Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LILRA4	23547	broad.mit.edu	37	19	54849692	54849692	+	Silent	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:54849692G>A	ENST00000291759.4	-	3	386	c.330C>T	c.(328-330)agC>agT	p.S110S		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	110	Ig-like C2-type 1.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CCAGGGGGTCGCTGGGCTCTG	0.607000													38	92					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31152920	31152920	+	Missense_Mutation	SNP	G	G	A	rs145749002	by1000genomes	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr16:31152920G>A	ENST00000268281.4	-	12	1829	c.1771C>T	c.(1771-1773)Cgg>Tgg	p.R591W	PRSS36_ENST00000569305.1_Missense_Mutation_p.R586W|PRSS36_ENST00000418068.2_Missense_Mutation_p.R591W	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	591	Peptidase S1 3.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						GCCTCCAGCCGCAGGCCACAG	0.682000													3	58					0	0	1	0	0
STAMBP	10617	broad.mit.edu	37	2	74058084	74058084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:74058084G>A	ENST00000394070.2	+	2	604	c.101G>A	c.(100-102)cGt>cAt	p.R34H	STAMBP_ENST00000394073.1_Missense_Mutation_p.R34H|STAMBP_ENST00000409707.1_Missense_Mutation_p.R34H|STAMBP_ENST00000536064.1_Missense_Mutation_p.R34H|STAMBP_ENST00000339566.3_Missense_Mutation_p.R34H	NM_213622.2	NP_998787.1	O95630	STABP_HUMAN	STAM binding protein	34	Interaction with CHMP3.				JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	18						ATTCCACCCCGTCGGTACTTC	0.517000													85	80					0	0	1	0	0
DDX4	54514	broad.mit.edu	37	5	55088554	55088554	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:55088554T>A	ENST00000505374.1	+	17	1480	c.1388T>A	c.(1387-1389)tTa>tAa	p.L463*	DDX4_ENST00000354991.5_Nonsense_Mutation_p.L429*|DDX4_ENST00000511853.1_Nonsense_Mutation_p.L314*|DDX4_ENST00000353507.5_Nonsense_Mutation_p.L429*|DDX4_ENST00000514278.2_Nonsense_Mutation_p.L443*	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	463	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				ATGAAGAAGTTAATTTCTTGC	0.363000													21	215					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86123866	86123866	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr15:86123866T>G	ENST00000394518.2	+	7	2662	c.2567T>G	c.(2566-2568)cTt>cGt	p.L856R	AKAP13_ENST00000361243.2_Missense_Mutation_p.L856R	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	856					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity	p.E855_G859>G(1)		NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GCTGCAGAGCTTCAGCACGGG	0.552000													49	125					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													4	52					0	0	1	0	0
NFATC4	4776	broad.mit.edu	37	14	24839702	24839702	+	Silent	SNP	A	A	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:24839702A>G	ENST00000413692.2	+	3	1431	c.1287A>G	c.(1285-1287)ggA>ggG	p.G429G	NFATC4_ENST00000556279.1_Silent_p.G398G|NFATC4_ENST00000422617.3_Silent_p.G354G|NFATC4_ENST00000554344.1_Silent_p.G296G|NFATC4_ENST00000250373.4_Silent_p.G366G|NFATC4_ENST00000554050.1_Silent_p.G366G|NFATC4_ENST00000554966.1_Silent_p.G379G|NFATC4_ENST00000553469.1_Silent_p.G398G|NFATC4_ENST00000554591.1_Silent_p.G429G|NFATC4_ENST00000539237.2_Silent_p.G398G|NFATC4_ENST00000555590.1_Silent_p.G379G|NFATC4_ENST00000556169.1_Silent_p.G354G|NFATC4_ENST00000553708.1_Silent_p.G366G|NFATC4_ENST00000440487.2_3'UTR|NFATC4_ENST00000554661.1_Silent_p.G296G|NFATC4_ENST00000555453.1_Silent_p.G354G|NFATC4_ENST00000557451.1_Silent_p.G296G|NFATC4_ENST00000553879.1_Silent_p.G296G|NFATC4_ENST00000424781.2_Silent_p.G379G	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	366	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		CTCCTCCAGGAGGTTCCCGGA	0.637000													26	49					0	0	1	0	0
LAMP5	24141	broad.mit.edu	37	20	9496748	9496748	+	Silent	SNP	C	C	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr20:9496748C>G	ENST00000246070.2	+	3	831	c.339C>G	c.(337-339)cgC>cgG	p.R113R	LAMP5_ENST00000427562.2_Intron	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	113						integral to membrane											GGGTGGATCGCGCATATGCAC	0.617000													13	46					0	0	1	0	0
BIRC2	329	broad.mit.edu	37	11	102221100	102221100	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr11:102221100C>A	ENST00000227758.2	+	2	1914	c.515C>A	c.(514-516)tCg>tAg	p.S172*	BIRC2_ENST00000530675.1_Nonsense_Mutation_p.S123*|BIRC2_ENST00000527910.1_3'UTR|BIRC2_ENST00000532672.1_Nonsense_Mutation_p.S151*	NM_001166.4|NM_001256163.1	NP_001157.1|NP_001243092.1	Q13490	BIRC2_HUMAN	baculoviral IAP repeat containing 2	172					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		ATCTCTTCATCGAGGACTAAC	0.418000													4	134					1	1	1	1	0
PTPRB	5787	broad.mit.edu	37	12	70953095	70953095	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr12:70953095G>T	ENST00000551525.1	-	18	4763	c.4739C>A	c.(4738-4740)tCt>tAt	p.S1580Y	PTPRB_ENST00000334414.6_Intron|PTPRB_ENST00000538708.1_Intron|PTPRB_ENST00000550358.1_Intron|PTPRB_ENST00000550857.1_Intron|PTPRB_ENST00000261266.5_Intron|PTPRB_ENST00000451516.2_Intron			P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTCCATTTGAGAAATAAGAGT	0.368000													49	134					3.50607e-19	3.81429e-19	1	1	0
GEM	2669	broad.mit.edu	37	8	95262715	95262715	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr8:95262715C>A	ENST00000297596.2	-	5	978	c.714G>T	c.(712-714)caG>caT	p.Q238H	GEM_ENST00000396194.2_Missense_Mutation_p.Q238H	NM_005261.3	NP_005252.1	P55040	GEM_HUMAN	GTP binding protein overexpressed in skeletal muscle	238					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			GAAGGCGCACCTGTCGCACAA	0.582000													67	71					1.30681e-28	1.47016e-28	1	1	0
TPK1	27010	broad.mit.edu	37	7	144288534	144288534	+	Silent	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr7:144288534C>T	ENST00000549981.1	-	9	855	c.132G>A	c.(130-132)ctG>ctA	p.L44L	TPK1_ENST00000378099.3_Intron|TPK1_ENST00000360057.3_Silent_p.L161L|TPK1_ENST00000547966.1_5'UTR|TPK1_ENST00000538212.2_Intron			Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1	161					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			large_intestine(3)|lung(12)|ovary(2)|urinary_tract(2)	19					Thiamine(DB00152)	GCAGGTAGATCAGCGATTCCT	0.423000													118	144					0	0	1	0	0
ARRDC2	27106	broad.mit.edu	37	19	18120412	18120412	+	Silent	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:18120412G>A	ENST00000222250.4	+	4	644	c.501G>A	c.(499-501)gcG>gcA	p.A167A	ARRDC2_ENST00000595712.1_3'UTR|ARRDC2_ENST00000379656.2_Silent_p.A162A	NM_015683.1	NP_056498.1	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2	167										endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)	12						CACCTCAAGCGGGGGCTCGGG	0.587000													47	164					0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63278567	63278567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr11:63278567G>A	ENST00000415491.2	+	5	1045	c.431G>A	c.(430-432)aGc>aAc	p.S144N	LGALS12_ENST00000425950.2_Intron|LGALS12_ENST00000394618.3_Missense_Mutation_p.S205N|LGALS12_ENST00000255684.5_Intron|LGALS12_ENST00000340246.5_Missense_Mutation_p.S206N	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	205	Galectin 1.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						CTGCTGATGAGCCCCAGGCTG	0.552000													7	79					0	0	1	0	0
SLC9A7	84679	broad.mit.edu	37	X	46466517	46466517	+	Missense_Mutation	SNP	G	G	A	rs146808441		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chrX:46466517G>A	ENST00000328306.4	-	17	2073	c.2048C>T	c.(2047-2049)aCg>aTg	p.T683M	SLC9A7_ENST00000464933.1_5'UTR	NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	683					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						CTCCAGACTCGTGGAGGCGGT	0.602000													38	2					0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90578514	90578514	+	RNA	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr6:90578514G>A	ENST00000551025.1	+	0	6942							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CTCACAAAAAGAGAAGAAACA	0.343000													7	10					0	0	1	0	0
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81443781	81443781	+	RNA	SNP	A	A	T	rs143569743	by1000genomes	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:81443781A>T	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							GACCACAAAGACGAGGAGGAG	0.622000													5	26					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274379	39274379	+	Silent	SNP	G	G	A	rs411996	by1000genomes	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:39274379G>A	ENST00000391413.2	-	1	227	c.189C>T	c.(187-189)acC>acT	p.T63T		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	63	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GGCGGCAGCAGGTGGGCTGGC	0.657000													4	96					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44178123	44178123	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr22:44178123G>T	ENST00000262726.7	-	3	329	c.76C>A	c.(76-78)Cat>Aat	p.H26N	EFCAB6_ENST00000356087.4_5'UTR|EFCAB6_ENST00000358439.4_5'UTR|EFCAB6_ENST00000396231.2_Intron	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	26					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GGTGAAGAATGGGGTCTTGAA	0.373000													11	198					2.23348e-06	2.40342e-06	1	1	0
CSNK1G1	53944	broad.mit.edu	37	15	64499781	64499781	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr15:64499781C>G	ENST00000303052.7	-	7	1115	c.692G>C	c.(691-693)aGa>aCa	p.R231T	CSNK1G1_ENST00000303032.6_Missense_Mutation_p.R231T|CTD-2116N17.1_ENST00000606793.1_Missense_Mutation_p.R213T|CSNK1G1_ENST00000607537.1_Missense_Mutation_p.R231T	NM_022048.3	NP_071331.2	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	231	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	13						CAAATCATCTCTCCGGCTTTG	0.453000													16	52					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85639647	85639647	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr4:85639647T>C	ENST00000322366.6	-	47	8038	c.7631A>G	c.(7630-7632)cAt>cGt	p.H2544R	WDFY3_ENST00000295888.4_Missense_Mutation_p.H2561R			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2561						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CACATAAAAATGCTCTTTACC	0.408000													72	54					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933112	43933112	+	Silent	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr20:43933112C>T	ENST00000537548.1	-	4	643	c.399G>A	c.(397-399)ccG>ccA	p.P133P	MATN4_ENST00000372751.4_Intron|MATN4_ENST00000372756.1_Silent_p.P133P|MATN4_ENST00000372754.1_Silent_p.P133P|MATN4_ENST00000353917.5_Silent_p.P133P|MATN4_ENST00000342716.4_Silent_p.P133P|MATN4_ENST00000360607.5_Silent_p.P133P|MATN4_ENST00000372753.1_Intron			O95460	MATN4_HUMAN	matrilin 4	133	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				GCTCCTCTGGCGGTCGCGCGC	0.716000													9	15					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142451278	142451278	+	RNA	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr8:142451278G>A	ENST00000430863.1	-	0	3123					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		TTCCTCTCACGCTCCTGTGGG	0.637000													34	28					0	0	1	0	0
DPY19L1	23333	broad.mit.edu	37	7	34997678	34997678	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr7:34997678G>A	ENST00000310974.4	-	11	1022	c.878C>T	c.(877-879)tCt>tTt	p.S293F	DPY19L1_ENST00000462134.2_Intron	NM_015283.1	NP_056098.1	Q2PZI1	D19L1_HUMAN	dpy-19-like 1 (C. elegans)	293						integral to membrane				endometrium(3)|kidney(5)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	31						AAGTGCAAGAGAAATCTGGAA	0.279000													20	16					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24537572	24537572	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:24537572A>T	ENST00000264463.4	-	3	950	c.443T>A	c.(442-444)aTc>aAc	p.I148N		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	148	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATGAATTTTGATCACAAACTC	0.418000										HNSCC(23;0.051)			61	174					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137650106	137650106	+	Silent	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:137650106C>T	ENST00000371817.3	+	18	2313	c.1899C>T	c.(1897-1899)gaC>gaT	p.D633D		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	633	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGGGTTTCGACGGCCTGGCTG	0.627000													67	10					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110839549	110839549	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr13:110839549G>T	ENST00000375820.4	-	25	1785	c.1664C>A	c.(1663-1665)aCa>aAa	p.T555K		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	555	Triple-helical region.		T -> P (in dbSNP:rs536174).		angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding	p.P555Q(1)		breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CGCTCTCCCTGTCATGCCGGG	0.572000													8	146					5.18039e-06	5.51461e-06	1	1	0
ACAP2	23527	broad.mit.edu	37	3	195102638	195102638	+	Silent	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr3:195102638G>A	ENST00000326793.6	-	3	455	c.225C>T	c.(223-225)gtC>gtT	p.V75V		NM_012287.5	NP_036419.3	Q15057	ACAP2_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	75	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	27						TAACCTCAACGACAGCATCAT	0.323000													7	63					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166892972	166892972	+	Silent	SNP	A	A	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:166892972A>G	ENST00000423058.2	-	16	3032	c.3015T>C	c.(3013-3015)gaT>gaC	p.D1005D	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Silent_p.D977D|SCN1A_ENST00000375405.3_Silent_p.D994D|SCN1A_ENST00000303395.4_Silent_p.D1005D|AC010127.3_ENST00000595268.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1005						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTTCATTATCATCATCAGTGG	0.343000													21	28					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178413398	178413398	+	Silent	SNP	C	C	G	rs140658210		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:178413398C>G	ENST00000231188.5	-	8	2035	c.1857G>C	c.(1855-1857)tcG>tcC	p.S619S	GRM6_ENST00000517717.1_Silent_p.S619S|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	619					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GCTCTCGGCCCGAGGCCCGGA	0.682000													8	55					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16021583	16021583	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr8:16021583A>T	ENST00000350896.3	-	5	1005	c.808T>A	c.(808-810)Tta>Ata	p.L270I	MSR1_ENST00000262101.5_Missense_Mutation_p.L270I|MSR1_ENST00000381998.4_Missense_Mutation_p.L270I|MSR1_ENST00000445506.2_Missense_Mutation_p.L288I|MSR1_ENST00000536385.1_Missense_Mutation_p.L44I|MSR1_ENST00000355282.2_Missense_Mutation_p.L270I	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	270					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCTTGAATTAAAGTGATATTT	0.303000													33	62					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105179417	105179417	+	Silent	SNP	C	C	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:105179417C>A	ENST00000369797.3	+	16	2323	c.2229C>A	c.(2227-2229)ggC>ggA	p.G743G		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	743	S1 motif 8.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		AGGACTATGGCGTGTTCATCC	0.493000													3	89					1	1	1	1	0
TCP11L2	255394	broad.mit.edu	37	12	106717367	106717367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr12:106717367C>T	ENST00000546625.1	+	6	874	c.715C>T	c.(715-717)Cgc>Tgc	p.R239C	TCP11L2_ENST00000299045.3_Missense_Mutation_p.R239C|TCP11L2_ENST00000552690.1_3'UTR|TCP11L2_ENST00000547153.1_Missense_Mutation_p.R239C			Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	239										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						GCACCTTCAACGCCAGTTGGT	0.338000													6	166					0	0	1	0	0
RANBP9	10048	broad.mit.edu	37	6	13711709	13711709	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr6:13711709G>T	ENST00000011619.3	-	1	87	c.29C>A	c.(28-30)cCg>cAg	p.P10Q		NM_005493.2	NP_005484.2	Q96S59	RANB9_HUMAN	RAN binding protein 9	10	Poly-Pro.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	16	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ctgctgctgcggcggcggcgg	0.761000													4	23					0.150653	0.156997	1	1	0
BCL11A	53335	broad.mit.edu	37	2	60688844	60688844	+	Silent	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:60688844G>A	ENST00000335712.6	-	4	1430	c.1203C>T	c.(1201-1203)ggC>ggT	p.G401G	BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000356842.4_Silent_p.G401G|BCL11A_ENST00000538214.1_Silent_p.G367G|BCL11A_ENST00000358510.4_Silent_p.G367G|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000537768.1_Silent_p.G70G	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	401					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			AGGGCTTCTCGCCCGTGTGGC	0.607000			T	IGH@	B-CLL								144	135					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79060511	79060511	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr15:79060511T>C	ENST00000388820.4	-	17	2819	c.2609A>G	c.(2608-2610)cAa>cGa	p.Q870R	ADAMTS7_ENST00000566303.1_5'UTR	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	870	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CTTCCTCTGTTGGTCATCAGG	0.692000													3	36					0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17406213	17406213	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr8:17406213T>C	ENST00000470360.1	+	6	796	c.679T>C	c.(679-681)Tct>Cct	p.S227P	SLC7A2_ENST00000398090.3_Missense_Mutation_p.S227P|SLC7A2_ENST00000004531.10_Missense_Mutation_p.S227P|SLC7A2_ENST00000522656.1_Missense_Mutation_p.S187P|SLC7A2_ENST00000494857.1_Missense_Mutation_p.S187P			P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	187					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	AGTAAAAGAGTCTGCTTGGGT	0.373000													76	155					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150527966	150527966	+	Silent	SNP	T	T	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:150527966T>C	ENST00000271643.4	+	8	1532	c.1296T>C	c.(1294-1296)cgT>cgC	p.R432R	RP11-54A4.2_ENST00000442435.2_RNA|ADAMTSL4_ENST00000369039.5_Silent_p.R455R|ADAMTSL4_ENST00000369041.5_Silent_p.R432R|ADAMTSL4_ENST00000369038.2_Silent_p.R432R	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	432					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TCTATGTCCGTCACACTGAAA	0.607000													14	87					0	0	1	0	0
TULP2	7288	broad.mit.edu	37	19	49398288	49398288	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:49398288G>A	ENST00000221399.3	-	6	625	c.481C>T	c.(481-483)Cga>Tga	p.R161*		NM_003323.2	NP_003314.2	O00295	TULP2_HUMAN	tubby like protein 2	161					visual perception	cytoplasm|extracellular region				NS(1)|breast(2)|central_nervous_system(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	22		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		CCCTTGCGTCGGATTCTCGGA	0.522000													24	92					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175214	57175214	+	Silent	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:57175214G>A	ENST00000537055.2	-	2	1584	c.1353C>T	c.(1351-1353)tgC>tgT	p.C451C		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						AGGCCTTGCCGCACTCGGGGC	0.672000													4	118					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62290231	62290231	+	Silent	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:62290231G>A	ENST00000258991.3	-	2	1431	c.1347C>T	c.(1345-1347)ctC>ctT	p.L449L	TEX2_ENST00000584379.1_Silent_p.L449L|TEX2_ENST00000583097.1_Silent_p.L449L			Q8IWB9	TEX2_HUMAN	testis expressed 2	449					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CATCTTCCGCGAGCACCTCTG	0.507000													66	230					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38407208	38407208	+	Silent	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:38407208C>T	ENST00000322350.5	+	8	1453	c.1107C>T	c.(1105-1107)tgC>tgT	p.C369C	EGFLAM_ENST00000336740.6_Silent_p.C135C|EGFLAM_ENST00000354891.3_Silent_p.C369C|EGFLAM_ENST00000397202.2_Intron	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	369	EGF-like 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GCTCGCGATGCCAGTGCACCC	0.552000													29	77					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186277987	186277987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:186277987C>T	ENST00000445192.2	+	7	3181	c.3136C>T	c.(3136-3138)Cca>Tca	p.P1046S	PRG4_ENST00000367485.4_Missense_Mutation_p.P953S|PRG4_ENST00000367484.3_Missense_Mutation_p.P575S|PRG4_ENST00000367486.3_Missense_Mutation_p.P1003S|PRG4_ENST00000367483.4_Missense_Mutation_p.P1005S	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	1046					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						AGTGAGAAAACCAAAGACGAC	0.448000													62	33					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164733006	164733006	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr3:164733006C>A	ENST00000264382.3	-	33	3966	c.3904G>T	c.(3904-3906)Gga>Tga	p.G1302*		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1302	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTTTCATTTCCTGAAATTGCT	0.348000										HNSCC(35;0.089)			34	32					1.36615e-20	1.50276e-20	1	1	0
ZNF737	100129842	broad.mit.edu	37	19	20728170	20728170	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:20728170G>C	ENST00000427401.4	-	4	933	c.839C>G	c.(838-840)aCt>aGt	p.T280S		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	280					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						TTTCTCTCCAGTATGAATTAT	0.413000													3	76					0	0	1	0	0
LCP1	3936	broad.mit.edu	37	13	46721149	46721149	+	Silent	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr13:46721149G>A	ENST00000398576.2	-	13	1456	c.1068C>T	c.(1066-1068)gtC>gtT	p.V356V	LCP1_ENST00000323076.2_Silent_p.V356V			P13796	PLSL_HUMAN	lymphocyte cytosolic protein 1 (L-plastin)	356	Actin-binding 1.|CH 2.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		GGTTCCCTCGGACAACATCTG	0.547000			T	BCL6	NHL								69	63					0	0	1	0	0
ABCD3	5825	broad.mit.edu	37	1	94884036	94884036	+	Translation_Start_Site	SNP	T	T	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:94884036T>A	ENST00000370214.4	+	1	26	c.2T>A	c.(1-3)aTg>aAg	p.M1K	ABCD3_ENST00000394233.2_Start_Codon_SNP_p.M1K|ABCD3_ENST00000315713.5_Start_Codon_SNP_p.M1K|ABCD3_ENST00000454898.2_Start_Codon_SNP_p.M1K|ABCD3_ENST00000536817.1_5'UTR	NM_002858.3	NP_002849.1	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D (ALD), member 3	1	Interaction with PEX19.|Targeting to peroxisomes.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(2)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		GGCAGTGCCATGGCGGCCTTC	0.726000													3	31					0	0	1	0	0
FBXO38	81545	broad.mit.edu	37	5	147820746	147820746	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:147820746C>T	ENST00000340253.5	+	21	3502	c.3334C>T	c.(3334-3336)Cga>Tga	p.R1112*	FBXO38_ENST00000296701.6_Nonsense_Mutation_p.R867*|FBXO38_ENST00000394370.3_Nonsense_Mutation_p.R1037*|FBXO38_ENST00000513826.1_Nonsense_Mutation_p.R867*			Q6PIJ6	FBX38_HUMAN	F-box protein 38	1112						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGTCATTACGAGCTGCAGA	0.438000													52	124					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544867	23544867	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:23544867T>C	ENST00000300619.7	-	4	1119	c.914A>G	c.(913-915)cAt>cGt	p.H305R	ZNF91_ENST00000397082.2_Missense_Mutation_p.H273R|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	305						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAATGGCTAAAAGC	0.413000													8	189					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90321631	90321631	+	Silent	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:90321631G>A	ENST00000469640.2	+	27	4095	c.3720G>A	c.(3718-3720)gtG>gtA	p.V1240V	DAPK1_ENST00000491893.1_Silent_p.V1149V|DAPK1_ENST00000472284.1_Silent_p.V1215V|DAPK1_ENST00000408954.3_Silent_p.V1215V|DAPK1_ENST00000358077.5_Silent_p.V1215V			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1215					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						TGGACTCGGTGTGCAGCACCA	0.642000									Chronic Lymphocytic Leukemia, Familial Clustering of				3	32					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169111328	169111328	+	Silent	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:169111328C>T	ENST00000256935.8	+	8	815	c.735C>T	c.(733-735)taC>taT	p.Y245Y		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	245					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTCTCTCTACGACCCCAACA	0.493000													66	198					0	0	1	0	0
LRRC45	201255	broad.mit.edu	37	17	79985969	79985969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:79985969G>A	ENST00000306688.3	+	9	1336	c.994G>A	c.(994-996)Gag>Aag	p.E332K		NM_144999.2	NP_659436.1	Q96CN5	LRC45_HUMAN	leucine rich repeat containing 45	332						centrosome				lung(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	5	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			AGCGGAGCAGGAGCAGCTGAG	0.682000													5	10					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													4	52					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396134	38396134	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:38396134C>A	ENST00000377698.3	+	2	542	c.389C>A	c.(388-390)cCt>cAt	p.P130H		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	130					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	AATGGGAAGCCTTTCCAAGAG	0.577000													80	262					4.82855e-46	5.55845e-46	1	1	0
DNA2	1763	broad.mit.edu	37	10	70182143	70182143	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:70182143G>T	ENST00000399180.2	-	17	2793	c.2794C>A	c.(2794-2796)Ctg>Atg	p.L932M	DNA2_ENST00000399179.2_Intron|DNA2_ENST00000358410.3_Missense_Mutation_p.L846M			P51530	DNA2L_HUMAN	DNA replication helicase/nuclease 2	846					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)	20						CCACACTCCAGCTTGCCCTCA	0.363000													3	62					1	1	1	1	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783741	149783741	+	Silent	SNP	C	C	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:149783741C>G	ENST00000427880.2	-	1	184	c.138G>C	c.(136-138)ctG>ctC	p.L46L	HIST2H2BF_ENST00000369167.1_Silent_p.L46L|HIST2H2BF_ENST00000545683.1_Silent_p.L46L|HIST2H2BF_ENST00000469483.1_5'UTR			Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf	46					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Breast(34;0.0124)|all_hematologic(923;0.127)					GGACCTGCTTCAGCACCTTGT	0.582000													271	387					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88477718	88477718	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:88477718T>A	ENST00000267549.3	+	2	1085	c.527T>A	c.(526-528)tTa>tAa	p.L176*	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	176					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						AAATACCCTTTAGAGAAATGG	0.408000													41	106					0	0	1	0	0
ZBTB43	23099	broad.mit.edu	37	9	129595533	129595533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:129595533G>A	ENST00000373464.4	+	3	1009	c.745G>A	c.(745-747)Gag>Aag	p.E249K	ZBTB43_ENST00000373457.1_Missense_Mutation_p.E249K|ZBTB43_ENST00000449886.1_Missense_Mutation_p.E249K	NM_014007.3	NP_054726.1	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						CGTGAAGCCCGAGCGCTTAGA	0.617000													18	6					0	0	1	0	0
AATF	26574	broad.mit.edu	37	17	35348139	35348139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:35348139G>A	ENST00000225402.5	+	8	1632	c.1381G>A	c.(1381-1383)Gat>Aat	p.D461N		NM_012138.3	NP_036270.1	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	461	RB1 and SP1 binding.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)	18		Breast(25;0.00607)				CTTTGATGATGATGACTTTTA	0.373000													38	77					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936915	15936915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:15936915G>A	ENST00000504595.1	+	4	1577	c.1096G>A	c.(1096-1098)Gtg>Atg	p.V366M	FBXL7_ENST00000329673.7_Missense_Mutation_p.V354M|FBXL7_ENST00000510662.1_Missense_Mutation_p.V319M	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	366					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GGTCACCGACGTGGGCATCCG	0.672000													4	34					0	0	1	0	0
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81443821	81443821	+	RNA	SNP	C	C	G	rs150975459	by1000genomes	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:81443821C>G	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							GCAGCACCATCGCCTCAGACC	0.612000													6	43					0	0	1	0	0
ZNF71	58491	broad.mit.edu	37	19	57132975	57132975	+	Missense_Mutation	SNP	G	G	A	rs139335499		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:57132975G>A	ENST00000328070.6	+	3	554	c.320G>A	c.(319-321)cGt>cAt	p.R107H		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	107						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		CCCGTAAGGCGTGGCAAGAAC	0.582000													19	94					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126329750	126329750	+	Silent	SNP	A	A	G	rs145529167		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr4:126329750A>G	ENST00000394329.3	+	4	5734	c.5721A>G	c.(5719-5721)gaA>gaG	p.E1907E	FAT4_ENST00000335110.5_Silent_p.E205E	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1907	Cadherin 18.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TAGATTATGAAGTACAGCAAT	0.328000													52	33					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47395831	47395831	+	Missense_Mutation	SNP	G	G	A	rs58897090		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:47395831G>A	ENST00000310638.4	-	12	1547	c.1516C>T	c.(1516-1518)Ctc>Ttc	p.L506F	CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371904.4_Missense_Mutation_p.L507F	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	506			NGIHLRLRRLPNPCEDKDQL -> MESTCVSGGSLTLVKTR TSFEGLHLPSCLPDPRFCPLPVCPYPVFCLPTFPSSHLPAV PQSACPSLSHLSPGLPTCLSTCLLPTCISCWEKS (in CYP4A11V).		long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	AGCCTCCTGAGACGCAGGTGG	0.577000													5	87					0	0	1	0	0
NSA2	10412	broad.mit.edu	37	5	74072447	74072447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:74072447C>T	ENST00000296802.5	+	6	1103	c.734C>T	c.(733-735)aCc>aTc	p.T245I		NM_014886.3	NP_055701.1	O95478	NSA2_HUMAN	NSA2 ribosome biogenesis homolog (S. cerevisiae)	245					rRNA processing	nucleolus|ribonucleoprotein complex				breast(1)|endometrium(2)|kidney(1)|lung(1)|ovary(1)|skin(1)	7						GCCCAGGTTACCAACAATCCT	0.318000													96	127					0	0	1	0	0
ACOT4	122970	broad.mit.edu	37	14	74059007	74059007	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:74059007A>G	ENST00000326303.4	+	1	598	c.344A>G	c.(343-345)gAg>gGg	p.E115G		NM_152331.3	NP_689544.3	Q8N9L9	ACOT4_HUMAN	acyl-CoA thioesterase 4	115					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(234;0.00331)		CACGACCCCGAGCCTGGACGG	0.692000													9	20					0	0	1	0	0
SGCA	6442	broad.mit.edu	37	17	48246488	48246488	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:48246488C>G	ENST00000262018.3	+	6	656	c.620C>G	c.(619-621)tCt>tGt	p.S207C	SGCA_ENST00000513942.1_Intron|SGCA_ENST00000344627.6_Intron|SGCA_ENST00000451235.2_Missense_Mutation_p.S105C|SGCA_ENST00000543315.1_Intron	NM_000023.2	NP_000014.1	Q16586	SGCA_HUMAN	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	207					muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(2)|skin(1)	14						TCACCTTTTTCTACTTGCCTG	0.592000											OREG0024558	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	67	89					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109734382	109734382	+	Missense_Mutation	SNP	C	C	T	rs41279692		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:109734382C>T	ENST00000369939.3	+	13	1763	c.1580C>T	c.(1579-1581)aCg>aTg	p.T527M	KIAA1324_ENST00000369938.1_3'UTR|KIAA1324_ENST00000529753.1_Missense_Mutation_p.T440M	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	527					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CCTGTGGAGACGTGGAAAGGT	0.537000													134	23					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83346082	83346082	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr15:83346082G>C	ENST00000261722.3	-	13	1639	c.1432C>G	c.(1432-1434)Cca>Gca	p.P478A	AP3B2_ENST00000535359.1_Missense_Mutation_p.P478A|AP3B2_ENST00000535348.1_Missense_Mutation_p.P446A|RP11-752G15.3_ENST00000560650.1_RNA	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	478					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			TGTTGTGCTGGCTGCATCTGT	0.478000													6	40					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176860178	176860178	+	Silent	SNP	T	T	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:176860178T>C	ENST00000355472.5	+	6	639	c.471T>C	c.(469-471)ccT>ccC	p.P157P	GRK6_ENST00000355958.5_Silent_p.P157P|GRK6_ENST00000528793.1_Silent_p.P157P|GRK6_ENST00000393576.3_Silent_p.P157P|GRK6_ENST00000507633.1_Silent_p.P157P	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	157	N-terminal.|RGS.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCGTGGCCCCTTTTGCCGACT	0.627000													4	236					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164785	139164785	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr8:139164785T>G	ENST00000395297.1	-	13	2103	c.1933A>C	c.(1933-1935)Agt>Cgt	p.S645R		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	645										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGGGTAGAACTTAGTGGATCA	0.488000										HNSCC(54;0.14)			41	111					0	0	1	0	0
PACS1	55690	broad.mit.edu	37	11	65983735	65983735	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr11:65983735G>A	ENST00000320580.4	+	5	838		c.e5+1			NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1						interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						AAGCTTTCTGGTAAGAAGCAT	0.498000													6	44					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201195105	201195105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:201195105C>T	ENST00000335211.4	+	22	10770	c.10640C>T	c.(10639-10641)gCa>gTa	p.A3547V	IGFN1_ENST00000295591.8_3'UTR	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TGGCACGAGGCAGCCGACCGC	0.667000													18	84					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79060510	79060510	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr15:79060510T>G	ENST00000388820.4	-	17	2820	c.2610A>C	c.(2608-2610)caA>caC	p.Q870H	ADAMTS7_ENST00000566303.1_5'UTR	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	870	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						ACTTCCTCTGTTGGTCATCAG	0.697000													3	36					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1232963	1232963	+	Silent	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:1232963G>A	ENST00000324642.3	+	3	522	c.399G>A	c.(397-399)ccG>ccA	p.P133P	SLC6A18_ENST00000296821.4_Silent_p.P133P	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	133					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCCAGCACCCGCTGCCCTGGA	0.642000													48	203					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													3	144					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101348096	101348096	+	Silent	SNP	G	G	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:101348096G>A	ENST00000534062.1	-	1	3088	c.3030C>T	c.(3028-3030)gcC>gcT	p.A1010A		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	1010										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						TTTGCCTGGCGGCAGTGTTCC	0.577000													11	4					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76528954	76528954	+	Missense_Mutation	SNP	G	G	A	rs138136389	byFrequency	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr16:76528954G>A	ENST00000307431.8	+	15	2610	c.2225G>A	c.(2224-2226)cGg>cAg	p.R742Q	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.R670Q|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.R746Q|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.R694Q|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	743	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GATGCTGACCGGAATGAATGG	0.358000													50	88					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163059576	163059576	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:163059576T>C	ENST00000188790.4	-	13	1334	c.1127A>G	c.(1126-1128)cAt>cGt	p.H376R	FAP_ENST00000443424.1_Missense_Mutation_p.H351R	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	376					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						ATAGTGAATATGTTTGTAGCC	0.363000													24	34					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21217066	21217066	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:21217066A>T	ENST00000380216.1	-	1	244	c.239T>A	c.(238-240)tTc>tAc	p.F80Y		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	80					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		CATCTCATGGAAGGCAGAGAT	0.468000													115	14					0	0	1	0	0
SLC16A12	387700	broad.mit.edu	37	10	91198576	91198576	+	Silent	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:91198576C>T	ENST00000341233.4	-	6	1113	c.723G>A	c.(721-723)ttG>ttA	p.L241L	SLC16A12_ENST00000371790.4_Silent_p.L271L	NM_213606.3	NP_998771.3	Q6ZSM3	MOT12_HUMAN	solute carrier family 16, member 12	241						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						ACTCTTGCTGCAAACAGCAAC	0.448000													36	9					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76797597	76797597	+	Missense_Mutation	SNP	C	C	T	rs140029551	byFrequency	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr4:76797597C>T	ENST00000286719.7	-	11	1519	c.1163G>A	c.(1162-1164)cGg>cAg	p.R388Q		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	388	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CCGCACCTGCCGGGAGAGCTC	0.672000													17	39					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88442747	88442747	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:88442747G>T	ENST00000261304.2	-	7	813	c.707C>A	c.(706-708)tCc>tAc	p.S236Y	GALC_ENST00000393568.4_Missense_Mutation_p.S213Y|GALC_ENST00000393569.2_Missense_Mutation_p.S210Y|GALC_ENST00000554916.1_5'UTR|GALC_ENST00000544807.2_Missense_Mutation_p.S180Y	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	236					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AAGGAGCATGGATGCAGAGAT	0.398000													66	47					3.26865e-45	3.71949e-45	1	1	0
FDXR	2232	broad.mit.edu	37	17	72863050	72863050	+	Silent	SNP	C	C	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:72863050C>T	ENST00000442102.2	-	3	341	c.255G>A	c.(253-255)gcG>gcA	p.A85A	FDXR_ENST00000582944.1_Intron|FDXR_ENST00000544854.1_Intron|FDXR_ENST00000455107.2_Intron|FDXR_ENST00000420580.2_Intron|FDXR_ENST00000581969.1_Intron|FDXR_ENST00000581530.1_Intron|FDXR_ENST00000583917.1_Intron|FDXR_ENST00000293195.5_Intron|FDXR_ENST00000413947.2_Intron	NM_001258012.1	NP_001244941.1	P22570	ADRO_HUMAN	ferredoxin reductase	59					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					GAGGCTGGGACGCCCCCAGGT	0.622000													5	11					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													4	32					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23701589	23701589	+	Silent	SNP	A	A	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:23701589A>G	ENST00000397312.2	-	5	775	c.501T>C	c.(499-501)ggT>ggC	p.G167G	ELAVL2_ENST00000380110.4_Silent_p.G196G|ELAVL2_ENST00000380117.1_Silent_p.G167G|ELAVL2_ENST00000223951.6_Silent_p.G167G|ELAVL2_ENST00000544538.1_Silent_p.G167G	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	167	RRM 2.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TAAACCCTACACCCCTTGATA	0.438000													5	107					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25145722	25145722	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr22:25145722T>C	ENST00000332271.5	-	10	1570	c.1154A>G	c.(1153-1155)aAg>aGg	p.K385R	PIWIL3_ENST00000533313.1_Missense_Mutation_p.K276R|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.K276R	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	385	PAZ.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CGTTAGGCCCTTTTTCCATCT	0.468000													3	109					0	0	1	0	0
PCP4L1	654790	broad.mit.edu	37	1	161254154	161254156	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:161254154_161254156delGGA	ENST00000504449.1	+	3	338_340	c.90_92delGGA	c.(88-93)gcg>gc	p.AE30del		NM_001102566.1	NP_001096036.1	A6NKN8	PC4L1_HUMAN	Purkinje cell protein 4 like 1	30								p.A30A(1)|p.E35delE(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	all_cancers(52;4.16e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TCAAGAAGGCGGAGGAGGAGGAG	0.488													8	382	---	---	---	---					
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	GACGGG	-	rs112040677		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:131129929_131129934delGACGGG	ENST00000175756.5	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)cag>ca	p.QTG371del	PTPN18_ENST00000347849.3_In_Frame_Del_p.QTG264del	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	371						cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity	p.T378_G379delTG(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.777													3	4	---	---	---	---					
VCAN	1462	broad.mit.edu	37	5	82816057	82816057	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:82816057delT	ENST00000265077.3	+	7	2497	c.1932delT	c.(1930-1932)ccfs	p.P644fs	VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000342785.4_Frame_Shift_Del_p.P644fs|VCAN_ENST00000512590.2_Frame_Shift_Del_p.P596fs	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	644	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CTACTACACCTTTTCCATCAC	0.368													8	849	---	---	---	---					
PTEN	5728	broad.mit.edu	37	10	89693002	89693003	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:89693002_89693003insA	ENST00000371953.3	+	5	1843_1844	c.486_487insA	c.(484-489)gaaaaafs	p.EK162fs		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	162	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.K163*(2)|p.Y27fs*1(2)|p.F56fs*2(1)|p.D162fs*8(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGACCAGAGACAAAAAGGTAAG	0.351		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			43	8	---	---	---	---					
HPS1	3257	broad.mit.edu	37	10	100186987	100186987	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:100186987delG	ENST00000325103.6	-	11	1205	c.972delC	c.(970-972)ccfs	p.P324fs	HPS1_ENST00000361490.4_Frame_Shift_Del_p.P324fs|HPS1_ENST00000467246.1_5'UTR	NM_000195.3	NP_000186.2	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1	324					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity	p.M325fs*128(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		GGGCATCCATGGGGGGGGTGC	0.572									Hermansky-Pudlak syndrome				2	4	---	---	---	---					
RP11-789A21.1	0	broad.mit.edu	37	14	85671210	85671210	+	RNA	DEL	G	G	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:85671210delG	ENST00000556016.1	-	0	209																											cactccctctggggcttcggg	0.572													2	4	---	---	---	---					
ZCCHC14	23174	broad.mit.edu	37	16	87445976	87445979	+	Frame_Shift_Del	DEL	GCAG	GCAG	-	rs143691635		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr16:87445976_87445979delGCAG	ENST00000268616.4	-	12	2154_2157	c.1937_1940delCTGC	c.(1936-1941)ctfs	p.PA646fs		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	646					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GGCAGAATCAGCAGGAACAGATGA	0.583													73	325	---	---	---	---					
FANCA	2175	broad.mit.edu	37	16	89806404	89806405	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr16:89806404_89806405delCT	ENST00000389301.3	-	39	3961_3962	c.3931_3932delAG	c.(3931-3933)tfs	p.S1311fs	FANCA_ENST00000568369.1_Frame_Shift_Del_p.S1311fs|ZNF276_ENST00000289816.5_3'UTR	NM_000135.2	NP_000126.2	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A	1311					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			breast(5)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|urinary_tract(3)	47		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		TTTCTTACCACTCTCTGTCAAC	0.510			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				70	214	---	---	---	---					
MYO1C	4641	broad.mit.edu	37	17	1378283	1378284	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:1378283_1378284insT	ENST00000359786.5	-	15	1941_1942	c.1617_1618insA	c.(1615-1620)cggggafs	p.RG539fs	MYO1C_ENST00000545534.2_Frame_Shift_Ins_p.RG515fs|MYO1C_ENST00000575158.1_Frame_Shift_Ins_p.RG504fs|MYO1C_ENST00000438665.2_Frame_Shift_Ins_p.RG520fs|MYO1C_ENST00000361007.2_Frame_Shift_Ins_p.RG504fs	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	539	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CGGAATTCCCCTCGGCCCAGAG	0.668													2	4	---	---	---	---					
DNAH9	1770	broad.mit.edu	37	17	11837333	11837333	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:11837333delC	ENST00000262442.3	+	65	12502	c.12434delC	c.(12433-12435)ttfs	p.S4145fs	DNAH9_ENST00000396001.2_Frame_Shift_Del_p.S457fs|DNAH9_ENST00000454412.2_Frame_Shift_Del_p.S4069fs	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4145					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGAGAACTGTCTTTGGCCCCA	0.502													73	147	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29553542	29553542	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:29553542delC	ENST00000358273.4	+	18	2474	c.2091delC	c.(2089-2091)aafs	p.N697fs	NF1_ENST00000356175.3_Frame_Shift_Del_p.N697fs	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	697					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTCTGTGGAACCCTGACACTG	0.542			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			113	44	---	---	---	---					
GATA6	2627	broad.mit.edu	37	18	19752073	19752075	+	In_Frame_Del	DEL	ACC	ACC	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr18:19752073_19752075delACC	ENST00000269216.3	+	2	1245_1247	c.968_970delACC	c.(967-972)tac>t	p.YH323del	GATA6_ENST00000581694.1_In_Frame_Del_p.YH323del	NM_005257.4	NP_005248.2	Q92908	GATA6_HUMAN	GATA binding protein 6	323					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			AACGGGACGTaccaccaccacca	0.749													2	4	---	---	---	---					
NUCB1	4924	broad.mit.edu	37	19	49425109	49425111	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:49425109_49425111delAGC	ENST00000405315.4	+	12	1533_1535	c.1199_1201delAGC	c.(1198-1203)aag>a	p.KQ400del	NUCB1_ENST00000263273.5_In_Frame_Del_p.KQ400del|NUCB1_ENST00000407032.1_In_Frame_Del_p.KQ400del|NUCB1_ENST00000485798.1_3'UTR	NM_006184.5	NP_006175.2	Q02818	NUCB1_HUMAN	nucleobindin 1	400						ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding			cervix(1)|endometrium(4)|large_intestine(4)|lung(8)	17		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		Gagcagcggaagcagcagcagca	0.640													8	155	---	---	---	---					
MICAL3	57553	broad.mit.edu	37	22	18314825	18314827	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr22:18314825_18314827delCTC	ENST00000441493.2	-	21	3200_3202	c.2848_2850delGAG	c.(2848-2850)del	p.E950del		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	950	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		GCAGGCGAGGctcctcctcctcc	0.557													7	41	---	---	---	---					
