p.G700R	LAMA4_ENST00000522006.1_Missense_Mutation_p.G693R|LAMA4_ENST00000424408.2_Missense_Mutation_p.G693R|LAMA4_ENST00000389463.4_Missense_Mutation_p.G693R	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	700	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GCTAGGGCTCCACCCACACGC	0.502000													35	50					0	0	0.017118	0	0
C15orf27	123591	broad.mit.edu	37	15	76430211	76430211	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:76430211C>T	ENST00000388942.3	+	3	478	c.202C>T	c.(202-204)Ctg>Ttg	p.L68L		NM_152335.2	NP_689548.2	Q2M3C6	CO027_HUMAN	chromosome 15 open reading frame 27	68						integral to membrane				endometrium(1)|large_intestine(1)|lung(10)|pancreas(1)	13						CCTGTCAAATCTGGACGAAGA	0.572000													19	51					0	0	0.012319	0	0
MKI67	4288	broad.mit.edu	37	10	129903931	129903931	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:129903931C>T	ENST00000368654.3	-	13	6548	c.6173G>A	c.(6172-6174)gGg>gAg	p.G2058E	MKI67_ENST00000368653.3_Missense_Mutation_p.G1698E	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2058	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CCTCTCCATCCCAGTTCCATA	0.512000													74	189					0	0	0.014410	0	0
ZNF438	220929	broad.mit.edu	37	10	31137869	31137869	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:31137869G>A	ENST00000538351.1	-	7	2072	c.1318C>T	c.(1318-1320)Cct>Tct	p.P440S	ZNF438_ENST00000452305.1_Missense_Mutation_p.P479S|ZNF438_ENST00000444692.2_Missense_Mutation_p.P479S|ZNF438_ENST00000413025.1_Missense_Mutation_p.P489S|ZNF438_ENST00000361310.3_Missense_Mutation_p.P489S|ZNF438_ENST00000442986.1_Missense_Mutation_p.P489S|ZNF438_ENST00000331737.6_Missense_Mutation_p.P479S|ZNF438_ENST00000375311.1_Missense_Mutation_p.P53S|ZNF438_ENST00000436087.2_Missense_Mutation_p.P489S	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	489					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				CTGGGCTTAGGGGAAGAGCTG	0.473000													42	99					0	0	0.007835	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561083	44561083	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:44561083C>T	ENST00000332567.4	-	1	905	c.553G>A	c.(553-555)Gag>Aag	p.E185K	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	185					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GCAGCGGGCTCAGGGCCCTCG	0.692000													23	41					0	0	0.016522	0	0
TXNDC16	57544	broad.mit.edu	37	14	52899126	52899126	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:52899126T>A	ENST00000281741.4	-	21	2745	c.2374A>T	c.(2374-2376)Att>Ttt	p.I792F		NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	792					cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					AGAGTTTCAATCGGTTCTTTT	0.363000													18	45					0	0	0.006122	0	0
HEATR5A	25938	broad.mit.edu	37	14	31852855	31852855	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:31852855G>A	ENST00000543095.2	-	10	1652	c.1468C>T	c.(1468-1470)Cgt>Tgt	p.R490C	HEATR5A_ENST00000439727.1_Missense_Mutation_p.R197C|HEATR5A_ENST00000389961.3_Missense_Mutation_p.R484C|HEATR5A_ENST00000404677.3_Missense_Mutation_p.R490C|HEATR5A_ENST00000439348.1_Missense_Mutation_p.R484C	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	484							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		TCAAGGCAACGATCCAAGAGT	0.468000													36	104					0	0	0.009718	0	0
AVPR1B	553	broad.mit.edu	37	1	206224806	206224806	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:206224806C>T	ENST00000367126.4	+	1	831	c.366C>T	c.(364-366)acC>acT	p.T122T		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	122					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	TTGCCTCCACCTACATGCTGC	0.642000													27	74					0	0	0.009535	0	0
KIF19	124602	broad.mit.edu	37	17	72346585	72346585	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:72346585G>A	ENST00000389916.4	+	11	1397	c.1259G>A	c.(1258-1260)gGa>gAa	p.G420E		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	420					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						GCTGGCATGGGACAGCTTCGG	0.642000													4	11					0	0	0.009096	0	0
LLGL1	3996	broad.mit.edu	37	17	18137373	18137373	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:18137373T>G	ENST00000316843.4	+	6	694	c.598T>G	c.(598-600)Tca>Gca	p.S200A		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	200					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					CCCCGTGGAGTCACTCCAGGG	0.632000													9	9					0	0	0.004482	0	0
SPANXN3	139067	broad.mit.edu	37	X	142596803	142596803	+	Silent	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:142596803T>C	ENST00000370503.2	-	2	350	c.267A>G	c.(265-267)gtA>gtG	p.V89V	GS1-256O22.5_ENST00000431432.1_RNA	NM_001009609.2	NP_001009609.1	Q5MJ09	SPXN3_HUMAN	SPANX family, member N3	89			V -> I (in dbSNP:rs5953851).							endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					CAGATAAGTCTACGCCTTCGT	0.438000													31	19					0	0	0.010818	0	0
WDR88	126248	broad.mit.edu	37	19	33639710	33639710	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:33639710C>T	ENST00000361680.2	+	5	651	c.573C>T	c.(571-573)tcC>tcT	p.S191S	WDR88_ENST00000592765.1_3'UTR|WDR88_ENST00000355868.3_Silent_p.S191S			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	191										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					TCATCGTCTCCTGTAAGTTTT	0.468000													28	104					0	0	0.006320	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35906721	35906721	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:35906721C>T	ENST00000325722.3	-	20	3123	c.2889G>A	c.(2887-2889)aaG>aaA	p.K963K	KIAA0319L_ENST00000485551.1_5'UTR|KIAA0319L_ENST00000373266.4_Silent_p.K400K	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	963						cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGCTTTTCCTCTTGGGTTTTC	0.552000													22	113					0	0	0.006320	0	0
TTN	7273	broad.mit.edu	37	2	179545055	179545055	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:179545055G>A	ENST00000589042.1	-	139	33568	c.33344C>T	c.(33343-33345)cCc>cTc	p.P11115L	TTN_ENST00000591111.1_Missense_Mutation_p.P10798L|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.P9871L|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10798	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGCTTCATGGGCACTTGAAA	0.393000													23	60					0	0	0.005443	0	0
TAS2R1	50834	broad.mit.edu	37	5	9630007	9630007	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:9630007G>A	ENST00000382492.2	-	1	456	c.138C>T	c.(136-138)ctC>ctT	p.L46L	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	46					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						AAGAAAGAAGGAGATCCAGCG	0.383000													11	39					0	0	0.013537	0	0
SLC17A3	10786	broad.mit.edu	37	6	25862158	25862158	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:25862158C>T	ENST00000397060.4	-	4	512	c.403G>A	c.(403-405)Gga>Aga	p.G135R	SLC17A3_ENST00000361703.6_Intron|SLC17A3_ENST00000360657.3_Intron	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	277					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						CCTACTCTTCCAGCCAGGTAT	0.483000													5	12					0	0	0.001168	0	0
CARD9	64170	broad.mit.edu	37	9	139265382	139265382	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:139265382C>T	ENST00000371732.5	-	4	703	c.538G>A	c.(538-540)Gag>Aag	p.E180K	CARD9_ENST00000315908.7_Missense_Mutation_p.E180K|CARD9_ENST00000371734.3_Missense_Mutation_p.E180K	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	180					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		TAGTTCTCCTCCTTGCAGCGC	0.682000													7	11					0	0	0.003080	0	0
RSPH4A	345895	broad.mit.edu	37	6	116938061	116938061	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:116938061C>T	ENST00000229554.5	+	1	412	c.275C>T	c.(274-276)tCc>tTc	p.S92F	RSPH4A_ENST00000368580.4_Missense_Mutation_p.S92F|RSPH4A_ENST00000368581.4_Missense_Mutation_p.S92F	NM_001010892.2	NP_001010892.1	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A (Chlamydomonas)	92					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke				breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GAGCCCTCTTCCTCTCCTTCT	0.632000									Kartagener syndrome				15	36					0	0	0.003163	0	0
HCN3	57657	broad.mit.edu	37	1	155257581	155257581	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:155257581A>G	ENST00000368358.3	+	8	1660	c.1652A>G	c.(1651-1653)aAt>aGt	p.N551S	HCN3_ENST00000496230.1_3'UTR	NM_020897.1	NP_065948.1	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	551						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGCAAGAAGAATTCCATACTG	0.512000													68	64					0	0	0.014410	0	0
NCOA6	23054	broad.mit.edu	37	20	33328820	33328820	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:33328820G>A	ENST00000374796.2	-	12	7810	c.5240C>T	c.(5239-5241)cCt>cTt	p.P1747L	NCOA6_ENST00000359003.2_Missense_Mutation_p.P1747L			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1747	EP300/CRSP3-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						AGACGTACAAGGAGGGGAAGG	0.542000													15	63					0	0	0.020292	0	0
VPS13B	157680	broad.mit.edu	37	8	100887878	100887878	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:100887878G>A	ENST00000358544.2	+	62	12164	c.12053G>A	c.(12052-12054)aGg>aAg	p.R4018K	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.R3993K	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	4018					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAAGCCCTGAGGAAAGGGTTT	0.443000													13	53					0	0	0.003163	0	0
WDR19	57728	broad.mit.edu	37	4	39276558	39276558	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:39276558G>A	ENST00000399820.3	+	33	3850	c.3696G>A	c.(3694-3696)aaG>aaA	p.K1232K	WDR19_ENST00000288634.7_Silent_p.K1072K	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1232					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						AATACAAAAAGAAGATCGAGG	0.443000													16	25					0	0	0.004007	0	0
FNDC3B	64778	broad.mit.edu	37	3	172061888	172061888	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:172061888C>T	ENST00000336824.4	+	19	2189	c.2090C>T	c.(2089-2091)tCg>tTg	p.S697L	FNDC3B_ENST00000416957.1_Missense_Mutation_p.S697L|FNDC3B_ENST00000415807.2_Missense_Mutation_p.S697L	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	697	Fibronectin type-III 5.					endoplasmic reticulum|integral to membrane		p.S697L(1)		breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		GTTCCTGCATCGGAAAGTGGC	0.493000													25	87					0	0	0.021523	0	0
ANK3	288	broad.mit.edu	37	10	61819137	61819137	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:61819137C>T	ENST00000280772.1	-	41	12838	c.12647G>A	c.(12646-12648)cGa>cAa	p.R4216Q	ANK3_ENST00000373827.2_Missense_Mutation_p.R1700Q|ANK3_ENST00000503366.1_Missense_Mutation_p.R1707Q|ANK3_ENST00000355288.2_Missense_Mutation_p.R840Q|RP11-388P9.2_ENST00000414383.1_RNA	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4216					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AGTTACTCTTCGAGCTTGAGC	0.408000													24	65					0	0	0.006320	0	0
EVI5L	115704	broad.mit.edu	37	19	7916645	7916645	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:7916645G>A	ENST00000270530.4	+	8	1172	c.976G>A	c.(976-978)Ggg>Agg	p.G326R	EVI5L_ENST00000538904.2_Missense_Mutation_p.G326R	NM_145245.3	NP_660288.1	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like	326						intracellular	protein binding|Rab GTPase activator activity			breast(1)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	12						GGACATGGAGGGGATGTCCCA	0.667000													5	15					0	0	0.014758	0	0
VCAM1	7412	broad.mit.edu	37	1	101186267	101186267	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:101186267A>G	ENST00000294728.2	+	2	401	c.300A>G	c.(298-300)gaA>gaG	p.E100E	VCAM1_ENST00000370119.4_Intron|VCAM1_ENST00000370115.1_Silent_p.E100E|VCAM1_ENST00000347652.2_Silent_p.E100E	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	100	Ig-like C2-type 1.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CAACTTGTGAATCTAGGAAAT	0.383000													7	7					0	0	0.001984	0	0
MYO7A	4647	broad.mit.edu	37	11	76885844	76885844	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:76885844G>A	ENST00000409709.3	+	17	2250	c.1978G>A	c.(1978-1980)Gga>Aga	p.G660R	MYO7A_ENST00000409619.2_Missense_Mutation_p.G649R|MYO7A_ENST00000458637.2_Missense_Mutation_p.G660R|MYO7A_ENST00000409893.1_Missense_Mutation_p.G660R	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	660	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCGGTACTCAGGAATGATGGA	0.632000													7	15					0	0	0.001984	0	0
HDGF	3068	broad.mit.edu	37	1	156714925	156714925	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:156714925G>A	ENST00000357325.5	-	3	492	c.178C>T	c.(178-180)Ccc>Tcc	p.P60S	HDGF_ENST00000368209.5_Missense_Mutation_p.P53S|HDGF_ENST00000537739.1_Missense_Mutation_p.P60S|HDGF_ENST00000465180.1_5'UTR|HDGF_ENST00000416666.2_Missense_Mutation_p.P28S|HDGF_ENST00000368206.5_Missense_Mutation_p.P76S	NM_004494.2	NP_004485.1	P51858	HDGF_HUMAN	hepatoma-derived growth factor	60	PWWP.				cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		AGGTCTTTGGGGCCCAGGAAT	0.587000													26	33					0	0	0.005443	0	0
ROBO2	6092	broad.mit.edu	37	3	75986676	75986676	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:75986676G>A	ENST00000487694.3	+	2	311	c.32G>A	c.(31-33)aGg>aAg	p.R11K		NM_001128929.2	NP_001122401.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	0					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GTCACTAGAAGGATGTGGACA	0.438000													3	15					0	0	0.009096	0	0
RNF17	56163	broad.mit.edu	37	13	25451191	25451191	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:25451191T>G	ENST00000255324.5	+	34	4692	c.4640T>G	c.(4639-4641)cTc>cGc	p.L1547R	RNF17_ENST00000339524.3_Missense_Mutation_p.L557R|RNF17_ENST00000381921.1_Missense_Mutation_p.L1505R	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1547					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		ATAAAGGTTCTCTTGGCAGGG	0.443000													15	39					0	0	0.010504	0	0
IHH	3549	broad.mit.edu	37	2	219920370	219920370	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:219920370G>A	ENST00000295731.5	-	3	794	c.795C>T	c.(793-795)ccC>ccT	p.P265P		NM_002181.3	NP_002172.2	Q14623	IHH_HUMAN	indian hedgehog	265					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCGGCGTGGGGGGTCCTGAG	0.647000													12	22					0	0	0.013537	0	0
HRG	3273	broad.mit.edu	37	3	186394924	186394924	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:186394924C>T	ENST00000232003.4	+	7	910	c.830C>T	c.(829-831)cCa>cTa	p.P277L		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	277	Pro-rich.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		ACCAAGCCTCCATTCAAGCCC	0.527000													22	77					0	0	0.014323	0	0
CILP2	148113	broad.mit.edu	37	19	19656395	19656395	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:19656395C>T	ENST00000586018.1	+	8	3161	c.3059C>T	c.(3058-3060)cCc>cTc	p.P1020L	CILP2_ENST00000291495.4_Missense_Mutation_p.P1014L			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1014						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						ACCATTATGCCCCAGGGCAGC	0.697000													6	7					0	0	0.001984	0	0
HMCN1	83872	broad.mit.edu	37	1	185976275	185976275	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:185976275C>T	ENST00000271588.4	+	30	4720	c.4491C>T	c.(4489-4491)ggC>ggT	p.G1497G	HMCN1_ENST00000367492.2_Silent_p.G1497G	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1497	Ig-like C2-type 12.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TATTTTTGGGCGATCCTAATG	0.353000													4	17					0	0	0.009096	0	0
NOS1	4842	broad.mit.edu	37	12	117768500	117768500	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:117768500G>A	ENST00000317775.6	-	2	1060	c.375C>T	c.(373-375)ccC>ccT	p.P125P	NOS1_ENST00000338101.4_Silent_p.P125P|NOS1_ENST00000344089.3_Silent_p.P125P	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	125	Interaction with NOSIP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GGGGACCCAGGGGCTGTGTCA	0.652000													18	61					0	0	0.006122	0	0
HYDIN	54768	broad.mit.edu	37	16	70852320	70852320	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:70852320C>T	ENST00000393567.2	-	84	14733	c.14583G>A	c.(14581-14583)tcG>tcA	p.S4861S		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	4861										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGAAGGTCACCGAGTAGGGCA	0.617000													7	17					0	0	0.008291	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20517359	20517359	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:20517359G>A	ENST00000202677.6	-	25	3497	c.3355C>T	c.(3355-3357)Cct>Tct	p.P1119S		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	1119					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						TGCAGTAAAGGAATCTCCTGG	0.458000													5	22					0	0	0.014758	0	0
FAM134C	162427	broad.mit.edu	37	17	40734029	40734029	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:40734029G>A	ENST00000309428.5	-	9	1262	c.1203C>T	c.(1201-1203)gtC>gtT	p.V401V	FAM134C_ENST00000585894.1_Silent_p.V304V|FAM134C_ENST00000543197.1_Silent_p.V206V	NM_178126.3	NP_835227.1	Q86VR2	F134C_HUMAN	family with sequence similarity 134, member C	401						integral to membrane				endometrium(1)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	11		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		TACCCTGGGAGACCAGGCTGG	0.652000													39	52					0	0	0.006230	0	0
SH3TC1	54436	broad.mit.edu	37	4	8229539	8229539	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:8229539C>T	ENST00000539824.1	+	12	2264	c.1890C>T	c.(1888-1890)ctC>ctT	p.L630L	SH3TC1_ENST00000245105.3_Silent_p.L706L			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	706							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						CCGCGTGGCTCTCAGACTGCT	0.652000													18	52					0	0	0.006122	0	0
IRF2BPL	64207	broad.mit.edu	37	14	77493062	77493062	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:77493062G>A	ENST00000238647.3	-	1	1972	c.1074C>T	c.(1072-1074)agC>agT	p.S358S		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	358						nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						GCAGGCTCTCGCTCAGCTCGG	0.682000													9	25					0	0	0.008291	0	0
ROS1	6098	broad.mit.edu	37	6	117709079	117709079	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:117709079G>A	ENST00000368508.3	-	13	2076	c.1878C>T	c.(1876-1878)ttC>ttT	p.F626F	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Silent_p.F621F	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	626	Fibronectin type-III 3.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTATGTTCAAGAAAATATGAG	0.453000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								31	49					0	0	0.010818	0	0
TLDC2	140711	broad.mit.edu	37	20	35507531	35507531	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:35507531C>T	ENST00000217320.3	+	3	321	c.277C>T	c.(277-279)Ctg>Ttg	p.L93L	TLDC2_ENST00000602922.1_Silent_p.L93L	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		CCTGCAGAGCCTGTACCGGCG	0.662000													19	72					0	0	0.008871	0	0
NCAPH2	29781	broad.mit.edu	37	22	50957150	50957150	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:50957150C>T	ENST00000395701.3	+	8	813	c.719C>T	c.(718-720)tCc>tTc	p.S240F	NCAPH2_ENST00000299821.11_Missense_Mutation_p.S240F|NCAPH2_ENST00000395698.3_Missense_Mutation_p.S240F|NCAPH2_ENST00000420993.2_Missense_Mutation_p.S240F			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2	240					chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CTCGGCTTCTCCCAGGAGCCA	0.642000													6	6					0	0	0.003080	0	0
F13B	2165	broad.mit.edu	37	1	197030188	197030188	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:197030188C>G	ENST00000367412.1	-	4	512	c.469G>C	c.(469-471)Gaa>Caa	p.E157Q		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	157	Sushi 3.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TTATATAATTCAGGAGCCAAA	0.269000													3	13					0	0	0.004672	0	0
TXK	7294	broad.mit.edu	37	4	48073661	48073661	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:48073661C>T	ENST00000264316.4	-	14	1473	c.1388G>A	c.(1387-1389)gGa>gAa	p.G463E	TXK_ENST00000507351.1_Missense_Mutation_p.G118E	NM_003328.2	NP_003319.2	P42681	TXK_HUMAN	TXK tyrosine kinase	463	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(2)	25						AGGCATTTTTCCTTCTGTAAA	0.383000													22	87					0	0	0.014323	0	0
C1orf173	127254	broad.mit.edu	37	1	75037636	75037636	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:75037636C>T	ENST00000326665.5	-	14	3976	c.3758G>A	c.(3757-3759)gGa>gAa	p.G1253E	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1253	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CCCCTCCAGTCCTGCGCAGGA	0.592000													24	67					0	0	0.016522	0	0
TRPM8	79054	broad.mit.edu	37	2	234858746	234858746	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:234858746G>A	ENST00000324695.4	+	9	1136	c.1096G>A	c.(1096-1098)Gtg>Atg	p.V366M	TRPM8_ENST00000433712.2_Missense_Mutation_p.V54M|AC005538.5_ENST00000455991.1_RNA	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	366						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	ACCCCGCACGGTGTCCCGGCT	0.557000													8	20					0	0	0.003080	0	0
ARFIP1	27236	broad.mit.edu	37	4	153802227	153802227	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:153802227T>C	ENST00000451320.2	+	6	688	c.524T>C	c.(523-525)aTt>aCt	p.I175T	ARFIP1_ENST00000405727.2_Missense_Mutation_p.I143T|ARFIP1_ENST00000356064.3_Missense_Mutation_p.I143T|ARFIP1_ENST00000511289.1_3'UTR|ARFIP1_ENST00000429148.2_Intron|ARFIP1_ENST00000353617.2_Missense_Mutation_p.I175T			P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	175	AH.				intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane			ARFIP1/FHDC1(2)	cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(180;0.093)					TATGAAAATATTTTAAAACTG	0.393000													7	24					0	0	0.003080	0	0
SMYD1	150572	broad.mit.edu	37	2	88409921	88409921	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:88409921G>A	ENST00000419482.2	+	10	1448	c.1363G>A	c.(1363-1365)Gaa>Aaa	p.E455K	SMYD1_ENST00000444564.2_Missense_Mutation_p.E442K|SMYD1_ENST00000438570.1_Intron	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	455					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						CCGCCAGAACGAATTCATGTA	0.567000													5	12					0	0	0.014758	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43769915	43769915	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:43769915C>T	ENST00000389420.3	-	35	5256	c.5257G>A	c.(5257-5259)Gaa>Aaa	p.E1753K		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1753	GON.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GTTAAATATTCCTTAGGGTTC	0.338000													5	6					0	0	0.014758	0	0
ATP13A4	84239	broad.mit.edu	37	3	193174929	193174929	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:193174929C>T	ENST00000342695.4	-	16	2097	c.1775G>A	c.(1774-1776)gGa>gAa	p.G592E	ATP13A4_ENST00000392443.3_Missense_Mutation_p.G573E	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	592					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GATTGCAATTCCTTCCACTGG	0.473000													28	63					0	0	0.019004	0	0
OR2D2	120776	broad.mit.edu	37	11	6913605	6913605	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:6913605G>A	ENST00000299459.2	-	1	225	c.127C>T	c.(127-129)Ctg>Ttg	p.L43L		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATTAGAAGCAGATTTCCAAGC	0.463000													6	3					0	0	0.001168	0	0
ANK3	288	broad.mit.edu	37	10	61831012	61831012	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:61831012C>T	ENST00000280772.1	-	37	9818	c.9627G>A	c.(9625-9627)gaG>gaA	p.E3209E	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3209	Poly-Glu.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCTGTTCCTCCTCCTCTGACT	0.468000													16	34					0	0	0.003163	0	0
CCDC27	148870	broad.mit.edu	37	1	3669103	3669103	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:3669103G>A	ENST00000294600.2	+	1	142	c.58G>A	c.(58-60)Gaa>Aaa	p.E20K		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	20										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		AGATCCACGGGAAAAGCCGGG	0.572000													21	24					0	0	0.018920	0	0
THAP4	51078	broad.mit.edu	37	2	242572592	242572592	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:242572592G>A	ENST00000407315.1	-	2	1411	c.980C>T	c.(979-981)tCc>tTc	p.S327F		NM_015963.5	NP_057047.4	Q8WY91	THAP4_HUMAN	THAP domain containing 4	327							DNA binding|metal ion binding			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	9		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		CTCGTTGATGGACATGGGGCT	0.642000													19	44					0	0	0.006122	0	0
FPR2	2358	broad.mit.edu	37	19	52272088	52272088	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:52272088C>T	ENST00000598776.1	+	2	949	c.177C>T	c.(175-177)gtC>gtT	p.V59V	FPR2_ENST00000340023.6_Silent_p.V59V|FPR2_ENST00000598953.1_Silent_p.V59V	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	59					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						CACGCACAGTCACCACCATCT	0.552000													34	64					0	0	0.019004	0	0
RNF217	154214	broad.mit.edu	37	6	125397990	125397990	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:125397990G>A	ENST00000521654.2	+	4	1469	c.1469G>A	c.(1468-1470)cGa>cAa	p.R490Q	RNF217_ENST00000275184.6_Missense_Mutation_p.R134Q|RNF217_ENST00000560949.1_Missense_Mutation_p.R255Q|RNF217_ENST00000368414.2_Missense_Mutation_p.R52Q|RNF217_ENST00000359704.2_Missense_Mutation_p.R198Q			Q8TC41	RN217_HUMAN	ring finger protein 217	198					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		AGATTAGTGCGAGGGTCAGTC	0.443000													5	11					0	0	0.001984	0	0
TRPM3	80036	broad.mit.edu	37	9	73151069	73151069	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:73151069C>T	ENST00000377110.2	-	25	5167	c.4924G>A	c.(4924-4926)Gag>Aag	p.E1642K	TRPM3_ENST00000360823.2_Missense_Mutation_p.E1504K|TRPM3_ENST00000396292.4_Missense_Mutation_p.E1514K|TRPM3_ENST00000423814.3_Missense_Mutation_p.E1669K|TRPM3_ENST00000377105.1_Missense_Mutation_p.E1501K|TRPM3_ENST00000396280.5_Missense_Mutation_p.E1491K|TRPM3_ENST00000377106.1_Missense_Mutation_p.E1514K|TRPM3_ENST00000408909.2_Missense_Mutation_p.E1501K|TRPM3_ENST00000377111.2_Intron|TRPM3_ENST00000357533.2_Missense_Mutation_p.E1646K|TRPM3_ENST00000396285.1_Missense_Mutation_p.E1501K|TRPM3_ENST00000358082.3_Missense_Mutation_p.E1504K	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	1667						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GCACTTGGCTCCTCTGCCGAG	0.537000													122	327					0	0	0.014410	0	0
KIF2B	84643	broad.mit.edu	37	17	51900694	51900694	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:51900694G>A	ENST00000268919.4	+	1	456	c.300G>A	c.(298-300)ctG>ctA	p.L100L		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	100					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CCTTGGCTCTGGCGCCCTCTT	0.592000													83	131					0	0	0.014410	0	0
ADCY10	55811	broad.mit.edu	37	1	167830287	167830287	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:167830287G>A	ENST00000367848.1	-	15	1852	c.1355C>T	c.(1354-1356)tCa>tTa	p.S452L	ADCY10_ENST00000367851.4_Missense_Mutation_p.S544L|ADCY10_ENST00000545172.1_Missense_Mutation_p.S391L			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	544					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						CTTATTCAATGAAATGGCAAT	0.333000													11	47					0	0	0.008291	0	0
HTR3E	285242	broad.mit.edu	37	3	183823660	183823660	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:183823660G>A	ENST00000415389.2	+	7	1294	c.828G>A	c.(826-828)ggG>ggA	p.G276G	HTR3E_ENST00000335304.2_Silent_p.G291G|HTR3E_ENST00000436361.2_Silent_p.G276G|HTR3E_ENST00000425359.2_Silent_p.G261G|HTR3E_ENST00000440596.2_Silent_p.G302G	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	276						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TGAAAAGTGGGAATCGTGTCC	0.552000													23	93					0	0	0.014323	0	0
DUSP12	11266	broad.mit.edu	37	1	161723034	161723034	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:161723034G>A	ENST00000367943.4	+	5	876	c.844G>A	c.(844-846)Gga>Aga	p.G282R	DUSP12_ENST00000484291.1_3'UTR	NM_007240.1	NP_009171.1	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	282					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|lung(1)	5	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			TGCTTTGTTGGGAGTGATGGA	0.353000													38	57					0	0	0.005524	0	0
TCP11	6954	broad.mit.edu	37	6	35088743	35088743	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:35088743C>T	ENST00000311875.5	-	6	1114	c.697G>A	c.(697-699)Gaa>Aaa	p.E233K	TCP11_ENST00000418521.2_Missense_Mutation_p.E157K|TCP11_ENST00000444780.2_Missense_Mutation_p.E228K|TCP11_ENST00000244645.3_Missense_Mutation_p.E158K|TCP11_ENST00000373979.2_Missense_Mutation_p.E158K|TCP11_ENST00000373974.4_Missense_Mutation_p.E187K|TCP11_ENST00000512012.1_Missense_Mutation_p.E220K|TCP11_ENST00000412155.2_Missense_Mutation_p.E182K			Q8WWU5	TCP11_HUMAN	t-complex 11, testis-specific	220					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						ATGGAATGTTCCTGCAGGTGG	0.478000													76	210					0	0	0.014410	0	0
TMOD2	29767	broad.mit.edu	37	15	52065922	52065922	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:52065922C>T	ENST00000249700.4	+	4	518	c.297C>T	c.(295-297)atC>atT	p.I99I	TMOD2_ENST00000539962.2_Silent_p.I55I|TMOD2_ENST00000435126.2_Silent_p.I99I	NM_001142885.1|NM_014548.3	NP_001136357.1|NP_055363.1	Q9NZR1	TMOD2_HUMAN	tropomodulin 2 (neuronal)	99					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16				all cancers(107;0.00435)		GAGTCTTTATCCCTAAAGAAA	0.418000													18	37					0	0	0.008871	0	0
GPR174	84636	broad.mit.edu	37	X	78426957	78426957	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:78426957C>T	ENST00000276077.1	+	1	489	c.453C>T	c.(451-453)ctC>ctT	p.L151L		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	151						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						CCTGTGTACTCTTTCCACTCC	0.483000										HNSCC(63;0.18)			13	4					0	0	0.016723	0	0
MMRN1	22915	broad.mit.edu	37	4	90830522	90830522	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:90830522G>A	ENST00000394980.1	+	3	1038	c.719G>A	c.(718-720)tGg>tAg	p.W240*	MMRN1_ENST00000508372.1_5'UTR|MMRN1_ENST00000264790.2_Nonsense_Mutation_p.W240*|MMRN1_ENST00000394981.1_Nonsense_Mutation_p.W206*			Q13201	MMRN1_HUMAN	multimerin 1	240	EMI.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CCTTGTGGCTGGACCGGTGGA	0.413000													2	1					0	0	0.004672	0	0
ACAN	176	broad.mit.edu	37	15	89384991	89384991	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:89384991G>A	ENST00000439576.2	+	5	1024	c.650G>A	c.(649-651)cGg>cAg	p.R217Q	ACAN_ENST00000561243.1_Missense_Mutation_p.R217Q|ACAN_ENST00000559004.1_Missense_Mutation_p.R217Q|ACAN_ENST00000558207.1_Missense_Mutation_p.R217Q|ACAN_ENST00000352105.7_Missense_Mutation_p.R217Q	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	217					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CACACTCCCCGGGAAGGCTGC	0.567000													23	68					0	0	0.004656	0	0
FCGBP	8857	broad.mit.edu	37	19	40408560	40408560	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:40408560G>A	ENST00000221347.6	-	8	4286	c.4279C>T	c.(4279-4281)Ccc>Tcc	p.P1427S		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1427	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGCAGGCAGGGAGAGTCGGGC	0.627000													17	37					0	0	0.004007	0	0
SEPT9	10801	broad.mit.edu	37	17	75471897	75471897	+	Silent	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:75471897T>G	ENST00000427180.1	+	1	573	c.297T>G	c.(295-297)cgT>cgG	p.R99R	SEPT9_ENST00000591088.1_Intron|SEPT9_ENST00000449803.2_Intron|SEPT9_ENST00000427177.1_Intron|SEPT9_ENST00000592420.1_Intron|SEPT9_ENST00000588690.1_Intron|SEPT9_ENST00000585930.1_Intron|SEPT9_ENST00000590294.1_Intron|SEPT9_ENST00000590917.1_Intron|SEPT9_ENST00000427674.2_Intron|SEPT9_ENST00000431235.2_Intron|SEPT9_ENST00000591198.1_Intron|SEPT9_ENST00000541152.2_Intron|SEPT9_ENST00000329047.8_Intron|SEPT9_ENST00000423034.2_Intron|SEPT9_ENST00000592481.1_Intron|SEPT9_ENST00000592951.1_Intron	NM_001113495.1	NP_001106967.1	Q9UHD8	SEPT9_HUMAN	septin 9	0					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			TCCCCTGCCGTGGCCTGGTCA	0.642000													59	53					0	0	0.014410	0	0
OBP2A	29991	broad.mit.edu	37	9	138439043	138439043	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:138439043C>T	ENST00000539850.1	+	3	252	c.226C>T	c.(226-228)Cag>Tag	p.Q76*	OBP2A_ENST00000342114.4_Missense_Mutation_p.P31L|OBP2A_ENST00000371776.1_Nonsense_Mutation_p.Q76*|OBP2A_ENST00000340780.3_Nonsense_Mutation_p.Q76*			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	76					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		TCGGTGCATCCAGAAGAAAAT	0.637000													13	57					0	0	0.020292	0	0
SLC9C1	285335	broad.mit.edu	37	3	111898498	111898498	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:111898498C>T	ENST00000305815.5	-	23	3051	c.2799G>A	c.(2797-2799)aaG>aaA	p.K933K	SLC9C1_ENST00000487372.1_Silent_p.K885K	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	933					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										AATCTTTCTCCTTTGACTCCA	0.348000													13	23					0	0	0.020292	0	0
AFTPH	54812	broad.mit.edu	37	2	64794825	64794825	+	Silent	SNP	A	A	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:64794825A>C	ENST00000422803.1	+	3	2379	c.2065A>C	c.(2065-2067)Aga>Cga	p.R689R	AFTPH_ENST00000487769.1_Intron|AFTPH_ENST00000238856.4_Silent_p.R689R|AFTPH_ENST00000409933.1_Silent_p.R689R|AFTPH_ENST00000238855.7_Silent_p.R689R|AFTPH_ENST00000409183.1_Silent_p.R320R			Q6ULP2	AFTIN_HUMAN	aftiphilin	689					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						AATAAAAACGAGAGAGGCCTT	0.368000													12	36					0	0	0.004007	0	0
NUTM1	256646	broad.mit.edu	37	15	34648236	34648236	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:34648236G>A	ENST00000537011.1	+	8	2409	c.2027G>A	c.(2026-2028)gGa>gAa	p.G676E	NUTM1_ENST00000333756.4_Missense_Mutation_p.G648E|NUTM1_ENST00000438749.3_Missense_Mutation_p.G666E					NUT midline carcinoma, family member 1																		CCTCTGCAAGGACAAGGGTTA	0.562000													16	46					0	0	0.004990	0	0
BTBD9	114781	broad.mit.edu	37	6	38142888	38142888	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:38142888G>A	ENST00000481247.1	-	11	1863	c.1712C>T	c.(1711-1713)tCg>tTg	p.S571L	BTBD9_ENST00000419706.2_Missense_Mutation_p.S541L|BTBD9_ENST00000403056.1_Missense_Mutation_p.S571L|BTBD9_ENST00000314100.6_Missense_Mutation_p.S503L|BTBD9_ENST00000408958.1_Missense_Mutation_p.S503L	NM_001099272.1|NM_052893.1	NP_001092742.1|NP_443125.1	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9	571					cell adhesion					breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	12						CCCTGTCCCCGATTCCTCACT	0.597000													20	85					0	0	0.010504	0	0
C1orf210	149466	broad.mit.edu	37	1	43748742	43748742	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:43748742G>A	ENST00000523677.1	-	3	289	c.56C>T	c.(55-57)gCt>gTt	p.A19V	C1orf210_ENST00000423420.1_Missense_Mutation_p.A19V	NM_001164829.1|NM_182517.2	NP_001158301.1|NP_872323.1	Q8IVY1	CA210_HUMAN	chromosome 1 open reading frame 210	19						integral to membrane				breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGGGGCCACAGCAGACGCTGT	0.637000													15	24					0	0	0.004007	0	0
TGM4	7047	broad.mit.edu	37	3	44945382	44945382	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:44945382C>T	ENST00000296125.4	+	9	1046	c.978C>T	c.(976-978)ttC>ttT	p.F326F		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	326					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity	p.F326L(1)		NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GCAGGAATTTCCATGTGTGGA	0.592000													39	111					0	0	0.010771	0	0
GEM	2669	broad.mit.edu	37	8	95264409	95264409	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:95264409C>T	ENST00000297596.2	-	4	715	c.451G>A	c.(451-453)Gac>Aac	p.D151N	GEM_ENST00000396194.2_Missense_Mutation_p.D151N	NM_005261.3	NP_005252.1	P55040	GEM_HUMAN	GTP binding protein overexpressed in skeletal muscle	151					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			AGGTATGCGTCCCCGACCTGC	0.522000													28	42					0	0	0.008361	0	0
PAK7	57144	broad.mit.edu	37	20	9546738	9546738	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:9546738G>A	ENST00000378429.3	-	6	1830	c.1284C>T	c.(1282-1284)tcC>tcT	p.S428S	PAK7_ENST00000378423.1_Silent_p.S428S|PAK7_ENST00000353224.5_Silent_p.S428S	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	428	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			ACTGTTCATGGGACACCCTGG	0.632000													23	46					0	0	0.016522	0	0
CD163L1	283316	broad.mit.edu	37	12	7585262	7585262	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:7585262G>A	ENST00000313599.3	-	4	573	c.516C>T	c.(514-516)ttC>ttT	p.F172F	CD163L1_ENST00000416109.2_Silent_p.F182F|CD163L1_ENST00000396630.1_Silent_p.F172F			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	172	SRCR 2.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						ACCTTTCTTGGAATTTCACCT	0.453000													17	32					0	0	0.007413	0	0
MKLN1	4289	broad.mit.edu	37	7	131060250	131060250	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:131060250C>G	ENST00000352689.6	+	2	206	c.166C>G	c.(166-168)Cag>Gag	p.Q56E	MKLN1_ENST00000421797.2_5'UTR|MKLN1_ENST00000429546.1_5'UTR	NM_013255.4	NP_037387.2	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing kelch motifs	56					signal transduction	cytoplasm	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	28	Melanoma(18;0.162)					CTATCCTCCCCAGGTAAGATT	0.323000													14	31					0	0	0.006122	0	0
TRPC5	7224	broad.mit.edu	37	X	111090650	111090650	+	Silent	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:111090650A>T	ENST00000262839.2	-	6	2310	c.1392T>A	c.(1390-1392)cgT>cgA	p.R464R		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	464					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CCTCCCTTGGACGAGAACCAT	0.428000													10	5					0	0	0.006214	0	0
FAM71B	153745	broad.mit.edu	37	5	156590543	156590543	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:156590543C>T	ENST00000302938.4	-	2	828	c.733G>A	c.(733-735)Gct>Act	p.A245T		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	245	Ala-rich.					nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCCGCACTAGCCGTTCCGTGG	0.587000													179	186					0	0	0.014410	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756493	94756493	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:94756493C>T	ENST00000554723.1	-	2	976	c.558G>A	c.(556-558)aaG>aaA	p.K186K	SERPINA10_ENST00000554173.1_Silent_p.K146K|SERPINA10_ENST00000261994.4_Silent_p.K146K|SERPINA10_ENST00000393096.1_Silent_p.K146K			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	146					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		CTCTGAGTCCCTTAAAGAGGG	0.572000													20	62					0	0	0.010504	0	0
KCNB2	9312	broad.mit.edu	37	8	73848248	73848248	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:73848248G>A	ENST00000523207.1	+	3	1246	c.658G>A	c.(658-660)Gaa>Aaa	p.E220K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	220					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GGAGCTGCAGGAAACGGACGA	0.473000													13	172					0	0	0.013537	0	0
OR2T6	254879	broad.mit.edu	37	1	248551338	248551338	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:248551338G>A	ENST00000355728.2	+	1	429	c.429G>A	c.(427-429)atG>atA	p.M143I		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCTGCTGGATGATCCTGGCCA	0.562000													8	52					0	0	0.006214	0	0
KLK11	11012	broad.mit.edu	37	19	51530734	51530734	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:51530734C>T	ENST00000594768.1	-	1	225	c.40G>A	c.(40-42)Ggc>Agc	p.G14S	KLK11_ENST00000391804.3_Intron|KLK11_ENST00000319720.7_Intron	NM_144947.1	NP_659196.1	Q9UBX7	KLK11_HUMAN	kallikrein-related peptidase 11	14					proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|GBM - Glioblastoma multiforme(134;0.00878)		AGACCTCTGCCCGATGACTTC	0.617000													45	122					0	0	0.014410	0	0
FAM47A	158724	broad.mit.edu	37	X	34148746	34148746	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:34148746A>G	ENST00000346193.3	-	1	1701	c.1650T>C	c.(1648-1650)agT>agC	p.S550S		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	550										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						ACACCCGACGACTCTTGGGAA	0.607000													20	19					0	0	0.010504	0	0
TTN	7273	broad.mit.edu	37	2	179604872	179604872	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:179604872G>A	ENST00000589042.1	-	48	13312	c.13088C>T	c.(13087-13089)cCc>cTc	p.P4363L	TTN_ENST00000591111.1_Missense_Mutation_p.P4046L|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P4125L|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Missense_Mutation_p.P4192L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P4000L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4046	Ig-like 23.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTGCCACGGGCTCTCTTTT	0.448000													5	17					0	0	0.014758	0	0
PIGL	9487	broad.mit.edu	37	17	16120544	16120544	+	Missense_Mutation	SNP	G	G	A	rs150000731		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:16120544G>A	ENST00000225609.5	+	1	21	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K	PIGL_ENST00000395844.3_Missense_Mutation_p.E2K|PIGL_ENST00000498772.2_Missense_Mutation_p.E2K|PIGL_ENST00000581006.1_Missense_Mutation_p.E2K	NM_004278.3	NP_004269.1	Q9Y2B2	PIGL_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class L	2					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminylphosphatidylinositol deacetylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	11				UCEC - Uterine corpus endometrioid carcinoma (92;0.0934)		ACCCATCATGGAAGCAATGTG	0.587000													17	25					0	0	0.004990	0	0
SIAH3	283514	broad.mit.edu	37	13	46357632	46357632	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:46357632C>T	ENST00000400405.2	-	2	802	c.696G>A	c.(694-696)ggG>ggA	p.G232G		NM_198849.2	NP_942146.2	Q8IW03	SIAH3_HUMAN	siah E3 ubiquitin protein ligase family member 3	232					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			large_intestine(3)|lung(7)|ovary(1)|skin(1)	12						CGAGGCAGTCCCCGTCCGTAA	0.612000													15	62					0	0	0.007413	0	0
ZNF821	55565	broad.mit.edu	37	16	71894513	71894513	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:71894513G>A	ENST00000425432.1	-	8	1026	c.647C>T	c.(646-648)tCc>tTc	p.S216F	ZNF821_ENST00000564134.1_3'UTR|RP11-498D10.4_ENST00000569119.1_Intron|ZNF821_ENST00000446827.2_Missense_Mutation_p.S174F|ZNF821_ENST00000565601.1_Missense_Mutation_p.S216F|RP11-498D10.4_ENST00000568581.1_Intron|ZNF821_ENST00000313565.6_Missense_Mutation_p.S174F	NM_001201552.1	NP_001188481.1	O75541	ZN821_HUMAN	zinc finger protein 821	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(2)	13						CTCAGCACTGGAGGGACCCTC	0.473000													30	57					0	0	0.009535	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21793478	21793478	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:21793478G>A	ENST00000206660.6	+	15	2303	c.2303G>A	c.(2302-2304)cGa>cAa	p.R768Q	RPGRIP1_ENST00000553500.1_3'UTR|RPGRIP1_ENST00000307974.4_Missense_Mutation_p.R127Q|RPGRIP1_ENST00000557771.1_Missense_Mutation_p.R730Q|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.R768Q|RPGRIP1_ENST00000556336.1_Intron|RPGRIP1_ENST00000382933.4_Intron			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	768					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TGCAATAAACGAAAGAAAGCC	0.542000													4	15					0	0	0.009096	0	0
KCNA6	3742	broad.mit.edu	37	12	4919931	4919931	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:4919931G>A	ENST00000433855.1	+	1	1590	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	KCNA6_ENST00000280684.3_Missense_Mutation_p.E242K	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	242						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						CACCCCTGGGGAAATGGGGAC	0.557000										HNSCC(72;0.22)			33	94					0	0	0.017118	0	0
ZNF536	9745	broad.mit.edu	37	19	31040064	31040064	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:31040064G>A	ENST00000355537.3	+	4	3685	c.3538G>A	c.(3538-3540)Gaa>Aaa	p.E1180K		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GAACAACGATGAAGAGGATGT	0.552000													19	49					0	0	0.008871	0	0
CDH20	28316	broad.mit.edu	37	18	59221766	59221766	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:59221766T>A	ENST00000262717.4	+	12	2642	c.2244T>A	c.(2242-2244)taT>taA	p.Y748*	CDH20_ENST00000536675.2_Nonsense_Mutation_p.Y748*|CDH20_ENST00000538374.1_Nonsense_Mutation_p.Y748*			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	748					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				TCCAGACGTATATGTTCGAGG	0.647000													9	21					0	0	0.004482	0	0
MSR1	4481	broad.mit.edu	37	8	16032717	16032717	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:16032717G>A	ENST00000350896.3	-	3	393	c.196C>T	c.(196-198)Cct>Tct	p.P66S	MSR1_ENST00000355282.2_Missense_Mutation_p.P66S|MSR1_ENST00000262101.5_Missense_Mutation_p.P66S|MSR1_ENST00000445506.2_Missense_Mutation_p.P84S|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000381998.4_Missense_Mutation_p.P66S	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	66					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCAATGAGAGGGATGAGAACT	0.413000													18	22					0	0	0.010504	0	0
FAM20A	54757	broad.mit.edu	37	17	66538260	66538260	+	Silent	SNP	C	C	T	rs150508189	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:66538260C>T	ENST00000592554.1	-	7	1697	c.975G>A	c.(973-975)acG>acA	p.T325T	PRKAR1A_ENST00000588188.2_Intron|FAM20A_ENST00000226094.5_5'UTR	NM_001243746.1|NM_017565.3	NP_001230675.1|NP_060035.2	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	325						extracellular region				cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|stomach(1)	9	Breast(10;1.64e-13)					CAGCATACTCCGTCTTGCACA	0.607000													30	35					0	0	0.009535	0	0
CSMD3	114788	broad.mit.edu	37	8	113516054	113516054	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:113516054G>A	ENST00000297405.5	-	30	5292	c.5048C>T	c.(5047-5049)tCt>tTt	p.S1683F	CSMD3_ENST00000343508.3_Missense_Mutation_p.S1643F|CSMD3_ENST00000352409.3_Missense_Mutation_p.S1683F|CSMD3_ENST00000455883.2_Missense_Mutation_p.S1579F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1683	CUB 9.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTAACTAACAGATCCATCACT	0.328000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	31					0	0	0.010504	0	0
ANKRD35	148741	broad.mit.edu	37	1	145561656	145561656	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:145561656G>A	ENST00000355594.4	+	10	1431	c.1344G>A	c.(1342-1344)ggG>ggA	p.G448G		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	448										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTACCAATGGGGCACAGACCT	0.572000													55	62					0	0	0.014410	0	0
TTN	7273	broad.mit.edu	37	2	179586805	179586805	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:179586805C>T	ENST00000589042.1	-	78	22809	c.22585G>A	c.(22585-22587)Gga>Aga	p.G7529R	TTN_ENST00000591111.1_Missense_Mutation_p.G7212R|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.G6285R|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7212	Ig-like 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACTTTCTCCAGCAATAACA	0.403000													13	43					0	0	0.003163	0	0
SLC17A8	246213	broad.mit.edu	37	12	100813746	100813746	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:100813746G>A	ENST00000323346.5	+	12	1892	c.1579G>A	c.(1579-1581)Gaa>Aaa	p.E527K	SLC17A8_ENST00000552697.1_3'UTR|SLC17A8_ENST00000392989.3_Missense_Mutation_p.E477K	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	527					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						TGACCAGGACGAATTAGCTGA	0.468000													12	30					0	0	0.010729	0	0
DNAH7	56171	broad.mit.edu	37	2	196681594	196681594	+	Silent	SNP	A	A	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:196681594A>C	ENST00000312428.6	-	51	9619	c.9519T>G	c.(9517-9519)tcT>tcG	p.S3173S		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3173	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CCTTGGAGGAAGATAATATCT	0.393000													21	45					0	0	0.016522	0	0
OTOF	9381	broad.mit.edu	37	2	26725235	26725235	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:26725235C>T	ENST00000272371.2	-	7	769	c.643G>A	c.(643-645)Gga>Aga	p.G215R	OTOF_ENST00000403946.3_Missense_Mutation_p.G215R	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	215					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGATCCAGTCCATCTCCTAGC	0.577000													15	29					0	0	0.007413	0	0
NFKBID	84807	broad.mit.edu	37	19	36381329	36381329	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:36381329G>A	ENST00000396901.1	-	10	1243	c.670C>T	c.(670-672)Cag>Tag	p.Q224*	NFKBID_ENST00000340950.2_Nonsense_Mutation_p.Q61*|NFKBID_ENST00000352614.2_Nonsense_Mutation_p.Q376*|NFKBID_ENST00000606253.1_Nonsense_Mutation_p.Q224*	NM_139239.1	NP_640332.1	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta	224					inflammatory response	nucleus		p.Q224*(1)		breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	14						AGCAGCAGCTGAACCAGAGTG	0.612000													30	62					0	0	0.015359	0	0
TTN	7273	broad.mit.edu	37	2	179612692	179612692	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:179612692T>C	ENST00000360870.5	-	46	14657	c.14435A>G	c.(14434-14436)cAc>cGc	p.H4812R	TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000578746.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	922	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCACCTCTGTGGTCTTCCAA	0.478000													4	14					0	0	0.009096	0	0
FASN	2194	broad.mit.edu	37	17	80042511	80042511	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:80042511G>A	ENST00000306749.2	-	27	4864	c.4646C>T	c.(4645-4647)tCc>tTc	p.S1549F		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1549					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GCGCAGCGAGGAGCAGACCCA	0.657000													5	13					0	0	0.014758	0	0
SCAND3	114821	broad.mit.edu	37	6	28541180	28541180	+	Missense_Mutation	SNP	G	G	A	rs142639079		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:28541180G>A	ENST00000452236.2	-	4	3103	c.2486C>T	c.(2485-2487)cCg>cTg	p.P829L		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	829					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity	p.P829L(1)		NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						cttggcaaccggaagtgctac	0.403000													15	65					0	0	0.020292	0	0
SDHC	6391	broad.mit.edu	37	1	161310395	161310395	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:161310395C>T	ENST00000367975.2	+	4	340	c.191C>T	c.(190-192)cCc>cTc	p.P64L	SDHC_ENST00000513009.1_Missense_Mutation_p.P30L|SDHC_ENST00000392169.2_Missense_Mutation_p.P11L|SDHC_ENST00000432287.2_Missense_Mutation_p.P30L|SDHC_ENST00000342751.4_Missense_Mutation_p.P64L|SDHC_ENST00000470743.2_3'UTR	NM_003001.3	NP_002992.1	Q99643	C560_HUMAN	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	64					respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II|plasma membrane succinate dehydrogenase complex	electron carrier activity|heme binding|succinate dehydrogenase activity			urinary_tract(1)	1	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Succinic acid(DB00139)	TGGTCTCTTCCCATGGCGATG	0.373000			"""Mis, N, F"""			"""paraganglioma, pheochromocytoma"""			Familial Paragangliomas;Carney-Stratakis syndrome				8	232					0	0	0.006214	0	0
TMEM119	338773	broad.mit.edu	37	12	108986010	108986010	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:108986010G>A	ENST00000392806.3	-	2	318	c.150C>T	c.(148-150)tcC>tcT	p.S50S		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	50						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						GGCTCGGGGAGGAGGCCGACG	0.716000													7	17					0	0	0.003080	0	0
PTPN14	5784	broad.mit.edu	37	1	214556657	214556657	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:214556657G>A	ENST00000366956.5	-	13	2735	c.2541C>T	c.(2539-2541)atC>atT	p.I847I	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	847					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CACTCACCCTGATCATCATCT	0.507000													29	46					0	0	0.008361	0	0
MYO1D	4642	broad.mit.edu	37	17	31098192	31098192	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:31098192T>G	ENST00000318217.5	-	6	969	c.665A>C	c.(664-666)cAg>cCg	p.Q222P	MYO1D_ENST00000394649.4_Missense_Mutation_p.Q134P|MYO1D_ENST00000583621.1_Missense_Mutation_p.Q222P|MYO1D_ENST00000579584.1_Missense_Mutation_p.Q222P	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	222	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			AAGGGATTTCTGGAGATGTAG	0.358000													17	73					0	0	0.014323	0	0
ADAM20	8748	broad.mit.edu	37	14	70991342	70991342	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:70991342G>A	ENST00000256389.3	-	2	527	c.283C>T	c.(283-285)Cct>Tct	p.P95S	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	45					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		ACCTTCAAAGGGATCACCACT	0.532000													7	10					0	0	0.004482	0	0
ITGA8	8516	broad.mit.edu	37	10	15697376	15697376	+	Silent	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:15697376G>T	ENST00000378076.3	-	11	1331	c.978C>A	c.(976-978)gtC>gtA	p.V326V		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	326					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CATCTGATACGACAACGGTAT	0.318000													4	47					0.00024832	0.000256452	0.009096	1	0
HSPG2	3339	broad.mit.edu	37	1	22203098	22203098	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:22203098G>A	ENST00000374695.3	-	22	2812	c.2733C>T	c.(2731-2733)ttC>ttT	p.F911F		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	911	Laminin EGF-like 4; truncated.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TACTCAGGTGGAAAGAGCCGT	0.592000													11	25					0	0	0.008291	0	0
COQ6	51004	broad.mit.edu	37	14	74428024	74428024	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:74428024C>T	ENST00000334571.2	+	9	1080	c.1040C>T	c.(1039-1041)cCt>cTt	p.P347L	COQ6_ENST00000554920.1_Intron|COQ6_ENST00000557780.1_3'UTR|COQ6_ENST00000394026.4_Missense_Mutation_p.P322L|ENTPD5_ENST00000557325.1_Intron|COQ6_ENST00000238709.4_Missense_Mutation_p.P272L	NM_182476.2	NP_872282.1	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 monooxygenase	347					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(234;0.00337)		GTTCTGTTTCCTCTTGGGTTG	0.587000													6	30					0	0	0.003080	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68165716	68165716	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:68165716G>T	ENST00000262215.3	-	18	3057	c.2668C>A	c.(2668-2670)Cta>Ata	p.L890I	ARFGEF1_ENST00000520381.1_Missense_Mutation_p.L344I	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	890					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GGGATTGTTAGTTCTTTTGTT	0.318000													14	46					2.31682e-05	2.39818e-05	0.003163	1	0
USP33	23032	broad.mit.edu	37	1	78177436	78177436	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:78177436A>T	ENST00000370793.1	-	22	2841	c.2495T>A	c.(2494-2496)aTt>aAt	p.I832N	USP33_ENST00000370794.3_Missense_Mutation_p.I801N|USP33_ENST00000370792.3_Missense_Mutation_p.I824N|USP33_ENST00000357428.1_Missense_Mutation_p.I832N	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	832	DUSP 2.				axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						TTTTACCCGAATAAAAATTTC	0.323000													12	46					0	0	0.016723	0	0
NRSN1	140767	broad.mit.edu	37	6	24146056	24146056	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:24146056G>A	ENST00000378491.4	+	4	771	c.470G>A	c.(469-471)cGa>cAa	p.R157Q		NM_080723.4	NP_542454.3	Q8IZ57	NRSN1_HUMAN	neurensin 1	157					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle				breast(1)|endometrium(2)|large_intestine(2)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	22						TTTAAAGAACGAATCGCAGAC	0.493000													9	53					0	0	0.004482	0	0
KLHL7	55975	broad.mit.edu	37	7	23183515	23183515	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:23183515C>T	ENST00000322231.7	+	7	1088	c.598C>T	c.(598-600)Cgc>Tgc	p.R200C	KLHL7_ENST00000542558.1_5'UTR|KLHL7_ENST00000539124.1_Missense_Mutation_p.R146C|KLHL7_ENST00000479288.1_3'UTR|KLHL7_ENST00000409689.1_Missense_Mutation_p.R174C|KLHL7_ENST00000545443.1_Missense_Mutation_p.R200C|KLHL7_ENST00000339077.4_Missense_Mutation_p.R222C			Q8IXQ5	KLHL7_HUMAN	kelch-like family member 7	222						Golgi apparatus|nucleolus|plasma membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TGAACCTAATCGCCAGCCATT	0.378000													42	102					0	0	0.013114	0	0
C9orf84	158401	broad.mit.edu	37	9	114518604	114518604	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:114518604C>T	ENST00000394779.3	-	4	798		c.e4+1		C9orf84_ENST00000374287.3_Splice_Site|C9orf84_ENST00000318737.4_Splice_Site|C9orf84_ENST00000374283.5_Splice_Site|C9orf84_ENST00000394777.4_Splice_Site	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84											breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TTAATTCTCACCTCTTTCAAA	0.294000													6	24					0	0	0.001168	0	0
FDPS	2224	broad.mit.edu	37	1	155279652	155279652	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:155279652G>C	ENST00000356657.6	+	2	234	c.72G>C	c.(70-72)gaG>gaC	p.E24D	FDPS_ENST00000447866.1_Intron|FDPS_ENST00000487002.1_3'UTR|FDPS_ENST00000368356.4_Missense_Mutation_p.E24D	NM_001135821.1	NP_001129293.1	P14324	FPPS_HUMAN	farnesyl diphosphate synthase	24					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	CACCCCGGGAGAGGTGGCTGG	0.682000													4	13					0	0	0.014758	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70667763	70667763	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:70667763G>A	ENST00000260126.3	-	4	1860	c.1154C>T	c.(1153-1155)tCt>tTt	p.S385F	SLCO5A1_ENST00000524945.1_Missense_Mutation_p.S385F|SLCO5A1_ENST00000530307.1_Missense_Mutation_p.S385F	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	385						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			AGCATCAACAGAAAATTTTTT	0.373000													19	37					0	0	0.007413	0	0
ACTB	60	broad.mit.edu	37	7	5567920	5567920	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:5567920G>C	ENST00000331789.5	-	4	985	c.794C>G	c.(793-795)tCc>tGc	p.S265C		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	265					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		ACCCAGGAAGGAAGGCTGGAA	0.607000													25	62					0	0	0.006320	0	0
SMPD3	55512	broad.mit.edu	37	16	68405628	68405628	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:68405628C>T	ENST00000219334.5	-	3	1060	c.457G>A	c.(457-459)Gag>Aag	p.E153K	SMPD3_ENST00000563226.1_Missense_Mutation_p.E153K|SMPD3_ENST00000568373.1_Missense_Mutation_p.E153K	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	153					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	TGCCCGATCTCCTTGGCCCGC	0.592000													8	31					0	0	0.006214	0	0
FBLN5	10516	broad.mit.edu	37	14	92336611	92336611	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:92336611G>A	ENST00000267620.10	-	12	1596	c.1427C>T	c.(1426-1428)tCc>tTc	p.S476F	FBLN5_ENST00000342058.4_Missense_Mutation_p.S435F|FBLN5_ENST00000556154.1_Missense_Mutation_p.S440F|FBLN5_ENST00000556961.1_5'UTR			Q9UBX5	FBLN5_HUMAN	fibulin 5	435					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	28		all_cancers(154;0.0722)				TCGGATCACGGAGCTGCCTCT	0.572000													28	87					0	0	0.007291	0	0
EGR2	1959	broad.mit.edu	37	10	64573153	64573153	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:64573153G>A	ENST00000242480.3	-	2	1570	c.1245C>T	c.(1243-1245)cgC>cgT	p.R415R	EGR2_ENST00000439032.1_Silent_p.R415R|EGR2_ENST00000411732.1_Silent_p.R365R	NM_000399.3|NM_001136177.1	NP_000390.2|NP_001129649.1	P11161	EGR2_HUMAN	early growth response 2	415					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	36	Prostate(12;0.0297)|all_hematologic(501;0.228)					TCTTGGTGTGGCGCTTCCTCT	0.617000													38	51					0	0	0.019004	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907865	12907865	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:12907865C>T	ENST00000317869.6	-	2	503	c.278G>A	c.(277-279)gGa>gAa	p.G93E		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						ACCTGCGTTTCCTCGGTTCAC	0.483000													13	97					0	0	0.003163	0	0
NLRP5	126206	broad.mit.edu	37	19	56539825	56539825	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:56539825G>A	ENST00000390649.3	+	7	2226	c.2226G>A	c.(2224-2226)ggG>ggA	p.G742G		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	742						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		ATGTCAAAGGGATCTTCCCAA	0.517000													68	164					0	0	0.014410	0	0
MUC16	94025	broad.mit.edu	37	19	8995652	8995652	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:8995652G>A	ENST00000397910.4	-	63	41539	c.41336C>T	c.(41335-41337)tCg>tTg	p.S13779L	MUC16_ENST00000380951.5_Missense_Mutation_p.S420L	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13781				Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCCAAATATCGAGGCTGGAGT	0.463000													11	25					0	0	0.016723	0	0
VRTN	55237	broad.mit.edu	37	14	74824603	74824603	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:74824603G>A	ENST00000256362.4	+	2	1358	c.1117G>A	c.(1117-1119)Gag>Aag	p.E373K		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	373					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						GGGCATGGAGGAGCTAGAGAA	0.647000													13	32					0	0	0.016723	0	0
NMBR	4829	broad.mit.edu	37	6	142399866	142399866	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:142399866G>A	ENST00000258042.1	-	2	737	c.597C>T	c.(595-597)atC>atT	p.I199I		NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	199					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		GAGGGTATGGGATACATGCTG	0.423000													11	22					0	0	0.013537	0	0
PAK7	57144	broad.mit.edu	37	20	9546835	9546835	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:9546835G>A	ENST00000378429.3	-	6	1733	c.1187C>T	c.(1186-1188)tCc>tTc	p.S396F	PAK7_ENST00000378423.1_Missense_Mutation_p.S396F|PAK7_ENST00000353224.5_Missense_Mutation_p.S396F	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	396	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			GGAAGCCGTGGAGATGTACTG	0.612000													15	53					0	0	0.003163	0	0
SLC33A1	9197	broad.mit.edu	37	3	155571302	155571302	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:155571302A>T	ENST00000392845.2	-	1	865	c.485T>A	c.(484-486)gTg>gAg	p.V162E	SLC33A1_ENST00000359479.3_Missense_Mutation_p.V162E	NM_004733.3	NP_004724.1	O00400	ACATN_HUMAN	solute carrier family 33 (acetyl-CoA transporter), member 1	162					cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	22			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CAAACGGTCCACCTGAGTGGA	0.473000													21	43					0	0	0.008871	0	0
OR4K14	122740	broad.mit.edu	37	14	20483185	20483185	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:20483185G>T	ENST00000305045.2	-	1	167	c.168C>A	c.(166-168)caC>caA	p.H56Q		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TAGGGGAGGAGTGCAGGCAGG	0.448000													7	29					5.4927e-09	5.747e-09	0.004482	1	0
PASD1	139135	broad.mit.edu	37	X	150844505	150844505	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:150844505G>A	ENST00000370357.4	+	16	2457	c.2212G>A	c.(2212-2214)Gat>Aat	p.D738N		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	738						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					GGGACCTCCTGATCCACAGGC	0.517000													55	43					0	0	0.014410	0	0
TRPM3	80036	broad.mit.edu	37	9	73240410	73240410	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:73240410C>T	ENST00000377105.1	-	13	1551	c.1197G>A	c.(1195-1197)tgG>tgA	p.W399*	TRPM3_ENST00000360823.2_Intron|TRPM3_ENST00000396292.4_Intron|TRPM3_ENST00000423814.3_Intron|TRPM3_ENST00000396280.5_Nonsense_Mutation_p.W399*|TRPM3_ENST00000377106.1_Intron|TRPM3_ENST00000408909.2_Nonsense_Mutation_p.W399*|TRPM3_ENST00000377110.2_Intron|TRPM3_ENST00000377111.2_Intron|TRPM3_ENST00000357533.2_Nonsense_Mutation_p.W554*|TRPM3_ENST00000396285.1_Intron|TRPM3_ENST00000358082.3_Intron	NM_024971.5|NM_206945.3	NP_079247.5|NP_996828.3	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	569						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TAAAATAGATCCAACCGAAAC	0.279000													12	54					0	0	0.004007	0	0
HEPHL1	341208	broad.mit.edu	37	11	93815599	93815599	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:93815599G>A	ENST00000315765.9	+	10	1740	c.1732G>A	c.(1732-1734)Gag>Aag	p.E578K		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	578	Plastocyanin-like 4.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AATAGACAAGGAGTTTTACCT	0.353000													9	12					0	0	0.008291	0	0
CCKAR	886	broad.mit.edu	37	4	26483489	26483489	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:26483489G>A	ENST00000295589.3	-	5	1252	c.1058C>T	c.(1057-1059)tCc>tTc	p.S353F		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	353					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	GAGGATGAAGGAAATGGGGGT	0.612000													26	63					0	0	0.005443	0	0
OR51E2	81285	broad.mit.edu	37	11	4703639	4703639	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:4703639G>A	ENST00000396950.3	-	2	542	c.303C>T	c.(301-303)ttC>ttT	p.F101F		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		CATGAATAAAGAACATCTGGG	0.522000													8	38					0	0	0.004482	0	0
KRT77	374454	broad.mit.edu	37	12	53096950	53096950	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:53096950C>T	ENST00000341809.3	-	1	297	c.269G>A	c.(268-270)gGa>gAa	p.G90E	KRT77_ENST00000537195.1_5'UTR	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	90	Head.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CCCTCCAAATCCCCCTACTCC	0.577000													4	12					0	0	0.014758	0	0
NLRP10	338322	broad.mit.edu	37	11	7981464	7981464	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:7981464G>A	ENST00000328600.2	-	2	1856	c.1695C>T	c.(1693-1695)ttC>ttT	p.F565F		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	565							ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CATACAGGGAGAATTCCAAAT	0.363000													17	39					0	0	0.007413	0	0
OIP5	11339	broad.mit.edu	37	15	41611941	41611941	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:41611941G>A	ENST00000220514.3	-	3	486	c.427C>T	c.(427-429)Ccc>Tcc	p.P143S		NM_007280.1	NP_009211.1	O43482	MS18B_HUMAN	Opa interacting protein 5	143					cell communication|cell division|CenH3-containing nucleosome assembly at centromere|mitosis	Cajal body|chromatin|chromosome, centromeric region	protein binding			endometrium(3)|lung(1)|urinary_tract(1)	5		all_cancers(109;4.16e-14)|all_epithelial(112;7.09e-12)|Lung NSC(122;1.14e-09)|all_lung(180;2.56e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)		OV - Ovarian serous cystadenocarcinoma(18;1.49e-16)|GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.163)		AAACCAACGGGAATCCCACAA	0.403000													9	22					0	0	0.004482	0	0
HEPACAM	220296	broad.mit.edu	37	11	124792320	124792320	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:124792320C>T	ENST00000298251.4	-	6	1317	c.912G>A	c.(910-912)cgG>cgA	p.R304R		NM_152722.4	NP_689935.2	Q14CZ8	HECAM_HUMAN	hepatic and glial cell adhesion molecule	304					cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TGGGGTTCTTCCGTTCCTGCT	0.602000													43	96					0	0	0.014410	0	0
ACTB	60	broad.mit.edu	37	7	5567919	5567919	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:5567919G>A	ENST00000331789.5	-	4	986	c.795C>T	c.(793-795)tcC>tcT	p.S265S		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	265					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		CACCCAGGAAGGAAGGCTGGA	0.612000													26	63					0	0	0.007291	0	0
EXTL3	2137	broad.mit.edu	37	8	28608236	28608236	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:28608236C>T	ENST00000220562.4	+	7	3515	c.2613C>T	c.(2611-2613)tcC>tcT	p.S871S	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Silent_p.S487S	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	871						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		ATGATGACTCCCACTTCCACG	0.567000													29	43					0	0	0.010818	0	0
CPA6	57094	broad.mit.edu	37	8	68334778	68334778	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:68334778C>T	ENST00000297770.4	-	11	1490	c.1275G>A	c.(1273-1275)gtG>gtA	p.V425V	CPA6_ENST00000297769.4_Silent_p.V181V	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6	425					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			TGATATTTTTCACAGCCAGCA	0.458000													42	120					0	0	0.013114	0	0
WTIP	126374	broad.mit.edu	37	19	34985514	34985514	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:34985514C>T	ENST00000590071.2	+	6	1392	c.1055C>T	c.(1054-1056)tCc>tTc	p.S352F	WTIP_ENST00000270288.6_Missense_Mutation_p.S576F	NM_001080436.1	NP_001073905.1			Wilms tumor 1 interacting protein											NS(1)|large_intestine(2)|lung(1)	4	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			AAATGCGCCTCCTGTGCCCGT	0.577000													6	23					0	0	0.003080	0	0
ANKEF1	63926	broad.mit.edu	37	20	10036266	10036266	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:10036266C>T	ENST00000378380.3	+	10	2618	c.2289C>T	c.(2287-2289)atC>atT	p.I763I	SNAP25-AS1_ENST00000603542.1_RNA|ANKEF1_ENST00000488991.1_3'UTR|ANKEF1_ENST00000378392.1_Silent_p.I763I|SNAP25-AS1_ENST00000421143.2_RNA	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		AGAAGAACATCACAGAGAAAG	0.478000													10	10					0	0	0.008291	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834496	101834496	+	Missense_Mutation	SNP	C	C	T	rs112814311		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:101834496C>T	ENST00000506729.1	-	1	224	c.53G>A	c.(52-54)gGa>gAa	p.G18E	SLCO6A1_ENST00000379807.3_Missense_Mutation_p.G18E|SLCO6A1_ENST00000379810.1_Missense_Mutation_p.G18E|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.G18E|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.G18E			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	18						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CGGCTCTACTCCCCTTGAGAC	0.672000													137	145					0	0	0.014410	0	0
IRS4	8471	broad.mit.edu	37	X	107976623	107976623	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:107976623A>G	ENST00000372129.2	-	1	3028	c.2952T>C	c.(2950-2952)cgT>cgC	p.R984R		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	984						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						AGGGGTTGGCACGTGGTATAG	0.478000													34	29					0	0	0.013726	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14851567	14851567	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:14851567G>A	ENST00000358984.4	+	36	3447	c.3267G>A	c.(3265-3267)aaG>aaA	p.K1089K		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1174										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TGTTGAAAAAGGAAATTGCCA	0.303000													3	16					0	0	0.009096	0	0
MET	4233	broad.mit.edu	37	7	116339180	116339180	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:116339180C>T	ENST00000397752.3	+	2	242	c.42C>T	c.(40-42)ctC>ctT	p.L14L	MET_ENST00000436117.2_Silent_p.L14L|MET_ENST00000318493.6_Silent_p.L14L	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	14					axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TCCTCGTGCTCCTGTTTACCT	0.493000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				4	19					0	0	0.014758	0	0
RTN1	6252	broad.mit.edu	37	14	60194302	60194302	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:60194302G>A	ENST00000267484.5	-	3	1435	c.1100C>T	c.(1099-1101)tCg>tTg	p.S367L		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	367					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GGTTTCATACGATAATCCCTT	0.622000													6	18					0	0	0.001984	0	0
LLGL2	3993	broad.mit.edu	37	17	73555366	73555366	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:73555366C>T	ENST00000392550.3	+	6	522	c.405C>T	c.(403-405)gtC>gtT	p.V135V	LLGL2_ENST00000375227.4_Silent_p.V135V|LLGL2_ENST00000578363.1_Silent_p.V135V|LLGL2_ENST00000167462.5_Silent_p.V135V|LLGL2_ENST00000577200.1_Silent_p.V135V	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	135					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			TCACCGTGGTCCTGCCACATT	0.642000													6	41					0	0	0.001984	0	0
SRD5A2	6716	broad.mit.edu	37	2	31754518	31754518	+	RNA	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:31754518A>G	ENST00000405650.1	-	0	722				AL133247.2_ENST00000435713.1_RNA			P31213	S5A2_HUMAN	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)						androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity					Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	AACATACGTAAACAAGCCACC	0.453000													6	13					0	0	0.001168	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186909142	186909142	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:186909142G>A	ENST00000367466.3	+	10	1101	c.949G>A	c.(949-951)Gaa>Aaa	p.E317K	PLA2G4A_ENST00000442353.2_Missense_Mutation_p.E257K	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	317	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	CAGTTTGAAGGAAAAAGTTAA	0.358000													9	7					0	0	0.008291	0	0
FZD8	8325	broad.mit.edu	37	10	35928513	35928513	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:35928513G>A	ENST00000374694.1	-	1	1849	c.1845C>T	c.(1843-1845)tcC>tcT	p.S615S		NM_031866.2	NP_114072.1	Q9H461	FZD8_HUMAN	frizzled family receptor 8	615					axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	11						GGGTGCACAGGGAGCGCCAGG	0.746000													4	11					0	0	0.009096	0	0
KCNC3	3748	broad.mit.edu	37	19	50823976	50823976	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:50823976G>A	ENST00000376959.2	-	3	2207	c.2044C>T	c.(2044-2046)Cag>Tag	p.Q682*	KCNC3_ENST00000477616.1_Nonsense_Mutation_p.Q682*|KCNC3_ENST00000474951.1_5'UTR|KCNC3_ENST00000391818.2_Silent_p.T18T			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	682					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		ATGGCAGGCTGGTCAATGGCT	0.647000													18	31					0	0	0.008871	0	0
FLNC	2318	broad.mit.edu	37	7	128481572	128481572	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:128481572C>T	ENST00000325888.8	+	13	2333	c.2072C>T	c.(2071-2073)aCc>aTc	p.T691I	FLNC_ENST00000346177.6_Missense_Mutation_p.T691I	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	691					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GCTGAGTTCACCATTGATGCT	0.607000													53	179					0	0	0.014410	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136302870	136302870	+	Splice_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:136302870G>A	ENST00000371929.3	+	13	1881	c.1435_splice	c.e13-1	p.G479_splice	ADAMTS13_ENST00000356589.2_Splice_Site_p.G448_splice|ADAMTS13_ENST00000536611.1_Splice_Site_p.G151_splice|ADAMTS13_ENST00000371916.1_3'UTR|ADAMTS13_ENST00000485925.1_Intron|ADAMTS13_ENST00000355699.2_Splice_Site_p.G479_splice	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	479					cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CCCTCCCAGGGGATGCTCTGT	0.607000													7	43					0	0	0.003080	0	0
ABHD12B	145447	broad.mit.edu	37	14	51352531	51352531	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:51352531G>A	ENST00000337334.2	+	7	595	c.580G>A	c.(580-582)Gat>Aat	p.D194N	ABHD12B_ENST00000353130.1_Missense_Mutation_p.D117N|PYGL_ENST00000532462.1_Intron|ABHD12B_ENST00000554241.1_3'UTR|ABHD12B_ENST00000395752.1_Missense_Mutation_p.D87N	NM_001206673.1	NP_001193602.1	Q7Z5M8	AB12B_HUMAN	abhydrolase domain containing 12B	194							hydrolase activity			breast(2)|endometrium(1)|large_intestine(2)|lung(5)	10	all_epithelial(31;0.00481)|Breast(41;0.148)					ACTGACTACGGATGCCATTTG	0.517000													34	96					0	0	0.010818	0	0
NARG2	79664	broad.mit.edu	37	15	60715915	60715915	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:60715915G>A	ENST00000261520.4	-	16	3101	c.2867C>T	c.(2866-2868)tCc>tTc	p.S956F	NARG2_ENST00000439632.1_Missense_Mutation_p.S819F	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	956						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						GGTTTCCATGGAAACTGGATT	0.418000													8	14					0	0	0.003080	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555154	44555154	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:44555154C>T	ENST00000330682.2	-	1	1295	c.1060G>A	c.(1060-1062)Gac>Aac	p.D354N	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	354	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						CCTTCCACGTCGCCGAGGGCG	0.662000													20	602					0	0	0.005443	0	0
OXTR	5021	broad.mit.edu	37	3	8794707	8794707	+	Missense_Mutation	SNP	G	G	A	rs35062132	by1000genomes	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:8794707G>A	ENST00000316793.3	-	4	1750	c.1126C>T	c.(1126-1128)Cgc>Tgc	p.R376C	CAV3_ENST00000472766.1_Intron	NM_000916.3	NP_000907.2	P30559	OXYR_HUMAN	oxytocin receptor	376					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	CTGGAGCTGCGATGGCTCAGG	0.642000													11	27					0	0	0.008291	0	0
SCN3A	6328	broad.mit.edu	37	2	165984368	165984368	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:165984368C>T	ENST00000360093.3	-	18	3657	c.3166G>A	c.(3166-3168)Gaa>Aaa	p.E1056K	SCN3A_ENST00000283254.7_Missense_Mutation_p.E1056K|SCN3A_ENST00000409101.3_Missense_Mutation_p.E1007K	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1056						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TTGCTTATTTCAATTCCAGTA	0.373000													13	31					0	0	0.020292	0	0
SCN11A	11280	broad.mit.edu	37	3	38991652	38991652	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:38991652C>T	ENST00000302328.3	-	1	400	c.202G>A	c.(202-204)Gac>Aac	p.D68N	SCN11A_ENST00000456224.3_Missense_Mutation_p.D68N|SCN11A_ENST00000444237.2_Missense_Mutation_p.D68N|SCN11A_ENST00000450244.1_Missense_Mutation_p.D68N	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	68					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CGAGGAATGTCGCCATAGAGC	0.542000													34	136					0	0	0.005524	0	0
UBR1	197131	broad.mit.edu	37	15	43314912	43314912	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:43314912G>A	ENST00000290650.4	-	26	2905	c.2827C>T	c.(2827-2829)Cat>Tat	p.H943Y	UBR1_ENST00000382177.2_3'UTR	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	943					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GAAGCCTTATGATAAAAGTCA	0.338000													16	50					0	0	0.004990	0	0
NLRP1	22861	broad.mit.edu	37	17	5462774	5462774	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:5462774C>T	ENST00000345221.3	-	4	1796	c.1242G>A	c.(1240-1242)gaG>gaA	p.E414E	NLRP1_ENST00000577119.1_Silent_p.E414E|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000269280.4_Silent_p.E414E|NLRP1_ENST00000572272.1_Silent_p.E414E|NLRP1_ENST00000354411.3_Silent_p.E414E|NLRP1_ENST00000262467.5_Silent_p.E414E	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	414	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				CCCATCCTGGCTCATCTACAC	0.582000													17	23					0	0	0.004990	0	0
PPRC1	23082	broad.mit.edu	37	10	103898705	103898705	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:103898705G>T	ENST00000278070.2	+	4	598	c.559G>T	c.(559-561)Ggg>Tgg	p.G187W	PPRC1_ENST00000413464.2_Missense_Mutation_p.G187W	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding	p.G187R(1)		central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TGACCCACTGGGGCCCAGTAC	0.572000													17	46					2.35188e-11	2.47221e-11	0.006122	1	0
CREB3L2	64764	broad.mit.edu	37	7	137593038	137593038	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:137593038G>A	ENST00000330387.6	-	5	1079	c.728C>T	c.(727-729)cCc>cTc	p.P243L	CREB3L2_ENST00000456390.1_Missense_Mutation_p.P243L	NM_194071.3	NP_919047.2	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2	243					chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						GAGGGCGGAGGGGGCCCGGGG	0.657000			T	FUS	fibromyxoid sarcoma								3	3					0	0	0.009096	0	0
GLRA3	8001	broad.mit.edu	37	4	175565126	175565126	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:175565126G>A	ENST00000274093.3	-	10	1708	c.1206C>T	c.(1204-1206)ggC>ggT	p.G402G	GLRA3_ENST00000340217.5_Silent_p.G387G	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	402					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GGTGGTTGGGGCCCTTTGGAG	0.498000													22	57					0	0	0.004656	0	0
COL11A1	1301	broad.mit.edu	37	1	103343594	103343594	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:103343594G>A	ENST00000358392.2	-	67	5755	c.5438C>T	c.(5437-5439)cCt>cTt	p.P1813L	COL11A1_ENST00000370096.3_Missense_Mutation_p.P1801L|COL11A1_ENST00000512756.1_Missense_Mutation_p.P1685L|COL11A1_ENST00000353414.4_Missense_Mutation_p.P1762L	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1801					collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AAAACAAACAGGACCAACTTC	0.353000													13	24					0	0	0.003163	0	0
APOB	338	broad.mit.edu	37	2	21228841	21228841	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:21228841C>T	ENST00000233242.1	-	26	11026	c.10899G>A	c.(10897-10899)tgG>tgA	p.W3633*		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3633					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTTCATTTTTCCATCTGATCT	0.483000													74	164					0	0	0.014410	0	0
VRTN	55237	broad.mit.edu	37	14	74825172	74825172	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:74825172C>T	ENST00000256362.4	+	2	1927	c.1686C>T	c.(1684-1686)gtC>gtT	p.V562V		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	562					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						AGGTGCCGGTCCCCACCTTGG	0.632000													24	58					0	0	0.018920	0	0
DBH	1621	broad.mit.edu	37	9	136501608	136501608	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:136501608G>A	ENST00000393056.2	+	1	127	c.115G>A	c.(115-117)Ggc>Agc	p.G39S		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	39					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CGCACTGCAGGGCTCGGCTCC	0.667000													12	55					0	0	0.010729	0	0
KLRG2	346689	broad.mit.edu	37	7	139164442	139164442	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:139164442C>T	ENST00000340940.4	-	3	1005	c.936G>A	c.(934-936)caG>caA	p.Q312Q	KLRG2_ENST00000393039.2_Intron	NM_198508.2	NP_940910.1	A4D1S0	KLRG2_HUMAN	killer cell lectin-like receptor subfamily G, member 2	312	C-type lectin.					integral to membrane	sugar binding			central_nervous_system(1)|large_intestine(2)|lung(3)	6	Melanoma(164;0.233)					CTTCCCAGGCCTGCGCTTCTG	0.612000													18	77					0	0	0.007413	0	0
CFHR5	81494	broad.mit.edu	37	1	196953100	196953100	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:196953100C>T	ENST00000367414.5	+	3	391	c.335C>T	c.(334-336)tCc>tTc	p.S112F	CFHR5_ENST00000256785.4_Missense_Mutation_p.S88F	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	88	Sushi 2.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						GGAATGTGTTCCTTTCCTTTT	0.308000													7	22					0	0	0.001984	0	0
SCFD2	152579	broad.mit.edu	37	4	54140030	54140030	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:54140030C>T	ENST00000401642.3	-	4	1407	c.1274G>A	c.(1273-1275)tGg>tAg	p.W425*	SCFD2_ENST00000388940.4_Nonsense_Mutation_p.W425*	NM_152540.3	NP_689753.2	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	425					protein transport|vesicle docking involved in exocytosis					breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	30			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			AAAGTTGTCCCACTTGGCAGT	0.448000													23	41					0	0	0.016522	0	0
TMIGD1	388364	broad.mit.edu	37	17	28652031	28652031	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:28652031T>C	ENST00000328886.4	-	4	515	c.443A>G	c.(442-444)aAc>aGc	p.N148S	TMIGD1_ENST00000538566.2_Missense_Mutation_p.N148S	NM_206832.1	NP_996663.1	Q6UXZ0	TMIG1_HUMAN	transmembrane and immunoglobulin domain containing 1	148	Ig-like C2-type 2.					integral to membrane				breast(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	12						AGCCTGGGGGTTGGCTTTCAC	0.443000													66	89					0	0	0.014410	0	0
MUC16	94025	broad.mit.edu	37	19	9088081	9088081	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:9088081G>A	ENST00000397910.4	-	1	3937	c.3734C>T	c.(3733-3735)tCa>tTa	p.S1245L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1245	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.S1245*(2)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGTTTGTTGATTCAGGGTA	0.507000													187	183					0	0	0.014410	0	0
CFHR4	10877	broad.mit.edu	37	1	196876120	196876120	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:196876120C>T	ENST00000367416.2	+	4	703	c.566C>T	c.(565-567)tCc>tTc	p.S189F	CFHR4_ENST00000367418.1_Intron|CFHR4_ENST00000251424.4_Intron|CFHR2_ENST00000367421.3_Intron	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						ACCACAGATTCCATAGTGTGT	0.368000													3	11					0	0	0.004672	0	0
CACNA1F	778	broad.mit.edu	37	X	49063311	49063311	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:49063311G>A	ENST00000376265.2	-	45	5331	c.5270C>T	c.(5269-5271)tCc>tTc	p.S1757F	CACNA1F_ENST00000376251.1_Missense_Mutation_p.S1692F|CACNA1F_ENST00000323022.5_Missense_Mutation_p.S1746F	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1757					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	ATCTAGGTAGGAAAGCCTGTG	0.632000													17	7					0	0	0.008871	0	0
ABCB1	5243	broad.mit.edu	37	7	87173569	87173569	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:87173569G>A	ENST00000265724.3	-	18	2504	c.2087C>T	c.(2086-2088)tCc>tTc	p.S696F	ABCB1_ENST00000543898.1_Missense_Mutation_p.S632F	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	696					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CCTCCAAAAGGAAACTGGAGG	0.328000													25	49					0	0	0.009535	0	0
CACNA1B	774	broad.mit.edu	37	9	140991040	140991040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:140991040G>A	ENST00000277549.5	+	37	5350	c.2781G>A	c.(2779-2781)tgG>tgA	p.W927*	CACNA1B_ENST00000371355.4_Nonsense_Mutation_p.W1734*|CACNA1B_ENST00000371363.1_Nonsense_Mutation_p.W1731*|CACNA1B_ENST00000277551.2_Nonsense_Mutation_p.W1733*|CACNA1B_ENST00000371372.1_Nonsense_Mutation_p.W1733*|CACNA1B_ENST00000371357.1_Nonsense_Mutation_p.W1732*|CACNA1B_ENST00000371365.2_Nonsense_Mutation_p.W97*			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1733					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCCGGGTCTGGGCTGAATACG	0.562000													11	49					0	0	0.008291	0	0
TAF1	6872	broad.mit.edu	37	X	70679093	70679093	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:70679093C>T	ENST00000449580.1	+	36	5206	c.5155C>T	c.(5155-5157)Cca>Tca	p.P1719S	TAF1_ENST00000423759.1_Intron|TAF1_ENST00000276072.3_Intron|TAF1_ENST00000373790.4_Intron|TAF1_ENST00000461764.1_3'UTR			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	1687	Asp/Glu-rich (acidic tail).|Protein kinase 2.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				ACCTAAGACTCCAGCCCCAGT	0.488000													20	15					0	0	0.012319	0	0
MYO5C	55930	broad.mit.edu	37	15	52571166	52571166	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:52571166C>T	ENST00000261839.7	-	4	514	c.353G>A	c.(352-354)gGa>gAa	p.G118E	MYO5C_ENST00000443683.2_5'UTR|MYO5C_ENST00000541028.1_5'UTR	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	118	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		GATGGCATCTCCGTATATTGG	0.488000													30	55					0	0	0.010818	0	0
HS3ST1	9957	broad.mit.edu	37	4	11400857	11400857	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:11400857C>T	ENST00000002596.5	-	2	1947	c.773G>A	c.(772-774)cGg>cAg	p.R258Q		NM_005114.2	NP_005105.1	O14792	HS3S1_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	258						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(3)	15						GCCGCTGTCCCGCAGGCAGTA	0.512000													18	49					0	0	0.004990	0	0
THEM5	284486	broad.mit.edu	37	1	151825969	151825969	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:151825969G>A	ENST00000368817.5	-	1	204	c.73C>T	c.(73-75)Ctg>Ttg	p.L25L		NM_182578.3	NP_872384.1	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	25							hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGTCTGGGCAGGATACGGGGG	0.582000													32	142					0	0	0.021022	0	0
SPG7	6687	broad.mit.edu	37	16	89603237	89603237	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:89603237C>T	ENST00000341316.2	+	10	1396	c.1389C>T	c.(1387-1389)gcC>gcT	p.A463A	SPG7_ENST00000268704.2_Intron	NM_199367.1	NP_955399.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	343					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		AGACCCCCGCCTGCTCCTGTC	0.587000													49	136					0	0	0.014410	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18793380	18793380	+	Silent	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:18793380T>G	ENST00000433979.1	+	31	4193	c.4077T>G	c.(4075-4077)tcT>tcG	p.S1359S	PIK3C2G_ENST00000266497.5_Silent_p.S1359S|PIK3C2G_ENST00000538779.1_Silent_p.S1400S	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1359	C2.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				CAGATGGCTCTGCGCCCAGTG	0.383000													4	8					0	0	0.001168	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537394	5537394	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:5537394C>A	ENST00000380184.1	-	1	541	c.278G>T	c.(277-279)gGc>gTc	p.G93V	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	93	Ubiquitin-like.									endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GATGGTGTGGCCATCCATGAT	0.547000													9	41					5.50884e-06	5.71537e-06	0.013537	1	0
RSPH9	221421	broad.mit.edu	37	6	43638552	43638552	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:43638552G>C	ENST00000372165.4	+	6	802	c.749G>C	c.(748-750)gGg>gCg	p.G250A	RSPH9_ENST00000372163.4_Missense_Mutation_p.G233R	NM_001193341.1	NP_001180270.1	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog (Chlamydomonas)	0					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						GATGGAGAGGGGCAATGCCCT	0.632000									Kartagener syndrome				26	45					0	0	0.009535	0	0
OR9K2	441639	broad.mit.edu	37	12	55523577	55523577	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:55523577C>T	ENST00000305377.5	+	1	113	c.25C>T	c.(25-27)Cat>Tat	p.H9Y		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						ACCAAGAGTTCATTTGTATAT	0.348000													7	16					0	0	0.003080	0	0
DHX9	1660	broad.mit.edu	37	1	182847207	182847207	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:182847207C>T	ENST00000367549.3	+	20	2360	c.2250C>T	c.(2248-2250)acC>acT	p.T750T	DHX9_ENST00000485081.1_3'UTR	NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	750	Helicase C-terminal.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						ACTATGCTACCGTATGGGCAT	0.448000													14	16					0	0	0.004990	0	0
WBSCR17	64409	broad.mit.edu	37	7	71036340	71036340	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:71036340C>T	ENST00000333538.5	+	6	1667	c.1033C>T	c.(1033-1035)Cct>Tct	p.P345S	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	345	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TCTTCTGGATCCTGGCATGGA	0.502000													35	95					0	0	0.019004	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21051369	21051369	+	Splice_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:21051369G>A	ENST00000381545.3	+	14	1901		c.e14-1		SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000553473.1_Splice_Site|SLCO1B3_ENST00000261196.2_Splice_Site|LST3_ENST00000540229.1_Splice_Site|LST3_ENST00000381541.3_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3						bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TCATATTTCAGGATTGTTCAA	0.299000													6	26					0	0	0.001168	0	0
SLC15A3	51296	broad.mit.edu	37	11	60711223	60711223	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:60711223C>A	ENST00000227880.3	-	3	1167	c.934G>T	c.(934-936)Gtg>Ttg	p.V312L		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	312					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						TTCACCAGCACCTGGAAGTTG	0.617000													6	45					0.00116845	0.00120579	0.001168	1	0
C7orf63	79846	broad.mit.edu	37	7	89897659	89897659	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:89897659G>T	ENST00000389297.4	+	6	744	c.493G>T	c.(493-495)Gat>Tat	p.D165Y	AC002064.4_ENST00000420245.1_RNA|C7orf63_ENST00000497910.1_Intron|C7orf63_ENST00000463311.1_3'UTR|C7orf63_ENST00000316089.8_Missense_Mutation_p.D165Y	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	165							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						GTGTATTGTTGATTTTTATCA	0.338000													8	12					5.4927e-09	5.747e-09	0.004482	1	0
SLC28A1	9154	broad.mit.edu	37	15	85478734	85478734	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:85478734G>A	ENST00000394573.1	+	15	1768	c.1566G>A	c.(1564-1566)agG>agA	p.R522R	SLC28A1_ENST00000537216.1_Silent_p.R522R|SLC28A1_ENST00000537624.1_Silent_p.R522R|SLC28A1_ENST00000286749.3_Silent_p.R522R|SLC28A1_ENST00000538177.1_Intron	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	522					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCGGCGACAGGAAGCAGTGGA	0.627000													41	87					0	0	0.008740	0	0
SEMG2	6407	broad.mit.edu	37	20	43851307	43851307	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:43851307A>C	ENST00000372769.3	+	2	1124	c.1034A>C	c.(1033-1035)aAa>aCa	p.K345T		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	345	4 X 60 AA tandem repeats, type I.|Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				AAGGAAAATAAAATATCATAC	0.383000													9	28					0	0	0.004482	0	0
CCDC149	91050	broad.mit.edu	37	4	24838983	24838983	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:24838983C>G	ENST00000504487.1	-	6	535	c.529G>C	c.(529-531)Gag>Cag	p.E177Q	CCDC149_ENST00000428116.2_Intron|CCDC149_ENST00000389609.4_Missense_Mutation_p.E177Q|CCDC149_ENST00000502801.1_Intron	NM_001130726.2	NP_001124198.1	B4DZG3	B4DZG3_HUMAN	coiled-coil domain containing 149	177										cervix(1)|endometrium(1)|large_intestine(2)|lung(3)	7		Breast(46;0.173)				TCCTGAAGCTCGTCCACAGAA	0.522000													18	48					0	0	0.008871	0	0
UGT3A2	167127	broad.mit.edu	37	5	36039718	36039718	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:36039718G>A	ENST00000282507.3	-	5	1037	c.936C>T	c.(934-936)atC>atT	p.I312I	UGT3A2_ENST00000545528.1_Silent_p.I10I|UGT3A2_ENST00000513300.1_Silent_p.I278I	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	312						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCTCCTTGAAGATTTCCGGAT	0.493000													38	55					0	0	0.005524	0	0
LRP1B	53353	broad.mit.edu	37	2	141245207	141245207	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:141245207A>T	ENST00000389484.3	-	58	10193	c.9222T>A	c.(9220-9222)tgT>tgA	p.C3074*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3074					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCCATTTAAACACATTCTAT	0.299000										TSP Lung(27;0.18)			8	28					0	0	0.004482	0	0
COL16A1	1307	broad.mit.edu	37	1	32126196	32126196	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:32126196G>A	ENST00000373672.3	-	62	4385	c.3869C>T	c.(3868-3870)cCg>cTg	p.P1290L	COL16A1_ENST00000271069.6_Missense_Mutation_p.P1290L	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1290	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		AACGTGTCCCGGGGGACCGGG	0.527000													35	74					0	0	0.014410	0	0
A2ML1	144568	broad.mit.edu	37	12	8995919	8995919	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:8995919G>A	ENST00000299698.7	+	12	1618	c.1438G>A	c.(1438-1440)Gat>Aat	p.D480N		NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	324						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						CGACCCGGCCGATGCAAGCCC	0.562000													21	33					0	0	0.016522	0	0
ZNF556	80032	broad.mit.edu	37	19	2877344	2877344	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:2877344C>T	ENST00000586426.1	+	4	472	c.385C>T	c.(385-387)Cga>Tga	p.R129*	ZNF556_ENST00000307635.2_Nonsense_Mutation_p.R130*			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGAAAGACTCGAAATTGTAA	0.408000													20	17					0	0	0.007413	0	0
HSD17B2	3294	broad.mit.edu	37	16	82104609	82104609	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:82104609C>T	ENST00000199936.4	+	3	734	c.541C>T	c.(541-543)Ctt>Ttt	p.L181F	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	181					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	GGAGCTTCTTCTTATGACTGA	0.468000													13	48					0	0	0.003163	0	0
HIPK3	10114	broad.mit.edu	37	11	33350174	33350174	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:33350174G>A	ENST00000303296.4	+	3	1521	c.1216G>A	c.(1216-1218)Gat>Aat	p.D406N	HIPK3_ENST00000379016.3_Missense_Mutation_p.D406N|HIPK3_ENST00000534262.1_3'UTR|HIPK3_ENST00000525975.1_Missense_Mutation_p.D406N|HIPK3_ENST00000456517.1_Missense_Mutation_p.D406N	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	406	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						CTTGGAGTATGATCAGGTAAC	0.403000													7	41					0	0	0.001984	0	0
TULP1	7287	broad.mit.edu	37	6	35477635	35477635	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:35477635C>T	ENST00000229771.6	-	6	649	c.570G>A	c.(568-570)gaG>gaA	p.E190E	TULP1_ENST00000322263.4_Silent_p.E137E	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	190					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						TCTTGGTCCCCTCCCCTGCTG	0.572000													53	196					0	0	0.014410	0	0
TMCO4	255104	broad.mit.edu	37	1	20072116	20072116	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:20072116G>A	ENST00000294543.6	-	10	1027	c.786C>T	c.(784-786)gcC>gcT	p.A262A	TMCO4_ENST00000375127.1_Silent_p.A262A|TMCO4_ENST00000375122.2_Intron	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	262						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		ACTCTTCAATGGCTCCCACTC	0.567000													43	121					0	0	0.007835	0	0
USP29	57663	broad.mit.edu	37	19	57641786	57641786	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:57641786G>A	ENST00000254181.4	+	4	2197	c.1743G>A	c.(1741-1743)atG>atA	p.M581I	USP29_ENST00000598197.1_Missense_Mutation_p.M581I	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	581					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CACCATCAATGAAGCTGACCT	0.488000													17	50					0	0	0.004007	0	0
USP44	84101	broad.mit.edu	37	12	95928001	95928001	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:95928001C>T	ENST00000258499.3	-	2	320	c.32G>A	c.(31-33)gGg>gAg	p.G11E	USP44_ENST00000393091.2_Missense_Mutation_p.G11E|USP44_ENST00000552440.1_Missense_Mutation_p.G11E|USP44_ENST00000537435.2_Missense_Mutation_p.G11E	NM_001278393.1|NM_032147.2	NP_001265322.1|NP_115523.2	Q9H0E7	UBP44_HUMAN	ubiquitin specific peptidase 44	11					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(5)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	36						CTGCAGCTGCCCAACATGTTT	0.468000											OREG0022039	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	86					0	0	0.004656	0	0
GPR98	84059	broad.mit.edu	37	5	90074267	90074267	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:90074267G>A	ENST00000405460.2	+	63	12786	c.12690G>A	c.(12688-12690)gaG>gaA	p.E4230E		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4230	Calx-beta 28.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACATTCCCGAGGAAAAAAGCT	0.438000													7	10					0	0	0.001984	0	0
FBXL19	54620	broad.mit.edu	37	16	30958127	30958127	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:30958127C>T	ENST00000338343.4	+	10	2091	c.1704C>T	c.(1702-1704)tcC>tcT	p.S568S	FBXL19_ENST00000471231.2_Silent_p.S276S|FBXL19_ENST00000565690.1_Silent_p.S452S|FBXL19_ENST00000562319.1_Silent_p.S568S|FBXL19_ENST00000380310.2_Silent_p.S588S			Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	588							DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						CAGATGCCTCCCTGCGTCTCC	0.672000													6	18					0	0	0.001168	0	0
SH2D1B	117157	broad.mit.edu	37	1	162368835	162368835	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:162368835C>T	ENST00000367929.2	-	3	350	c.241G>A	c.(241-243)Gaa>Aaa	p.E81K	SH2D1B_ENST00000359567.3_Intron	NM_053282.4	NP_444512.2	O14796	SH21B_HUMAN	SH2 domain containing 1B	81	SH2.									kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			GAGATCAGTTCCTTTAGGCTT	0.408000													35	51					0	0	0.005524	0	0
CNGA1	1259	broad.mit.edu	37	4	47939215	47939215	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:47939215C>T	ENST00000402813.3	-	10	1645	c.1503G>A	c.(1501-1503)aaG>aaA	p.K501K	CNGA1_ENST00000358519.4_Silent_p.K432K|CNGA1_ENST00000420489.2_Silent_p.K432K|CNGA1_ENST00000544810.1_Silent_p.K432K|CNGA1_ENST00000514170.1_Silent_p.K432K			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	432					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity	p.K432N(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						TAATAACCCTCTTTTCCATAT	0.343000													15	61					0	0	0.003163	0	0
TXNRD2	10587	broad.mit.edu	37	22	19865681	19865681	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:19865681C>T	ENST00000535882.1	-	16	1373	c.1374G>A	c.(1372-1374)ctG>ctA	p.L458L	TXNRD2_ENST00000400518.1_Silent_p.L429L|TXNRD2_ENST00000542719.1_Silent_p.L429L|TXNRD2_ENST00000400519.1_Silent_p.L458L|TXNRD2_ENST00000400521.1_Silent_p.L459L|TXNRD2_ENST00000400525.1_Silent_p.L436L			Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2	459					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|urinary_tract(2)	30	Colorectal(54;0.0993)					GGCCCAGCACCAGCTGTGGGG	0.617000													8	23					0	0	0.004482	0	0
ATF2	1386	broad.mit.edu	37	2	175957886	175957886	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:175957886C>T	ENST00000264110.2	-	12	1386	c.1088G>A	c.(1087-1089)aGa>aAa	p.R363K	ATF2_ENST00000409635.1_Missense_Mutation_p.R305K|ATF2_ENST00000409499.1_Intron|ATF2_ENST00000392543.2_Intron|ATF2_ENST00000345739.5_Missense_Mutation_p.R305K|ATF2_ENST00000426833.3_Missense_Mutation_p.R345K|ATF2_ENST00000392544.1_Missense_Mutation_p.R363K|ATF2_ENST00000409437.1_Missense_Mutation_p.R247K|ATF2_ENST00000538946.1_Missense_Mutation_p.R345K|ATF2_ENST00000487334.2_3'UTR	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2	363					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			AGCTGCTGCTCTATTTCGCTC	0.438000													12	40					0	0	0.020292	0	0
STOX2	56977	broad.mit.edu	37	4	184931088	184931088	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:184931088C>T	ENST00000308497.4	+	3	2532	c.1097C>T	c.(1096-1098)tCc>tTc	p.S366F	STOX2_ENST00000438269.1_Missense_Mutation_p.S366F	NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	366					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		CATCGGAAGTCCCATGGAAAG	0.502000													4	19					0	0	0.014758	0	0
PGLYRP4	57115	broad.mit.edu	37	1	153309724	153309724	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:153309724G>A	ENST00000368739.3	-	8	1222	c.864C>T	c.(862-864)gtC>gtT	p.V288V	PGLYRP4_ENST00000359650.5_Silent_p.V292V			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4	292					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGGAGCCTTGGACATTCCAGC	0.547000													7	41					0	0	0.001984	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602718	96602718	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:96602718C>T	ENST00000371321.3	+	7	1168	c.1086C>T	c.(1084-1086)atC>atT	p.I362I	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	362					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TCGACCTCATCCCCACCAGCC	0.537000													21	86					0	0	0.012319	0	0
CST6	1474	broad.mit.edu	37	11	65780821	65780821	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:65780821C>T	ENST00000312134.2	+	3	604	c.400C>T	c.(400-402)Ccc>Tcc	p.P134S		NM_001323.3	NP_001314.1	Q15828	CYTM_HUMAN	cystatin E/M	134					anatomical structure morphogenesis	extracellular region	cysteine-type endopeptidase inhibitor activity			large_intestine(1)|lung(1)|ovary(1)	3						CCTTGTGGTTCCCTGGCAGAA	0.587000													29	90					0	0	0.010818	0	0
MYO3A	53904	broad.mit.edu	37	10	26377279	26377279	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:26377279G>A	ENST00000265944.5	+	15	1673	c.1507G>A	c.(1507-1509)Gga>Aga	p.G503R	MYO3A_ENST00000543632.1_Missense_Mutation_p.G503R	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	503	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGCGGTAGTGGGAGCACAGAT	0.393000													15	35					0	0	0.004990	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439530	150439530	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:150439530G>A	ENST00000358647.3	+	3	670	c.303G>A	c.(301-303)ggG>ggA	p.G101G	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGAACATCGGGGACTGCTACC	0.577000													17	91					0	0	0.007413	0	0
HABP2	3026	broad.mit.edu	37	10	115336971	115336971	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:115336971C>T	ENST00000351270.3	+	5	490	c.394C>T	c.(394-396)Ccc>Tcc	p.P132S	HABP2_ENST00000541666.1_Missense_Mutation_p.P132S|HABP2_ENST00000542051.1_Missense_Mutation_p.P106S|HABP2_ENST00000537906.1_Silent_p.L120L	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	132	EGF-like 2.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		CCAGAGTCCTCCCTACTACCG	0.522000													30	59					0	0	0.007291	0	0
ZNF268	10795	broad.mit.edu	37	12	133779306	133779306	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:133779306C>T	ENST00000536435.2	+	6	1364	c.1034C>T	c.(1033-1035)tCa>tTa	p.S345L	ZNF268_ENST00000536899.2_3'UTR|ZNF268_ENST00000537565.1_Missense_Mutation_p.S184L|ZNF268_ENST00000228289.5_Missense_Mutation_p.S345L|ZNF268_ENST00000542986.2_3'UTR|ZNF268_ENST00000541009.2_3'UTR	NM_001165885.1|NM_003415.2	NP_001159357.1|NP_003406.1	Q14587	ZN268_HUMAN	zinc finger protein 268	345						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(3)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(1)	24	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AGTTTCCATTCACAGCTTGTT	0.398000													7	8					0	0	0.001984	0	0
ZNF716	441234	broad.mit.edu	37	7	57528444	57528444	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:57528444T>A	ENST00000420713.1	+	4	389	c.277T>A	c.(277-279)Ttc>Atc	p.F93I		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						ATGTTCTCATTTCACCCAAGA	0.318000													6	17					0	0	0.001168	0	0
OBSCN	84033	broad.mit.edu	37	1	228487138	228487138	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:228487138G>A	ENST00000570156.2	+	50	13463	c.13389G>A	c.(13387-13389)caG>caA	p.Q4463Q	OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000359599.6_3'UTR|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000422127.1_Intron|RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000366707.4_Silent_p.Q1153Q	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3506	Ig-like 46.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GTGAGCTGCAGATTCATGGCC	0.552000													46	54					0	0	0.014410	0	0
SORCS3	22986	broad.mit.edu	37	10	107015513	107015513	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:107015513G>A	ENST00000369701.3	+	24	3518	c.3291G>A	c.(3289-3291)ctG>ctA	p.L1097L		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1097						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGTTTGAGCTGAAGCCGGGGG	0.448000													15	28					0	0	0.008871	0	0
RPTN	126638	broad.mit.edu	37	1	152129412	152129412	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:152129412C>T	ENST00000316073.3	-	3	227	c.163G>A	c.(163-165)Gaa>Aaa	p.E55K		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	55	EF-hand 2.|S-100-like (By similarity).					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						AAGATGGTTTCCACAGTCTCT	0.418000													18	20					0	0	0.008871	0	0
CEP104	9731	broad.mit.edu	37	1	3746408	3746408	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:3746408T>A	ENST00000378230.3	-	14	2314	c.1990A>T	c.(1990-1992)Att>Ttt	p.I664F		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	664						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						CCCTCAAAAATTGTTTTGTAG	0.438000													47	118					0	0	0.014410	0	0
OPN1SW	611	broad.mit.edu	37	7	128415840	128415840	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:128415840C>T	ENST00000249389.2	-	1	4	c.5G>A	c.(4-6)aGa>aAa	p.R2K		NM_001708.2	NP_001699.1	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	2					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|stomach(1)	19						CGACATTTTTCTCATGGATGC	0.507000													18	26					0	0	0.004990	0	0
DNAJC10	54431	broad.mit.edu	37	2	183605028	183605028	+	Silent	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:183605028T>C	ENST00000264065.6	+	12	1405	c.990T>C	c.(988-990)ttT>ttC	p.F330F		NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	330					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTTTCTAGTTTCTCAACTCAT	0.249000													8	21					0	0	0.003080	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686637	108686637	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:108686637C>T	ENST00000397688.2	-	3	466	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	CMKLR1_ENST00000412676.1_Missense_Mutation_p.E35K|CMKLR1_ENST00000312143.7_Missense_Mutation_p.E35K|CMKLR1_ENST00000550402.1_Missense_Mutation_p.E35K|CMKLR1_ENST00000552995.1_Missense_Mutation_p.E33K	NM_004072.2	NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	35					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						ACCCTGGCTTCCAAGGGGGAT	0.483000													13	30					0	0	0.016723	0	0
CNTNAP3B	728577	broad.mit.edu	37	9	43737504	43737504	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:43737504G>A	ENST00000377564.3	+	3	767	c.374G>A	c.(373-375)cGa>cAa	p.R125Q	CNTNAP3B_ENST00000276974.6_Missense_Mutation_p.R125Q	NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	125	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						CAGTATCGCCGAGAAGAAAGC	0.418000													26	52					0	0	0.019004	0	0
SLC38A4	55089	broad.mit.edu	37	12	47178369	47178369	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:47178369C>T	ENST00000447411.1	-	6	655	c.449G>A	c.(448-450)gGa>gAa	p.G150E	SLC38A4_ENST00000266579.4_Missense_Mutation_p.G150E	NM_001143824.1	NP_001137296.1	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	150					cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					TCCAATTTTTCCCGGCCATCC	0.333000													8	18					0	0	0.006214	0	0
SPTBN5	51332	broad.mit.edu	37	15	42159820	42159820	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:42159820G>A	ENST00000320955.6	-	35	6455	c.6228C>T	c.(6226-6228)gcC>gcT	p.A2076A		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2076					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		AGCTCCCCAAGGCACTGGTTT	0.577000													48	137					0	0	0.014410	0	0
TUB	7275	broad.mit.edu	37	11	8060574	8060574	+	Splice_Site	SNP	C	C	T	rs150936269		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:8060574C>T	ENST00000305253.4	+	1	395	c.155_splice	c.e1+1	p.R52_splice	RP11-236J17.6_ENST00000528151.1_RNA|RP11-236J17.6_ENST00000526646.1_RNA|TUB_ENST00000534099.1_Intron	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	0					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane		p.R52W(1)		breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		CCGAAGAGATCGGTAAGCTTT	0.577000													10	32					0	0	0.006214	0	0
GABRQ	55879	broad.mit.edu	37	X	151821087	151821087	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:151821087C>T	ENST00000370306.2	+	9	1262	c.1242C>T	c.(1240-1242)ctC>ctT	p.L414L		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	414						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					CGGAAAGCCTCGGTTCTTTGA	0.632000													26	17					0	0	0.021523	0	0
PCNXL2	80003	broad.mit.edu	37	1	233386576	233386576	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:233386576C>T	ENST00000258229.8	-	8	2365	c.2131G>A	c.(2131-2133)Gaa>Aaa	p.E711K	PCNXL2_ENST00000430153.1_Missense_Mutation_p.E10K	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	711						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GATCTAATTTCCCCTGTAAAA	0.323000													3	8					0	0	0.004672	0	0
LTBP2	4053	broad.mit.edu	37	14	74969619	74969619	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:74969619C>A	ENST00000261978.4	-	34	5293	c.4907G>T	c.(4906-4908)tGc>tTc	p.C1636F	LTBP2_ENST00000556690.1_Missense_Mutation_p.C1592F	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1636	TB 4.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGCCACGTTGCACAGCTGAGC	0.612000													14	47					4.7546e-09	4.98241e-09	0.004007	1	0
TANGO6	79613	broad.mit.edu	37	16	68901015	68901015	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:68901015C>T	ENST00000261778.1	+	4	898	c.886C>T	c.(886-888)Cgg>Tgg	p.R296W		NM_024562.1	NP_078838.1			transport and golgi organization 6 homolog (Drosophila)																		GATGAGGTGTCGGGCCCCAGC	0.502000													40	87					0	0	0.007835	0	0
NRIP1	8204	broad.mit.edu	37	21	16340213	16340213	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:16340213G>A	ENST00000400202.1	-	3	1013	c.301C>T	c.(301-303)Ctg>Ttg	p.L101L	NRIP1_ENST00000318948.4_Silent_p.L101L|NRIP1_ENST00000400199.1_Silent_p.L101L			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	101	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		GAATCAGACAGCCTCTTCCGC	0.458000													9	29					0	0	0.008291	0	0
CECR6	27439	broad.mit.edu	37	22	17600315	17600315	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:17600315T>C	ENST00000331437.3	-	1	1828	c.1703A>G	c.(1702-1704)tAt>tGt	p.Y568C	CECR6_ENST00000399875.1_Missense_Mutation_p.Y213C	NM_031890.3	NP_114096.1	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	568										haematopoietic_and_lymphoid_tissue(1)	1		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		GGTGTTGACATAGCCATGAGC	0.627000													3	7					0	0	0.004672	0	0
VPS36	51028	broad.mit.edu	37	13	52990024	52990024	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:52990024G>A	ENST00000378060.4	-	14	1129	c.1102C>T	c.(1102-1104)Cgt>Tgt	p.R368C		NM_016075.2	NP_057159.2	Q86VN1	VPS36_HUMAN	vacuolar protein sorting 36 homolog (S. cerevisiae)	368					cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|late endosome|membrane|nucleus	lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	17		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.14e-08)		GAGTCATCACGGCAAAGATGG	0.388000													54	149					0	0	0.014410	0	0
SETD1A	9739	broad.mit.edu	37	16	30995335	30995335	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:30995335C>T	ENST00000262519.8	+	19	5801	c.5115C>T	c.(5113-5115)tcC>tcT	p.S1705S		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	1705	Post-SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						GCCGGGGCTCCCTAAACTGAG	0.612000													7	11					0	0	0.001984	0	0
CTTN	2017	broad.mit.edu	37	11	70275245	70275245	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:70275245G>A	ENST00000301843.8	+	14	1322	c.1116G>A	c.(1114-1116)gaG>gaA	p.E372E	CTTN_ENST00000346329.3_Silent_p.E335E|CTTN_ENST00000376561.3_Silent_p.E335E|CTTN_ENST00000538675.1_Silent_p.E56E	NM_005231.3	NP_005222.2	Q14247	SRC8_HUMAN	cortactin	372						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		CGGAGGCGGAGAGAGCCCAGC	0.597000													10	48					0	0	0.006214	0	0
GFRA1	2674	broad.mit.edu	37	10	117849350	117849350	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:117849350T>A	ENST00000439649.3	-	8	1451	c.1084A>T	c.(1084-1086)Acc>Tcc	p.T362S	GFRA1_ENST00000355422.6_Missense_Mutation_p.T367S|GFRA1_ENST00000369236.1_Missense_Mutation_p.T362S|GFRA1_ENST00000544592.1_Missense_Mutation_p.T246S	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	367	Poly-Thr.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		GCAGTGGTGGTAGTGGCAGTG	0.532000													17	29					0	0	0.004990	0	0
FREM2	341640	broad.mit.edu	37	13	39338470	39338470	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:39338470C>T	ENST00000280481.7	+	3	5509	c.5293C>T	c.(5293-5295)Cgt>Tgt	p.R1765C		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1765	Calx-beta 1.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.R1765C(1)		NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCAGAATTTTCGTCTGAATTG	0.348000													17	47					0	0	0.010504	0	0
PTGER2	5732	broad.mit.edu	37	14	52781928	52781928	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:52781928A>G	ENST00000245457.5	+	1	816	c.662A>G	c.(661-663)aAc>aGc	p.N221S	PTGER2_ENST00000557436.1_Intron	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	221						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	GTCATTCTCAACCTCATCCGC	0.667000													12	33					0	0	0.013537	0	0
ABCC11	85320	broad.mit.edu	37	16	48249135	48249135	+	Missense_Mutation	SNP	C	C	T	rs150392452		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:48249135C>T	ENST00000394747.1	-	7	1421	c.1072G>A	c.(1072-1074)Gag>Aag	p.E358K	ABCC11_ENST00000394748.1_Missense_Mutation_p.E358K|ABCC11_ENST00000537808.1_Missense_Mutation_p.E358K|ABCC11_ENST00000356608.2_Missense_Mutation_p.E358K|ABCC11_ENST00000353782.5_Missense_Mutation_p.E358K	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	358	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				AATGGTTTCTCCCATGTGTAC	0.478000													11	43					0	0	0.010729	0	0
SHBG	6462	broad.mit.edu	37	17	7536267	7536267	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:7536267G>A	ENST00000380450.4	+	7	1081	c.1050G>A	c.(1048-1050)ggG>ggA	p.G350G	SHBG_ENST00000340624.5_Intron|SHBG_ENST00000575314.1_Silent_p.G292G|SHBG_ENST00000576478.1_Intron|SHBG_ENST00000575903.1_Silent_p.G332G|SHBG_ENST00000572262.1_Silent_p.G238G|SHBG_ENST00000441599.2_Intron|SHBG_ENST00000572182.1_Intron|SHBG_ENST00000576728.1_Intron|SHBG_ENST00000574539.1_Intron|SHBG_ENST00000416273.3_Intron|SHBG_ENST00000570547.1_Intron	NM_001040.3	NP_001031.2	P04278	SHBG_HUMAN	sex hormone-binding globulin	350	Laminin G-like 2.				hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.0?(1)|p.?(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	TCTTCCTGGGGGCTTTACCAG	0.557000											OREG0024140	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	15					0	0	0.010729	0	0
CD109	135228	broad.mit.edu	37	6	74497110	74497110	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:74497110C>T	ENST00000437994.2	+	21	2922	c.2491C>T	c.(2491-2493)Cct>Tct	p.P831S	CD109_ENST00000287097.5_Missense_Mutation_p.P831S|CD109_ENST00000422508.2_Missense_Mutation_p.P754S	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	831						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GGGAGAAATTCCTATCACAGT	0.448000													21	20					0	0	0.014323	0	0
RSPH10B	222967	broad.mit.edu	37	7	5966180	5966180	+	Splice_Site	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:5966180C>T	ENST00000405415.1	-	20	2819		c.e20-1		RSPH10B_ENST00000404406.1_Splice_Site|RSPH10B_ENST00000539903.1_Splice_Site|RSPH10B_ENST00000337579.3_Splice_Site|RSPH10B_ENST00000441023.2_Splice_Site			B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B (Chlamydomonas)											breast(1)|kidney(1)|lung(4)|ovary(1)|skin(4)	11		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0974)		GATGTTCAGCCTAAAAGCAAA	0.453000													24	43					0	0	0.004656	0	0
TPPP3	51673	broad.mit.edu	37	16	67424844	67424844	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:67424844G>A	ENST00000564104.1	-	1	1012	c.171C>T	c.(169-171)atC>atT	p.I57I	TPPP3_ENST00000562206.1_Silent_p.I57I|TPPP3_ENST00000290942.5_Silent_p.I57I|TPPP3_ENST00000393957.2_Silent_p.I57I			Q9BW30	TPPP3_HUMAN	tubulin polymerization-promoting protein family member 3	57					microtubule bundle formation	cytoplasm|microtubule	calcium ion binding|tubulin binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)	7		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0336)|Epithelial(162;0.0781)		TGGAGAAGACGATGTCCACAT	0.577000													10	26					0	0	0.010729	0	0
HSF4	3299	broad.mit.edu	37	16	67197714	67197714	+	Translation_Start_Site	SNP	C	C	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:67197714C>A	ENST00000264009.8	+	0	427				RP11-5A19.5_ENST00000580114.1_Missense_Mutation_p.R143S|HSF4_ENST00000421453.1_De_novo_Start_OutOfFrame|FBXL8_ENST00000258200.3_Silent_p.L372L|FBXL8_ENST00000519917.1_Silent_p.L372L|RP11-5A19.5_ENST00000518753.1_3'UTR	NM_001040667.2	NP_001035757.1	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4						response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		GGCCTACGCTCGTGGCGTGAT	0.697000													11	35					3.27435e-08	3.42066e-08	0.020292	1	0
GPR112	139378	broad.mit.edu	37	X	135427812	135427812	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:135427812C>T	ENST00000394143.1	+	6	2238	c.1947C>T	c.(1945-1947)ttC>ttT	p.F649F	GPR112_ENST00000412101.1_Silent_p.F444F|GPR112_ENST00000394141.1_Silent_p.F444F|GPR112_ENST00000370652.1_Silent_p.F649F|GPR112_ENST00000287534.4_Silent_p.F586F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	649					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CCCATCTGTTCTCCAGCAATG	0.473000													4	5					0	0	0.014758	0	0
ACRBP	84519	broad.mit.edu	37	12	6747518	6747518	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:6747518C>T	ENST00000229243.2	-	10	1655	c.1562G>A	c.(1561-1563)gGc>gAc	p.G521D	ACRBP_ENST00000414226.2_Missense_Mutation_p.G488D	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	521						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						CTCACTTTTGCCAGGGCTCAG	0.562000													22	54					0	0	0.014323	0	0
ROR2	4920	broad.mit.edu	37	9	94486585	94486585	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:94486585C>T	ENST00000375708.3	-	9	2389	c.2191G>A	c.(2191-2193)Gag>Aag	p.E731K	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Missense_Mutation_p.E591K	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	731	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding	p.E731K(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CTGGGGAACTCGTTCCAGCAC	0.647000													23	67					0	0	0.014323	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209950711	209950711	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:209950711G>A	ENST00000367024.1	+	12	1584	c.1068G>A	c.(1066-1068)agG>agA	p.R356R	TRAF3IP3_ENST00000477431.1_Silent_p.R92R|TRAF3IP3_ENST00000010338.4_Silent_p.R336R|TRAF3IP3_ENST00000367023.1_Silent_p.R92R|TRAF3IP3_ENST00000400959.3_Silent_p.R336R|TRAF3IP3_ENST00000367025.3_Silent_p.R356R|TRAF3IP3_ENST00000367026.3_Silent_p.R336R			Q9Y228	T3JAM_HUMAN	TRAF3 interacting protein 3	356						integral to membrane	protein binding			breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		CAGATAGCAGGGACTTACAGA	0.537000													15	64					0	0	0.004007	0	0
DAB1	1600	broad.mit.edu	37	1	57537993	57537993	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:57537993C>T	ENST00000371236.2	-	5	664	c.401G>A	c.(400-402)gGg>gAg	p.G134E	DAB1_ENST00000414851.2_Missense_Mutation_p.G134E|DAB1_ENST00000439789.2_Intron|DAB1_ENST00000371234.4_Missense_Mutation_p.G134E|DAB1_ENST00000371230.1_Missense_Mutation_p.G134E|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000371231.1_Missense_Mutation_p.G134E|DAB1_ENST00000420954.2_Missense_Mutation_p.G134E			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	134	PID.				cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						TCTGTGATTCCCTTCCTTCCC	0.478000													8	28					0	0	0.008291	0	0
NRXN1	9378	broad.mit.edu	37	2	50724508	50724508	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:50724508C>T	ENST00000404971.1	-	15	4301	c.2962G>A	c.(2962-2964)Gat>Aat	p.D988N	NRXN1_ENST00000401669.2_Missense_Mutation_p.D948N|NRXN1_ENST00000406859.3_Missense_Mutation_p.D948N|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000402717.3_Missense_Mutation_p.D940N|NRXN1_ENST00000406316.2_Missense_Mutation_p.D948N|NRXN1_ENST00000405472.3_Missense_Mutation_p.D940N	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	948	Laminin G-like 5.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TCATTTCCATCCCCACTGTTA	0.358000													10	26					0	0	0.008291	0	0
NOP2	4839	broad.mit.edu	37	12	6669901	6669901	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:6669901C>T	ENST00000541778.1	-	13	1876	c.1388G>A	c.(1387-1389)gGg>gAg	p.G463E	NOP2_ENST00000399466.2_Missense_Mutation_p.G463E|NOP2_ENST00000537442.1_Missense_Mutation_p.G467E|NOP2_ENST00000322166.5_Missense_Mutation_p.G467E|NOP2_ENST00000545200.1_Missense_Mutation_p.G463E|NOP2_ENST00000382421.3_Missense_Mutation_p.G500E|NOP2_ENST00000542015.1_5'UTR			P46087	NOP2_HUMAN	NOP2 nucleolar protein	467					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	19						GGAGATGACCCCAGTGCCACT	0.557000													3	26					0	0	0.009096	0	0
ZNF620	253639	broad.mit.edu	37	3	40558019	40558019	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:40558019G>A	ENST00000314529.6	+	5	1083	c.934G>A	c.(934-936)Gaa>Aaa	p.E312K	ZNF620_ENST00000418905.1_Missense_Mutation_p.E198K	NM_175888.3	NP_787084.1	Q6ZNG0	ZN620_HUMAN	zinc finger protein 620	312					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(1)|urinary_tract(1)	11				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		TGAATGTAACGAATGTTGGAA	0.473000													19	47					0	0	0.007413	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21794027	21794027	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:21794027G>A	ENST00000206660.6	+	16	2405	c.2405G>A	c.(2404-2406)tGg>tAg	p.W802*	RPGRIP1_ENST00000307974.4_Nonsense_Mutation_p.W161*|RPGRIP1_ENST00000557771.1_Nonsense_Mutation_p.W764*|RPGRIP1_ENST00000400017.2_Nonsense_Mutation_p.W802*|RPGRIP1_ENST00000556336.1_Intron|RPGRIP1_ENST00000382933.4_Intron			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	802	C2.				response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		AACGAGCTGTGGATTGAAATC	0.507000													10	24					0	0	0.010729	0	0
OR4M1	441670	broad.mit.edu	37	14	20249248	20249248	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:20249248C>T	ENST00000315957.4	+	1	848	c.767C>T	c.(766-768)tCc>tTc	p.S256F		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTGGGCCATCCATCTACATT	0.423000													15	93					0	0	0.003163	0	0
TRBC2	28638	broad.mit.edu	37	7	142499006	142499006	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:142499006C>T	ENST00000466254.1	+	0	282																											CAACCACTTCCGCTGTCAAGT	0.632000													29	99					0	0	0.009535	0	0
ZFP36L1	677	broad.mit.edu	37	14	69262645	69262645	+	Silent	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:69262645G>T	ENST00000408913.2	-	1	545	c.367C>A	c.(367-369)Cga>Aga	p.R123R				Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	0					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AGACGTGGTCGACAGGTGCCC	0.751000													8	18					0.00307968	0.0031757	0.003080	1	0
ZBTB7C	201501	broad.mit.edu	37	18	45567077	45567077	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:45567077C>T	ENST00000588982.1	-	3	903	c.402G>A	c.(400-402)ggG>ggA	p.G134G	ZBTB7C_ENST00000332053.2_Silent_p.G134G|ZBTB7C_ENST00000590800.1_Silent_p.G134G|ZBTB7C_ENST00000535628.2_Silent_p.G134G|ZBTB7C_ENST00000586438.1_Silent_p.G134G			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	134	Asp-rich.|Glu-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						catcctcctcccccccgtccc	0.572000													9	25					0	0	0.004482	0	0
SERPINB9	5272	broad.mit.edu	37	6	2900804	2900804	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:2900804G>A	ENST00000380698.4	-	2	131	c.42C>T	c.(40-42)cgC>cgT	p.R14R		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	14					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TCTTTAAAAGGCGTATGGCAA	0.473000													88	148					0	0	0.014410	0	0
ZFHX3	463	broad.mit.edu	37	16	72993158	72993158	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:72993158G>A	ENST00000268489.5	-	2	1559	c.887C>T	c.(886-888)tCg>tTg	p.S296L	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	296					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GGTCACAAACGAACGGACGTA	0.493000													19	60					0	0	0.007413	0	0
DLL4	54567	broad.mit.edu	37	15	41229024	41229024	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:41229024G>A	ENST00000249749.5	+	9	2115	c.1839G>A	c.(1837-1839)ttG>ttA	p.L613L		NM_019074.3	NP_061947.1	Q9NR61	DLL4_HUMAN	delta-like 4 (Drosophila)	613					blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(3)|large_intestine(1)	4		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		ACCACACATTGGACTATAATC	0.557000													21	41					0	0	0.014323	0	0
PRB2	653247	broad.mit.edu	37	12	11546281	11546281	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:11546281C>T	ENST00000389362.4	-	3	766	c.731G>A	c.(730-732)gGa>gAa	p.G244E	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGGGGTGGTCCTTGTGGCTT	0.602000													75	337					0	0	0.014410	0	0
SCN11A	11280	broad.mit.edu	37	3	38936058	38936058	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:38936058G>A	ENST00000302328.3	-	15	2999	c.2801C>T	c.(2800-2802)gCa>gTa	p.A934V	SCN11A_ENST00000456224.3_Missense_Mutation_p.A934V|SCN11A_ENST00000444237.2_Missense_Mutation_p.A934V|SCN11A_ENST00000450244.1_Missense_Mutation_p.A934V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	934					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GATGCGCTGTGCATTATCTTC	0.488000													43	127					0	0	0.014410	0	0
USP19	10869	broad.mit.edu	37	3	49156456	49156456	+	Splice_Site	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:49156456T>C	ENST00000453664.1	-	2	441	c.124_splice	c.e2+1	p.K41_splice	USP19_ENST00000488993.1_5'UTR|USP19_ENST00000417901.1_Splice_Site_p.K41_splice|USP19_ENST00000398892.3_Splice_Site_p.K41_splice|USP19_ENST00000398898.2_Splice_Site_p.K41_splice|USP19_ENST00000434032.2_Splice_Site_p.K41_splice|USP19_ENST00000398888.2_Splice_Site_p.K41_splice	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	41					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CACTCCCACCTTTCCTAGGAT	0.517000													26	108					0	0	0.008361	0	0
MYRIP	25924	broad.mit.edu	37	3	40231917	40231917	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:40231917C>T	ENST00000302541.6	+	10	1970	c.1628C>T	c.(1627-1629)tCc>tTc	p.S543F	MYRIP_ENST00000396217.3_Missense_Mutation_p.S454F|MYRIP_ENST00000444716.1_Missense_Mutation_p.S543F|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000539167.1_Missense_Mutation_p.S356F|MYRIP_ENST00000425621.1_Missense_Mutation_p.S543F	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	543	Actin-binding.|Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GAACCATCTTCCCCCAGCGCC	0.597000													16	30					0	0	0.004990	0	0
NIPBL	25836	broad.mit.edu	37	5	37006515	37006515	+	Silent	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:37006515T>A	ENST00000282516.8	+	17	4411	c.3912T>A	c.(3910-3912)gtT>gtA	p.V1304V	NIPBL_ENST00000448238.2_Silent_p.V1304V	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	1304					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TGGAGAGAGTTACAAAATCAG	0.333000													14	19					0	0	0.004007	0	0
SLC1A7	6512	broad.mit.edu	37	1	53558435	53558435	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:53558435G>A	ENST00000371494.4	-	7	949	c.822C>T	c.(820-822)ttC>ttT	p.F274F		NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7	274						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	CCGCAATGAGGAACACAATGC	0.667000													23	63					0	0	0.018920	0	0
FGF10	2255	broad.mit.edu	37	5	44305142	44305142	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:44305142C>T	ENST00000264664.4	-	3	696	c.582G>A	c.(580-582)agG>agA	p.R194R		NM_004465.1	NP_004456.1	O15520	FGF10_HUMAN	fibroblast growth factor 10	194					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			haematopoietic_and_lymphoid_tissue(1)|lung(11)|skin(1)	13	Lung NSC(6;1.12e-06)					AGGTGTTTTTCCTTCGTGTTT	0.438000													10	50					0	0	0.006214	0	0
NNT	23530	broad.mit.edu	37	5	43628344	43628344	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:43628344C>T	ENST00000264663.5	+	7	1040	c.819C>T	c.(817-819)ccC>ccT	p.P273P	NNT_ENST00000512996.2_Silent_p.P142P|NNT_ENST00000344920.4_Silent_p.P273P	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	273					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	GTGCTGAGCCCTTGGAGGTGG	0.433000													15	64					0	0	0.003163	0	0
SIRPG	55423	broad.mit.edu	37	20	1629916	1629916	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:1629916C>T	ENST00000381580.1	-	2	292	c.113G>A	c.(112-114)gGa>gAa	p.G38E	SIRPG_ENST00000344103.4_Missense_Mutation_p.G71E|SIRPG_ENST00000381583.2_Missense_Mutation_p.G71E|SIRPG_ENST00000216927.4_Missense_Mutation_p.G71E|SIRPG_ENST00000303415.3_Missense_Mutation_p.G71E			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	71	Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						CCGGCCTGGTCCAACTCCTCT	0.512000													16	53					0	0	0.006122	0	0
WRNIP1	56897	broad.mit.edu	37	6	2784557	2784557	+	Splice_Site	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:2784557G>T	ENST00000380769.4	+	6	1213		c.e6-1		WRNIP1_ENST00000380773.4_Splice_Site|WRNIP1_ENST00000380764.1_Splice_Site|WRNIP1_ENST00000380771.4_Splice_Site			Q96S55	WRIP1_HUMAN	Werner helicase interacting protein 1						DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				GTGTGTGGCAGGTCTGGCAGA	0.507000													13	19					1.15088e-07	1.20138e-07	0.004007	1	0
LIN54	132660	broad.mit.edu	37	4	83905883	83905883	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:83905883G>A	ENST00000340417.3	-	2	492	c.115C>T	c.(115-117)Ccc>Tcc	p.P39S	LIN54_ENST00000505397.1_Missense_Mutation_p.P39S|LIN54_ENST00000446851.2_Intron|LIN54_ENST00000442461.2_Intron|LIN54_ENST00000395283.2_Missense_Mutation_p.P39S|LIN54_ENST00000506560.1_Missense_Mutation_p.P39S|LIN54_ENST00000395282.2_Missense_Mutation_p.P39S|LIN54_ENST00000510557.1_Intron	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 homolog (C. elegans)	39					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)	14		Hepatocellular(203;0.114)				GTCTCCATGGGAATTGGGGAT	0.418000													17	58					0	0	0.004990	0	0
USP54	159195	broad.mit.edu	37	10	75289602	75289602	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:75289602G>A	ENST00000339859.4	-	14	1996	c.1896C>T	c.(1894-1896)agC>agT	p.S632S	USP54_ENST00000428547.1_Silent_p.S482S|USP54_ENST00000497106.1_5'UTR|USP54_ENST00000394811.2_5'UTR|USP54_ENST00000319786.7_Silent_p.S632S|USP54_ENST00000408019.1_Silent_p.S632S			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	632					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					TGTACTGGGGGCTTGGTCCAC	0.488000											OREG0020266	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	100					0	0	0.012213	0	0
IGDCC4	57722	broad.mit.edu	37	15	65676528	65676528	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:65676528G>A	ENST00000352385.2	-	20	3781	c.3572C>T	c.(3571-3573)gCc>gTc	p.A1191V	IGDCC4_ENST00000558048.1_5'UTR	NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1191						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						TGGCCCGGGGGCTGCCAGCTC	0.667000													10	22					0	0	0.006214	0	0
DHX36	170506	broad.mit.edu	37	3	153998449	153998449	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:153998449T>A	ENST00000496811.1	-	22	2566	c.2486A>T	c.(2485-2487)aAg>aTg	p.K829M	DHX36_ENST00000308361.6_Missense_Mutation_p.K800M|DHX36_ENST00000544526.1_Missense_Mutation_p.K815M|DHX36_ENST00000329463.5_Missense_Mutation_p.K815M	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	829						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTTAATTATCTTCTCATTATC	0.323000													24	78					0	0	0.004656	0	0
OPTC	26254	broad.mit.edu	37	1	203467944	203467944	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:203467944G>A	ENST00000367222.2	+	4	622	c.506G>A	c.(505-507)aGg>aAg	p.R169K		NM_014359.3	NP_055174.1	Q9UBM4	OPT_HUMAN	opticin	169						proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			breast(1)|cervix(1)|kidney(5)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)	20			BRCA - Breast invasive adenocarcinoma(75;0.109)			AGCCGTATCAGGGCCGAAGAC	0.542000													10	69					0	0	0.010729	0	0
CHAD	1101	broad.mit.edu	37	17	48545403	48545403	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:48545403T>A	ENST00000508540.1	-	1	924	c.772A>T	c.(772-774)Aag>Tag	p.K258*	ACSF2_ENST00000300441.4_Intron|ACSF2_ENST00000541920.1_Intron|ACSF2_ENST00000427954.2_Intron|CHAD_ENST00000258969.4_Nonsense_Mutation_p.K258*|ACSF2_ENST00000502667.1_Intron|ACSF2_ENST00000504392.1_Intron	NM_001267.2	NP_001258.2	O15335	CHAD_HUMAN	chondroadherin	258					regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(2)|ovary(2)	15	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GAGCTCACCTTCTCCAGGTTG	0.622000													43	42					0	0	0.009718	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	73938417	73938417	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:73938417C>T	ENST00000476977.1	+	8	2714	c.1023C>T	c.(1021-1023)ttC>ttT	p.F341F	GTF2IRD1_ENST00000424337.2_Silent_p.F341F|GTF2IRD1_ENST00000489094.1_3'UTR|GTF2IRD1_ENST00000265755.3_Silent_p.F341F|GTF2IRD1_ENST00000455841.2_Silent_p.F373F			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	341						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GGGACGCCTTCATAAAGGAAA	0.612000													4	15					0	0	0.009096	0	0
CR1	1378	broad.mit.edu	37	1	207751155	207751155	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:207751155C>T	ENST00000367049.4	+	29	4543	c.4543C>T	c.(4543-4545)Cct>Tct	p.P1515S	RP11-78B10.2_ENST00000597497.1_RNA|CR1_ENST00000367052.1_Missense_Mutation_p.P1065S|CR1_ENST00000367051.1_Missense_Mutation_p.P1065S|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367053.1_Missense_Mutation_p.P1065S|CR1_ENST00000400960.2_Missense_Mutation_p.P1065S	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1065	Sushi 23.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TCCAGGAATTCCTTGTGGGCT	0.483000													13	11					0	0	0.013537	0	0
ABCC4	10257	broad.mit.edu	37	13	95726485	95726485	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:95726485G>A	ENST00000376887.4	-	23	3014	c.2900C>T	c.(2899-2901)tCc>tTc	p.S967F	ABCC4_ENST00000412704.1_Missense_Mutation_p.S920F	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	967	ABC transmembrane type-1 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CAGAATCAGGGACCCAAAGGC	0.413000													6	22					0	0	0.001984	0	0
SAMD9	54809	broad.mit.edu	37	7	92731787	92731787	+	Silent	SNP	G	G	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:92731787G>T	ENST00000379958.2	-	3	3893	c.3624C>A	c.(3622-3624)atC>atA	p.I1208I		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1208						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GGAGAATTTGGATTGTGTAAA	0.348000													20	50					7.45023e-12	7.84965e-12	0.010504	1	0
NOTCH4	4855	broad.mit.edu	37	6	32182030	32182030	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:32182030G>A	ENST00000375023.3	-	13	2162	c.2024C>T	c.(2023-2025)tCc>tTc	p.S675F		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	675	EGF-like 17.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						CACACATGAGGATCTGGTTGT	0.577000													138	507					0	0	0.014410	0	0
KL	9365	broad.mit.edu	37	13	33628071	33628071	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:33628071A>G	ENST00000380099.3	+	2	995	c.987A>G	c.(985-987)aaA>aaG	p.K329K	KL_ENST00000426690.2_Silent_p.K22K|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	329	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GGTTTGCCAAACCCGTATTTA	0.403000													18	62					0	0	0.007413	0	0
CUX2	23316	broad.mit.edu	37	12	111758289	111758289	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:111758289C>T	ENST00000261726.6	+	17	2630	c.2476C>T	c.(2476-2478)Cgc>Tgc	p.R826C		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	826						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CGCCTGGCCCCGCGGGGACGA	0.771000													3	15					0	0	0.004672	0	0
ZNF425	155054	broad.mit.edu	37	7	148802164	148802164	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:148802164C>T	ENST00000378061.2	-	4	931	c.799G>A	c.(799-801)Gtc>Atc	p.V267I		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	267					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CCGGTGTGGACAACCTGATGA	0.612000													14	65					0	0	0.016723	0	0
TTN	7273	broad.mit.edu	37	2	179612157	179612157	+	Silent	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:179612157T>G	ENST00000360870.5	-	46	15192	c.14970A>C	c.(14968-14970)ccA>ccC	p.P4990P	TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000578746.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	1099	Ig-like 30.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGATGATGGTGGGGTATAAA	0.378000													3	10					0	0	0.004672	0	0
MUC5B	727897	broad.mit.edu	37	11	1263670	1263670	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:1263670G>A	ENST00000447027.1	+	31	5627	c.5569G>A	c.(5569-5571)Ggg>Agg	p.G1857R	MUC5B_ENST00000529681.1_Missense_Mutation_p.G1854R|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1854	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCTGGAGACGGGGCTGACCTG	0.592000													12	36					0	0	0.010729	0	0
SEC14L4	284904	broad.mit.edu	37	22	30887647	30887647	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:30887647C>T	ENST00000392772.2	-	11	1109	c.832G>A	c.(832-834)Gag>Aag	p.E278K	SEC14L4_ENST00000540456.1_Missense_Mutation_p.E317K|SEC14L4_ENST00000381982.3_Missense_Mutation_p.E332K|SEC14L4_ENST00000255858.7_Missense_Mutation_p.E332K			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	332	GOLD.					integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	TCCGTCATCTCCCTAGCACTC	0.607000													30	93					0	0	0.010818	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801540	185801540	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:185801540C>T	ENST00000302277.6	+	4	2011	c.1417C>T	c.(1417-1419)Cta>Tta	p.L473L		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	473						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAATAATAATCTAGATAAAAA	0.348000													6	27					0	0	0.001168	0	0
DGKI	9162	broad.mit.edu	37	7	137293795	137293795	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:137293795G>A	ENST00000453654.1	-	10	723	c.184C>T	c.(184-186)Cgt>Tgt	p.R62C	DGKI_ENST00000288490.5_Missense_Mutation_p.R362C|DGKI_ENST00000446122.1_Missense_Mutation_p.R362C|DGKI_ENST00000424189.2_Missense_Mutation_p.R362C			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	362					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						ACAAAAGGACGACCTTTGTTT	0.453000													3	11					0	0	0.009096	0	0
FPGS	2356	broad.mit.edu	37	9	130569923	130569923	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:130569923G>A	ENST00000373245.1	+	8	750	c.700G>A	c.(700-702)Gat>Aat	p.D234N	FPGS_ENST00000373247.2_Missense_Mutation_p.D234N|FPGS_ENST00000373225.3_Missense_Mutation_p.D184N|FPGS_ENST00000393706.2_Missense_Mutation_p.D208N|FPGS_ENST00000460181.1_3'UTR			Q05932	FOLC_HUMAN	folylpolyglutamate synthase	234					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity	p.D234N(1)		endometrium(2)|kidney(1)|lung(3)|ovary(1)	7					L-Glutamic Acid(DB00142)	CCTCCTGGGGGATACGGTGGA	0.602000													7	42					0	0	0.003080	0	0
OSBP	5007	broad.mit.edu	37	11	59368079	59368079	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:59368079T>A	ENST00000263847.1	-	7	1680	c.1201A>T	c.(1201-1203)Acc>Tcc	p.T401S		NM_002556.2	NP_002547.1	P22059	OSBP1_HUMAN	oxysterol binding protein	401					lipid transport	Golgi membrane	oxysterol binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TCCTTTTTGGTCTCCTCCAGC	0.418000													16	38					0	0	0.004990	0	0
OR4D9	390199	broad.mit.edu	37	11	59282709	59282709	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:59282709G>A	ENST00000329328.3	+	1	324	c.324G>A	c.(322-324)ggG>ggA	p.G108G		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						ACCTTCTGGGGGGAGCAGACG	0.488000													17	64					0	0	0.004990	0	0
HS3ST2	9956	broad.mit.edu	37	16	22926572	22926572	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:22926572C>T	ENST00000261374.3	+	2	1227	c.793C>T	c.(793-795)Ccg>Tcg	p.P265S		NM_006043.1	NP_006034.1	Q9Y278	HS3S2_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	265						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity	p.P265S(1)		breast(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(2)|skin(1)	19				GBM - Glioblastoma multiforme(48;0.0299)		GCAGTACTTCCCGCTAGCTCA	0.607000													54	135					0	0	0.014410	0	0
MYF6	4618	broad.mit.edu	37	12	81101549	81101549	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:81101549G>A	ENST00000228641.3	+	1	273	c.51G>A	c.(49-51)ggG>ggA	p.G17G		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	17					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity	p.G17G(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						ACTTGGATGGGGAAAATGTTA	0.502000													12	74					0	0	0.003163	0	0
HBB	3043	broad.mit.edu	37	11	5247936	5247936	+	Silent	SNP	C	C	T	rs34446260		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:5247936C>T	ENST00000335295.3	-	2	361	c.186G>A	c.(184-186)aaG>aaA	p.K62K		NM_000518.4	NP_000509.1	P68871	HBB_HUMAN	hemoglobin, beta	62			K -> E (in N-Seatlle).|K -> M (in Bologna; O(2) affinity down).|K -> N (in Hikari).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)	15		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	TGCCATGAGCCTTCACCTTAG	0.552000									Sickle Cell Trait				22	73					0	0	0.018920	0	0
OR4K2	390431	broad.mit.edu	37	14	20345185	20345185	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:20345185A>G	ENST00000298642.2	+	1	795	c.759A>G	c.(757-759)ccA>ccG	p.P253P		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTTGGGCCATGCATCTTCA	0.418000													22	71					0	0	0.014323	0	0
FREM2	341640	broad.mit.edu	37	13	39264353	39264353	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr13:39264353G>A	ENST00000280481.7	+	1	3088	c.2872G>A	c.(2872-2874)Gaa>Aaa	p.E958K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	958					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AGATGTCTTAGAAAATGGGGC	0.463000													12	37					0	0	0.013537	0	0
FAT4	79633	broad.mit.edu	37	4	126238981	126238981	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:126238981C>T	ENST00000394329.3	+	1	1428	c.1415C>T	c.(1414-1416)cCt>cTt	p.P472L		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	472	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AATGACCATCCTCCTGTCTTT	0.557000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	27					0	0	0.008291	0	0
PAPPA2	60676	broad.mit.edu	37	1	176809372	176809372	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:176809372G>A	ENST00000367662.3	+	22	6430	c.5266G>A	c.(5266-5268)Gga>Aga	p.G1756R		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1756					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CTATGACGGGGGAGACTGCTG	0.542000													9	74					0	0	0.013537	0	0
NBEAL2	23218	broad.mit.edu	37	3	47043884	47043884	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:47043884C>T	ENST00000450053.3	+	32	5354	c.5175C>T	c.(5173-5175)ttC>ttT	p.F1725F	NBEAL2_ENST00000383740.2_Silent_p.F4F|NBEAL2_ENST00000292309.5_Silent_p.F1541F	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1725							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TGTCCCAGTTCGAAATGGACA	0.582000													19	74					0	0	0.018920	0	0
TMEM178A	130733	broad.mit.edu	37	2	39931305	39931305	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:39931305C>T	ENST00000281961.2	+	2	541	c.485C>T	c.(484-486)aCc>aTc	p.T162I	TMEM178A_ENST00000482239.1_3'UTR	NM_152390.2	NP_689603.2			transmembrane protein 178A																		TTAACCAAGACCATACAGCAA	0.458000													8	32					0	0	0.004482	0	0
TMEM117	84216	broad.mit.edu	37	12	44782223	44782223	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:44782223C>T	ENST00000266534.3	+	8	1440	c.1313C>T	c.(1312-1314)tCt>tTt	p.S438F	TMEM117_ENST00000536799.1_Missense_Mutation_p.S334F|TMEM117_ENST00000551577.1_3'UTR|TMEM117_ENST00000546978.1_3'UTR	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	438						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		AAAAGAAAATCTCCATCAGAA	0.413000													4	18					0	0	0.009096	0	0
IL9R	3581	broad.mit.edu	37	X	155239703	155239703	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:155239703G>A	ENST00000424344.3	+	10	1499	c.1132G>A	c.(1132-1134)Gag>Aag	p.E378K	IL9R_ENST00000540897.1_3'UTR|IL9R_ENST00000369423.2_3'UTR|IL9R_ENST00000244174.5_Missense_Mutation_p.E399K			Q01113	IL9R_HUMAN	interleukin 9 receptor	399					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AGGGTGTACGGAGTGGAGGGT	0.652000													11	25					0	0	0.003163	0	0
HIST1H3D	8351	broad.mit.edu	37	6	26197197	26197197	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:26197197C>T	ENST00000377831.5	-	2	735	c.282G>A	c.(280-282)caG>caA	p.Q94Q	HIST1H3D_ENST00000356476.2_Silent_p.Q94Q	NM_003530.3	NP_003521.2	P68431	H31_HUMAN	histone cluster 1, H3d	94					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)	14		all_hematologic(11;0.196)				CGCAGGCCTCCTGCAGCGCCA	0.577000													48	75					0	0	0.014410	0	0
KMT2D	8085	broad.mit.edu	37	12	49428389	49428389	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:49428389G>A	ENST00000301067.7	-	36	10415	c.10416C>T	c.(10414-10416)aaC>aaT	p.N3472N		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CTGCCACATGGTTCTGCAGAT	0.552000													4	14					0	0	0.009096	0	0
AGBL2	79841	broad.mit.edu	37	11	47701582	47701582	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:47701582G>A	ENST00000525123.1	-	13	2244	c.1959C>T	c.(1957-1959)tcC>tcT	p.S653S	AGBL2_ENST00000298861.4_Silent_p.S653S|AGBL2_ENST00000529712.1_5'UTR|AGBL2_ENST00000528244.1_Silent_p.S615S|AGBL2_ENST00000357610.3_Silent_p.S653S	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2	653					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						GATAACCTAAGGACTTCAGAT	0.393000													14	53					0	0	0.004007	0	0
GPR45	11250	broad.mit.edu	37	2	105859056	105859056	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:105859056G>A	ENST00000258456.1	+	1	857	c.741G>A	c.(739-741)cgG>cgA	p.R247R		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	247						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						CGGGCCTGCGGCGCCTGCAGC	0.642000													43	87					0	0	0.014410	0	0
HTR3D	200909	broad.mit.edu	37	3	183756207	183756207	+	Silent	SNP	C	C	T	rs139778852		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:183756207C>T	ENST00000382489.3	+	7	930	c.930C>T	c.(928-930)ttC>ttT	p.F310F	HTR3D_ENST00000453435.1_Silent_p.F89F|HTR3D_ENST00000428798.2_Silent_p.F260F|HTR3D_ENST00000334128.2_Silent_p.F135F	NM_001163646.1	NP_001157118.1	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	310						integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)	10	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GTGTCTACTTCGCCCTGTGCC	0.587000													25	60					0	0	0.006320	0	0
USP25	29761	broad.mit.edu	37	21	17183476	17183476	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:17183476A>G	ENST00000285681.2	+	9	1247	c.878A>G	c.(877-879)aAc>aGc	p.N293S	USP25_ENST00000400183.2_Missense_Mutation_p.N293S|USP25_ENST00000285679.6_Missense_Mutation_p.N293S|USP25_ENST00000547201.1_3'UTR|USP25_ENST00000351097.5_Intron			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	293					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AAGCCAAAGAACCCCATGGTA	0.318000													20	53					0	0	0.016522	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274416	39274416	+	Missense_Mutation	SNP	C	C	T	rs408579	by1000genomes	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:39274416C>T	ENST00000391413.2	-	1	190	c.152G>A	c.(151-153)aGg>aAg	p.R51K		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	51	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament		p.R51K(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCACTGGGGCCTGCAGCAGCT	0.672000													5	82					0	0	0.001984	0	0
SI	6476	broad.mit.edu	37	3	164750406	164750406	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:164750406G>A	ENST00000264382.3	-	24	2702	c.2640C>T	c.(2638-2640)atC>atT	p.I880I		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	880	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCAACCCAAGGATTTTTACAG	0.353000										HNSCC(35;0.089)			6	7					0	0	0.001168	0	0
HAPLN1	1404	broad.mit.edu	37	5	82948507	82948507	+	Silent	SNP	A	A	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:82948507A>G	ENST00000274341.4	-	3	1087	c.237T>C	c.(235-237)atT>atC	p.I79I	HAPLN1_ENST00000514416.1_Silent_p.I79I	NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	79	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		TGGTCCACTTAATTCGGATTT	0.428000													32	113					0	0	0.006230	0	0
MROH2B	133558	broad.mit.edu	37	5	41018861	41018861	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:41018861G>A	ENST00000399564.4	-	26	3055	c.2605C>T	c.(2605-2607)Cta>Tta	p.L869L	MROH2B_ENST00000506092.2_Silent_p.L424L	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		AGTTTTCCTAGGGCGTCCATG	0.453000													12	70					0	0	0.013537	0	0
CRB1	23418	broad.mit.edu	37	1	197326087	197326087	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:197326087C>T	ENST00000367400.3	+	5	1250	c.1115C>T	c.(1114-1116)tCt>tTt	p.S372F	CRB1_ENST00000538660.1_Missense_Mutation_p.S372F|CRB1_ENST00000543483.1_Missense_Mutation_p.S71F|CRB1_ENST00000535699.1_Missense_Mutation_p.S303F|CRB1_ENST00000367399.2_Missense_Mutation_p.S260F	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	372	EGF-like 9.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CTGCCTTCTTCTTTCAGCTAC	0.473000													14	71					0	0	0.004990	0	0
TRBV28	28559	broad.mit.edu	37	7	142428937	142428937	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:142428937C>T	ENST00000390400.2	+	0	317																											TTCTGGAGTCCGCCAGCACCA	0.478000													9	6					0	0	0.013537	0	0
SPOCK3	50859	broad.mit.edu	37	4	167656203	167656203	+	Missense_Mutation	SNP	C	C	T	rs141348000		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:167656203C>T	ENST00000357154.3	-	12	1317	c.1180G>A	c.(1180-1182)Gat>Aat	p.D394N	SPOCK3_ENST00000421836.2_Missense_Mutation_p.D343N|SPOCK3_ENST00000511531.1_Missense_Mutation_p.D394N|SPOCK3_ENST00000504953.1_Missense_Mutation_p.D391N|SPOCK3_ENST00000512681.1_Missense_Mutation_p.D296N|SPOCK3_ENST00000511269.1_Missense_Mutation_p.D391N|SPOCK3_ENST00000541354.1_Missense_Mutation_p.D274N|SPOCK3_ENST00000535728.1_Missense_Mutation_p.D262N|SPOCK3_ENST00000502330.1_Missense_Mutation_p.D394N|SPOCK3_ENST00000534949.1_Missense_Mutation_p.D298N|SPOCK3_ENST00000510741.1_Missense_Mutation_p.D351N|SPOCK3_ENST00000357545.4_Missense_Mutation_p.D391N|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000506886.1_Missense_Mutation_p.D394N|SPOCK3_ENST00000541637.1_Missense_Mutation_p.D296N	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	394	Asp-rich.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity	p.D391N(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		tcatgaaaatcgccactagca	0.343000													9	16					0	0	0.010729	0	0
EIF5A	1984	broad.mit.edu	37	17	7212975	7212975	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:7212975C>T	ENST00000336458.8	+	2	422	c.21C>T	c.(19-21)ttC>ttT	p.F7F	EIF5A_ENST00000336452.7_Silent_p.F37F|EIF5A_ENST00000416016.2_Silent_p.F7F|EIF5A_ENST00000573542.1_Silent_p.F7F|EIF5A_ENST00000572815.1_Silent_p.F7F|EIF5A_ENST00000571955.1_Silent_p.F7F|EIF5A_ENST00000576930.1_Silent_p.F7F|EIF5A_ENST00000419711.2_Silent_p.F7F	NM_001970.4	NP_001961.1	P63241	IF5A1_HUMAN	eukaryotic translation initiation factor 5A	7					induction of apoptosis|mRNA export from nucleus|peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein export from nucleus|translational frameshifting|transmembrane transport	annulate lamellae|cytosol|endoplasmic reticulum membrane|nuclear pore	protein N-terminus binding|ribosome binding|translation elongation factor activity|U6 snRNA binding			endometrium(2)|kidney(1)|large_intestine(2)|urinary_tract(1)	6						ACTTGGACTTCGAGACAGGAG	0.498000													35	90					0	0	0.017118	0	0
ATP13A4	84239	broad.mit.edu	37	3	193201733	193201733	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:193201733C>T	ENST00000342695.4	-	8	1122	c.800G>A	c.(799-801)gGg>gAg	p.G267E	ATP13A4_ENST00000295548.3_Missense_Mutation_p.G267E|ATP13A4_ENST00000392443.3_Missense_Mutation_p.G267E	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	267					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		ACCTTTTCTCCCACATACAGA	0.338000													28	84					0	0	0.008361	0	0
ADCY8	114	broad.mit.edu	37	8	131964190	131964190	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:131964190C>T	ENST00000286355.5	-	3	3257	c.1165G>A	c.(1165-1167)Gac>Aac	p.D389N	ADCY8_ENST00000377928.3_Missense_Mutation_p.D389N	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	389					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TTGGTCATGTCGTTGATCATT	0.532000										HNSCC(32;0.087)			31	55					0	0	0.008361	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058807	152058807	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:152058807C>T	ENST00000368806.1	-	3	1415	c.1351G>A	c.(1351-1353)Gga>Aga	p.G451R		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	451							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TGATCTCCTCCTTCTGAGCTT	0.443000													61	83					0	0	0.014410	0	0
FAIM2	23017	broad.mit.edu	37	12	50294991	50294991	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:50294991C>T	ENST00000320634.3	-	2	227	c.133G>A	c.(133-135)Gag>Aag	p.E45K	FAIM2_ENST00000550890.1_5'UTR	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	45					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane		p.E45Q(1)		endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						TTCATCCCCTCCCCAGAGGTG	0.662000													15	31					0	0	0.020292	0	0
UQCRFS1	7386	broad.mit.edu	37	19	29698939	29698939	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:29698939G>A	ENST00000304863.4	-	2	763	c.341C>T	c.(340-342)tCc>tTc	p.S114F		NM_006003.2	NP_005994.2	P47985	UCRI_HUMAN	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	114					respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)			TACCAAATAGGAGAAACCTTT	0.478000													10	48					0	0	0.013537	0	0
RERG	85004	broad.mit.edu	37	12	15262429	15262429	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:15262429C>T	ENST00000256953.2	-	5	551	c.215G>A	c.(214-216)gGg>gAg	p.G72E	RERG_ENST00000546331.1_Missense_Mutation_p.G53E|RERG_ENST00000536465.1_Missense_Mutation_p.G72E|RERG_ENST00000538313.1_Missense_Mutation_p.G72E	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	72					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						TCGCATGTGCCCCTCCCTCTG	0.458000													96	312					0	0	0.014410	0	0
CHD5	26038	broad.mit.edu	37	1	6206416	6206416	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:6206416G>A	ENST00000262450.3	-	11	1757	c.1658C>T	c.(1657-1659)cCc>cTc	p.P553L	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	553	Chromo 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GTAGTCAAAGGGGGGCGGCTC	0.557000													27	40					0	0	0.007291	0	0
CD2BP2	10421	broad.mit.edu	37	16	30364855	30364855	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:30364855G>A	ENST00000305596.3	-	5	817	c.642C>T	c.(640-642)aaC>aaT	p.N214N	CD2BP2_ENST00000569466.1_Silent_p.N214N	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	214					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						ACACACCAAGGTTGCCCCGGG	0.642000													17	45					0	0	0.010504	0	0
LAMA5	3911	broad.mit.edu	37	20	60901756	60901756	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr20:60901756G>A	ENST00000252999.3	-	40	5341	c.5275C>T	c.(5275-5277)Cgt>Tgt	p.R1759C		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1759	Laminin IV type A.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCTGCCCACGGTGAACGTGG	0.657000													11	34					0	0	0.016723	0	0
ABHD8	79575	broad.mit.edu	37	19	17412216	17412216	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:17412216C>T	ENST00000247706.3	-	2	449	c.210G>A	c.(208-210)ggG>ggA	p.G70G	MRPL34_ENST00000595444.1_Intron|MRPL34_ENST00000600434.1_Intron	NM_024527.4	NP_078803.4	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	70							hydrolase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)|urinary_tract(1)	9						CGGAGAGGTCCCCCTGGGCTG	0.697000													8	28					0	0	0.003080	0	0
BCL3	602	broad.mit.edu	37	19	45254573	45254573	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:45254573C>T	ENST00000164227.5	+	2	590	c.346C>T	c.(346-348)Ccc>Tcc	p.P116S		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	116	Pro-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CATGATGTGCCCCATGGAACA	0.592000			T	IGH@	CLL								240	635					0	0	0.014410	0	0
UGT2B10	7365	broad.mit.edu	37	4	69683807	69683807	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:69683807C>T	ENST00000265403.7	+	2	806	c.779C>T	c.(778-780)tCc>tTc	p.S260F	UGT2B10_ENST00000458688.2_Missense_Mutation_p.S176F	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	260					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						ATGCGAAACTCCTGGAATTTT	0.388000													10	24					0	0	0.006214	0	0
LRRC31	79782	broad.mit.edu	37	3	169579543	169579543	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:169579543G>A	ENST00000316428.5	-	2	291	c.234C>T	c.(232-234)ttC>ttT	p.F78F	LRRC31_ENST00000397805.2_5'UTR|LRRC31_ENST00000523069.1_Silent_p.F78F|LRRC31_ENST00000264676.5_Silent_p.F78F	NM_001277127.1|NM_024727.2	NP_001264056.1|NP_079003.2	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	78										cervix(3)|endometrium(3)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	31	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			GCTTCTGCAGGAAATGCTCAT	0.403000													40	73					0	0	0.006999	0	0
ADCY9	115	broad.mit.edu	37	16	4164632	4164632	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr16:4164632G>A	ENST00000294016.3	-	2	1350	c.812C>T	c.(811-813)tCg>tTg	p.S271L		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	271					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GGCTCCGGGCGAGGGGAAGCA	0.617000													5	24					0	0	0.001168	0	0
OAS3	4940	broad.mit.edu	37	12	113386755	113386755	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:113386755T>G	ENST00000228928.7	+	6	1298	c.1119T>G	c.(1117-1119)aaT>aaG	p.N373K	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	373	Linker.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						AGAGCCTCAATGCTGTGTACC	0.612000													10	20					0	0	0.008291	0	0
TMEM14E	645843	broad.mit.edu	37	3	152058520	152058520	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:152058520C>T	ENST00000408960.3	-	1	259	c.174G>A	c.(172-174)cgG>cgA	p.R58R	MBNL1_ENST00000324196.5_Intron|MBNL1_ENST00000355460.2_Intron|MBNL1_ENST00000493459.1_Intron|MBNL1_ENST00000545754.1_Intron|MBNL1_ENST00000282488.7_Intron|MBNL1_ENST00000357472.3_Intron|MBNL1_ENST00000282486.6_Intron|MBNL1_ENST00000463374.1_Intron|MBNL1_ENST00000492948.1_Intron|MBNL1_ENST00000485509.1_Intron|MBNL1_ENST00000485910.1_Intron|MBNL1_ENST00000324210.5_Intron|MBNL1_ENST00000498502.1_Intron	NM_001123228.1	NP_001116700.1	Q6UXP3	TM14E_HUMAN	transmembrane protein 14E	58						integral to membrane				lung(1)	1						CCTTTGGATTCCGTGATGGCT	0.458000													6	11					0	0	0.001168	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70591849	70591849	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:70591849C>T	ENST00000260126.3	-	8	2494	c.1788G>A	c.(1786-1788)cgG>cgA	p.R596R	SLCO5A1_ENST00000524945.1_Silent_p.R596R|SLCO5A1_ENST00000530307.1_Silent_p.R541R	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	596	Kazal-like.					integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CTGTATAATTCCGTATCTAAG	0.413000													37	130					0	0	0.007835	0	0
DUSP22	56940	broad.mit.edu	37	6	292544	292544	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:292544G>A	ENST00000419235.2	+	1	83	c.5G>A	c.(4-6)gGg>gAg	p.G2E	DUSP22_ENST00000605863.1_5'UTR|DUSP22_ENST00000605315.1_5'UTR|DUSP22_ENST00000603453.1_5'UTR|DUSP22_ENST00000605035.1_5'UTR|DUSP22_ENST00000344450.5_Missense_Mutation_p.G2E			Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	2					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(2)	26	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		GCCACCATGGGGAATGGGATG	0.687000													5	33					0	0	0.001984	0	0
TENM3	55714	broad.mit.edu	37	4	183549824	183549824	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:183549824G>A	ENST00000511685.1	+	5	893	c.770G>A	c.(769-771)gGa>gAa	p.G257E	TENM3_ENST00000406950.2_Missense_Mutation_p.G257E					teneurin transmembrane protein 3																		TTCAAAACAGGAACAGGTACA	0.428000													5	8					0	0	0.014758	0	0
ZNF99	7652	broad.mit.edu	37	19	22939443	22939443	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:22939443G>A	ENST00000397104.3	-	7	2727	c.2728C>T	c.(2728-2730)Cat>Tat	p.H910Y						zinc finger protein 99									p.H910Y(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCCCCAGTATGAATTATCTTA	0.358000													18	27					0	0	0.007413	0	0
ZNF577	84765	broad.mit.edu	37	19	52376886	52376886	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:52376886G>A	ENST00000301399.5	-	7	722	c.357C>T	c.(355-357)ctC>ctT	p.L119L	ZNF577_ENST00000412216.1_Intron|ZNF577_ENST00000451628.2_Intron|ZNF577_ENST00000420592.1_Intron|ZNF577_ENST00000485702.1_Intron	NM_032679.2	NP_116068.2	Q9BSK1	ZN577_HUMAN	zinc finger protein 577	119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GCTTGATATGGAGGCATGATC	0.368000													17	35					0	0	0.006122	0	0
STAT2	6773	broad.mit.edu	37	12	56745206	56745206	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:56745206G>A	ENST00000314128.4	-	9	834	c.811C>T	c.(811-813)Cac>Tac	p.H271Y	STAT2_ENST00000418572.2_Missense_Mutation_p.H267Y|STAT2_ENST00000557235.1_Missense_Mutation_p.H267Y			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	271					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						TGCCTCAGGTGAAACAACAGC	0.522000													42	121					0	0	0.011902	0	0
SPHK2	56848	broad.mit.edu	37	19	49131485	49131485	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:49131485C>T	ENST00000443164.1	+	4	1714	c.1009C>T	c.(1009-1011)Ccc>Tcc	p.P337S	SPHK2_ENST00000599029.1_Missense_Mutation_p.P239S|SPHK2_ENST00000599748.1_Missense_Mutation_p.P239S|SPHK2_ENST00000601712.1_Missense_Mutation_p.P239S|SPHK2_ENST00000598088.1_Missense_Mutation_p.P275S|SPHK2_ENST00000600537.1_Missense_Mutation_p.P216S|SPHK2_ENST00000245222.4_Missense_Mutation_p.P275S|SPHK2_ENST00000340932.3_Missense_Mutation_p.P239S			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	275					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GGGCATCCTCCCCTGCGGCTC	0.652000													13	26					0	0	0.003163	0	0
DSC1	1823	broad.mit.edu	37	18	28711631	28711631	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:28711631C>T	ENST00000257197.3	-	15	2674	c.2413G>A	c.(2413-2415)Gga>Aga	p.G805R	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Missense_Mutation_p.G805R|RP11-408H20.3_ENST00000582307.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	805					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TGCCCCACTCCCTTGACGGAC	0.507000													5	30					0	0	0.014758	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69424330	69424330	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chrX:69424330G>A	ENST00000333026.3	+	6	923	c.823G>A	c.(823-825)Ggc>Agc	p.G275S		NM_198512.1	NP_940914.1	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	275					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(1)	12						CGGATCCTGGGGCTTCCTGCC	0.473000													12	5					0	0	0.016723	0	0
OR2F2	135948	broad.mit.edu	37	7	143632533	143632533	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:143632533G>A	ENST00000408955.2	+	1	275	c.208G>A	c.(208-210)Gat>Aat	p.D70N		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					CTCCCTTGTCGATGTCTCCTA	0.502000													104	180					0	0	0.014410	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49658807	49658807	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:49658807G>A	ENST00000249601.4	-	9	1661	c.1365C>T	c.(1363-1365)tcC>tcT	p.S455S	ARHGAP22_ENST00000417912.2_Silent_p.S471S|ARHGAP22_ENST00000374170.1_Silent_p.S296S|ARHGAP22_ENST00000477708.2_Silent_p.S288S|ARHGAP22_ENST00000374172.1_Silent_p.S346S|ARHGAP22_ENST00000417247.2_Silent_p.S365S|ARHGAP22_ENST00000435790.2_Silent_p.S461S	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	455	Ser-rich.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCCCGCCGGAGGAGATGATGG	0.682000													3	4					0	0	0.004672	0	0
CEACAM8	1088	broad.mit.edu	37	19	43093018	43093018	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:43093018C>T	ENST00000244336.5	-	4	977	c.876G>A	c.(874-876)aaG>aaA	p.K292K	LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000594688.1_RNA|CEACAM8_ENST00000599005.1_Intron	NM_001816.3	NP_001807.2	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 8	292	Ig-like C2-type 2.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	16		Prostate(69;0.00899)				ATCCGCTGTTCTTTGTAGTGA	0.512000													31	65					0	0	0.007291	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45566602	45566602	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:45566602C>T	ENST00000588982.1	-	3	1378	c.877G>A	c.(877-879)Gag>Aag	p.E293K	ZBTB7C_ENST00000332053.2_Missense_Mutation_p.E293K|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.E293K|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.E293K|ZBTB7C_ENST00000586438.1_Missense_Mutation_p.E293K			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	293						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						TCCTCCTTCTCCTCCTCCTTG	0.617000													16	44					0	0	0.004007	0	0
FAM171A1	221061	broad.mit.edu	37	10	15296731	15296731	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:15296731C>T	ENST00000378116.4	-	4	572	c.566G>A	c.(565-567)gGa>gAa	p.G189E		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	189						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TGTTCCATTTCCGTCTAATCC	0.463000													14	37					0	0	0.020292	0	0
RHBDD1	84236	broad.mit.edu	37	2	227860179	227860179	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:227860179T>C	ENST00000392062.2	+	9	1413	c.889T>C	c.(889-891)Ttt>Ctt	p.F297L	RHBDD1_ENST00000493526.1_3'UTR|RHBDD1_ENST00000341329.3_Missense_Mutation_p.F297L	NM_001167608.1	NP_001161080.1	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	297						integral to membrane	serine-type endopeptidase activity			breast(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		ACCCTACGGGTTTCATCTCTC	0.458000													8	19					0	0	0.004482	0	0
KIF25	3834	broad.mit.edu	37	6	168440813	168440813	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:168440813C>T	ENST00000443060.2	+	7	954	c.563C>T	c.(562-564)cCc>cTc	p.P188L	KIF25_ENST00000351261.3_Missense_Mutation_p.P188L|KIF25_ENST00000354419.2_Missense_Mutation_p.P188L			Q9UIL4	KIF25_HUMAN	kinesin family member 25	188	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GCGAAGCACCCCACCCTGGTG	0.572000													17	34					0	0	0.004007	0	0
COL15A1	1306	broad.mit.edu	37	9	101806876	101806876	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:101806876C>T	ENST00000375001.3	+	25	3024	c.2601C>T	c.(2599-2601)atC>atT	p.I867I		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	867	Triple-helical region 4 (COL4).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding	p.I867I(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CGGGTGCCATCCTGACAGAGG	0.502000													14	61					0	0	0.003163	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634876	70634876	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:70634876G>A	ENST00000381269.2	-	2	1017	c.264C>T	c.(262-264)ttC>ttT	p.F88F	SLC8A3_ENST00000528359.1_Silent_p.F88F|SLC8A3_ENST00000534137.1_Silent_p.F88F|SLC8A3_ENST00000357887.3_Silent_p.F88F|SLC8A3_ENST00000356921.2_Silent_p.F88F	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	88					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ACACCCCAAGGAACATGTATA	0.493000													6	20					0	0	0.001168	0	0
GRB7	2886	broad.mit.edu	37	17	37901727	37901727	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:37901727G>A	ENST00000309156.4	+	11	1402	c.1145G>A	c.(1144-1146)gGg>gAg	p.G382E	GRB7_ENST00000445327.2_Missense_Mutation_p.G405E|GRB7_ENST00000394209.2_Missense_Mutation_p.G382E|GRB7_ENST00000394204.1_Missense_Mutation_p.G382E|GRB7_ENST00000309185.3_Missense_Mutation_p.G382E|GRB7_ENST00000394211.3_Missense_Mutation_p.G382E	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	382					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GGCCATGCTGGGCGTGTCATT	0.612000													16	59					0	0	0.004990	0	0
UBXN2A	165324	broad.mit.edu	37	2	24199943	24199943	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:24199943G>A	ENST00000309033.4	+	4	529	c.285G>A	c.(283-285)aaG>aaA	p.K95K	UBXN2A_ENST00000404924.1_Silent_p.K95K|UBXN2A_ENST00000535786.1_Silent_p.K95K|UBXN2A_ENST00000446425.2_3'UTR	NM_181713.3	NP_859064.2	P68543	UBX2A_HUMAN	UBX domain protein 2A	95	SEP.									endometrium(1)|large_intestine(3)|liver(1)|lung(6)	11						CCATCAAAAAGGGGTGAGTAg	0.473000													12	30					0	0	0.010729	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720207	140720207	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr5:140720207G>A	ENST00000394576.2	+	1	1669	c.1669G>A	c.(1669-1671)Gac>Aac	p.D557N	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACCAGAACGACAACGCGCC	0.617000													49	267					0	0	0.014410	0	0
IRF4	3662	broad.mit.edu	37	6	401488	401488	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:401488C>T	ENST00000380956.4	+	7	936	c.810C>T	c.(808-810)agC>agT	p.S270S		NM_001195286.1|NM_002460.3	NP_001182215.1|NP_002451.2	Q15306	IRF4_HUMAN	interferon regulatory factor 4	270					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		CCACGTCCAGCCCCGAGGGCT	0.602000			T	IGH@	MM								10	59					0	0	0.008291	0	0
FLG	2312	broad.mit.edu	37	1	152275372	152275372	+	Missense_Mutation	SNP	C	C	T	rs149094882		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:152275372C>T	ENST00000368799.1	-	3	12025	c.11990G>A	c.(11989-11991)gGa>gAa	p.G3997E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3997					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTAACACTTCCGTGCTGAGA	0.403000									Ichthyosis				27	89					0	0	0.006320	0	0
ENAM	10117	broad.mit.edu	37	4	71507955	71507955	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:71507955G>A	ENST00000396073.3	+	9	1093	c.812G>A	c.(811-813)gGa>gAa	p.G271E	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	271					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			AGCCCCACAGGAAACAGTACC	0.542000													15	25					0	0	0.020292	0	0
APOB	338	broad.mit.edu	37	2	21230763	21230763	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:21230763C>T	ENST00000233242.1	-	26	9104	c.8977G>A	c.(8977-8979)Gat>Aat	p.D2993N		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2993					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGCTGGGAATCGACTTGTGAT	0.418000													73	173					0	0	0.014410	0	0
ESPN	83715	broad.mit.edu	37	1	6505809	6505809	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:6505809G>A	ENST00000377828.1	+	7	1446	c.1278G>A	c.(1276-1278)ggG>ggA	p.G426G	RP1-202O8.2_ENST00000419034.1_RNA	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	426					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		GCACGATTGGGAAGcccacac	0.687000													8	12					0	0	0.003080	0	0
EVX2	344191	broad.mit.edu	37	2	176948373	176948373	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr2:176948373C>T	ENST00000308618.4	-	1	268	c.132G>A	c.(130-132)caG>caA	p.Q44Q		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	44						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GAGCCGGGTGCTGCGAATTTT	0.602000													14	60					0	0	0.016723	0	0
KCNMB3	27094	broad.mit.edu	37	3	178968596	178968596	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:178968596C>T	ENST00000392685.2	-	1	822	c.183G>A	c.(181-183)atG>atA	p.M61I	KCNMB3_ENST00000485523.1_Missense_Mutation_p.M43I|KCNMB3_ENST00000497599.1_Missense_Mutation_p.M63I|KCNMB3_ENST00000349697.2_Missense_Mutation_p.M63I|KCNMB3_ENST00000314235.5_Missense_Mutation_p.M65I	NM_171830.1	NP_741981.1	Q9NPA1	KCMB3_HUMAN	potassium large conductance calcium-activated channel, subfamily M beta member 3	65					detection of calcium ion|platelet activation|regulation of action potential in neuron	voltage-gated potassium channel complex	calcium-activated potassium channel activity|potassium channel regulator activity			NS(1)|large_intestine(1)|lung(2)|stomach(1)	5	all_cancers(143;5.6e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;2.41e-27)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.03)			AGAAGCCCATCATGGCAAACC	0.488000													33	78					0	0	0.013726	0	0
CHSY1	22856	broad.mit.edu	37	15	101718145	101718145	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:101718145G>A	ENST00000254190.3	-	3	2332	c.1857C>T	c.(1855-1857)tcC>tcT	p.S619S	CHSY1_ENST00000543813.1_5'UTR	NM_014918.4	NP_055733.2	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	619					chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(5)|skin(1)	24	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTTAAACTGGGAGGATCCTA	0.473000													11	37					0	0	0.008291	0	0
FMO3	2328	broad.mit.edu	37	1	171079999	171079999	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:171079999C>T	ENST00000367755.4	+	6	799	c.688C>T	c.(688-690)Cct>Tct	p.P230S	FMO3_ENST00000392085.2_Missense_Mutation_p.P230S|FMO3_ENST00000542847.1_Missense_Mutation_p.P210S|FMO3_ENST00000538429.1_Missense_Mutation_p.P167S	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	230					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAATGGTTATCCTTGGGACAT	0.463000													25	32					0	0	0.006320	0	0
TMEM190	147744	broad.mit.edu	37	19	55889382	55889382	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:55889382C>T	ENST00000291934.3	+	5	363	c.345C>T	c.(343-345)ttC>ttT	p.F115F	CTD-2105E13.15_ENST00000595064.1_RNA	NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	115						integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		TGCCCGGTTTCCTGGCGGGTC	0.706000													17	35					0	0	0.004990	0	0
PPP4R4	57718	broad.mit.edu	37	14	94674843	94674843	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:94674843C>T	ENST00000304338.3	+	3	388	c.234C>T	c.(232-234)ctC>ctT	p.L78L	PPP4R4_ENST00000555690.1_3'UTR|PPP4R4_ENST00000328839.3_Silent_p.L78L	NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	78						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TTGCAAATCTCCCATTTTTGA	0.373000													6	14					0	0	0.001984	0	0
RARA	5914	broad.mit.edu	37	17	38498981	38498981	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:38498981G>A	ENST00000394081.3	+	1	367	c.25G>A	c.(25-27)Ggt>Agt	p.G9S	RARA_ENST00000254066.5_Intron|CTD-2267D19.2_ENST00000581080.1_RNA|RARA_ENST00000394086.3_Intron|RARA_ENST00000394089.2_Intron|RARA_ENST00000425707.3_Intron	NM_001024809.3	NP_001019980.1	P10276	RARA_HUMAN	retinoic acid receptor, alpha	0	Modulating.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			breast(1)|kidney(4)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|urinary_tract(2)	16		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	AGAAGTGGGGGGTCCCACCCC	0.632000			T	"""PML, ZNF145, TIF1, NUMA1, NPM1"""	APL								63	71					0	0	0.014410	0	0
USHBP1	83878	broad.mit.edu	37	19	17373418	17373418	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:17373418G>A	ENST00000252597.3	-	4	758	c.585C>T	c.(583-585)gtC>gtT	p.V195V	USHBP1_ENST00000431146.2_Silent_p.V131V|USHBP1_ENST00000598570.1_5'UTR	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	195							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						CCTGCGTGCGGACCAGCTCAT	0.657000													41	25					0	0	0.014410	0	0
TPTE	7179	broad.mit.edu	37	21	10942968	10942968	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr21:10942968G>A	ENST00000298232.7	-	11	932	c.565C>T	c.(565-567)Cat>Tat	p.H189Y	TPTE_ENST00000361285.4_Missense_Mutation_p.H207Y|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.H169Y	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	207					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGAAACAGATGAAAAATTCTT	0.308000													8	45					0	0	0.003080	0	0
CASP1	834	broad.mit.edu	37	11	104900535	104900535	+	Missense_Mutation	SNP	C	C	T	rs45617533	byFrequency	TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:104900535C>T	ENST00000533400.1	-	6	754	c.719G>A	c.(718-720)cGg>cAg	p.R240Q	CASP1_ENST00000528974.1_Missense_Mutation_p.R201Q|CASP1_ENST00000393136.4_Missense_Mutation_p.R219Q|CASP1_ENST00000598974.1_Missense_Mutation_p.R240Q|CASP1_ENST00000525825.1_Missense_Mutation_p.R219Q|CASP1_ENST00000534497.1_Missense_Mutation_p.R147Q|CASP1_ENST00000593315.1_Missense_Mutation_p.R219Q|CASP1_ENST00000353247.5_Intron|CASP1_ENST00000415981.2_Intron|CASP1_ENST00000526568.1_Missense_Mutation_p.R147Q|CASP1_ENST00000594519.1_Missense_Mutation_p.R147Q|CASP1_ENST00000436863.3_Missense_Mutation_p.R240Q|CASP1_ENST00000446369.1_Missense_Mutation_p.R147Q|CASP1_ENST00000527979.1_Missense_Mutation_p.R203Q|CASP1_ENST00000531166.1_Intron	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	240					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	AATGCCTTCCCGAATACCATG	0.468000													12	32					0	0	0.013537	0	0
USP20	10868	broad.mit.edu	37	9	132641892	132641892	+	Silent	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:132641892C>T	ENST00000315480.4	+	24	2711	c.2553C>T	c.(2551-2553)gtC>gtT	p.V851V	USP20_ENST00000372429.3_Silent_p.V851V|USP20_ENST00000472108.1_3'UTR|USP20_ENST00000358355.1_Silent_p.V851V			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	851	DUSP 2.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				TTGCACAGGTCAAAGGAAGCG	0.657000													24	55					0	0	0.005443	0	0
TOP3B	8940	broad.mit.edu	37	22	22318385	22318385	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:22318385C>T	ENST00000398793.2	-	11	1548	c.1114G>A	c.(1114-1116)Gca>Aca	p.A372T	TOP3B_ENST00000357179.5_Missense_Mutation_p.A372T|TOP3B_ENST00000413067.2_Missense_Mutation_p.A101T	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	372					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		ATACCTTCTGCTAACAACCGC	0.612000													18	27					0	0	0.004990	0	0
PTPRC	5788	broad.mit.edu	37	1	198685862	198685862	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:198685862A>T	ENST00000367376.2	+	13	1508	c.1337A>T	c.(1336-1338)aAt>aTt	p.N446I	PTPRC_ENST00000348564.6_Missense_Mutation_p.N287I|PTPRC_ENST00000594404.1_Missense_Mutation_p.N285I|PTPRC_ENST00000352140.3_Missense_Mutation_p.N398I|PTPRC_ENST00000442510.2_Missense_Mutation_p.N448I	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	446	Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GATTTGCAAAATTTAAAACCT	0.303000													37	38					0	0	0.021022	0	0
DCC	1630	broad.mit.edu	37	18	50912500	50912500	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr18:50912500C>T	ENST00000442544.2	+	16	3063	c.2447C>T	c.(2446-2448)tCt>tTt	p.S816F	DCC_ENST00000412726.1_Missense_Mutation_p.S664F|DCC_ENST00000581580.1_Missense_Mutation_p.S471F	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	816					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ACCACCAGGTCTATAACCGGT	0.333000													10	30					0	0	0.008291	0	0
ATCAY	85300	broad.mit.edu	37	19	3905628	3905628	+	Silent	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr19:3905628G>A	ENST00000450849.2	+	4	800	c.333G>A	c.(331-333)ggG>ggA	p.G111G	ATCAY_ENST00000398448.3_Silent_p.G117G|ATCAY_ENST00000301260.6_Silent_p.G111G|ATCAY_ENST00000600960.1_Silent_p.G111G	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	111					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		AGTTCCTGGGGAATGGCAACG	0.582000													43	43					0	0	0.014410	0	0
TENM3	55714	broad.mit.edu	37	4	183651361	183651361	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr4:183651361C>T	ENST00000511685.1	+	15	2717	c.2594C>T	c.(2593-2595)tCt>tTt	p.S865F	TENM3_ENST00000406950.2_Missense_Mutation_p.S865F|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		AGCCTTGCATCTGTCATCAGA	0.378000													15	47					0	0	0.004990	0	0
PCDH15	65217	broad.mit.edu	37	10	55569283	55569283	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:55569283T>G	ENST00000395438.1	-	36	4971	c.4577A>C	c.(4576-4578)aAc>aCc	p.N1526T	PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395446.1_Missense_Mutation_p.K705N|PCDH15_ENST00000409834.1_Missense_Mutation_p.N1137T|PCDH15_ENST00000395442.1_Missense_Mutation_p.K374N|PCDH15_ENST00000395440.1_Missense_Mutation_p.K443N|PCDH15_ENST00000395445.1_Missense_Mutation_p.K1509N|PCDH15_ENST00000414778.1_Intron	NM_001142770.1	NP_001136242.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CAACCTTTGGTTTTTTAATTT	0.413000										HNSCC(58;0.16)			41	116					0	0	0.011902	0	0
RASGRP1	10125	broad.mit.edu	37	15	38803888	38803888	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr15:38803888T>A	ENST00000310803.5	-	8	1060	c.883A>T	c.(883-885)Atg>Ttg	p.M295L	RASGRP1_ENST00000558164.1_Missense_Mutation_p.M295L|RASGRP1_ENST00000450598.2_Missense_Mutation_p.M295L|RASGRP1_ENST00000561180.1_Missense_Mutation_p.M346L|RASGRP1_ENST00000539159.1_Missense_Mutation_p.M247L|RASGRP1_ENST00000559830.1_Missense_Mutation_p.M295L	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	295	Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		ATCACAGCCATCAGTGTATTG	0.473000													8	24					0	0	0.003080	0	0
ARHGAP8	23779	broad.mit.edu	37	22	45244881	45244881	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr22:45244881G>A	ENST00000517296.3	+	15	1448	c.1448G>A	c.(1447-1449)cGa>cAa	p.R483Q	ARHGAP8_ENST00000389774.2_Missense_Mutation_p.R304Q|ARHGAP8_ENST00000336963.4_Missense_Mutation_p.R273Q|ARHGAP8_ENST00000389773.5_Missense_Mutation_p.R395Q|PRR5-ARHGAP8_ENST00000352766.7_Missense_Mutation_p.R483Q|PRR5-ARHGAP8_ENST00000361473.5_Missense_Mutation_p.R404Q|ARHGAP8_ENST00000356099.6_Missense_Mutation_p.R273Q					Rho GTPase activating protein 8											breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(9)|prostate(1)|skin(7)	29		all_neural(38;0.00409)|Ovarian(80;0.00976)|Glioma(61;0.0649)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0204)		ACCTTCCTGCGAGAGCTGCCC	0.612000													38	120					0	0	0.013114	0	0
MYH2	4620	broad.mit.edu	37	17	10448786	10448786	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:10448786G>A	ENST00000245503.5	-	5	766	c.382C>T	c.(382-384)Ccc>Tcc	p.P128S	MYH2_ENST00000397183.2_Missense_Mutation_p.P128S|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Missense_Mutation_p.P128S	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	128	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CACTTGTAGGGGTTGACAGTG	0.468000													12	49					0	0	0.010729	0	0
MTR	4548	broad.mit.edu	37	1	237052538	237052538	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:237052538T>G	ENST00000366577.5	+	28	3303	c.2909T>G	c.(2908-2910)gTg>gGg	p.V970G	MTR_ENST00000535889.1_Missense_Mutation_p.V919G	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	970	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	CAGAAGCTGGTGGACTACATT	0.498000													6	97					0	0	0.003080	0	0
MYF5	4617	broad.mit.edu	37	12	81110842	81110842	+	Translation_Start_Site	SNP	G	G	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:81110842G>A	ENST00000228644.3	+	0	152					NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5						muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						CTCTCAGCAGGATGGACGTGA	0.637000													18	38					0	0	0.010504	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103573827	103573827	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:103573827A>T	ENST00000380069.3	+	8	1724	c.1648A>T	c.(1648-1650)Aag>Tag	p.K550*		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	550										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CCTCATGGACAAGGTGGTGAC	0.667000													9	38					0	0	0.008291	0	0
NEGR1	257194	broad.mit.edu	37	1	72058606	72058606	+	Silent	SNP	T	T	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:72058606T>G	ENST00000357731.4	-	6	1073	c.834A>C	c.(832-834)acA>acC	p.T278T	NEGR1_ENST00000306821.3_Silent_p.T150T|NEGR1_ENST00000434200.1_Silent_p.T232T	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	278	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GAATGGATCTTGTGCTAAAAT	0.413000													5	22					0	0	0.001168	0	0
TRBV29-1	28558	broad.mit.edu	37	7	142448676	142448676	+	RNA	SNP	C	C	T			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:142448676C>T	ENST00000422143.2	+	0	337																											ACCTAACATTCTCAACTCTGA	0.498000													5	8					0	0	0.001168	0	0
SSU72	29101	broad.mit.edu	37	1	1500119	1500120	+	Frame_Shift_Ins	INS	-	-	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr1:1500119_1500120insG	ENST00000359060.4	-	2	283_284	c.257_258insC	c.(256-258)ctgfs	p.L86fs	SSU72_ENST00000291386.3_Intron			Q9NP77	SSU72_HUMAN	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity			large_intestine(2)|lung(5)	7	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GAGGACCACACGGGGGGTTTTT	0.505													47	173	---	---	---	---					
PLXNB1	5364	broad.mit.edu	37	3	48461137	48461137	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:48461137delT	ENST00000358536.4	-	11	2827	c.2558delA	c.(2557-2559)gcfs	p.D853fs	PLXNB1_ENST00000456774.1_Intron|PLXNB1_ENST00000448774.2_Intron|PLXNB1_ENST00000296440.6_Frame_Shift_Del_p.D853fs|PLXNB1_ENST00000358459.4_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	853					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGTCCACTCGTCCGCCTCGGG	0.682													11	17	---	---	---	---					
CPN2	1370	broad.mit.edu	37	3	194062271	194062276	+	In_Frame_Del	DEL	CAGGTT	CAGGTT	-			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr3:194062271_194062276delCAGGTT	ENST00000323830.3	-	2	1245_1250	c.1156_1161delAACCTG	c.(1156-1161)del	p.NL386del	CPN2_ENST00000429275.1_In_Frame_Del_p.NL386del	NM_001080513.2	NP_001073982.2	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	386					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		CCAGGTTGAACAGGTTGTAGTTGGTG	0.597													13	60	---	---	---	---					
CNPY3	10695	broad.mit.edu	37	6	42897358	42897360	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:42897358_42897360delTGC	ENST00000372836.4	+	1	421_423	c.50_52delTGC	c.(49-54)ttg>t	p.LL23del	CNPY3_ENST00000394142.3_In_Frame_Del_p.LL23del	NM_006586.3	NP_006577.2	Q9BT09	CNPY3_HUMAN	canopy FGF signaling regulator 3	23					innate immune response	endoplasmic reticulum		p.L25delL(1)		central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)	6	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CTTCTTCCCTtgctgctgctgct	0.695													2	4	---	---	---	---					
RRP36	88745	broad.mit.edu	37	6	42989414	42989419	+	In_Frame_Del	DEL	GCCGGG	GCCGGG	-	rs60664426		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr6:42989414_42989419delGCCGGG	ENST00000244496.5	+	1	32_37	c.22_27delGCCGGG	c.(22-27)del	p.AG14del		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	14					ribosomal small subunit biogenesis|rRNA processing	nucleolus		p.A8_G9delAG(2)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						TAACTAccgcgccggggccggggccg	0.777													3	5	---	---	---	---					
CDK5	1020	broad.mit.edu	37	7	150754217	150754217	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr7:150754217delT	ENST00000485972.1	-	2	749	c.68delA	c.(67-69)acfs	p.N23fs	CDK5_ENST00000297518.4_Frame_Shift_Del_p.N23fs	NM_004935.3	NP_004926.1	Q00535	CDK5_HUMAN	cyclin-dependent kinase 5	23	Protein kinase.				activation of pro-apoptotic gene products|blood coagulation|cell division|cell proliferation|embryo development|negative regulation of transcription, DNA-dependent|positive regulation of neuron apoptosis	axon|cytosol|dendrite|growth cone|lamellipodium|membrane|neuromuscular junction|neuronal cell body	acetylcholine receptor activator activity|ATP binding|cyclin-dependent protein kinase activity|ErbB-2 class receptor binding|ErbB-3 class receptor binding|tau-protein kinase activity			central_nervous_system(1)|endometrium(2)|lung(5)|urinary_tract(1)	9		Breast(660;0.159)|Ovarian(593;0.182)	OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.008)|Lung(243;0.00942)|BRCA - Breast invasive adenocarcinoma(188;0.242)		AGTCTCCCGGTTTTTGGCCTT	0.582													7	355	---	---	---	---					
XKR5	389610	broad.mit.edu	37	8	6679301	6679302	+	RNA	DEL	CA	CA	-			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr8:6679301_6679302delCA	ENST00000518724.1	-	0	958							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		TGCATTGGTGcacacacacaca	0.401													3	4	---	---	---	---					
ZBTB34	403341	broad.mit.edu	37	9	129642541	129642541	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr9:129642541delC	ENST00000319119.4	+	2	948	c.863delC	c.(862-864)tcfs	p.S288fs	ZBTB34_ENST00000373452.2_Frame_Shift_Del_p.S284fs	NM_001099270.1	NP_001092740.1	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	284					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12						CACGCATACTCCTATTCCCAA	0.522													17	44	---	---	---	---					
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81443226	81443226	+	RNA	DEL	A	A	-	rs3832674		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr10:81443226delA	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							CTGTGGCAGCACTGGGGCAGC	0.537													5	9	---	---	---	---					
HNRNPKP3	399881	broad.mit.edu	37	11	43283606	43283606	+	RNA	DEL	A	A	-			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:43283606delA	ENST00000511537.1	-	0	1329					NR_033868.1																						AAGCAAATGTAAAAAAAAAAA	0.388													4	9	---	---	---	---					
SNX32	254122	broad.mit.edu	37	11	65617683	65617684	+	Frame_Shift_Ins	INS	-	-	A	rs143066310		TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr11:65617683_65617684insA	ENST00000308342.6	+	4	740_741	c.315_316insA	c.(313-318)ggagggfs	p.G106fs		NM_152760.2	NP_689973.2	Q86XE0	SNX32_HUMAN	sorting nexin 32	106	PX.				cell communication|protein transport		phosphatidylinositol binding			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				READ - Rectum adenocarcinoma(159;0.171)		AGAAATTGGGCGAGGGGGACAG	0.599													26	67	---	---	---	---					
AMIGO2	347902	broad.mit.edu	37	12	47471738	47471753	+	Frame_Shift_Del	DEL	TAACCAGACTTCCATT	TAACCAGACTTCCATT	-			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr12:47471738_47471753delTAACCAGACTTCCATT	ENST00000266581.4	-	2	1499_1514	c.1033_1048delAATGGAAGTCTGGTTA	c.(1033-1050)tafs	p.NGSLVI345fs	AMIGO2_ENST00000550413.1_Frame_Shift_Del_p.NGSLVI345fs|AMIGO2_ENST00000429635.1_Frame_Shift_Del_p.NGSLVI345fs|AMIGO2_ENST00000321382.3_Frame_Shift_Del_p.NGSLVI345fs	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	345	Ig-like C2-type.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					GGGCTTTCTATAACCAGACTTCCATTGTGAAACACG	0.421													14	86	---	---	---	---					
TEP1	7011	broad.mit.edu	37	14	20854287	20854287	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:20854287delA	ENST00000262715.5	-	20	2969	c.2929delT	c.(2929-2931)atfs	p.Y977fs	TEP1_ENST00000556935.1_Frame_Shift_Del_p.Y869fs	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	977					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		ATGTATCCATAACGGGAGCCC	0.552													38	114	---	---	---	---					
IGHV3-23	28442	broad.mit.edu	37	14	106725714	106725715	+	RNA	INS	-	-	G			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr14:106725714_106725715insG	ENST00000390609.2	-	0	18_19																											ATCCCAGGGCTGGGCTCCTCTC	0.500													9	83	---	---	---	---					
SUPT6H	6830	broad.mit.edu	37	17	27002005	27002006	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:27002005_27002006insA	ENST00000314616.6	+	5	646_647	c.363_364insA	c.(361-366)gtaaaafs	p.VK121fs	SUPT6H_ENST00000347486.4_Frame_Shift_Ins_p.VK121fs	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	121	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					ACCGGCGTGTCAAAAAAATGTC	0.485													43	55	---	---	---	---					
RP11-848P1.9	0	broad.mit.edu	37	17	29349140	29349141	+	RNA	INS	-	-	AT			TCGA-D9-A1JW-06A-11D-A19A-08	TCGA-D9-A1JW-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c8fb207-38ca-4eb4-b494-42fb039cd116	08bc1316-dd43-45f3-9aa2-4b4fd97e4d7f	g.chr17:29349140_29349141insAT	ENST00000579692.1	+	0	520_521																		p.?(1)									tgtgcatatacatatgtgtgtg	0.302													3	3	---	---	---	---					
