Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CRISP2	7180	broad.mit.edu	37	6	49666200	49666200	+	Missense_Mutation	SNP	G	G	A	rs148414007	by1000genomes	TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr6:49666200G>A	ENST00000339139.4	-	7	528	c.292C>T	c.(292-294)Ctc>Ttc	p.L98F		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	98						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GACATATAGAGATTCTCACCA	0.408000													33	45					0	0	0.045705	0	0
AMBP	259	broad.mit.edu	37	9	116823799	116823799	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr9:116823799G>A	ENST00000265132.3	-	8	1020	c.758C>T	c.(757-759)tCc>tTc	p.S253F		NM_001633.3	NP_001624.1	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin precursor	253	BPTI/Kunitz inhibitor 1.				cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	11					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	ACAGGCCATGGATGTACCATT	0.562000													49	52					0	0	0.139131	0	0
ZNF365	22891	broad.mit.edu	37	10	64159311	64159311	+	Silent	SNP	A	A	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr10:64159311A>T	ENST00000395254.3	+	5	1267	c.987A>T	c.(985-987)gtA>gtT	p.V329V	ZNF365_ENST00000395255.3_Intron|ZNF365_ENST00000410046.3_Intron|ZNF365_ENST00000466727.1_3'UTR	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					CGCATTCGGTATGTAACCACC	0.502000													75	79					0	0	0.139131	0	0
C5AR1	728	broad.mit.edu	37	19	47823557	47823557	+	Missense_Mutation	SNP	C	C	T	rs141160351		TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:47823557C>T	ENST00000355085.3	+	2	545	c.523C>T	c.(523-525)Cgg>Tgg	p.R175W		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	175					activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CTTCCTGTACCGGGTGGTCCG	0.632000													66	85					0	0	0.139131	0	0
CEP164	22897	broad.mit.edu	37	11	117241991	117241991	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:117241991C>T	ENST00000278935.3	+	9	1108	c.961C>T	c.(961-963)Cct>Tct	p.P321S	CEP164_ENST00000533706.1_3'UTR	NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	321					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GAAGAGTGAACCTAAGATTTG	0.527000													83	11					0	0	0.139131	0	0
CRB2	286204	broad.mit.edu	37	9	126132627	126132627	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr9:126132627G>A	ENST00000373631.3	+	7	1296	c.1295G>A	c.(1294-1296)gGa>gAa	p.G432E	CRB2_ENST00000373629.2_Missense_Mutation_p.G100E|CRB2_ENST00000359999.3_Missense_Mutation_p.G432E	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	432	EGF-like 9.|Laminin G-like 1.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						GGTACCCATGGACCGTTCTGT	0.627000													22	28					0	0	0.083992	0	0
DAW1	164781	broad.mit.edu	37	2	228754594	228754594	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:228754594G>A	ENST00000373666.2	+	3	772	c.136G>A	c.(136-138)Gaa>Aaa	p.E46K	DAW1_ENST00000309931.2_Missense_Mutation_p.E46K|DAW1_ENST00000545118.1_Missense_Mutation_p.E31K|DAW1_ENST00000472604.1_3'UTR					dynein assembly factor with WDR repeat domains 1																		TGCGTTAGTAGAAGAAATCCA	0.373000													19	23					0	0	0.055883	0	0
BIRC6	57448	broad.mit.edu	37	2	32724814	32724814	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:32724814G>A	ENST00000421745.2	+	46	8803	c.8669G>A	c.(8668-8670)cGa>cAa	p.R2890Q		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2890					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding	p.R2862L(1)|p.R2890L(1)		NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GTGGGTGCTCGAGCATGCTTT	0.438000													87	128					0	0	0.139131	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54930811	54930811	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:54930811G>A	ENST00000293373.6	+	29	3236	c.3157G>A	c.(3157-3159)Gaa>Aaa	p.E1053K	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.E1003K	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	1053					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CAAGAACATTGAAACTCACCT	0.403000													33	52					0	0	0.080422	0	0
PCNA	5111	broad.mit.edu	37	20	5100229	5100229	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:5100229G>A	ENST00000379160.3	-	2	458	c.216C>T	c.(214-216)ctC>ctT	p.L72L	PCNA_ENST00000379143.5_Silent_p.L72L	NM_002592.2	NP_002583.1	P12004	PCNA_HUMAN	proliferating cell nuclear antigen	72	Interaction with NUDT15.				cell proliferation|DNA strand elongation involved in DNA replication|mismatch repair|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|positive regulation of deoxyribonuclease activity|regulation of DNA replication|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair|translesion synthesis	cytoplasm|DNA replication factor C complex|microtubule cytoskeleton|nuclear replication fork|nucleoplasm|PCNA complex|PCNA-p21 complex	dinucleotide insertion or deletion binding|DNA polymerase processivity factor activity|MutLalpha complex binding|purine-specific mismatch base pair DNA N-glycosylase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)	9						CTCACCTGGTGAGGTTCACGC	0.692000								DNA polymerases (catalytic subunits)					6	27					0	0	0.038147	0	0
WAPAL	23063	broad.mit.edu	37	10	88211815	88211815	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr10:88211815G>A	ENST00000298767.5	-	15	3495	c.3023C>T	c.(3022-3024)tCg>tTg	p.S1008L	WAPAL_ENST00000263070.7_Intron|WAPAL_ENST00000372075.1_Intron	NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	1008	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						AAAAGAGCACGATGTTTCCAT	0.423000													27	33					0	0	0.099896	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24523737	24523737	+	Missense_Mutation	SNP	G	G	A	rs140803711	by1000genomes	TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:24523737G>A	ENST00000376862.3	+	2	637	c.4G>A	c.(4-6)Gat>Aat	p.D2N		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	2					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						GAGTACCATGGATGGCATCAT	0.507000													86	52					0	0	0.139131	0	0
KIAA1217	56243	broad.mit.edu	37	10	24508690	24508690	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr10:24508690T>C	ENST00000376454.3	+	2	236	c.206T>C	c.(205-207)cTa>cCa	p.L69P	KIAA1217_ENST00000376452.3_Missense_Mutation_p.L69P|KIAA1217_ENST00000376462.1_5'UTR|KIAA1217_ENST00000458595.1_Missense_Mutation_p.L69P	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	69					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						AGACACACCCTAGGGGGGCCC	0.502000													27	44					0	0	0.116897	0	0
TIAM2	26230	broad.mit.edu	37	6	155458566	155458566	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr6:155458566G>A	ENST00000461783.3	+	7	2723	c.1450G>A	c.(1450-1452)Gag>Aag	p.E484K	TIAM2_ENST00000529824.2_Missense_Mutation_p.E484K|TIAM2_ENST00000456144.1_Missense_Mutation_p.E484K|TIAM2_ENST00000360366.4_Missense_Mutation_p.E484K|TIAM2_ENST00000318981.5_Missense_Mutation_p.E484K|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	484					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGAAACCGCCGAGTCCAGCAG	0.532000													63	63					0	0	0.139131	0	0
MARCH1	55016	broad.mit.edu	37	4	164506934	164506934	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:164506934G>A	ENST00000503008.1	-	6	1366	c.390C>T	c.(388-390)ttC>ttT	p.F130F	MARCH1_ENST00000274056.7_Silent_p.F130F|MARCH1_ENST00000514618.1_Silent_p.F386F|MARCH1_ENST00000339875.5_Silent_p.F113F	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	130					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.F113F(1)|p.F130F(1)		endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCTCCATTATGAAGTCATACT	0.493000													44	86					0	0	0.139131	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110431459	110431459	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr8:110431459G>A	ENST00000378402.5	+	22	2598	c.2494G>A	c.(2494-2496)Gga>Aga	p.G832R		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	832					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGTGTACATTGGACACACATC	0.328000										HNSCC(38;0.096)			5	11					0	0	0.014758	0	0
PLBD1	79887	broad.mit.edu	37	12	14659974	14659974	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:14659974A>C	ENST00000240617.5	-	9	1917	c.1265T>G	c.(1264-1266)cTg>cGg	p.L422R		NM_024829.5	NP_079105.4	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	422					lipid catabolic process	extracellular region	hydrolase activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16						GTCCAAGCCCAGCTTCTGAAC	0.443000													53	51					0	0	0.139131	0	0
NWD1	284434	broad.mit.edu	37	19	16861034	16861034	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:16861034C>T	ENST00000524140.2	+	6	1999	c.1581C>T	c.(1579-1581)ctC>ctT	p.L527L	NWD1_ENST00000379808.3_Silent_p.L527L|NWD1_ENST00000552788.1_Silent_p.L527L|NWD1_ENST00000549814.1_Silent_p.L527L|NWD1_ENST00000523826.1_Silent_p.L321L|NWD1_ENST00000339803.6_Silent_p.L392L	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	527	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGGCCAGCCTCCCAGAGTGTG	0.642000													33	36					0	0	0.069456	0	0
COL7A1	1294	broad.mit.edu	37	3	48609941	48609941	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:48609941C>T	ENST00000328333.8	-	88	7038	c.6931G>A	c.(6931-6933)Gag>Aag	p.E2311K	COL7A1_ENST00000454817.1_Missense_Mutation_p.E2279K	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2311	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTCACCTTCTCTCCCTTTGCT	0.647000													34	34					0	0	0.098360	0	0
TTN	7273	broad.mit.edu	37	2	179505295	179505295	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:179505295C>T	ENST00000589042.1	-	221	40920	c.40696G>A	c.(40696-40698)Gaa>Aaa	p.E13566K	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E4693K|TTN_ENST00000591111.1_Missense_Mutation_p.E11925K|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E10998K|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E4501K|TTN-AS1_ENST00000418062.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E4626K|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11925	Ig-like 92.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTTCCTTTCCCTTTTTGTA	0.318000													49	78					0	0	0.139131	0	0
ABCB1	5243	broad.mit.edu	37	7	87144571	87144571	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:87144571G>A	ENST00000265724.3	-	26	3675	c.3258C>T	c.(3256-3258)ttC>ttT	p.F1086F	ABCB1_ENST00000543898.1_Silent_p.F1022F|ABCB1_ENST00000488737.2_5'UTR	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1086	ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AGGGGTCGTAGAACCGCTCCA	0.517000													24	33					0	0	0.116897	0	0
DICER1	23405	broad.mit.edu	37	14	95571499	95571499	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr14:95571499G>A	ENST00000526495.1	-	22	3469	c.3178C>T	c.(3178-3180)Cgc>Tgc	p.R1060C	DICER1_ENST00000556045.1_5'UTR|DICER1_ENST00000541352.1_Missense_Mutation_p.R1060C|DICER1_ENST00000527414.1_Missense_Mutation_p.R1060C|DICER1_ENST00000343455.3_Missense_Mutation_p.R1060C|DICER1_ENST00000393063.1_Missense_Mutation_p.R1060C			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1060					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CAGTGAAGGCGATAAAGTATG	0.498000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				6	86					0	0	0.029380	0	0
OR8B12	219858	broad.mit.edu	37	11	124412728	124412728	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:124412728G>A	ENST00000306842.2	-	1	847	c.823C>T	c.(823-825)Ctg>Ttg	p.L275L		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		GTATAGAACAGGGAGGACACT	0.433000													36	1					0	0	0.059317	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187712480	187712480	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:187712480G>A	ENST00000295131.2	-	2	247	c.208C>T	c.(208-210)Ccg>Tcg	p.P70S		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	70					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			CCTCCTTTCGGAAATGTGGAA	0.348000													37	31					0	0	0.111260	0	0
SLC4A11	83959	broad.mit.edu	37	20	3215509	3215509	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:3215509G>A	ENST00000380059.3	-	3	350	c.249C>T	c.(247-249)ttC>ttT	p.F83F	SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000380056.3_Silent_p.F56F|SLC4A11_ENST00000539553.1_Silent_p.F40F	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	56					cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity	p.F56F(1)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						CTCGGGCTTCGAAGGTGTCAT	0.547000													20	64					0	0	0.055883	0	0
FAM173B	134145	broad.mit.edu	37	5	10236718	10236718	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr5:10236718C>T	ENST00000511437.1	-	3	328	c.316G>A	c.(316-318)Gct>Act	p.A106T	FAM173B_ENST00000280330.8_5'UTR|FAM173B_ENST00000510047.1_Missense_Mutation_p.A106T|FAM173B_ENST00000510052.1_5'UTR	NM_199133.3	NP_954584.2	Q6P4H8	F173B_HUMAN	family with sequence similarity 173, member B	106						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	16						TTCTTCGCAGCCGCTATGACC	0.408000													33	23					0	0	0.059317	0	0
ROBO2	6092	broad.mit.edu	37	3	77147226	77147226	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:77147226C>T	ENST00000461745.1	+	2	1023	c.123C>T	c.(121-123)atC>atT	p.I41I	ROBO2_ENST00000332191.8_Silent_p.I41I|ROBO2_ENST00000487694.3_Silent_p.I57I	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	41	Ig-like C2-type 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CCGATGTCATCGTCTCTAAGG	0.547000													13	20					0	0	0.093190	0	0
ST13	6767	broad.mit.edu	37	22	41223178	41223178	+	Silent	SNP	T	T	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr22:41223178T>G	ENST00000216218.3	-	11	1384	c.903A>C	c.(901-903)ggA>ggC	p.G301G		NM_003932.3	NP_003923.2	P50502	F10A1_HUMAN	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	301	Gly/Met/Pro-rich.						protein binding, bridging			cervix(1)|large_intestine(1)|lung(3)|skin(1)	6						GCATGCCCCCTCCCATTCCAG	0.453000													200	8					0	0	0.139131	0	0
PPFIA4	8497	broad.mit.edu	37	1	203015491	203015491	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr1:203015491G>A	ENST00000367240.2	+	9	1648	c.1121G>A	c.(1120-1122)aGa>aAa	p.R374K	PPFIA4_ENST00000295706.4_5'UTR|PPFIA4_ENST00000447715.2_Missense_Mutation_p.R374K|PPFIA4_ENST00000414050.2_Missense_Mutation_p.R81K			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0	SAM 1.				cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						CTGGCCCAGAGAATTGCAGCC	0.652000													4	7					0	0	0.009096	0	0
ZNF43	7594	broad.mit.edu	37	19	21991924	21991924	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:21991924C>A	ENST00000594012.1	-	7	1411	c.897G>T	c.(895-897)aaG>aaT	p.K299N	ZNF43_ENST00000354959.4_Missense_Mutation_p.K305N|ZNF43_ENST00000598381.1_Missense_Mutation_p.K299N|ZNF43_ENST00000595461.1_Missense_Mutation_p.K299N	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		GATGAATTTTCTTATGTTCAG	0.368000													31	23					4.74835e-14	5.86825e-14	0.045705	1	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522815	95522815	+	RNA	SNP	A	A	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:95522815A>G	ENST00000432432.2	-	0	212					NR_040113.1																						ATCTTCTGCAATTCGGAGTCC	0.652000													4	85					0	0	0.047766	0	0
OR4K14	122740	broad.mit.edu	37	14	20483000	20483000	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr14:20483000G>A	ENST00000305045.2	-	1	352	c.353C>T	c.(352-354)tCc>tTc	p.S118F		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ATAGGCCATGGAAACCAGGAG	0.468000													27	25					0	0	0.091800	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609948	84609948	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr9:84609948G>A	ENST00000344803.2	+	4	4610	c.4563G>A	c.(4561-4563)agG>agA	p.R1521R		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		TGCCCCACAGGAAGCCTGTGC	0.537000													10	16					0	0	0.058154	0	0
TSN	7247	broad.mit.edu	37	2	122522899	122522899	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:122522899C>T	ENST00000389682.3	+	6	890	c.643C>T	c.(643-645)Cgg>Tgg	p.R215W	TSN_ENST00000409193.1_Missense_Mutation_p.R210W|TSN_ENST00000536142.1_3'UTR|TSN_ENST00000498545.1_3'UTR	NM_001261401.1|NM_004622.2	NP_001248330.1|NP_004613.1	Q15631	TSN_HUMAN	translin	215					DNA recombination	cytoplasm|nucleus	sequence-specific DNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(3)|skin(1)	12		Ovarian(717;0.0563)|Prostate(154;0.116)				TCTCTCCATCCGGGGCTTTAA	0.512000													49	68					0	0	0.139131	0	0
VRK2	7444	broad.mit.edu	37	2	58373490	58373490	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:58373490G>A	ENST00000435505.2	+	15	1808	c.1063G>A	c.(1063-1065)Gca>Aca	p.A355T	VRK2_ENST00000340157.4_Missense_Mutation_p.A355T|VRK2_ENST00000412104.2_Missense_Mutation_p.A355T|VRK2_ENST00000440705.2_Missense_Mutation_p.A332T|VRK2_ENST00000417641.2_Missense_Mutation_p.A355T			Q86Y07	VRK2_HUMAN	vaccinia related kinase 2	355						integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	24						AGTCAACAAGGCACACAATAG	0.363000													16	23					0	0	0.146539	0	0
DNAH11	8701	broad.mit.edu	37	7	21658816	21658816	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:21658816G>A	ENST00000328843.6	+	24	4399	c.4368G>A	c.(4366-4368)gcG>gcA	p.A1456A	DNAH11_ENST00000409508.3_Silent_p.A1451A|DNAH11_ENST00000465593.1_3'UTR			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1456	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGGACAAGGCGGTGAAAGAGC	0.443000									Kartagener syndrome				11	14					0	0	0.069234	0	0
ARMC4	55130	broad.mit.edu	37	10	28270414	28270414	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr10:28270414G>A	ENST00000305242.5	-	7	1009	c.917C>T	c.(916-918)tCa>tTa	p.S306L	ARMC4_ENST00000545014.1_5'UTR|ARMC4_ENST00000537576.1_5'UTR|ARMC4_ENST00000239715.3_Missense_Mutation_p.S163L|ARMC4_ENST00000480504.1_5'UTR	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	306							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						CATATTTTCTGAAAATTTTGG	0.289000													38	52					0	0	0.074837	0	0
CADM2	253559	broad.mit.edu	37	3	86010782	86010782	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:86010782G>A	ENST00000383699.3	+	8	1582	c.955G>A	c.(955-957)Gtt>Att	p.V319I	CADM2_ENST00000407528.2_Missense_Mutation_p.V310I|CADM2_ENST00000405615.2_Missense_Mutation_p.V312I	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	310	Thr-rich.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TGCGGAATATGTTCTCATTGT	0.358000													26	44					0	0	0.108266	0	0
PROM2	150696	broad.mit.edu	37	2	95944471	95944471	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:95944471G>A	ENST00000317620.9	+	9	1186	c.1053G>A	c.(1051-1053)gaG>gaA	p.E351E	PROM2_ENST00000542147.1_Silent_p.E351E|PROM2_ENST00000317668.4_Silent_p.E351E|PROM2_ENST00000403131.2_Silent_p.E351E	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	351						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						TCCTGCAGGAGAACAGCACCT	0.637000													33	34					0	0	0.059317	0	0
SUPT5H	6829	broad.mit.edu	37	19	39960881	39960881	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:39960881C>T	ENST00000599117.1	+	18	1864	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	SUPT5H_ENST00000432763.2_Silent_p.F499F|SUPT5H_ENST00000402194.2_Silent_p.F495F|SUPT5H_ENST00000359191.6_Silent_p.F495F|SUPT5H_ENST00000598725.1_Silent_p.F499F			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	499	KOW 3.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGGAGAATTTCGTTATCCTGT	0.552000													76	87					0	0	0.139131	0	0
ZNF701	55762	broad.mit.edu	37	19	53085502	53085502	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:53085502G>A	ENST00000540331.1	+	5	613	c.388G>A	c.(388-390)Ggc>Agc	p.G130S	ZNF701_ENST00000391785.3_Missense_Mutation_p.G64S|ZNF701_ENST00000301093.2_Missense_Mutation_p.G130S|CTD-3099C6.7_ENST00000599222.1_RNA	NM_001172655.1	NP_001166126.1	Q9NV72	ZN701_HUMAN	zinc finger protein 701	64					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(6)	14				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		AACAGGACAAGGCAATACAGA	0.358000													26	33					0	0	0.134883	0	0
CPNE1	8904	broad.mit.edu	37	20	34218407	34218407	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:34218407C>T	ENST00000317619.3	-	15	1450	c.1056G>A	c.(1054-1056)tcG>tcA	p.S352S	CPNE1_ENST00000352393.4_Silent_p.S352S|CPNE1_ENST00000317677.5_Silent_p.S357S|CPNE1_ENST00000397442.1_Silent_p.S352S|CPNE1_ENST00000397446.1_Silent_p.S352S|CPNE1_ENST00000397443.1_Silent_p.S352S|CPNE1_ENST00000397445.1_Silent_p.S352S			Q99829	CPNE1_HUMAN	copine I	352	VWFA.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			breast(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CAAATTCATGCGAGACCTGGA	0.488000													7	587					0	0	0.038147	0	0
MEMO1	51072	broad.mit.edu	37	2	32093518	32093518	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:32093518G>A	ENST00000295065.4	-	9	1115	c.806C>T	c.(805-807)tCg>tTg	p.S269L	DPY30_ENST00000446765.1_5'UTR|MEMO1_ENST00000426310.2_Missense_Mutation_p.S246L|MEMO1_ENST00000490459.1_5'UTR|MEMO1_ENST00000404530.1_Missense_Mutation_p.S269L|MEMO1_ENST00000379383.3_Missense_Mutation_p.S272L	NM_015955.2	NP_057039.1	Q9Y316	MEMO1_HUMAN	mediator of cell motility 1	269					regulation of microtubule-based process	cytosol|nucleus				NS(1)|breast(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	17	Acute lymphoblastic leukemia(172;0.155)					ATTCAAAAACGAAAAACTCAT	0.423000													4	8					0	0	0.014758	0	0
BBS7	55212	broad.mit.edu	37	4	122749834	122749834	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:122749834G>A	ENST00000264499.4	-	16	1909	c.1726C>T	c.(1726-1728)Cta>Tta	p.L576L	BBS7_ENST00000506636.1_Silent_p.L576L	NM_176824.2	NP_789794.1	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7	576					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						ACATCTTTTAGGATGGAGATA	0.269000									Bardet-Biedl syndrome				14	22					0	0	0.033300	0	0
ALG10	84920	broad.mit.edu	37	12	34179315	34179315	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:34179315C>T	ENST00000266483.2	+	3	1206	c.887C>T	c.(886-888)tCa>tTa	p.S296L	RP11-847H18.2_ENST00000501954.2_RNA|ALG10_ENST00000538927.1_Intron	NM_032834.3	NP_116223.3	Q5BKT4	AG10A_HUMAN	ALG10, alpha-1,2-glucosyltransferase	296					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				TACTTTTTTTCATTTACTCTC	0.348000													47	80					0	0	0.139131	0	0
MYO18B	84700	broad.mit.edu	37	22	26194047	26194047	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr22:26194047C>T	ENST00000335473.7	+	12	2754	c.2504C>T	c.(2503-2505)gCg>gTg	p.A835V	MYO18B_ENST00000536101.1_Missense_Mutation_p.A835V|MYO18B_ENST00000407587.2_Missense_Mutation_p.A835V	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	835	Myosin head-like.		A -> G (in a lung squamous cell carcinoma sample; somatic mutation).			nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity	p.A835E(1)		NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CACCTGGGTGCGGCGGGGGCC	0.662000													10	2					0	0	0.093190	0	0
GRIN3A	116443	broad.mit.edu	37	9	104375733	104375733	+	Silent	SNP	A	A	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr9:104375733A>G	ENST00000361820.3	-	6	3291	c.2691T>C	c.(2689-2691)caT>caC	p.H897H	GRIN3A_ENST00000479772.1_5'UTR	NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	897					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CCATAAACCCATGTGACTTGT	0.458000													26	34					0	0	0.099896	0	0
SLC6A20	54716	broad.mit.edu	37	3	45801384	45801384	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:45801384C>T	ENST00000358525.4	-	10	1709	c.1594G>A	c.(1594-1596)Ggg>Agg	p.G532R	SLC6A20_ENST00000456124.2_Missense_Mutation_p.G532R|SLC6A20_ENST00000353278.4_Missense_Mutation_p.G495R	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	532					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		TTCAGGGTCCCCGTGAGGATG	0.587000													69	73					0	0	0.139131	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117789273	117789273	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:117789273G>A	ENST00000528626.1	-	2	375	c.302C>T	c.(301-303)tCc>tTc	p.S101F	TMPRSS13_ENST00000526090.1_Missense_Mutation_p.S101F|TMPRSS13_ENST00000524993.1_Missense_Mutation_p.S101F|TMPRSS13_ENST00000430170.2_Missense_Mutation_p.S101F|TMPRSS13_ENST00000445164.2_Missense_Mutation_p.S101F	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	96					proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		TGACCTGCCGGATGAGGACCT	0.627000													19	6					0	0	0.043863	0	0
CMYA5	202333	broad.mit.edu	37	5	79029992	79029992	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr5:79029992G>A	ENST00000446378.2	+	2	5435	c.5404G>A	c.(5404-5406)Gta>Ata	p.V1802I		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1802						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTCATCCCAGGTACTCCAGAG	0.393000													40	72					0	0	0.080422	0	0
TAT	6898	broad.mit.edu	37	16	71606176	71606176	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr16:71606176C>T	ENST00000355962.4	-	6	752	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	207					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	GCTGTCTTTTCATCAATTAGA	0.418000													24	42					0	0	0.083992	0	0
PYGM	5837	broad.mit.edu	37	11	64522219	64522219	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:64522219G>A	ENST00000164139.3	-	8	1343	c.945C>T	c.(943-945)tcC>tcT	p.S315S	PYGM_ENST00000377432.3_Silent_p.S227S	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	315					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	AGCCGAACTTGGAAGACTTGA	0.587000													11	19					0	0	0.080935	0	0
GFRAL	389400	broad.mit.edu	37	6	55216059	55216059	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr6:55216059G>A	ENST00000340465.2	+	5	465	c.379G>A	c.(379-381)Ggg>Agg	p.G127R		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	127						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGGATTCAAAGGGATGTGGTC	0.433000													86	100					0	0	0.139131	0	0
SUCO	51430	broad.mit.edu	37	1	172546697	172546697	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr1:172546697A>G	ENST00000263688.3	+	12	1501	c.1282A>G	c.(1282-1284)Aag>Gag	p.K428E	SUCO_ENST00000367723.3_Intron	NM_014283.3	NP_055098.1			SUN domain containing ossification factor																		CAAGTACATAAAGGTTAGCAA	0.318000													19	32					0	0	0.043863	0	0
CCDC73	493860	broad.mit.edu	37	11	32636297	32636297	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:32636297C>T	ENST00000335185.5	-	16	1610	c.1567G>A	c.(1567-1569)Gaa>Aaa	p.E523K		NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	523										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					TTGTCTTTTTCCAAGCATATC	0.318000													36	57					0	0	0.080422	0	0
LPAR4	2846	broad.mit.edu	37	X	78010805	78010805	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chrX:78010805C>T	ENST00000435339.2	+	2	844	c.439C>T	c.(439-441)Cgt>Tgt	p.R147C	LPAR4_ENST00000373301.2_Missense_Mutation_p.R147C	NM_005296.2	NP_005287.1	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	147						integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						TTTTCGATCTCGTACTATTAG	0.463000													54	4					0	0	0.139131	0	0
C12orf77	196415	broad.mit.edu	37	12	25148886	25148886	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:25148886A>G	ENST00000549828.1	-	3	466	c.262T>C	c.(262-264)Tgc>Cgc	p.C88R	C12orf77_ENST00000434912.3_Missense_Mutation_p.C33R|C12orf77_ENST00000549262.1_Missense_Mutation_p.C33R	NM_001101339.1	NP_001094809.1	C9JDV5	CL097_HUMAN	chromosome 12 open reading frame 77	88										endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	7						TTCTGGTGGCATTCGGGGGCA	0.507000													23	31					0	0	0.076483	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													8	84					0	0	0.069234	0	0
LRIT1	26103	broad.mit.edu	37	10	85991885	85991885	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr10:85991885C>T	ENST00000372105.3	-	4	1691	c.1670G>A	c.(1669-1671)cGa>cAa	p.R557Q		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	557						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						GAAGCACTTTCGGCAGCGCTT	0.567000													27	19					0	0	0.091800	0	0
UNK	85451	broad.mit.edu	37	17	73780856	73780856	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr17:73780856G>A	ENST00000293218.3	+	2	123	c.123G>A	c.(121-123)ggG>ggA	p.G41G	H3F3B_ENST00000586607.1_Intron|UNK_ENST00000589666.1_5'UTR			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	0							nucleic acid binding|zinc ion binding			cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCGTGTGGGGGGTCTTCACGT	0.612000													7	13					0	0	0.047766	0	0
TSC22D4	81628	broad.mit.edu	37	7	100071977	100071977	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:100071977G>A	ENST00000300181.2	-	3	1603	c.849C>T	c.(847-849)ttC>ttT	p.F283F	TSC22D4_ENST00000496728.1_5'UTR|TSC22D4_ENST00000393991.1_Silent_p.F44F	NM_030935.3	NP_112197.1	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	283					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTACTGCTCCGAAGGGGTCTG	0.607000													27	29					0	0	0.099896	0	0
ZNF43	7594	broad.mit.edu	37	19	21991634	21991634	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:21991634T>C	ENST00000594012.1	-	7	1701	c.1187A>G	c.(1186-1188)gAa>gGa	p.E396G	ZNF43_ENST00000354959.4_Missense_Mutation_p.E402G|ZNF43_ENST00000598381.1_Missense_Mutation_p.E396G|ZNF43_ENST00000595461.1_Missense_Mutation_p.E396G	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TTTGCCACATTCTTCACATTT	0.363000													30	25					0	0	0.134883	0	0
MST1R	4486	broad.mit.edu	37	3	49933263	49933263	+	Silent	SNP	C	C	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:49933263C>A	ENST00000296474.3	-	12	2874	c.2847G>T	c.(2845-2847)ggG>ggT	p.G949G	MST1R_ENST00000344206.4_Silent_p.G900G	NM_002447.2	NP_002438.2	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	949					cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CCCCATCTGGCCCTGGCCGCA	0.622000													21	37					5.35356e-11	6.55436e-11	0.076483	1	0
HHLA2	11148	broad.mit.edu	37	3	108072555	108072555	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:108072555G>A	ENST00000357759.5	+	4	760	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	HHLA2_ENST00000491820.1_Missense_Mutation_p.E116K|HHLA2_ENST00000489514.2_Missense_Mutation_p.E116K|HHLA2_ENST00000467562.1_Missense_Mutation_p.E52K|HHLA2_ENST00000467761.1_Missense_Mutation_p.E116K	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	116	Ig-like V-type 1.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						CCTTCTGGACGAAGGAATTTA	0.398000													22	36					0	0	0.069288	0	0
AREL1	9870	broad.mit.edu	37	14	75142897	75142897	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr14:75142897G>A	ENST00000356357.4	-	7	1294	c.779C>T	c.(778-780)tCa>tTa	p.S260L	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		ATTTTGGTATGAAATGCAAGC	0.408000													22	4					0	0	0.062417	0	0
UQCC1	55245	broad.mit.edu	37	20	33894523	33894523	+	Silent	SNP	C	C	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:33894523C>G	ENST00000374385.5	-	9	888	c.711G>C	c.(709-711)cgG>cgC	p.R237R	UQCC_ENST00000542501.1_3'UTR|UQCC_ENST00000540457.1_Silent_p.R82R|UQCC_ENST00000407996.2_Silent_p.R100R|UQCC_ENST00000397556.3_Silent_p.R138R|UQCC_ENST00000359226.2_Silent_p.R157R|UQCC_ENST00000374377.5_Silent_p.R125R|UQCC_ENST00000374380.2_Silent_p.R169R|UQCC_ENST00000374384.2_Silent_p.R211R|UQCC_ENST00000349714.5_Silent_p.R210R	NM_018244.4	NP_060714.3	Q9NVA1	UQCC_HUMAN		237						cytoplasmic membrane-bounded vesicle				breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	17			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CTTCACATTTCCGGTTGAAGA	0.542000											OREG0025889	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	202	55					0	0	0.139131	0	0
MMP15	4324	broad.mit.edu	37	16	58079224	58079224	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr16:58079224G>A	ENST00000219271.3	+	10	2669	c.1884G>A	c.(1882-1884)atG>atA	p.M628I		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	628					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						ACGTGGTGATGGTGCTGGTGC	0.662000													13	21					0	0	0.105934	0	0
KRTAP12-3	386683	broad.mit.edu	37	21	46078116	46078116	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr21:46078116G>A	ENST00000397907.1	+	1	268	c.220G>A	c.(220-222)Ggg>Agg	p.G74R	TSPEAR_ENST00000323084.4_Intron	NM_198697.2	NP_941970.2	P60328	KR123_HUMAN	keratin associated protein 12-3	74	14 X 5 AA approximate repeats.					intermediate filament				central_nervous_system(1)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						CCAATCTTCGGGGTGCTGCCA	0.647000													40	6					0	0	0.098360	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522727	95522727	+	RNA	SNP	C	C	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:95522727C>A	ENST00000432432.2	-	0	300					NR_040113.1													p.R64L(2)									CTGCTTGTCCCGGGCGTCCAG	0.731000													5	56					0.000274275	0.000326637	0.047766	1	0
CPNE9	151835	broad.mit.edu	37	3	9754249	9754249	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:9754249G>A	ENST00000383832.3	+	8	592	c.402G>A	c.(400-402)ggG>ggA	p.G134G	CPNE9_ENST00000383831.3_Silent_p.G134G	NM_153635.2	NP_705899.2	Q8IYJ1	CPNE9_HUMAN	copine family member IX	134	C2 2.									breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16	Medulloblastoma(99;0.227)					AGAAGTGTGGGACCATATTGC	0.532000													28	50					0	0	0.050027	0	0
UROC1	131669	broad.mit.edu	37	3	126219548	126219548	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:126219548C>T	ENST00000290868.2	-	11	1188	c.1135G>A	c.(1135-1137)Gtc>Atc	p.V379I	UROC1_ENST00000383579.3_Missense_Mutation_p.V439I	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	379					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		CTTTCCTGGACCAGGTCCTTG	0.597000													39	53					0	0	0.124865	0	0
PDLIM3	27295	broad.mit.edu	37	4	186435436	186435436	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:186435436G>A	ENST00000284770.5	-	4	459	c.386C>T	c.(385-387)cCg>cTg	p.P129L	PDLIM3_ENST00000284771.6_Intron|PDLIM3_ENST00000284767.5_3'UTR	NM_014476.5	NP_055291.2	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain 3	129						sarcomere	zinc ion binding	p.P129Q(1)		breast(2)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		GCTTCGGCCCGGGATCACGAA	0.453000													40	4					0	0	0.124865	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659734	24659734	+	RNA	SNP	T	T	C			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr22:24659734T>C	ENST00000414583.2	+	0	3259					NR_003714.1																						CTCTCTCCTGTGGGAGGGGGG	0.632000													3	9					0	0	0.115264	0	0
MYO16	23026	broad.mit.edu	37	13	109379904	109379904	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr13:109379904C>T	ENST00000356711.2	+	4	540	c.414C>T	c.(412-414)aaC>aaT	p.N138N	MYO16_ENST00000357550.2_Silent_p.N138N|MYO16_ENST00000251041.5_Silent_p.N138N	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	138					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCTGCGATAACCCTGATATTG	0.403000													53	33					0	0	0.139131	0	0
TTYH3	80727	broad.mit.edu	37	7	2686504	2686504	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:2686504G>A	ENST00000258796.7	+	2	346	c.141G>A	c.(139-141)ggG>ggA	p.G47G	TTYH3_ENST00000407643.1_Silent_p.G47G	NM_025250.2	NP_079526.1	Q9C0H2	TTYH3_HUMAN	tweety family member 3	47						chloride channel complex|plasma membrane	chloride channel activity			kidney(1)|large_intestine(3)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	17		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		TGCTCCTGGGGGCCGCCGCCC	0.731000													42	4					0	0	0.139131	0	0
HLA-DOA	3111	broad.mit.edu	37	6	32975833	32975833	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr6:32975833C>T	ENST00000229829.5	-	2	363	c.288G>A	c.(286-288)ctG>ctA	p.L96L	HLA-DOA_ENST00000450833.2_Silent_p.L66L|HLA-DOA_ENST00000495532.1_5'UTR	NM_002119.3	NP_002110.1	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO alpha	96	Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	9						CCAGGATGTCCAGATGGGCTT	0.637000													25	54					0	0	0.099896	0	0
ZNF581	51545	broad.mit.edu	37	19	56156051	56156051	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:56156051C>T	ENST00000587252.1	+	2	387	c.114C>T	c.(112-114)tcC>tcT	p.S38S	ZNF581_ENST00000588537.1_Silent_p.S38S|ZNF581_ENST00000270451.5_Silent_p.S38S			Q9P0T4	ZN581_HUMAN	zinc finger protein 581	38					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CTTCCTCCTCCATCGGATCTC	0.612000													4	7					0	0	0.014758	0	0
DAO	1610	broad.mit.edu	37	12	109278890	109278890	+	Silent	SNP	G	G	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:109278890G>T	ENST00000228476.3	+	2	312	c.108G>T	c.(106-108)gcG>gcT	p.A36A	DAO_ENST00000551281.1_Silent_p.A36A	NM_001917.4	NP_001908.3	P14920	OXDA_HUMAN	D-amino-acid oxidase	36					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|skin(1)	26						AGGTCTACGCGGACCGCTTCA	0.622000													44	52					5.73435e-26	7.12038e-26	0.139131	1	0
KLF6	1316	broad.mit.edu	37	10	3824211	3824211	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr10:3824211C>G	ENST00000497571.1	-	2	558	c.298G>C	c.(298-300)Gag>Cag	p.E100Q	KLF6_ENST00000542957.1_Missense_Mutation_p.E100Q|KLF6_ENST00000469435.1_Missense_Mutation_p.E100Q|KLF6_ENST00000173785.4_5'UTR	NM_001160124.1|NM_001300.5	NP_001153596.1|NP_001291.3	Q99612	KLF6_HUMAN	Kruppel-like factor 6	100					B cell differentiation	nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				Colorectal(1;0.238)		CTGTTGGTCTCTAAGTTGTAA	0.507000											OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	121	119					0	0	0.139131	0	0
DMGDH	29958	broad.mit.edu	37	5	78359493	78359493	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr5:78359493C>T	ENST00000255189.3	-	2	247	c.219G>A	c.(217-219)atG>atA	p.M73I	DMGDH_ENST00000540686.1_5'UTR|DMGDH_ENST00000520388.1_Intron|DMGDH_ENST00000380311.4_Missense_Mutation_p.E29K	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	73					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		CCACATCTTTCATCCCTGCTT	0.488000													36	68					0	0	0.064281	0	0
PCLO	27445	broad.mit.edu	37	7	82582166	82582166	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:82582166C>T	ENST00000423517.2	-	5	8440	c.8103G>A	c.(8101-8103)gaG>gaA	p.E2701E	PCLO_ENST00000333891.8_Silent_p.E2701E	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2632					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GAGCAAGAGGCTCTGGAGGAA	0.403000													14	27					0	0	0.119110	0	0
TRBV24-1	28563	broad.mit.edu	37	7	142364267	142364267	+	RNA	SNP	T	T	C			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:142364267T>C	ENST00000390397.2	+	0	70																											TGGGGCCTTTTATCTCCTGGG	0.498000													12	16					0	0	0.119110	0	0
MAT2A	4144	broad.mit.edu	37	2	85770052	85770052	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:85770052C>T	ENST00000306434.3	+	8	1103	c.980C>T	c.(979-981)cCa>cTa	p.P327L	MAT2A_ENST00000409017.1_Missense_Mutation_p.P264L	NM_005911.5	NP_005902.1	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	327					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	9					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	GTTTCTCATCCATTATCTATC	0.378000													39	74					0	0	0.098360	0	0
OR7G1	125962	broad.mit.edu	37	19	9225585	9225585	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:9225585C>T	ENST00000293614.1	-	1	854	c.855G>A	c.(853-855)atG>atA	p.M285I	OR7G1_ENST00000541538.1_Missense_Mutation_p.M285I			Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G, member 1	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	20						TGAAGGGGTTCATCATTTGAG	0.443000													47	42					0	0	0.139131	0	0
UBR3	130507	broad.mit.edu	37	2	170930037	170930037	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:170930037C>T	ENST00000272793.5	+	36	5169	c.5119C>T	c.(5119-5121)Cca>Tca	p.P1707S	UBR3_ENST00000418381.1_Missense_Mutation_p.P1707S|UBR3_ENST00000392631.1_Missense_Mutation_p.P528S			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1707					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						TCTGGATTGGCCAGTTCCAGC	0.403000													5	109					0	0	0.021553	0	0
GIGYF1	64599	broad.mit.edu	37	7	100281709	100281709	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:100281709G>A	ENST00000275732.5	-	15	3011	c.1802C>T	c.(1801-1803)cCg>cTg	p.P601L		NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	601	Gln-rich.|Poly-Pro.									central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CTGCTGTGGCGGCGGCGGTGG	0.677000													21	18					0	0	0.099896	0	0
DPYD	1806	broad.mit.edu	37	1	97981303	97981303	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr1:97981303G>A	ENST00000370192.3	-	13	1819	c.1719C>T	c.(1717-1719)acC>acT	p.T573T		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	573					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AGAAAGTTTTGGTGAGGGCAA	0.333000													35	38					0	0	0.080422	0	0
DSN1	79980	broad.mit.edu	37	20	35387003	35387003	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:35387003G>A	ENST00000426836.1	-	7	980	c.608C>T	c.(607-609)tCt>tTt	p.S203F	DSN1_ENST00000373740.3_Missense_Mutation_p.S131F|DSN1_ENST00000448110.1_Missense_Mutation_p.S187F|DSN1_ENST00000373734.4_Missense_Mutation_p.S96F|DSN1_ENST00000373750.4_Missense_Mutation_p.S203F|DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000373745.3_Missense_Mutation_p.S203F	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	203					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				TGCTTCCAAAGAAAAATCTGA	0.289000													43	134					0	0	0.139131	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6083437	6083437	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:6083437C>T	ENST00000409021.3	-	6	1449	c.1000G>A	c.(1000-1002)Gag>Aag	p.E334K	JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.E169K|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.E334K|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.E334K|JAKMIP1_ENST00000410077.2_Missense_Mutation_p.E169K	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	334	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TTGTTCTTCTCCACCAGGGGC	0.522000													31	33					0	0	0.045705	0	0
DMRT3	58524	broad.mit.edu	37	9	990879	990879	+	Silent	SNP	A	A	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr9:990879A>G	ENST00000190165.2	+	2	1331	c.1293A>G	c.(1291-1293)gaA>gaG	p.E431E		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	431					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GCGCCACGGAAGACCCTCGGA	0.547000													38	42					0	0	0.080422	0	0
DNAH5	1767	broad.mit.edu	37	5	13735336	13735336	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr5:13735336C>T	ENST00000265104.4	-	68	11769	c.11665G>A	c.(11665-11667)Gag>Aag	p.E3889K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3889					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTGTGCTCCTCGTACAGCCCT	0.458000									Kartagener syndrome				23	72					0	0	0.076483	0	0
ODF2	4957	broad.mit.edu	37	9	131256911	131256911	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr9:131256911C>T	ENST00000303890.5	+	19	2388	c.1803C>T	c.(1801-1803)atC>atT	p.I601I	ODF2_ENST00000444119.2_Silent_p.I601I|ODF2_ENST00000546203.1_Silent_p.I606I|ODF2_ENST00000372807.5_Silent_p.I620I|ODF2_ENST00000372814.3_Silent_p.I669I|ODF2_ENST00000372796.4_Silent_p.I625I|ODF2_ENST00000434106.2_Silent_p.I625I|ODF2_ENST00000393533.2_Silent_p.I625I|ODF2_ENST00000351030.3_Silent_p.I620I|ODF2_ENST00000448249.3_Silent_p.I544I|ODF2_ENST00000372791.3_Silent_p.I606I	NM_002540.4	NP_002531.3	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2	625					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			autonomic_ganglia(1)|breast(7)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	37						GGAAGAACATCGACCTCACAG	0.597000													26	32					0	0	0.108266	0	0
ZMYM3	9203	broad.mit.edu	37	X	70467680	70467680	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chrX:70467680C>A	ENST00000373998.1	-	12	2749	c.2052G>T	c.(2050-2052)caG>caT	p.Q684H	ZMYM3_ENST00000353904.2_Missense_Mutation_p.Q684H|ZMYM3_ENST00000373984.3_Missense_Mutation_p.Q686H|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373988.1_Missense_Mutation_p.Q686H|ZMYM3_ENST00000314425.5_Missense_Mutation_p.Q684H	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	684					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					GCTGGCAGGTCTGGGAGCAGT	0.527000													13	0					0.000219431	0.000262516	0.119110	1	0
OSBPL10	114884	broad.mit.edu	37	3	31743863	31743863	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:31743863C>T	ENST00000396556.2	-	7	1355	c.1233G>A	c.(1231-1233)atG>atA	p.M411I	OSBPL10_ENST00000438237.2_Missense_Mutation_p.M347I	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	411					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		TGGTCAAATCCATTCCAAGTT	0.428000													11	27					0	0	0.080935	0	0
DSCR10	259234	broad.mit.edu	37	21	39580587	39580587	+	RNA	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr21:39580587G>A	ENST00000432141.1	+	0	709					NR_027695.1																						CTAACATTTGGAAACATTTAG	0.353000													84	14					0	0	0.139131	0	0
MECOM	2122	broad.mit.edu	37	3	168819935	168819935	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:168819935G>A	ENST00000464456.1	-	9	3293	c.2093C>T	c.(2092-2094)tCa>tTa	p.S698L	MECOM_ENST00000472280.1_Missense_Mutation_p.S708L|MECOM_ENST00000392736.3_Missense_Mutation_p.S707L|MECOM_ENST00000433243.2_Missense_Mutation_p.S708L|MECOM_ENST00000468789.1_Missense_Mutation_p.S707L|MECOM_ENST00000264674.3_Missense_Mutation_p.S772L|MECOM_ENST00000460814.1_Missense_Mutation_p.S698L|MECOM_ENST00000494292.1_Missense_Mutation_p.S886L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						AGAGGGCACTGACTGTAAGAG	0.507000													28	23					0	0	0.099896	0	0
BAGE2	85319	broad.mit.edu	37	21	11058288	11058288	+	RNA	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr21:11058288G>A	ENST00000470054.1	-	0	359									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CACAGCATTTGATAGTGGCTC	0.403000													11	130					0	0	0.069234	0	0
STAB2	55576	broad.mit.edu	37	12	103984724	103984724	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:103984724G>A	ENST00000388887.2	+	2	335	c.131G>A	c.(130-132)cGa>cAa	p.R44Q		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	44					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						ACCGAGTGCCGATCCTGCGCT	0.433000													31	37					0	0	0.134883	0	0
KHDC3L	154288	broad.mit.edu	37	6	74072991	74072991	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr6:74072991G>A	ENST00000370367.3	+	2	396	c.343G>A	c.(343-345)Gcg>Acg	p.A115T		NM_001017361.2	NP_001017361.1			KH domain containing 3-like, subcortical maternal complex member																		CCAGCTCCAGGCGAAAGGTAC	0.582000													37	46					0	0	0.074837	0	0
SLC12A5	57468	broad.mit.edu	37	20	44685019	44685019	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:44685019G>A	ENST00000454036.1	+	23	3071	c.2995G>A	c.(2995-2997)Gat>Aat	p.D999N	SLC12A5_ENST00000243964.3_Missense_Mutation_p.D976N	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	999					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCTGATCCACGATCAGAGTGC	0.627000													8	41					0	0	0.038147	0	0
TADA2B	93624	broad.mit.edu	37	4	7056555	7056555	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:7056555C>T	ENST00000310074.7	+	2	1226	c.1037C>T	c.(1036-1038)cCa>cTa	p.P346L	TADA2B_ENST00000512388.1_Missense_Mutation_p.P271L|TADA2B_ENST00000515646.1_Missense_Mutation_p.P254L	NM_152293.2	NP_689506.2	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2B	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding			breast(3)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	18						GAGAACCTTCCAGGCTTCGAG	0.512000													49	58					0	0	0.139131	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50191101	50191101	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:50191101G>A	ENST00000335999.6	-	8	743	c.542C>T	c.(541-543)tCc>tTc	p.S181F		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	177	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						AAGGAACGGGGATAGGGCATC	0.647000													13	20					0	0	0.105934	0	0
WDR1	9948	broad.mit.edu	37	4	10100722	10100722	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:10100722C>T	ENST00000382452.2	-	4	553	c.271G>A	c.(271-273)Gag>Aag	p.E91K	WDR1_ENST00000502702.1_Intron|WDR1_ENST00000382451.2_Intron|WDR1_ENST00000499869.2_Missense_Mutation_p.E91K	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	91					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		AACAGGTGCTCCTTCTGCGTG	0.597000													30	47					0	0	0.050027	0	0
CDK5RAP1	51654	broad.mit.edu	37	20	31973529	31973529	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:31973529G>A	ENST00000357886.4	-	7	956	c.803C>T	c.(802-804)cCt>cTt	p.P268L	CDK5RAP1_ENST00000346416.2_Missense_Mutation_p.P268L|CDK5RAP1_ENST00000452723.3_Missense_Mutation_p.P178L|CDK5RAP1_ENST00000339269.5_Missense_Mutation_p.P268L|CDK5RAP1_ENST00000473997.1_5'UTR|CDK5RAP1_ENST00000544843.1_Missense_Mutation_p.P268L			Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	268					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(12)|ovary(3)|skin(3)|urinary_tract(1)	26						CCGGGTGAAAGGAACAATGCA	0.498000													41	181					0	0	0.092188	0	0
THAP10	56906	broad.mit.edu	37	15	71174870	71174870	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr15:71174870C>T	ENST00000249861.4	-	3	1209	c.697G>A	c.(697-699)Gat>Aat	p.D233N	LRRC49_ENST00000544974.2_Intron	NM_020147.3	NP_064532.1	Q9P2Z0	THA10_HUMAN	THAP domain containing 10	233							DNA binding|metal ion binding			NS(1)|kidney(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						CAGTCTGTATCTGTTTCTGAA	0.383000													54	79					0	0	0.139131	0	0
FAM129C	199786	broad.mit.edu	37	19	17648329	17648329	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:17648329G>A	ENST00000335393.4	+	6	803	c.665G>A	c.(664-666)gGt>gAt	p.G222D	FAM129C_ENST00000595684.1_Missense_Mutation_p.G222D|FAM129C_ENST00000352727.3_Missense_Mutation_p.G222D|FAM129C_ENST00000599164.1_Missense_Mutation_p.G191D|FAM129C_ENST00000332386.5_Missense_Mutation_p.G222D|FAM129C_ENST00000600871.1_Missense_Mutation_p.G168D|FAM129C_ENST00000300971.2_Missense_Mutation_p.G222D|FAM129C_ENST00000599124.1_Missense_Mutation_p.G191D|FAM129C_ENST00000601861.1_Missense_Mutation_p.G191D|FAM129C_ENST00000449408.2_5'UTR	NM_173544.4	NP_775815.2	Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	222										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						GCCCTGCAGGGTGGCATCCGG	0.642000													39	40					0	0	0.098360	0	0
CSMD3	114788	broad.mit.edu	37	8	113275867	113275867	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr8:113275867C>T	ENST00000297405.5	-	61	10107		c.e61+1		CSMD3_ENST00000455883.2_Splice_Site|CSMD3_ENST00000352409.3_Splice_Site|CSMD3_ENST00000343508.3_Splice_Site	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3							integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATCATACTTACGTAAGCACTG	0.388000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	12					0	0	0.069234	0	0
CCDC146	57639	broad.mit.edu	37	7	76903049	76903049	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:76903049G>A	ENST00000285871.4	+	10	1339	c.1212G>A	c.(1210-1212)gaG>gaA	p.E404E	CCDC146_ENST00000415740.2_Intron|CCDC146_ENST00000431197.1_Intron	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	404										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				CATTATCTGAGAGAAGGCGAG	0.378000													46	54					0	0	0.139131	0	0
PHOX2B	8929	broad.mit.edu	37	4	41747973	41747973	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:41747973C>A	ENST00000226382.2	-	3	1155	c.796G>T	c.(796-798)Gct>Tct	p.A266S		NM_003924.3	NP_003915.2	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	266					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity	p.A266T(1)		autonomic_ganglia(7)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	30						GGGCCCCCAGCCGCAGCCAGG	0.771000			"""Mis, F"""		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				6	9					2.0095e-06	2.43745e-06	0.029380	1	0
CCDC60	160777	broad.mit.edu	37	12	119968748	119968748	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:119968748G>A	ENST00000327554.2	+	13	1896	c.1431G>A	c.(1429-1431)gtG>gtA	p.V477V	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	477										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		AGATCCTGGTGAAACTGCAGA	0.498000													51	50					0	0	0.139131	0	0
SCNN1D	6339	broad.mit.edu	37	1	1221515	1221515	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr1:1221515C>T	ENST00000338555.2	+	4	1420	c.276C>T	c.(274-276)tcC>tcT	p.S92S	SCNN1D_ENST00000400928.3_Silent_p.S92S|SCNN1D_ENST00000379116.5_Silent_p.S256S|SCNN1D_ENST00000325425.8_Silent_p.S158S					sodium channel, non-voltage-gated 1, delta subunit											lung(6)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GGCTGCTGTCCCTGGGAGCCC	0.677000													9	11					0	0	0.058154	0	0
ABCC8	6833	broad.mit.edu	37	11	17498277	17498277	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:17498277C>A	ENST00000302539.4	-	1	172	c.47G>T	c.(46-48)cGg>cTg	p.R16L	ABCC8_ENST00000389817.3_Missense_Mutation_p.R16L	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	16					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CTGGTCCACCCGGTAGGCGGC	0.682000													5	238					0.00116845	0.00137898	0.021553	1	0
FCAR	2204	broad.mit.edu	37	19	55401098	55401098	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:55401098C>T	ENST00000391723.3	+	4	623	c.623C>T	c.(622-624)aCt>aTt	p.T208I	FCAR_ENST00000353758.4_Silent_p.L136L|FCAR_ENST00000482092.2_3'UTR|FCAR_ENST00000355524.3_Silent_p.L245L|FCAR_ENST00000391725.3_Silent_p.L223L|FCAR_ENST00000391724.3_Silent_p.L211L|FCAR_ENST00000391726.3_Silent_p.L137L|FCAR_ENST00000345937.4_Silent_p.L149L|FCAR_ENST00000359272.4_Silent_p.L233L	NM_133274.2	NP_579808.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	0					immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		CTTGGCCATACTGGTTGAAAA	0.542000													153	166					0	0	0.139131	0	0
KMT2C	58508	broad.mit.edu	37	7	151849907	151849907	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:151849907C>T	ENST00000355193.2	-	50	12798	c.12580G>A	c.(12580-12582)Gag>Aag	p.E4194K	KMT2C_ENST00000262189.6_Missense_Mutation_p.E4137K					lysine (K)-specific methyltransferase 2C																		TGTCGATACTCCAAACCCGGG	0.522000													47	56					0	0	0.139131	0	0
CYP4F8	11283	broad.mit.edu	37	19	15739173	15739173	+	RNA	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:15739173C>T	ENST00000441682.2	+	0	1238							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						GCGGTTGCATCCCCCAATCCC	0.612000													53	62					0	0	0.139131	0	0
MCM8	84515	broad.mit.edu	37	20	5953775	5953775	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:5953775C>T	ENST00000378896.3	+	12	1705	c.1328C>T	c.(1327-1329)cCa>cTa	p.P443L	MCM8_ENST00000378886.2_Missense_Mutation_p.P483L|MCM8_ENST00000378883.1_Intron|MCM8_ENST00000265187.4_Missense_Mutation_p.P427L	NM_032485.4|NM_182802.1	NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	443	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						AACAGAATTCCAATTCGGGGA	0.413000													48	34					0	0	0.139131	0	0
HNF1B	6928	broad.mit.edu	37	17	36093584	36093584	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr17:36093584C>T	ENST00000225893.4	-	3	1136	c.775G>A	c.(775-777)Gaa>Aaa	p.E259K	HNF1B_ENST00000561193.1_Missense_Mutation_p.E233K|HNF1B_ENST00000427275.2_Missense_Mutation_p.E233K|HNF1B_ENST00000560016.1_Missense_Mutation_p.E259K	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	259					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E259Q(1)		breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TCTCTCTCTTCCTTGCTGGGG	0.587000													201	241					0	0	0.139131	0	0
TPCN2	219931	broad.mit.edu	37	11	68822718	68822718	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:68822718G>A	ENST00000294309.3	+	4	428	c.327G>A	c.(325-327)gcG>gcA	p.A109A	TPCN2_ENST00000442692.2_3'UTR|TPCN2_ENST00000542467.1_Silent_p.A109A	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	109					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CCAGCACGGCGGACGTGCGCT	0.587000													35	61					0	0	0.050027	0	0
GLRB	2743	broad.mit.edu	37	4	158059978	158059978	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:158059978G>A	ENST00000264428.4	+	7	898	c.628G>A	c.(628-630)Gat>Aat	p.D210N	GLRB_ENST00000541722.1_Missense_Mutation_p.D210N|GLRB_ENST00000509282.1_Missense_Mutation_p.D210N|GLRB_ENST00000512619.1_Intron	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	210					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity	p.D210N(1)		central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	CACAACTGATGATTTACGATT	0.259000													38	56					0	0	0.117977	0	0
CDH23	64072	broad.mit.edu	37	10	73437212	73437212	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr10:73437212G>A	ENST00000224721.6	+	15	1534		c.e15-1		CDH23_ENST00000299366.7_Splice_Site	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23						calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GCCTGGCACAGGTTCTCGCTG	0.577000													3	6					0	0	0.115264	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44505869	44505869	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:44505869C>T	ENST00000255152.2	+	2	881	c.672C>T	c.(670-672)caC>caT	p.H224H	ZSWIM3_ENST00000454862.2_Silent_p.H218H	NM_080752.3	NP_542790.2	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM-type containing 3	224							zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	35		Myeloproliferative disorder(115;0.0122)				TCTTGCTACACCGGGTGGAGA	0.557000													42	171					0	0	0.111260	0	0
CLU	1191	broad.mit.edu	37	8	27462570	27462570	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr8:27462570G>A	ENST00000316403.10	-	5	1105	c.700C>T	c.(700-702)Ccg>Tcg	p.P234S	CLU_ENST00000523500.1_Missense_Mutation_p.P234S|CLU_ENST00000560366.1_Missense_Mutation_p.P286S|CLU_ENST00000546343.1_Missense_Mutation_p.P245S|CLU_ENST00000405140.3_Missense_Mutation_p.P234S			P10909	CLUS_HUMAN	clusterin	234					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		GGCTCGTACGGAGAGAAGGGC	0.592000													32	47					0	0	0.064281	0	0
PGD	5226	broad.mit.edu	37	1	10479478	10479478	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr1:10479478C>T	ENST00000538557.1	+	12	1419	c.1175C>T	c.(1174-1176)tCc>tTc	p.S392F	PGD_ENST00000498356.1_3'UTR|PGD_ENST00000541529.1_Missense_Mutation_p.S383F|PGD_ENST00000270776.8_Missense_Mutation_p.S405F			P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	405					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	14	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		GCTCAGGACTCCTGGCGGCGG	0.522000													42	59					0	0	0.131918	0	0
ETV5	2119	broad.mit.edu	37	3	185783821	185783821	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:185783821G>A	ENST00000306376.5	-	8	937	c.691C>T	c.(691-693)Cct>Tct	p.P231S	ETV5_ENST00000434744.1_Missense_Mutation_p.P231S|ETV5_ENST00000537818.1_Missense_Mutation_p.P273S	NM_004454.2	NP_004445.1	P41161	ETV5_HUMAN	ets variant 5	231					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|cervix(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	28	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			CCTGGCTGAGGAGGGAAGGGG	0.488000			T	"""TMPRSS2, SCL45A3"""	Prostate								32	37					0	0	0.045705	0	0
CYP2C19	1557	broad.mit.edu	37	10	96535148	96535148	+	Splice_Site	SNP	A	A	G	rs5030781		TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr10:96535148A>G	ENST00000371321.3	+	3	415	c.331_splice	c.e3-1	p.G111_splice	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	111					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TCCTGTTAGGAATCGTTTTCA	0.532000													38	34					0	0	0.080422	0	0
CSMD1	64478	broad.mit.edu	37	8	3008933	3008933	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr8:3008933A>G	ENST00000520002.1	-	41	6575	c.6020T>C	c.(6019-6021)tTa>tCa	p.L2007S	CSMD1_ENST00000602723.1_Missense_Mutation_p.L2007S|CSMD1_ENST00000400186.3_Missense_Mutation_p.L2007S|CSMD1_ENST00000602557.1_Missense_Mutation_p.L2007S|CSMD1_ENST00000542608.1_Missense_Mutation_p.L2006S|CSMD1_ENST00000539096.1_Missense_Mutation_p.L2006S|CSMD1_ENST00000537824.1_Missense_Mutation_p.L2006S|CSMD1_ENST00000523387.1_5'UTR			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2007	CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCCGATGGGTAATGAGATCCT	0.448000													5	6					0	0	0.021553	0	0
MN1	4330	broad.mit.edu	37	22	28194068	28194068	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr22:28194068G>A	ENST00000302326.4	-	1	3418	c.2464C>T	c.(2464-2466)Cag>Tag	p.Q822*		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	822							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						AGGCAGCTCTGGCCGAACAGG	0.627000			T	ETV6	"""AML, meningioma"""								44	10					0	0	0.117977	0	0
UNC93A	54346	broad.mit.edu	37	6	167709750	167709750	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr6:167709750G>A	ENST00000230256.3	+	3	674		c.e3+1		UNC93A_ENST00000366829.2_Splice_Site	NM_018974.3	NP_061847.2	Q86WB7	UN93A_HUMAN	unc-93 homolog A (C. elegans)							integral to membrane|plasma membrane		p.?(1)		breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	40		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CCCAGCCAAGGTAAAAGGAAA	0.502000													31	52					0	0	0.050027	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													6	73					0	0	0.047766	0	0
PRKAR2B	5577	broad.mit.edu	37	7	106685403	106685403	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:106685403G>A	ENST00000265717.4	+	1	310	c.51G>A	c.(49-51)acG>acA	p.T17T		NM_002736.2	NP_002727.2	P31323	KAP3_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, beta	17	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	14						AGGGCTTCACGGTGGAGGTGC	0.726000													3	8					0	0	0.115264	0	0
ACAN	176	broad.mit.edu	37	15	89402420	89402420	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr15:89402420C>T	ENST00000439576.2	+	12	6978	c.6604C>T	c.(6604-6606)Ctg>Ttg	p.L2202L	ACAN_ENST00000559004.1_Silent_p.L2202L|ACAN_ENST00000561243.1_Silent_p.L2202L|ACAN_ENST00000352105.7_Silent_p.L2202L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2202					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CAGCGGAGACCTGTCTGGTCA	0.602000													42	40					0	0	0.111260	0	0
ADH1B	125	broad.mit.edu	37	4	100237120	100237120	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:100237120C>T	ENST00000305046.8	-	5	569	c.502G>A	c.(502-504)Gag>Aag	p.E168K	ADH1B_ENST00000394887.3_Missense_Mutation_p.E128K			P00325	ADH1B_HUMAN	alcohol dehydrogenase 1B (class I), beta polypeptide	168					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	33				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	CAGACTTTCTCCAGGGGCGAG	0.517000													39	72					0	0	0.098360	0	0
TP63	8626	broad.mit.edu	37	3	189455576	189455576	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:189455576G>A	ENST00000264731.3	+	2	199	c.110G>A	c.(109-111)cGa>cAa	p.R37Q	TP63_ENST00000392460.3_Missense_Mutation_p.R37Q|TP63_ENST00000440651.2_Missense_Mutation_p.R37Q|TP63_ENST00000418709.2_Missense_Mutation_p.R37Q|TP63_ENST00000382063.4_Missense_Mutation_p.R37Q|TP63_ENST00000320472.5_Missense_Mutation_p.R37Q	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	37	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		AGTTATTACCGATCCACCATG	0.373000										HNSCC(45;0.13)			23	29					0	0	0.091800	0	0
GLRA3	8001	broad.mit.edu	37	4	175709987	175709987	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:175709987C>T	ENST00000274093.3	-	2	681	c.179G>A	c.(178-180)aGa>aAa	p.R60K	GLRA3_ENST00000340217.5_Missense_Mutation_p.R60K	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	60					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GGGTCTGATTCTTGCATCATA	0.358000													24	33					0	0	0.108266	0	0
TJP3	27134	broad.mit.edu	37	19	3736281	3736281	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:3736281G>A	ENST00000541714.2	+	11	1708	c.1246G>A	c.(1246-1248)Gac>Aac	p.D416N	TJP3_ENST00000587686.1_Missense_Mutation_p.D435N|TJP3_ENST00000539908.2_Missense_Mutation_p.D380N|TJP3_ENST00000262968.9_Missense_Mutation_p.D449N|TJP3_ENST00000382008.3_Missense_Mutation_p.D430N|TJP3_ENST00000589378.1_Missense_Mutation_p.D425N	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	430	PDZ 3.					tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCCCGGCCGACGGGCAGGG	0.687000													13	12					0	0	0.105934	0	0
GALNT8	26290	broad.mit.edu	37	12	4835834	4835834	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:4835834G>A	ENST00000252318.2	+	2	685	c.348G>A	c.(346-348)atG>atA	p.M116I	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	116						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.M116I(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						AAACCCAAATGAAACTCTTCC	0.498000													15	17					0	0	0.119110	0	0
TCEB3CL	728929	broad.mit.edu	37	18	44549197	44549197	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr18:44549197C>T	ENST00000451265.1	-	1	1337	c.1102G>A	c.(1102-1104)Gaa>Aaa	p.E368K	KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron	NM_001100817.1	NP_001094287.1			transcription elongation factor B polypeptide 3C-like											central_nervous_system(1)|lung(1)|prostate(1)	3						GTCCACCCTTCCAGAACGGGT	0.607000													39	1453					0	0	0.108266	0	0
CNBD2	140894	broad.mit.edu	37	20	34571961	34571961	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:34571961C>T	ENST00000373973.3	+	5	638	c.465C>T	c.(463-465)ttC>ttT	p.F155F	CNBD2_ENST00000538900.1_Silent_p.F155F|CNBD2_ENST00000349339.1_Silent_p.F155F					cyclic nucleotide binding domain containing 2																		GCTTTTATTTCATCTACCTGG	0.522000													158	41					0	0	0.139131	0	0
EFR3A	23167	broad.mit.edu	37	8	132998461	132998461	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr8:132998461G>A	ENST00000254624.5	+	17	2115	c.1890G>A	c.(1888-1890)atG>atA	p.M630I	EFR3A_ENST00000334503.4_Missense_Mutation_p.M630I|EFR3A_ENST00000519656.1_Missense_Mutation_p.M594I	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	630						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TTCGAACTATGGAAGCCCCTT	0.333000													8	28					0	0	0.093190	0	0
IGHV3-74	28408	broad.mit.edu	37	14	107219125	107219125	+	RNA	SNP	T	T	C			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr14:107219125T>C	ENST00000424969.2	-	0	240																											CAGCCCAAACTCCATGGTGAG	0.502000													52	16					0	0	0.139131	0	0
FSHB	2488	broad.mit.edu	37	11	30255226	30255226	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:30255226C>T	ENST00000417547.1	+	3	308	c.269C>T	c.(268-270)tCc>tTc	p.S90F	FSHB_ENST00000533718.1_Missense_Mutation_p.S90F|FSHB_ENST00000254122.3_Missense_Mutation_p.S90F	NM_001018080.1	NP_001018090.1	P01225	FSHB_HUMAN	follicle stimulating hormone, beta polypeptide	90					cellular nitrogen compound metabolic process|female gamete generation|female pregnancy|ovarian follicle development|peptide hormone processing|progesterone biosynthetic process|spermatogenesis|transforming growth factor beta receptor signaling pathway	cytoplasm|extracellular region|soluble fraction	follicle-stimulating hormone activity|protein heterodimerization activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(3)|skin(1)	12					Follitropin beta(DB00066)|Thyrotropin Alfa(DB00024)|Urofollitropin(DB00094)	CATGCAGATTCCTTGTATACA	0.537000													34	35					0	0	0.064281	0	0
TBC1D12	23232	broad.mit.edu	37	10	96201752	96201752	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr10:96201752G>A	ENST00000225235.4	+	2	1181	c.1071G>A	c.(1069-1071)caG>caA	p.Q357Q		NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12	357				Q -> G (in Ref. 3; CAB43225).		intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				AGAATCTTCAGAAAACATCCA	0.358000													18	27					0	0	0.049695	0	0
KRT13	3860	broad.mit.edu	37	17	39659243	39659243	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr17:39659243G>A	ENST00000246635.3	-	4	889	c.843C>T	c.(841-843)taC>taT	p.Y281Y	KRT13_ENST00000587544.1_Silent_p.Y281Y|KRT13_ENST00000336861.3_Silent_p.Y281Y	NM_153490.2	NP_705694.2	P13646	K1C13_HUMAN	keratin 13	281	Coil 2.|Rod.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				CCATGGCCTCGTACTGCTCCC	0.612000													101	110					0	0	0.139131	0	0
RPLP0P6	220717	broad.mit.edu	37	2	38709407	38709407	+	RNA	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:38709407C>T	ENST00000417039.1	-	0	696																											CTCCTTTTTCCAGGCTTTAGG	0.552000													18	26					0	0	0.049695	0	0
ZNF581	51545	broad.mit.edu	37	19	56156050	56156050	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:56156050C>T	ENST00000587252.1	+	2	386	c.113C>T	c.(112-114)tCc>tTc	p.S38F	ZNF581_ENST00000588537.1_Missense_Mutation_p.S38F|ZNF581_ENST00000270451.5_Missense_Mutation_p.S38F			Q9P0T4	ZN581_HUMAN	zinc finger protein 581	38					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CCTTCCTCCTCCATCGGATCT	0.612000													4	7					0	0	0.014758	0	0
TECR	9524	broad.mit.edu	37	19	14674675	14674675	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:14674675T>A	ENST00000436007.2	+	6	396	c.272T>A	c.(271-273)cTg>cAg	p.L91Q	TECR_ENST00000596164.1_3'UTR|TECR_ENST00000215567.5_Missense_Mutation_p.L76Q|TECR_ENST00000596073.1_5'UTR|TECR_ENST00000600083.1_5'UTR			Q9NZ01	TECR_HUMAN	trans-2,3-enoyl-CoA reductase	76					fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity			endometrium(1)|large_intestine(1)|ovary(1)	3						ACGGCCACACTGTACTTCCGG	0.642000													35	29					0	0	0.059317	0	0
BMP5	653	broad.mit.edu	37	6	55684502	55684502	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr6:55684502C>T	ENST00000370830.3	-	2	1332	c.634G>A	c.(634-636)Gaa>Aaa	p.E212K	BMP5_ENST00000446683.2_Missense_Mutation_p.E212K	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	212					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TTAATTGTTTCATTTTCAAAT	0.323000													24	23					0	0	0.108266	0	0
C5AR1	728	broad.mit.edu	37	19	47823556	47823556	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:47823556C>T	ENST00000355085.3	+	2	544	c.522C>T	c.(520-522)taC>taT	p.Y174Y		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	174					activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CCTTCCTGTACCGGGTGGTCC	0.637000													66	86					0	0	0.139131	0	0
FAM179A	165186	broad.mit.edu	37	2	29240119	29240119	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:29240119C>A	ENST00000379558.4	+	9	1495	c.1144C>A	c.(1144-1146)Cag>Aag	p.Q382K	FAM179A_ENST00000465300.1_Intron|FAM179A_ENST00000403861.2_Missense_Mutation_p.Q382K	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	382							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CAGGACAGGGCAGGAGCTCAC	0.602000													17	35					0.000566183	0.000671222	0.033300	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147926820	147926820	+	Silent	SNP	A	A	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:147926820A>G	ENST00000361727.3	+	20	3846	c.3330A>G	c.(3328-3330)ggA>ggG	p.G1110G	CNTNAP2_ENST00000538075.1_Silent_p.G169G	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1110	Laminin G-like 4.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGGCCAATGGACAGCCCCACA	0.423000										HNSCC(39;0.1)			10	17					0	0	0.058154	0	0
MCF2L2	23101	broad.mit.edu	37	3	182925450	182925450	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:182925450C>T	ENST00000328913.3	-	23	2955	c.2658G>A	c.(2656-2658)atG>atA	p.M886I	MCF2L2_ENST00000468976.1_5'UTR|MCF2L2_ENST00000473233.1_Missense_Mutation_p.M886I	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	886	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CCCCAGGCTCCATTCGTATCT	0.433000													48	78					0	0	0.139131	0	0
NRAS	4893	broad.mit.edu	37	1	115256530	115256530	+	Missense_Mutation	SNP	G	G	T	rs121913254		TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr1:115256530G>T	ENST00000369535.4	-	3	434	c.181C>A	c.(181-183)Caa>Aaa	p.Q61K		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61K(595)|p.Q61E(9)|p.Q61L(3)|p.Q61R(2)|p.G60>?(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTCTTGTCCAGCTGTA	0.458000	Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(HCC15_LUNG)|Q61K(HS936T_SKIN)|Q61K(HS944T_SKIN)|Q61K(HT1080_SOFT_TISSUE)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH1299_LUNG)|Q61K(NCIH2087_LUNG)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(TYKNU_OVARY)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			70	84					6.88731e-43	8.59274e-43	0.139131	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125282027	125282027	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:125282027G>T	ENST00000431078.1	+	9	1836	c.1472G>T	c.(1471-1473)gGa>gTa	p.G491V		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	491	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TACTATTTTGGAGGTAAATTC	0.438000													4	10					2.56e-06	3.09088e-06	0.009096	1	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	RNA	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr15:102515299G>A	ENST00000557932.1	+	0	1145																		p.G374S(10)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGGGGGCATCGGCAAGGCCAA	0.652000													3	15					0	0	0.115264	0	0
OR5H6	79295	broad.mit.edu	37	3	97983771	97983771	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:97983771G>A	ENST00000383696.2	+	1	684	c.643G>A	c.(643-645)Gtt>Att	p.V215I	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						CTTTCTAATGGTTTTTATTTT	0.289000													29	19					0	0	0.108266	0	0
ZNF714	148206	broad.mit.edu	37	19	21299966	21299966	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:21299966C>T	ENST00000596143.1	+	5	821	c.496C>T	c.(496-498)Cat>Tat	p.H166Y	ZNF714_ENST00000601416.1_3'UTR|ZNF714_ENST00000596053.1_Intron|ZNF714_ENST00000291770.7_3'UTR	NM_182515.3	NP_872321.2	Q96N38	ZN714_HUMAN	zinc finger protein 714	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|urinary_tract(2)	18						TAAAAGAATTCATATTAGAGA	0.348000													18	34					0	0	0.043863	0	0
LANCL2	55915	broad.mit.edu	37	7	55466279	55466279	+	Silent	SNP	T	T	C			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:55466279T>C	ENST00000254770.2	+	3	1064	c.486T>C	c.(484-486)taT>taC	p.Y162Y	LANCL2_ENST00000486376.1_3'UTR	NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	162					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			CTGTGATTTATCACAAACTCA	0.488000													13	40					0	0	0.119110	0	0
PIK3R1	5295	broad.mit.edu	37	5	67576528	67576528	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr5:67576528C>T	ENST00000521381.1	+	6	1423	c.807C>T	c.(805-807)agC>agT	p.S269S	PIK3R1_ENST00000274335.5_Silent_p.S269S|PIK3R1_ENST00000396611.1_Silent_p.S269S|PIK3R1_ENST00000521657.1_Silent_p.S269S	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	269	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	AAATTTTCAGCCCTATGCTTT	0.393000			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			56	30					0	0	0.139131	0	0
OR2T12	127064	broad.mit.edu	37	1	248458416	248458416	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr1:248458416G>A	ENST00000317996.1	-	1	464	c.465C>T	c.(463-465)ctC>ctT	p.L155L		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CAGCCTGCAGGAGGCCGTCAG	0.607000													43	47					0	0	0.131918	0	0
NCOR2	9612	broad.mit.edu	37	12	124856917	124856917	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:124856917G>A	ENST00000356219.3	-	21	2613	c.2458C>T	c.(2458-2460)Cct>Tct	p.P820S	NCOR2_ENST00000429285.2_Missense_Mutation_p.P802S|NCOR2_ENST00000405201.1_Missense_Mutation_p.P820S|NCOR2_ENST00000397355.1_Missense_Mutation_p.P803S|NCOR2_ENST00000404621.1_Missense_Mutation_p.P802S|NCOR2_ENST00000404121.2_Missense_Mutation_p.P373S	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	820	Pro-rich.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGGACCACAGGAGGAGGTGCA	0.716000													7	10					0	0	0.029380	0	0
RRP9	9136	broad.mit.edu	37	3	51971239	51971239	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:51971239G>A	ENST00000232888.6	-	6	559	c.486C>T	c.(484-486)ttC>ttT	p.F162F		NM_004704.3	NP_004695.1	O43818	U3IP2_HUMAN	ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)	162					rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|skin(1)	21				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		TGGCAGCAGAGAAGATGGCTG	0.607000													64	66					0	0	0.139131	0	0
WNK1	65125	broad.mit.edu	37	12	988854	988854	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:988854C>T	ENST00000315939.6	+	11	3132	c.2489C>T	c.(2488-2490)cCg>cTg	p.P830L	WNK1_ENST00000537687.1_Intron|WNK1_ENST00000535572.1_Intron|WNK1_ENST00000530271.2_Missense_Mutation_p.P1328L|WNK1_ENST00000340908.4_Missense_Mutation_p.P423L	NM_018979.3	NP_061852.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	830					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GTGGGACAGCCGCTCCCTACT	0.542000													67	85					0	0	0.139131	0	0
PRR5L	79899	broad.mit.edu	37	11	36467960	36467960	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:36467960G>A	ENST00000378867.3	+	8	910	c.555G>A	c.(553-555)tcG>tcA	p.S185S	PRR5L_ENST00000311599.5_Intron|PRR5L_ENST00000530639.1_Silent_p.S185S|PRR5L_ENST00000527487.1_Silent_p.S185S|PRR5L_ENST00000389693.3_Intron	NM_024841.4	NP_079117.3	Q6MZQ0	PRR5L_HUMAN	proline rich 5 like	185										breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)	19						AGCTGCCCTCGTCCATTGTCC	0.587000													24	29					0	0	0.108266	0	0
MARCH6	10299	broad.mit.edu	37	5	10430029	10430029	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr5:10430029T>A	ENST00000274140.5	+	25	2663	c.2531T>A	c.(2530-2532)tTa>tAa	p.L844*	MARCH6_ENST00000449913.2_Nonsense_Mutation_p.L796*|MARCH6_ENST00000510792.1_Nonsense_Mutation_p.L542*|MARCH6_ENST00000503788.1_Nonsense_Mutation_p.L739*	NM_005885.2	NP_005876.2	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	844					protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(35)|ovary(1)|urinary_tract(3)	54						ATGCAAAACTTAGTCCATCGG	0.388000													46	26					0	0	0.139131	0	0
MAB21L3	126868	broad.mit.edu	37	1	116675835	116675835	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr1:116675835G>A	ENST00000369500.3	+	7	1203	c.938G>A	c.(937-939)aGg>aAg	p.R313K		NM_152367.2	NP_689580.2	Q8N8X9	MB213_HUMAN	mab-21-like 3 (C. elegans)	313										breast(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|urinary_tract(1)	19						CGCCTGGTGAGGAAACTGCAC	0.512000													28	28					0	0	0.125774	0	0
SP140	11262	broad.mit.edu	37	2	231177389	231177389	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:231177389G>A	ENST00000392045.3	+	27	2708	c.2594G>A	c.(2593-2595)gGg>gAg	p.G865E	SP140_ENST00000486687.2_Intron|SP140_ENST00000350136.5_Missense_Mutation_p.G734E|SP140_ENST00000343805.6_Missense_Mutation_p.G805E|SP140_ENST00000420434.3_Missense_Mutation_p.G838E|SP140_ENST00000417495.3_Missense_Mutation_p.G751E	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	865					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GAAACAAATGGGAACAATTGA	0.408000													22	41					0	0	0.083992	0	0
KMT2C	58508	broad.mit.edu	37	7	151849908	151849908	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:151849908C>T	ENST00000355193.2	-	50	12797	c.12579G>A	c.(12577-12579)ttG>ttA	p.L4193L	KMT2C_ENST00000262189.6_Silent_p.L4136L					lysine (K)-specific methyltransferase 2C																		GTCGATACTCCAAACCCGGGT	0.522000													50	58					0	0	0.139131	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55020187	55020187	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr18:55020187A>G	ENST00000324000.3	+	1	2144	c.110A>G	c.(109-111)aAc>aGc	p.N37S		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	37					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		AAAAAGGAGAACATCTTCACC	0.602000													27	37					0	0	0.116897	0	0
MAGT1	84061	broad.mit.edu	37	X	77112989	77112989	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chrX:77112989G>T	ENST00000358075.6	-	4	578	c.492C>A	c.(490-492)aaC>aaA	p.N164K		NM_032121.5	NP_115497.4	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	132					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				cervix(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	17						CTGAATTCATGTTTAGCTGAA	0.368000													5	62					2.17888e-05	2.61865e-05	0.058154	1	0
CACNA1G	8913	broad.mit.edu	37	17	48695411	48695411	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr17:48695411G>A	ENST00000352832.5	+	29	5499	c.5127G>A	c.(5125-5127)gtG>gtA	p.V1709V	CACNA1G_ENST00000513689.2_Silent_p.V1698V|CACNA1G_ENST00000507510.2_Silent_p.V1743V|CACNA1G_ENST00000505165.1_Silent_p.V1743V|CACNA1G_ENST00000503485.1_Silent_p.V1709V|CACNA1G_ENST00000510366.1_Silent_p.V1691V|CACNA1G_ENST00000512389.1_Silent_p.V1732V|CACNA1G_ENST00000359106.5_Silent_p.V1743V|CACNA1G_ENST00000502264.1_Silent_p.V1720V|CACNA1G_ENST00000429973.2_Silent_p.V1725V|CACNA1G_ENST00000514079.1_Silent_p.V1750V|CACNA1G_ENST00000360761.4_Silent_p.V1720V|CACNA1G_ENST00000358244.5_Silent_p.V1709V|CACNA1G_ENST00000513964.1_Silent_p.V1698V|CACNA1G_ENST00000514181.1_Silent_p.V1718V|CACNA1G_ENST00000507336.1_Silent_p.V1732V|CACNA1G_ENST00000515765.1_Silent_p.V1732V|CACNA1G_ENST00000515411.1_Silent_p.V1725V|CACNA1G_ENST00000354983.4_Silent_p.V1709V|CACNA1G_ENST00000442258.2_Silent_p.V1702V|CACNA1G_ENST00000507896.1_Silent_p.V1732V|CACNA1G_ENST00000514717.1_Silent_p.V1686V|CACNA1G_ENST00000507609.1_Silent_p.V1736V|CACNA1G_ENST00000515165.1_Silent_p.V1743V|CACNA1G_ENST00000510115.1_Silent_p.V1709V	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1743					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TTTTCCAGGTGGGGAACCTGG	0.557000													19	23					0	0	0.055883	0	0
LPHN3	23284	broad.mit.edu	37	4	62761482	62761482	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr4:62761482G>A	ENST00000512091.1	+	10	2360	c.1613G>A	c.(1612-1614)gGa>gAa	p.G538E	LPHN3_ENST00000545650.1_Missense_Mutation_p.G538E|LPHN3_ENST00000507164.1_Missense_Mutation_p.G606E|LPHN3_ENST00000514591.1_Missense_Mutation_p.G538E|LPHN3_ENST00000507625.1_Missense_Mutation_p.G606E|LPHN3_ENST00000506746.1_Missense_Mutation_p.G606E|LPHN3_ENST00000514157.1_Missense_Mutation_p.G538E|LPHN3_ENST00000511324.1_Missense_Mutation_p.G606E|LPHN3_ENST00000508946.1_Missense_Mutation_p.G538E|LPHN3_ENST00000509896.1_Missense_Mutation_p.G606E|LPHN3_ENST00000506720.1_Missense_Mutation_p.G606E|LPHN3_ENST00000506700.1_Missense_Mutation_p.G538E|LPHN3_ENST00000508693.1_Missense_Mutation_p.G606E|LPHN3_ENST00000504896.1_Missense_Mutation_p.G538E|LPHN3_ENST00000514996.1_Missense_Mutation_p.G538E			Q9HAR2	LPHN3_HUMAN	latrophilin 3	538					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						GCTCCTGATGGAATTTGGGAT	0.373000													9	14					0	0	0.058154	0	0
TMEM26	219623	broad.mit.edu	37	10	63170314	63170314	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr10:63170314C>T	ENST00000399298.3	-	6	1241	c.873G>A	c.(871-873)gcG>gcA	p.A291A	TMEM26_ENST00000507507.1_5'UTR	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	291						integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					GGAAGTTCTTCGCGGCAAAGA	0.507000													19	32					0	0	0.038395	0	0
RALGAPB	57148	broad.mit.edu	37	20	37146558	37146558	+	Silent	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr20:37146558G>A	ENST00000262879.6	+	9	1616	c.1332G>A	c.(1330-1332)ttG>ttA	p.L444L	RALGAPB_ENST00000397038.1_Silent_p.L222L|RALGAPB_ENST00000397042.3_Silent_p.L444L|RALGAPB_ENST00000537204.1_Silent_p.L444L|RALGAPB_ENST00000397040.1_Silent_p.L444L			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	444					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						ACAGCATCTTGAATCTCTTTG	0.453000													103	55					0	0	0.139131	0	0
DAO	1610	broad.mit.edu	37	12	109278891	109278891	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr12:109278891G>A	ENST00000228476.3	+	2	313	c.109G>A	c.(109-111)Gac>Aac	p.D37N	DAO_ENST00000551281.1_Missense_Mutation_p.D37N	NM_001917.4	NP_001908.3	P14920	OXDA_HUMAN	D-amino-acid oxidase	37					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|skin(1)	26						GGTCTACGCGGACCGCTTCAC	0.627000													43	52					0	0	0.139131	0	0
FPR2	2358	broad.mit.edu	37	19	52272840	52272840	+	Missense_Mutation	SNP	G	G	C	rs148745659	byFrequency	TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr19:52272840G>C	ENST00000598776.1	+	2	1701	c.929G>C	c.(928-930)cGa>cCa	p.R310P	FPR2_ENST00000340023.6_Missense_Mutation_p.R310P|FPR2_ENST00000598953.1_Missense_Mutation_p.R310P	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	310					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						CAAGACTTCCGAGAGAGACTG	0.542000													37	43					0	0	0.080422	0	0
SACS	26278	broad.mit.edu	37	13	23915199	23915199	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr13:23915199G>A	ENST00000382298.3	-	10	3404	c.2816C>T	c.(2815-2817)tCc>tTc	p.S939F	SACS_ENST00000382292.3_Missense_Mutation_p.S939F|SACS_ENST00000402364.1_Missense_Mutation_p.S189F	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	939					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGTATAAGAGGAAATTCCCTG	0.363000													66	41					0	0	0.139131	0	0
SPDL1	54908	broad.mit.edu	37	5	169028327	169028327	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr5:169028327C>T	ENST00000265295.4	+	11	1647	c.1368C>T	c.(1366-1368)ctC>ctT	p.L456L		NM_017785.4	NP_060255.3			spindle apparatus coiled-coil protein 1																		GTGAGGTGCTCCCTGTGGATA	0.443000													44	4					0	0	0.124865	0	0
NMBR	4829	broad.mit.edu	37	6	142396988	142396988	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr6:142396988G>A	ENST00000258042.1	-	3	1110	c.970C>T	c.(970-972)Ctt>Ttt	p.L324F	NMBR_ENST00000480652.1_5'UTR	NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	324					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		AGTAGGTAAAGAGCAAATGGG	0.458000													51	39					0	0	0.139131	0	0
KLHL23	151230	broad.mit.edu	37	2	170592455	170592455	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:170592455G>A	ENST00000392647.2	+	2	1175	c.931G>A	c.(931-933)Gag>Aag	p.E311K	KLHL23_ENST00000602521.1_Intron|KLHL23_ENST00000272797.4_Missense_Mutation_p.E311K	NM_144711.5	NP_653312.2	Q8NBE8	KLH23_HUMAN	kelch-like family member 23	311										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	16						TTATACCAGGGAGAGCTATGG	0.423000													60	69					0	0	0.139131	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137376	40137376	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:40137376C>T	ENST00000278198.2	-	2	2430	c.467G>A	c.(466-468)cGa>cAa	p.R156Q	LRRC4C_ENST00000530763.1_Missense_Mutation_p.R156Q|LRRC4C_ENST00000528697.1_Missense_Mutation_p.R156Q|LRRC4C_ENST00000527150.1_Missense_Mutation_p.R156Q			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	156					regulation of axonogenesis	integral to membrane	protein binding	p.R156Q(2)		NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GGGGTTGTTTCGCAACCAGAG	0.428000													21	53					0	0	0.062417	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332767	22332767	+	RNA	SNP	C	C	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr15:22332767C>A	ENST00000558896.1	+	0	574																											ACAGTTATGGCCTATGACAGG	0.502000													24	33					1.64293e-13	2.02089e-13	0.083992	1	0
NPVF	64111	broad.mit.edu	37	7	25266388	25266388	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr7:25266388C>T	ENST00000222674.2	-	2	442	c.396G>A	c.(394-396)ggG>ggA	p.G132G		NM_022150.3	NP_071433.3	Q9HCQ7	RFRP_HUMAN	neuropeptide VF precursor	132					neuropeptide signaling pathway	extracellular region|membrane	G-protein coupled receptor activity			cervix(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|urinary_tract(1)	15						TTGTTGTTCTCCCAAACCTTT	0.478000													188	83					0	0	0.139131	0	0
TMEM63C	57156	broad.mit.edu	37	14	77702977	77702977	+	Silent	SNP	C	C	T			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr14:77702977C>T	ENST00000298351.4	+	9	697	c.553C>T	c.(553-555)Ctg>Ttg	p.L185L		NM_020431.2	NP_065164.2	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	185						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(1)	23			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		GAGCAAGCTCCTGTGGCTGCA	0.582000													36	10					0	0	0.069456	0	0
SLC22A20	440044	broad.mit.edu	37	11	65003966	65003966	+	RNA	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:65003966G>A	ENST00000525437.1	+	0	1383							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						GTTTACCGGCGAGCTGTACCC	0.637000													7	12					0	0	0.038147	0	0
COL18A1	80781	broad.mit.edu	37	21	46895442	46895442	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr21:46895442A>G	ENST00000359759.4	+	4	2057	c.2036A>G	c.(2035-2037)gAg>gGg	p.E679G	COL18A1_ENST00000355480.5_Missense_Mutation_p.E444G|COL18A1_ENST00000400337.2_Missense_Mutation_p.E264G			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	679	Nonhelical region 1 (NC1).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CTTCTCAGGGAGGAGACGGTG	0.677000													5	2					0	0	0.014758	0	0
ORM1	5004	broad.mit.edu	37	9	117085950	117085950	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr9:117085950G>A	ENST00000538816.1	+	1	574	c.537G>A	c.(535-537)tgG>tgA	p.W179*	ORM1_ENST00000259396.8_Missense_Mutation_p.G41D			P02763	A1AG1_HUMAN	orosomucoid 1	0					acute-phase response|regulation of immune system process|transport	extracellular space	protein binding			endometrium(2)|large_intestine(4)|lung(2)	8		Myeloproliferative disorder(63;0.163)			Acenocoumarol(DB01418)|Alfentanil(DB00802)|Aprindine(DB01429)|Disopyramide(DB00280)|Penbutolol(DB01359)|Phenprocoumon(DB00946)|Quinidine(DB00908)|Tamsulosin(DB00706)	CAGATCACTGGCAAGTGGTTT	0.498000													40	54					0	0	0.111260	0	0
ANKRD23	200539	broad.mit.edu	37	2	97508103	97508105	+	Splice_Site	DEL	TTC	TTC	-			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:97508103_97508105delTTC	ENST00000318357.4	-	2	212_214	c.174_splice	c.e2+1	p.KK57_splice	ANKRD23_ENST00000418232.1_Splice_Site_p.KK57_splice|ANKRD23_ENST00000331001.2_Splice_Site_p.KK57_splice	NM_144994.7	NP_659431.5	Q86SG2	ANR23_HUMAN	ankyrin repeat domain 23	57				K -> N (in Ref. 6; CAC86120).		nucleus				endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)	9						CTCTCTCACTTTCTTCTTCTTCT	0.635													15	37	---	---	---	---					
NEB	4703	broad.mit.edu	37	2	152496526	152496526	+	Frame_Shift_Del	DEL	A	A	-	rs6713162	by1000genomes	TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr2:152496526delA	ENST00000427231.2	-	62	8936	c.8734delT	c.(8734-8736)ccfs	p.S2912fs	NEB_ENST00000409198.1_Frame_Shift_Del_p.S2912fs|NEB_ENST00000604864.1_Frame_Shift_Del_p.S2912fs|NEB_ENST00000172853.10_Frame_Shift_Del_p.S2912fs|NEB_ENST00000397345.3_Frame_Shift_Del_p.S2912fs|NEB_ENST00000603639.1_Frame_Shift_Del_p.S2912fs	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2912			S -> P (in dbSNP:rs6713162).		muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle	p.S2912P(1)		NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GAGCCAATGGACACCCAGCCA	0.393													38	74	---	---	---	---					
MRAS	22808	broad.mit.edu	37	3	138121035	138121037	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr3:138121035_138121037delAGA	ENST00000289104.4	+	6	1198_1200	c.551_553delAGA	c.(550-555)cag>c	p.QK184del	MRAS_ENST00000423968.2_In_Frame_Del_p.QK184del|MRAS_ENST00000474559.1_In_Frame_Del_p.QK184del|MRAS_ENST00000464896.1_In_Frame_Del_p.QK108del	NM_001085049.2|NM_001252090.1|NM_001252091.1|NM_012219.4	NP_001078518.1|NP_001239019.1|NP_001239020.1|NP_036351.3	O14807	RASM_HUMAN	muscle RAS oncogene homolog	184					actin cytoskeleton organization|muscle organ development|Ras protein signal transduction	intracellular|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity			kidney(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	14						GAAAAAAGCCAGAAGAAGAAGAA	0.522													7	542	---	---	---	---					
IPO11	51194	broad.mit.edu	37	5	61763066	61763069	+	Frame_Shift_Del	DEL	GAAC	GAAC	-			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr5:61763066_61763069delGAAC	ENST00000325324.6	+	6	794_797	c.625_628delGAAC	c.(625-630)gafs	p.ER209fs	KIF2A_ENST00000509663.2_Intron|IPO11_ENST00000409296.3_Frame_Shift_Del_p.ER249fs	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	209						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		GAGTTCACTAGAACGAACACTGCT	0.377													20	84	---	---	---	---					
BHLHE22	27319	broad.mit.edu	37	8	65494021	65494023	+	In_Frame_Del	DEL	GCA	GCA	-	rs62519837		TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr8:65494021_65494023delGCA	ENST00000321870.1	+	1	1208_1210	c.674_676delGCA	c.(673-678)ggc>g	p.GS225del	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	225	Gly-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.S234delS(1)|p.S226G(1)		NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						ggcagcggcggcagcagcagcag	0.709													2	4	---	---	---	---					
CUL5	8065	broad.mit.edu	37	11	107965175	107965176	+	In_Frame_Ins	INS	-	-	AAGTATCTG			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr11:107965175_107965176insAAGTATCTG	ENST00000393094.2	+	14	2117_2118	c.1501_1502insAAGTATCTG	c.(1501-1503)agt>AAGTATCTGagt	p.500_501insKYL		NM_003478.3	NP_003469.2	Q93034	CUL5_HUMAN	cullin 5	500					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		TCAGGACATAAAAGTATCTGAA	0.277													16	21	---	---	---	---					
PKMYT1	9088	broad.mit.edu	37	16	3023032	3023033	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr16:3023032_3023033delCT	ENST00000262300.8	-	9	1929_1930	c.1421_1422delAG	c.(1420-1422)gfs	p.E474fs	PAQR4_ENST00000572687.1_3'UTR|PKMYT1_ENST00000574385.1_Frame_Shift_Del_p.E465fs|PAQR4_ENST00000318782.8_3'UTR|PAQR4_ENST00000293978.8_3'UTR|PKMYT1_ENST00000431515.2_Intron|PKMYT1_ENST00000574730.1_Frame_Shift_Del_p.E405fs|PKMYT1_ENST00000440027.2_3'UTR|PKMYT1_ENST00000573944.1_Frame_Shift_Del_p.E465fs	NM_001258450.1|NM_004203.4|NM_182687.2	NP_001245379.1|NP_004194.3|NP_872629.1	Q99640	PMYT1_HUMAN	protein kinase, membrane associated tyrosine/threonine 1	474	Interaction with CDC2-CCNB1.|Interaction with PIN1.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	10						CCCGAGGAGGCTCTGAGTTGAT	0.609													27	26	---	---	---	---					
NOL4	8715	broad.mit.edu	37	18	31538307	31538307	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr18:31538307delG	ENST00000261592.5	-	7	1429	c.1132delC	c.(1132-1134)tafs	p.L378fs	NOL4_ENST00000589544.1_Frame_Shift_Del_p.L378fs|NOL4_ENST00000535384.1_Frame_Shift_Del_p.L93fs|NOL4_ENST00000535475.1_Frame_Shift_Del_p.L223fs|NOL4_ENST00000269185.4_Frame_Shift_Del_p.L264fs|NOL4_ENST00000538587.1_Frame_Shift_Del_p.L304fs	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	378						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						CCCCTGTTTAGTGAGAGGTCC	0.488													102	155	---	---	---	---					
SREBF2	6721	broad.mit.edu	37	22	42262949	42262951	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FS-A1ZE-06A-11D-A197-08	TCGA-FS-A1ZE-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8bc90571-61b8-4672-91f8-ed87c1a4a1ab	28e16dcc-e820-4e52-a0dd-a6289195da53	g.chr22:42262949_42262951delGCA	ENST00000361204.4	+	2	369_371	c.203_205delGCA	c.(202-207)ggc>g	p.GS68del		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	68	Gly/Pro/Ser-rich.				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						ggcagcagtggcagcagcagcag	0.567													8	210	---	---	---	---					
