Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
COL28A1	340267	broad.mit.edu	37	7	7483255	7483255	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:7483255G>A	ENST00000399429.3	-	20	1751	c.1611C>T	c.(1609-1611)ggC>ggT	p.G537G		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	537	Collagen-like 4.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GTCCTTCTGGGCCTCTTGCTC	0.542000													15	19					0	0	1	0	0
RAPGEFL1	51195	broad.mit.edu	37	17	38349179	38349179	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:38349179C>T	ENST00000436615.3	+	13	1618	c.1126_splice	c.e13-1	p.D376_splice	RAPGEFL1_ENST00000264644.6_Splice_Site_p.D376_splice|RAPGEFL1_ENST00000456989.2_Splice_Site_p.D431_splice|RAPGEFL1_ENST00000544503.1_Splice_Site_p.D425_splice	NM_016339.3	NP_057423.1	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor (GEF)-like 1	582					G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)	15						ATCCCCTAGACCTGACTTTCC	0.542000													25	47					0	0	1	0	0
IL17RD	54756	broad.mit.edu	37	3	57143616	57143616	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:57143616G>A	ENST00000296318.7	-	5	587	c.499C>T	c.(499-501)Cct>Tct	p.P167S	IL17RD_ENST00000463523.1_Missense_Mutation_p.P23S|IL17RD_ENST00000427856.2_Missense_Mutation_p.P143S|IL17RD_ENST00000320057.5_Missense_Mutation_p.P23S	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	167						Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		TTAATGGAAGGAAAAGGGACA	0.408000													22	25					0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200233369	200233369	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:200233369T>G	ENST00000443023.1	-	5	1947	c.482A>C	c.(481-483)cAg>cCg	p.Q161P	SATB2_ENST00000260926.5_Missense_Mutation_p.Q220P|SATB2_ENST00000484124.1_5'UTR|SATB2_ENST00000417098.1_Missense_Mutation_p.Q220P|SATB2_ENST00000428695.1_Intron|SATB2_ENST00000457245.1_Missense_Mutation_p.Q220P			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	220						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CCCAAACTCCTGGCACTTGGT	0.313000													11	14					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223285778	223285778	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:223285778G>A	ENST00000540964.1	-	4	1057	c.596C>T	c.(595-597)tCc>tTc	p.S199F	TLR5_ENST00000342210.6_Missense_Mutation_p.S199F			O60602	TLR5_HUMAN	toll-like receptor 5	199					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		GCTAAAAAAGGAGAGCGTTTT	0.423000													25	27					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655285	19655285	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:19655285C>T	ENST00000586018.1	+	8	2051	c.1949C>T	c.(1948-1950)tCc>tTc	p.S650F	CILP2_ENST00000291495.4_Missense_Mutation_p.S644F			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	644						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GGCATGTTCTCCGTGGACCTC	0.726000													42	32					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38951170	38951170	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:38951170T>C	ENST00000355481.4	+	20	2647	c.2516T>C	c.(2515-2517)gTg>gCg	p.V839A	RYR1_ENST00000360985.3_Missense_Mutation_p.V839A|RYR1_ENST00000359596.3_Missense_Mutation_p.V839A	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	839					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCTCACCTGGTGGGCCCCAGT	0.642000													44	44					0	0	1	0	0
SLC1A1	6505	broad.mit.edu	37	9	4572296	4572296	+	Silent	SNP	C	C	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr9:4572296C>G	ENST00000262352.3	+	7	911	c.675C>G	c.(673-675)gtC>gtG	p.V225V		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	225					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	TTGGACTTGTCATTGGAAAAA	0.398000													103	10					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170031891	170031891	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:170031891G>A	ENST00000263816.3	-	55	10865	c.10580C>T	c.(10579-10581)cCt>cTt	p.P3527L		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3527	LDL-receptor class A 26.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCACCAGATAGGAATGCACCT	0.498000													9	23					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18025417	18025417	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:18025417C>T	ENST00000205890.5	+	2	3641	c.3303C>T	c.(3301-3303)ccC>ccT	p.P1101P		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1101	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					AGCCCCTGCCCAAGGGGGGTG	0.682000													35	61					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10914373	10914373	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr21:10914373C>T	ENST00000298232.7	-	20	1659	c.1292G>A	c.(1291-1293)gGa>gAa	p.G431E	TPTE_ENST00000361285.4_Missense_Mutation_p.G449E|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.G411E	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	449	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CGAACATTTTCCTAATGAAAT	0.318000													5	24					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80329072	80329072	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr4:80329072C>T	ENST00000358842.3	-	1	300	c.283G>A	c.(283-285)Gaa>Aaa	p.E95K		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	95					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						ACAGTGGTTTCCCTCTGATTG	0.428000													34	43					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7168079	7168079	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:7168079A>G	ENST00000341500.5	-	7	1549	c.1510T>C	c.(1510-1512)Tac>Cac	p.Y504H	INSR_ENST00000302850.5_Missense_Mutation_p.Y504H	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	504					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GTCCGAATGTAAGAAAATTTA	0.448000													19	11					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53577633	53577633	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:53577633T>C	ENST00000342160.3	-	65	9939	c.9482A>G	c.(9481-9483)cAt>cGt	p.H3161R	HUWE1_ENST00000262854.6_Missense_Mutation_p.H3161R			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3161					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GTACCTGTTATGGCTGCTGCT	0.498000													11	10					0	0	1	0	0
ASCL1	429	broad.mit.edu	37	12	103352363	103352363	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:103352363A>T	ENST00000266744.3	+	1	900	c.341A>T	c.(340-342)cAg>cTg	p.Q114L		NM_004316.3	NP_004307.2	P50553	ASCL1_HUMAN	achaete-scute family bHLH transcription factor 1	114					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			NS(3)|large_intestine(1)|lung(1)	5						AGCCTGCCGCAGCAGCAGCCG	0.667000													10	2					0	0	1	0	0
LMAN1	3998	broad.mit.edu	37	18	57016392	57016392	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr18:57016392G>A	ENST00000251047.5	-	6	1433	c.716C>T	c.(715-717)cCt>cTt	p.P239L	LMAN1_ENST00000587940.1_5'UTR	NM_005570.3	NP_005561.1	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1	239	L-type lectin-like.				blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	CCCTTGTGCAGGGATAATCAT	0.353000													22	27					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34763552	34763552	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr20:34763552C>T	ENST00000338074.2	+	3	418	c.257C>T	c.(256-258)tCg>tTg	p.S86L	EPB41L1_ENST00000202028.5_Missense_Mutation_p.S24L|EPB41L1_ENST00000373946.3_Missense_Mutation_p.S55L|EPB41L1_ENST00000441639.1_Missense_Mutation_p.S24L|EPB41L1_ENST00000373941.1_Missense_Mutation_p.S86L|EPB41L1_ENST00000373950.2_Missense_Mutation_p.S24L	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	86					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					GCCCAGAAATCGCCCCAGAAG	0.567000													17	24					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49063829	49063829	+	Splice_Site	SNP	A	A	C			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr4:49063829A>C	ENST00000226432.4	+	16	2205	c.2021_splice	c.e16-1	p.R674_splice	CWH43_ENST00000513409.1_Splice_Site_p.R647_splice	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	674					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						atttttttaGATTTGGATCCT	0.229000													3	5					0	0	1	0	0
PVRL4	81607	broad.mit.edu	37	1	161044465	161044465	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:161044465G>A	ENST00000368012.3	-	5	1238	c.936C>T	c.(934-936)atC>atT	p.I312I	PVRL4_ENST00000453926.2_Silent_p.I46I	NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	312	Ig-like C2-type 2.				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			GGCAGACGTAGATGCCGCTGT	0.562000													11	25					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14647077	14647077	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:14647077C>T	ENST00000403951.2	-	17	1837	c.1418G>A	c.(1417-1419)gGa>gAa	p.G473E	DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000402815.1_Missense_Mutation_p.G472E|DGKB_ENST00000444700.2_Missense_Mutation_p.G454E|DGKB_ENST00000399322.3_Missense_Mutation_p.G473E|DGKB_ENST00000258767.5_Missense_Mutation_p.G473E|DGKB_ENST00000407950.1_Missense_Mutation_p.G465E|DGKB_ENST00000406247.3_Missense_Mutation_p.G473E			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	473	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TGGTCCATTTCCAGAAAGACT	0.294000													10	10					0	0	1	0	0
SEC14L3	266629	broad.mit.edu	37	22	30866012	30866012	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr22:30866012G>A	ENST00000403066.1	-	5	334	c.51C>T	c.(49-51)ccC>ccT	p.P17P	SEC14L3_ENST00000540910.1_5'UTR|SEC14L3_ENST00000415957.2_Silent_p.P17P|SEC14L3_ENST00000215812.4_Silent_p.P76P|SEC14L3_ENST00000402286.1_5'UTR|SEC14L3_ENST00000401751.1_Silent_p.P17P|SEC14L3_ENST00000539629.1_Silent_p.P17P			Q9UDX4	S14L3_HUMAN	SEC14-like 3 (S. cerevisiae)	76						integral to membrane|intracellular	lipid binding|transporter activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	19					Vitamin E(DB00163)	TCACCTCTGGGGGCTGCCAAT	0.552000													48	75					0	0	1	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27888056	27888056	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:27888056G>T	ENST00000326019.6	+	2	1197	c.915G>T	c.(913-915)aaG>aaT	p.K305N		NM_018158.2	NP_060628.2	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger), member 1, adaptor protein	305						cytoplasm|nucleus	double-stranded RNA binding|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.155)					TGTTGGAGAAGAAGATGCTAG	0.463000													31	52					1.7881e-09	1.7948e-09	1	1	0
NRG3	10718	broad.mit.edu	37	10	84738847	84738847	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr10:84738847C>T	ENST00000372142.2	+	9	1165	c.891C>T	c.(889-891)atC>atT	p.I297I	NRG3_ENST00000545131.1_Silent_p.I168I|NRG3_ENST00000404547.1_Silent_p.I518I|NRG3_ENST00000404576.2_Silent_p.I322I|NRG3_ENST00000537893.1_Silent_p.I168I|NRG3_ENST00000372141.2_Silent_p.I518I|NRG3_ENST00000556918.1_Silent_p.I348I	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	518	EGF-like.				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AATCAAGGATCCCAGACCAGG	0.473000													9	0					0	0	1	0	0
MIR519E	574463	broad.mit.edu	37	19	54183195	54183195	+	RNA	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:54183195C>T	ENST00000385075.1	+	0	2					NR_030185.1																						GCGAGAAGATCTCATGCAGTC	0.383000													11	24					0	0	1	0	0
PGAP3	93210	broad.mit.edu	37	17	37840880	37840880	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:37840880G>A	ENST00000300658.4	-	3	494	c.402C>T	c.(400-402)ccC>ccT	p.P134P	PGAP3_ENST00000579146.1_Silent_p.P134P|PGAP3_ENST00000378011.4_Intron|PGAP3_ENST00000429199.2_Silent_p.P134P	NM_033419.3	NP_219487.3	Q96FM1	PGAP3_HUMAN	post-GPI attachment to proteins 3	134					GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12						TGTGGTACATGGGGGAGGAGG	0.587000													14	26					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243328992	243328992	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:243328992G>A	ENST00000366542.1	-	13	2321	c.2270C>T	c.(2269-2271)gCt>gTt	p.A757V	CEP170_ENST00000366544.1_Missense_Mutation_p.A659V|RP11-261C10.4_ENST00000422938.1_RNA|RP11-261C10.4_ENST00000437499.1_RNA|CEP170_ENST00000366543.1_Missense_Mutation_p.A659V	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	757						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TGTCCACTGAGCCTCCTCCCT	0.378000													21	98					0	0	1	0	0
KRT6B	3854	broad.mit.edu	37	12	52844240	52844240	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:52844240C>T	ENST00000252252.3	-	2	752	c.705G>A	c.(703-705)ctG>ctA	p.L235L		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	235	Coil 1B.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		GCTCCGAGTCCAGACGACCCC	0.552000													56	89					0	0	1	0	0
PMP2	5375	broad.mit.edu	37	8	82357090	82357090	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:82357090C>T	ENST00000256103.2	-	2	344	c.208G>A	c.(208-210)Gaa>Aaa	p.E70K	RP11-157I4.4_ENST00000524085.2_RNA|PMP2_ENST00000519260.1_Intron	NM_002677.3	NP_002668.1	P02689	MYP2_HUMAN	peripheral myelin protein 2	70						cytoplasm	cholesterol binding|fatty acid binding|transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			Epithelial(68;0.186)			TCTTCAAATTCCTGGCCTAGC	0.398000													63	23					0	0	1	0	0
TAS2R38	5726	broad.mit.edu	37	7	141672668	141672668	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:141672668G>A	ENST00000547270.1	-	1	905	c.822C>T	c.(820-822)cgC>cgT	p.R274R		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	274					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					CTATTTTGTCGCGCCACAGAA	0.502000													5	36					0	0	1	0	0
CA1	759	broad.mit.edu	37	8	86240815	86240815	+	Missense_Mutation	SNP	C	C	T	rs121909577		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:86240815C>T	ENST00000523953.1	-	9	1806	c.760G>A	c.(760-762)Ggc>Agc	p.G254S	CA1_ENST00000256119.5_Missense_Mutation_p.G254S|CA1_ENST00000432364.2_Missense_Mutation_p.G254S|CA1_ENST00000522389.1_Missense_Mutation_p.G120S|CA1_ENST00000523022.1_Missense_Mutation_p.G254S|CA1_ENST00000542576.1_Missense_Mutation_p.G254S|CA1_ENST00000431316.1_Missense_Mutation_p.G254S			P00915	CAH1_HUMAN	carbonic anhydrase I	254			G -> R (in Guam).		one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	13		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	ACTGTTCTGCCCTTCAGAGGT	0.448000													77	28					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115217462	115217462	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:115217462G>A	ENST00000369538.3	-	12	1845	c.1798C>T	c.(1798-1800)Cct>Tct	p.P600S	AMPD1_ENST00000520113.2_Missense_Mutation_p.P604S|AMPD1_ENST00000353928.6_Missense_Mutation_p.P571S	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	571					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	CCACAGTGAGGTCGGAACAGA	0.443000													18	20					0	0	1	0	0
OR10A5	144124	broad.mit.edu	37	11	6867321	6867321	+	Silent	SNP	C	C	T	rs139750997	byFrequency	TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr11:6867321C>T	ENST00000299454.4	+	1	439	c.408C>T	c.(406-408)atC>atT	p.I136I	OR10A5_ENST00000379831.2_Silent_p.I140I			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ACCCAGTCATCATGAACCAAA	0.512000													51	24					0	0	1	0	0
SLC25A12	8604	broad.mit.edu	37	2	172683359	172683359	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:172683359G>A	ENST00000422440.2	-	9	916	c.879C>T	c.(877-879)gcC>gcT	p.A293A	SLC25A12_ENST00000392592.4_Silent_p.A186A	NM_003705.4	NP_003696.2	O75746	CMC1_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 12	293					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|upper_aerodigestive_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	CAGCCAATGGGGCTATTCTCT	0.408000													15	11					0	0	1	0	0
CER1	9350	broad.mit.edu	37	9	14722348	14722348	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr9:14722348C>T	ENST00000380911.3	-	1	367	c.323G>A	c.(322-324)gGg>gAg	p.G108E		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	108					BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		GGACTGGGTCCCAGGTGGGAA	0.493000													19	6					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115217461	115217461	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:115217461G>A	ENST00000369538.3	-	12	1846	c.1799C>T	c.(1798-1800)cCt>cTt	p.P600L	AMPD1_ENST00000520113.2_Missense_Mutation_p.P604L|AMPD1_ENST00000353928.6_Missense_Mutation_p.P571L	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	571					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TCCACAGTGAGGTCGGAACAG	0.448000													19	21					0	0	1	0	0
C2orf43	60526	broad.mit.edu	37	2	20939959	20939959	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:20939959G>A	ENST00000237822.3	-	5	554	c.475C>T	c.(475-477)Cgt>Tgt	p.R159C	C2orf43_ENST00000541941.1_Missense_Mutation_p.R29C|C2orf43_ENST00000403006.2_Missense_Mutation_p.R29C|C2orf43_ENST00000381090.3_Missense_Mutation_p.R159C|C2orf43_ENST00000435420.2_Missense_Mutation_p.R111C|C2orf43_ENST00000440866.2_Intron	NM_021925.2	NP_068744.1	Q9H6V9	CB043_HUMAN	chromosome 2 open reading frame 43	159										endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGAAAGGCACGAATTACCTGC	0.383000													13	19					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286261	48286261	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr11:48286261G>A	ENST00000320048.1	+	1	849	c.849G>A	c.(847-849)gtG>gtA	p.V283V		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						TAAACCCTGTGATTTACTCCT	0.408000													7	30					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141874461	141874461	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:141874461G>A	ENST00000522684.1	-	5	629	c.400C>T	c.(400-402)Cta>Tta	p.L134L	PTK2_ENST00000517887.1_Silent_p.L178L|PTK2_ENST00000535192.1_Silent_p.L134L|PTK2_ENST00000340930.3_Silent_p.L134L|PTK2_ENST00000395218.2_Silent_p.L134L|PTK2_ENST00000521059.1_Silent_p.L134L|PTK2_ENST00000519419.1_Silent_p.L178L	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	134	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			AACTGGTTTAGAAATCCTTTT	0.284000													53	22					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36270060	36270060	+	Silent	SNP	T	T	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr5:36270060T>G	ENST00000296604.3	-	3	668	c.183A>C	c.(181-183)gcA>gcC	p.A61A	RANBP3L_ENST00000515759.1_Silent_p.A61A|RANBP3L_ENST00000502994.1_Silent_p.A61A	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	61					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TACCTGGTTCTGCTGCTTCAT	0.383000													41	6					0	0	1	0	0
UBASH3A	53347	broad.mit.edu	37	21	43862610	43862610	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr21:43862610T>G	ENST00000319294.6	+	12	1566	c.1535T>G	c.(1534-1536)tTt>tGt	p.F512C	UBASH3A_ENST00000291535.6_Missense_Mutation_p.F474C|UBASH3A_ENST00000398367.1_Missense_Mutation_p.F474C	NM_018961.3	NP_061834.1	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing A	512	Phosphatase-like.					cytosol|nucleus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(9)|lung(12)|ovary(3)	28						CCTGGAATCTTTGAATGGACA	0.418000													33	30					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117758535	117758535	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:117758535C>T	ENST00000276204.6	+	32	3579	c.3505C>T	c.(3505-3507)Ccc>Tcc	p.P1169S	DOCK11_ENST00000276202.7_Missense_Mutation_p.P1169S			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1169					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						ATTGTACCTCCCCTTTGTTGG	0.333000													67	105					0	0	1	0	0
IL1F10	84639	broad.mit.edu	37	2	113832386	113832386	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:113832386G>A	ENST00000393197.2	+	3	626	c.205G>A	c.(205-207)Gca>Aca	p.A69T	IL1F10_ENST00000341010.2_Missense_Mutation_p.A69T|IL1F10_ENST00000337569.3_Missense_Mutation_p.A69T	NM_032556.5	NP_115945.4	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10 (theta)	69						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			endometrium(1)|lung(6)|ovary(1)	8						CCGCTGCCTGGCATGTGTGGA	0.607000													23	28					0	0	1	0	0
UPP1	7378	broad.mit.edu	37	7	48139293	48139293	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:48139293C>T	ENST00000331803.4	+	5	694	c.71C>T	c.(70-72)cCa>cTa	p.P24L	UPP1_ENST00000429491.2_Intron|UPP1_ENST00000395564.4_Missense_Mutation_p.P24L|UPP1_ENST00000482015.1_Intron|UPP1_ENST00000341253.4_Missense_Mutation_p.P24L			Q16831	UPP1_HUMAN	uridine phosphorylase 1	24					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	18						CTTTTAAATCCAAACATAGCA	0.413000													18	35					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170967454	170967454	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:170967454C>T	ENST00000367758.3	+	15	1734	c.1635C>T	c.(1633-1635)ttC>ttT	p.F545F	MROH9_ENST00000367759.4_Intron	NM_025063.2	NP_079339.2			maestro heat-like repeat family member 9																		GTTCTCATTTCCTTTTCTTAC	0.373000													10	27					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120007788	120007788	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:120007788C>T	ENST00000371311.3	-	2	1116	c.862G>A	c.(862-864)Gat>Aat	p.D288N		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	288										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						TTTTCCACATCCTTCTCTTTT	0.448000													292	348					0	0	1	0	0
OR2W3	343171	broad.mit.edu	37	1	248059147	248059147	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:248059147G>A	ENST00000537741.1	+	3	516	c.259G>A	c.(259-261)Gga>Aga	p.G87R	OR2W3_ENST00000360358.3_Missense_Mutation_p.G87R			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CAACCTTAATGGATGTGACAA	0.567000													41	60					0	0	1	0	0
ADAT2	134637	broad.mit.edu	37	6	143759801	143759801	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr6:143759801G>A	ENST00000237283.8	-	2	141	c.127C>T	c.(127-129)Cct>Tct	p.P43S	ADAT2_ENST00000606514.1_5'UTR|AL031320.1_ENST00000595616.1_Intron	NM_182503.2	NP_872309.2	Q7Z6V5	ADAT2_HUMAN	adenosine deaminase, tRNA-specific 2	43					tRNA processing		hydrolase activity|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)	8				OV - Ovarian serous cystadenocarcinoma(155;5.61e-06)|GBM - Glioblastoma multiforme(68;0.0115)		CAGCCAACAGGAACTTCAGTA	0.388000													25	2					0	0	1	0	0
FABP2	2169	broad.mit.edu	37	4	120241839	120241839	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr4:120241839C>T	ENST00000274024.3	-	2	513	c.226G>A	c.(226-228)Gga>Aga	p.G76R		NM_000134.3	NP_000125.2	P12104	FABPI_HUMAN	fatty acid binding protein 2, intestinal	76							fatty acid binding			breast(1)|large_intestine(4)|lung(1)|ovary(1)|pancreas(1)	8						AGTTCAGTTCCGTCTGCTAGA	0.318000													14	23					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25326484	25326484	+	RNA	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:25326484G>A	ENST00000546682.1	+	0	71				SNORD116-15_ENST00000384445.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TGAACAAAATGAGTGAAAACT	0.448000													44	52					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039406	11039406	+	RNA	SNP	T	T	C	rs8134740	by1000genomes	TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr21:11039406T>C	ENST00000470054.1	-	0	797									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCATTAGAAATCTGTTTTTCC	0.299000													7	113					0	0	1	0	0
TBX19	9095	broad.mit.edu	37	1	168274383	168274383	+	Silent	SNP	C	C	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:168274383C>A	ENST00000367821.3	+	6	916	c.865C>A	c.(865-867)Cgg>Agg	p.R289R		NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	289					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					CCGAGGACACCGGCAGGCTCC	0.587000													40	41					4.07013e-28	4.14751e-28	1	1	0
TRAK2	66008	broad.mit.edu	37	2	202245723	202245723	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:202245723G>A	ENST00000332624.3	-	16	2716	c.2288C>T	c.(2287-2289)cCc>cTc	p.P763L		NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	763				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						AGGCTGGAGGGGGTTCTCTGA	0.517000													52	46					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36495408	36495408	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:36495408C>T	ENST00000342292.4	-	2	815	c.794_splice	c.e2-1	p.R265_splice		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	265						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GCACCTGCCCCCTACGGCAGT	0.527000													19	14					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141130635	141130635	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:141130635C>T	ENST00000389484.3	-	69	11681	c.10710G>A	c.(10708-10710)tgG>tgA	p.W3570*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3570	LDL-receptor class A 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATCACATTTCCATTTTGCTG	0.358000										TSP Lung(27;0.18)			30	43					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66948194	66948194	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr16:66948194C>T	ENST00000299752.4	-	7	898	c.705G>A	c.(703-705)gaG>gaA	p.E235E	CDH16_ENST00000570262.1_Silent_p.E155E|CDH16_ENST00000565796.1_Silent_p.E235E|CDH16_ENST00000394055.3_Silent_p.E235E|CDH16_ENST00000568632.1_Silent_p.E138E	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	235	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CCCAGGTGCTCTCTATGATGG	0.587000													32	37					0	0	1	0	0
SLC25A18	83733	broad.mit.edu	37	22	18072870	18072870	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr22:18072870G>A	ENST00000327451.5	+	11	1354	c.816G>A	c.(814-816)tgG>tgA	p.W272*	SLC25A18_ENST00000399813.1_Nonsense_Mutation_p.W272*	NM_031481.1	NP_113669.1	Q9H1K4	GHC2_HUMAN	solute carrier family 25 (glutamate carrier), member 18	272						integral to membrane|mitochondrial inner membrane	binding|symporter activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	18				Lung(27;0.124)	L-Glutamic Acid(DB00142)	GGAAACTCTGGATTCAGGAGG	0.547000													16	33					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24426248	24426248	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:24426248C>T	ENST00000330966.7	-	6	743	c.581G>A	c.(580-582)cGg>cAg	p.R194Q	MYOM3_ENST00000329601.7_Missense_Mutation_p.R193Q|MYOM3_ENST00000374434.3_Missense_Mutation_p.R193Q|MYOM3_ENST00000475306.1_5'UTR			Q5VTT5	MYOM3_HUMAN	myomesin 3	193	Ig-like C2-type 1.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GGGATCAATCCGTGTGTCATT	0.572000													28	18					0	0	1	0	0
CACNG2	10369	broad.mit.edu	37	22	36962426	36962426	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr22:36962426C>T	ENST00000300105.6	-	3	1391	c.410G>A	c.(409-411)aGt>aAt	p.S137N		NM_006078.3	NP_006069.1	Q9Y698	CCG2_HUMAN	calcium channel, voltage-dependent, gamma subunit 2	137					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	18						GATGCCGGCACTCAGGATGAT	0.562000													21	29					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186077644	186077644	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:186077644G>A	ENST00000271588.4	+	71	11133	c.10904G>A	c.(10903-10905)cGg>cAg	p.R3635Q	HMCN1_ENST00000367492.2_Missense_Mutation_p.R3635Q	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3635	Ig-like C2-type 35.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ACTGTGTTACGGAACAGACAA	0.418000													15	18					0	0	1	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74648947	74648947	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:74648947G>A	ENST00000541184.1	-	6	1019	c.542C>T	c.(541-543)aCg>aTg	p.T181M	ZDHHC15_ENST00000373367.3_Missense_Mutation_p.T190M|ZDHHC15_ENST00000373361.3_Intron	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	190						integral to membrane	zinc ion binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						GAAGACTGTCGTAGCAATGTA	0.373000													12	16					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24257733	24257733	+	Silent	SNP	G	G	C			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:24257733G>C	ENST00000538205.1	+	12	1372	c.825G>C	c.(823-825)ctG>ctC	p.L275L	RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000256412.4_Silent_p.L354L|RP11-624C23.1_ENST00000519689.1_RNA|ADAMDEC1_ENST00000522298.1_Silent_p.L275L	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	354	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CACATGAGCTGGGCCATGTCC	0.388000													9	19					0	0	1	0	0
CD276	80381	broad.mit.edu	37	15	73995154	73995154	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:73995154G>A	ENST00000318443.5	+	4	762	c.460G>A	c.(460-462)Gac>Aac	p.D154N	CD276_ENST00000564751.1_Intron|CD276_ENST00000561213.1_Missense_Mutation_p.D154N|CD276_ENST00000318424.5_Intron|CD276_ENST00000537340.2_Missense_Mutation_p.D8N	NM_001024736.1	NP_001019907.1	Q5ZPR3	CD276_HUMAN	CD276 molecule	154	Ig-like C2-type 1.				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			endometrium(3)|lung(5)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	13						GCCCAACAAGGACCTGCGGCC	0.637000													9	14					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120833	38120833	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr22:38120833C>T	ENST00000406386.3	+	7	2525	c.2270C>T	c.(2269-2271)tCc>tTc	p.S757F	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	757					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CCCAGAGCCTCCTCTCCTAAC	0.567000													27	36					0	0	1	0	0
MTERFD1	51001	broad.mit.edu	37	8	97258585	97258585	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:97258585C>T	ENST00000523821.1	-	5	894	c.775G>A	c.(775-777)Gat>Aat	p.D259N	MTERFD1_ENST00000522822.1_Missense_Mutation_p.D138N|MTERFD1_ENST00000287025.3_Missense_Mutation_p.D259N|MTERFD1_ENST00000524341.1_Missense_Mutation_p.D69N			Q96E29	MTER1_HUMAN	MTERF domain containing 1	259					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	24	Breast(36;5.16e-05)					AATCTGTTATCCAGTCTTTCC	0.348000													31	15					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25470195	25470195	+	RNA	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:25470195C>T	ENST00000453082.2	+	0	963					NR_003343.1																						GCGTTGGGCCCAAAGGCCCTA	0.577000													9	12					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46979124	46979124	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr4:46979124C>T	ENST00000264318.3	-	5	1513	c.531G>A	c.(529-531)gtG>gtA	p.V177V		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	177					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.V177V(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGGGAAAATCCACCAATCTCA	0.338000													5	14					0	0	1	0	0
SLC1A1	6505	broad.mit.edu	37	9	4572341	4572341	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr9:4572341C>G	ENST00000262352.3	+	7	956	c.720C>G	c.(718-720)ttC>ttG	p.F240L		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	240					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	TGGATTTCTTCAATGCTTTGA	0.418000													87	9					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101510497	101510497	+	Nonsense_Mutation	SNP	C	C	T	rs145182702		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:101510497C>T	ENST00000392979.3	+	24	2747	c.2386C>T	c.(2386-2388)Cga>Tga	p.R796*	ANO4_ENST00000299222.9_Nonsense_Mutation_p.R351*|ANO4_ENST00000392977.3_Nonsense_Mutation_p.R831*|ANO4_ENST00000550015.1_Nonsense_Mutation_p.R351*	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	831						chloride channel complex	chloride channel activity	p.R796*(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GTCTGTATTTCGAATTTCTGA	0.483000										HNSCC(74;0.22)			41	9					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14836145	14836145	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:14836145C>T	ENST00000261170.3	-	4	578	c.442G>A	c.(442-444)Gga>Aga	p.G148R	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	148					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CATGACAATCCAAAACTTCCA	0.403000													12	13					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	93315	93315	+	Silent	SNP	A	A	G	rs9794100		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr10:93315A>G	ENST00000447903.2	-	4	1116	c.801T>C	c.(799-801)agT>agC	p.S267S	TUBB8_ENST00000309812.4_Silent_p.S339S			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	339					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity	p.S339S(1)		NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		CAGCAAAGTAACTGCTGTTCT	0.517000													4	125					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58109342	58109342	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:58109342C>T	ENST00000357272.4	+	21	3814	c.3649C>T	c.(3649-3651)Ccc>Tcc	p.P1217S	FLNB_ENST00000419752.2_Missense_Mutation_p.P1048S|FLNB_ENST00000429972.2_Missense_Mutation_p.P1217S|FLNB_ENST00000295956.4_Missense_Mutation_p.P1217S|FLNB_ENST00000490882.1_Missense_Mutation_p.P1217S|FLNB_ENST00000358537.3_Missense_Mutation_p.P1217S|FLNB_ENST00000348383.5_Missense_Mutation_p.P1217S|FLNB_ENST00000493452.1_Missense_Mutation_p.P1048S			O75369	FLNB_HUMAN	filamin B, beta	1217	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GCCACACTTCCCCGCCCGGGT	0.537000													22	31					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158281253	158281253	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr4:158281253C>T	ENST00000296526.7	+	13	2574	c.2249C>T	c.(2248-2250)tCc>tTc	p.S750F	GRIA2_ENST00000264426.9_Missense_Mutation_p.S750F|GRIA2_ENST00000507898.1_Missense_Mutation_p.S703F|GRIA2_ENST00000393815.2_Missense_Mutation_p.S703F|GRIA2_ENST00000449365.1_Missense_Mutation_p.S703F	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	750					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AACCTGGATTCCAAAGGCTAT	0.438000													15	18					0	0	1	0	0
LMAN1	3998	broad.mit.edu	37	18	57016393	57016393	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr18:57016393G>T	ENST00000251047.5	-	6	1432	c.715C>A	c.(715-717)Cct>Act	p.P239T	LMAN1_ENST00000587940.1_5'UTR	NM_005570.3	NP_005561.1	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1	239	L-type lectin-like.				blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	CCTTGTGCAGGGATAATCATA	0.353000													22	28					8.04996e-18	8.17193e-18	1	1	0
DMXL2	23312	broad.mit.edu	37	15	51763533	51763533	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:51763533G>A	ENST00000251076.5	-	29	7563	c.7276C>T	c.(7276-7278)Cct>Tct	p.P2426S	RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000449909.3_Missense_Mutation_p.P1790S|DMXL2_ENST00000543779.2_Missense_Mutation_p.P2427S	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2426						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		GGCCTTCCAGGGACGAGCATT	0.413000													44	61					0	0	1	0	0
KDELR3	11015	broad.mit.edu	37	22	38878539	38878539	+	Nonstop_Mutation	SNP	T	T	C			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr22:38878539T>C	ENST00000216014.4	+	5	815	c.643T>C	c.(643-645)Tga>Cga	p.*215R	KDELR3_ENST00000471268.1_3'UTR	NM_006855.2	NP_006846.1	O43731	ERD23_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3	0					protein retention in ER lumen|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	ER retention sequence binding|receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)	13	Melanoma(58;0.0286)					AATGCCAATCTGAGGACCTTC	0.363000													9	15					0	0	1	0	0
ARHGEF3	50650	broad.mit.edu	37	3	56763490	56763490	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:56763490G>A	ENST00000413728.2	-	10	1950	c.1407C>T	c.(1405-1407)tcC>tcT	p.S469S	ARHGEF3_ENST00000338458.4_Silent_p.S495S|ARHGEF3_ENST00000496106.1_Silent_p.S469S|ARHGEF3_ENST00000296315.3_Silent_p.S463S|ARHGEF3_ENST00000497267.1_Silent_p.S434S	NM_001128616.1	NP_001122088.1	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor (GEF) 3	463					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	25				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		ACGATCCCTCGGAGTCAAGCA	0.498000													34	38					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116632264	116632264	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:116632264G>A	ENST00000395715.3	-	3	638	c.61C>T	c.(61-63)Cct>Tct	p.P21S	TRPS1_ENST00000220888.5_Missense_Mutation_p.P8S|TRPS1_ENST00000519674.1_Missense_Mutation_p.P8S|TRPS1_ENST00000519076.1_Missense_Mutation_p.P8S|TRPS1_ENST00000520276.1_Missense_Mutation_p.P12S	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	8					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTTCTCAGAGGGGGGTTCTTT	0.418000									Langer-Giedion syndrome				13	51					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95164286	95164286	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:95164286G>A	ENST00000027335.3	-	13	1730	c.1606C>T	c.(1606-1608)Cct>Tct	p.P536S	CDH17_ENST00000450165.2_Missense_Mutation_p.P536S|CDH17_ENST00000441892.2_Missense_Mutation_p.P322S	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	536	Cadherin 5.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			AGAGGCTCAGGATTTTCTGCT	0.403000													14	61					0	0	1	0	0
MYL2	4633	broad.mit.edu	37	12	111348978	111348978	+	Splice_Site	SNP	A	A	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:111348978A>G	ENST00000228841.8	-	7	451	c.402_splice	c.e7-1	p.V135_splice	MYL2_ENST00000548438.1_Splice_Site_p.V121_splice	NM_000432.3	NP_000423.2	P10916	MLRV_HUMAN	myosin, light chain 2, regulatory, cardiac, slow	135	EF-hand 3.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	12						CATCTGGTCAACCTGCAATGA	0.612000													40	51					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143585	55143585	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:55143585C>T	ENST00000396331.1	+	6	915	c.558C>T	c.(556-558)ccC>ccT	p.P186P	LILRB1_ENST00000396321.2_Silent_p.P186P|LILRB1_ENST00000396332.4_Silent_p.P186P|LILRB1_ENST00000396315.1_Silent_p.P186P|LILRB1_ENST00000396317.1_Silent_p.P186P|LILRB1_ENST00000448689.1_Silent_p.P186P|LILRB1_ENST00000434867.2_Silent_p.P186P|LILRB1_ENST00000427581.2_Silent_p.P222P|LILRB1_ENST00000324602.7_Silent_p.P186P|LILRB1_ENST00000396327.3_Silent_p.P186P|LILRB1_ENST00000418536.2_Silent_p.P186P	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	186	Ig-like C2-type 2.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity	p.P186P(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CCGTGGGCCCCGTGAGCCCGA	0.592000										HNSCC(37;0.09)			43	53					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690140	33690140	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:33690140C>T	ENST00000394566.1	-	4	959	c.687G>A	c.(685-687)agG>agA	p.R229R	SLFN11_ENST00000308377.4_Silent_p.R229R	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	229						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGGAATTGTCCTTTTTACAT	0.393000													22	48					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153694839	153694839	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:153694839G>A	ENST00000369682.3	+	16	3095	c.2920G>A	c.(2920-2922)Gag>Aag	p.E974K		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	974	IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GAGGGACAGCGAGTGCCAGTT	0.697000													39	46					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103068572	103068572	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:103068572G>A	ENST00000264260.2	+	12	2320	c.1731G>A	c.(1729-1731)agG>agA	p.R577R	IL18RAP_ENST00000409369.1_Silent_p.R435R	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	577					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						TTACCTCTAGGATTTTTCAGT	0.512000													49	55					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518778	113518778	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:113518778C>T	ENST00000284601.3	-	4	2437	c.2369G>A	c.(2368-2370)cGa>cAa	p.R790Q		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	790					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TACTGTATCTCGTTGACAAAG	0.398000													21	23					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158263018	158263018	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:158263018G>A	ENST00000368170.3	+	5	1185	c.906G>A	c.(904-906)atG>atA	p.M302I		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	302					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					ACTTTTCCATGAATTGGATTG	0.378000													58	71					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48696375	48696375	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:48696375G>A	ENST00000544264.1	-	1	3973	c.3693C>T	c.(3691-3693)agC>agT	p.S1231S	CELSR3_ENST00000164024.4_Silent_p.S1231S			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	1231	Cadherin 9.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTAGCTTTCGGCTGAGTCGCA	0.587000													13	14					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84203728	84203728	+	Missense_Mutation	SNP	G	G	A	rs144990549		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr16:84203728G>A	ENST00000378553.5	+	8	1418	c.1294G>A	c.(1294-1296)Gag>Aag	p.E432K	DNAAF1_ENST00000563818.1_3'UTR|DNAAF1_ENST00000334315.5_Intron	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	432	Pro-rich.		E -> D (in dbSNP:rs9972733).		axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						GGTTAAAGGAGAGGACGGAGA	0.617000													26	32					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7168080	7168080	+	Silent	SNP	A	A	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:7168080A>G	ENST00000341500.5	-	7	1548	c.1509T>C	c.(1507-1509)tcT>tcC	p.S503S	INSR_ENST00000302850.5_Silent_p.S503S	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	503					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCCGAATGTAAGAAAATTTAA	0.448000													19	12					0	0	1	0	0
LEMD3	23592	broad.mit.edu	37	12	65639998	65639998	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:65639998C>T	ENST00000308330.2	+	13	2655	c.2629C>T	c.(2629-2631)Cag>Tag	p.Q877*		NM_001167614.1|NM_014319.4	NP_001161086.1|NP_055134.2	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	877	Interaction with SMAD1, SMAD2, SMAD3 and SMAD5.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	36			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		TCGCTTTCCCCAGGCTCTCAC	0.373000													54	29					0	0	1	0	0
SPR	6697	broad.mit.edu	37	2	73118628	73118628	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:73118628T>C	ENST00000234454.5	+	3	821	c.748T>C	c.(748-750)Ttc>Ctc	p.F250L	SPR_ENST00000498749.1_3'UTR	NM_003124.4	NP_003115.1	P35270	SPRE_HUMAN	sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)	250					nitric oxide biosynthetic process|tetrahydrobiopterin biosynthetic process	cytoplasm	aldo-keto reductase (NADP) activity|NADP binding|sepiapterin reductase activity			lung(4)|ovary(2)	6						AAAGGACGAGTTCAAGTCTGG	0.512000													17	21					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	166011151	166011151	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:166011151C>T	ENST00000360093.3	-	11	1682	c.1191G>A	c.(1189-1191)ggG>ggA	p.G397G	SCN3A_ENST00000409101.3_Silent_p.G397G|SCN3A_ENST00000283254.7_Silent_p.G397G	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	397						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TGTATGTTTTCCCAGCAGCAC	0.398000													15	17					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23191094	23191094	+	Silent	SNP	G	G	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:23191094G>T	ENST00000389131.3	-	5	1155	c.786C>A	c.(784-786)tcC>tcA	p.S262S		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	262	SRCR 2.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TGCAGTCCATGGAGAATGGCC	0.607000													15	31					1.49906e-05	1.49906e-05	1	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144917888	144917888	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:144917888G>A	ENST00000529945.1	-	7	2326	c.1887C>T	c.(1885-1887)acC>acT	p.T629T	PDE4DIP_ENST00000369356.4_Silent_p.T466T|PDE4DIP_ENST00000369354.3_Silent_p.T466T|PDE4DIP_ENST00000313382.9_Silent_p.T532T|PDE4DIP_ENST00000530740.1_Silent_p.T603T|PDE4DIP_ENST00000369359.4_Silent_p.T603T|PDE4DIP_ENST00000369349.3_Silent_p.T466T|PDE4DIP_ENST00000369351.3_Silent_p.T466T|PDE4DIP_ENST00000313431.9_Silent_p.T629T|PDE4DIP_ENST00000479408.2_Silent_p.T253T			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	466					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTGCTTCAAGGGTTTTGTCTG	0.368000			T	PDGFRB	MPD								34	169					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47682606	47682606	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr6:47682606G>A	ENST00000283303.2	+	6	1883	c.1625G>A	c.(1624-1626)gGc>gAc	p.G542D	GPR115_ENST00000371220.1_Missense_Mutation_p.G599D|GPR115_ENST00000327753.3_Missense_Mutation_p.G542D	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	542					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CCAGAGAAAGGCTACATGAGA	0.478000													48	61					0	0	1	0	0
PLS1	5357	broad.mit.edu	37	3	142389898	142389898	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:142389898G>A	ENST00000337777.3	+	4	511	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	PLS1_ENST00000457734.2_Missense_Mutation_p.E100K|PLS1_ENST00000497002.1_Missense_Mutation_p.E100K	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	100						cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						TAACAAGAGGGAAGGGATTAC	0.343000													36	50					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75829185	75829185	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr6:75829185G>A	ENST00000322507.8	-	45	7400	c.7091C>T	c.(7090-7092)tCa>tTa	p.S2364L	COL12A1_ENST00000416123.2_Missense_Mutation_p.S2364L|COL12A1_ENST00000345356.6_Missense_Mutation_p.S1200L|COL12A1_ENST00000483888.2_Missense_Mutation_p.S2364L	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2364	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TTGCACAAATGAAACCTGAAG	0.443000													29	6					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	79971575	79971575	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:79971575G>A	ENST00000466387.1	+	7	889	c.165G>A	c.(163-165)aaG>aaA	p.K55K	CTNNA2_ENST00000541047.1_Silent_p.K55K|CTNNA2_ENST00000496558.1_Silent_p.K55K|CTNNA2_ENST00000540488.1_Silent_p.K55K|CTNNA2_ENST00000361291.4_Silent_p.K89K|CTNNA2_ENST00000402739.4_Silent_p.K55K			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	55					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						GGAGGTCAAAGAAAGCCCATG	0.413000													15	13					0	0	1	0	0
DET1	55070	broad.mit.edu	37	15	89056264	89056264	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:89056264G>A	ENST00000564406.1	-	6	1764	c.1604C>T	c.(1603-1605)cCt>cTt	p.P535L	DET1_ENST00000268148.8_Missense_Mutation_p.P524L|DET1_ENST00000444300.1_Missense_Mutation_p.P535L	NM_017996.3	NP_060466.2	Q7L5Y6	DET1_HUMAN	de-etiolated homolog 1 (Arabidopsis)	524						nucleus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			AGGCTCAAAAGGGTGAAAGGT	0.557000													15	18					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55357630	55357630	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:55357630C>T	ENST00000524622.1	-	6	798	c.137G>A	c.(136-138)cGa>cAa	p.R46Q	TESPA1_ENST00000531122.1_Missense_Mutation_p.R46Q|TESPA1_ENST00000532804.1_Missense_Mutation_p.R46Q|TESPA1_ENST00000316577.8_Missense_Mutation_p.R184Q|TESPA1_ENST00000449076.1_Missense_Mutation_p.R184Q|TESPA1_ENST00000524959.1_5'UTR	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	184								p.R46Q(1)|p.R184Q(1)									GGTGAAAAATCGGGCGGGTAT	0.517000													31	39					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551383	248551383	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:248551383C>T	ENST00000355728.2	+	1	474	c.474C>T	c.(472-474)ctC>ctT	p.L158L		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGTTTTCTCCTCACCCCCA	0.567000													12	23					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10916378	10916378	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr21:10916378G>A	ENST00000298232.7	-	19	1581	c.1214C>T	c.(1213-1215)tCg>tTg	p.S405L	TPTE_ENST00000361285.4_Missense_Mutation_p.S423L|TPTE_ENST00000415664.2_Intron|TPTE_ENST00000342420.5_Missense_Mutation_p.S385L	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	423					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.S405L(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACGAGGAATCGAATAAATAAT	0.388000													11	60					0	0	1	0	0
CSNK1G2	1455	broad.mit.edu	37	19	1980168	1980168	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:1980168G>A	ENST00000255641.8	+	12	1709	c.1214G>A	c.(1213-1215)aGg>aAg	p.R405K		NM_001319.6	NP_001310.3	P78368	KC1G2_HUMAN	casein kinase 1, gamma 2	405					sphingolipid metabolic process|Wnt receptor signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(1)|lung(3)|prostate(1)|skin(1)|stomach(1)	8		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCTTCAAGAGGAGAAAGAGA	0.652000													25	29					0	0	1	0	0
GGT3P	2679	broad.mit.edu	37	22	18769203	18769203	+	RNA	SNP	G	G	A	rs111245818		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr22:18769203G>A	ENST00000412448.1	-	0	1083																											AGCCAGCCGCGGCAGGGTCAG	0.637000													6	37					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				16	25					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7267789	7267789	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:7267789G>A	ENST00000341500.5	-	2	258	c.219C>T	c.(217-219)ttC>ttT	p.F73F	INSR_ENST00000302850.5_Silent_p.F73F	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	73					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGAGGTCTCGGAAATCTTCGG	0.502000													17	15					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7654044	7654044	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:7654044C>T	ENST00000359156.4	-	3	350	c.148G>A	c.(148-150)Gag>Aag	p.E50K	CD163_ENST00000396620.3_Missense_Mutation_p.E50K|CD163_ENST00000432237.2_Missense_Mutation_p.E50K|CD163_ENST00000541972.1_Missense_Mutation_p.E38K	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	50					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						AGCCTCAGCTCCTTGTCTGTT	0.438000													40	37					0	0	1	0	0
TBX19	9095	broad.mit.edu	37	1	168274382	168274382	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:168274382C>T	ENST00000367821.3	+	6	915	c.864C>T	c.(862-864)caC>caT	p.H288H		NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	288					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					TCCGAGGACACCGGCAGGCTC	0.587000													39	41					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181714493	181714493	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:181714493G>A	ENST00000357570.5	+	26	3894	c.3582G>A	c.(3580-3582)atG>atA	p.M1194I	CACNA1E_ENST00000367570.1_Intron|CACNA1E_ENST00000367567.4_Intron|CACNA1E_ENST00000367573.2_Intron|CACNA1E_ENST00000358338.5_Missense_Mutation_p.M1175I|CACNA1E_ENST00000360108.3_Intron|CACNA1E_ENST00000526775.1_Intron			Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1243					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ttaacagcatgaaattgggag	0.428000													14	20					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15905351	15905351	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:15905351C>T	ENST00000308940.8	+	1	591	c.493C>T	c.(493-495)Cac>Tac	p.H165Y		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						GGCCATTTTCCACCTCGCCTT	0.597000													20	36					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039296	11039296	+	RNA	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr21:11039296G>A	ENST00000470054.1	-	0	907									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGTGTGTAACGACTTCAATGT	0.388000													19	234					0	0	1	0	0
FAM86HP	729375	broad.mit.edu	37	3	129821749	129821749	+	RNA	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:129821749C>T	ENST00000500074.2	-	0	396																											CTGGGCAATACAGCACGTCTA	0.597000													16	25					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100155377	100155377	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:100155377C>T	ENST00000263174.4	+	7	1936	c.1561C>T	c.(1561-1563)Cca>Tca	p.P521S	PALMD_ENST00000605497.1_Missense_Mutation_p.P521S	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	521					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		CCACCATTCCCCATTTGATGC	0.448000													22	26					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3030250	3030250	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:3030250G>A	ENST00000381127.1	+	11	1647	c.1426G>A	c.(1426-1428)Gta>Ata	p.V476I	ARSF_ENST00000537104.1_Missense_Mutation_p.V476I|ARSF_ENST00000359361.2_Missense_Mutation_p.V476I	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	476						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGTGACCCCGGTATTCCAGCC	0.512000													40	43					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2444150	2444150	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr11:2444150C>T	ENST00000452833.1	-	1	125	c.117_splice	c.e1+1	p.K39_splice	TRPM5_ENST00000155858.6_Splice_Site_p.K39_splice|TRPM5_ENST00000533060.1_Splice_Site_p.K39_splice|TRPM5_ENST00000528453.1_Splice_Site_p.K39_splice			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	39						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CTGCCCTTACCTTGCCTCGCT	0.657000													9	28					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23191095	23191095	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:23191095G>A	ENST00000389131.3	-	5	1154	c.785C>T	c.(784-786)tCc>tTc	p.S262F		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	262	SRCR 2.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		GCAGTCCATGGAGAATGGCCA	0.602000													14	28					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22380960	22380960	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr11:22380960G>A	ENST00000263160.3	+	4	897	c.458_splice	c.e4-1	p.V154_splice		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	154					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						CTATTTCAGGGTTTTCGGAGC	0.343000													16	11					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3228497	3228497	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:3228497C>T	ENST00000217939.6	-	7	7901	c.7747G>A	c.(7747-7749)Gat>Aat	p.D2583N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2583	Ig-like C2-type 10.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTCTGCAGATCGGTGCCATTG	0.647000													7	4					0	0	1	0	0
TEX101	83639	broad.mit.edu	37	19	43920262	43920262	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:43920262C>T	ENST00000602198.1	+	5	572	c.130C>T	c.(130-132)Ctg>Ttg	p.L44L	TEX101_ENST00000253435.7_Silent_p.L44L|TEX101_ENST00000601707.1_3'UTR|TEX101_ENST00000598265.1_Silent_p.L26L	NM_031451.4	NP_113639.4	Q9BY14	TX101_HUMAN	testis expressed 101	26						anchored to membrane|plasma membrane				large_intestine(1)|lung(12)|ovary(1)|skin(1)	15		Prostate(69;0.0199)				GGGCCTAGAGCTGTATTGTCA	0.502000													14	18					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103368612	103368612	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:103368612C>T	ENST00000428762.1	-	7	858	c.699G>A	c.(697-699)gcG>gcA	p.A233A	RELN_ENST00000343529.5_Silent_p.A233A|RELN_ENST00000424685.2_Silent_p.A233A	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	233					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.A233A(2)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CATGCATAATCGCGCCACACT	0.443000													21	15					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106843842	106843842	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:106843842G>A	ENST00000276185.4	+	16	2672	c.2672G>A	c.(2671-2673)aGg>aAg	p.R891K				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	891						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GGCGCTCGGAGGAAGCTGCCC	0.612000													16	11					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112588	248112588	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:248112588G>A	ENST00000357191.3	+	1	429	c.429G>A	c.(427-429)atG>atA	p.M143I	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GTGTGCTGATGATAACAGGGT	0.433000													41	60					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36708162	36708162	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr22:36708162G>A	ENST00000216181.5	-	14	1890	c.1660C>T	c.(1660-1662)Ccc>Tcc	p.P554S		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	554	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity	p.P554T(1)		NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						TGGAACTTGGGGTGGGTGCCC	0.612000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				33	53					0	0	1	0	0
VPS51	738	broad.mit.edu	37	11	64878928	64878928	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr11:64878928T>C	ENST00000279281.3	+	10	2310	c.2218T>C	c.(2218-2220)Tgg>Cgg	p.W740R	VPS51_ENST00000527646.1_3'UTR|AP003068.9_ENST00000528887.1_RNA	NM_013265.2	NP_037397.2			vacuolar protein sorting 51 homolog (S. cerevisiae)																		GCTCTACCTGTGGCGTTTTGT	0.637000													23	31					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65792842	65792842	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr11:65792842C>T	ENST00000312106.5	-	1	1146	c.1009G>A	c.(1009-1011)Gat>Aat	p.D337N		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	337					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CCGGGGGCATCGTGAATCAGG	0.592000													14	25					0	0	1	0	0
OR4L1	122742	broad.mit.edu	37	14	20528335	20528335	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr14:20528335C>T	ENST00000315683.1	+	1	132	c.132C>T	c.(130-132)ctC>ctT	p.L44L		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GAAACATTCTCATTATGGTCA	0.398000													56	48					0	0	1	0	0
MTNR1A	4543	broad.mit.edu	37	4	187454897	187454897	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr4:187454897C>T	ENST00000307161.5	-	2	1200	c.999G>A	c.(997-999)tgG>tgA	p.W333*	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	333					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	GAGACGGTTTCCATTTAACCC	0.478000													25	45					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46256364	46256364	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr20:46256364C>T	ENST00000372004.3	+	7	808	c.592C>T	c.(592-594)Cgt>Tgt	p.R198C	NCOA3_ENST00000371997.3_Missense_Mutation_p.R198C|NCOA3_ENST00000371998.3_Missense_Mutation_p.R198C|NCOA3_ENST00000341724.6_Missense_Mutation_p.R198C|NCOA3_ENST00000497292.1_3'UTR	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	198					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						ATTTAATTGCCGTATGTTGAT	0.378000													27	34					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18025416	18025416	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:18025416C>T	ENST00000205890.5	+	2	3640	c.3302C>T	c.(3301-3303)cCc>cTc	p.P1101L		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1101	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					GAGCCCCTGCCCAAGGGGGGT	0.677000													34	61					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57476832	57476832	+	Missense_Mutation	SNP	C	C	T	rs142236626		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:57476832C>T	ENST00000371236.2	-	13	1821	c.1558G>A	c.(1558-1560)Gaa>Aaa	p.E520K	DAB1_ENST00000414851.2_Missense_Mutation_p.E502K|DAB1_ENST00000371234.4_Missense_Mutation_p.E520K|DAB1_ENST00000371231.1_Missense_Mutation_p.E553K|DAB1_ENST00000439789.2_Missense_Mutation_p.E434K|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000420954.2_Missense_Mutation_p.E518K			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	553					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						TCTTGCTCTTCGCTTTTGCTG	0.423000													25	37					0	0	1	0	0
LIPC	3990	broad.mit.edu	37	15	58855785	58855785	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:58855785G>C	ENST00000414170.3	+	9	1538	c.1251G>C	c.(1249-1251)aaG>aaC	p.K417N	LIPC_ENST00000433326.2_Missense_Mutation_p.K356N|LIPC_ENST00000356113.6_Missense_Mutation_p.K417N|LIPC_ENST00000299022.5_Missense_Mutation_p.K417N			P11150	LIPC_HUMAN	lipase, hepatic	417	PLAT.				cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity	p.K417N(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TCATGATCAAGTTCAAGTGGG	0.493000													7	49					0	0	1	0	0
EVL	51466	broad.mit.edu	37	14	100604171	100604171	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr14:100604171C>T	ENST00000544450.2	+	11	1421	c.1138C>T	c.(1138-1140)Cca>Tca	p.P380S	EVL_ENST00000392920.3_Intron|EVL_ENST00000402714.2_Intron			Q9UI08	EVL_HUMAN	Enah/Vasp-like	184	EVH2 block C.|EVH2.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			cervix(1)|large_intestine(5)|lung(3)|ovary(3)|urinary_tract(2)	14		Melanoma(154;0.152)				CACATGTCCCCCAGGGTTTGG	0.592000													25	21					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147051353	147051353	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr5:147051353C>T	ENST00000265272.5	-	2	484	c.17G>A	c.(16-18)cGa>cAa	p.R6Q	JAKMIP2_ENST00000507386.1_Missense_Mutation_p.R6Q|JAKMIP2_ENST00000333010.6_Intron	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	6						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCTTATTTCGCCCTTTCTT	0.458000													19	3					0	0	1	0	0
OR1J2	26740	broad.mit.edu	37	9	125273723	125273723	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr9:125273723C>T	ENST00000335302.5	+	1	643	c.643C>T	c.(643-645)Ctg>Ttg	p.L215L		NM_054107.1	NP_473448.1	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J, member 2	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(7)|stomach(1)	26						CATGTGTATCCTGGTATCATA	0.517000													18	4					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31383009	31383009	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr16:31383009C>T	ENST00000268296.4	+	17	2185	c.2064C>T	c.(2062-2064)ccC>ccT	p.P688P	ITGAX_ENST00000562522.1_Silent_p.P688P	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	688					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GCCTGAGTCCCCGTGCCACCT	0.617000													27	35					0	0	1	0	0
SLC27A2	11001	broad.mit.edu	37	15	50489714	50489714	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:50489714G>A	ENST00000267842.5	+	2	728	c.496G>A	c.(496-498)Gaa>Aaa	p.E166K	SLC27A2_ENST00000380902.4_Missense_Mutation_p.E166K|SLC27A2_ENST00000544960.1_5'UTR	NM_003645.3	NP_003636.2	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid transporter), member 2	166					bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		AGCAGCTGTCGAAGAGATACT	0.333000													11	12					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765104	77765104	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:77765104C>T	ENST00000521891.2	+	10	6395	c.5947C>T	c.(5947-5949)Cgt>Tgt	p.R1983C	ZFHX4_ENST00000455469.2_Missense_Mutation_p.R1938C|ZFHX4_ENST00000050961.6_Missense_Mutation_p.R1938C|ZFHX4_ENST00000518282.1_Missense_Mutation_p.R1957C	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1938	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAAATTTGCTCGTCAATACAG	0.458000										HNSCC(33;0.089)			11	27					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123181208	123181208	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:123181208G>A	ENST00000371160.1	+	9	962	c.672G>A	c.(670-672)atG>atA	p.M224I	STAG2_ENST00000218089.9_Missense_Mutation_p.M224I|STAG2_ENST00000354548.5_Missense_Mutation_p.M155I|STAG2_ENST00000371144.3_Missense_Mutation_p.M224I|STAG2_ENST00000371145.3_Missense_Mutation_p.M224I|STAG2_ENST00000371157.3_Missense_Mutation_p.M224I|STAG2_ENST00000469481.1_Intron			Q8N3U4	STAG2_HUMAN	stromal antigen 2	224					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						AAATAGCTATGAAGTTGATGA	0.289000													13	23					0	0	1	0	0
C10orf82	143379	broad.mit.edu	37	10	118424324	118424324	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr10:118424324A>T	ENST00000369210.3	-	4	463	c.409T>A	c.(409-411)Ttc>Atc	p.F137I	C10orf82_ENST00000588184.1_Missense_Mutation_p.F137I	NM_144661.2	NP_653262.1	Q8WW14	CJ082_HUMAN	chromosome 10 open reading frame 82	137										endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7				all cancers(201;0.0143)		ATCTCCAGGAAGTCCTTGTAG	0.552000													42	5					0	0	1	0	0
NFIX	4784	broad.mit.edu	37	19	13192528	13192528	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:13192528C>T	ENST00000358552.3	+	6	987	c.987C>T	c.(985-987)ttC>ttT	p.F329F	NFIX_ENST00000592199.1_Silent_p.F371F|NFIX_ENST00000360105.4_Silent_p.F333F|NFIX_ENST00000588228.1_Silent_p.F324F|NFIX_ENST00000397661.2_Silent_p.F371F|NFIX_ENST00000587760.1_Silent_p.F363F|NFIX_ENST00000587260.1_Silent_p.F370F|NFIX_ENST00000585575.1_Silent_p.F363F			Q14938	NFIX_HUMAN	nuclear factor I/X (CCAAT-binding transcription factor)	371					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			CCCTGCACTTCCCCTCCACGT	0.642000													20	25					0	0	1	0	0
OAS2	4939	broad.mit.edu	37	12	113435446	113435446	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:113435446C>T	ENST00000392583.2	+	4	956	c.749C>T	c.(748-750)aCc>aTc	p.T250I	OAS2_ENST00000342315.4_Missense_Mutation_p.T250I|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	250	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						GGCGTCAGAACCGTACTGGAG	0.502000													14	12					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67713708	67713708	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:67713708A>T	ENST00000335894.4	+	16	2364	c.2298A>T	c.(2296-2298)aaA>aaT	p.K766N	IQCH-AS1_ENST00000559298.1_lincRNA|IQCH_ENST00000546225.1_Missense_Mutation_p.K423N|IQCH_ENST00000360277.4_Missense_Mutation_p.K427N|IQCH_ENST00000358767.3_Missense_Mutation_p.K502N	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	766										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		CCAACGGGAAAATCAGCGTGC	0.547000													15	19					0	0	1	0	0
DENND1C	79958	broad.mit.edu	37	19	6467911	6467911	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:6467911G>A	ENST00000381480.2	-	23	2122	c.2010C>T	c.(2008-2010)ccC>ccT	p.P670P	DENND1C_ENST00000543576.1_Silent_p.P626P	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	670						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						GAGAGGGTTTGGGGTCCCCCC	0.567000													6	5					0	0	1	0	0
SCNN1B	6338	broad.mit.edu	37	16	23379183	23379183	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr16:23379183C>T	ENST00000343070.2	+	5	959	c.783C>T	c.(781-783)ttC>ttT	p.F261F	SCNN1B_ENST00000568923.1_Silent_p.F234F|SCNN1B_ENST00000307331.5_Silent_p.F306F|SCNN1B_ENST00000568085.1_Silent_p.F261F	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	261					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	TTAGGAACTTCACGTCCATCT	0.532000													24	51					0	0	1	0	0
PRSS37	136242	broad.mit.edu	37	7	141536292	141536292	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:141536292C>T	ENST00000350549.3	-	5	982	c.611G>A	c.(610-612)gGa>gAa	p.G204E	PRSS37_ENST00000438520.1_Missense_Mutation_p.G204E	NM_001008270.2|NM_001171951.1	NP_001008271.2|NP_001165422.1	A4D1T9	PRS37_HUMAN	protease, serine, 37	204	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(3)	15						CACCTCGATTCCCTGGAGCTT	0.498000													30	32					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105416167	105416167	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr14:105416167G>A	ENST00000333244.5	-	7	5740	c.5621C>T	c.(5620-5622)cCg>cTg	p.P1874L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1874						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGAAGGGAGCGGAATGCAGAG	0.662000													105	131					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569971	241569971	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:241569971G>A	ENST00000319838.5	+	6	1544	c.602G>A	c.(601-603)aGg>aAg	p.R201K	GPR35_ENST00000430267.1_Missense_Mutation_p.R201K|GPR35_ENST00000438013.2_Missense_Mutation_p.R232K|GPR35_ENST00000407714.1_Missense_Mutation_p.R201K|GPR35_ENST00000403859.1_Missense_Mutation_p.R201K	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	201						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		CTGGCCCAGAGGCCACCCACC	0.657000													24	43					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60030380	60030380	+	Silent	SNP	A	A	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:60030380A>G	ENST00000397786.2	-	27	6139	c.6063T>C	c.(6061-6063)ggT>ggC	p.G2021G		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2021					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GTACAGGAGAACCAGTTGGAG	0.463000													26	39					0	0	1	0	0
OSBPL3	26031	broad.mit.edu	37	7	24874318	24874318	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:24874318C>T	ENST00000313367.2	-	15	1984	c.1533G>A	c.(1531-1533)cgG>cgA	p.R511R	OSBPL3_ENST00000431825.2_Silent_p.R444R|OSBPL3_ENST00000396429.1_Silent_p.R475R|OSBPL3_ENST00000409069.1_Silent_p.R444R|OSBPL3_ENST00000352860.1_Silent_p.R480R|OSBPL3_ENST00000396431.1_Silent_p.R480R|OSBPL3_ENST00000353930.1_Silent_p.R475R	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	511					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						ACGTTCTTCTCCGGGACTTCG	0.512000													20	36					0	0	1	0	0
SNAI3	333929	broad.mit.edu	37	16	88747884	88747884	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr16:88747884G>A	ENST00000332281.5	-	2	401	c.315C>T	c.(313-315)ctC>ctT	p.L105L	SNAI3-AS1_ENST00000563261.1_RNA	NM_178310.3	NP_840101.1	Q3KNW1	SNAI3_HUMAN	snail family zinc finger 3	105					oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|kidney(1)|lung(1)|ovary(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(80;0.048)		GGCTGTCTTTGAGGGGTACAA	0.677000													50	74					0	0	1	0	0
EVL	51466	broad.mit.edu	37	14	100604172	100604172	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr14:100604172C>T	ENST00000544450.2	+	11	1422	c.1139C>T	c.(1138-1140)cCa>cTa	p.P380L	EVL_ENST00000392920.3_Intron|EVL_ENST00000402714.2_Intron			Q9UI08	EVL_HUMAN	Enah/Vasp-like	184	EVH2 block C.|EVH2.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			cervix(1)|large_intestine(5)|lung(3)|ovary(3)|urinary_tract(2)	14		Melanoma(154;0.152)				ACATGTCCCCCAGGGTTTGGG	0.587000													24	19					0	0	1	0	0
NUDCD3	23386	broad.mit.edu	37	7	44432080	44432080	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:44432080T>C	ENST00000355451.6	-	5	1070	c.791A>G	c.(790-792)aAc>aGc	p.N264S	NUDCD3_ENST00000460110.1_5'UTR	NM_015332.3	NP_056147.2	Q8IVD9	NUDC3_HUMAN	NudC domain containing 3	264	CS.									endometrium(2)|large_intestine(1)|lung(3)|skin(1)	7						CTTGCTCAGGTTCACCTGGGG	0.597000													3	59					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152060576	152060576	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:152060576A>G	ENST00000368806.1	-	2	108	c.44T>C	c.(43-45)tTc>tCc	p.F15S		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	15							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			ATATTTGTGGAATGTCTCAAT	0.463000													33	54					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42168801	42168801	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr20:42168801C>T	ENST00000444063.1	+	17	2046	c.1914C>T	c.(1912-1914)ccC>ccT	p.P638P	L3MBTL1_ENST00000418998.1_Silent_p.P706P|L3MBTL1_ENST00000373135.3_Silent_p.P638P|L3MBTL1_ENST00000427442.2_Silent_p.P706P|L3MBTL1_ENST00000373134.1_Silent_p.P643P			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	638					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						CCCTCACGCCCGATGTCGTGC	0.617000													16	24					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51743354	51743354	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:51743354C>T	ENST00000395052.3	+	2	589	c.355C>T	c.(355-357)Cac>Tac	p.H119Y	GRM2_ENST00000475478.1_Intron|GRM2_ENST00000442933.2_Missense_Mutation_p.H119Y	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	119					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TGGCTCACGCCACATCTGCCC	0.582000													31	32					0	0	1	0	0
PTHLH	5744	broad.mit.edu	37	12	28116412	28116412	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:28116412C>T	ENST00000535992.1	-	3	739	c.393G>A	c.(391-393)ggG>ggA	p.G131G	PTHLH_ENST00000545234.1_Silent_p.G131G|RP11-993B23.3_ENST00000538113.1_RNA|PTHLH_ENST00000395868.3_Silent_p.G131G|PTHLH_ENST00000354417.3_Silent_p.G131G|PTHLH_ENST00000539239.1_Silent_p.G131G|PTHLH_ENST00000395872.1_Silent_p.G131G|PTHLH_ENST00000538310.1_Silent_p.G131G|PTHLH_ENST00000201015.4_Silent_p.G131G			P12272	PTHR_HUMAN	parathyroid hormone-like hormone	131					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	10	Lung SC(9;0.184)					CCTTGCGTTTCCCGGGCTTGC	0.522000													35	50					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690141	33690141	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:33690141C>T	ENST00000394566.1	-	4	958	c.686G>A	c.(685-687)aGg>aAg	p.R229K	SLFN11_ENST00000308377.4_Missense_Mutation_p.R229K	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	229						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGGAATTGTCCTTTTTACATA	0.388000													22	48					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803493	142803493	+	RNA	SNP	T	T	C	rs80149641	by1000genomes	TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:142803493T>C	ENST00000423385.1	-	0	1472																											TGTACATTTATTATTGATTTA	0.323000													9	47					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50099719	50099719	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:50099719C>T	ENST00000418929.2	+	4	2139	c.2127C>T	c.(2125-2127)agC>agT	p.S709S		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	432	Pro-rich.						DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CCAGTGCCAGCCTGGATGAGG	0.682000													9	13					0	0	1	0	0
SDHAP1	255812	broad.mit.edu	37	3	195701333	195701333	+	RNA	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:195701333G>A	ENST00000427841.1	-	0	1491					NR_003264.2																						CCAATAGCGAGTTTGCCCCGA	0.592000													6	43					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195515520	195515520	+	Silent	SNP	A	A	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:195515520A>T	ENST00000463781.3	-	2	3390	c.2931T>A	c.(2929-2931)ctT>ctA	p.L977L	MUC4_ENST00000475231.1_Silent_p.L977L|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	982	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGTGACAGGAAGAGGGGTGG	0.577000													8	12					0	0	1	0	0
MICB	4277	broad.mit.edu	37	6	31473468	31473468	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr6:31473468G>A	ENST00000252229.6	+	2	224	c.145G>A	c.(145-147)Gga>Aga	p.G49R	MICB_ENST00000399150.3_Missense_Mutation_p.G49R|MICB_ENST00000538442.1_Missense_Mutation_p.G17R	NM_005931.3	NP_005922.2	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	49					antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						TCTCGCTGAGGGACATCTGGA	0.562000													25	36					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24187611	24187611	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:24187611G>A	ENST00000265769.4	+	11	1196	c.1086G>A	c.(1084-1086)gtG>gtA	p.V362V	ADAM28_ENST00000518516.1_3'UTR|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000437154.2_Silent_p.V362V|RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000397649.3_Silent_p.V109V|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000540823.1_Silent_p.V129V	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	362	Peptidase M12B.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CAATATGTGTGATGGACAAAG	0.468000													29	24					0	0	1	0	0
UIMC1	51720	broad.mit.edu	37	5	176334117	176334117	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr5:176334117G>A	ENST00000377219.2	-	13	2079	c.1913C>T	c.(1912-1914)tCa>tTa	p.S638L	UIMC1_ENST00000511320.1_Missense_Mutation_p.S637L|UIMC1_ENST00000506128.1_Missense_Mutation_p.S471L|UIMC1_ENST00000377227.4_Missense_Mutation_p.S637L	NM_016290.4	NP_057374.3	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	637				D -> N (in Ref. 4; BAG51153).	double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	21	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTCCTCACCTGAAGTCTTGTG	0.483000													8	0					0	0	1	0	0
MAN2B1	4125	broad.mit.edu	37	19	12774538	12774538	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:12774538G>A	ENST00000456935.2	-	5	782	c.742C>T	c.(742-744)Ccg>Tcg	p.P248S	MAN2B1_ENST00000221363.4_Missense_Mutation_p.P248S	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	248					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TCCGCGGTCGGGGGCTTCAGG	0.607000													11	9					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142724121	142724121	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:142724121G>C	ENST00000350513.2	-	1	161	c.99C>G	c.(97-99)ttC>ttG	p.F33L		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					TCACTAAATAGAAGAAAAAGA	0.433000													19	35					0	0	1	0	0
DET1	55070	broad.mit.edu	37	15	89056265	89056265	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:89056265G>A	ENST00000564406.1	-	6	1763	c.1603C>T	c.(1603-1605)Cct>Tct	p.P535S	DET1_ENST00000268148.8_Missense_Mutation_p.P524S|DET1_ENST00000444300.1_Missense_Mutation_p.P535S	NM_017996.3	NP_060466.2	Q7L5Y6	DET1_HUMAN	de-etiolated homolog 1 (Arabidopsis)	524						nucleus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			GGCTCAAAAGGGTGAAAGGTG	0.552000													15	18					0	0	1	0	0
CBS	875	broad.mit.edu	37	21	44478320	44478320	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr21:44478320G>A	ENST00000398165.3	-	15	1661	c.1402C>T	c.(1402-1404)Ctg>Ttg	p.L468L	CBS_ENST00000398168.1_Silent_p.L468L|CBS_ENST00000398158.1_Silent_p.L468L|CBS_ENST00000544202.1_Silent_p.L380L|CBS_ENST00000352178.5_Silent_p.L468L|CBS_ENST00000359624.3_Silent_p.L468L	NM_000071.2	NP_000062.1	P35520	CBS_HUMAN	cystathionine-beta-synthase	468	CBS.				cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(8)	17					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	CCGGCAAGCAGGGACGAGAGC	0.587000													12	18					0	0	1	0	0
KRCC1	51315	broad.mit.edu	37	2	88327862	88327862	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:88327862G>A	ENST00000347055.3	-	4	614	c.221C>T	c.(220-222)tCa>tTa	p.S74L		NM_016618.1	NP_057702.1	Q9NPI7	KRCC1_HUMAN	lysine-rich coiled-coil 1	74										cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)	7						AATATTGCATGATCTTGGGTA	0.468000													16	17					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35749373	35749373	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr20:35749373C>T	ENST00000400441.3	-	16	2042	c.2043G>A	c.(2041-2043)atG>atA	p.M681I	MROH8_ENST00000217333.8_Missense_Mutation_p.M510I|MROH8_ENST00000441008.2_Missense_Mutation_p.M667I					maestro heat-like repeat family member 8																		TATTCTTTTCCATGATGTTGA	0.453000													10	8					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74621474	74621474	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:74621474C>T	ENST00000156626.7	-	9	1940	c.1741G>A	c.(1741-1743)Gat>Aat	p.D581N		NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	581					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						ATCCCTTCATCGTGTAGCCGC	0.532000													15	28					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51135998	51135998	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:51135998G>A	ENST00000338916.4	-	2	852	c.219C>T	c.(217-219)ttC>ttT	p.F73F	SYT3_ENST00000600079.1_Silent_p.F73F|SYT3_ENST00000544769.1_Silent_p.F73F|SYT3_ENST00000593901.1_Silent_p.F73F	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	73						cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		TCCAGGACACGAAGAGAGAGA	0.627000													27	55					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48314172	48314172	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:48314172G>A	ENST00000435803.1	+	17	4933	c.4909G>A	c.(4909-4911)Gat>Aat	p.D1637N		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1637					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						ACTGATAAGGGATGTGTTCAA	0.388000													23	48					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110768751	110768751	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:110768751C>T	ENST00000369787.3	+	3	1797	c.1770C>T	c.(1768-1770)ttC>ttT	p.F590F	KCNC4_ENST00000412512.2_Intron|KCNC4_ENST00000413138.3_Silent_p.F590F|KCNC4_ENST00000438661.2_Silent_p.F590F	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	590					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTGCCTGCTTCCTGCTCAGCA	0.657000													21	32					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10783893	10783893	+	Missense_Mutation	SNP	G	G	A	rs140174760	byFrequency	TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:10783893G>A	ENST00000075503.3	-	5	722	c.202C>T	c.(202-204)Cct>Tct	p.P68S		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	68						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						CTAGGTGGAGGAACAGGGGCA	0.527000										HNSCC(73;0.22)			22	32					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179600704	179600704	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:179600704C>T	ENST00000589042.1	-	50	14693	c.14469G>A	c.(14467-14469)gtG>gtA	p.V4823V	TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.V4506V|TTN_ENST00000342992.6_Silent_p.V3579V|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4506	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTTTCTATCACAGGAGTCC	0.468000													20	33					0	0	1	0	0
MLLT10	8028	broad.mit.edu	37	10	22016848	22016848	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr10:22016848T>A	ENST00000377072.3	+	17	2450	c.2102T>A	c.(2101-2103)cTc>cAc	p.L701H	MLLT10_ENST00000446906.2_Missense_Mutation_p.L685H|MLLT10_ENST00000307729.7_Missense_Mutation_p.L685H|MLLT10_ENST00000377059.3_Missense_Mutation_p.L685H	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	701					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						CGAGGAAGTCTCTCGCCACGG	0.423000			T	"""MLL, PICALM, CDK6"""	AL								6	7					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52415658	52415658	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:52415658G>A	ENST00000420323.2	+	49	7872	c.7611G>A	c.(7609-7611)atG>atA	p.M2537I		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2537					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTGCACAGATGATGCAGGTGA	0.562000													8	9					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3002528	3002528	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:3002528C>T	ENST00000381127.1	+	6	872	c.651C>T	c.(649-651)ctC>ctT	p.L217L	ARSF_ENST00000537104.1_Silent_p.L217L|ARSF_ENST00000359361.2_Silent_p.L217L	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	217						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTCCCTGGCTCCTGATCTTCT	0.547000													28	50					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298641	107298641	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr9:107298641G>A	ENST00000374781.2	-	1	496	c.454C>T	c.(454-456)Cgt>Tgt	p.R152C		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						GCCACATAACGATCAAATGCC	0.473000													3	61					0	0	1	0	0
CHST4	10164	broad.mit.edu	37	16	71570893	71570893	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr16:71570893G>A	ENST00000338482.5	+	3	656	c.313G>A	c.(313-315)Gac>Aac	p.D105N	ZNF19_ENST00000568446.1_Intron|CHST4_ENST00000572450.1_Missense_Mutation_p.D105N|RP11-510M2.9_ENST00000572693.1_RNA|CHST4_ENST00000539698.3_Missense_Mutation_p.D105N			Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	105					cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	21						CTTCTTGTGCGACATGAGCGT	0.607000													25	34					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389181	20389181	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr14:20389181G>A	ENST00000315915.4	+	1	441	c.416G>A	c.(415-417)aGg>aAg	p.R139K		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATGAGCCGAAGGACATGCACT	0.453000													50	132					0	0	1	0	0
DEPTOR	64798	broad.mit.edu	37	8	121019091	121019091	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr8:121019091C>T	ENST00000286234.5	+	7	1103	c.973C>T	c.(973-975)Ccg>Tcg	p.P325S	DEPTOR_ENST00000518057.1_3'UTR|DEPTOR_ENST00000523492.1_Missense_Mutation_p.P224S	NM_022783.2	NP_073620.2	Q8TB45	DPTOR_HUMAN	DEP domain containing MTOR-interacting protein	325					intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	18						TCCCGGGGCTCCGTATGCAAG	0.507000													41	16					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49457119	49457119	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr10:49457119T>A	ENST00000374201.3	-	3	556	c.254A>T	c.(253-255)aAg>aTg	p.K85M	FRMPD2_ENST00000305531.3_Missense_Mutation_p.K83M|FRMPD2_ENST00000407470.4_Missense_Mutation_p.K76M	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	85	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		TTCAGGGGCCTTGAAAGGAGC	0.547000													14	3					0	0	1	0	0
LRCH2	57631	broad.mit.edu	37	X	114418999	114418999	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:114418999C>T	ENST00000317135.8	-	3	626	c.596G>A	c.(595-597)gGg>gAg	p.G199E	LRCH2_ENST00000538422.1_Missense_Mutation_p.G199E	NM_020871.3	NP_065922.3	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 2	199										breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	19						TTTTAACTTCCCAATTTCTTC	0.289000													8	18					0	0	1	0	0
CREBZF	58487	broad.mit.edu	37	11	85375769	85375769	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr11:85375769G>A	ENST00000527447.1	-	1	377	c.151C>T	c.(151-153)Ccc>Tcc	p.P51S	CREBZF_ENST00000531515.1_Intron|CREBZF_ENST00000534224.1_Intron	NM_001039618.2	NP_001034707.1	Q9NS37	ZHANG_HUMAN	CREB/ATF bZIP transcription factor	51					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				TTGCGGCCGGGAGATCCGGCC	0.726000													18	33					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2786272	2786272	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:2786272C>T	ENST00000399655.1	+	40	5106	c.4841C>T	c.(4840-4842)aCc>aTc	p.T1614I	CACNA1C_ENST00000399638.1_Missense_Mutation_p.T1642I|CACNA1C_ENST00000399603.1_Missense_Mutation_p.T1614I|CACNA1C_ENST00000347598.4_Missense_Mutation_p.T1662I|CACNA1C_ENST00000399591.1_Missense_Mutation_p.T1622I|CACNA1C_ENST00000327702.7_Missense_Mutation_p.T1614I|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000399644.1_Missense_Mutation_p.T1614I|CACNA1C_ENST00000399621.1_Missense_Mutation_p.T1633I|CACNA1C_ENST00000406454.3_Missense_Mutation_p.T1614I|CACNA1C_ENST00000399629.1_Missense_Mutation_p.T1631I|CACNA1C_ENST00000399601.1_Missense_Mutation_p.T1614I|CACNA1C_ENST00000399597.1_Missense_Mutation_p.T1614I|CACNA1C_ENST00000399634.1_Missense_Mutation_p.T1614I|CACNA1C_ENST00000399606.1_Missense_Mutation_p.T1634I|CACNA1C_ENST00000399637.1_Missense_Mutation_p.T1633I|CACNA1C_ENST00000399595.1_Missense_Mutation_p.T1622I|CACNA1C_ENST00000402845.3_Missense_Mutation_p.T1633I|CACNA1C_ENST00000399649.1_Missense_Mutation_p.T1620I|CACNA1C_ENST00000335762.5_Missense_Mutation_p.T1639I|CACNA1C_ENST00000399641.1_Missense_Mutation_p.T1614I|CACNA1C_ENST00000344100.3_Missense_Mutation_p.T1655I|CACNA1C_ENST00000399617.1_Missense_Mutation_p.T1614I	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1662					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GATGAGGTCACCGTTGGCAAG	0.512000													10	8					0	0	1	0	0
DUOXA1	90527	broad.mit.edu	37	15	45412968	45412968	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:45412968A>G	ENST00000558996.1	-	4	295	c.241T>C	c.(241-243)Tac>Cac	p.Y81H	DUOXA1_ENST00000560572.1_Missense_Mutation_p.Y126H|DUOXA1_ENST00000558422.1_Missense_Mutation_p.Y81H|DUOXA1_ENST00000267803.4_Missense_Mutation_p.Y126H|DUOXA1_ENST00000430224.2_Missense_Mutation_p.Y81H|DUOXA1_ENST00000559014.1_Missense_Mutation_p.Y126H	NM_001276267.1|NM_001276268.1	NP_001263196.1|NP_001263197.1	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	126					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		TCCTCGTTGTAATTGATGGTC	0.582000													60	75					0	0	1	0	0
WIPF2	147179	broad.mit.edu	37	17	38416832	38416832	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:38416832C>T	ENST00000323571.4	+	3	349	c.109C>T	c.(109-111)Cga>Tga	p.R37*	WIPF2_ENST00000536600.1_Nonsense_Mutation_p.R37*|WIPF2_ENST00000583130.1_Nonsense_Mutation_p.R37*|WIPF2_ENST00000394103.3_Nonsense_Mutation_p.R37*|WIPF2_ENST00000585043.1_Nonsense_Mutation_p.R37*|WIPF2_ENST00000494757.1_3'UTR	NM_133264.4	NP_573571.1	Q8TF74	WIPF2_HUMAN	WAS/WASL interacting protein family, member 2	37	WH2.					cytoplasm|cytoskeleton	actin binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	30						GCAGCGGGGTCGAGGCGCCCT	0.522000										HNSCC(43;0.11)			15	28					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882449	228882449	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:228882449C>T	ENST00000392056.3	-	7	3167	c.3121G>A	c.(3121-3123)Gaa>Aaa	p.E1041K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.E1041K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1041						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCTGCCACTTCATTGGCAAAA	0.512000													30	36					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21552450	21552450	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr3:21552450C>T	ENST00000281523.2	-	4	860	c.342G>A	c.(340-342)atG>atA	p.M114I	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	114						nucleus	nucleic acid binding|zinc ion binding	p.M114I(1)		NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						GCTTATTTTTCATGGCTTCCA	0.463000													18	25					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12661487	12661487	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:12661487C>T	ENST00000425538.1	+	12	2488	c.2288C>T	c.(2287-2289)tCa>tTa	p.S763L	MYOCD_ENST00000343344.4_Missense_Mutation_p.S715L|MYOCD_ENST00000395988.1_Missense_Mutation_p.S667L	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	715					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCAGCAATTTCAGAGGTAACA	0.408000													17	19					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95931110	95931110	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr10:95931110C>T	ENST00000260766.3	+	4	2300	c.1666C>T	c.(1666-1668)Ctt>Ttt	p.L556F	PLCE1_ENST00000371375.1_Missense_Mutation_p.L248F|PLCE1_ENST00000371385.3_Missense_Mutation_p.L248F|PLCE1_ENST00000371380.2_Missense_Mutation_p.L556F	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	556	Ras-GEF.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				AGTCGACTACCTTTGCTTCTT	0.537000													41	5					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55098691	55098691	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:55098691G>A	ENST00000251377.3	+	9	1463	c.1330G>A	c.(1330-1332)Gat>Aat	p.D444N	LILRA2_ENST00000391737.1_Missense_Mutation_p.D415N|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391738.3_Missense_Mutation_p.D444N|LILRA2_ENST00000251376.3_Missense_Mutation_p.D427N|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		ACACCCCCAGGATTACACAGT	0.587000													20	41					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47569796	47569796	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:47569796G>A	ENST00000253048.5	-	15	3766	c.3729C>T	c.(3727-3729)ccC>ccT	p.P1243P	ZC3H4_ENST00000594019.1_5'UTR	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1243							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CCCCGGGCTGGGGTGGGGCAC	0.701000													8	7					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179621344	179621344	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:179621344G>A	ENST00000589042.1	-	46	11083	c.10859C>T	c.(10858-10860)tCc>tTc	p.S3620F	TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000360870.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S3449F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3307							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTGTGGATGGAACTTTGAGA	0.378000													15	32					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120911459	120911459	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:120911459G>A	ENST00000310396.5	+	22	3310	c.2843G>A	c.(2842-2844)gGg>gAg	p.G948E		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		TTTCTACAGGGGAAGTGTGGA	0.323000													23	47					0	0	1	0	0
CD99L2	83692	broad.mit.edu	37	X	149983391	149983391	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:149983391G>A	ENST00000370377.3	-	4	338	c.221C>T	c.(220-222)gCt>gTt	p.A74V	CD99L2_ENST00000437787.2_Missense_Mutation_p.A74V|CD99L2_ENST00000355149.3_Intron|CD99L2_ENST00000466436.1_Intron|CD99L2_ENST00000346693.4_5'UTR	NM_001242614.1|NM_031462.3	NP_001229543.1|NP_113650.2	Q8TCZ2	C99L2_HUMAN	CD99 molecule-like 2	74					cell adhesion	cell junction|integral to membrane				endometrium(4)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CAAAGCATCAGCCAAGTCCAA	0.438000													46	47					0	0	1	0	0
PIGU	128869	broad.mit.edu	37	20	33173345	33173345	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr20:33173345G>A	ENST00000374820.2	-	8	782	c.762C>T	c.(760-762)ttC>ttT	p.F254F	PIGU_ENST00000452740.2_Silent_p.F274F|PIGU_ENST00000480175.1_Intron			Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class U	274					attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	9						AGAAGTACCAGAAAAGACCAA	0.388000													27	49					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23200768	23200768	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr16:23200768C>T	ENST00000300061.2	+	3	537	c.394C>T	c.(394-396)Cca>Tca	p.P132S		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	132					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	GTATGGCTTTCCAGAGTCCCG	0.577000													81	71					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26423117	26423117	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr22:26423117G>A	ENST00000335473.7	+	43	7427	c.7177G>A	c.(7177-7179)Gat>Aat	p.D2393N	MYO18B_ENST00000407587.2_Missense_Mutation_p.D2394N|MYO18B_ENST00000536101.1_Missense_Mutation_p.D2393N	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2393						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CTCTGTGGACGATGCGGGCTG	0.597000													47	36					0	0	1	0	0
DDX53	168400	broad.mit.edu	37	X	23018769	23018769	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:23018769G>A	ENST00000327968.5	+	1	683	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	199						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						CTGGAGAAAGGAAAATTTCAA	0.388000													25	50					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857692	9857692	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr16:9857692C>T	ENST00000396573.2	-	14	4018	c.3709G>A	c.(3709-3711)Gat>Aat	p.D1237N	GRIN2A_ENST00000535259.1_Missense_Mutation_p.D1080N|GRIN2A_ENST00000562109.1_Missense_Mutation_p.D1237N|GRIN2A_ENST00000330684.3_Missense_Mutation_p.D1237N|GRIN2A_ENST00000404927.2_Missense_Mutation_p.D1237N|GRIN2A_ENST00000396575.2_Missense_Mutation_p.D1237N	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1237					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.D1237N(1)		NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGCAGGCATCGCACTTGAAG	0.582000													46	61					0	0	1	0	0
KLK8	11202	broad.mit.edu	37	19	51501088	51501088	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:51501088C>T	ENST00000600767.1	-	6	1035	c.546G>A	c.(544-546)aaG>aaA	p.K182K	CTB-147C22.9_ENST00000594512.1_RNA|KLK8_ENST00000320838.5_Intron|KLK8_ENST00000593490.1_Intron|KLK8_ENST00000291726.7_Silent_p.K182K|KLK8_ENST00000598195.1_5'UTR|KLK8_ENST00000347619.4_Silent_p.K41K|KLK8_ENST00000391806.2_Silent_p.K227K			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	182	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		CCTCACACTTCTTCTGGGGAA	0.517000													25	34					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915104	119915104	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:119915104C>T	ENST00000331113.4	+	1	1383	c.418C>T	c.(418-420)Cgc>Tgc	p.R140C		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	140					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GTACAAGGATCGCAGGCGAGA	0.602000													74	71					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196964938	196964938	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:196964938G>A	ENST00000367414.5	+	5	827	c.771G>A	c.(769-771)gtG>gtA	p.V257V	CFHR5_ENST00000256785.4_Silent_p.V233V	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	233	Sushi 4.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						ATGAAGTAGTGGAATATGATT	0.363000													15	9					0	0	1	0	0
COMMD4	54939	broad.mit.edu	37	15	75632325	75632325	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:75632325C>T	ENST00000267935.8	+	8	778	c.579C>T	c.(577-579)acC>acT	p.T193T	COMMD4_ENST00000567195.1_Silent_p.T107T|COMMD4_ENST00000562789.1_Silent_p.T140T|COMMD4_ENST00000564815.1_Silent_p.T171T|COMMD4_ENST00000338995.6_Silent_p.T134T	NM_017828.3	NP_060298.2	Q9H0A8	COMD4_HUMAN	COMM domain containing 4	193	COMM.					cytoplasm	protein binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|prostate(1)	10						AGGCCCAGACCCTGATGAGCT	0.637000													5	24					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71495434	71495434	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr5:71495434C>T	ENST00000296755.7	+	5	6550	c.6252C>T	c.(6250-6252)ctC>ctT	p.L2084L		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2084						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ATTTATGCCTCGTGTCCTCTT	0.493000													61	10					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90816651	90816651	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr4:90816651C>T	ENST00000394980.1	+	2	848	c.529C>T	c.(529-531)Cga>Tga	p.R177*	MMRN1_ENST00000264790.2_Nonsense_Mutation_p.R177*|MMRN1_ENST00000394981.1_Nonsense_Mutation_p.R143*			Q13201	MMRN1_HUMAN	multimerin 1	177					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		cGTGGGAAATCGAGCCCCACG	0.493000													16	24					0	0	1	0	0
LIPC	3990	broad.mit.edu	37	15	58855790	58855790	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:58855790A>G	ENST00000414170.3	+	9	1543	c.1256A>G	c.(1255-1257)aAg>aGg	p.K419R	LIPC_ENST00000433326.2_Missense_Mutation_p.K358R|LIPC_ENST00000356113.6_Missense_Mutation_p.K419R|LIPC_ENST00000299022.5_Missense_Mutation_p.K419R			P11150	LIPC_HUMAN	lipase, hepatic	419	PLAT.				cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		ATCAAGTTCAAGTGGGAAAAC	0.502000													7	50					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31040061	31040061	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:31040061G>A	ENST00000355537.3	+	4	3682	c.3535G>A	c.(3535-3537)Gat>Aat	p.D1179N		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.D1179N(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGAGAACAACGATGAAGAGGA	0.557000													16	25					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231817	21231817	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:21231817G>A	ENST00000233242.1	-	26	8050	c.7923C>T	c.(7921-7923)atC>atT	p.I2641I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2641					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACCTGGATGGGATTTTTATAT	0.353000													45	46					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52130829	52130829	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:52130829G>A	ENST00000222107.4	-	6	1306	c.1168C>T	c.(1168-1170)Ccc>Tcc	p.P390S	SIGLEC5_ENST00000599649.1_Missense_Mutation_p.P390S|SIGLEC5_ENST00000570106.2_Missense_Mutation_p.P390S|SIGLEC5_ENST00000534261.2_Missense_Mutation_p.P390S|SIGLEC5_ENST00000429354.3_Missense_Mutation_p.P390S			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	390					cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TTGGCCCAGGGCCCAGCTGAG	0.657000													29	25					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21501017	21501017	+	Splice_Site	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr18:21501017C>T	ENST00000313654.9	+	61	8283	c.8043_splice	c.e61+1	p.S2681_splice	LAMA3_ENST00000399516.3_Splice_Site_p.S2625_splice|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Splice_Site_p.S1016_splice|LAMA3_ENST00000269217.6_Splice_Site_p.S1072_splice	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2681	Laminin G-like 2.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.S2681L(1)		NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAGACCATTCGGTACACCTT	0.383000													6	10					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185963957	185963957	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:185963957G>A	ENST00000271588.4	+	24	3745	c.3516G>A	c.(3514-3516)aaG>aaA	p.K1172K	HMCN1_ENST00000367492.2_Silent_p.K1172K	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1172	Ig-like C2-type 9.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TTCCTCCAAAGATACAGCGTG	0.403000													22	16					0	0	1	0	0
OR2T4	127074	broad.mit.edu	37	1	248525018	248525018	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:248525018C>T	ENST00000366475.1	+	1	136	c.136C>T	c.(136-138)Ctg>Ttg	p.L46L		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGATTTCATCCTGTTGGGACT	0.468000													45	37					0	0	1	0	0
KRTAP5-9	3846	broad.mit.edu	37	11	71259984	71259984	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr11:71259984C>T	ENST00000528743.2	+	1	519	c.281C>T	c.(280-282)tCa>tTa	p.S94L		NM_005553.3	NP_005544.4	P26371	KRA59_HUMAN	keratin associated protein 5-9	94	8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament				kidney(1)|large_intestine(1)|lung(6)|prostate(3)	11						GGCTGTGGGTCATCCTGCTGC	0.627000													94	93					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115343993	115343993	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr10:115343993C>T	ENST00000351270.3	+	11	1420	c.1324C>T	c.(1324-1326)Ccc>Tcc	p.P442S	HABP2_ENST00000542051.1_Missense_Mutation_p.P416S	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	442	Peptidase S1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		TGGGTCCTTTCCCTCTGGGAG	0.512000													20	3					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81372774	81372774	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:81372774C>T	ENST00000222390.5	-	7	986	c.760G>A	c.(760-762)Ggc>Agc	p.G254S	HGF_ENST00000457544.2_Missense_Mutation_p.G249S|HGF_ENST00000453411.1_Missense_Mutation_p.G249S|HGF_ENST00000444829.2_Missense_Mutation_p.G254S	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	254	Kringle 2.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TCATCAAAGCCCTTGTCGGGA	0.493000													15	22					0	0	1	0	0
ZNF98	148198	broad.mit.edu	37	19	22574496	22574496	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:22574496C>T	ENST00000357774.5	-	4	1662	c.1541G>A	c.(1540-1542)gGa>gAa	p.G514E		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				GGGTTTCTCTCCAGTATGAAT	0.388000													12	26					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21245826	21245826	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:21245826C>T	ENST00000233242.1	-	18	2820	c.2693G>A	c.(2692-2694)gGg>gAg	p.G898E		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	898					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CATCTGGACCCCACTCCTAGC	0.498000													19	20					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95728961	95728961	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr5:95728961C>T	ENST00000311106.3	-	14	2243	c.2006G>A	c.(2005-2007)cGa>cAa	p.R669Q	CTD-2337A12.1_ENST00000502645.2_RNA|PCSK1_ENST00000513085.1_5'UTR|PCSK1_ENST00000508626.1_Missense_Mutation_p.R622Q	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	669					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity	p.R669Q(1)		NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGCAGGAGTCGCAGCATGGC	0.542000													38	2					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19753482	19753482	+	Splice_Site	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr13:19753482G>A	ENST00000400113.3	-	2	329	c.226_splice	c.e2+1	p.V75_splice		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	75			V -> L (in dbSNP:rs36215077).		'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		AGCACCTACCGACCACAGTGG	0.587000													18	18					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86089610	86089610	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr14:86089610G>A	ENST00000330753.4	+	2	2519	c.1752G>A	c.(1750-1752)cgG>cgA	p.R584R	FLRT2_ENST00000554746.1_Silent_p.R584R	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	584					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GGGGCCGGCGGAAAGATGATT	0.493000													41	64					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18564360	18564360	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr18:18564360A>G	ENST00000399799.1	-	20	3381	c.2441T>C	c.(2440-2442)tTa>tCa	p.L814S		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	814	Glu-rich.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					TGCTTCCAATAAAGTATTTAT	0.303000													13	14					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8862495	8862495	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr20:8862495G>A	ENST00000338037.6	+	32	3677	c.3650G>A	c.(3649-3651)tGa>tAa	p.*1217*	PLCB1_ENST00000378641.3_3'UTR	NM_015192.2	NP_056007.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	0					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity	p.*1217S(2)		NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						ACTCCTCTGTGAATGCTCCTG	0.522000													30	34					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233134884	233134884	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:233134884C>T	ENST00000258229.8	-	31	5804	c.5570G>A	c.(5569-5571)aGa>aAa	p.R1857K	PCNXL2_ENST00000344698.2_Missense_Mutation_p.R509K	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1857						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GGTCCTAATTCTGTCCAAAGT	0.537000													6	12					0	0	1	0	0
ACO2	50	broad.mit.edu	37	22	41923423	41923423	+	Splice_Site	SNP	C	C	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr22:41923423C>A	ENST00000396512.3	+	16	2177	c.2161_splice	c.e16+1	p.H720_splice	POLR3H_ENST00000396504.2_3'UTR|ACO2_ENST00000216254.4_Splice_Site_p.H695_splice|POLR3H_ENST00000355209.4_3'UTR			Q99798	ACON_HUMAN	aconitase 2, mitochondrial	695					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(3)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	23						CCAGGATCCACGGTGAGCTGG	0.627000											OREG0026589	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	38					7.92952e-12	7.98914e-12	1	1	0
MKRN3	7681	broad.mit.edu	37	15	23810949	23810949	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:23810949C>T	ENST00000314520.3	+	1	496	c.20C>T	c.(19-21)cCc>cTc	p.P7L	MKRN3_ENST00000564592.1_Missense_Mutation_p.P7L|MKRN3_ENST00000568252.1_Missense_Mutation_p.P7L	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	7						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CCTGCAGCTCCCTCAGAAGCC	0.642000													6	12					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5461922	5461922	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:5461922C>T	ENST00000345221.3	-	4	2648	c.2094G>A	c.(2092-2094)agG>agA	p.R698R	NLRP1_ENST00000354411.3_Silent_p.R698R|NLRP1_ENST00000262467.5_Silent_p.R698R|NLRP1_ENST00000577119.1_Silent_p.R698R|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000269280.4_Silent_p.R698R|NLRP1_ENST00000572272.1_Silent_p.R698R	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	698					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GCATCAGGTTCCTCCCCTGAG	0.557000													34	45					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10215380	10215380	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:10215380C>T	ENST00000418404.3	-	31	4542	c.4379G>A	c.(4378-4380)tGg>tAg	p.W1460*	MYH13_ENST00000570743.1_Nonsense_Mutation_p.W1460*|MYH13_ENST00000252172.4_Nonsense_Mutation_p.W1460*			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1460					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CTTTTGCTTCCACTCTGCAAG	0.512000													12	16					0	0	1	0	0
ESX1	80712	broad.mit.edu	37	X	103495237	103495237	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:103495237G>A	ENST00000372588.4	-	4	976	c.893C>T	c.(892-894)cCg>cTg	p.P298L		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	298	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						CGCCATGGGCGGCCAGGGTGG	0.751000													22	24					0	0	1	0	0
STK36	27148	broad.mit.edu	37	2	219557366	219557366	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr2:219557366C>T	ENST00000295709.3	+	16	2255	c.1976C>T	c.(1975-1977)tCc>tTc	p.S659F	STK36_ENST00000392106.2_Missense_Mutation_p.S659F|STK36_ENST00000440309.1_Missense_Mutation_p.S659F|STK36_ENST00000392105.3_Missense_Mutation_p.S659F	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	659					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GGAGCCATTTCCTCTGCCCTG	0.572000													11	11					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47385827	47385827	+	Silent	SNP	G	G	A			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:47385827G>A	ENST00000398879.1	-	18	2775	c.2409C>T	c.(2407-2409)gcC>gcT	p.A803A	TNS3_ENST00000355730.3_Silent_p.A563A|TNS3_ENST00000311160.9_Silent_p.A803A			Q68CZ2	TENS3_HUMAN	tensin 3	803						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						GCAGGTTTGGGGCATAGTCCA	0.597000													26	31					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181684487	181684487	+	Silent	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:181684487C>T	ENST00000526775.1	+	9	1350	c.1185C>T	c.(1183-1185)ctC>ctT	p.L395L	CACNA1E_ENST00000367570.1_Silent_p.L395L|CACNA1E_ENST00000357570.5_Silent_p.L346L|CACNA1E_ENST00000367567.4_Silent_p.L2L|CACNA1E_ENST00000367573.2_Silent_p.L395L|CACNA1E_ENST00000358338.5_Silent_p.L346L|CACNA1E_ENST00000360108.3_Silent_p.L395L	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	395					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AAGTCATGCTCGCTGAAGAAA	0.398000													4	4					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457210	45457210	+	RNA	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr12:45457210C>T	ENST00000548424.1	+	0	448																											CAGGTGCATCCTTTCTTATAG	0.408000													6	5					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54308587	54308587	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:54308587C>T	ENST00000324134.6	-	5	2529	c.2361G>A	c.(2359-2361)atG>atA	p.M787I	NLRP12_ENST00000535162.1_Missense_Mutation_p.M787I|NLRP12_ENST00000391773.1_Missense_Mutation_p.M788I|NLRP12_ENST00000391775.3_Missense_Mutation_p.M787I|NLRP12_ENST00000345770.5_Missense_Mutation_p.M788I|NLRP12_ENST00000354278.3_Missense_Mutation_p.M787I|NLRP12_ENST00000351894.4_Missense_Mutation_p.M787I|NLRP12_ENST00000391772.1_Missense_Mutation_p.M788I	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	787					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AAAGCAGCATCATGCCTGGGA	0.547000													44	41					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240255569	240255571	+	In_Frame_Del	DEL	GGC	GGC	-	rs71929261		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr1:240255569_240255571delGGC	ENST00000319653.9	+	1	390_392	c.160_162delGGC	c.(160-162)del	p.G59del		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	59					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.G197delG(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGGGGGAgggggcggcggcggcg	0.665													3	6	---	---	---	---					
TNPO1	3842	broad.mit.edu	37	5	72157710	72157726	+	Frame_Shift_Del	DEL	TGTTGGATTCTGAAGAT	TGTTGGATTCTGAAGAT	-			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr5:72157710_72157726delTGTTGGATTCTGAAGAT	ENST00000337273.5	+	5	857_873	c.431_447delTGTTGGATTCTGAAGAT	c.(430-447)cfs	p.LLDSED144fs	TNPO1_ENST00000523768.1_Frame_Shift_Del_p.LLDSED94fs|TNPO1_ENST00000513944.1_3'UTR|TNPO1_ENST00000506351.2_Frame_Shift_Del_p.LLDSED136fs|TNPO1_ENST00000447967.2_Intron|TNPO1_ENST00000454282.1_Frame_Shift_Del_p.LLDSED94fs	NM_002270.3	NP_002261.3	Q92973	TNPO1_HUMAN	transportin 1	144					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		CTCTGTAGCCTGTTGGATTCTGAAGATTATAATACCT	0.359													8	4	---	---	---	---					
MSH3	4437	broad.mit.edu	37	5	79950742	79950750	+	In_Frame_Del	DEL	CCCCCAGCT	CCCCCAGCT	-	rs3045983		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr5:79950742_79950750delCCCCCAGCT	ENST00000265081.6	+	1	276_284	c.196_204delCCCCCAGCT	c.(196-204)del	p.PPA66del	DHFR_ENST00000439211.2_5'UTR	NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	66					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		gCCCCCAGCGCCCCCAGCTCCCGCCTTCC	0.732								Mismatch excision repair (MMR)					6	4	---	---	---	---					
MARCKS	4082	broad.mit.edu	37	6	114181210	114181210	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr6:114181210delA	ENST00000368635.4	+	2	835	c.454delA	c.(454-456)aafs	p.K156fs		NM_002356.5	NP_002347.5	P29966	MARCS_HUMAN	myristoylated alanine-rich protein kinase C substrate	156	Calmodulin-binding (PSD).				energy reserve metabolic process|regulation of insulin secretion	actin cytoskeleton|plasma membrane	actin filament binding|calmodulin binding	p.K155fs*12(1)		breast(1)|kidney(1)|large_intestine(1)|lung(1)	4		all_cancers(87;7.65e-05)|all_epithelial(87;0.000296)|all_hematologic(75;0.0172)|Colorectal(196;0.0317)|all_lung(197;0.198)		Epithelial(106;1.59e-07)|all cancers(137;9.85e-07)|OV - Ovarian serous cystadenocarcinoma(136;0.000322)		CGAGACCCCGAAAAAAAAAAA	0.612													4	5	---	---	---	---					
PMS2P4	5382	broad.mit.edu	37	7	66762433	66762433	+	RNA	DEL	A	A	-	rs68053451		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr7:66762433delA	ENST00000414507.1	-	0	184																											tctcaaaaagaaaaaaaaaaa	0.408													3	6	---	---	---	---					
CASC4	113201	broad.mit.edu	37	15	44624241	44624241	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr15:44624241delA	ENST00000299957.6	+	4	840	c.541delA	c.(541-543)aafs	p.K182fs	CASC4_ENST00000360824.3_Intron|CASC4_ENST00000345795.2_Frame_Shift_Del_p.K182fs	NM_138423.3	NP_612432.2	Q6P4E1	CASC4_HUMAN	cancer susceptibility candidate 4	182						integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(7)|ovary(1)|urinary_tract(2)	17		all_cancers(109;1.69e-13)|all_epithelial(112;3.94e-11)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.027)		all cancers(107;2.91e-20)|GBM - Glioblastoma multiforme(94;1.57e-06)|COAD - Colon adenocarcinoma(120;0.217)|Colorectal(105;0.237)		AGAAAATATTAAAAAGTTAGC	0.259													21	15	---	---	---	---					
MYO15A	51168	broad.mit.edu	37	17	18025395	18025396	+	Frame_Shift_Ins	INS	-	-	CAGGGCCC			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr17:18025395_18025396insCAGGGCCC	ENST00000205890.5	+	2	3619_3620	c.3281_3282insCAGGGCCC	c.(3280-3282)aagfs	p.K1094fs		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1094	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TTGGCGCCCATCAGGGCCCCAG	0.673													35	79	---	---	---	---					
HAUS8	93323	broad.mit.edu	37	19	17160706	17160707	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:17160706_17160707delGA	ENST00000593360.1	-	10	3044_3045	c.1026_1027delTC	c.(1024-1029)tcgtfs	p.SR342fs	HAUS8_ENST00000448593.2_Frame_Shift_Del_p.SR402fs|HAUS8_ENST00000253669.5_Frame_Shift_Del_p.SR403fs			Q9BT25	HAUS8_HUMAN	HAUS augmin-like complex, subunit 8	403					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)	12						CTCCCTGAACGAGAGAGAGAGG	0.495													7	166	---	---	---	---					
KMT2B	9757	broad.mit.edu	37	19	36224124	36224124	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr19:36224124delC	ENST00000420124.1	+	28	6674	c.6674delC	c.(6673-6675)tcfs	p.S2225fs	WBP7_ENST00000222270.7_Frame_Shift_Del_p.S2225fs|KMT2B_ENST00000607650.1_RNA																							CCCACCATTTCCCCCACGGCT	0.672													2	4	---	---	---	---					
MCM8	84515	broad.mit.edu	37	20	5935274	5935277	+	Frame_Shift_Del	DEL	TTGA	TTGA	-			TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chr20:5935274_5935277delTTGA	ENST00000378896.3	+	4	651_654	c.274_277delTTGA	c.(274-279)ttfs	p.LI92fs	MCM8_ENST00000378886.2_Frame_Shift_Del_p.LI92fs|MCM8_ENST00000378883.1_Frame_Shift_Del_p.LI92fs|MCM8_ENST00000265187.4_Frame_Shift_Del_p.LI92fs	NM_032485.4|NM_182802.1	NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	92					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						TAGCTCTCCTTTGATTGAGAAGAT	0.363													7	23	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50165596	50165597	+	RNA	DEL	AC	AC	-	rs72026364		TCGA-FS-A4FB-06A-11D-A25O-08	TCGA-FS-A4FB-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0E5B617A-AEB6-4E7F-B474-DEE19C4F4FD8	E6D7A41E-BB8E-4CB7-A7A6-F0519E0B3BBB	g.chrX:50165596_50165597delAC	ENST00000376025.2	-	0	816							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TAAAAGGTAAacacacacacac	0.411													5	5	---	---	---	---					
