Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF215	7762	broad.mit.edu	37	11	6953513	6953513	+	Missense_Mutation	SNP	C	C	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:6953513C>A	ENST00000278319.5	+	3	598	c.10C>A	c.(10-12)Ctg>Atg	p.L4M	ZNF215_ENST00000527171.1_3'UTR|ZNF215_ENST00000529903.1_Missense_Mutation_p.L4M|ZNF215_ENST00000414517.2_Missense_Mutation_p.L4M	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	4					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		GATGCAGCCTCTGAGCAAGTT	0.453000													15	37					2.94398e-08	9.01037e-08	0.007413	1	0
GRB7	2886	broad.mit.edu	37	17	37898848	37898848	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:37898848C>T	ENST00000309156.4	+	3	442	c.185C>T	c.(184-186)aCc>aTc	p.T62I	GRB7_ENST00000445327.2_Missense_Mutation_p.T85I|GRB7_ENST00000578702.1_3'UTR|GRB7_ENST00000394204.1_Missense_Mutation_p.T62I|GRB7_ENST00000309185.3_Missense_Mutation_p.T62I|GRB7_ENST00000394209.2_Missense_Mutation_p.T62I|GRB7_ENST00000394211.3_Missense_Mutation_p.T62I	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	62					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			AGGCGTGCCACCTCCCTCCCC	0.612000													19	66					0	0	0.001882	0	0
B3GALNT2	148789	broad.mit.edu	37	1	235622058	235622058	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:235622058G>A	ENST00000366600.3	-	8	1106	c.878C>T	c.(877-879)cCt>cTt	p.P293L		NM_152490.2	NP_689703.1	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	293					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity	p.P293L(1)		NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			AAGTCTTTGAGGGCGAGAATG	0.383000													16	21					0	0	0.004007	0	0
DYNC1LI2	1783	broad.mit.edu	37	16	66770095	66770095	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:66770095G>A	ENST00000258198.2	-	5	788	c.582C>T	c.(580-582)tcC>tcT	p.S194S	DYNC1LI2_ENST00000379482.2_Intron|DYNC1LI2_ENST00000443351.2_Silent_p.S117S|DYNC1LI2_ENST00000440564.2_Silent_p.S155S	NM_006141.2	NP_006132.1	O43237	DC1L2_HUMAN	dynein, cytoplasmic 1, light intermediate chain 2	194					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(4)|stomach(1)	15		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		TTCTCTGTGGGGAACCTTGAC	0.453000													16	34					0	0	0.003163	0	0
GLIS1	148979	broad.mit.edu	37	1	53995556	53995556	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:53995556C>T	ENST00000312233.2	-	4	1431	c.865G>A	c.(865-867)Gag>Aag	p.E289K		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	289					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding	p.E289Q(1)|p.E289K(1)		endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						TACGGCTTCTCGCCCGTGTGG	0.637000													6	25					0	0	0.001984	0	0
CSPP1	79848	broad.mit.edu	37	8	68007696	68007696	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:68007696C>T	ENST00000262210.5	+	6	710	c.679C>T	c.(679-681)Cga>Tga	p.R227*	CSPP1_ENST00000412460.1_5'UTR	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	262						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			GGACAGATACCGACAACTAGA	0.368000													20	33					0	0	0.001523	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458668	20458668	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:20458668C>T	ENST00000426804.1	-	1	3118	c.2634G>A	c.(2632-2634)gaG>gaA	p.E878E		NM_015672.1	NP_056487.1			RIMS binding protein 3											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			CAAGCTCCCCCTCATAGAAGC	0.597000													4	11					0	0	0.000602	0	0
FYN	2534	broad.mit.edu	37	6	112017612	112017612	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:112017612C>T	ENST00000354650.3	-	10	1516	c.910G>A	c.(910-912)Ggc>Agc	p.G304S	FYN_ENST00000538466.1_Missense_Mutation_p.G301S|FYN_ENST00000368678.4_Missense_Mutation_p.G301S|FYN_ENST00000368667.2_Missense_Mutation_p.G304S|FYN_ENST00000368682.3_Missense_Mutation_p.G301S|FYN_ENST00000356013.2_Missense_Mutation_p.G249S|FYN_ENST00000476769.2_5'UTR|FYN_ENST00000229470.5_Missense_Mutation_p.G252S|FYN_ENST00000229471.4_Missense_Mutation_p.G249S	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	304	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	GACATTGTGCCTGGTTTAAGA	0.453000													12	13					0	0	0.002450	0	0
NIPAL1	152519	broad.mit.edu	37	4	48027085	48027085	+	Splice_Site	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:48027085G>A	ENST00000295461.5	+	2	113	c.46_splice	c.e2-1	p.G16_splice	NIPAL1_ENST00000508180.1_3'UTR	NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	16						integral to membrane				endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						TTTTTTCCAGGATATGTGCTG	0.488000													28	54					0	0	0.007291	0	0
HERC2P2	400322	broad.mit.edu	37	15	23283320	23283320	+	RNA	SNP	C	C	A	rs149049629	by1000genomes	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:23283320C>A	ENST00000560464.1	-	0	5097																											CAGCGTGTGCCTTTTCCTTCC	0.453000													6	27					2.0095e-06	6.11937e-06	0.001984	1	0
CHD7	55636	broad.mit.edu	37	8	61732609	61732609	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:61732609G>A	ENST00000423902.2	+	9	3136	c.2657G>A	c.(2656-2658)cGg>cAg	p.R886Q	CHD7_ENST00000525508.1_Missense_Mutation_p.R886Q|CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	886	Chromo 2.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GAGGTTGACCGGATAATGGAC	0.383000													4	12					0	0	0.001984	0	0
DEFB118	117285	broad.mit.edu	37	20	29960671	29960671	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:29960671G>A	ENST00000253381.2	+	2	103	c.70G>A	c.(70-72)Gaa>Aaa	p.E24K		NM_054112.2	NP_473453.1	Q96PH6	DB118_HUMAN	defensin, beta 118	24					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				breast(1)|endometrium(1)|lung(7)|ovary(3)|pancreas(1)|prostate(1)	14	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CTATAGTGGTGAAAAAAAATG	0.398000													10	7					0	0	0.006214	0	0
OR5J2	282775	broad.mit.edu	37	11	55944548	55944548	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:55944548G>A	ENST00000312298.1	+	1	455	c.455G>A	c.(454-456)gGa>gAa	p.G152E		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					TGGATAGGTGGAATAGTTAAC	0.453000													29	21					0	0	0.006320	0	0
TM4SF20	79853	broad.mit.edu	37	2	228228518	228228518	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:228228518C>T	ENST00000304568.3	-	4	649	c.612G>A	c.(610-612)ctG>ctA	p.L204L		NM_024795.3	NP_079071.2	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	204						integral to membrane|plasma membrane				breast(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(2)	10		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		TGAGCCCAAACAGGACCTCCA	0.403000													25	44					0	0	0.005443	0	0
DUXA	503835	broad.mit.edu	37	19	57666694	57666694	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:57666694C>T	ENST00000554048.2	-	5	484	c.485G>A	c.(484-486)aGg>aAg	p.R162K		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	162						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		CACAGGTTCCCTTTTTCTCTG	0.413000													7	42					0	0	0.001984	0	0
NEBL	10529	broad.mit.edu	37	10	21076194	21076194	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:21076194G>A	ENST00000377122.4	-	27	3201	c.2805C>T	c.(2803-2805)ggC>ggT	p.G935G	NEBL_ENST00000377159.4_Silent_p.G157G|NEBL_ENST00000417816.2_Silent_p.G191G	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	935	Linker.				regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TGTAGCCATAGCCTTGGGAAT	0.458000													10	18					0	0	0.000978	0	0
FTSJ2	29960	broad.mit.edu	37	7	2279183	2279183	+	Silent	SNP	G	G	A	rs145102163	by1000genomes	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:2279183G>A	ENST00000440306.2	-	2	203	c.168C>T	c.(166-168)agC>agT	p.S56S	FTSJ2_ENST00000486040.1_5'UTR|FTSJ2_ENST00000242257.8_Silent_p.S56S			Q9UI43	RRMJ2_HUMAN	FtsJ RNA methyltransferase homolog 2 (E. coli)	56					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		GCTTGAAGGCGCTTCGACACC	0.622000													23	34					0	0	0.003954	0	0
BMX	660	broad.mit.edu	37	X	15560224	15560224	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:15560224G>A	ENST00000357607.2	+	15	1702	c.1514G>A	c.(1513-1515)gGa>gAa	p.G505E	BMX_ENST00000348343.6_Missense_Mutation_p.G505E|BMX_ENST00000342014.6_Missense_Mutation_p.G505E			P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	505	Protein kinase.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(14)|ovary(2)|urinary_tract(3)	30	Hepatocellular(33;0.183)					AGGAGTCACGGAAAAGGACTT	0.438000													98	127					0	0	0.003610	0	0
MALAT1	378938	broad.mit.edu	37	11	65272211	65272211	+	RNA	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:65272211A>G	ENST00000534336.1	+	0	6979					NR_002819.2																						GGAAATGTTTAAACAGTTCAG	0.398000													11	34					0	0	0.001855	0	0
MUC16	94025	broad.mit.edu	37	19	9060576	9060576	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:9060576G>A	ENST00000397910.4	-	3	27073	c.26870C>T	c.(26869-26871)cCa>cTa	p.P8957L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8959	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGGAGGCCTGGATAAGAGGA	0.468000													71	65					0	0	0.003610	0	0
ZNF790	388536	broad.mit.edu	37	19	37314681	37314681	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:37314681G>A	ENST00000356725.4	-	3	141	c.21C>T	c.(19-21)ttC>ttT	p.F7F	CTD-2162K18.5_ENST00000588906.1_RNA|CTD-2162K18.5_ENST00000587278.1_RNA	NM_001242802.1|NM_206894.3	NP_001229731.1|NP_996777.2	Q6PG37	ZN790_HUMAN	zinc finger protein 790	7	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	32	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CCACATCCCTGAACATCATCA	0.393000													12	26					0	0	0.000978	0	0
NBEAL2	23218	broad.mit.edu	37	3	47038258	47038258	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:47038258C>T	ENST00000450053.3	+	17	2670	c.2491C>T	c.(2491-2493)Ccc>Tcc	p.P831S	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Missense_Mutation_p.P831S	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	831							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TGAGACGGCACCCTTCAAGCC	0.632000													5	14					0	0	0.003080	0	0
OR4K1	79544	broad.mit.edu	37	14	20404452	20404452	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:20404452C>T	ENST00000285600.4	+	1	686	c.627C>T	c.(625-627)agC>agT	p.S209S		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TATCATTGAGCTGTTTCCTGG	0.443000													15	52					0	0	0.004007	0	0
SEC14L1	6397	broad.mit.edu	37	17	75190974	75190974	+	Silent	SNP	C	C	T	rs138582657		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:75190974C>T	ENST00000413679.2	+	7	993	c.690C>T	c.(688-690)ccC>ccT	p.P230P	SEC14L1_ENST00000443798.4_Silent_p.P230P|SEC14L1_ENST00000430767.4_Silent_p.P230P|SEC14L1_ENST00000436233.4_Silent_p.P230P|SEC14L1_ENST00000591437.1_Silent_p.P196P|SEC14L1_ENST00000585618.1_Silent_p.P230P|SEC14L1_ENST00000431431.2_Silent_p.P196P|SEC14L1_ENST00000392476.2_Silent_p.P230P	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	230					transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						CACCTGAGCCCGTGGTGGGCA	0.632000													39	50					0	0	0.004878	0	0
ZBTB6	10773	broad.mit.edu	37	9	125673909	125673909	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:125673909G>A	ENST00000373659.3	-	2	531	c.443C>T	c.(442-444)cCt>cTt	p.P148L		NM_006626.5	NP_006617.1	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	11						CTTAACATCAGGATCAGAAGA	0.338000													12	25					0	0	0.000978	0	0
NKG7	4818	broad.mit.edu	37	19	51875054	51875054	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:51875054G>A	ENST00000221978.5	-	4	654	c.475C>T	c.(475-477)Cgt>Tgt	p.R159C	NKG7_ENST00000595217.1_3'UTR|NKG7_ENST00000600427.1_Missense_Mutation_p.R79C	NM_005601.3	NP_005592.1	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	159						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TAGCCAGGACGGGGACCGCCA	0.582000													28	116					0	0	0.002445	0	0
TMCO5A	145942	broad.mit.edu	37	15	38234396	38234396	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:38234396A>G	ENST00000558158.1	+	9	663	c.509A>G	c.(508-510)tAc>tGc	p.Y170C	TMCO5A_ENST00000540944.1_Missense_Mutation_p.Y170C|TMCO5A_ENST00000559502.1_Missense_Mutation_p.Y170C|TMCO5A_ENST00000319669.4_Missense_Mutation_p.Y170C			Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	170						integral to membrane				central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	15						TTGAAGAAGTACCAGGAAACG	0.363000													28	101					0	0	0.001786	0	0
ZNF423	23090	broad.mit.edu	37	16	49669774	49669774	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:49669774C>T	ENST00000561648.1	-	4	3342	c.3289G>A	c.(3289-3291)Gcc>Acc	p.A1097T	ZNF423_ENST00000563137.2_Missense_Mutation_p.A1037T|ZNF423_ENST00000567169.1_Missense_Mutation_p.A980T|ZNF423_ENST00000562520.1_Missense_Mutation_p.A1037T|ZNF423_ENST00000562871.1_Missense_Mutation_p.A1037T|ZNF423_ENST00000262383.2_Missense_Mutation_p.A1097T|ZNF423_ENST00000535559.1_Missense_Mutation_p.A980T	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1097					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GCGCTGCGGGCCATGCAGCCG	0.687000													11	8					0	0	0.000978	0	0
KLF4	9314	broad.mit.edu	37	9	110249863	110249863	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:110249863G>A	ENST00000374672.4	-	3	1285	c.812C>T	c.(811-813)cCg>cTg	p.P271L		NM_004235.4	NP_004226.3	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	271	Pro-rich.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(5)|large_intestine(1)|lung(3)|pancreas(1)|prostate(2)	16						GCACGTGCGCGGCGGCCCGCC	0.701000													5	2					0	0	0.001168	0	0
HMG20A	10363	broad.mit.edu	37	15	77759465	77759465	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:77759465A>G	ENST00000381714.3	+	5	694	c.266A>G	c.(265-267)aAa>aGa	p.K89R	HMG20A_ENST00000336216.4_Missense_Mutation_p.K89R	NM_018200.2	NP_060670.1	Q9NP66	HM20A_HUMAN	high mobility group 20A	89					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						GGTTGGTCCAAAGGAAGAAAG	0.413000													4	32					0	0	0.000248	0	0
RP1	6101	broad.mit.edu	37	8	55539965	55539965	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:55539965G>A	ENST00000220676.1	+	4	3671	c.3523G>A	c.(3523-3525)Gaa>Aaa	p.E1175K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1175					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATCACAGAGGAAGCTGATGA	0.408000													18	20					0	0	0.006122	0	0
IL3RA	3563	broad.mit.edu	37	X	1460719	1460719	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:1460719G>A	ENST00000331035.4	+	2	410	c.61G>A	c.(61-63)Gaa>Aaa	p.E21K	IL3RA_ENST00000381469.2_Missense_Mutation_p.E21K	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	21						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GCAAACGAAGGAAGGTAAGAA	0.577000													65	77					0	0	0.003610	0	0
CNTN4	152330	broad.mit.edu	37	3	2924836	2924836	+	Missense_Mutation	SNP	G	G	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:2924836G>C	ENST00000397461.1	+	8	1044	c.660G>C	c.(658-660)atG>atC	p.M220I	CNTN4_ENST00000358480.3_Start_Codon_SNP_p.M1I|CNTN4_ENST00000427331.1_Missense_Mutation_p.M220I|CNTN4_ENST00000418658.1_Missense_Mutation_p.M220I	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	220					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CAGGAGTGATGGGTGAATATG	0.373000													17	11					0	0	0.006122	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262588	140262588	+	Silent	SNP	C	C	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140262588C>A	ENST00000289272.2	+	1	735	c.735C>A	c.(733-735)tcC>tcA	p.S245S	PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.S245S|PCDHA12_ENST00000398631.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTACCAATCCGTTTATAAAG	0.453000													6	38					0.00198382	0.00601097	0.001984	1	0
FBXL7	23194	broad.mit.edu	37	5	15936615	15936615	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:15936615C>T	ENST00000504595.1	+	4	1277	c.796C>T	c.(796-798)Ccc>Tcc	p.P266S	FBXL7_ENST00000510662.1_Missense_Mutation_p.P219S|FBXL7_ENST00000329673.7_Missense_Mutation_p.P254S	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	266					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						TAAACTGTCACCCTTGCATGG	0.572000													13	31					0	0	0.001368	0	0
RRM1	6240	broad.mit.edu	37	11	4153577	4153577	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:4153577C>T	ENST00000300738.5	+	16	2035	c.1831C>T	c.(1831-1833)Ctg>Ttg	p.L611L	RRM1_ENST00000423050.2_Silent_p.L514L|RRM1_ENST00000534285.1_Silent_p.L389L|RRM1_ENST00000537197.1_Silent_p.L273L	NM_001033.3	NP_001024.1	P23921	RIR1_HUMAN	ribonucleotide reductase M1	611					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)	14		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	TGCTCAGATCCTGGGGAATAA	0.438000													10	38					0	0	0.006214	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610246	47610246	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:47610246G>A	ENST00000371891.3	+	8	953	c.922G>A	c.(922-924)Gac>Aac	p.D308N	CYP4A22_ENST00000371890.3_Intron|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000485117.1_Intron|CYP4A22_ENST00000294337.3_Missense_Mutation_p.D308N	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	308						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CATCTTGTCAGACAAGGACCT	0.557000													35	72					0	0	0.002222	0	0
DAB2	1601	broad.mit.edu	37	5	39383123	39383123	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:39383123G>A	ENST00000320816.6	-	10	1405	c.938C>T	c.(937-939)tCt>tTt	p.S313F	DAB2_ENST00000509337.1_Missense_Mutation_p.S292F|DAB2_ENST00000545653.1_Missense_Mutation_p.S292F|DAB2_ENST00000339788.6_Intron	NM_001343.3	NP_001334.2	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	313					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			AGATTTGAGAGAATCAAACGA	0.463000													28	95					0	0	0.008361	0	0
IL31RA	133396	broad.mit.edu	37	5	55206402	55206402	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:55206402C>T	ENST00000396834.1	+	14	1983	c.1487C>T	c.(1486-1488)tCc>tTc	p.S496F	IL31RA_ENST00000447346.2_Missense_Mutation_p.S515F|IL31RA_ENST00000490985.1_Missense_Mutation_p.S373F|IL31RA_ENST00000354961.4_Missense_Mutation_p.S496F|IL31RA_ENST00000359040.5_Missense_Mutation_p.S515F	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	483	Fibronectin type-III 5.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				GGCCTGGAGTCCCTGAAACGA	0.468000													28	24					0	0	0.008361	0	0
MAP3K2	10746	broad.mit.edu	37	2	128083323	128083323	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:128083323G>A	ENST00000409947.1	-	9	940	c.658C>T	c.(658-660)Ctt>Ttt	p.L220F	MAP3K2_ENST00000344908.5_Missense_Mutation_p.L220F			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2	220					activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		GGACTATCAAGTGATGGACAA	0.408000													23	56					0	0	0.003330	0	0
CFAP221	200373	broad.mit.edu	37	2	120369228	120369228	+	Splice_Site	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:120369228G>A	ENST00000602047.1	+	14	1475		c.e14-1		PCDP1_ENST00000597189.1_Splice_Site|PCDP1_ENST00000413369.3_Splice_Site			Q4G0U5	PCDP1_HUMAN								cilium	calmodulin binding					Colorectal(110;0.196)					TAAAAACCCAGCTAGACAGAG	0.348000													9	28					0	0	0.008291	0	0
IFLTD1	160492	broad.mit.edu	37	12	25679043	25679043	+	Missense_Mutation	SNP	G	G	C	rs145152190	by1000genomes	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:25679043G>C	ENST00000539744.1	-	6	913	c.434C>G	c.(433-435)cCg>cGg	p.P145R	IFLTD1_ENST00000458174.2_Missense_Mutation_p.P263R|IFLTD1_ENST00000282881.6_Missense_Mutation_p.P242R|IFLTD1_ENST00000445693.1_Missense_Mutation_p.P179R|IFLTD1_ENST00000413632.2_Intron	NM_001256266.1	NP_001243195.1	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	242						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					TTGACCGTTCGGTTTGCACAG	0.328000													7	39					0	0	0.008291	0	0
LTA	4049	broad.mit.edu	37	6	31541257	31541257	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:31541257C>T	ENST00000454783.1	+	4	663	c.405C>T	c.(403-405)gtC>gtT	p.V135V	LTA_ENST00000418386.2_Silent_p.V135V	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	135					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	CCCATGAGGTCCAGCTCTTCT	0.592000													17	106					0	0	0.004990	0	0
GAB3	139716	broad.mit.edu	37	X	153944500	153944500	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:153944500C>T	ENST00000369575.3	-	2	208	c.177G>A	c.(175-177)gtG>gtA	p.V59V	GAB3_ENST00000424127.2_Silent_p.V59V|GAB3_ENST00000496390.1_5'UTR	NM_001081573.1|NM_080612.2	NP_001075042.1|NP_542179.1	Q8WWW8	GAB3_HUMAN	GRB2-associated binding protein 3	59	PH.									NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)	25	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGAGGTCTATCACCCGGATGG	0.552000													36	30					0	0	0.006230	0	0
CDH17	1015	broad.mit.edu	37	8	95164197	95164197	+	Missense_Mutation	SNP	T	T	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:95164197T>G	ENST00000027335.3	-	13	1819	c.1695A>C	c.(1693-1695)caA>caC	p.Q565H	CDH17_ENST00000441892.2_Missense_Mutation_p.Q351H|CDH17_ENST00000450165.2_Missense_Mutation_p.Q565H	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	565	Cadherin 5.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTTGGGAAAATTGAGGTGCTT	0.438000													4	33					0	0	0.000602	0	0
OR10A3	26496	broad.mit.edu	37	11	7961032	7961032	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:7961032G>A	ENST00000360759.3	-	1	109	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCAGGAGGATGAATTCAACCA	0.398000													5	29					0	0	0.001168	0	0
EVC2	132884	broad.mit.edu	37	4	5624458	5624458	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:5624458G>A	ENST00000310917.2	-	14	2798	c.2067C>T	c.(2065-2067)ccC>ccT	p.P689P	EVC2_ENST00000344938.1_Silent_p.P769P|EVC2_ENST00000344408.5_Silent_p.P769P	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	769						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						GGAAGAGCCAGGGCACCCCAC	0.652000													17	22					0	0	0.004990	0	0
ZNF621	285268	broad.mit.edu	37	3	40571737	40571737	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:40571737C>T	ENST00000339296.5	+	4	641	c.189C>T	c.(187-189)caC>caT	p.H63H	ZNF621_ENST00000490457.1_3'UTR|ZNF621_ENST00000431278.1_5'UTR|ZNF621_ENST00000310898.1_Silent_p.H63H|ZNF621_ENST00000403205.2_Silent_p.H63H	NM_198484.3	NP_940886.1	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		TGATCTCCCACCTGGAGAGAG	0.507000													15	48					0	0	0.007413	0	0
KLF4	9314	broad.mit.edu	37	9	110249864	110249864	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:110249864G>A	ENST00000374672.4	-	3	1284	c.811C>T	c.(811-813)Ccg>Tcg	p.P271S		NM_004235.4	NP_004226.3	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	271	Pro-rich.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(5)|large_intestine(1)|lung(3)|pancreas(1)|prostate(2)	16						CACGTGCGCGGCGGCCCGCCG	0.701000													5	2					0	0	0.000602	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262124	140262124	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140262124G>A	ENST00000289272.2	+	1	271	c.271G>A	c.(271-273)Gac>Aac	p.D91N	PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.D91N|PCDHA12_ENST00000398631.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1												p.D91N(1)		NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTCGGATCGACCGCGAGGA	0.592000													56	94					0	0	0.003610	0	0
COL4A5	1287	broad.mit.edu	37	X	107824250	107824250	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:107824250G>A	ENST00000328300.6	+	16	1173	c.929G>A	c.(928-930)gGa>gAa	p.G310E	COL4A5_ENST00000361603.2_Missense_Mutation_p.G310E	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	310	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GGCCAACCAGGAATTCCTGTA	0.388000									Alport syndrome with Diffuse Leiomyomatosis				23	41					0	0	0.003954	0	0
NOL11	25926	broad.mit.edu	37	17	65732798	65732798	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:65732798C>T	ENST00000253247.4	+	10	1186	c.1071C>T	c.(1069-1071)tcC>tcT	p.S357S	NOL11_ENST00000535137.1_Silent_p.S175S	NM_015462.3	NP_056277.2	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	357						nucleolus				haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	11	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATGTCGTGTCCCATTTTGTAA	0.358000													4	22					0	0	0.000602	0	0
CYP1B1	1545	broad.mit.edu	37	2	38301675	38301675	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:38301675C>T	ENST00000260630.3	-	2	1258	c.857G>A	c.(856-858)gGg>gAg	p.G286E	CYP1B1_ENST00000494864.1_Intron|CYP1B1_ENST00000407341.1_Missense_Mutation_p.G286E	NM_000104.3	NP_000095.2	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B, polypeptide 1	286					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	13		all_hematologic(82;0.21)			Estrone(DB00655)	gggggcggccccgggccgAAG	0.627000													3	11					0	0	0.000248	0	0
SCN10A	6336	broad.mit.edu	37	3	38763770	38763770	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:38763770G>A	ENST00000449082.2	-	19	3485	c.3486C>T	c.(3484-3486)atC>atT	p.I1162I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1162					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGCTGAGCAGGATCATGAAGA	0.537000													19	29					0	0	0.007413	0	0
ZNF888	388559	broad.mit.edu	37	19	53418497	53418497	+	RNA	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:53418497G>A	ENST00000596623.1	-	0	502									zinc finger protein 888																		TCTCTGTATAGAGTCCTCTGA	0.463000													21	55					0	0	0.005443	0	0
MYOM1	8736	broad.mit.edu	37	18	3116406	3116406	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:3116406C>T	ENST00000400569.3	-	21	3559	c.3226G>A	c.(3226-3228)Gac>Aac	p.D1076N	MYOM1_ENST00000356443.4_Missense_Mutation_p.D1076N|MYOM1_ENST00000261606.7_Missense_Mutation_p.D980N			P52179	MYOM1_HUMAN	myomesin 1	1076	Fibronectin type-III 5.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TCCTTCAAGTCCACGAAGTAA	0.537000													10	20					0	0	0.008291	0	0
FLT3	2322	broad.mit.edu	37	13	28588639	28588639	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:28588639G>A	ENST00000380982.4	-	23	2899	c.2818C>T	c.(2818-2820)Cct>Tct	p.P940S	FLT3_ENST00000469894.1_5'UTR|FLT3_ENST00000537084.1_Missense_Mutation_p.P896S|FLT3_ENST00000241453.7_Missense_Mutation_p.P937S			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	937	Protein kinase.			T -> H (in Ref. 6; AAA35487).	positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	GTCAAATTAGGGAAGGATGGC	0.398000			"""Mis, O"""		"""AML, ALL"""								13	29					0	0	0.004990	0	0
ATP8A1	10396	broad.mit.edu	37	4	42580365	42580365	+	Missense_Mutation	SNP	A	A	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:42580365A>T	ENST00000381668.5	-	12	1271	c.1040T>A	c.(1039-1041)tTc>tAc	p.F347Y	ATP8A1_ENST00000264449.10_Missense_Mutation_p.F347Y	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	347					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	AAGGATGATGAAGGTCAAGAA	0.358000													24	35					0	0	0.001786	0	0
LILRA1	11024	broad.mit.edu	37	19	55106777	55106777	+	Missense_Mutation	SNP	C	C	T	rs141328341		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:55106777C>T	ENST00000453777.1	+	5	741	c.571C>T	c.(571-573)Cgc>Tgc	p.R191C	LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000251372.3_Missense_Mutation_p.R191C	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	191	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GAGCCCGAGTCGCAGGTGGTC	0.567000													29	80					0	0	0.005443	0	0
ZEB1	6935	broad.mit.edu	37	10	31810698	31810698	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:31810698C>T	ENST00000446923.2	+	7	2778	c.2387C>T	c.(2386-2388)cCc>cTc	p.P796L	ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000560721.2_Missense_Mutation_p.P792L|ZEB1_ENST00000320985.10_Missense_Mutation_p.P812L|ZEB1_ENST00000361642.5_Missense_Mutation_p.P813L|ZEB1_ENST00000542815.3_Missense_Mutation_p.P745L	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	812					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				GCCCAGTTACCCACAATCGTG	0.473000													14	31					0	0	0.003163	0	0
KDM3B	51780	broad.mit.edu	37	5	137761262	137761262	+	Missense_Mutation	SNP	A	A	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:137761262A>T	ENST00000314358.5	+	17	4602	c.4402A>T	c.(4402-4404)Atc>Ttc	p.I1468F	KDM3B_ENST00000542866.1_Missense_Mutation_p.I500F|KDM3B_ENST00000394866.1_Missense_Mutation_p.I1124F	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	1468					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						TGGTTTCGAGATCATATGCAG	0.408000													9	39					0	0	0.006214	0	0
MAP3K2	10746	broad.mit.edu	37	2	128083324	128083324	+	Silent	SNP	T	T	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:128083324T>A	ENST00000409947.1	-	9	939	c.657A>T	c.(655-657)tcA>tcT	p.S219S	MAP3K2_ENST00000344908.5_Silent_p.S219S			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2	219					activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		GACTATCAAGTGATGGACAAC	0.403000													22	57					0	0	0.002780	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655878	46655878	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:46655878C>T	ENST00000253255.5	-	1	3341	c.3342G>A	c.(3340-3342)tgG>tgA	p.W1114*		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1114					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AACCCTCTCTCCATTCACTCT	0.488000													16	43					0	0	0.006122	0	0
MTMR14	64419	broad.mit.edu	37	3	9743588	9743588	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:9743588C>T	ENST00000296003.4	+	19	2006	c.1884C>T	c.(1882-1884)gcC>gcT	p.A628A	MTMR14_ENST00000420925.1_Silent_p.A270A|MTMR14_ENST00000353332.5_Silent_p.A576A|MTMR14_ENST00000351233.5_Silent_p.A516A	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	628						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					CTTCCGGTGCCATCGGGGGCC	0.612000													21	59					0	0	0.004656	0	0
OR13C4	138804	broad.mit.edu	37	9	107288604	107288604	+	Missense_Mutation	SNP	T	T	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:107288604T>A	ENST00000277216.3	-	1	886	c.887A>T	c.(886-888)tAt>tTt	p.Y296F		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TCTCAAGCTATAGATTATGGG	0.398000													21	25					0	0	0.008871	0	0
APOB	338	broad.mit.edu	37	2	21260931	21260931	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:21260931C>T	ENST00000233242.1	-	5	563	c.436G>A	c.(436-438)Gag>Aag	p.E146K	APOB_ENST00000399256.4_Missense_Mutation_p.E146K	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	146	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCATCTTTCTCCGGGTAAAGG	0.493000													133	175					0	0	0.003610	0	0
ADAM7	8756	broad.mit.edu	37	8	24323234	24323234	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:24323234C>T	ENST00000175238.6	+	5	418	c.335C>T	c.(334-336)tCc>tTc	p.S112F	RP11-624C23.1_ENST00000519689.1_RNA|ADAM7_ENST00000380789.1_Missense_Mutation_p.S112F|RP11-624C23.1_ENST00000523578.1_RNA|ADAM7_ENST00000441335.2_Missense_Mutation_p.S112F	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	112					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TACCAAGGATCCATAGTACAC	0.289000													7	21					0	0	0.003080	0	0
CDH9	1007	broad.mit.edu	37	5	26916004	26916004	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:26916004C>T	ENST00000231021.4	-	3	429	c.257G>A	c.(256-258)gGa>gAa	p.G86E		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	86	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTTTAAATTTCCATCTCCTTT	0.338000													17	53					0	0	0.004990	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64137784	64137784	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:64137784C>T	ENST00000528057.1	+	15	1952	c.1864C>T	c.(1864-1866)Cgc>Tgc	p.R622C	RPS6KA4_ENST00000334205.4_Missense_Mutation_p.R629C|RPS6KA4_ENST00000294261.4_Missense_Mutation_p.R381C	NM_001006944.1	NP_001006945.1	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 4	629	Protein kinase 2.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			breast(1)|endometrium(3)|lung(7)|ovary(1)|prostate(1)	13						GTGCAAAATCCGCGAGGGGCG	0.657000													18	62					0	0	0.006122	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338908	13338908	+	RNA	SNP	T	T	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:13338908T>G	ENST00000602906.1	+	0	696																				kidney(3)|lung(1)	4						agaagaaaactaagaagatca	0.398000													4	13					0	0	0.000248	0	0
NCBP1	4686	broad.mit.edu	37	9	100431132	100431132	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:100431132G>A	ENST00000375147.3	+	21	2277	c.2021G>A	c.(2020-2022)aGt>aAt	p.S674N		NM_002486.4	NP_002477.1	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	674				S -> G (in Ref. 3; BAG35665).	gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)	19		Acute lymphoblastic leukemia(62;0.158)				CTATAGCGAAGTGATGATGAC	0.418000													6	19					0	0	0.001168	0	0
DNHD1	144132	broad.mit.edu	37	11	6541243	6541243	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:6541243C>T	ENST00000254579.6	+	9	2260	c.1696C>T	c.(1696-1698)Cat>Tat	p.H566Y	DNHD1_ENST00000354685.3_Missense_Mutation_p.H566Y|DNHD1_ENST00000527990.2_Missense_Mutation_p.H566Y	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	566					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CTTTGATGATCATGGTCAACT	0.463000													23	67					0	0	0.005443	0	0
BTNL8	79908	broad.mit.edu	37	5	180335686	180335686	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:180335686C>T	ENST00000231229.4	+	2	384	c.150C>T	c.(148-150)gcC>gcT	p.A50A	BTNL8_ENST00000400707.3_Intron|BTNL8_ENST00000340184.4_Silent_p.A50A|BTNL8_ENST00000511704.1_Intron|BTNL8_ENST00000508408.1_Silent_p.A50A	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	50	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATGCAGAGGCCATGGAAGTGC	0.577000													24	83					0	0	0.002780	0	0
CCDC102B	79839	broad.mit.edu	37	18	66564501	66564501	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:66564501G>A	ENST00000360242.5	+	6	1216	c.1099G>A	c.(1099-1101)Gaa>Aaa	p.E367K	CCDC102B_ENST00000584156.1_Missense_Mutation_p.E367K|CCDC102B_ENST00000319445.6_Missense_Mutation_p.E367K|CCDC102B_ENST00000577772.1_3'UTR|CCDC102B_ENST00000358653.5_Missense_Mutation_p.E367K	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	367										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				GGACAAGAGGGAAATACTTGA	0.403000													9	53					0	0	0.000978	0	0
PLD4	122618	broad.mit.edu	37	14	105394092	105394092	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:105394092C>T	ENST00000540372.1	+	3	386	c.194C>T	c.(193-195)cCc>cTc	p.P65L	PLD4_ENST00000392593.4_Missense_Mutation_p.P58L			Q96BZ4	PLD4_HUMAN	phospholipase D family, member 4	58					lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	13		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	CCCCGTCCTCCCACCTGGGGC	0.687000													5	2					0	0	0.001168	0	0
CLEC4C	170482	broad.mit.edu	37	12	7890135	7890135	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:7890135G>A	ENST00000542353.1	-	5	761	c.271C>T	c.(271-273)Cag>Tag	p.Q91*	CLEC4C_ENST00000354629.5_Nonsense_Mutation_p.Q60*|CLEC4C_ENST00000360345.3_Nonsense_Mutation_p.Q91*|CLEC4C_ENST00000540085.1_Nonsense_Mutation_p.Q60*	NM_130441.2	NP_569708.1	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C	91	C-type lectin.				innate immune response	integral to membrane	sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				Kidney(36;0.0915)		CAACTAGACTGAAATGAAGTC	0.403000													32	38					0	0	0.004289	0	0
KRTAP17-1	83902	broad.mit.edu	37	17	39471786	39471786	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:39471786C>T	ENST00000334202.3	-	1	161	c.117G>A	c.(115-117)ggG>ggA	p.G39G		NM_031964.1	NP_114170.1	Q9BYP8	KR171_HUMAN	keratin associated protein 17-1	39						intermediate filament				haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			agccagagcccccacagccac	0.687000													3	8					0	0	0.004672	0	0
SPEN	23013	broad.mit.edu	37	1	16257957	16257957	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:16257957C>T	ENST00000375759.3	+	11	5426	c.5222C>T	c.(5221-5223)tCg>tTg	p.S1741L		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1741					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding	p.S1741L(1)		NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCCGGGGCCTCGTTTTCCCAG	0.562000													25	195					0	0	0.004656	0	0
SLC8B1	80024	broad.mit.edu	37	12	113759054	113759054	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:113759054C>T	ENST00000552014.1	-	4	771	c.256G>A	c.(256-258)Ggc>Agc	p.G86S	SLC24A6_ENST00000546737.1_Missense_Mutation_p.G86S|SLC24A6_ENST00000202831.3_Missense_Mutation_p.G86S|SLC24A6_ENST00000553238.1_5'UTR			Q6J4K2	NCKX6_HUMAN		86					response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						CAGAAGATGCCTTCCAGGTAG	0.627000													16	59					0	0	0.004007	0	0
ARSF	416	broad.mit.edu	37	X	3030306	3030306	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:3030306C>T	ENST00000381127.1	+	11	1703	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	ARSF_ENST00000359361.2_Silent_p.F494F|ARSF_ENST00000537104.1_Silent_p.F494F	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	494						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCAGATGTTTCGGAGAACAGG	0.572000													41	108					0	0	0.003610	0	0
DENND2A	27147	broad.mit.edu	37	7	140301597	140301597	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:140301597G>A	ENST00000275884.6	-	2	1018	c.601C>T	c.(601-603)Ctt>Ttt	p.L201F	DENND2A_ENST00000492720.1_Missense_Mutation_p.L201F|DENND2A_ENST00000537639.1_Missense_Mutation_p.L201F|DENND2A_ENST00000496613.1_Missense_Mutation_p.L201F			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	201										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					TTCTCAGGAAGGGTGGACCCT	0.637000													8	57					0	0	0.004482	0	0
MIR525	574470	broad.mit.edu	37	19	54200822	54200822	+	RNA	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:54200822C>T	ENST00000384978.1	+	0	36					NR_030192.1																						TGCACTTTCTCTTATGTGAAA	0.433000													14	21					0	0	0.001855	0	0
OR9A2	135924	broad.mit.edu	37	7	142723902	142723902	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:142723902C>T	ENST00000350513.2	-	1	380	c.318G>A	c.(316-318)atG>atA	p.M106I		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					ATGCAAACTCCATGGTCCCAC	0.458000													16	18					0	0	0.003163	0	0
KNSTRN	90417	broad.mit.edu	37	15	40675118	40675118	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:40675118C>T	ENST00000416151.2	+	1	197	c.82C>T	c.(82-84)Ccg>Tcg	p.P28S	KNSTRN_ENST00000448395.2_Missense_Mutation_p.P28S|KNSTRN_ENST00000249776.8_Missense_Mutation_p.P28S	NM_001142761.1	NP_001136233.1			kinetochore-localized astrin/SPAG5 binding protein																		CCACCCACTTCCGCCTAGCTA	0.562000													19	24					0	0	0.007413	0	0
IL17D	53342	broad.mit.edu	37	13	21296055	21296055	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:21296055C>T	ENST00000304920.3	+	3	679	c.571C>T	c.(571-573)Ctc>Ttc	p.L191F		NM_138284.1	NP_612141.1	Q8TAD2	IL17D_HUMAN	interleukin 17D	191					inflammatory response	extracellular space	cytokine activity			endometrium(1)|skin(1)	2		all_cancers(29;9.63e-24)|all_epithelial(30;1.09e-19)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000301)|Epithelial(112;0.000633)|OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Lung(94;0.0154)|LUSC - Lung squamous cell carcinoma(192;0.0414)		GGGCGCCAAGCTCCTGCTGGG	0.721000													13	19					0	0	0.001855	0	0
TFAM	7019	broad.mit.edu	37	10	60154712	60154712	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:60154712G>A	ENST00000487519.1	+	7	1145	c.619G>A	c.(619-621)Gac>Aac	p.D207N	TFAM_ENST00000373895.3_Missense_Mutation_p.D175N|TFAM_ENST00000373899.3_3'UTR	NM_003201.1	NP_003192.1	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial	207					DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						TGCTAAAGAGGACGAAACTCG	0.289000													7	6					0	0	0.003080	0	0
IFNA16	3449	broad.mit.edu	37	9	21217173	21217173	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:21217173C>T	ENST00000380216.1	-	1	137	c.132G>A	c.(130-132)atG>atA	p.M44I		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	44					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		AGATTCTTCCCATTTGTGCCA	0.507000													49	25					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179587548	179587548	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:179587548C>T	ENST00000589042.1	-	76	22302	c.22078G>A	c.(22078-22080)Gat>Aat	p.D7360N	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.D6116N|TTN_ENST00000591111.1_Missense_Mutation_p.D7043N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7043	Ig-like 55.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTTGGTATCTCCTTTGTAC	0.428000													13	11					0	0	0.003163	0	0
NELFB	25920	broad.mit.edu	37	9	140161467	140161467	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:140161467G>A	ENST00000343053.4	+	9	1504	c.1167G>A	c.(1165-1167)gtG>gtA	p.V389V		NM_015456.3	NP_056271.2			negative elongation factor complex member B																		CTTTCAATGTGGATCAGAAAC	0.557000													5	32					0	0	0.001168	0	0
OR14A16	284532	broad.mit.edu	37	1	247978878	247978878	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:247978878G>A	ENST00000357627.1	-	1	153	c.154C>T	c.(154-156)Cat>Tat	p.H52Y		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						GTGTGGAGATGATGGTCCAAA	0.393000													16	29					0	0	0.004990	0	0
GMPPA	29926	broad.mit.edu	37	2	220366282	220366282	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:220366282G>A	ENST00000358215.3	+	4	592	c.223G>A	c.(223-225)Gag>Aag	p.E75K	AC053503.11_ENST00000429882.1_RNA|GMPPA_ENST00000373908.1_Missense_Mutation_p.E75K|GMPPA_ENST00000373917.3_Missense_Mutation_p.E75K|GMPPA_ENST00000341142.3_Missense_Mutation_p.E75K|GMPPA_ENST00000313597.5_Missense_Mutation_p.E75K	NM_205847.2	NP_995319.1	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	75					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity	p.E75K(1)		breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		CGCCCAGCAGGAGTTTAACCT	0.547000													36	46					0	0	0.004878	0	0
CRB1	23418	broad.mit.edu	37	1	197407692	197407692	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:197407692C>T	ENST00000367397.1	+	6	2766	c.1908C>T	c.(1906-1908)ccC>ccT	p.P636P	CRB1_ENST00000535699.1_Silent_p.P1231P|RP11-75C23.1_ENST00000422250.1_RNA|CRB1_ENST00000367399.2_Silent_p.P1143P|CRB1_ENST00000367400.3_Silent_p.P1255P|CRB1_ENST00000544212.1_Silent_p.P736P|CRB1_ENST00000538660.1_Silent_p.P719P			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1255	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						GCAGATTACCCTCAACAGTCT	0.408000													14	57					0	0	0.003163	0	0
FLT1	2321	broad.mit.edu	37	13	29004199	29004199	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:29004199G>A	ENST00000282397.4	-	8	1345	c.1094C>T	c.(1093-1095)cCg>cTg	p.P365L	FLT1_ENST00000539099.1_Missense_Mutation_p.P365L|FLT1_ENST00000541932.1_Missense_Mutation_p.P365L	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	365	Ig-like C2-type 4.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TACAACTTCCGGCGAGGGAAA	0.453000													25	55					0	0	0.007291	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													3	49					0	0	0.000248	0	0
OR51E1	143503	broad.mit.edu	37	11	4674041	4674041	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:4674041C>T	ENST00000396952.5	+	2	935	c.285C>T	c.(283-285)atC>atT	p.I95I	OR51E1_ENST00000530215.1_Intron	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCACTACCATCCAGTTTGATG	0.473000													4	27					0	0	0.000602	0	0
MRGPRE	116534	broad.mit.edu	37	11	3249685	3249685	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:3249685C>T	ENST00000389832.5	-	2	651	c.345G>A	c.(343-345)gcG>gcA	p.A115A	AC109309.4_ENST00000418995.2_RNA|MRGPRE_ENST00000436689.2_Silent_p.A114A			Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	114						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		CGCTGACGGCCGCCAGGAGAC	0.687000													4	11					0	0	0.000602	0	0
ZNF337	26152	broad.mit.edu	37	20	25656980	25656980	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:25656980G>A	ENST00000376436.1	-	4	1483	c.944C>T	c.(943-945)tCa>tTa	p.S315L	RP4-694B14.5_ENST00000439498.1_RNA|RP4-694B14.5_ENST00000414393.1_RNA|ZNF337_ENST00000252979.5_Missense_Mutation_p.S315L|ZNF337_ENST00000538750.1_Missense_Mutation_p.S283L|RP4-694B14.5_ENST00000455791.1_RNA					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CTTCTCCCCTGAATGCGCCTT	0.473000													34	86					0	0	0.002836	0	0
MAS1L	116511	broad.mit.edu	37	6	29454838	29454838	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:29454838C>T	ENST00000377127.3	-	1	900	c.842G>A	c.(841-843)aGc>aAc	p.S281N		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	281						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						GGGTGCCACGCTCAGGGGTAG	0.498000													7	33					0	0	0.003080	0	0
ZNF572	137209	broad.mit.edu	37	8	125989827	125989827	+	Silent	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:125989827T>C	ENST00000319286.5	+	3	1471	c.1317T>C	c.(1315-1317)ccT>ccC	p.P439P		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	439					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GAGAGAAACCTTATAAATGTC	0.438000										HNSCC(60;0.17)			29	43					0	0	0.007291	0	0
SAMD9	54809	broad.mit.edu	37	7	92730924	92730924	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:92730924C>T	ENST00000379958.2	-	3	4756	c.4487G>A	c.(4486-4488)gGa>gAa	p.G1496E		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1496						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GTCAATTTTTCCTTTGTGAAC	0.378000													14	21					0	0	0.002450	0	0
CLSTN2	64084	broad.mit.edu	37	3	140167423	140167423	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:140167423C>T	ENST00000458420.3	+	6	1040	c.850C>T	c.(850-852)Cac>Tac	p.H284Y		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	284					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CCCCAGCATCCACCTGGAGAC	0.537000										HNSCC(16;0.037)			47	86					0	0	0.003610	0	0
HLA-DQA1	3117	broad.mit.edu	37	6	32609191	32609191	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:32609191G>A	ENST00000343139.5	+	2	289	c.187G>A	c.(187-189)Gag>Aag	p.E63K	HLA-DQA1_ENST00000374949.2_Missense_Mutation_p.E63K|HLA-DQA1_ENST00000395363.1_Missense_Mutation_p.E63K	NM_002122.3	NP_002113.2	P01909	DQA1_HUMAN	major histocompatibility complex, class II, DQ alpha 1	63	Alpha-1.		G -> E (in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; dbSNP:rs1142323).		antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6						CGTGGACCTGGAGAGGAAGGA	0.517000													10	51					0	0	0.006214	0	0
MUC2	4583	broad.mit.edu	37	11	1097738	1097738	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:1097738G>A	ENST00000441003.2	+	36	6858	c.6831G>A	c.(6829-6831)gaG>gaA	p.E2277E	MUC2_ENST00000361558.6_3'UTR	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4639						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCAGCGGGGAGATCGTCTCCA	0.642000													12	14					0	0	0.001368	0	0
NPSR1	387129	broad.mit.edu	37	7	34698136	34698136	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:34698136G>A	ENST00000360581.1	+	1	240	c.112G>A	c.(112-114)Gga>Aga	p.G38R	AC005493.1_ENST00000399077.1_Intron|NPSR1_ENST00000381542.1_Missense_Mutation_p.G38R|NPSR1_ENST00000531252.1_Missense_Mutation_p.G38R|NPSR1_ENST00000465305.1_Missense_Mutation_p.G38R|NPSR1_ENST00000381553.3_Missense_Mutation_p.G38R|NPSR1-AS1_ENST00000419766.1_RNA|NPSR1_ENST00000359791.1_Missense_Mutation_p.G38R|NPSR1_ENST00000381539.3_Missense_Mutation_p.G38R	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	38						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	AGTGGTGGAAGGAAAGGAATG	0.483000													27	39					0	0	0.004656	0	0
CDR1	1038	broad.mit.edu	37	X	139866498	139866498	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:139866498C>T	ENST00000370532.2	-	1	225	c.34G>A	c.(34-36)Gac>Aac	p.D12N		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	12	23 X 6 AA approximate repeats.									breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				AAAGGTACGTCTTCCAGAAAA	0.413000													67	146					0	0	0.003610	0	0
IPP	3652	broad.mit.edu	37	1	46180064	46180064	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:46180064A>G	ENST00000396478.3	-	8	1486	c.1384T>C	c.(1384-1386)Tct>Cct	p.S462P		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	462						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					CAACGCTTAGAAAGTGGATCA	0.423000													9	25					0	0	0.006214	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52924079	52924079	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:52924079A>G	ENST00000371544.3	-	20	3626	c.3364T>C	c.(3364-3366)Tat>Cat	p.Y1122H	ZCCHC11_ENST00000257177.4_Missense_Mutation_p.Y1122H	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	1122					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						ATATATGCATATGAAGATAAA	0.388000													25	42					0	0	0.005443	0	0
MYO9A	4649	broad.mit.edu	37	15	72208774	72208774	+	Silent	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:72208774A>G	ENST00000356056.5	-	19	3094	c.2622T>C	c.(2620-2622)atT>atC	p.I874I	MYO9A_ENST00000444904.1_Silent_p.I855I|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000424560.1_Silent_p.I874I|MYO9A_ENST00000566885.1_Silent_p.I494I|MYO9A_ENST00000564571.1_Silent_p.I874I	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	874					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GAGACTTGGTAATGCGATCTT	0.348000													11	32					0	0	0.008291	0	0
PAPPA	5069	broad.mit.edu	37	9	118974139	118974139	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:118974139G>A	ENST00000328252.3	+	4	2215	c.1846G>A	c.(1846-1848)Ggg>Agg	p.G616R	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	616					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TGGTGACCCAGGGCCAGGAAA	0.532000													33	126					0	0	0.002445	0	0
CDH9	1007	broad.mit.edu	37	5	26915843	26915843	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:26915843C>T	ENST00000231021.4	-	3	590	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	140	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GATTCCGGTTCCACCTGCCGC	0.393000													39	107					0	0	0.006999	0	0
ELL3	80237	broad.mit.edu	37	15	44068348	44068348	+	Splice_Site	SNP	T	T	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:44068348T>A	ENST00000319359.3	-	3	811	c.168_splice	c.e3-1	p.Y57_splice	RP11-296A16.1_ENST00000417761.2_3'UTR	NM_025165.2	NP_079441.1	Q9HB65	ELL3_HUMAN	elongation factor RNA polymerase II-like 3	57					positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				cervix(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)	13		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		GAGTCTCAGATACTGGGGGTG	0.607000													7	16					0	0	0.001984	0	0
WNT9A	7483	broad.mit.edu	37	1	228113089	228113089	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:228113089G>A	ENST00000272164.5	-	2	237	c.227C>T	c.(226-228)cCg>cTg	p.P76L	WNT9A_ENST00000497852.1_5'UTR	NM_003395.2	NP_003386.1	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family, member 9A	76					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Prostate(94;0.0405)				TGCCACGCCCGGGTCCCGGCG	0.701000													7	4					0	0	0.001984	0	0
FILIP1L	11259	broad.mit.edu	37	3	99569213	99569213	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:99569213T>C	ENST00000331335.5	-	5	1777	c.1307A>G	c.(1306-1308)aAa>aGa	p.K436R	FILIP1L_ENST00000383694.2_Missense_Mutation_p.K196R|FILIP1L_ENST00000476723.1_Intron|FILIP1L_ENST00000354552.3_Missense_Mutation_p.K436R|FILIP1L_ENST00000471562.1_Missense_Mutation_p.K196R|CMSS1_ENST00000496116.1_Intron|CMSS1_ENST00000421999.2_Intron|FILIP1L_ENST00000487087.1_Missense_Mutation_p.K12R	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	436						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						TTGTTTGCTTTTGTTGAAAGC	0.358000													33	45					0	0	0.003271	0	0
RAB39B	116442	broad.mit.edu	37	X	154490184	154490184	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:154490184G>A	ENST00000369454.3	-	2	846	c.546C>T	c.(544-546)atC>atT	p.I182I		NM_171998.2	NP_741995.1	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	182					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding			breast(1)|central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(12)	19	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AGCCCTCCTGGATTGTAATCT	0.463000													29	51					0	0	0.006320	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30952022	30952022	+	Missense_Mutation	SNP	G	G	A	rs148732637		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:30952022G>A	ENST00000402321.1	-	3	507	c.190C>T	c.(190-192)Cgg>Tgg	p.R64W	GAL3ST1_ENST00000406361.1_Missense_Mutation_p.R64W|GAL3ST1_ENST00000338911.5_Missense_Mutation_p.R64W|GAL3ST1_ENST00000406955.1_Missense_Mutation_p.R64W|GAL3ST1_ENST00000443111.2_Missense_Mutation_p.R64W|GAL3ST1_ENST00000401975.1_Missense_Mutation_p.R64W|GAL3ST1_ENST00000402369.1_Missense_Mutation_p.R64W			Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	64					protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21						CCGTTGGCCCGGATCACTGCC	0.677000													18	28					0	0	0.006320	0	0
DHDDS	79947	broad.mit.edu	37	1	26769252	26769252	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:26769252C>T	ENST00000360009.2	+	4	288	c.211C>T	c.(211-213)Cta>Tta	p.L71L	DHDDS_ENST00000525682.2_Silent_p.L71L|DHDDS_ENST00000531955.1_3'UTR|DHDDS_ENST00000374185.3_Silent_p.L71L|DHDDS_ENST00000526219.1_Silent_p.L71L|DHDDS_ENST00000427245.2_Silent_p.L71L|DHDDS_ENST00000236342.7_Silent_p.L71L	NM_024887.3|NM_205861.2	NP_079163.2|NP_995583.1	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase	71							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(5)|endometrium(2)|large_intestine(2)|lung(4)|stomach(1)|urinary_tract(1)	15		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		CCTGGGCATCCTAGAGGTGAC	0.512000													47	58					0	0	0.003610	0	0
TMEM211	255349	broad.mit.edu	37	22	25334156	25334156	+	Silent	SNP	C	C	T	rs138723870		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:25334156C>T	ENST00000407886.1	-	3	339	c.87G>A	c.(85-87)agG>agA	p.R29R	TMEM211_ENST00000423535.1_Silent_p.R100R|TMEM211_ENST00000382744.1_Silent_p.R29R			Q6ICI0	TM211_HUMAN	transmembrane protein 211	100						integral to membrane				endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						CACTGCTTCTCCTTGGGCACA	0.527000													22	46					0	0	0.003330	0	0
UGT3A1	133688	broad.mit.edu	37	5	35954476	35954476	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:35954476C>T	ENST00000274278.3	-	7	1757	c.1400G>A	c.(1399-1401)gGa>gAa	p.G467E		NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	467						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTGCGTCGCTCCCCCAGTCTG	0.607000													24	14					0	0	0.003330	0	0
KCTD3	51133	broad.mit.edu	37	1	215792594	215792594	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:215792594C>T	ENST00000259154.4	+	17	2141	c.1847C>T	c.(1846-1848)tCc>tTc	p.S616F	KCTD3_ENST00000495537.1_3'UTR	NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	616						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		CCAGCAACTTCCGTAGTTCAG	0.393000													23	67					0	0	0.003330	0	0
IP6K2	51447	broad.mit.edu	37	3	48726087	48726087	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:48726087G>A	ENST00000328631.5	-	6	1123	c.900C>T	c.(898-900)cgC>cgT	p.R300R		NM_001005909.2|NM_016291.3	NP_001005909.1|NP_057375.2	Q9UHH9	IP6K2_HUMAN	inositol hexakisphosphate kinase 2	300					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	15						GGAGTTCACGGCGCAGGTACC	0.562000													28	34					0	0	0.006320	0	0
NSMCE1	197370	broad.mit.edu	37	16	27238131	27238131	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:27238131G>A	ENST00000361439.4	-	6	609	c.510C>T	c.(508-510)ggC>ggT	p.G170G	NSMCE1_ENST00000565384.1_5'UTR	NM_145080.3	NP_659547.2	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog (S. cerevisiae)	170					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding			endometrium(2)|large_intestine(2)|lung(3)	7						GGATGGCCCGGCCGTGCAGGG	0.612000													34	50					0	0	0.006230	0	0
CCDC142	84865	broad.mit.edu	37	2	74709731	74709731	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:74709731G>A	ENST00000393965.3	-	1	630	c.234C>T	c.(232-234)ccC>ccT	p.P78P	CCDC142_ENST00000471713.1_Intron|CCDC142_ENST00000290418.4_Silent_p.P78P	NM_032779.3	NP_116168.3	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	78										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	16						CGCCACCTGCGGGCCCCCGCC	0.741000													11	5					0	0	0.003163	0	0
OLFML2B	25903	broad.mit.edu	37	1	161989927	161989927	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:161989927C>T	ENST00000294794.3	-	2	643	c.220G>A	c.(220-222)Gac>Aac	p.D74N	OLFML2B_ENST00000367940.2_Missense_Mutation_p.D74N	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	74										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			CACTGACAGTCCGAGCCCTCA	0.567000													15	40					0	0	0.003163	0	0
DHDDS	79947	broad.mit.edu	37	1	26769251	26769251	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:26769251C>T	ENST00000360009.2	+	4	287	c.210C>T	c.(208-210)atC>atT	p.I70I	DHDDS_ENST00000525682.2_Silent_p.I70I|DHDDS_ENST00000531955.1_3'UTR|DHDDS_ENST00000374185.3_Silent_p.I70I|DHDDS_ENST00000526219.1_Silent_p.I70I|DHDDS_ENST00000427245.2_Silent_p.I70I|DHDDS_ENST00000236342.7_Silent_p.I70I	NM_024887.3|NM_205861.2	NP_079163.2|NP_995583.1	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase	70							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(5)|endometrium(2)|large_intestine(2)|lung(4)|stomach(1)|urinary_tract(1)	15		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		ACCTGGGCATCCTAGAGGTGA	0.517000													47	57					0	0	0.003610	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572753	140572753	+	Silent	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140572753T>C	ENST00000239446.4	+	1	812	c.628T>C	c.(628-630)Tta>Cta	p.L210L		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		210	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGCTCAGCTTAACCCTCAC	0.507000													44	53					0	0	0.002222	0	0
SLC8A1	6546	broad.mit.edu	37	2	40366808	40366808	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:40366808C>T	ENST00000406785.1	-	7	2359	c.2170G>A	c.(2170-2172)Gat>Aat	p.D724N	SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1_ENST00000542756.1_Missense_Mutation_p.D755N|SLC8A1_ENST00000542024.1_Missense_Mutation_p.D724N|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1_ENST00000408028.2_Missense_Mutation_p.D752N|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1_ENST00000405901.3_Missense_Mutation_p.D755N|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1_ENST00000405269.1_Missense_Mutation_p.D724N|SLC8A1_ENST00000403092.1_Missense_Mutation_p.D760N|SLC8A1_ENST00000402441.1_Missense_Mutation_p.D724N|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1_ENST00000332839.4_Missense_Mutation_p.D760N|SLC8A1_ENST00000406391.2_Missense_Mutation_p.D724N|SLC8A1-AS1_ENST00000444629.1_RNA			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	760					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCGTCGTCATCATCTTCCCCT	0.502000													27	43					0	0	0.002445	0	0
NOD2	64127	broad.mit.edu	37	16	50744798	50744798	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:50744798C>T	ENST00000300589.2	+	4	1081	c.976C>T	c.(976-978)Ctc>Ttc	p.L326F	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	326	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding	p.L326I(1)		cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				CCAGGAATTTCTCTTTGTCTT	0.592000													10	22					0	0	0.001368	0	0
ZNF786	136051	broad.mit.edu	37	7	148769064	148769064	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:148769064G>A	ENST00000316286.9	-	3	814	c.542C>T	c.(541-543)cCc>cTc	p.P181L	ZNF786_ENST00000451334.3_Missense_Mutation_p.P230L|ZNF786_ENST00000491431.1_Missense_Mutation_p.P267L			Q8N393	ZN786_HUMAN	zinc finger protein 786	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(2)	26	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GTTCCGGAAGGGGCCCCTCCC	0.677000													7	11					0	0	0.003080	0	0
TRPC7	57113	broad.mit.edu	37	5	135692901	135692901	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:135692901C>T	ENST00000513104.1	-	2	457	c.175G>A	c.(175-177)Gtc>Atc	p.V59I	TRPC7_ENST00000355180.3_Missense_Mutation_p.V59I|TRPC7_ENST00000426057.2_Missense_Mutation_p.V59I	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	59					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATTTTCCGGACCACCGGGATG	0.597000													25	73					0	0	0.007291	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617367	111617367	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:111617367C>T	ENST00000374667.3	-	1	1872	c.844G>A	c.(844-846)Gag>Aag	p.E282K		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	282						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TCCGGGAGCTCGTAGTCCACG	0.632000													16	22					0	0	0.004007	0	0
CDH8	1006	broad.mit.edu	37	16	61687849	61687849	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:61687849G>A	ENST00000577390.1	-	12	3017	c.2063C>T	c.(2062-2064)cCa>cTa	p.P688L	CDH8_ENST00000299345.6_Missense_Mutation_p.P688L|CDH8_ENST00000577730.1_Missense_Mutation_p.P688L	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	688					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AATTCCATCTGGATTTTGTAA	0.423000													43	51					0	0	0.002522	0	0
C11orf30	56946	broad.mit.edu	37	11	76174919	76174919	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:76174919C>T	ENST00000529032.1	+	6	626	c.626C>T	c.(625-627)tCt>tTt	p.S209F	C11orf30_ENST00000533248.1_Missense_Mutation_p.S223F|C11orf30_ENST00000524767.1_Missense_Mutation_p.S224F|C11orf30_ENST00000334736.3_Missense_Mutation_p.S209F|C11orf30_ENST00000525038.1_Missense_Mutation_p.S224F|C11orf30_ENST00000343878.3_Missense_Mutation_p.S209F|C11orf30_ENST00000525919.1_Missense_Mutation_p.S210F|C11orf30_ENST00000524490.1_Missense_Mutation_p.S210F			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	209	Interaction with BRCA2.|Poly-Ser.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						CGAACAAACTCTTCCAGCTCC	0.443000													44	45					0	0	0.003610	0	0
OR4C6	219432	broad.mit.edu	37	11	55433349	55433349	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:55433349C>T	ENST00000314259.3	+	1	736	c.707C>T	c.(706-708)tCt>tTt	p.S236F		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						AAAGCCCTCTCTACCTGCAGC	0.493000													13	52					0	0	0.002450	0	0
LRRC7	57554	broad.mit.edu	37	1	70226011	70226011	+	Missense_Mutation	SNP	T	T	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:70226011T>A	ENST00000310961.5	+	4	557	c.139T>A	c.(139-141)Ttt>Att	p.F47I	LRRC7_ENST00000370958.1_Missense_Mutation_p.F80I|LRRC7_ENST00000035383.5_Missense_Mutation_p.F42I|LRRC7_ENST00000415775.2_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	42						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AAAGGAGGTCTTTAACTTCGA	0.418000													6	23					0	0	0.003080	0	0
FREM2	341640	broad.mit.edu	37	13	39263084	39263084	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:39263084C>T	ENST00000280481.7	+	1	1819	c.1603C>T	c.(1603-1605)Cgc>Tgc	p.R535C		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	535					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCTGGTGCTTCGCATGGTGGA	0.587000													5	15					0	0	0.000602	0	0
MUC3A	4584	broad.mit.edu	37	7	100552100	100552100	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:100552100C>T	ENST00000319509.7	+	1	851	c.851C>T	c.(850-852)cCt>cTt	p.P284L						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						ACAGGCTTTCCTAGTCTCTCT	0.453000													14	240					0	0	0.003330	0	0
TMEM67	91147	broad.mit.edu	37	8	94809558	94809558	+	Splice_Site	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:94809558G>A	ENST00000453321.3	+	20	2018		c.e20-1		TMEM67_ENST00000409623.3_Splice_Site	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67						cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			TTCCTGACCAGGTGAGGGTGG	0.353000													14	40					0	0	0.008871	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111697959	111697959	+	Translation_Start_Site	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:111697959G>A	ENST00000340433.2	+	1	233	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_001004308.2	NP_001004308.2	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	1							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27						GAGACATAATGGAGAAGTGCA	0.468000													29	61					0	0	0.004878	0	0
STIL	6491	broad.mit.edu	37	1	47717418	47717418	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:47717418G>A	ENST00000360380.3	-	18	3617	c.3254C>T	c.(3253-3255)tCg>tTg	p.S1085L	STIL_ENST00000396221.2_Missense_Mutation_p.S1068L|STIL_ENST00000371877.3_Missense_Mutation_p.S1086L|STIL_ENST00000337817.5_Missense_Mutation_p.S1085L|STIL_ENST00000243182.6_Missense_Mutation_p.S1085L			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	1085					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				ATTTTGGTTCGATCGAGTGAC	0.403000													44	84					0	0	0.003610	0	0
CDX4	1046	broad.mit.edu	37	X	72667312	72667312	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:72667312C>T	ENST00000373514.2	+	1	223	c.223C>T	c.(223-225)Ccc>Tcc	p.P75S		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	75						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					CTGGGGCTCACCCTACAGTCC	0.602000													21	28					0	0	0.001882	0	0
FLT3	2322	broad.mit.edu	37	13	28588640	28588640	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:28588640G>A	ENST00000380982.4	-	23	2898	c.2817C>T	c.(2815-2817)ttC>ttT	p.F939F	FLT3_ENST00000469894.1_5'UTR|FLT3_ENST00000537084.1_Silent_p.F895F|FLT3_ENST00000241453.7_Silent_p.F936F			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	936	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TCAAATTAGGGAAGGATGGCC	0.398000			"""Mis, O"""		"""AML, ALL"""								13	30					0	0	0.004990	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955459	18955459	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:18955459G>A	ENST00000302797.3	-	1	1097	c.873C>T	c.(871-873)ctC>ctT	p.L291L		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	291					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GAGCCCTCTGGAGAACCAGCT	0.542000													10	34					0	0	0.008291	0	0
C11orf16	56673	broad.mit.edu	37	11	8942870	8942870	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:8942870G>A	ENST00000326053.5	-	6	1503	c.1397C>T	c.(1396-1398)tCc>tTc	p.S466F	C11orf16_ENST00000525780.1_Intron	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	466								p.S466Y(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		AGTCTAACGGGAATTCTTGTT	0.522000													31	30					0	0	0.002836	0	0
CHRNA4	1137	broad.mit.edu	37	20	61987406	61987406	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:61987406G>A	ENST00000370263.4	-	4	525	c.304C>T	c.(304-306)Cca>Tca	p.P102S	CHRNA4_ENST00000463705.1_Intron	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	102					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TAGTCAGCTGGGTCCCAGCGC	0.642000													6	37					0	0	0.001168	0	0
BPIFB2	80341	broad.mit.edu	37	20	31600712	31600712	+	Splice_Site	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:31600712C>T	ENST00000170150.3	+	4	502	c.308_splice	c.e4+1	p.R103_splice		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	103						extracellular region	lipid binding										CAAGGTCTTTCGGTGAGCGGA	0.562000													15	90					0	0	0.003163	0	0
STX19	415117	broad.mit.edu	37	3	93733335	93733335	+	Missense_Mutation	SNP	T	T	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:93733335T>A	ENST00000315099.2	-	2	1035	c.779A>T	c.(778-780)tAt>tTt	p.Y260F	ARL13B_ENST00000303097.7_Intron|ARL13B_ENST00000539730.1_Intron|ARL13B_ENST00000486562.1_Intron|ARL13B_ENST00000394222.3_Intron|ARL13B_ENST00000471138.1_Intron|ARL13B_ENST00000535334.1_Intron	NM_001001850.2	NP_001001850.1	Q8N4C7	STX19_HUMAN	syntaxin 19	260	t-SNARE coiled-coil homology.				intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity			kidney(2)|large_intestine(2)|lung(4)|prostate(1)	9						ATTGTTAACATACTCTTTTGT	0.343000													5	20					0	0	0.000602	0	0
TMEM175	84286	broad.mit.edu	37	4	941538	941538	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:941538C>T	ENST00000264771.4	+	2	196	c.11C>T	c.(10-12)cCc>cTc	p.P4L	TMEM175_ENST00000515740.1_Intron|TMEM175_ENST00000508204.1_Intron	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	4						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ATGTCCCAGCCCCGGACCCCA	0.692000													9	22					0	0	0.001368	0	0
RYR3	6263	broad.mit.edu	37	15	33955132	33955132	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:33955132G>A	ENST00000389232.4	+	35	5471	c.5401G>A	c.(5401-5403)Gaa>Aaa	p.E1801K	RYR3_ENST00000415757.3_Missense_Mutation_p.E1801K	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1801	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCGATTACCCGAATCCGTCAA	0.512000													58	95					0	0	0.003610	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315364	30315364	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:30315364T>C	ENST00000375377.1	-	3	3814	c.3713A>G	c.(3712-3714)aAa>aGa	p.K1238R		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	1238										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						TTCAATCACTTTGGAAGGGCT	0.483000													23	30					0	0	0.001882	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42104844	42104844	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:42104844C>T	ENST00000457542.2	+	7	915	c.629C>T	c.(628-630)aCc>aTc	p.T210I	MAPKBP1_ENST00000514566.1_Missense_Mutation_p.T210I|MAPKBP1_ENST00000456763.2_Missense_Mutation_p.T210I|MAPKBP1_ENST00000260357.7_Missense_Mutation_p.T98I|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.T210I	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	210										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GACAGCAAGACCTCAAAGGTG	0.577000													13	26					0	0	0.002450	0	0
PEG3	5178	broad.mit.edu	37	19	57328195	57328195	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:57328195C>T	ENST00000326441.9	-	10	1978	c.1615G>A	c.(1615-1617)Gaa>Aaa	p.E539K	PEG3_ENST00000598410.1_Missense_Mutation_p.E415K|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.E539K|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.E413K	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	539					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCCTCACATTCCTGATTCTTA	0.443000													21	71					0	0	0.001523	0	0
MS4A2	2206	broad.mit.edu	37	11	59860950	59860950	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:59860950G>A	ENST00000278888.3	+	5	558	c.456G>A	c.(454-456)ctG>ctA	p.L152L		NM_000139.4	NP_000130.1	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member 2	152					cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			endometrium(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)	17		all_epithelial(135;0.245)			Omalizumab(DB00043)	TCATCAACCTGAAGAAGAGCT	0.438000													28	34					0	0	0.001786	0	0
ZFHX4	79776	broad.mit.edu	37	8	77776234	77776234	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:77776234C>T	ENST00000521891.2	+	11	10732	c.10284C>T	c.(10282-10284)ttC>ttT	p.F3428F	ZFHX4_ENST00000050961.6_Silent_p.F3379F|ZFHX4_ENST00000455469.2_Silent_p.F3383F|ZFHX4_ENST00000518282.1_Silent_p.F3402F	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3379						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.F3412F(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCTGTTATTTCGGTCAGCCTT	0.438000										HNSCC(33;0.089)			4	14					0	0	0.000248	0	0
ALPK3	57538	broad.mit.edu	37	15	85401094	85401094	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:85401094G>A	ENST00000258888.5	+	6	3898	c.3731G>A	c.(3730-3732)gGc>gAc	p.G1244D		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1244					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CGCCTCACCGGCCTCCTGGAC	0.682000													6	17					0	0	0.001984	0	0
MXRA8	54587	broad.mit.edu	37	1	1289861	1289861	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:1289861G>A	ENST00000309212.6	-	6	1008	c.978C>T	c.(976-978)gtC>gtT	p.V326V	MXRA8_ENST00000445648.2_Silent_p.V326V|MXRA8_ENST00000342753.4_Silent_p.V225V	NM_032348.2	NP_115724.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8	326						integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TGACATTGATGACGTTGTGGC	0.687000													18	34					0	0	0.001523	0	0
SCN3A	6328	broad.mit.edu	37	2	165986630	165986630	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:165986630C>T	ENST00000360093.3	-	17	3233	c.2742G>A	c.(2740-2742)aaG>aaA	p.K914K	SCN3A_ENST00000409101.3_Silent_p.K865K|SCN3A_ENST00000283254.7_Silent_p.K914K	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	914						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CATCATTGATCTTGCAGACAC	0.498000													35	61					0	0	0.003610	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147183076	147183076	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:147183076G>A	ENST00000361727.3	+	11	2236	c.1720G>A	c.(1720-1722)Gac>Aac	p.D574N		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	574	EGF-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCAAACATGGGACAGCTTCAA	0.433000										HNSCC(39;0.1)			17	71					0	0	0.007413	0	0
FLRT3	23767	broad.mit.edu	37	20	14307575	14307575	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:14307575G>A	ENST00000378053.3	-	2	834	c.578C>T	c.(577-579)cCa>cTa	p.P193L	FLRT3_ENST00000341420.4_Missense_Mutation_p.P193L|MACROD2_ENST00000217246.4_Intron|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	193					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TTGAAGAGATGGTGATGAAAT	0.418000													48	29					0	0	0.003214	0	0
ASIC1	41	broad.mit.edu	37	12	50471139	50471139	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:50471139G>A	ENST00000228468.4	+	4	1087	c.702G>A	c.(700-702)ggG>ggA	p.G234G	ASIC1_ENST00000552438.1_Silent_p.G268G|ASIC1_ENST00000447966.2_Silent_p.G234G	NM_020039.3	NP_064423.2	P78348	ACCN2_HUMAN	acid-sensing (proton-gated) ion channel 1	234					calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	CTGTGTGGGGGGAGACTGGTA	0.642000													7	8					0	0	0.001984	0	0
BCS1L	617	broad.mit.edu	37	2	219525825	219525825	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:219525825G>A	ENST00000431802.1	+	2	814	c.115G>A	c.(115-117)Ggc>Agc	p.G39S	BCS1L_ENST00000439945.1_Missense_Mutation_p.G39S|BCS1L_ENST00000359273.3_Missense_Mutation_p.G39S|BCS1L_ENST00000412366.1_Missense_Mutation_p.G39S|BCS1L_ENST00000392109.1_Missense_Mutation_p.G39S|BCS1L_ENST00000392110.2_Missense_Mutation_p.G39S|BCS1L_ENST00000392111.2_Missense_Mutation_p.G39S			Q9Y276	BCS1_HUMAN	BC1 (ubiquinol-cytochrome c reductase) synthesis-like	39					mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	8		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGTCCAACTGGGCCTGGTGGC	0.597000													27	39					0	0	0.004656	0	0
SEC23B	10483	broad.mit.edu	37	20	18506573	18506573	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:18506573G>A	ENST00000336714.3	+	7	1263	c.831G>A	c.(829-831)ctG>ctA	p.L277L	SEC23B_ENST00000377465.1_Silent_p.L277L|SEC23B_ENST00000262544.2_Silent_p.L277L|SEC23B_ENST00000377475.3_Silent_p.L277L	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	277					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						TTGGCTTGCTGGAGGTAATTT	0.433000													19	43					0	0	0.003954	0	0
KRT19	3880	broad.mit.edu	37	17	39680045	39680045	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:39680045C>T	ENST00000361566.3	-	6	1213	c.1153G>A	c.(1153-1155)Gag>Aag	p.E385K		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				TCCTGTCCCTCGAGCAGGCTG	0.577000													5	21					0	0	0.000602	0	0
OR4C11	219429	broad.mit.edu	37	11	55371330	55371330	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:55371330G>A	ENST00000302231.4	-	1	544	c.520C>T	c.(520-522)Cat>Tat	p.H174Y		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						CAGCAATAATGATCAATCAAA	0.438000													22	18					0	0	0.001882	0	0
GRIA3	2892	broad.mit.edu	37	X	122387391	122387391	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:122387391G>A	ENST00000264357.5	+	3	798	c.506G>A	c.(505-507)cGa>cAa	p.R169Q	GRIA3_ENST00000541091.1_Missense_Mutation_p.R153Q|GRIA3_ENST00000479118.1_3'UTR|GRIA3_ENST00000371251.1_Missense_Mutation_p.R169Q|GRIA3_ENST00000371256.5_Missense_Mutation_p.R169Q|GRIA3_ENST00000542149.1_Missense_Mutation_p.R169Q	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	169					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	GACACAGAACGAGGTAAGAAG	0.433000													12	35					0	0	0.004990	0	0
NSFL1C	55968	broad.mit.edu	37	20	1424412	1424412	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:1424412G>A	ENST00000216879.4	-	9	1962	c.1095C>T	c.(1093-1095)atC>atT	p.I365I	NSFL1C_ENST00000350991.4_Silent_p.I367I|NSFL1C_ENST00000476071.1_Silent_p.I367I|NSFL1C_ENST00000381658.4_Silent_p.I254I|NSFL1C_ENST00000461211.1_5'UTR|NSFL1C_ENST00000353088.2_Silent_p.I334I	NM_016143.4	NP_057227.2	Q9UNZ2	NSF1C_HUMAN	NSFL1 (p97) cofactor (p47)	365	UBX.					chromosome|Golgi stack|nucleus	lipid binding|protein binding			breast(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	16						ACCGCTGCACGATGACAGCAT	0.597000													12	19					0	0	0.001855	0	0
ARF4	378	broad.mit.edu	37	3	57569729	57569729	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:57569729T>C	ENST00000303436.6	-	3	421	c.154A>G	c.(154-156)Aat>Gat	p.N52D	ARF4_ENST00000496292.1_Missense_Mutation_p.N25D|ARF4_ENST00000493378.1_5'UTR|ARF4_ENST00000489843.1_Intron	NM_001660.3	NP_001651.1	P18085	ARF4_HUMAN	ADP-ribosylation factor 4	52					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus	GTP binding|GTPase activity			large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.0449)|Kidney(284;0.0561)		GTTTCCACATTAAAACCTACA	0.333000													17	44					0	0	0.006122	0	0
HGF	3082	broad.mit.edu	37	7	81381519	81381519	+	Missense_Mutation	SNP	C	C	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:81381519C>G	ENST00000222390.5	-	5	768	c.542G>C	c.(541-543)cGa>cCa	p.R181P	HGF_ENST00000444829.2_Missense_Mutation_p.R181P|HGF_ENST00000457544.2_Missense_Mutation_p.R176P|HGF_ENST00000423064.2_Missense_Mutation_p.R181P|HGF_ENST00000453411.1_Missense_Mutation_p.R176P	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	181	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TTCTTCCCCTCGAGGATTTCG	0.433000													16	20					0	0	0.004990	0	0
NCAN	1463	broad.mit.edu	37	19	19338385	19338385	+	Silent	SNP	C	C	T	rs149325641		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:19338385C>T	ENST00000252575.5	+	8	1999	c.1956C>T	c.(1954-1956)acC>acT	p.T652T	NCAN_ENST00000538881.1_Silent_p.T103T	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	652					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			CCATCTCCACCGAGGCCAATA	0.617000													17	50					0	0	0.004990	0	0
KCNQ5	56479	broad.mit.edu	37	6	73879492	73879492	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:73879492G>A	ENST00000342056.2	+	12	1947	c.1549G>A	c.(1549-1551)Gat>Aat	p.D517N	KCNQ5_ENST00000355194.4_Missense_Mutation_p.D498N|KCNQ5_ENST00000402622.2_Missense_Mutation_p.D508N|KCNQ5_ENST00000414165.2_Intron|KCNQ5_ENST00000403813.2_Missense_Mutation_p.D489N|KCNQ5_ENST00000370398.1_Missense_Mutation_p.D498N|KCNQ5_ENST00000355635.3_Missense_Mutation_p.D499N	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	498					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TGGCACTGATGATGTATATGA	0.423000													14	11					0	0	0.003163	0	0
OR6N1	128372	broad.mit.edu	37	1	158735715	158735715	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:158735715C>T	ENST00000335094.2	-	1	777	c.758G>A	c.(757-759)gGg>gAg	p.G253E		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					AAGGATGCTCCCATAGAAGAT	0.537000													22	80					0	0	0.003330	0	0
BRINP3	339479	broad.mit.edu	37	1	190068027	190068027	+	Nonsense_Mutation	SNP	G	G	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:190068027G>T	ENST00000367462.3	-	8	1653	c.1422C>A	c.(1420-1422)tgC>tgA	p.C474*	FAM5C_ENST00000534846.1_Nonsense_Mutation_p.C372*|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		474						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CTTCAGGCTTGCAGAGCCCCT	0.572000													24	150					8.24728e-16	2.54993e-15	0.004656	1	0
CDCA8	55143	broad.mit.edu	37	1	38168923	38168923	+	Splice_Site	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:38168923G>A	ENST00000373055.1	+	7	761		c.e7-1		CDCA8_ENST00000327331.2_Splice_Site	NM_001256875.1|NM_018101.3	NP_001243804.1|NP_060571.1	Q53HL2	BOREA_HUMAN	cell division cycle associated 8						cell division|chromosome organization|mitotic metaphase|mitotic prometaphase	chromosome passenger complex|chromosome, centromeric region|cytosol|nucleolus|spindle	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(1)|stomach(1)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTTACCTGTAGGTCAAGCCGT	0.552000													63	67					0	0	0.003610	0	0
FCRL5	83416	broad.mit.edu	37	1	157512838	157512838	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:157512838C>T	ENST00000361835.3	-	6	1091	c.934G>A	c.(934-936)Gaa>Aaa	p.E312K	FCRL5_ENST00000356953.4_Missense_Mutation_p.E312K|FCRL5_ENST00000368189.3_Missense_Mutation_p.E312K|FCRL5_ENST00000368190.3_Missense_Mutation_p.E312K|FCRL5_ENST00000368191.3_Missense_Mutation_p.E227K	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	312	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AGAGAATCTTCCTGGGTTTCA	0.512000													18	22					0	0	0.007413	0	0
TIPARP	25976	broad.mit.edu	37	3	156395701	156395701	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:156395701T>C	ENST00000461166.1	+	2	803	c.215T>C	c.(214-216)gTt>gCt	p.V72A	TIPARP_ENST00000295924.7_Missense_Mutation_p.V72A|TIPARP_ENST00000542783.1_Missense_Mutation_p.V72A|TIPARP_ENST00000486483.1_Missense_Mutation_p.V72A	NM_001184717.1	NP_001171646.1	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	72							NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CTTGATGGGGTTTTTAGATCT	0.398000													35	54					0	0	0.002836	0	0
CENPI	2491	broad.mit.edu	37	X	100381742	100381742	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:100381742C>T	ENST00000372927.1	+	8	1009	c.732C>T	c.(730-732)ttC>ttT	p.F244F	CENPI_ENST00000218507.5_Silent_p.F244F|CENPI_ENST00000423383.1_Silent_p.F244F|CENPI_ENST00000372926.1_Silent_p.F244F	NM_006733.2	NP_006724.2	Q92674	CENPI_HUMAN	centromere protein I	244					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(19)|prostate(1)|skin(2)	30						TGTATAAGTTCTTTGCTCCTG	0.353000													93	212					0	0	0.003610	0	0
CHAC2	494143	broad.mit.edu	37	2	53995093	53995093	+	Missense_Mutation	SNP	T	T	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:53995093T>A	ENST00000295304.4	+	1	165	c.70T>A	c.(70-72)Tac>Aac	p.Y24N	GPR75-ASB3_ENST00000394717.2_Intron|GPR75-ASB3_ENST00000482829.1_Intron|ASB3_ENST00000406625.2_Intron|GPR75-ASB3_ENST00000352846.3_Intron|ASB3_ENST00000498475.2_Intron|GPR75-ASB3_ENST00000406687.1_Intron|GPR75-ASB3_ENST00000263634.3_Intron	NM_001008708.2	NP_001008708.1	Q8WUX2	CHAC2_HUMAN	ChaC, cation transport regulator homolog 2 (E. coli)	24										endometrium(1)|large_intestine(2)|lung(4)|prostate(1)	8			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GCTGGTCGGATACATCACCAA	0.627000											OREG0014616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	33					0	0	0.001984	0	0
WIPI2	26100	broad.mit.edu	37	7	5256236	5256236	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:5256236A>G	ENST00000288828.4	+	5	656	c.424A>G	c.(424-426)Att>Gtt	p.I142V	WIPI2_ENST00000404704.3_Missense_Mutation_p.I142V|WIPI2_ENST00000484262.1_Missense_Mutation_p.I83V|WIPI2_ENST00000401525.3_Missense_Mutation_p.I124V|WIPI2_ENST00000382384.2_Missense_Mutation_p.I124V	NM_001033518.1|NM_001278299.1|NM_015610.3	NP_001028690.1|NP_001265228.1|NP_056425.1	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	142					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)	16		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		CATCCACAACATTCGGGACAT	0.517000													30	27					0	0	0.004289	0	0
CDH13	1012	broad.mit.edu	37	16	83711854	83711854	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:83711854C>T	ENST00000566620.1	+	10	1616	c.1326C>T	c.(1324-1326)atC>atT	p.I442I	CDH13_ENST00000268613.10_Silent_p.I489I|CDH13_ENST00000428848.3_Silent_p.I403I	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	442	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CCCTGCTGATCAAAGTGGAAA	0.552000													16	17					0	0	0.003163	0	0
VWF	7450	broad.mit.edu	37	12	6231893	6231893	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:6231893C>T	ENST00000572068.1	-	3	544	c.164G>A	c.(163-165)aGa>aAa	p.R55K	VWF_ENST00000545906.1_5'UTR|VWF_ENST00000261405.5_Intron			P04275	VWF_HUMAN	von Willebrand factor	0	VWFD 1.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	agactgacctctgattttggc	0.512000													8	7					0	0	0.003080	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540625	169540625	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:169540625C>T	ENST00000340806.6	+	1	916	c.916C>T	c.(916-918)Cgc>Tgc	p.R306C		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	306										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						GGTCAACTTGCGCTTCCTGGA	0.582000													7	9					0	0	0.003080	0	0
CXorf40B	541578	broad.mit.edu	37	X	149100870	149100870	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:149100870C>T	ENST00000370406.3	-	5	1197	c.369G>A	c.(367-369)gtG>gtA	p.V123V	CXorf40B_ENST00000355203.2_Silent_p.V123V|CXorf40B_ENST00000370404.1_Silent_p.V123V|CXorf40B_ENST00000462691.1_Silent_p.V123V			Q96DE9	CX04B_HUMAN	chromosome X open reading frame 40B	123										endometrium(1)|lung(4)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GGTTTGAAATCACAGTCAGGT	0.502000													37	103					0	0	0.002522	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69419696	69419696	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:69419696C>T	ENST00000333026.3	+	3	331	c.231C>T	c.(229-231)acC>acT	p.T77T		NM_198512.1	NP_940914.1	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	77					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(1)	12						GAAACTGGACCCTATGGAAGT	0.552000													4	21					0	0	0.000602	0	0
GPR123	84435	broad.mit.edu	37	10	134912195	134912195	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:134912195C>T	ENST00000607359.1	+	13	2343	c.2343C>T	c.(2341-2343)ttC>ttT	p.F781F	GPR123_ENST00000392607.3_Silent_p.F61F			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	61						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		ATTTCTGCTTCCACGCGGCCC	0.652000													26	8					0	0	0.003954	0	0
FYN	2534	broad.mit.edu	37	6	112017611	112017611	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:112017611C>T	ENST00000354650.3	-	10	1517	c.911G>A	c.(910-912)gGc>gAc	p.G304D	FYN_ENST00000538466.1_Missense_Mutation_p.G301D|FYN_ENST00000368678.4_Missense_Mutation_p.G301D|FYN_ENST00000368667.2_Missense_Mutation_p.G304D|FYN_ENST00000368682.3_Missense_Mutation_p.G301D|FYN_ENST00000356013.2_Missense_Mutation_p.G249D|FYN_ENST00000476769.2_5'UTR|FYN_ENST00000229470.5_Missense_Mutation_p.G252D|FYN_ENST00000229471.4_Missense_Mutation_p.G249D	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	304	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	GGACATTGTGCCTGGTTTAAG	0.458000													12	12					0	0	0.002450	0	0
NKAP	79576	broad.mit.edu	37	X	119070327	119070327	+	Silent	SNP	C	C	T	rs10577974		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:119070327C>T	ENST00000371410.3	-	4	772	c.606G>A	c.(604-606)tcG>tcA	p.S202S	NKAP_ENST00000477789.1_5'UTR	NM_024528.3	NP_078804.2	Q8N5F7	NKAP_HUMAN	NFKB activating protein	202	Lys-rich.|Necessary for interaction with CIR1.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						GTTTTCTTTTCGATGATTTTT	0.348000													27	45					0	0	0.007291	0	0
DNAH2	146754	broad.mit.edu	37	17	7708669	7708669	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:7708669C>T	ENST00000572933.1	+	61	10860	c.9400C>T	c.(9400-9402)Cga>Tga	p.R3134*	DNAH2_ENST00000389173.2_Nonsense_Mutation_p.R3134*			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3134	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TATGATTCTTCGAGGCAACGA	0.507000													8	33					0	0	0.004482	0	0
KIAA0513	9764	broad.mit.edu	37	16	85105471	85105471	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:85105471C>T	ENST00000566428.1	+	3	1043	c.412C>T	c.(412-414)Cga>Tga	p.R138*	KIAA0513_ENST00000538274.1_Nonsense_Mutation_p.R138*|KIAA0513_ENST00000258180.3_Nonsense_Mutation_p.R138*|KIAA0513_ENST00000567328.1_Nonsense_Mutation_p.R138*			O60268	K0513_HUMAN	KIAA0513	138						cytoplasm				breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(9)|pancreas(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.234)		GTGGTTTGCTCGATACGTGAG	0.453000													11	22					0	0	0.001368	0	0
TPM4	7171	broad.mit.edu	37	19	16178515	16178515	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:16178515G>A	ENST00000538887.1	+	1	168	c.81G>A	c.(79-81)gcG>gcA	p.A27A	TPM4_ENST00000344824.6_Silent_p.A27A			P67936	TPM4_HUMAN	tropomyosin 4	152					cellular component movement|muscle filament sliding|response to oxidative stress	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding|calcium ion binding|structural constituent of muscle	p.A27A(1)	TPM4/ALK(12)	breast(1)|large_intestine(3)	4						AGGCGGAGGCGGATAAGAAAG	0.642000			T	ALK	ALCL								7	29					0	0	0.003080	0	0
NT5C1B	93034	broad.mit.edu	37	2	18766242	18766242	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:18766242G>A	ENST00000304081.4	-	4	361	c.261C>T	c.(259-261)ctC>ctT	p.L87L	NT5C1B-RDH14_ENST00000532967.1_Silent_p.L147L|NT5C1B_ENST00000359846.2_Silent_p.L147L|NT5C1B_ENST00000460052.1_5'UTR|NT5C1B_ENST00000600945.1_Silent_p.L147L	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AGCTGCTGGGGAGCTGCAGCA	0.637000													4	17					0	0	0.000248	0	0
KIF1A	547	broad.mit.edu	37	2	241722494	241722494	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:241722494G>A	ENST00000498729.2	-	9	1077	c.831C>T	c.(829-831)acC>acT	p.T277T	KIF1A_ENST00000320389.7_Silent_p.T277T	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	277	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CCTTGCCCAGGGTGGTCAGCG	0.652000													12	44					0	0	0.001368	0	0
TRPM3	80036	broad.mit.edu	37	9	73164507	73164507	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:73164507C>T	ENST00000377110.2	-	24	3865	c.3622G>A	c.(3622-3624)Gat>Aat	p.D1208N	TRPM3_ENST00000377111.2_Missense_Mutation_p.D1208N|TRPM3_ENST00000396285.1_Missense_Mutation_p.D1067N|TRPM3_ENST00000360823.2_Missense_Mutation_p.D1070N|TRPM3_ENST00000377106.1_Missense_Mutation_p.D1080N|TRPM3_ENST00000423814.3_Missense_Mutation_p.D1235N|TRPM3_ENST00000377105.1_Missense_Mutation_p.D1067N|TRPM3_ENST00000408909.2_Missense_Mutation_p.D1067N|TRPM3_ENST00000396292.4_Missense_Mutation_p.D1080N|TRPM3_ENST00000396280.5_Missense_Mutation_p.D1057N|TRPM3_ENST00000357533.2_Missense_Mutation_p.D1212N|TRPM3_ENST00000358082.3_Missense_Mutation_p.D1070N	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	1233						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TTGAACCGATCATCCTTTTCT	0.423000													8	47					0	0	0.003080	0	0
TTN	7273	broad.mit.edu	37	2	179611474	179611474	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:179611474C>T	ENST00000360870.5	-	46	15875	c.15653G>A	c.(15652-15654)cGa>cAa	p.R5218Q	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000589042.1_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8737	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R5218Q(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATTTATTTCGATACCATTT	0.373000													14	25					0	0	0.001855	0	0
KCNK13	56659	broad.mit.edu	37	14	90651153	90651153	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:90651153G>A	ENST00000282146.4	+	2	1474	c.1033G>A	c.(1033-1035)Gag>Aag	p.E345K		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	345						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				GCTCTCAGGGGAGATGATCTC	0.617000													19	41					0	0	0.006122	0	0
SPESP1	246777	broad.mit.edu	37	15	69223008	69223008	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:69223008C>T	ENST00000310673.3	+	1	170	c.16C>T	c.(16-18)Ctt>Ttt	p.L6F	NOX5_ENST00000455873.3_5'UTR|NOX5_ENST00000448182.3_5'UTR|RP11-809H16.2_ENST00000557966.1_RNA|NOX5_ENST00000260364.5_5'UTR|SPESP1_ENST00000560188.1_Intron	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	6					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						GCCCTTAGTCCTTCTAGTTGC	0.617000													47	79					0	0	0.003610	0	0
SPESP1	246777	broad.mit.edu	37	15	69223007	69223007	+	Silent	SNP	C	C	T	rs150328243	byFrequency	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:69223007C>T	ENST00000310673.3	+	1	169	c.15C>T	c.(13-15)gtC>gtT	p.V5V	NOX5_ENST00000455873.3_5'UTR|NOX5_ENST00000448182.3_5'UTR|RP11-809H16.2_ENST00000557966.1_RNA|NOX5_ENST00000260364.5_5'UTR|SPESP1_ENST00000560188.1_Intron	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	5					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						AGCCCTTAGTCCTTCTAGTTG	0.622000													48	82					0	0	0.003610	0	0
ZNF683	257101	broad.mit.edu	37	1	26691377	26691377	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:26691377G>A	ENST00000436292.1	-	4	780	c.660C>T	c.(658-660)ctC>ctT	p.L220L	ZNF683_ENST00000403843.1_Silent_p.L220L|ZNF683_ENST00000374204.1_Silent_p.L220L|ZNF683_ENST00000349618.3_Silent_p.L220L			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GGGGCAGCATGAGGAGGTGGG	0.617000													27	33					0	0	0.007291	0	0
DRP2	1821	broad.mit.edu	37	X	100486727	100486727	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:100486727C>T	ENST00000395209.3	+	3	618	c.91C>T	c.(91-93)Ctc>Ttc	p.L31F	DRP2_ENST00000538510.1_Missense_Mutation_p.L31F|DRP2_ENST00000402866.1_Missense_Mutation_p.L31F|DRP2_ENST00000541709.1_Intron	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	31					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						TAGCAGCAGCCTCCGAAGCAC	0.537000													24	64					0	0	0.004656	0	0
C12orf60	144608	broad.mit.edu	37	12	14976118	14976118	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:14976118G>A	ENST00000330828.2	+	2	453	c.249G>A	c.(247-249)aaG>aaA	p.K83K	C12orf60_ENST00000527783.1_Intron	NM_175874.3	NP_787070.2	Q5U649	CL060_HUMAN	chromosome 12 open reading frame 60	83										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	9						AAATTCAAAAGGAGTCTTTAT	0.358000													17	49					0	0	0.004007	0	0
DUSP4	1846	broad.mit.edu	37	8	29194670	29194670	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:29194670C>T	ENST00000240100.2	-	4	1447	c.1058G>A	c.(1057-1059)cGg>cAg	p.R353Q	DUSP4_ENST00000240101.2_Missense_Mutation_p.R262Q	NM_001394.6	NP_001385.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	353	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		GGTCTTGCCCCGCTCCCGCAG	0.687000													5	8					0	0	0.001168	0	0
FGD5	152273	broad.mit.edu	37	3	14862703	14862703	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:14862703C>T	ENST00000285046.5	+	1	2235	c.2125C>T	c.(2125-2127)Cgg>Tgg	p.R709W	FGD5_ENST00000543601.1_Missense_Mutation_p.R468W	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	709					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						GCTTAAGTCTCGGACTGGGAA	0.557000													14	23					0	0	0.001855	0	0
GTF3C5	9328	broad.mit.edu	37	9	135927463	135927463	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:135927463C>T	ENST00000372097.5	+	5	1108	c.785C>T	c.(784-786)cCc>cTc	p.P262L	GTF3C5_ENST00000342018.8_Intron|GTF3C5_ENST00000372095.5_Missense_Mutation_p.P137L|GTF3C5_ENST00000372099.6_Missense_Mutation_p.P253L|GTF3C5_ENST00000372108.5_Missense_Mutation_p.P262L	NM_012087.3	NP_036219.2	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5, 63kDa	262						transcription factor TFIIIC complex	DNA binding|protein binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		GACATCCGTCCCATCTGGTCC	0.567000													15	20					0	0	0.003163	0	0
NELFB	25920	broad.mit.edu	37	9	140161468	140161468	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:140161468G>A	ENST00000343053.4	+	9	1505	c.1168G>A	c.(1168-1170)Gat>Aat	p.D390N		NM_015456.3	NP_056271.2			negative elongation factor complex member B																		TTTCAATGTGGATCAGAAACT	0.552000													5	32					0	0	0.001168	0	0
HIAT1	64645	broad.mit.edu	37	1	100546081	100546081	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:100546081C>T	ENST00000370152.3	+	11	1268	c.1132C>T	c.(1132-1134)Cga>Tga	p.R378*	RP4-714D9.2_ENST00000432294.1_RNA	NM_033055.2	NP_149044.2	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	378					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		AACAGGAATTCGAGGATTATG	0.388000													31	60					0	0	0.001786	0	0
CHRNA3	1136	broad.mit.edu	37	15	78893932	78893932	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:78893932G>A	ENST00000326828.5	-	5	1436	c.1052C>T	c.(1051-1053)cCc>cTc	p.P351L	CHRNA3_ENST00000348639.3_Missense_Mutation_p.P351L	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	351					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CATGACCCTGGGGAGCAGGTT	0.552000													29	37					0	0	0.008361	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64085191	64085191	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:64085191G>A	ENST00000295902.6	-	8	2656	c.2071C>T	c.(2071-2073)Cga>Tga	p.R691*	RP11-129B22.1_ENST00000482609.1_RNA|PRICKLE2-AS1_ENST00000476308.1_RNA|PRICKLE2_ENST00000564377.1_Nonsense_Mutation_p.R747*	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	691	Arg-rich.					cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CGAGAGCGTCGGGAACGCCTG	0.632000													16	39					0	0	0.001523	0	0
SGMS1	259230	broad.mit.edu	37	10	52103615	52103615	+	Missense_Mutation	SNP	A	A	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:52103615A>T	ENST00000361781.2	-	7	1219	c.260T>A	c.(259-261)aTt>aAt	p.I87N	SGMS1_ENST00000429490.1_Intron|SGMS1_ENST00000361543.2_Missense_Mutation_p.I87N	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	93					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						GTCTACGCCAATGTTGAGGTG	0.512000													21	26					0	0	0.002780	0	0
NRXN1	9378	broad.mit.edu	37	2	50758484	50758484	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:50758484G>A	ENST00000404971.1	-	12	3687	c.2348C>T	c.(2347-2349)tCc>tTc	p.S783F	NRXN1_ENST00000401669.2_Missense_Mutation_p.S743F|NRXN1_ENST00000406859.3_Missense_Mutation_p.S743F|NRXN1_ENST00000406316.2_Missense_Mutation_p.S743F|NRXN1_ENST00000405472.3_Missense_Mutation_p.S735F|NRXN1_ENST00000402717.3_Missense_Mutation_p.S735F|NRXN1_ENST00000331040.5_5'UTR	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	743	Laminin G-like 4.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GAACCGTAAGGAAACATCCTC	0.512000													4	15					0	0	0.000248	0	0
LRRC31	79782	broad.mit.edu	37	3	169557996	169557996	+	Missense_Mutation	SNP	C	C	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:169557996C>G	ENST00000316428.5	-	9	1490	c.1433G>C	c.(1432-1434)cGg>cCg	p.R478P	LRRC31_ENST00000264676.5_Missense_Mutation_p.R422P|LRRC31_ENST00000523069.1_3'UTR	NM_001277127.1|NM_024727.2	NP_001264056.1|NP_079003.2	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	478										cervix(3)|endometrium(3)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	31	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			TTTGAGGAACCGCACGTTTTG	0.473000													23	37					0	0	0.003954	0	0
KCNQ5	56479	broad.mit.edu	37	6	73787061	73787061	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:73787061C>T	ENST00000342056.2	+	4	1031	c.633C>T	c.(631-633)atC>atT	p.I211I	KCNQ5_ENST00000355194.4_Silent_p.I211I|KCNQ5_ENST00000402622.2_Silent_p.I211I|KCNQ5_ENST00000414165.2_Silent_p.I211I|KCNQ5_ENST00000403813.2_Silent_p.I211I|KCNQ5_ENST00000370392.1_Silent_p.I211I|KCNQ5_ENST00000370398.1_Silent_p.I211I|KCNQ5_ENST00000355635.3_Silent_p.I211I	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	211					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TTGTTCTTATCGCTTCAATAG	0.408000													15	12					0	0	0.006122	0	0
NOTCH4	4855	broad.mit.edu	37	6	32170339	32170339	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:32170339G>A	ENST00000375023.3	-	21	3407	c.3269C>T	c.(3268-3270)tCc>tTc	p.S1090F		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1090	EGF-like 28.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GAAGCCGCAGGAAGGGGCCCT	0.612000													101	107					0	0	0.003610	0	0
SDK1	221935	broad.mit.edu	37	7	4152926	4152926	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:4152926G>A	ENST00000404826.2	+	24	3579	c.3440G>A	c.(3439-3441)cGa>cAa	p.R1147Q	SDK1_ENST00000389531.3_Missense_Mutation_p.R1147Q	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1147	Fibronectin type-III 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TTTAGATTTCGAATGAAGCAA	0.537000													138	131					0	0	0.003610	0	0
ZNF732	654254	broad.mit.edu	37	4	266152	266152	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:266152C>T	ENST00000419098.1	-	4	504	c.494G>A	c.(493-495)gGa>gAa	p.G165E		NM_001137608.1	NP_001131080.1	B4DXR9	ZN732_HUMAN	zinc finger protein 732	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(2)	3						GTGTTTCTCTCCAGTATGTCT	0.358000													3	6					0	0	0.004672	0	0
INPP5J	27124	broad.mit.edu	37	22	31522677	31522677	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:31522677G>A	ENST00000331075.5	+	4	1513	c.1464G>A	c.(1462-1464)atG>atA	p.M488I	INPP5J_ENST00000405300.1_Missense_Mutation_p.M121I|INPP5J_ENST00000412277.2_Missense_Mutation_p.M421I|INPP5J_ENST00000400294.2_Missense_Mutation_p.M121I|INPP5J_ENST00000404390.3_Missense_Mutation_p.M120I			Q15735	PI5PA_HUMAN	inositol polyphosphate-5-phosphatase J	488	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	12						AGCTGTTCATGGATGCGCTAG	0.607000													31	85					0	0	0.003271	0	0
GCK	2645	broad.mit.edu	37	7	44189363	44189363	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:44189363G>A	ENST00000403799.3	-	6	1144	c.675C>T	c.(673-675)atC>atT	p.I225I	GCK_ENST00000395796.3_Silent_p.I224I|GCK_ENST00000437084.1_Silent_p.I208I|GCK_ENST00000345378.2_Silent_p.I226I	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	225					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						CCTTACCCACGATCATGCCGA	0.567000													150	167					0	0	0.003610	0	0
SCN1A	6323	broad.mit.edu	37	2	166911222	166911222	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:166911222C>T	ENST00000423058.2	-	4	545	c.528G>A	c.(526-528)agG>agA	p.R176R	AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000375405.3_Silent_p.R176R|SCN1A_ENST00000409050.1_Silent_p.R176R|SCN1A_ENST00000303395.4_Silent_p.R176R	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	176						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AACAGAATCCCCTTGCAATAA	0.323000													3	13					0	0	0.004672	0	0
EPN3	55040	broad.mit.edu	37	17	48614370	48614370	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:48614370G>A	ENST00000268933.3	+	2	1032	c.453G>A	c.(451-453)aaG>aaA	p.K151K	EPN3_ENST00000541226.1_Silent_p.K95K|EPN3_ENST00000537145.1_Silent_p.K206K	NM_017957.2	NP_060427.2	Q9H201	EPN3_HUMAN	epsin 3	151						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			TCAAGACCAAGGAGCGCATGG	0.677000													6	3					0	0	0.001168	0	0
ZC3H13	23091	broad.mit.edu	37	13	46542938	46542938	+	Silent	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:46542938T>C	ENST00000242848.4	-	14	4089	c.3741A>G	c.(3739-3741)agA>agG	p.R1247R	ZC3H13_ENST00000378921.2_Silent_p.R203R|ZC3H13_ENST00000282007.3_Silent_p.R1247R			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1247	Ser-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCCTAGATTTTCTCTCTCCTG	0.413000													39	79					0	0	0.003214	0	0
INTS1	26173	broad.mit.edu	37	7	1517449	1517449	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:1517449G>A	ENST00000389470.4	-	35	5350	c.5351C>T	c.(5350-5352)tCc>tTc	p.S1784F	INTS1_ENST00000404767.3_Missense_Mutation_p.S1585F			Q8N201	INT1_HUMAN	integrator complex subunit 1	1585					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CAGCAGCAGGGAGCTCACCAC	0.687000													24	17					0	0	0.004656	0	0
RAD52	5893	broad.mit.edu	37	12	1034684	1034684	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:1034684C>T	ENST00000545564.1	-	7	625	c.626G>A	c.(625-627)tGg>tAg	p.W209*	RAD52_ENST00000536177.1_Missense_Mutation_p.G159R|RAD52_ENST00000430095.2_Missense_Mutation_p.G159R|RAD52_ENST00000358495.3_Missense_Mutation_p.G159R|RAD52_ENST00000539046.1_Missense_Mutation_p.G82R			P43351	RAD52_HUMAN	RAD52 homolog (S. cerevisiae)	0					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding	p.G159W(1)		central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			AGTGCATTCCCAAAACTCCTA	0.388000								Homologous recombination					19	19					0	0	0.001523	0	0
FBXO9	26268	broad.mit.edu	37	6	52943611	52943611	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:52943611C>T	ENST00000244426.6	+	4	524	c.352C>T	c.(352-354)Cgt>Tgt	p.R118C	FBXO9_ENST00000323557.7_Missense_Mutation_p.R108C|FBXO9_ENST00000370939.3_Missense_Mutation_p.R74C	NM_012347.4	NP_036479.1	Q9UK97	FBX9_HUMAN	F-box protein 9	118						ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)|large_intestine(4)|lung(1)|pancreas(2)|skin(1)	9	Lung NSC(77;0.103)					CAAGTTTTATCGTAGGGCTAT	0.368000													17	35					0	0	0.008871	0	0
CPA4	51200	broad.mit.edu	37	7	129944388	129944388	+	Missense_Mutation	SNP	C	C	G	rs141042847		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:129944388C>G	ENST00000222482.4	+	5	483	c.455C>G	c.(454-456)tCg>tGg	p.S152W	CPA4_ENST00000493259.1_Missense_Mutation_p.S48W|CPA4_ENST00000445470.2_Missense_Mutation_p.S119W	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	152					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding	p.S152L(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					ATTGGACATTCGTTTGAAAAC	0.527000													17	54					0	0	0.008871	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656466	40656466	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:40656466C>T	ENST00000406785.1	-	2	1144	c.955G>A	c.(955-957)Gat>Aat	p.D319N	SLC8A1_ENST00000542756.1_Missense_Mutation_p.D319N|SLC8A1_ENST00000542024.1_Missense_Mutation_p.D319N|SLC8A1_ENST00000408028.2_Missense_Mutation_p.D319N|SLC8A1_ENST00000405901.3_Missense_Mutation_p.D319N|SLC8A1_ENST00000405269.1_Missense_Mutation_p.D319N|SLC8A1_ENST00000403092.1_Missense_Mutation_p.D319N|SLC8A1_ENST00000402441.1_Missense_Mutation_p.D319N|SLC8A1_ENST00000332839.4_Missense_Mutation_p.D319N|SLC8A1_ENST00000406391.2_Missense_Mutation_p.D319N			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	319					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GCTTCTTCATCATCTTGGTCC	0.398000													31	53					0	0	0.002445	0	0
DNAH2	146754	broad.mit.edu	37	17	7678115	7678115	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:7678115G>A	ENST00000572933.1	+	29	6000	c.4540G>A	c.(4540-4542)Gaa>Aaa	p.E1514K	DNAH2_ENST00000389173.2_Missense_Mutation_p.E1514K			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1514	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TACAATCCTGGAAGATATTCA	0.448000													10	29					0	0	0.000978	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				15	24					0	0	0.004990	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458667	20458667	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:20458667C>T	ENST00000426804.1	-	1	3119	c.2635G>A	c.(2635-2637)Ggg>Agg	p.G879R		NM_015672.1	NP_056487.1			RIMS binding protein 3											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			TCAAGCTCCCCCTCATAGAAG	0.592000													4	11					0	0	0.000602	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140764776	140764776	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140764776C>T	ENST00000518325.1	+	1	2310	c.2310C>T	c.(2308-2310)ttC>ttT	p.F770F	PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTGATCTTCCCCCAGCCCA	0.512000													38	38					0	0	0.003610	0	0
STAT4	6775	broad.mit.edu	37	2	191905853	191905853	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:191905853C>T	ENST00000392320.2	-	15	1587	c.1273G>A	c.(1273-1275)Gaa>Aaa	p.E425K	STAT4_ENST00000358470.4_Missense_Mutation_p.E425K|STAT4_ENST00000470708.1_5'UTR	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	425					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GAATGAAGTTCTTCAGTCACC	0.363000													24	52					0	0	0.003954	0	0
NLRP7	199713	broad.mit.edu	37	19	55452999	55452999	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:55452999G>A	ENST00000446217.1	-	4	567	c.165C>T	c.(163-165)tcC>tcT	p.S55S	NLRP7_ENST00000590030.1_Silent_p.S27S|NLRP7_ENST00000448121.2_Silent_p.S27S|NLRP7_ENST00000592784.1_Silent_p.S27S|NLRP7_ENST00000340844.2_Silent_p.S27S|NLRP7_ENST00000588756.1_Silent_p.S27S|NLRP7_ENST00000328092.5_Silent_p.S27S			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	27	DAPIN.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		CCCATAAAAGGGATTTGAAAC	0.502000													10	27					0	0	0.000978	0	0
OR5T1	390155	broad.mit.edu	37	11	56043514	56043514	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:56043514C>T	ENST00000313033.2	+	1	486	c.400C>T	c.(400-402)Cgc>Tgc	p.R134C		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R134S(1)		NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					GGCTTATGATCGCTATGTAGC	0.413000													26	102					0	0	0.003954	0	0
PIGO	84720	broad.mit.edu	37	9	35092421	35092421	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:35092421G>A	ENST00000378617.3	-	7	1857	c.1463C>T	c.(1462-1464)gCc>gTc	p.A488V	PIGO_ENST00000361778.2_Intron|PIGO_ENST00000341666.3_Missense_Mutation_p.A488V|PIGO_ENST00000298004.5_Intron	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	488					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CAGGCCCCAGGCCACAGGTGT	0.562000													18	24					0	0	0.008871	0	0
DOPEY2	9980	broad.mit.edu	37	21	37623502	37623502	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr21:37623502G>A	ENST00000399151.3	+	22	5126	c.5041G>A	c.(5041-5043)Gcc>Acc	p.A1681T		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1681					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CCCCTTGACGGCCCATCTTGG	0.413000													17	70					0	0	0.006122	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655879	46655879	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:46655879C>T	ENST00000253255.5	-	1	3340	c.3341G>A	c.(3340-3342)tGg>tAg	p.W1114*		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1114					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ACCCTCTCTCCATTCACTCTG	0.488000													16	40					0	0	0.006122	0	0
ZNF441	126068	broad.mit.edu	37	19	11892313	11892313	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:11892313C>T	ENST00000357901.4	+	4	1776	c.1674C>T	c.(1672-1674)ccC>ccT	p.P558P	ZNF441_ENST00000454339.2_Silent_p.P491P	NM_152355.2	NP_689568.2	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GAGAGAAACCCTATGGTTGTC	0.413000													9	13					0	0	0.000978	0	0
MYH2	4620	broad.mit.edu	37	17	10430031	10430031	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:10430031C>T	ENST00000245503.5	-	30	4456	c.4072G>A	c.(4072-4074)Gaa>Aaa	p.E1358K	MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.E1358K|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1358					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCCTTGGATTCCTGCTCCTCC	0.607000													37	29					0	0	0.006999	0	0
THSD7B	80731	broad.mit.edu	37	2	137852477	137852477	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:137852477C>T	ENST00000409968.1	+	4	1163	c.985C>T	c.(985-987)Cag>Tag	p.Q329*	THSD7B_ENST00000543459.1_Nonsense_Mutation_p.Q188*|THSD7B_ENST00000413152.2_Nonsense_Mutation_p.Q298*|THSD7B_ENST00000272643.3_Nonsense_Mutation_p.Q329*					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATTGACTGTTCAGTCCTGCAT	0.458000													7	99					0	0	0.004482	0	0
IPO5	3843	broad.mit.edu	37	13	98645159	98645159	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:98645159C>T	ENST00000261574.5	+	10	917	c.737C>T	c.(736-738)tCg>tTg	p.S246L	IPO5_ENST00000539640.1_Missense_Mutation_p.S103L|IPO5_ENST00000490680.1_Missense_Mutation_p.S228L	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	228					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						GTAAATGACTCGTGCTACCAG	0.408000													23	57					0	0	0.003330	0	0
DYNC1LI2	1783	broad.mit.edu	37	16	66770096	66770096	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:66770096G>A	ENST00000258198.2	-	5	787	c.581C>T	c.(580-582)tCc>tTc	p.S194F	DYNC1LI2_ENST00000379482.2_Intron|DYNC1LI2_ENST00000443351.2_Missense_Mutation_p.S117F|DYNC1LI2_ENST00000440564.2_Missense_Mutation_p.S155F	NM_006141.2	NP_006132.1	O43237	DC1L2_HUMAN	dynein, cytoplasmic 1, light intermediate chain 2	194					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(4)|stomach(1)	15		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		TCTCTGTGGGGAACCTTGACA	0.453000													16	34					0	0	0.003163	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338177	13338177	+	RNA	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:13338177C>T	ENST00000602906.1	+	0	195																				kidney(3)|lung(1)	4						TTGCCCAACTCATGTCTCTTA	0.418000													10	23					0	0	0.008291	0	0
DCC	1630	broad.mit.edu	37	18	50278518	50278518	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:50278518C>T	ENST00000442544.2	+	2	802	c.186C>T	c.(184-186)tcC>tcT	p.S62S		NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	62	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCGACTGCTCCGCGGAGTCCG	0.502000													15	13					0	0	0.003163	0	0
TRAV12-3	28672	broad.mit.edu	37	14	22434132	22434132	+	RNA	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:22434132C>T	ENST00000390442.3	+	0	241																											AGACAGTATTCCAGAAAAGGC	0.448000													46	51					0	0	0.003610	0	0
LARP4	113251	broad.mit.edu	37	12	50860821	50860821	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:50860821C>T	ENST00000398473.2	+	13	1575	c.1463C>T	c.(1462-1464)cCt>cTt	p.P488L	LARP4_ENST00000347328.5_Missense_Mutation_p.P417L|LARP4_ENST00000429001.3_Missense_Mutation_p.P494L|LARP4_ENST00000293618.8_Missense_Mutation_p.P417L|LARP4_ENST00000518444.1_Missense_Mutation_p.P487L	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	488							nucleotide binding|RNA binding	p.P488L(1)		breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						CCACCTTTACCTGGAAGTTCA	0.383000													25	19					0	0	0.002780	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480591	140480591	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140480591G>A	ENST00000231130.2	+	1	358	c.358G>A	c.(358-360)Gag>Aag	p.E120K	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		120	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGTTACAAACGAGCTCCGTAT	0.418000													30	35					0	0	0.006320	0	0
TNFSF10	8743	broad.mit.edu	37	3	172224494	172224494	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:172224494T>C	ENST00000241261.2	-	5	756	c.634A>G	c.(634-636)Aaa>Gaa	p.K212E	TNFSF10_ENST00000420541.2_3'UTR	NM_003810.3	NP_003801.1	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily, member 10	212					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			breast(2)|cervix(1)|large_intestine(1)|lung(6)|ovary(1)|skin(4)	15	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CTTGTGTATTTGTAAATATAT	0.328000													31	38					0	0	0.001786	0	0
DNAH5	1767	broad.mit.edu	37	5	13753560	13753560	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:13753560C>T	ENST00000265104.4	-	63	10758	c.10654G>A	c.(10654-10656)Gcc>Acc	p.A3552T		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3552					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATTTTCCGGGCTTTCATTTCC	0.408000									Kartagener syndrome				33	95					0	0	0.004289	0	0
GMPPA	29926	broad.mit.edu	37	2	220366281	220366281	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:220366281G>A	ENST00000358215.3	+	4	591	c.222G>A	c.(220-222)caG>caA	p.Q74Q	AC053503.11_ENST00000429882.1_RNA|GMPPA_ENST00000373908.1_Silent_p.Q74Q|GMPPA_ENST00000373917.3_Silent_p.Q74Q|GMPPA_ENST00000341142.3_Silent_p.Q74Q|GMPPA_ENST00000313597.5_Silent_p.Q74Q	NM_205847.2	NP_995319.1	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	74					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		CCGCCCAGCAGGAGTTTAACC	0.547000													36	46					0	0	0.004878	0	0
RAB39B	116442	broad.mit.edu	37	X	154490183	154490183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:154490183G>A	ENST00000369454.3	-	2	847	c.547C>T	c.(547-549)Cag>Tag	p.Q183*		NM_171998.2	NP_741995.1	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	183					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding			breast(1)|central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(12)	19	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CAGCCCTCCTGGATTGTAATC	0.463000													29	56					0	0	0.006320	0	0
EPPK1	83481	broad.mit.edu	37	8	144940534	144940534	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:144940534G>A	ENST00000525985.1	-	2	6959	c.6888C>T	c.(6886-6888)atC>atT	p.I2296I				P58107	EPIPL_HUMAN	epiplakin 1	2296						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTTCTCCTGGATCTCGCCGC	0.701000													7	75					0	0	0.003080	0	0
WRN	7486	broad.mit.edu	37	8	30948414	30948414	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:30948414C>T	ENST00000298139.5	+	15	2034	c.1785C>T	c.(1783-1785)atC>atT	p.I595I		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	595	Helicase ATP-binding.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		GCCTTGTTATCTCTCCCCTTA	0.353000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				12	52					0	0	0.003163	0	0
AP4M1	9179	broad.mit.edu	37	7	99704431	99704431	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:99704431C>T	ENST00000429084.1	+	15	1467	c.1309C>T	c.(1309-1311)Cca>Tca	p.P437S	AP4M1_ENST00000422582.1_Missense_Mutation_p.P302S|AP4M1_ENST00000421755.1_Missense_Mutation_p.P430S|AP4M1_ENST00000359593.4_Missense_Mutation_p.P430S			O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	430	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGCCTTCAGGCCATGCGGCAA	0.647000													5	31					0	0	0.001168	0	0
C1orf56	54964	broad.mit.edu	37	1	151020995	151020995	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:151020995G>A	ENST00000368926.5	+	1	780	c.672G>A	c.(670-672)ggG>ggA	p.G224G		NM_017860.3	NP_060330.2	Q9BUN1	CA056_HUMAN	chromosome 1 open reading frame 56	224						extracellular region				endometrium(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCCGGTCTGGGAAGCTGCACG	0.657000											OREG0013793	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	53					0	0	0.001882	0	0
NKG7	4818	broad.mit.edu	37	19	51875055	51875055	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:51875055G>A	ENST00000221978.5	-	4	653	c.474C>T	c.(472-474)ccC>ccT	p.P158P	NKG7_ENST00000595217.1_3'UTR|NKG7_ENST00000600427.1_Silent_p.P78P	NM_005601.3	NP_005592.1	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	158						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AGCCAGGACGGGGACCGCCAC	0.582000													27	119					0	0	0.002096	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54930841	54930841	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:54930841G>A	ENST00000474759.1	+	26	2360	c.2312G>A	c.(2311-2313)cGa>cAa	p.R771Q	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.R677Q|CACNA2D3-AS1_ENST00000471265.1_RNA|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.R771Q|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.R771Q	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	771						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CTCTGGTACCGAAGAGCCGCT	0.522000													39	47					0	0	0.006230	0	0
NPAS4	266743	broad.mit.edu	37	11	66191325	66191325	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:66191325C>T	ENST00000311034.2	+	7	1140	c.964C>T	c.(964-966)Ctc>Ttc	p.L322F		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	322					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						AGCCTGGAGCCTCCGCCAGCA	0.547000													23	53					0	0	0.003330	0	0
NEDD4L	23327	broad.mit.edu	37	18	56024451	56024451	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:56024451C>T	ENST00000456986.1	+	19	1971	c.1371C>T	c.(1369-1371)gaC>gaT	p.D457D	NEDD4L_ENST00000586263.1_Silent_p.D550D|NEDD4L_ENST00000435432.2_Silent_p.D437D|NEDD4L_ENST00000431212.2_Silent_p.D457D|NEDD4L_ENST00000400345.3_Silent_p.D578D|NEDD4L_ENST00000456173.2_Silent_p.D437D|NEDD4L_ENST00000382850.4_Silent_p.D558D|NEDD4L_ENST00000589054.1_Intron|NEDD4L_ENST00000256830.9_Silent_p.D474D|NEDD4L_ENST00000256832.7_Silent_p.D437D|NEDD4L_ENST00000356462.6_Silent_p.D514D|NEDD4L_ENST00000357895.5_Silent_p.D570D	NM_001144964.1	NP_001138436.1	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	578					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			breast(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(11)|ovary(1)|prostate(4)	37						AGTGGGAAGACCCAAGACTGC	0.328000													11	9					0	0	0.008291	0	0
ANO10	55129	broad.mit.edu	37	3	43602729	43602729	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:43602729C>T	ENST00000292246.3	-	9	1629	c.1459G>A	c.(1459-1461)Gaa>Aaa	p.E487K	ANO10_ENST00000350459.4_Missense_Mutation_p.E297K|ANO10_ENST00000396091.3_Missense_Mutation_p.E421K|ANO10_ENST00000414522.2_Missense_Mutation_p.E487K|ANO10_ENST00000451430.2_Missense_Mutation_p.E376K	NM_018075.3	NP_060545.3	Q9NW15	ANO10_HUMAN	anoctamin 10	487					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						GTTCCCATTTCTTTTTCCAGG	0.383000													25	38					0	0	0.007291	0	0
PGM5	5239	broad.mit.edu	37	9	71098840	71098840	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:71098840C>T	ENST00000396396.1	+	9	1584	c.1355C>T	c.(1354-1356)gCc>gTc	p.A452V		NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	452					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						GACCTGGAGGCCCTGGTCACA	0.507000													20	18					0	0	0.001882	0	0
NID2	22795	broad.mit.edu	37	14	52496283	52496283	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:52496283C>T	ENST00000216286.5	-	10	2382	c.2383G>A	c.(2383-2385)Gat>Aat	p.D795N	NID2_ENST00000541773.1_Missense_Mutation_p.D742N	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	795	EGF-like 2.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					TTCCGTCCATCTCCCTGGTAC	0.527000													27	54					0	0	0.007291	0	0
ZNF385D	79750	broad.mit.edu	37	3	21465456	21465456	+	Splice_Site	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:21465456C>T	ENST00000281523.2	-	7	1471	c.954_splice	c.e7+1	p.G318_splice		NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	318						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						GACACTCACCCCCAGTGGATG	0.458000													10	51					0	0	0.006214	0	0
AAMP	14	broad.mit.edu	37	2	219131697	219131697	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:219131697G>A	ENST00000248450.4	-	4	577	c.407C>T	c.(406-408)tCt>tTt	p.S136F	AAMP_ENST00000444053.1_Missense_Mutation_p.S137F|AAMP_ENST00000420660.1_Missense_Mutation_p.S117F			Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	136					angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(4)|ovary(2)|skin(1)	11		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACAAGTCACAGAGTCTTTATG	0.507000													11	26					0	0	0.000978	0	0
FOLH1B	219595	broad.mit.edu	37	11	89431799	89431799	+	RNA	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:89431799G>A	ENST00000532352.1	+	0	2081							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						TATTGAATTTGTGTGGTATGT	0.328000													6	15					0	0	0.001168	0	0
VCAM1	7412	broad.mit.edu	37	1	101200183	101200183	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:101200183G>A	ENST00000294728.2	+	8	2019	c.1918G>A	c.(1918-1920)Gag>Aag	p.E640K	VCAM1_ENST00000370115.1_Missense_Mutation_p.E441K|VCAM1_ENST00000370119.4_Missense_Mutation_p.E578K|VCAM1_ENST00000347652.2_Missense_Mutation_p.E548K	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	640	Ig-like C2-type 7.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GAAAAAAGCGGAGACAGGAGA	0.413000													8	14					0	0	0.004482	0	0
TIMP1	7076	broad.mit.edu	37	X	47444746	47444746	+	Missense_Mutation	SNP	C	C	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:47444746C>G	ENST00000377018.2	+	3	679	c.115C>G	c.(115-117)Cgc>Ggc	p.R39G	TIMP1_ENST00000218388.4_Intron|SYN1_ENST00000295987.7_Intron|SYN1_ENST00000340666.4_Intron|TIMP1_ENST00000456754.2_Missense_Mutation_p.P115R|TIMP1_ENST00000377017.1_Intron			P01033	TIMP1_HUMAN	TIMP metallopeptidase inhibitor 1	0	NTR.				erythrocyte maturation|negative regulation of membrane protein ectodomain proteolysis|platelet activation|platelet degranulation|positive regulation of cell proliferation	platelet alpha granule lumen	metal ion binding|metalloendopeptidase inhibitor activity|protein binding			endometrium(1)|large_intestine(2)	3						GCACCGTCCCCGCGCCCTGTG	0.647000													5	25					0	0	0.000602	0	0
FAT3	120114	broad.mit.edu	37	11	92085755	92085755	+	Silent	SNP	A	A	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:92085755A>C	ENST00000298047.6	+	1	494	c.477A>C	c.(475-477)tcA>tcC	p.S159S	FAT3_ENST00000541502.1_Silent_p.S159S|FAT3_ENST00000409404.2_Silent_p.S159S|FAT3_ENST00000525166.1_Silent_p.S9S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	159	Cadherin 2.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTTTGTTTTCACCCACAACAT	0.413000										TCGA Ovarian(4;0.039)			125	176					0	0	0.003610	0	0
FAHD2A	51011	broad.mit.edu	37	2	96072778	96072778	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:96072778G>A	ENST00000233379.4	+	3	488	c.335G>A	c.(334-336)gGc>gAc	p.G112D	FAHD2A_ENST00000447036.1_Missense_Mutation_p.G112D	NM_016044.2	NP_057128.2	Q96GK7	FAH2A_HUMAN	fumarylacetoacetate hydrolase domain containing 2A	112							hydrolase activity|metal ion binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(3)|ovary(1)	8						GTGTGTGTGGGCATGAATTAT	0.567000													4	57					0	0	0.000602	0	0
ZNF100	163227	broad.mit.edu	37	19	21909497	21909497	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:21909497G>A	ENST00000358296.6	-	5	1815	c.1617C>T	c.(1615-1617)acC>acT	p.T539T	ZNF100_ENST00000305570.6_Silent_p.T475T	NM_173531.3	NP_775802.2	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	539					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	21						ACATTTGTAGGGTTTCTCTCC	0.368000													12	17					0	0	0.000978	0	0
EMD	2010	broad.mit.edu	37	X	153608118	153608118	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:153608118C>T	ENST00000369842.4	+	2	439	c.151C>T	c.(151-153)Ccc>Tcc	p.P51S	EMD_ENST00000369835.3_Intron|EMD_ENST00000492448.1_3'UTR	NM_000117.2	NP_000108.1	P50402	EMD_HUMAN	emerin	51	Interaction with F-actin (Probable).				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding			lung(5)	5	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTCTCGCCCCCCAGCTCGTC	0.672000													12	34					0	0	0.000978	0	0
SLC4A4	8671	broad.mit.edu	37	4	72413422	72413422	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:72413422G>A	ENST00000340595.3	+	17	2743	c.2547G>A	c.(2545-2547)atG>atA	p.M849I	SLC4A4_ENST00000264485.5_Missense_Mutation_p.M893I|SLC4A4_ENST00000351898.6_Intron|SLC4A4_ENST00000425175.1_Missense_Mutation_p.M893I	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	893						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CAGTCTTTATGGCTCCCATCT	0.388000													28	58					0	0	0.008361	0	0
TRPC7	57113	broad.mit.edu	37	5	135692902	135692902	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:135692902C>T	ENST00000513104.1	-	2	456	c.174G>A	c.(172-174)gtG>gtA	p.V58V	TRPC7_ENST00000355180.3_Silent_p.V58V|TRPC7_ENST00000426057.2_Silent_p.V58V	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	58					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TTTTCCGGACCACCGGGATGT	0.602000													25	77					0	0	0.007291	0	0
ZNF786	136051	broad.mit.edu	37	7	148769065	148769065	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:148769065G>A	ENST00000316286.9	-	3	813	c.541C>T	c.(541-543)Ccc>Tcc	p.P181S	ZNF786_ENST00000451334.3_Missense_Mutation_p.P230S|ZNF786_ENST00000491431.1_Missense_Mutation_p.P267S			Q8N393	ZN786_HUMAN	zinc finger protein 786	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(2)	26	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TTCCGGAAGGGGCCCCTCCCC	0.682000													7	11					0	0	0.003080	0	0
PREX2	80243	broad.mit.edu	37	8	68999972	68999972	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:68999972C>T	ENST00000288368.4	+	19	2318	c.2041C>T	c.(2041-2043)Cca>Tca	p.P681S	RP11-403D15.2_ENST00000526901.1_RNA|PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	681	PDZ 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AGTGAAAATTCCAGATTCAGC	0.428000													17	50					0	0	0.001523	0	0
CEP89	84902	broad.mit.edu	37	19	33444550	33444550	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:33444550C>T	ENST00000305768.4	-	4	551	c.463G>A	c.(463-465)Gac>Aac	p.D155N	CEP89_ENST00000590597.1_Missense_Mutation_p.D155N	NM_032816.3	NP_116205.3	Q96ST8	CEP89_HUMAN	centrosomal protein 89kDa	155						centrosome|spindle pole				breast(2)|cervix(1)|endometrium(4)|large_intestine(4)|lung(15)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	35						GCGTACAGGTCATCACTGTGG	0.488000													12	376					0	0	0.001523	0	0
CYP4F2	8529	broad.mit.edu	37	19	15990464	15990464	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:15990464T>C	ENST00000221700.5	-	11	1359	c.1264A>G	c.(1264-1266)Atc>Gtc	p.I422V	CYP4F2_ENST00000592328.1_Missense_Mutation_p.I422V	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	422					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AAAACACTGATGAGGCAGATA	0.597000													35	48					0	0	0.004878	0	0
TESPA1	9840	broad.mit.edu	37	12	55356694	55356694	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:55356694G>A	ENST00000524622.1	-	7	1235	c.574C>T	c.(574-576)Ctc>Ttc	p.L192F	TESPA1_ENST00000316577.8_Missense_Mutation_p.L330F|TESPA1_ENST00000531122.1_Missense_Mutation_p.L192F|TESPA1_ENST00000449076.1_Missense_Mutation_p.L330F|TESPA1_ENST00000532804.1_Missense_Mutation_p.L192F	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	330																	TCTTGCTGGAGGAACTGCTTC	0.522000													5	22					0	0	0.001168	0	0
ITGB3	3690	broad.mit.edu	37	17	45360877	45360877	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:45360877A>G	ENST00000559488.1	+	3	339	c.323A>G	c.(322-324)cAa>cGa	p.Q108R	ITGB3_ENST00000571680.1_Missense_Mutation_p.Q108R|ITGB3_ENST00000560629.1_Silent_p.S96S|ITGB3_ENST00000435993.2_Missense_Mutation_p.Q61R	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	108					activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	CAGGTCACTCAAGTCAGTCCC	0.612000													17	26					0	0	0.006122	0	0
CEACAM6	4680	broad.mit.edu	37	19	42270134	42270134	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:42270134G>A	ENST00000199764.6	+	5	1220	c.1002G>A	c.(1000-1002)acG>acA	p.T334T	AC011513.4_ENST00000601409.1_RNA	NM_002483.4	NP_002474.3	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	334					cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				breast(1)|kidney(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		TCGGCATCACGATTGGAGTGC	0.522000													11	50					0	0	0.002450	0	0
RBP3	5949	broad.mit.edu	37	10	48390817	48390817	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr10:48390817G>A	ENST00000224600.4	-	1	174	c.61C>T	c.(61-63)Cac>Tac	p.H21Y		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	21	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	TGGAACAGGTGTGTGGGGCCA	0.607000													14	21					0	0	0.002450	0	0
PALMD	54873	broad.mit.edu	37	1	100155218	100155218	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:100155218C>T	ENST00000263174.4	+	7	1777	c.1402C>T	c.(1402-1404)Ccc>Tcc	p.P468S	PALMD_ENST00000605497.1_Missense_Mutation_p.P468S	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	468					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		CCCCATAGCTCCCCATAGTCA	0.478000													6	7					0	0	0.001984	0	0
OR5M11	219487	broad.mit.edu	37	11	56310479	56310479	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:56310479G>A	ENST00000528616.2	-	1	278	c.255C>T	c.(253-255)atC>atT	p.I85I		NM_001005245.1	NP_001005245.1	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M, member 11	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)	18						TCTCAGATACGATATTAGTCG	0.448000													22	28					0	0	0.001882	0	0
OR5T1	390155	broad.mit.edu	37	11	56044034	56044034	+	Missense_Mutation	SNP	A	A	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:56044034A>T	ENST00000313033.2	+	1	1006	c.920A>T	c.(919-921)aAa>aTa	p.K307I		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					TTGCGGAACAAAGATGTAAAG	0.348000													26	38					0	0	0.005443	0	0
TENM1	10178	broad.mit.edu	37	X	123657238	123657238	+	Missense_Mutation	SNP	C	C	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:123657238C>A	ENST00000422452.2	-	17	3072	c.3009G>T	c.(3007-3009)agG>agT	p.R1003S	TENM1_ENST00000371130.3_Missense_Mutation_p.R1003S	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CAATAGTTCCCCTCTCTGGAC	0.433000													30	56					1.39806e-14	4.31156e-14	0.008361	1	0
ZMAT1	84460	broad.mit.edu	37	X	101139525	101139525	+	Missense_Mutation	SNP	T	T	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:101139525T>G	ENST00000458570.1	-	9	1691	c.361A>C	c.(361-363)Aag>Cag	p.K121Q	ZMAT1_ENST00000540921.1_Missense_Mutation_p.K292Q|ZMAT1_ENST00000494068.1_5'UTR|ZMAT1_ENST00000372782.3_Missense_Mutation_p.K292Q			A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	121						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						GGTAACTGCTTTTCCATTGCT	0.403000													27	103					0	0	0.006320	0	0
DRAM2	128338	broad.mit.edu	37	1	111660801	111660801	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:111660801A>G	ENST00000286692.4	-	9	1399	c.782T>C	c.(781-783)cTa>cCa	p.L261P	DRAM2_ENST00000539140.1_Missense_Mutation_p.L261P|DRAM2_ENST00000484310.1_5'UTR			Q6UX65	DRAM2_HUMAN	DNA-damage regulated autophagy modulator 2	261					apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane				endometrium(1)|large_intestine(5)|lung(3)	9						TCTGGAAAGTAGCCGTGTTCG	0.378000													20	39					0	0	0.001882	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105915055	105915055	+	Missense_Mutation	SNP	C	C	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:105915055C>G	ENST00000393359.2	-	3	1222	c.796G>C	c.(796-798)Gaa>Caa	p.E266Q	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.E266Q			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	266	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						GTGATGAATTCGTCATCGAGC	0.542000													25	66					0	0	0.007291	0	0
SPRY3	10251	broad.mit.edu	37	X	155004376	155004376	+	Silent	SNP	C	C	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:155004376C>A	ENST00000302805.2	+	2	1274	c.843C>A	c.(841-843)ccC>ccA	p.P281P		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	281					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane						all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CACCCTTCCCCAAGGCCCAGG	0.547000													28	42					3.73148e-12	1.14786e-11	0.007291	1	0
CCDC83	220047	broad.mit.edu	37	11	85576199	85576199	+	Silent	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:85576199T>C	ENST00000280245.4	+	2	545	c.33T>C	c.(31-33)gaT>gaC	p.D11D	CCDC83_ENST00000342404.3_Silent_p.D11D|CCDC83_ENST00000376067.1_5'UTR	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	11										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				ATAAAAAGGATACACATGACG	0.363000													20	61					0	0	0.002780	0	0
FSTL5	56884	broad.mit.edu	37	4	162841651	162841651	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:162841651C>T	ENST00000306100.5	-	4	750	c.314G>A	c.(313-315)gGa>gAa	p.G105E	FSTL5_ENST00000536695.1_Missense_Mutation_p.G104E|FSTL5_ENST00000427802.2_Missense_Mutation_p.G104E|FSTL5_ENST00000379164.4_Missense_Mutation_p.G104E	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	105	Kazal-like.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATAGAATTCTCCGTCAGATCC	0.433000													14	21					0	0	0.001855	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55378096	55378096	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr19:55378096C>T	ENST00000326321.3	+	9	1311	c.1278C>T	c.(1276-1278)agC>agT	p.S426S	KIR3DL2_ENST00000270442.5_Silent_p.S409S|KIR3DL1_ENST00000402254.2_Silent_p.S426S	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	426					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		CAGATACCAGCGTGTACACGG	0.522000													78	101					0	0	0.003610	0	0
PCNX	22990	broad.mit.edu	37	14	71570253	71570253	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:71570253C>T	ENST00000304743.2	+	32	6408	c.5962C>T	c.(5962-5964)Cct>Tct	p.P1988S	PCNX_ENST00000439984.3_Missense_Mutation_p.P1877S|PCNX_ENST00000238570.5_Missense_Mutation_p.P1916S|PCNX_ENST00000556272.1_3'UTR	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1988						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TTGTGATCAACCTATTGGCTA	0.453000													20	59					0	0	0.002299	0	0
GALR1	2587	broad.mit.edu	37	18	74963119	74963119	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:74963119C>T	ENST00000299727.3	+	1	615	c.615C>T	c.(613-615)ttC>ttT	p.F205F		NM_001480.3	NP_001471.2	P47211	GALR1_HUMAN	galanin receptor 1	205					digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		TGTGCACCTTCGTCTTCGGCT	0.687000													10	70					0	0	0.001368	0	0
ERAP2	64167	broad.mit.edu	37	5	96225001	96225001	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:96225001C>T	ENST00000437043.3	+	5	1673	c.962C>T	c.(961-963)tCc>tTc	p.S321F	ERAP2_ENST00000379904.4_Missense_Mutation_p.S276F|ERAP2_ENST00000510309.1_Missense_Mutation_p.S321F|CTD-2260A17.2_ENST00000501338.1_Intron	NM_001130140.1|NM_022350.3	NP_001123612.1|NP_071745.1	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	321					antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		TATCCACTCTCCAAACTGGGT	0.353000													20	46					0	0	0.001882	0	0
SLC22A6	9356	broad.mit.edu	37	11	62751836	62751836	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:62751836C>T	ENST00000377871.3	-	1	593	c.327G>A	c.(325-327)tgG>tgA	p.W109*	SLC22A6_ENST00000458333.2_Nonsense_Mutation_p.W109*|SLC22A6_ENST00000360421.4_Nonsense_Mutation_p.W109*|SLC22A6_ENST00000421062.2_Nonsense_Mutation_p.W109*	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	109					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						TGTCATAGATCCAGCCATCGG	0.602000													16	49					0	0	0.004990	0	0
HAPLN1	1404	broad.mit.edu	37	5	82948574	82948574	+	Missense_Mutation	SNP	A	A	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:82948574A>T	ENST00000274341.4	-	3	1020	c.170T>A	c.(169-171)gTt>gAt	p.V57D	HAPLN1_ENST00000514416.1_Missense_Mutation_p.V57D	NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	57	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		TGGCAGTGTAACATTGCCACC	0.398000													17	25					0	0	0.004990	0	0
HAPLN1	1404	broad.mit.edu	37	5	82948575	82948575	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:82948575C>T	ENST00000274341.4	-	3	1019	c.169G>A	c.(169-171)Gtt>Att	p.V57I	HAPLN1_ENST00000514416.1_Missense_Mutation_p.V57I	NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	57	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		GGCAGTGTAACATTGCCACCT	0.393000													17	26					0	0	0.004990	0	0
TRMT44	152992	broad.mit.edu	37	4	8469649	8469649	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:8469649C>T	ENST00000389737.4	+	9	1503	c.1503C>T	c.(1501-1503)ctC>ctT	p.L501L	TRMT44_ENST00000513449.2_Silent_p.L260L	NM_152544.2	NP_689757.2			tRNA methyltransferase 44 homolog (S. cerevisiae)																		AGGTCTGTCTCGTTGGAAAAT	0.468000													5	50					0	0	0.001984	0	0
RASGRP3	25780	broad.mit.edu	37	2	33774770	33774770	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:33774770G>A	ENST00000403687.3	+	14	2234	c.1494G>A	c.(1492-1494)caG>caA	p.Q498Q	RASGRP3_ENST00000402538.3_Silent_p.Q498Q|RASGRP3_ENST00000407811.1_Silent_p.Q497Q	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	498					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					ATAATTTTCAGGAGATGACCT	0.403000													13	20					0	0	0.001368	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114107564	114107564	+	Silent	SNP	G	G	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:114107564G>T	ENST00000375418.3	-	1	275	c.189C>A	c.(187-189)atC>atA	p.I63I		NM_138430.3	NP_612439.2	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1	63					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	11	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			CGGCGGTTGCGATGTGCATGA	0.642000													13	37					4.7546e-09	1.45888e-08	0.004007	1	0
PCDHA9	9752	broad.mit.edu	37	5	140229320	140229320	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140229320G>A	ENST00000378122.3	+	1	1964	c.1240G>A	c.(1240-1242)Gac>Aac	p.D414N	PCDHA9_ENST00000532602.1_Missense_Mutation_p.D414N|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAGCTCTGGACCGCGAGAG	0.642000													14	69					0	0	0.004007	0	0
UNC5C	8633	broad.mit.edu	37	4	96222867	96222867	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:96222867G>A	ENST00000453304.1	-	3	728	c.380C>T	c.(379-381)tCg>tTg	p.S127L	UNC5C_ENST00000506749.1_Missense_Mutation_p.S127L|UNC5C_ENST00000504962.1_Missense_Mutation_p.S127L	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	127	Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TTGCTGGCGCGAAATCTCAAT	0.463000													12	19					0	0	0.001368	0	0
PREPL	9581	broad.mit.edu	37	2	44570899	44570899	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:44570899T>C	ENST00000541738.1	-	4	720	c.334A>G	c.(334-336)Aat>Gat	p.N112D	PREPL_ENST00000409272.1_Missense_Mutation_p.N201D|PREPL_ENST00000409957.1_Missense_Mutation_p.N112D|PREPL_ENST00000410081.1_Missense_Mutation_p.N201D|PREPL_ENST00000409936.1_Missense_Mutation_p.N201D|PREPL_ENST00000409411.1_Missense_Mutation_p.N112D|PREPL_ENST00000378511.3_Missense_Mutation_p.N201D|PREPL_ENST00000378520.3_Missense_Mutation_p.N201D|PREPL_ENST00000260648.6_Missense_Mutation_p.N201D	NM_001171617.1	NP_001165088.1	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like	201					proteolysis	cytosol	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(19)|ovary(1)|prostate(1)|skin(2)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGGACACATTCGGGAAAGAA	0.423000													13	56					0	0	0.004007	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132905758	132905758	+	Silent	SNP	C	C	T	rs62165773	by1000genomes	TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:132905758C>T	ENST00000409867.1	-	6	972	c.723G>A	c.(721-723)gcG>gcA	p.A241A	ANKRD30BL_ENST00000470729.1_5'UTR					ankyrin repeat domain 30B-like											endometrium(1)|kidney(3)	4						GTGTTCTTTCCGCCAAGGGTG	0.438000													5	21					0	0	0.001168	0	0
LELP1	149018	broad.mit.edu	37	1	153177316	153177316	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:153177316G>A	ENST00000368747.1	+	2	243	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K		NM_001010857.1	NP_001010857.1	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	45	Cys/Pro-rich.									NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|pancreas(1)|prostate(1)	19	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACGCTGTTTCGAAAAGTGCCC	0.572000													19	49					0	0	0.002299	0	0
BRCA2	675	broad.mit.edu	37	13	32906615	32906615	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:32906615C>T	ENST00000544455.1	+	10	1227	c.1000C>T	c.(1000-1002)Cat>Tat	p.H334Y	BRCA2_ENST00000380152.3_Missense_Mutation_p.H334Y	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	334					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAAAATTTTCCATGAAGCAAA	0.294000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			35	75					0	0	0.002836	0	0
OR2T33	391195	broad.mit.edu	37	1	248436229	248436229	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:248436229C>T	ENST00000318021.2	-	1	909	c.888G>A	c.(886-888)aaG>aaA	p.K296K		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCAGGGCTCCCTTCACCTCAC	0.458000													38	63					0	0	0.002222	0	0
MXRA5	25878	broad.mit.edu	37	X	3239265	3239265	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:3239265C>T	ENST00000217939.6	-	5	4615	c.4461G>A	c.(4459-4461)cgG>cgA	p.R1487R		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1487						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCTCCTTCATCCGGGCAGCAG	0.498000													12	54					0	0	0.000978	0	0
SPRY3	10251	broad.mit.edu	37	X	155004375	155004375	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:155004375C>T	ENST00000302805.2	+	2	1273	c.842C>T	c.(841-843)cCc>cTc	p.P281L		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	281					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane						all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCACCCTTCCCCAAGGCCCAG	0.542000													28	42					0	0	0.008361	0	0
FLT1	2321	broad.mit.edu	37	13	29004200	29004200	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr13:29004200G>A	ENST00000282397.4	-	8	1344	c.1093C>T	c.(1093-1095)Ccg>Tcg	p.P365S	FLT1_ENST00000539099.1_Missense_Mutation_p.P365S|FLT1_ENST00000541932.1_Missense_Mutation_p.P365S	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	365	Ig-like C2-type 4.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	ACAACTTCCGGCGAGGGAAAT	0.453000													25	53					0	0	0.006320	0	0
ADAD2	161931	broad.mit.edu	37	16	84230550	84230550	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr16:84230550G>A	ENST00000268624.3	+	11	2061	c.1968G>A	c.(1966-1968)tcG>tcA	p.S656S	RP11-486L19.2_ENST00000536986.1_RNA|RP11-486L19.2_ENST00000569834.1_RNA|ADAD2_ENST00000315906.5_Silent_p.S574S|RP11-486L19.2_ENST00000565643.1_RNA	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	574					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						CTTGGCCCTCGAAGCCACTGG	0.667000													8	8					0	0	0.000978	0	0
GNL3	26354	broad.mit.edu	37	3	52724988	52724988	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:52724988C>T	ENST00000394799.2	+	8	856	c.646C>T	c.(646-648)Cca>Tca	p.P216S	GNL3_ENST00000418458.1_Missense_Mutation_p.P228S	NM_206825.1	NP_996561.1	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)	228					regulation of cell proliferation	nucleolus	GTP binding|protein binding			breast(4)|endometrium(3)|large_intestine(3)|lung(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		GAATGCTGCTCCATTCAGAAG	0.423000													20	29					0	0	0.001523	0	0
DMXL1	1657	broad.mit.edu	37	5	118513857	118513857	+	Silent	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:118513857A>G	ENST00000311085.8	+	28	7133	c.7053A>G	c.(7051-7053)ctA>ctG	p.L2351L	DMXL1_ENST00000539542.1_Silent_p.L2351L	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2351										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CCCATCCTCTAAATGAGAAAA	0.418000													18	55					0	0	0.006122	0	0
GNL3	26354	broad.mit.edu	37	3	52724989	52724989	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:52724989C>T	ENST00000394799.2	+	8	857	c.647C>T	c.(646-648)cCa>cTa	p.P216L	GNL3_ENST00000418458.1_Missense_Mutation_p.P228L	NM_206825.1	NP_996561.1	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)	228					regulation of cell proliferation	nucleolus	GTP binding|protein binding			breast(4)|endometrium(3)|large_intestine(3)|lung(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		AATGCTGCTCCATTCAGAAGT	0.423000													19	31					0	0	0.008871	0	0
SFRP2	6423	broad.mit.edu	37	4	154709489	154709489	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:154709489C>T	ENST00000274063.4	-	1	783	c.499G>A	c.(499-501)Gaa>Aaa	p.E167K		NM_003013.2	NP_003004.1	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2	167					brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	16	all_hematologic(180;0.093)	Renal(120;0.117)				GGCTTACCTTCCTCGGTGGCT	0.652000													17	22					0	0	0.006122	0	0
NEDD4L	23327	broad.mit.edu	37	18	56024452	56024452	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr18:56024452C>T	ENST00000456986.1	+	19	1972	c.1372C>T	c.(1372-1374)Cca>Tca	p.P458S	NEDD4L_ENST00000586263.1_Missense_Mutation_p.P551S|NEDD4L_ENST00000435432.2_Missense_Mutation_p.P438S|NEDD4L_ENST00000431212.2_Missense_Mutation_p.P458S|NEDD4L_ENST00000400345.3_Missense_Mutation_p.P579S|NEDD4L_ENST00000456173.2_Missense_Mutation_p.P438S|NEDD4L_ENST00000382850.4_Missense_Mutation_p.P559S|NEDD4L_ENST00000589054.1_Intron|NEDD4L_ENST00000256830.9_Missense_Mutation_p.P475S|NEDD4L_ENST00000256832.7_Missense_Mutation_p.P438S|NEDD4L_ENST00000356462.6_Missense_Mutation_p.P515S|NEDD4L_ENST00000357895.5_Missense_Mutation_p.P571S	NM_001144964.1	NP_001138436.1	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	579					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			breast(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(11)|ovary(1)|prostate(4)	37						GTGGGAAGACCCAAGACTGCA	0.328000													11	10					0	0	0.008291	0	0
KIF1A	547	broad.mit.edu	37	2	241722495	241722495	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:241722495G>A	ENST00000498729.2	-	9	1076	c.830C>T	c.(829-831)aCc>aTc	p.T277I	KIF1A_ENST00000320389.7_Missense_Mutation_p.T277I	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	277	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CTTGCCCAGGGTGGTCAGCGA	0.657000													13	43					0	0	0.001855	0	0
FBXO21	23014	broad.mit.edu	37	12	117603355	117603355	+	Missense_Mutation	SNP	C	C	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:117603355C>G	ENST00000427718.2	-	9	1335	c.1261G>C	c.(1261-1263)Gac>Cac	p.D421H	FBXO21_ENST00000330622.5_Missense_Mutation_p.D421H	NM_015002.2|NM_033624.2	NP_055817.1|NP_296373.1	O94952	FBX21_HUMAN	F-box protein 21	421					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(4)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|pancreas(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	29	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		TGCACCTGGTCCGGGTACATT	0.493000													19	37					0	0	0.007413	0	0
BCL6	604	broad.mit.edu	37	3	187449569	187449569	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:187449569G>A	ENST00000406870.2	-	4	677	c.311C>T	c.(310-312)gCt>gTt	p.A104V	BCL6_ENST00000232014.4_Missense_Mutation_p.A104V|RP11-211G3.3_ENST00000449623.1_Intron|RP11-211G3.3_ENST00000437407.1_Intron|BCL6_ENST00000450123.2_Missense_Mutation_p.A104V	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	104					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		GGCCATCACAGCCATGATGTT	0.527000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								29	37					0	0	0.002836	0	0
CA14	23632	broad.mit.edu	37	1	150235484	150235484	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:150235484C>T	ENST00000369111.4	+	7	1576	c.606C>T	c.(604-606)ctC>ctT	p.L202L		NM_012113.1	NP_036245.1	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV	202						integral to membrane	carbonate dehydratase activity|metal ion binding			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	18	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGAGCTGCTCCCCAAACAGC	0.522000													23	36					0	0	0.002299	0	0
ASIC5	51802	broad.mit.edu	37	4	156784842	156784842	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:156784842C>T	ENST00000537611.2	-	2	151	c.105G>A	c.(103-105)aaG>aaA	p.K35K	TDO2_ENST00000506181.1_Intron	NM_017419.2	NP_059115.1	Q9NY37	ACCN5_HUMAN	acid-sensing (proton-gated) ion channel family member 5	35						integral to membrane|plasma membrane											GGTCAAACTTCTTTCGCTCAG	0.418000													14	48					0	0	0.003163	0	0
CFTR	1080	broad.mit.edu	37	7	117199600	117199600	+	Missense_Mutation	SNP	C	C	T	rs121909017		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:117199600C>T	ENST00000003084.6	+	11	1607	c.1475C>T	c.(1474-1476)tCt>tTt	p.S492F	CFTR_ENST00000454343.1_Missense_Mutation_p.S431F	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	492	ABC transporter 1.		S -> F (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TCATTCTGTTCTCAGTTTTCC	0.383000									Cystic Fibrosis				30	26					0	0	0.002445	0	0
S100A13	6284	broad.mit.edu	37	1	153591502	153591502	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:153591502G>A	ENST00000368699.1	-	5	669	c.166C>T	c.(166-168)Ctt>Ttt	p.L56F	S100A13_ENST00000339556.4_Missense_Mutation_p.L56F|S100A13_ENST00000491177.1_5'UTR|S100A13_ENST00000440685.2_Missense_Mutation_p.L56F|S100A13_ENST00000392622.1_Missense_Mutation_p.L56F|S100A13_ENST00000392623.1_Missense_Mutation_p.L56F	NM_001024210.1	NP_001019381.1	Q99584	S10AD_HUMAN	S100 calcium binding protein A13	56					interleukin-1 alpha secretion|mast cell degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|extracellular space|nucleus|perinuclear region of cytoplasm	calcium ion binding|copper ion binding|fibroblast growth factor 1 binding|lipid binding|protein homodimerization activity|RAGE receptor binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(4)	7	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	TTCTCATCAAGAGAGCCCACA	0.483000													39	79					0	0	0.008740	0	0
BTBD11	121551	broad.mit.edu	37	12	108013885	108013885	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:108013885G>A	ENST00000280758.5	+	11	3103	c.2575G>A	c.(2575-2577)Gag>Aag	p.E859K	BTBD11_ENST00000357167.4_Missense_Mutation_p.E396K|BTBD11_ENST00000490090.2_Missense_Mutation_p.E859K|BTBD11_ENST00000420571.2_Missense_Mutation_p.E740K	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	859						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GGAATACACGGAGGAGCTCGT	0.532000													18	24					0	0	0.001882	0	0
CLCA4	22802	broad.mit.edu	37	1	87045258	87045258	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:87045258G>A	ENST00000370563.3	+	13	2386	c.2344G>A	c.(2344-2346)Gat>Aat	p.D782N	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	782						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AGATAATTTTGATGTTGGAAA	0.428000													7	35					0	0	0.003080	0	0
SSTR3	6753	broad.mit.edu	37	22	37603295	37603295	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:37603295C>T	ENST00000328544.3	-	2	1081	c.548G>A	c.(547-549)gGa>gAa	p.G183E	SSTR3_ENST00000402501.1_Missense_Mutation_p.G183E	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	183					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						GCGGGGCACTCCCGAGAAGAC	0.726000													5	8					0	0	0.001984	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262587	140262587	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140262587C>T	ENST00000289272.2	+	1	734	c.734C>T	c.(733-735)tCc>tTc	p.S245F	PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.S245F|PCDHA12_ENST00000398631.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTACCAATCCGTTTATAAA	0.458000													5	39					0	0	0.001168	0	0
IGHV4-31	28396	broad.mit.edu	37	14	106805642	106805642	+	RNA	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr14:106805642C>T	ENST00000438142.2	-	0	74																											ACAGGTGTTTCATGTTCTTGC	0.522000													14	55					0	0	0.007413	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979749	12979749	+	Missense_Mutation	SNP	G	G	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:12979749G>T	ENST00000361079.2	+	4	1024	c.941G>T	c.(940-942)tGg>tTg	p.W314L						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CATCTCTCTTGGTGCCCGAGC	0.562000													16	118					1.87028e-06	5.70978e-06	0.001882	1	0
ATP7A	538	broad.mit.edu	37	X	77243950	77243950	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:77243950G>A	ENST00000341514.6	+	3	488	c.333G>A	c.(331-333)aaG>aaA	p.K111K	ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000343533.5_Silent_p.K111K	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	111					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						TGAAGACCAAGGGTGTGACAG	0.438000													58	286					0	0	0.003610	0	0
CT62	196993	broad.mit.edu	37	15	71403676	71403676	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:71403676C>T	ENST00000449977.2	-	4	731	c.225G>A	c.(223-225)aaG>aaA	p.K75K	THSD4_ENST00000355327.3_Intron|CT62_ENST00000566432.1_3'UTR|RP11-673C5.4_ENST00000564862.1_RNA	NM_001102658.1	NP_001096128.1	P0C5K7	CT62_HUMAN	cancer/testis antigen 62	75										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(2)	6						AGAATTTTCTCTTGCCCAGTT	0.522000													12	29					0	0	0.001855	0	0
DNAH9	1770	broad.mit.edu	37	17	11650910	11650910	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:11650910C>T	ENST00000262442.3	+	32	6505	c.6437C>T	c.(6436-6438)tCt>tTt	p.S2146F	DNAH9_ENST00000454412.2_Missense_Mutation_p.S2146F	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2146	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTGCGGCACTCTGTATTTGTG	0.597000													11	18					0	0	0.002450	0	0
CDKAL1	54901	broad.mit.edu	37	6	21201483	21201483	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:21201483G>A	ENST00000274695.4	+	15	1693	c.1526G>A	c.(1525-1527)gGa>gAa	p.G509E	CDKAL1_ENST00000476517.1_3'UTR|CDKAL1_ENST00000378624.4_Missense_Mutation_p.G418E|CDKAL1_ENST00000378610.1_Missense_Mutation_p.G509E	NM_017774.3	NP_060244.2	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein 1-like 1	509					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|stomach(1)	29	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			CTAGCAAAGGGAGAAGTCTCG	0.468000													64	166					0	0	0.003610	0	0
ABCA2	20	broad.mit.edu	37	9	139910781	139910781	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:139910781G>A	ENST00000265662.5	-	21	3213	c.3066C>T	c.(3064-3066)tcC>tcT	p.S1022S	ABCA2_ENST00000371605.3_Silent_p.S1021S|ABCA2_ENST00000341511.6_Silent_p.S1022S			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1021	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGCCCAAGAAGGAGACCACCT	0.597000													6	17					0	0	0.001984	0	0
TSHB	7252	broad.mit.edu	37	1	115576094	115576094	+	Silent	SNP	T	T	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:115576094T>C	ENST00000256592.1	+	2	179	c.111T>C	c.(109-111)gcT>gcC	p.A37A	TSHB_ENST00000369517.1_Silent_p.A37A	NM_000549.3|NM_001277991.1	NP_000540.2|NP_001264920.1	P01222	TSHB_HUMAN	thyroid stimulating hormone, beta	37					anatomical structure morphogenesis|cell-cell signaling|cellular nitrogen compound metabolic process|G-protein coupled receptor protein signaling pathway|hormone biosynthetic process|peptide hormone processing	extracellular region	hormone activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	Lung SC(450;0.211)	all_cancers(81;3.22e-07)|all_epithelial(167;1.4e-06)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		GAGAGTGTGCTTATTGCCTAA	0.413000													30	32					0	0	0.002445	0	0
RAD54L2	23132	broad.mit.edu	37	3	51696606	51696606	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:51696606C>T	ENST00000409535.1	+	22	3699	c.3574C>T	c.(3574-3576)Cgt>Tgt	p.R1192C	RAD54L2_ENST00000296477.3_Missense_Mutation_p.R886C	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	1192						nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CCGGGAATCCCGTCAGAGCTC	0.652000													14	27					0	0	0.001855	0	0
MAPKAP1	79109	broad.mit.edu	37	9	128347848	128347848	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:128347848C>T	ENST00000265960.3	-	5	989	c.657G>A	c.(655-657)cgG>cgA	p.R219R	MAPKAP1_ENST00000373511.2_Silent_p.R219R|MAPKAP1_ENST00000373497.5_Silent_p.R27R|MAPKAP1_ENST00000394060.3_Silent_p.R219R|MAPKAP1_ENST00000373503.3_Silent_p.R27R|MAPKAP1_ENST00000394063.1_Silent_p.R27R|MAPKAP1_ENST00000373498.1_Silent_p.R219R|MAPKAP1_ENST00000350766.3_Silent_p.R219R	NM_001006617.1	NP_001006618.1	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated protein 1	219					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(3)	23						GCTTCGGCTCCCGTCCTTCGC	0.542000													10	38					0	0	0.001368	0	0
TPTE	7179	broad.mit.edu	37	21	10933870	10933870	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr21:10933870G>A	ENST00000298232.7	-	16	1322	c.955C>T	c.(955-957)Cac>Tac	p.H319Y	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.H299Y|TPTE_ENST00000361285.4_Missense_Mutation_p.H337Y	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	337	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCTTTACAGTGAATCGCTACG	0.328000													36	229					0	0	0.004289	0	0
SOX5	6660	broad.mit.edu	37	12	23818467	23818467	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:23818467G>A	ENST00000546136.1	-	6	805	c.803C>T	c.(802-804)cCc>cTc	p.P268L	SOX5_ENST00000451604.2_Missense_Mutation_p.P281L|SOX5_ENST00000545921.1_Missense_Mutation_p.P271L|SOX5_ENST00000309359.1_Missense_Mutation_p.P268L|SOX5_ENST00000381381.2_Missense_Mutation_p.P268L|SOX5_ENST00000537393.1_Missense_Mutation_p.P246L|SOX5_ENST00000541536.1_Missense_Mutation_p.P268L			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	281					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						AGGGAATACGGGAATCATTAA	0.512000													40	47					0	0	0.002852	0	0
RFX6	222546	broad.mit.edu	37	6	117245850	117245850	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:117245850G>A	ENST00000332958.2	+	15	1590	c.1574G>A	c.(1573-1575)cGa>cAa	p.R525Q		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	525					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding	p.R525Q(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						CATTTGATTCGAATGCTTCTC	0.383000													22	16					0	0	0.001882	0	0
GTF3C5	9328	broad.mit.edu	37	9	135927462	135927462	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr9:135927462C>T	ENST00000372097.5	+	5	1107	c.784C>T	c.(784-786)Ccc>Tcc	p.P262S	GTF3C5_ENST00000342018.8_Intron|GTF3C5_ENST00000372095.5_Missense_Mutation_p.P137S|GTF3C5_ENST00000372099.6_Missense_Mutation_p.P253S|GTF3C5_ENST00000372108.5_Missense_Mutation_p.P262S	NM_012087.3	NP_036219.2	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5, 63kDa	262						transcription factor TFIIIC complex	DNA binding|protein binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		TGACATCCGTCCCATCTGGTC	0.562000													15	20					0	0	0.003163	0	0
BTBD9	114781	broad.mit.edu	37	6	38560556	38560556	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:38560556G>A	ENST00000481247.1	-	4	761	c.610C>T	c.(610-612)Cta>Tta	p.L204L	BTBD9_ENST00000408958.1_Silent_p.L136L|BTBD9_ENST00000419706.2_Silent_p.L145L|BTBD9_ENST00000403056.1_Silent_p.L204L|BTBD9_ENST00000314100.6_Silent_p.L136L	NM_001099272.1|NM_052893.1	NP_001092742.1|NP_443125.1	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9	204	BACK.				cell adhesion					breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	12						AATAAGGCTAGGAAAATATCT	0.383000													13	19					0	0	0.001855	0	0
LPP	4026	broad.mit.edu	37	3	188327358	188327358	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:188327358G>A	ENST00000312675.4	+	6	1085	c.839G>A	c.(838-840)gGa>gAa	p.G280E	LPP_ENST00000543006.1_Missense_Mutation_p.G280E|LPP_ENST00000471917.1_3'UTR|LPP_ENST00000448637.1_Missense_Mutation_p.G280E	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	280	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		CCACCACCAGGACTTCAGCCG	0.577000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								6	62					0	0	0.001168	0	0
LGSN	51557	broad.mit.edu	37	6	63990433	63990433	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:63990433C>T	ENST00000370658.5	-	5	635	c.602G>A	c.(601-603)gGa>gAa	p.G201E	LGSN_ENST00000370657.4_Silent_p.G341G	NM_001143940.1|NM_016571.2	NP_001137412.1|NP_057655.2	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	0					glutamine biosynthetic process		glutamate-ammonia ligase activity	p.G341G(1)		NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	ACCATTTTTTCCCAGTGATCG	0.488000													22	18					0	0	0.002299	0	0
DHX37	57647	broad.mit.edu	37	12	125438543	125438543	+	Splice_Site	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr12:125438543C>T	ENST00000308736.2	-	20	2677		c.e20-1		DHX37_ENST00000544745.1_Splice_Site	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37								ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CCCACGGCGCCTGGGGAACGA	0.657000													7	7					0	0	0.004482	0	0
CD2	914	broad.mit.edu	37	1	117303207	117303207	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:117303207G>A	ENST00000369478.3	+	3	674	c.566G>A	c.(565-567)gGg>gAg	p.G189E		NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	189	Ig-like C2-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	TGCACAGCAGGGAACAAAGTC	0.512000													11	27					0	0	0.001368	0	0
CCDC33	80125	broad.mit.edu	37	15	74623062	74623062	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr15:74623062G>A	ENST00000321288.5	+	15	2124	c.2124G>A	c.(2122-2124)agG>agA	p.R708R	CCDC33_ENST00000268082.4_Silent_p.R98R|CCDC33_ENST00000558821.1_Silent_p.R98R|CCDC33_ENST00000398814.3_Silent_p.R505R			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	708							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						TGAGGGACAGGGTGCAGCATT	0.572000													9	30					0	0	0.006214	0	0
PREB	10113	broad.mit.edu	37	2	27355501	27355501	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:27355501G>A	ENST00000260643.2	-	5	975	c.722C>T	c.(721-723)tCc>tTc	p.S241F	PREB_ENST00000406567.3_Missense_Mutation_p.S241F	NM_013388.4	NP_037520.1	Q9HCU5	PREB_HUMAN	prolactin regulatory element binding	241					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nucleus	DNA binding|guanyl-nucleotide exchange factor activity|protein binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGTGTGCTGGAAAAGGTGGG	0.567000													10	28					0	0	0.008291	0	0
F13A1	2162	broad.mit.edu	37	6	6145907	6145907	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:6145907A>G	ENST00000264870.3	-	15	2409	c.2144T>C	c.(2143-2145)cTg>cCg	p.L715P		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	715					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CACATGTCTCAGGGAGTCACT	0.557000													20	55					0	0	0.001523	0	0
XK	7504	broad.mit.edu	37	X	37545385	37545385	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:37545385C>T	ENST00000378616.3	+	1	374	c.171C>T	c.(169-171)ttC>ttT	p.F57F	TM4SF2_ENST00000465127.1_Intron	NM_021083.2	NP_066569.1	P51811	XK_HUMAN	X-linked Kx blood group (McLeod syndrome)	57					amino acid transport	integral to membrane	protein binding|transporter activity			breast(1)|endometrium(4)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	15		all_lung(315;0.175)				CGCTTCTCTTCGTACACCGCG	0.657000													11	12					0	0	0.000978	0	0
OR4C15	81309	broad.mit.edu	37	11	55322530	55322530	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:55322530C>T	ENST00000314644.2	+	1	748	c.748C>T	c.(748-750)Ctc>Ttc	p.L250F		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						CATCTTTGGCCTCATGGTGGT	0.458000										HNSCC(20;0.049)			23	17					0	0	0.001882	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166314	140166314	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:140166314C>T	ENST00000504120.2	+	1	439	c.439C>T	c.(439-441)Ctc>Ttc	p.L147F	PCDHA1_ENST00000378133.3_Missense_Mutation_p.L147F|PCDHA1_ENST00000394633.3_Missense_Mutation_p.L147F	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAATCTAGACTCCTGAATTC	0.448000													14	65					0	0	0.004990	0	0
SH3TC2	79628	broad.mit.edu	37	5	148388436	148388436	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:148388436G>A	ENST00000538184.1	-	11	2985	c.2097C>T	c.(2095-2097)gcC>gcT	p.A699A	SH3TC2_ENST00000515425.1_Silent_p.A1152A|SH3TC2_ENST00000512049.1_Silent_p.A1145A			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1152							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGCCTGGCGGCCAGGGTGG	0.512000													25	69					0	0	0.003954	0	0
NCAPH2	29781	broad.mit.edu	37	22	50961485	50961485	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr22:50961485C>T	ENST00000395701.3	+	19	1661	c.1567C>T	c.(1567-1569)Cag>Tag	p.Q523*	NCAPH2_ENST00000420993.2_Nonsense_Mutation_p.Q523*|NCAPH2_ENST00000299821.11_Nonsense_Mutation_p.Q524*			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2	523					chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CTATGGGGACCAGCTGGTCTC	0.642000													7	17					0	0	0.001984	0	0
HIVEP1	3096	broad.mit.edu	37	6	12161705	12161705	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:12161705G>A	ENST00000379388.2	+	8	6853	c.6521G>A	c.(6520-6522)gGa>gAa	p.G2174E	HIVEP1_ENST00000541134.1_Missense_Mutation_p.G39E	NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	2174					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GAGCGATCTGGATATGATCTT	0.408000													51	47					0	0	0.003610	0	0
OR5D18	219438	broad.mit.edu	37	11	55587908	55587908	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:55587908C>T	ENST00000333976.4	+	1	823	c.803C>T	c.(802-804)tCc>tTc	p.S268F		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				TCCAAAAACTCCAGGCACACA	0.507000													18	27					0	0	0.007413	0	0
MAGEA5	4104	broad.mit.edu	37	X	151283696	151283696	+	RNA	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:151283696C>T	ENST00000509345.2	-	0	640																											GAGTGCTGCTCGGAACACAGA	0.512000													37	62					0	0	0.005524	0	0
CXorf57	55086	broad.mit.edu	37	X	105881014	105881014	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:105881014A>G	ENST00000372548.4	+	8	1542	c.1433A>G	c.(1432-1434)tAt>tGt	p.Y478C	CXorf57_ENST00000372544.2_Missense_Mutation_p.Y478C	NM_018015.5	NP_060485.4	Q6NSI4	CX057_HUMAN	chromosome X open reading frame 57	478										NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	31						CCGTATACGTATGATGCCAAG	0.378000													11	39					0	0	0.001855	0	0
SCAND3	114821	broad.mit.edu	37	6	28542960	28542960	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:28542960G>A	ENST00000452236.2	-	3	2139	c.1522C>T	c.(1522-1524)Cag>Tag	p.Q508*		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	508	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TGATAGGGCTGATTTTGGGAC	0.423000													33	68					0	0	0.002836	0	0
NSUN7	79730	broad.mit.edu	37	4	40796465	40796465	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr4:40796465G>A	ENST00000381782.2	+	9	1749	c.1254G>A	c.(1252-1254)caG>caA	p.Q418Q	NSUN7_ENST00000316607.5_Silent_p.Q418Q	NM_024677.4	NP_078953.3			NOP2/Sun domain family, member 7											NS(1)|autonomic_ganglia(1)|cervix(1)|large_intestine(1)|lung(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						CTCAACAGCAGTATGAACAGC	0.343000													9	10					0	0	0.008291	0	0
PUM1	9698	broad.mit.edu	37	1	31501645	31501645	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:31501645C>T	ENST00000373747.3	-	3	529	c.430G>A	c.(430-432)Gag>Aag	p.E144K	PUM1_ENST00000424085.2_Missense_Mutation_p.E144K|PUM1_ENST00000257075.5_Missense_Mutation_p.E144K|PUM1_ENST00000426105.2_Missense_Mutation_p.E144K|PUM1_ENST00000440538.2_Missense_Mutation_p.E144K|PUM1_ENST00000423018.2_Missense_Mutation_p.E144K|PUM1_ENST00000373742.2_Missense_Mutation_p.E180K|PUM1_ENST00000373741.4_Missense_Mutation_p.E180K	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	144					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TCACTTACCTCTCCCATCGCT	0.408000													27	70					0	0	0.002445	0	0
TNIP1	10318	broad.mit.edu	37	5	150411944	150411944	+	Splice_Site	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr5:150411944G>A	ENST00000389378.2	-	17	2368	c.1779_splice	c.e17-1	p.P594_splice	TNIP1_ENST00000315050.7_Splice_Site_p.P594_splice|TNIP1_ENST00000518977.1_Splice_Site_p.P594_splice|TNIP1_ENST00000524280.1_Intron|TNIP1_ENST00000520931.1_Splice_Site_p.P541_splice|TNIP1_ENST00000522226.1_Splice_Site_p.P594_splice|TNIP1_ENST00000523338.1_Splice_Site_p.P594_splice|TNIP1_ENST00000523200.1_Splice_Site_p.P530_splice|TNIP1_ENST00000521423.1_5'UTR|TNIP1_ENST00000521591.1_Splice_Site_p.P594_splice	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	594	Pro-rich.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGTATTCCGGCTGCGACAAA	0.463000													13	8					0	0	0.001855	0	0
LAMB4	22798	broad.mit.edu	37	7	107756451	107756451	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr7:107756451C>T	ENST00000388781.3	-	3	273	c.190G>A	c.(190-192)Gag>Aag	p.E64K	LAMB4_ENST00000414450.2_Missense_Mutation_p.E64K|LAMB4_ENST00000205386.4_Missense_Mutation_p.E64K|LAMB4_ENST00000388780.3_Missense_Mutation_p.E64K	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	64	Laminin N-terminal.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CAACCCACCTCCAGGTAACTG	0.478000													26	23					0	0	0.003954	0	0
DSP	1832	broad.mit.edu	37	6	7576533	7576533	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr6:7576533G>A	ENST00000379802.3	+	19	2978	c.2637G>A	c.(2635-2637)tgG>tgA	p.W879*	DSP_ENST00000418664.2_Nonsense_Mutation_p.W879*	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	879	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CCAGGTTATGGGACCTGGAGA	0.373000													17	39					0	0	0.007413	0	0
PMEPA1	56937	broad.mit.edu	37	20	56227601	56227601	+	Silent	SNP	G	G	A			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr20:56227601G>A	ENST00000341744.3	-	4	691	c.372C>T	c.(370-372)ttC>ttT	p.F124F	PMEPA1_ENST00000395816.3_Silent_p.F74F|PMEPA1_ENST00000395814.1_Silent_p.F74F|PMEPA1_ENST00000265626.4_Silent_p.F74F|PMEPA1_ENST00000347215.4_Silent_p.F89F	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	124					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						CCCGCTGGGCGAAGGGCGGCA	0.706000													6	8					0	0	0.001168	0	0
SPEG	10290	broad.mit.edu	37	2	220309693	220309693	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr2:220309693C>T	ENST00000312358.7	+	3	757	c.625C>T	c.(625-627)Ccg>Tcg	p.P209S	SPEG_ENST00000396695.2_5'UTR|SPEG_ENST00000396698.1_Missense_Mutation_p.P105S	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	209					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCGCCGCCTCCCGGGCAGCCC	0.716000													6	7					0	0	0.001168	0	0
KIAA1429	25962	broad.mit.edu	37	8	95538606	95538606	+	Silent	SNP	C	C	T			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:95538606C>T	ENST00000297591.5	-	8	1941	c.1866G>A	c.(1864-1866)ggG>ggA	p.G622G	KIAA1429_ENST00000437199.1_Silent_p.G622G|KIAA1429_ENST00000421249.2_Silent_p.G622G	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	622					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTTCTATTTCCCCTTCACTTA	0.383000													14	47					0	0	0.002450	0	0
ADCK3	56997	broad.mit.edu	37	1	227153415	227153431	+	Frame_Shift_Del	DEL	TTGGCCGGCTGGCCAAC	TTGGCCGGCTGGCCAAC	-	rs119468005		TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr1:227153415_227153431delTTGGCCGGCTGGCCAAC	ENST00000366779.1	+	9	3403_3419	c.632_648delTTGGCCGGCTGGCCAAC	c.(631-648)afs	p.IGRLAN211fs	ADCK3_ENST00000478406.1_Intron|ADCK3_ENST00000366777.3_Frame_Shift_Del_p.IGRLAN211fs|ADCK3_ENST00000458507.2_Intron|ADCK3_ENST00000366776.1_Frame_Shift_Del_p.IGRLAN136fs|ADCK3_ENST00000433743.2_5'UTR|ADCK3_ENST00000366778.1_Frame_Shift_Del_p.IGRLAN159fs|ADCK3_ENST00000366775.1_Frame_Shift_Del_p.IGRLAN56fs			Q8NI60	ADCK3_HUMAN	aarF domain containing kinase 3	211					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(2)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	9						GTGACGAGGATTGGCCGGCTGGCCAACTTCGGAGGTA	0.645													8	24	---	---	---	---					
RBM5	10181	broad.mit.edu	37	3	50151482	50151483	+	Frame_Shift_Ins	INS	-	-	G			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:50151482_50151483insG	ENST00000347869.3	+	19	1892_1893	c.1717_1718insG	c.(1717-1719)gagfs	p.E573fs		NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	573	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGAAGAAGAAAGGAGAGAATCT	0.426													10	52	---	---	---	---					
MUC13	56667	broad.mit.edu	37	3	124646549	124646552	+	Frame_Shift_Del	DEL	AATG	AATG	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr3:124646549_124646552delAATG	ENST00000311075.3	-	2	376_379	c.338_341delCATT	c.(337-342)tafs	p.SL113fs		NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	113	Thr-rich.					extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						AGAGGTAGCTAATGAATTTACATT	0.412													47	119	---	---	---	---					
EIF3H	8667	broad.mit.edu	37	8	117658804	117658824	+	In_Frame_Del	DEL	CTGGCGCTGCATATTCTCCTG	CTGGCGCTGCATATTCTCCTG	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr8:117658804_117658824delCTGGCGCTGCATATTCTCCTG	ENST00000521861.1	-	7	870_890	c.847_867delCAGGAGAATATGCAGCGCCAG	c.(847-867)del	p.QENMQRQ283del	EIF3H_ENST00000276682.4_In_Frame_Del_p.QENMQRQ297del	NM_003756.2	NP_003747.1	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3, subunit H	283					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			large_intestine(2)|lung(10)|skin(1)	13	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					CTCCTCGGCTCTGGCGCTGCATATTCTCCTGCTGGCGACGC	0.520													14	126	---	---	---	---					
PTPN5	84867	broad.mit.edu	37	11	18762237	18762237	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:18762237delC	ENST00000396170.1	-	8	1996	c.732delG	c.(730-732)gafs	p.E244fs	PTPN5_ENST00000358540.2_Frame_Shift_Del_p.E276fs|PTPN5_ENST00000396171.4_Frame_Shift_Del_p.E276fs|PTPN5_ENST00000477854.1_Frame_Shift_Del_p.E80fs|PTPN5_ENST00000396168.1_Frame_Shift_Del_p.E252fs|PTPN5_ENST00000396167.2_Frame_Shift_Del_p.E244fs	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	276						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						TGAGCAGGTACTCGCGGGCGG	0.597													19	18	---	---	---	---					
SLC22A6	9356	broad.mit.edu	37	11	62744845	62744845	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:62744845delC	ENST00000377871.3	-	9	1642	c.1376delG	c.(1375-1377)gafs	p.G459fs	SLC22A6_ENST00000421062.2_Intron|SLC22A6_ENST00000458333.2_Intron|SLC22A6_ENST00000360421.4_Frame_Shift_Del_p.G459fs	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	459					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GCTGCCCATTCCCATGCCTGT	0.607													5	5	---	---	---	---					
USP28	57646	broad.mit.edu	37	11	113673923	113673924	+	Frame_Shift_Ins	INS	-	-	C			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr11:113673923_113673924insC	ENST00000003302.4	-	23	2886_2887	c.2818_2819insG	c.(2818-2820)caafs	p.Q940fs	USP28_ENST00000260188.5_Frame_Shift_Ins_p.Q908fs|USP28_ENST00000545540.1_Frame_Shift_Ins_p.Q783fs|USP28_ENST00000544967.1_Frame_Shift_Ins_p.Q616fs	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	940					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		GGATTCTTTGACCCCCCGGCGG	0.455													17	41	---	---	---	---					
ZNF287	57336	broad.mit.edu	37	17	16455883	16455885	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chr17:16455883_16455885delGAA	ENST00000395824.1	-	6	2188_2190	c.1571_1573delTTC	c.(1570-1575)cag>c	p.LQ524del	ZNF287_ENST00000395825.3_In_Frame_Del_p.LQ524del			Q9HBT7	ZN287_HUMAN	zinc finger protein 287	517					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|prostate(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TTTTGATGCTGAAGAAGGTGTGT	0.350													14	59	---	---	---	---					
TAF1	6872	broad.mit.edu	37	X	70612480	70612480	+	Frame_Shift_Del	DEL	T	T	-			TCGA-EE-A2MP-06A-11D-A197-08	TCGA-EE-A2MP-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6526a259-00e0-4ab5-b0d3-dec541791b81	c288ef56-e293-401a-bfac-ed4d76b8724b	g.chrX:70612480delT	ENST00000449580.1	+	19	2891	c.2840delT	c.(2839-2841)cgfs	p.L948fs	TAF1_ENST00000423759.1_Frame_Shift_Del_p.L969fs|TAF1_ENST00000276072.3_Frame_Shift_Del_p.L969fs|TAF1_ENST00000373790.4_Frame_Shift_Del_p.L948fs			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	948					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				GGCAAGTGTCTGCTAGAGGTG	0.507													45	46	---	---	---	---					
