Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CD22	933	broad.mit.edu	37	19	35827206	35827206	+	Missense_Mutation	SNP	A	A	T			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr19:35827206A>T	ENST00000085219.5	+	4	746	c.680A>T	c.(679-681)aAg>aTg	p.K227M	CD22_ENST00000536635.2_Missense_Mutation_p.K227M|CD22_ENST00000270311.6_Missense_Mutation_p.K107M|CD22_ENST00000594250.1_Missense_Mutation_p.K227M|CD22_ENST00000341773.6_Missense_Mutation_p.K227M|CD22_ENST00000544992.2_Missense_Mutation_p.K227M|CD22_ENST00000419549.2_Missense_Mutation_p.K55M	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	227	Ig-like C2-type 1.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GCAGATGGGAAGTTCCTCTCC	0.582000													37	51					0	0	0.048971	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	NBPF10_ENST00000369338.1_Silent_p.L113L|NBPF10_ENST00000369339.2_Silent_p.L113L|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													3	66					0	0	0.009096	0	0
ZFPM2	23414	broad.mit.edu	37	8	106801107	106801107	+	Missense_Mutation	SNP	C	C	A			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr8:106801107C>A	ENST00000407775.2	+	6	944	c.694C>A	c.(694-696)Cag>Aag	p.Q232K	RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|ZFPM2_ENST00000520492.1_Missense_Mutation_p.Q100K|ZFPM2_ENST00000378472.4_5'UTR|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.Q100K	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	232					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GCTGCTTCCTCAGCAAGCTGC	0.498000													108	22					1.04646e-50	1.42699e-50	0.048971	1	0
SCN2A	6326	broad.mit.edu	37	2	166246020	166246020	+	Missense_Mutation	SNP	C	C	T			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr2:166246020C>T	ENST00000357398.3	+	27	5994	c.5704C>T	c.(5704-5706)Cgc>Tgc	p.R1902C	SCN2A_ENST00000375437.2_Missense_Mutation_p.R1902C|SCN2A_ENST00000283256.6_Missense_Mutation_p.R1902C|SCN2A_ENST00000375427.2_Missense_Mutation_p.R1902C			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1902			R -> T (associated with autism).		myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CACGTTGAAACGCAAACAAGA	0.433000													15	34					0	0	0.028581	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140768251	140768251	+	Missense_Mutation	SNP	C	C	T			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr5:140768251C>T	ENST00000519479.1	+	1	800	c.800C>T	c.(799-801)aCg>aTg	p.T267M	PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGACTGCCACGGACCAGGAT	0.498000													85	121					0	0	0.048971	0	0
FBLN1	2192	broad.mit.edu	37	22	45914606	45914606	+	Missense_Mutation	SNP	C	C	T			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr22:45914606C>T	ENST00000348697.2	+	2	271	c.124C>T	c.(124-126)Cgg>Tgg	p.R42W	FBLN1_ENST00000442170.2_Missense_Mutation_p.R42W|FBLN1_ENST00000327858.6_Missense_Mutation_p.R42W|FBLN1_ENST00000402984.3_Missense_Mutation_p.R42W|FBLN1_ENST00000340923.5_Missense_Mutation_p.R42W|FBLN1_ENST00000262722.7_Missense_Mutation_p.R42W			P23142	FBLN1_HUMAN	fibulin 1	42	Anaphylatoxin-like 1.			HR -> SH (in Ref. 8; AA sequence).	interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GGACGGACACCGGATGGCCAC	0.582000													20	20					0	0	0.083992	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													5	154					0	0	0.014758	0	0
SALL3	27164	broad.mit.edu	37	18	76755190	76755190	+	Missense_Mutation	SNP	G	G	A			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr18:76755190G>A	ENST00000536229.3	+	2	3293	c.2584G>A	c.(2584-2586)Ggt>Agt	p.G862S	SALL3_ENST00000537592.2_Missense_Mutation_p.G1067S|SALL3_ENST00000575389.2_Missense_Mutation_p.G995S			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1067					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGAAGTGAACGGTCACGGCAA	0.652000													34	51					0	0	0.064281	0	0
ZNF681	148213	broad.mit.edu	37	19	23926839	23926839	+	Missense_Mutation	SNP	A	A	G			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr19:23926839A>G	ENST00000402377.3	-	4	1654	c.1513T>C	c.(1513-1515)Tcc>Ccc	p.S505P	ZNF681_ENST00000395385.3_Missense_Mutation_p.S436P	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	505					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CATTTGTAGGATTTCTCTCCA	0.373000													3	105					0	0	0.009096	0	0
NPHP1	4867	broad.mit.edu	37	2	110905497	110905497	+	Missense_Mutation	SNP	C	C	T			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr2:110905497C>T	ENST00000316534.4	-	13	1506	c.1433G>A	c.(1432-1434)cGc>cAc	p.R478H	NPHP1_ENST00000417665.1_Missense_Mutation_p.R421H|NPHP1_ENST00000393272.3_Missense_Mutation_p.R477H|NPHP1_ENST00000355301.4_Missense_Mutation_p.R359H|NPHP1_ENST00000445609.2_Missense_Mutation_p.R422H			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	477					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						ACATACATTGCGAATATAAGA	0.343000													35	53					0	0	0.069456	0	0
CDC7	8317	broad.mit.edu	37	1	91967356	91967356	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr1:91967356T>A	ENST00000428239.1	+	2	342	c.83T>A	c.(82-84)tTa>tAa	p.L28*	CDC7_ENST00000497611.1_3'UTR|CDC7_ENST00000430031.2_Nonsense_Mutation_p.L28*|CDC7_ENST00000234626.6_Nonsense_Mutation_p.L28*	NM_001134420.1	NP_001127892.1	O00311	CDC7_HUMAN	cell division cycle 7	28					cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|stomach(2)	23		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		GAAGGCTCTTTAAAAAAAAAC	0.403000													4	120					0	0	0.009096	0	0
VASN	114990	broad.mit.edu	37	16	4431310	4431310	+	Silent	SNP	C	C	T			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr16:4431310C>T	ENST00000304735.3	+	2	587	c.432C>T	c.(430-432)ttC>ttT	p.F144F	CORO7_ENST00000423908.2_Intron|CORO7_ENST00000251166.4_Intron|CORO7_ENST00000574025.1_Intron|CORO7_ENST00000539968.1_Intron|CORO7_ENST00000537233.2_Intron|CORO7-PAM16_ENST00000572467.1_Intron	NM_138440.2	NP_612449.2	Q6EMK4	VASN_HUMAN	vasorin	144				Missing (in Ref. 2; AAQ88665).		extracellular region|integral to membrane				breast(1)|lung(3)|prostate(1)|skin(1)	6						CTGGTGCCTTCGACACGCTCG	0.677000													15	21					0	0	0.033300	0	0
CLCN3	1182	broad.mit.edu	37	4	170618538	170618538	+	Missense_Mutation	SNP	T	T	C			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr4:170618538T>C	ENST00000513761.1	+	9	1775	c.1216T>C	c.(1216-1218)Ttt>Ctt	p.F406L	CLCN3_ENST00000360642.3_Missense_Mutation_p.F379L|CLCN3_ENST00000347613.4_Missense_Mutation_p.F406L|CLCN3_ENST00000504131.2_Missense_Mutation_p.F389L	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	406					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		TTGGGGAGCCTTTTTCATTAG	0.438000													3	165					0	0	0.004672	0	0
PCNT	5116	broad.mit.edu	37	21	47754527	47754527	+	Missense_Mutation	SNP	A	A	G			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr21:47754527A>G	ENST00000359568.5	+	3	591	c.484A>G	c.(484-486)Agt>Ggt	p.S162G	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	162					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GTTCACAGTCAGTGACCACCC	0.552000													4	180					0	0	0.014758	0	0
DSCAM	1826	broad.mit.edu	37	21	41648146	41648146	+	Missense_Mutation	SNP	A	A	G			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr21:41648146A>G	ENST00000400454.1	-	11	2711	c.2234T>C	c.(2233-2235)gTt>gCt	p.V745A		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	745	Ig-like C2-type 8.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ATTGCTGAGAACTTGGATTCG	0.512000													31	41					0	0	0.050027	0	0
LOC220729	220729	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	A	G	rs144273946	by1000genomes	TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr3:197348674A>G	ENST00000418868.1	-	0	585					NR_003266.2																						GGCTCTGTCCACCAAATGCAC	0.478000													3	156					0	0	0.004672	0	0
ADIPOR2	79602	broad.mit.edu	37	12	1890190	1890190	+	Missense_Mutation	SNP	A	A	G			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr12:1890190A>G	ENST00000357103.4	+	6	1037	c.786A>G	c.(784-786)atA>atG	p.I262M		NM_024551.2	NP_078827.2	Q86V24	ADR2_HUMAN	adiponectin receptor 2	262					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity			endometrium(1)|large_intestine(3)|lung(7)|stomach(1)	12	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)			CAGCCATTATAGTCTCCCAGT	0.443000													3	150					0	0	0.004672	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000392221.1_Silent_p.P45P|EEF1B2_ENST00000236957.5_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													5	157					0	0	0.014758	0	0
HRCT1	646962	broad.mit.edu	37	9	35906559	35906559	+	Missense_Mutation	SNP	A	A	C			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr9:35906559A>C	ENST00000354323.2	+	1	371	c.275A>C	c.(274-276)cAc>cCc	p.H92P		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	92	His-rich.					integral to membrane		p.H92P(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						caccaccaccacccccgccac	0.682000													6	16					0	0	0.038395	0	0
KIAA1210	57481	broad.mit.edu	37	X	118221921	118221921	+	Missense_Mutation	SNP	G	G	C			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chrX:118221921G>C	ENST00000402510.2	-	11	3271	c.3272C>G	c.(3271-3273)aCc>aGc	p.T1091S		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	1091										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						AAATTTAGGGGTCACCCATGG	0.493000													118	160					0	0	0.048971	0	0
SEMG1	6406	broad.mit.edu	37	20	43837052	43837052	+	Missense_Mutation	SNP	C	C	A			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr20:43837052C>A	ENST00000372781.3	+	2	1171	c.1114C>A	c.(1114-1116)Cgc>Agc	p.R372S	SEMG1_ENST00000244069.6_Missense_Mutation_p.R312S	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				TGTATCCCAACGCAGTATTTA	0.418000													3	72					0.004672	0.00600686	0.004672	1	0
MYH11	4629	broad.mit.edu	37	16	15826509	15826509	+	Missense_Mutation	SNP	C	C	T			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr16:15826509C>T	ENST00000338282.6	-	27	3669	c.3563G>A	c.(3562-3564)cGg>cAg	p.R1188Q	MYH11_ENST00000396324.3_Missense_Mutation_p.R1195Q|AF001548.5_ENST00000574212.1_RNA|MYH11_ENST00000576790.1_Missense_Mutation_p.R1188Q|MYH11_ENST00000452625.2_Missense_Mutation_p.R1195Q|MYH11_ENST00000300036.5_Missense_Mutation_p.R1188Q	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1188					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CTCATGGGACCGCGTCTCTTC	0.572000			T	CBFB	AML								68	96					0	0	0.048971	0	0
PRX	57716	broad.mit.edu	37	19	40899883	40899883	+	Missense_Mutation	SNP	G	G	A			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr19:40899883G>A	ENST00000324001.7	-	7	4646	c.4376C>T	c.(4375-4377)gCg>gTg	p.A1459V	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	1459					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCAGACAGCCGCAGCCTGAGC	0.617000													4	127					0	0	0.021553	0	0
TREX2	11219	broad.mit.edu	37	X	152710664	152710664	+	Silent	SNP	G	G	A			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chrX:152710664G>A	ENST00000330912.2	-	13	1775	c.225C>T	c.(223-225)agC>agT	p.S75S	TREX2_ENST00000370232.1_Silent_p.S118S|TREX2_ENST00000334497.2_Silent_p.S118S|TREX2_ENST00000414588.1_Silent_p.S117S|TREX2_ENST00000393862.2_Silent_p.S75S|TREX2_ENST00000402951.1_Silent_p.S118S|TREX2_ENST00000338525.2_Silent_p.S75S|TREX2_ENST00000370231.2_Silent_p.S75S			Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	118					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(2)	11	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGGTGATCTCGCTGGCCTTGG	0.682000								Editing and processing nucleases					3	53					0	0	0.009096	0	0
EYA1	2138	broad.mit.edu	37	8	72233985	72233985	+	Silent	SNP	G	G	A			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr8:72233985G>A	ENST00000340726.3	-	6	1041	c.402C>T	c.(400-402)taC>taT	p.Y134Y	EYA1_ENST00000388741.2_Silent_p.Y100Y|EYA1_ENST00000388743.2_Silent_p.Y133Y|EYA1_ENST00000419131.1_Silent_p.Y134Y|EYA1_ENST00000388740.3_Silent_p.Y101Y|EYA1_ENST00000303824.7_Silent_p.Y133Y|EYA1_ENST00000388742.4_Silent_p.Y134Y	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	134					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			AGGAAATGCCGTACGGCTGTC	0.483000													4	166					0	0	0.014758	0	0
SEPT6	23157	broad.mit.edu	37	X	118783980	118783980	+	Missense_Mutation	SNP	C	C	T			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chrX:118783980C>T	ENST00000394610.1	-	5	874	c.610G>A	c.(610-612)Gag>Aag	p.E204K	SEPT6_ENST00000394616.4_Missense_Mutation_p.E146K|SEPT6_ENST00000354416.3_Missense_Mutation_p.E204K|SEPT6_ENST00000394617.2_Missense_Mutation_p.E234K|SEPT6_ENST00000343984.5_Missense_Mutation_p.E204K|SEPT6_ENST00000360156.7_Missense_Mutation_p.E204K|SEPT6_ENST00000354228.4_Missense_Mutation_p.E204K|SEPT6_ENST00000489216.1_Missense_Mutation_p.E204K	NM_145799.3	NP_665798.1	Q14141	SEPT6_HUMAN	septin 6	204					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(3)	17						CTGACAAGCTCGCTGGTGATT	0.473000			T	MLL	AML								108	161					0	0	0.048971	0	0
ZNF827	152485	broad.mit.edu	37	4	146686225	146686225	+	Missense_Mutation	SNP	A	A	C			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr4:146686225A>C	ENST00000508784.1	-	13	3372	c.3145T>G	c.(3145-3147)Tgt>Ggt	p.C1049G	ZNF827_ENST00000513320.1_Missense_Mutation_p.C699G|ZNF827_ENST00000379448.4_Missense_Mutation_p.C1049G			Q17R98	ZN827_HUMAN	zinc finger protein 827	1049					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					CACACATCACACTCAAACATC	0.493000													60	109					0	0	0.048971	0	0
DAPP1	27071	broad.mit.edu	37	4	100774447	100774447	+	Missense_Mutation	SNP	T	T	C			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr4:100774447T>C	ENST00000296414.7	+	4	512	c.431T>C	c.(430-432)gTt>gCt	p.V144A	DAPP1_ENST00000512369.1_Missense_Mutation_p.V144A			Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and 3-phosphoinositides	144					signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity			endometrium(1)|kidney(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		TCTGTCCGGGTTCACACAGCA	0.448000													9	23					0	0	0.058154	0	0
ARFGAP3	26286	broad.mit.edu	37	22	43204776	43204776	+	Silent	SNP	A	A	C			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr22:43204776A>C	ENST00000263245.5	-	13	1536	c.1317T>G	c.(1315-1317)gcT>gcG	p.A439A	ARFGAP3_ENST00000437119.2_Silent_p.A395A|ARFGAP3_ENST00000429508.2_Silent_p.A367A	NM_001142293.1|NM_014570.4	NP_001135765.1|NP_055385.3	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating protein 3	439					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	11						CCCTTACATCAGCCTGGGATT	0.488000													61	111					0	0	0.048971	0	0
RPTN	126638	broad.mit.edu	37	1	152127845	152127848	+	Frame_Shift_Del	DEL	TGTC	TGTC	-			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr1:152127845_152127848delTGTC	ENST00000316073.3	-	3	1791_1794	c.1727_1730delGACA	c.(1726-1731)aafs	p.RQ576fs		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	576	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						ACTCTGGCCTTGTCTGTCTGTCTG	0.466													8	1039	---	---	---	---					
NKTR	4820	broad.mit.edu	37	3	42679035	42679036	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr3:42679035_42679036insC	ENST00000232978.8	+	13	2027_2028	c.1839_1840insC	c.(1837-1842)agccccfs	p.SP613fs	RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	613					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TGAGTGACAGTCCCCCCCCTTC	0.421													7	375	---	---	---	---					
COL12A1	1303	broad.mit.edu	37	6	75899298	75899298	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr6:75899298delT	ENST00000322507.8	-	6	937	c.628delA	c.(628-630)ttfs	p.I210fs	COL12A1_ENST00000483888.2_Frame_Shift_Del_p.I210fs|COL12A1_ENST00000416123.2_Frame_Shift_Del_p.I210fs|COL12A1_ENST00000345356.6_Intron	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	210	VWFA 1.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TTATATGGAATTTTTTTTATT	0.323													7	176	---	---	---	---					
ZNF704	619279	broad.mit.edu	37	8	81733778	81733778	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr8:81733778delT	ENST00000327835.3	-	2	283	c.52delA	c.(52-54)tgfs	p.M18fs		NM_001033723.2	NP_001028895.1	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	18						intracellular	zinc ion binding			lung(9)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			TGATGAGACATTTTTTTACCA	0.423													9	1586	---	---	---	---					
UBR5	51366	broad.mit.edu	37	8	103289349	103289349	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr8:103289349delT	ENST00000520539.1	-	45	6966	c.6360delA	c.(6358-6360)aafs	p.K2120fs	UBR5_ENST00000220959.4_Frame_Shift_Del_p.K2120fs|UBR5_ENST00000521922.1_Frame_Shift_Del_p.K2114fs	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	2120					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding	p.E2121fs*28(2)		NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTTCCCCTTCTTTTTTTTGCC	0.378													10	614	---	---	---	---					
DUSP8	1850	broad.mit.edu	37	11	1586978	1586979	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr11:1586978_1586979insC	ENST00000397374.3	-	2	205_206	c.78_79insG	c.(76-81)ggcgctfs	p.A27fs	DUSP8_ENST00000331588.4_Frame_Shift_Ins_p.A27fs	NM_004420.2	NP_004411.2	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	27	Rhodanese.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(1)|lung(2)|prostate(1)|urinary_tract(1)	5		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		ATGACCAGCGGCCCCCCAGGCC	0.663													7	358	---	---	---	---					
LOC100506125	100506125	broad.mit.edu	37	12	49183367	49183367	+	RNA	DEL	G	G	-	rs10711161		TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr12:49183367delG	ENST00000549864.1	+	0	9																											ccctgccccagccccagcccc	0.657													3	4	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25337049	25337050	+	RNA	DEL	GA	GA	-			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr15:25337049_25337050delGA	ENST00000546682.1	+	0	969				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						ACTGGAGCTGGAGAGAGAGAGA	0.500													7	138	---	---	---	---					
KSR1	8844	broad.mit.edu	37	17	25910015	25910016	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr17:25910015_25910016insC	ENST00000398988.3	+	5	898_899	c.453_454insC	c.(451-456)acccccfs	p.TP151fs	KSR1_ENST00000319524.6_Frame_Shift_Ins_p.TP288fs|KSR1_ENST00000509603.2_Frame_Shift_Ins_p.TP288fs|KSR1_ENST00000268763.6_Frame_Shift_Ins_p.TP151fs	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	286					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.P292fs*22(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CACCACGGACGCCCCCCCCACC	0.678													8	26	---	---	---	---					
PMEPA1	56937	broad.mit.edu	37	20	56227348	56227349	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr20:56227348_56227349insG	ENST00000341744.3	-	4	943_944	c.624_625insC	c.(622-627)ccgcagfs	p.Q209fs	PMEPA1_ENST00000395816.3_Frame_Shift_Ins_p.Q159fs|PMEPA1_ENST00000265626.4_Frame_Shift_Ins_p.Q159fs|PMEPA1_ENST00000347215.4_Frame_Shift_Ins_p.Q174fs|PMEPA1_ENST00000395814.1_Frame_Shift_Ins_p.Q159fs	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	209					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						GAGTTACTGCTGGGGGGGCAGG	0.683													7	130	---	---	---	---					
SREBF2	6721	broad.mit.edu	37	22	42262949	42262951	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr22:42262949_42262951delGCA	ENST00000361204.4	+	2	369_371	c.203_205delGCA	c.(202-207)ggc>g	p.GS68del		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	68	Gly/Pro/Ser-rich.				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						ggcagcagtggcagcagcagcag	0.567													8	116	---	---	---	---					
TCF20	6942	broad.mit.edu	37	22	42610776	42610778	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-FR-A2OS-01A-11D-A21A-08	TCGA-FR-A2OS-10B-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce829e3d-a0cd-40f6-9974-426eb4085f4f	9b315eb9-416e-4ee3-87dd-f7057c6ef2d1	g.chr22:42610776_42610778delTGC	ENST00000359486.3	-	1	670_672	c.534_536delGCA	c.(532-537)caa>ca	p.QQ178del	TCF20_ENST00000335626.4_In_Frame_Del_p.QQ178del	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	178	Poly-Gln.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CTGCTGGACTTGCTGCTGCTGCT	0.571													7	179	---	---	---	---					
