Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
INPP4B	8821	broad.mit.edu	37	4	143350350	143350350	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:143350350C>T	ENST00000513000.1	-	6	545	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	INPP4B_ENST00000262992.4_Missense_Mutation_p.E38K|INPP4B_ENST00000308502.4_Missense_Mutation_p.E38K|INPP4B_ENST00000507861.1_Missense_Mutation_p.E38K|INPP4B_ENST00000506217.1_Missense_Mutation_p.E38K|INPP4B_ENST00000509777.1_Missense_Mutation_p.E38K|INPP4B_ENST00000508116.1_Missense_Mutation_p.E38K	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	38	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					AACTGCGGTTCATTTGGAGTC	0.274000													3	9					0	0	0.009096	0	0
FAM83B	222584	broad.mit.edu	37	6	54806613	54806613	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:54806613G>A	ENST00000306858.7	+	5	2960	c.2844G>A	c.(2842-2844)caG>caA	p.Q948Q		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	948										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					GCTCTATTCAGCCAACAAGCA	0.438000													13	74					0	0	0.001855	0	0
TRPM6	140803	broad.mit.edu	37	9	77377921	77377921	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:77377921C>T	ENST00000451710.3	-	26	3903	c.3666G>A	c.(3664-3666)ctG>ctA	p.L1222L	TRPM6_ENST00000361255.3_Silent_p.L1217L|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376864.4_Silent_p.L1222L|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000360774.1_Silent_p.L1222L|TRPM6_ENST00000449912.2_Silent_p.L1217L			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1222					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						AAAGGACTTTCAGGGTATCCA	0.473000													14	68					0	0	0.006122	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316491	30316491	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:30316491A>T	ENST00000375377.1	-	3	2687	c.2586T>A	c.(2584-2586)agT>agA	p.S862R		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	862	Ser-rich.									breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						GCTCCGCCTCACTCTCCTCAc	0.567000													19	66					0	0	0.007413	0	0
KLHL4	56062	broad.mit.edu	37	X	86869550	86869550	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:86869550C>T	ENST00000373119.4	+	3	849	c.704C>T	c.(703-705)tCc>tTc	p.S235F	KLHL4_ENST00000373114.4_Missense_Mutation_p.S235F	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	235	BTB.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						GCACTAAATTCCTTGGTGCAG	0.363000													6	9					0	0	0.001984	0	0
ANK3	288	broad.mit.edu	37	10	62038626	62038626	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:62038626C>T	ENST00000280772.1	-	4	511	c.320G>A	c.(319-321)gGa>gAa	p.G107E	ANK3_ENST00000373827.2_Missense_Mutation_p.G101E|ANK3_ENST00000503366.1_Missense_Mutation_p.G90E	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	107					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGCTGTGTTTCCTTTCTGTGA	0.388000													17	95					0	0	0.004990	0	0
TBXAS1	6916	broad.mit.edu	37	7	139657436	139657436	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:139657436C>T	ENST00000263552.6	+	12	1233	c.695C>T	c.(694-696)tCa>tTa	p.S232L	TBXAS1_ENST00000416849.2_Missense_Mutation_p.S278L|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000414508.2_Missense_Mutation_p.S232L|TBXAS1_ENST00000458722.1_Missense_Mutation_p.S277L|TBXAS1_ENST00000436047.2_Missense_Mutation_p.S232L|TBXAS1_ENST00000425687.1_Missense_Mutation_p.S164L|TBXAS1_ENST00000411653.1_Missense_Mutation_p.S231L|TBXAS1_ENST00000336425.5_Missense_Mutation_p.S231L|TBXAS1_ENST00000448866.1_Missense_Mutation_p.S231L	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	231					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					TTTCAAGTATCATTTCCATCC	0.453000													34	49					0	0	0.004289	0	0
FRAS1	80144	broad.mit.edu	37	4	79236774	79236774	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:79236774G>A	ENST00000264895.6	+	16	2145	c.1705G>A	c.(1705-1707)Ggc>Agc	p.G569S	FRAS1_ENST00000325942.6_Missense_Mutation_p.G569S|FRAS1_ENST00000264899.6_Missense_Mutation_p.G569S	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	569					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGACAGTTGTGGCCCCAGTAG	0.488000													21	114					0	0	0.014323	0	0
ANKEF1	63926	broad.mit.edu	37	20	10036182	10036182	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:10036182G>A	ENST00000378380.3	+	10	2534	c.2205G>A	c.(2203-2205)ctG>ctA	p.L735L	ANKEF1_ENST00000488991.1_3'UTR|SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000603542.1_RNA|ANKEF1_ENST00000378392.1_Silent_p.L735L	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		CAGCAGAGCTGATCAGGAAGA	0.438000													7	31					0	0	0.003080	0	0
CSMD1	64478	broad.mit.edu	37	8	2830798	2830798	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:2830798C>T	ENST00000520002.1	-	58	9322	c.8767G>A	c.(8767-8769)Gat>Aat	p.D2923N	CSMD1_ENST00000602723.1_Missense_Mutation_p.D2865N|CSMD1_ENST00000400186.3_Missense_Mutation_p.D2865N|CSMD1_ENST00000602557.1_Missense_Mutation_p.D2923N|CSMD1_ENST00000542608.1_Missense_Mutation_p.D2864N|CSMD1_ENST00000537824.1_Missense_Mutation_p.D2922N			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2923	Sushi 22.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTCCCCGGATCACCACAGAAT	0.463000													26	163					0	0	0.005443	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955376	18955376	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:18955376C>T	ENST00000302797.3	-	1	1180	c.956G>A	c.(955-957)aGa>aAa	p.R319K		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	319					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CTGCTCCAATCTGCTTCCCGA	0.547000													10	88					0	0	0.010729	0	0
DSP	1832	broad.mit.edu	37	6	7585382	7585382	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:7585382G>A	ENST00000379802.3	+	24	8228	c.7887G>A	c.(7885-7887)gaG>gaA	p.E2629E	DSP_ENST00000418664.2_Silent_p.E2030E	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2629	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAAACCTGGAGAAAATCTCCA	0.512000													16	135					0	0	0.004990	0	0
ZAN	7455	broad.mit.edu	37	7	100386863	100386863	+	RNA	SNP	C	C	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:100386863C>G	ENST00000542585.1	+	0	7396				ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGATGGCCGTCCCCTACAGGC	0.567000													5	54					0	0	0.001168	0	0
FLRT2	23768	broad.mit.edu	37	14	86089039	86089039	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:86089039G>A	ENST00000330753.4	+	2	1948	c.1181G>A	c.(1180-1182)aGc>aAc	p.S394N	FLRT2_ENST00000554746.1_Missense_Mutation_p.S394N	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	394					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CCTAGCAGAAGCTACACGCCT	0.577000													18	54					0	0	0.004990	0	0
KIAA1804	84451	broad.mit.edu	37	1	233482265	233482265	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:233482265G>A	ENST00000366624.3	+	2	1144	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	MLK4_ENST00000366623.3_Missense_Mutation_p.E295K	NM_032435.2	NP_115811.2																					GTTGGCGAGGGAATGGCACAG	0.433000													6	30					0	0	0.001168	0	0
CASP10	843	broad.mit.edu	37	2	202074214	202074214	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:202074214C>T	ENST00000286186.6	+	9	1779	c.1344C>T	c.(1342-1344)tcC>tcT	p.S448S	CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000272879.5_Silent_p.S448S|CASP10_ENST00000346817.5_Silent_p.S405S|CASP10_ENST00000448480.1_Silent_p.S405S|CASP10_ENST00000360132.3_3'UTR|CASP10_ENST00000313728.7_Silent_p.S381S	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	448					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						GCTATGTATCCTTTCGGCATG	0.498000													23	92					0	0	0.002780	0	0
OR2A12	346525	broad.mit.edu	37	7	143792319	143792319	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:143792319G>A	ENST00000408949.2	+	1	179	c.119G>A	c.(118-120)gGa>gAa	p.G40E		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					ACCCTGATGGGAAATGGGATT	0.493000													14	73					0	0	0.004007	0	0
CXCL6	6372	broad.mit.edu	37	4	74702545	74702545	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:74702545C>T	ENST00000226317.5	+	1	332	c.78C>T	c.(76-78)ctC>ctT	p.L26L	CXCL6_ENST00000515050.1_Silent_p.L26L	NM_002993.3	NP_002984.1	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6	26					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			large_intestine(1)|lung(7)	8	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CGCTGCTGCTCCTGCTGACGC	0.721000													7	23					0	0	0.001984	0	0
DSC1	1823	broad.mit.edu	37	18	28710560	28710560	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:28710560G>A	ENST00000257198.5	-	16	2863	c.2602C>T	c.(2602-2604)Cgg>Tgg	p.R868W	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257197.3_3'UTR	NM_024421.2	NP_077739.1	Q08554	DSC1_HUMAN	desmocollin 1	868					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TCTTCCTGCCGATCGCTGCAG	0.433000													16	93					0	0	0.008871	0	0
LPA	4018	broad.mit.edu	37	6	161027540	161027540	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:161027540C>T	ENST00000447678.1	-	18	2874	c.2754G>A	c.(2752-2754)ccG>ccA	p.P918P	LPA_ENST00000316300.5_Silent_p.P918P	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3426	Kringle 8.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GGCTTGGAATCGGGGTAATAG	0.527000													20	121					0	0	0.003954	0	0
BCAN	63827	broad.mit.edu	37	1	156622522	156622522	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:156622522C>T	ENST00000329117.4	+	8	2116	c.1780C>T	c.(1780-1782)Ctg>Ttg	p.L594L	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000361588.5_Silent_p.L594L	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	594					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGCCCCTTCCCTGCTTCCAGC	0.637000													16	39					0	0	0.004007	0	0
DAB2	1601	broad.mit.edu	37	5	39377003	39377003	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:39377003G>A	ENST00000545653.1	-	11	2353	c.1823C>T	c.(1822-1824)cCc>cTc	p.P608L	DAB2_ENST00000339788.6_Missense_Mutation_p.P411L|DAB2_ENST00000320816.6_Missense_Mutation_p.P629L|DAB2_ENST00000509337.1_Missense_Mutation_p.P608L	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	629					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GATGTCCTTGGGAGGGCCAGC	0.527000											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	123					0	0	0.005443	0	0
COL6A3	1293	broad.mit.edu	37	2	238275864	238275864	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:238275864G>A	ENST00000295550.4	-	11	5418	c.4966C>T	c.(4966-4968)Cag>Tag	p.Q1656*	COL6A3_ENST00000346358.4_Nonsense_Mutation_p.Q1456*|COL6A3_ENST00000409809.1_Nonsense_Mutation_p.Q1450*|COL6A3_ENST00000353578.4_Nonsense_Mutation_p.Q1450*|COL6A3_ENST00000347401.3_Nonsense_Mutation_p.Q1455*|COL6A3_ENST00000472056.1_Nonsense_Mutation_p.Q1049*	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1656	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGCACTTCCTGGAAACTGTCC	0.438000													5	33					0	0	0.001168	0	0
PNPLA7	375775	broad.mit.edu	37	9	140379138	140379138	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:140379138G>A	ENST00000406427.1	-	21	2584	c.2248C>T	c.(2248-2250)Ccg>Tcg	p.P750S	PNPLA7_ENST00000371457.1_Missense_Mutation_p.P331S|PNPLA7_ENST00000277531.4_Missense_Mutation_p.P725S	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	725					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TTGACAGCCGGGTTCCCCAAG	0.662000													4	18					0	0	0.009096	0	0
MIR3654	100500804	broad.mit.edu	37	11	62344694	62344694	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:62344694C>T	ENST00000496634.2	-	6	1275	c.1230G>A	c.(1228-1230)gtG>gtA	p.V410V	TUT1_ENST00000308436.7_Silent_p.V448V|TUT1_ENST00000476907.1_Silent_p.V410V																NS(1)	1						GGAGGGTGTACACGAGGGGCC	0.607000													13	55					0	0	0.002450	0	0
LPAR4	2846	broad.mit.edu	37	X	78010822	78010822	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:78010822G>A	ENST00000435339.2	+	2	861	c.456G>A	c.(454-456)agG>agA	p.R152R	LPAR4_ENST00000373301.2_Silent_p.R152R	NM_005296.2	NP_005287.1	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	152						integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						TTAGGACTAGGAGGAATTCTG	0.453000													17	18					0	0	0.004990	0	0
TRHDE	29953	broad.mit.edu	37	12	73012725	73012725	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:73012725G>A	ENST00000261180.4	+	13	2337	c.2241G>A	c.(2239-2241)gaG>gaA	p.E747E	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	747					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						ACCTGTCTGAGGAGAAGGATT	0.388000													12	60					0	0	0.010729	0	0
MPP7	143098	broad.mit.edu	37	10	28413025	28413025	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:28413025C>T	ENST00000337532.5	-	9	826	c.550G>A	c.(550-552)Gaa>Aaa	p.E184K	MPP7_ENST00000375732.1_Missense_Mutation_p.E184K|MPP7_ENST00000481244.1_5'UTR|MPP7_ENST00000445954.2_Missense_Mutation_p.E59K|MPP7_ENST00000540098.1_Missense_Mutation_p.E184K|MPP7_ENST00000375719.3_Missense_Mutation_p.E184K	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	184	PDZ.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						TCCCTAAGTTCATCACCAACA	0.358000													22	87					0	0	0.003330	0	0
GRIN2B	2904	broad.mit.edu	37	12	13715915	13715915	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:13715915C>T	ENST00000279593.3	-	13	4466	c.4257G>A	c.(4255-4257)ccG>ccA	p.P1419P		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1419					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCCGGAAGTCCGGCCTGGCTT	0.612000													9	38					0	0	0.004482	0	0
DHFRL1	200895	broad.mit.edu	37	3	93780104	93780104	+	Silent	SNP	T	T	A	rs148600595		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:93780104T>A	ENST00000394221.2	-	2	701	c.252A>T	c.(250-252)ccA>ccT	p.P84P	DHFRL1_ENST00000314636.2_Silent_p.P84P|DHFRL1_ENST00000481631.1_Intron	NM_001195643.1	NP_001182572.1	Q86XF0	DYRL1_HUMAN	dihydrofolate reductase-like 1	84	DHFR.				glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process		dihydrofolate reductase activity|NADP binding			kidney(1)|large_intestine(2)|lung(3)|skin(1)|stomach(1)	8						GAGCTCCTTGTGGAGGTTCCT	0.393000													23	74					0	0	0.012319	0	0
ANKS1A	23294	broad.mit.edu	37	6	34949593	34949593	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:34949593C>T	ENST00000360359.3	+	4	700	c.562C>T	c.(562-564)Ctg>Ttg	p.L188L	ANKS1A_ENST00000535627.1_Silent_p.L188L	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	188						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						CCCTTTGGACCTGGCAGCACT	0.557000													18	97					0	0	0.010504	0	0
BMX	660	broad.mit.edu	37	X	15574231	15574231	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:15574231G>A	ENST00000357607.2	+	19	2177	c.1989G>A	c.(1987-1989)ctG>ctA	p.L663L	BMX_ENST00000348343.6_Silent_p.L663L|BMX_ENST00000342014.6_Silent_p.L663L			P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	663	Protein kinase.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(14)|ovary(2)|urinary_tract(3)	30	Hepatocellular(33;0.183)					AGCAACTCCTGTCTTCCATTG	0.358000													37	57					0	0	0.013114	0	0
SRSF7	6432	broad.mit.edu	37	2	38977196	38977196	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:38977196G>A	ENST00000313117.6	-	2	406	c.169C>T	c.(169-171)Cct>Tct	p.P57S	SRSF7_ENST00000446327.2_Missense_Mutation_p.P57S|SRSF7_ENST00000409276.1_Missense_Mutation_p.P57S	NM_001031684.2|NM_001195446.1	NP_001026854.1|NP_001182375.1	Q16629	SRSF7_HUMAN	serine/arginine-rich splicing factor 7	57	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						GCATCTCTAGGATCTTCGAAT	0.383000													23	72					0	0	0.004656	0	0
OR1S2	219958	broad.mit.edu	37	11	57971483	57971483	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:57971483G>A	ENST00000302592.6	-	1	170	c.171C>T	c.(169-171)ctC>ctT	p.L57L		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				CCACAATGATGAGCCCGTTCC	0.458000													10	70					0	0	0.008291	0	0
TRAV13-2	28670	broad.mit.edu	37	14	22386380	22386380	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:22386380C>T	ENST00000390439.2	+	0	18																											GGAAGTAGCTCTTATGGCTGG	0.428000													14	65					0	0	0.003163	0	0
UBQLN3	50613	broad.mit.edu	37	11	5530452	5530452	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:5530452T>C	ENST00000311659.4	-	2	484	c.337A>G	c.(337-339)Agt>Ggt	p.S113G	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	113										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATCCAGGACTTGGGCCCTGG	0.612000													12	53					0	0	0.001855	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368261	86368261	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:86368261C>T	ENST00000400286.2	-	2	2981	c.2383G>A	c.(2383-2385)Gaa>Aaa	p.E795K		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	795						integral to membrane		p.E795K(1)		breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TTCAGCTCTTCGTGGGCTCCA	0.393000													33	68					0	0	0.013726	0	0
DOCK8	81704	broad.mit.edu	37	9	334291	334291	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:334291C>T	ENST00000432829.2	+	11	1304	c.988C>T	c.(988-990)Cgg>Tgg	p.R330W	DOCK8_ENST00000453981.1_Missense_Mutation_p.R398W|DOCK8_ENST00000469391.1_Missense_Mutation_p.R330W	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	398	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GGGGAAATACCGGATGCCCTT	0.443000													9	70					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179616325	179616325	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:179616325C>T	ENST00000360870.5	-	46	11024	c.10802G>A	c.(10801-10803)gGg>gAg	p.G3601E	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000578746.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3596							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCATCTTGCCCTTTTTGGAT	0.383000													15	104					0	0	0.003163	0	0
NLRP8	126205	broad.mit.edu	37	19	56466752	56466752	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:56466752C>T	ENST00000291971.3	+	3	1399	c.1328C>T	c.(1327-1329)tCc>tTc	p.S443F	NLRP8_ENST00000590542.1_Missense_Mutation_p.S443F	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	443	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGAACTTTTCCAGAAAGATC	0.473000													19	83					0	0	0.012319	0	0
IGHV3-13	28449	broad.mit.edu	37	14	106586347	106586347	+	RNA	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:106586347G>A	ENST00000390602.2	-	0	217																											TACTGAAGGTGAATCCAGAGG	0.567000													19	91					0	0	0.007413	0	0
ALPK2	115701	broad.mit.edu	37	18	56246599	56246599	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:56246599C>T	ENST00000361673.3	-	4	1622	c.1409G>A	c.(1408-1410)aGa>aAa	p.R470K		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	470							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						GTGGCTGTCTCTGGTTTCTCC	0.473000											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	121					0	0	0.004656	0	0
NEB	4703	broad.mit.edu	37	2	152499762	152499762	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:152499762G>A	ENST00000427231.2	-	58	8264	c.8062C>T	c.(8062-8064)Cat>Tat	p.H2688Y	NEB_ENST00000604864.1_Missense_Mutation_p.H2688Y|NEB_ENST00000603639.1_Missense_Mutation_p.H2688Y|NEB_ENST00000172853.10_Missense_Mutation_p.H2688Y|NEB_ENST00000409198.1_Missense_Mutation_p.H2688Y|NEB_ENST00000397345.3_Missense_Mutation_p.H2688Y	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2688					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CGGTAAACATGGTCACTCAAA	0.418000													21	109					0	0	0.012319	0	0
FGFBP3	143282	broad.mit.edu	37	10	93668130	93668130	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:93668130G>A	ENST00000311575.5	-	2	760	c.597C>T	c.(595-597)ccC>ccT	p.P199P		NM_152429.4	NP_689642.3	Q8TAT2	FGFP3_HUMAN	fibroblast growth factor binding protein 3	199					positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of vascular permeability	extracellular region	fibroblast growth factor binding|heparin binding	p.P199P(1)		large_intestine(1)|prostate(1)	2		Colorectal(252;0.162)				TCCTCTCTGAGGGGTTTTCTT	0.731000													8	41					0	0	0.004482	0	0
CLGN	1047	broad.mit.edu	37	4	141317270	141317270	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:141317270G>A	ENST00000325617.5	-	9	1414	c.974C>T	c.(973-975)cCt>cTt	p.P325L	CLGN_ENST00000414773.1_Missense_Mutation_p.P325L|CLGN_ENST00000537281.1_Missense_Mutation_p.P325L	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	325					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					TTCAGCATTAGGATCAGGGAT	0.363000													15	113					0	0	0.003163	0	0
CSMD2	114784	broad.mit.edu	37	1	33998709	33998709	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:33998709G>A	ENST00000373381.4	-	64	10288	c.10112C>T	c.(10111-10113)tCc>tTc	p.S3371F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3227						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCGGTGCTCGGAGCCACCCTT	0.667000													6	24					0	0	0.001168	0	0
REXO1	57455	broad.mit.edu	37	19	1823627	1823627	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:1823627G>A	ENST00000170168.4	-	4	2268	c.2174C>T	c.(2173-2175)tCc>tTc	p.S725F	CTB-31O20.4_ENST00000593201.1_RNA|CTB-31O20.4_ENST00000587741.1_RNA	NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	725						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGGGGCGGAAATGTGGAC	0.716000													6	15					0	0	0.001984	0	0
CCDC147	159686	broad.mit.edu	37	10	106207461	106207461	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:106207461G>A	ENST00000369704.3	+	16	2396	c.2262G>A	c.(2260-2262)aaG>aaA	p.K754K		NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	754										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ACTAGGAAAAGGAGAAACTCT	0.542000													15	82					0	0	0.002450	0	0
TTC18	118491	broad.mit.edu	37	10	75104921	75104921	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:75104921C>T	ENST00000401621.2	-	6	631	c.511G>A	c.(511-513)Gtc>Atc	p.V171I	TTC18_ENST00000340329.3_Missense_Mutation_p.V171I|TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000394865.1_Missense_Mutation_p.V171I|TTC18_ENST00000310715.3_Missense_Mutation_p.V171I			Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	171							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					TCCAACGTGACCTTCAGTAGA	0.473000													21	79					0	0	0.008871	0	0
BMP15	9210	broad.mit.edu	37	X	50659565	50659565	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:50659565G>A	ENST00000252677.3	+	2	1137	c.1137G>A	c.(1135-1137)aaG>aaA	p.K379K		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	379					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					TTTTGTACAAGGAGTATGAGG	0.458000													9	30					0	0	0.008291	0	0
NF1	4763	broad.mit.edu	37	17	29653263	29653263	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:29653263C>T	ENST00000358273.4	+	37	5644	c.5261C>T	c.(5260-5262)tCt>tTt	p.S1754F	NF1_ENST00000356175.3_Missense_Mutation_p.S1733F|NF1_ENST00000581113.2_3'UTR	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1754					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ACCAAAGTTTCTATTAAAGTA	0.423000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			7	31					0	0	0.004482	0	0
DCDC1	341019	broad.mit.edu	37	11	30902782	30902782	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:30902782G>T	ENST00000597505.1	-	35	5146	c.5147C>A	c.(5146-5148)cCa>cAa	p.P1716Q				P59894	DCDC1_HUMAN	doublecortin domain containing 1	222					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GGACTGAATTGGCTCTCCACT	0.498000													6	56					0.00116845	0.00120599	0.001168	1	0
CACNG6	59285	broad.mit.edu	37	19	54501531	54501531	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:54501531G>A	ENST00000252729.2	+	2	960	c.370G>A	c.(370-372)Gag>Aag	p.E124K	CACNG6_ENST00000352529.1_Intron|CACNG6_ENST00000346968.2_Missense_Mutation_p.E124K	NM_145814.1	NP_665813.1	Q9BXT2	CCG6_HUMAN	calcium channel, voltage-dependent, gamma subunit 6	124						voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		CACCACGGGGGAGAATGCACG	0.512000													14	59					0	0	0.003163	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31120239	31120239	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:31120239G>A	ENST00000304166.4	+	5	566	c.277G>A	c.(277-279)Gaa>Aaa	p.E93K	ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.E93K|ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.E93K|ADCYAP1R1_ENST00000409363.1_Intron	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	93					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						CTGGGAGACCGAAACCATTGG	0.562000													12	56					0	0	0.002450	0	0
KCNN2	3781	broad.mit.edu	37	5	113699644	113699644	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:113699644C>T	ENST00000512097.3	+	3	1546	c.528C>T	c.(526-528)ctC>ctT	p.L176L	KCNN2_ENST00000264773.3_Silent_p.L176L|KCNN2_ENST00000507750.1_3'UTR			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	176						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TTATCAGTCTCTCCACGATCA	0.478000													16	86					0	0	0.010504	0	0
BPIFB2	80341	broad.mit.edu	37	20	31607447	31607447	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:31607447C>T	ENST00000170150.3	+	11	1166	c.971C>T	c.(970-972)cCt>cTt	p.P324L		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	324						extracellular region	lipid binding										GGTGCCACACCTGTGGCCATG	0.672000													16	38					0	0	0.004990	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86509800	86509800	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:86509800G>A	ENST00000450689.2	-	22	3262	c.3077C>T	c.(3076-3078)tCc>tTc	p.S1026F	KIAA1324L_ENST00000297222.6_Missense_Mutation_p.S786F|KIAA1324L_ENST00000444627.1_Missense_Mutation_p.S955F|KIAA1324L_ENST00000416314.1_Missense_Mutation_p.S859F	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	1026						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					TATATTTGGGGATCTTGAGGT	0.348000													11	48					0	0	0.010729	0	0
CLSTN1	22883	broad.mit.edu	37	1	9809659	9809659	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:9809659G>A	ENST00000377298.4	-	7	1637	c.845C>T	c.(844-846)gCc>gTc	p.A282V	CLSTN1_ENST00000361311.4_Missense_Mutation_p.A272V|CLSTN1_ENST00000377288.3_Missense_Mutation_p.A282V	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	282					homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		TGGAAAGACGGCCAACGCGCC	0.552000													9	70					0	0	0.004482	0	0
TUBD1	51174	broad.mit.edu	37	17	57955542	57955542	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:57955542G>A	ENST00000325752.3	-	5	968	c.691C>T	c.(691-693)Ctc>Ttc	p.L231F	TUBD1_ENST00000394239.3_Missense_Mutation_p.L231F|TUBD1_ENST00000346141.6_Intron|TUBD1_ENST00000376094.4_Missense_Mutation_p.L231F|TUBD1_ENST00000592426.1_Missense_Mutation_p.L231F|TUBD1_ENST00000340993.6_Missense_Mutation_p.L231F|TUBD1_ENST00000539018.1_Missense_Mutation_p.L15F	NM_016261.3	NP_057345.2	Q9UJT1	TBD_HUMAN	tubulin, delta 1	231					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			TGATGTGCGAGGACTTGATTG	0.423000													9	39					0	0	0.006214	0	0
MYH15	22989	broad.mit.edu	37	3	108178266	108178266	+	Nonsense_Mutation	SNP	T	T	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:108178266T>A	ENST00000273353.3	-	19	2079	c.2023A>T	c.(2023-2025)Aaa>Taa	p.K675*	MYH15_ENST00000495753.2_5'UTR	NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	675	Actin-binding (By similarity).|Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GCTGTTGATTTCAGATTAGTC	0.323000													10	42					0	0	0.010729	0	0
GSR	2936	broad.mit.edu	37	8	30538528	30538528	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:30538528C>T	ENST00000221130.5	-	12	1402	c.1312G>A	c.(1312-1314)Gaa>Aaa	p.E438K	GSR_ENST00000546342.1_Missense_Mutation_p.E409K|GSR_ENST00000537535.1_Missense_Mutation_p.E356K|GSR_ENST00000414019.1_Missense_Mutation_p.E395K|GSR_ENST00000541648.1_Missense_Mutation_p.E385K	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	438					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TTCACATTTTCTATTCCATAT	0.353000													13	68					0	0	0.013537	0	0
ITPR3	3710	broad.mit.edu	37	6	33636831	33636831	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:33636831G>A	ENST00000374316.5	+	19	3147	c.2087G>A	c.(2086-2088)tGg>tAg	p.W696*	ITPR3_ENST00000605930.1_Nonsense_Mutation_p.W696*			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	696					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						TGGCTCACGTGGACTGACAAG	0.587000													21	112					0	0	0.002780	0	0
MVB12B	89853	broad.mit.edu	37	9	129154425	129154425	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:129154425C>T	ENST00000361171.3	+	5	571	c.490C>T	c.(490-492)Cgg>Tgg	p.R164W	MVB12B_ENST00000436593.3_Missense_Mutation_p.R149W|MVB12B_ENST00000545391.1_Missense_Mutation_p.R164W|MVB12B_ENST00000535766.1_Missense_Mutation_p.R157W	NM_033446.2	NP_258257.1			multivesicular body subunit 12B																		TTGTGACATTCGGATCATGGG	0.488000													26	101					0	0	0.004656	0	0
FANCG	2189	broad.mit.edu	37	9	35079438	35079438	+	Splice_Site	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:35079438C>T	ENST00000378643.3	-	1	575	c.84_splice	c.e1+1	p.K28_splice		NM_004629.1	NP_004620.1	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	28					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|stomach(1)	28			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ACCGTGTTACCTTGGCCTGTC	0.612000			"""Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks					23	83					0	0	0.003330	0	0
XKR4	114786	broad.mit.edu	37	8	56436718	56436718	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:56436718C>T	ENST00000327381.5	+	3	1985	c.1885C>T	c.(1885-1887)Cct>Tct	p.P629S		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	629						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TTCCCCATCTCCTCCAAGGCT	0.453000													12	46					0	0	0.001855	0	0
PRSS37	136242	broad.mit.edu	37	7	141536960	141536960	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:141536960C>T	ENST00000350549.3	-	4	890	c.519G>A	c.(517-519)agG>agA	p.R173R	PRSS37_ENST00000438520.1_Silent_p.R173R	NM_001008270.2|NM_001171951.1	NP_001008271.2|NP_001165422.1	A4D1T9	PRS37_HUMAN	protease, serine, 37	173	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(3)	15						ATAAGGAATTCCTGTGGCTTT	0.453000													6	56					0	0	0.001168	0	0
OGDHL	55753	broad.mit.edu	37	10	50946248	50946248	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:50946248C>T	ENST00000374103.4	-	18	2465	c.2380G>A	c.(2380-2382)Gat>Aat	p.D794N	OGDHL_ENST00000490844.1_5'UTR|OGDHL_ENST00000419399.1_Missense_Mutation_p.D737N|OGDHL_ENST00000432695.1_Missense_Mutation_p.D585N	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	794					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						GGGTAGGCATCCGAGTCATCA	0.622000													11	70					0	0	0.010729	0	0
OR10H1	26539	broad.mit.edu	37	19	15918755	15918755	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:15918755G>A	ENST00000334920.2	-	1	181	c.93C>T	c.(91-93)ttC>ttT	p.F31F		NM_013940.2	NP_039228.1	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H, member 1	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|skin(2)|urinary_tract(1)	29						ACATCAGCAGGAACAGCAGGA	0.592000													19	81					0	0	0.002780	0	0
GABRB1	2560	broad.mit.edu	37	4	47427981	47427981	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:47427981C>T	ENST00000295454.3	+	9	1663	c.1371C>T	c.(1369-1371)ttC>ttT	p.F457F	GABRB1_ENST00000538619.1_Silent_p.F387F	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	457					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GAATGTTTTTCCCCATCACCT	0.458000													19	81					0	0	0.008871	0	0
C1orf173	127254	broad.mit.edu	37	1	75037778	75037778	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:75037778C>T	ENST00000326665.5	-	14	3834	c.3616G>A	c.(3616-3618)Gaa>Aaa	p.E1206K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1206	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CGGTGCCCTTCCTTCAGGGCC	0.592000													28	115					0	0	0.006320	0	0
OR7G3	390883	broad.mit.edu	37	19	9237276	9237276	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9237276C>T	ENST00000305444.2	-	1	350	c.351G>A	c.(349-351)atG>atA	p.M117I		NM_001001958.1	NP_001001958.1	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G, member 3	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						CATAGGCCATCATGACCAGAA	0.483000													25	79					0	0	0.004656	0	0
TENM4	26011	broad.mit.edu	37	11	78413133	78413133	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:78413133C>T	ENST00000278550.7	-	28	4987	c.4525G>A	c.(4525-4527)Gcc>Acc	p.A1509T		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		CCACTGGGGGCCCCAGCAACG	0.468000													6	14					0	0	0.001984	0	0
RASSF1	11186	broad.mit.edu	37	3	50368147	50368147	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:50368147G>A	ENST00000359365.4	-	6	994	c.888C>T	c.(886-888)ttC>ttT	p.F296F	RASSF1_ENST00000395126.3_Silent_p.F145F|RASSF1_ENST00000327761.3_Silent_p.F226F|RASSF1_ENST00000357043.2_Silent_p.F300F	NM_001206957.1|NM_007182.4|NM_170714.1	NP_001193886.1|NP_009113.3|NP_733832.1	Q9NS23	RASF1_HUMAN	Ras association (RalGDS/AF-6) domain family member 1	300	SARAH.				cell cycle arrest|negative regulation of cell cycle arrest|positive regulation of protein ubiquitination|protein stabilization|Ras protein signal transduction|response to DNA damage stimulus	microtubule|microtubule cytoskeleton|microtubule organizing center|nucleus|spindle pole	identical protein binding|protein binding|protein N-terminus binding|zinc ion binding			lung(2)|ovary(1)|skin(1)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000278)|OV - Ovarian serous cystadenocarcinoma(275;0.0015)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CAGGCATGCTGAAGGCGTCCC	0.572000													11	57					0	0	0.008291	0	0
SNAP91	9892	broad.mit.edu	37	6	84269917	84269917	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:84269917C>T	ENST00000428679.2	-	28	3130	c.2537G>A	c.(2536-2538)gGg>gAg	p.G846E	SNAP91_ENST00000439399.2_Missense_Mutation_p.G846E|SNAP91_ENST00000195649.6_Missense_Mutation_p.G841E|SNAP91_ENST00000437520.1_Missense_Mutation_p.G539E|SNAP91_ENST00000521743.1_Missense_Mutation_p.G846E|SNAP91_ENST00000520302.1_Missense_Mutation_p.G816E|SNAP91_ENST00000369694.2_Missense_Mutation_p.G846E|SNAP91_ENST00000521485.1_Missense_Mutation_p.G841E|SNAP91_ENST00000520213.1_Missense_Mutation_p.G539E			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	846	Pro-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		CATGCCTGTCCCAGCAGGAGG	0.547000													13	68					0	0	0.004007	0	0
STAB1	23166	broad.mit.edu	37	3	52541961	52541961	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:52541961G>A	ENST00000321725.6	+	20	2143	c.2067G>A	c.(2065-2067)aaG>aaA	p.K689K		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	689					cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TCTTCCCCAAGGAGTGTGTCT	0.577000													14	68					0	0	0.004990	0	0
IGHV4-28	28400	broad.mit.edu	37	14	106780818	106780818	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:106780818C>T	ENST00000390612.2	-	0	118																											GACAGGACCACTGTGAACAGA	0.607000													19	34					0	0	0.008871	0	0
ITGB3	3690	broad.mit.edu	37	17	45377887	45377887	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:45377887G>A	ENST00000559488.1	+	12	1973	c.1957G>A	c.(1957-1959)Gac>Aac	p.D653N	ITGB3_ENST00000560629.1_Silent_p.*641*|ITGB3_ENST00000435993.2_Missense_Mutation_p.D606N	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	653				GALHD -> EPYMT (in Ref. 1; AAA52589, 2; AAA60122 and 4; AAB71380).	activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	AGCCCTACATGACGAAAATAC	0.473000													6	31					0	0	0.008291	0	0
TLL2	7093	broad.mit.edu	37	10	98154973	98154973	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:98154973T>G	ENST00000357947.3	-	13	1922	c.1697A>C	c.(1696-1698)aAa>aCa	p.K566T	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	566	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		AAAGCCCGCTTTATTGATAGA	0.468000													27	130					0	0	0.009535	0	0
ZNF536	9745	broad.mit.edu	37	19	31039149	31039149	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:31039149G>A	ENST00000355537.3	+	4	2770	c.2623G>A	c.(2623-2625)Ggc>Agc	p.G875S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	875					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GCAGGCCACGGGCATGTCTTC	0.552000													19	80					0	0	0.008871	0	0
HSD17B3	3293	broad.mit.edu	37	9	99013729	99013729	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:99013729G>A	ENST00000375263.3	-	5	471	c.424C>T	c.(424-426)Cat>Tat	p.H142Y	HSD17B3_ENST00000375262.2_Missense_Mutation_p.H142Y	NM_000197.1	NP_000188.1	P37058	DHB3_HUMAN	hydroxysteroid (17-beta) dehydrogenase 3	142					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	TTCAGGAAATGGCTTGGGAGA	0.463000													11	49					0	0	0.008291	0	0
ZIC4	84107	broad.mit.edu	37	3	147113803	147113803	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:147113803C>A	ENST00000383075.3	-	3	1036	c.524G>T	c.(523-525)tGg>tTg	p.W175L	ZIC4_ENST00000425731.3_Missense_Mutation_p.W213L|ZIC4_ENST00000491672.1_Intron|ZIC4_ENST00000484399.1_Missense_Mutation_p.W175L|ZIC4_ENST00000525172.2_Missense_Mutation_p.W225L|ZIC4_ENST00000473123.1_Missense_Mutation_p.W175L	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	175						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						ACACTCCTCCCAGAAGCAAAT	0.577000													10	210					1.76689e-08	1.83439e-08	0.006214	1	0
TENM3	55714	broad.mit.edu	37	4	183675993	183675993	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:183675993G>A	ENST00000511685.1	+	22	4596	c.4473G>A	c.(4471-4473)ggG>ggA	p.G1491G	TENM3_ENST00000406950.2_Silent_p.G1491G|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		CAGATCTAGGGAATATCCGGA	0.468000													13	62					0	0	0.004007	0	0
H6PD	9563	broad.mit.edu	37	1	9324635	9324635	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:9324635G>T	ENST00000377403.2	+	5	2385	c.2083G>T	c.(2083-2085)Gcc>Tcc	p.A695S	H6PD_ENST00000602477.1_Missense_Mutation_p.A706S	NM_004285.3	NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	695	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	GGGCATGGGTGCCGACGGGCA	0.682000													17	72					6.94344e-10	7.23702e-10	0.006122	1	0
C6orf15	29113	broad.mit.edu	37	6	31079422	31079422	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:31079422G>A	ENST00000259870.3	-	2	717	c.714C>T	c.(712-714)atC>atT	p.I238I		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	238	Gly-rich.									endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						TGATACCCCAGATTCCCTCAG	0.567000													14	52					0	0	0.002450	0	0
RAD51B	5890	broad.mit.edu	37	14	68353891	68353891	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:68353891G>A	ENST00000487270.1	+	7	774	c.726G>A	c.(724-726)ttG>ttA	p.L242L	RAD51B_ENST00000390683.3_Silent_p.L242L|RAD51B_ENST00000487861.1_Silent_p.L242L|RAD51B_ENST00000471583.1_Silent_p.L242L|RAD51B_ENST00000488612.1_Silent_p.L242L|RAD51B_ENST00000469165.2_3'UTR	NM_133509.3	NP_598193.2	O15315	RA51B_HUMAN	RAD51 paralog B	242					blood coagulation|DNA repair|reciprocal meiotic recombination	nucleoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity		HMGA2/RAD51B(11)	breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11						CATCCTCCTTGAAGTATTTGG	0.358000								Direct reversal of damage					13	49					0	0	0.001855	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373762	86373762	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:86373762A>G	ENST00000604798.1	-	8	1946	c.742T>C	c.(742-744)Tac>Cac	p.Y248H	MGAT4C_ENST00000393205.2_Missense_Mutation_p.Y277H|MGAT4C_ENST00000548651.1_Missense_Mutation_p.Y248H|MGAT4C_ENST00000552808.2_Missense_Mutation_p.Y248H|MGAT4C_ENST00000552435.2_Intron|MGAT4C_ENST00000332156.1_Missense_Mutation_p.Y248H|MGAT4C_ENST00000549405.2_Missense_Mutation_p.Y248H			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	248					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding	p.Y248H(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						GTTACCCAGTAAGTTCCTTCT	0.348000													6	37					0	0	0.001168	0	0
EFTUD2	9343	broad.mit.edu	37	17	42941122	42941122	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:42941122G>A	ENST00000426333.2	-	15	1611	c.1314C>T	c.(1312-1314)atC>atT	p.I438I	EFTUD2_ENST00000592576.1_Silent_p.I428I|EFTUD2_ENST00000591382.1_Silent_p.I438I|EFTUD2_ENST00000402521.3_Silent_p.I403I	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	438						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				TTGGAGAAGGGATATGCTGCA	0.547000													20	91					0	0	0.003330	0	0
OR2M4	26245	broad.mit.edu	37	1	248402677	248402677	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:248402677G>A	ENST00000306687.1	+	1	447	c.447G>A	c.(445-447)tgG>tgA	p.W149*		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTGCTTCCTGGACCTTGGGGT	0.463000													15	80					0	0	0.003163	0	0
TMEM176B	28959	broad.mit.edu	37	7	150489193	150489193	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:150489193G>A	ENST00000447204.2	-	6	1043	c.671C>T	c.(670-672)tCc>tTc	p.S224F	TMEM176B_ENST00000492607.1_Missense_Mutation_p.S224F|TMEM176B_ENST00000434545.1_Missense_Mutation_p.S224F|TMEM176B_ENST00000326442.5_Missense_Mutation_p.S224F|TMEM176B_ENST00000429904.2_Missense_Mutation_p.S224F|TMEM176B_ENST00000450753.2_Missense_Mutation_p.S187F	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	224					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TACTCCCAAGGAAACCAAGGA	0.547000													15	49					0	0	0.004007	0	0
TTN	7273	broad.mit.edu	37	2	179439727	179439727	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:179439727A>G	ENST00000589042.1	-	326	71356	c.71132T>C	c.(71131-71133)aTt>aCt	p.I23711T	TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.I21143T|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.I14838T|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.I14646T|TTN_ENST00000591111.1_Missense_Mutation_p.I22070T|TTN_ENST00000359218.5_Missense_Mutation_p.I14771T|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22070	Fibronectin type-III 72.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTCCTACAATGTTCCTTGC	0.403000													3	36					0	0	0.004672	0	0
UBQLN3	50613	broad.mit.edu	37	11	5530615	5530615	+	Silent	SNP	G	G	A	rs139187349		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:5530615G>A	ENST00000311659.4	-	2	321	c.174C>T	c.(172-174)ccC>ccT	p.P58P	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	58	Ubiquitin-like.									NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAAGCTGATCGGGGTGGGCCT	0.507000													30	106					0	0	0.012213	0	0
NAV3	89795	broad.mit.edu	37	12	78598739	78598739	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:78598739G>A	ENST00000397909.2	+	39	7032	c.6859G>A	c.(6859-6861)Gaa>Aaa	p.E2287K	NAV3_ENST00000536525.2_Missense_Mutation_p.E2265K|NAV3_ENST00000266692.7_Missense_Mutation_p.E2088K|NAV3_ENST00000228327.6_Missense_Mutation_p.E2265K|NAV3_ENST00000541270.1_Missense_Mutation_p.E117K			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2287						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CACACCATGGGAAGATCCTTC	0.458000										HNSCC(70;0.22)			4	19					0	0	0.009096	0	0
DPYSL5	56896	broad.mit.edu	37	2	27164914	27164914	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:27164914C>T	ENST00000288699.6	+	10	1344	c.1186C>T	c.(1186-1188)Ccc>Tcc	p.P396S	DPYSL5_ENST00000401478.1_Missense_Mutation_p.P396S	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	396					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGCATTATTCCCGGAGCCGA	0.532000											OREG0014510	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	138					0	0	0.012213	0	0
STC1	6781	broad.mit.edu	37	8	23702445	23702445	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:23702445G>A	ENST00000290271.2	-	4	865	c.582C>T	c.(580-582)ttC>ttT	p.F194F	STC1_ENST00000524323.1_Silent_p.F125F	NM_003155.2	NP_003146.1	P52823	STC1_HUMAN	stanniocalcin 1	194					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GCAGGATGTGGAAGAGGCTGG	0.532000													14	74					0	0	0.003163	0	0
INPP4B	8821	broad.mit.edu	37	4	143235912	143235912	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:143235912G>A	ENST00000513000.1	-	9	809	c.376C>T	c.(376-378)Cga>Tga	p.R126*	INPP4B_ENST00000262992.4_Nonsense_Mutation_p.R126*|INPP4B_ENST00000308502.4_Nonsense_Mutation_p.R126*|INPP4B_ENST00000509777.1_Nonsense_Mutation_p.R126*|INPP4B_ENST00000508116.1_Nonsense_Mutation_p.R126*	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	126	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					ACACTGGTTCGAACCTGTGGA	0.448000													35	115					0	0	0.006999	0	0
ZBTB18	10472	broad.mit.edu	37	1	244217202	244217202	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:244217202C>T	ENST00000358704.4	+	2	275	c.126C>T	c.(124-126)gcC>gcT	p.A42A		NM_001278196.1|NM_006352.4|NM_205768.2	NP_001265125.1|NP_006343.2|NP_991331.1			zinc finger and BTB domain containing 18																		TGGGAGATGCCCAGTTCCGAG	0.488000													15	57					0	0	0.003163	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209190278	209190278	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:209190278C>T	ENST00000264380.4	+	20	2901	c.2743C>T	c.(2743-2745)Cct>Tct	p.P915S		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	915					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						CCCCTGGGATCCTGACATCCC	0.502000													5	44					0	0	0.000602	0	0
SH3GL2	6456	broad.mit.edu	37	9	17791333	17791333	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:17791333G>A	ENST00000380607.4	+	7	848		c.e7+1		SH3GL2_ENST00000537391.1_Splice_Site	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2						axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		TGGAAGAAAGGTATTCTACAG	0.428000													18	85					0	0	0.007413	0	0
SCN2A	6326	broad.mit.edu	37	2	166243504	166243504	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:166243504G>A	ENST00000357398.3	+	26	5090	c.4800G>A	c.(4798-4800)gtG>gtA	p.V1600V	SCN2A_ENST00000283256.6_Silent_p.V1600V|SCN2A_ENST00000375427.2_Silent_p.V1600V|SCN2A_ENST00000375437.2_Silent_p.V1600V			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1600					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TTGATTTTGTGGTGGTCATTC	0.333000													19	69					0	0	0.012319	0	0
TMEM117	84216	broad.mit.edu	37	12	44781975	44781975	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:44781975C>T	ENST00000266534.3	+	8	1192	c.1065C>T	c.(1063-1065)acC>acT	p.T355T	TMEM117_ENST00000546978.1_3'UTR|TMEM117_ENST00000536799.1_Silent_p.T251T|TMEM117_ENST00000551577.1_3'UTR	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	355						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TGAACAGAACCAAGCTATCCT	0.398000													13	51					0	0	0.013537	0	0
FAT4	79633	broad.mit.edu	37	4	126371171	126371171	+	Silent	SNP	G	G	A	rs142357260		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:126371171G>A	ENST00000394329.3	+	9	9013	c.9000G>A	c.(8998-9000)acG>acA	p.T3000T	FAT4_ENST00000335110.5_Silent_p.T1298T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3000	Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGGTTGGTACGAAGTTAATCA	0.318000													7	46					0	0	0.001984	0	0
ACACB	32	broad.mit.edu	37	12	109677704	109677704	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:109677704G>A	ENST00000338432.7	+	35	4851	c.4732G>A	c.(4732-4734)Gtg>Atg	p.V1578M	ACACB_ENST00000377848.3_Missense_Mutation_p.V1578M|ACACB_ENST00000543201.1_Missense_Mutation_p.V244M|ACACB_ENST00000377854.5_Missense_Mutation_p.V1508M			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1578					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CGAGCTGGAGGTGGCGTTCAA	0.592000													7	34					0	0	0.001984	0	0
CHRNA6	8973	broad.mit.edu	37	8	42611307	42611307	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:42611307G>A	ENST00000276410.2	-	5	1390	c.1035C>T	c.(1033-1035)ttC>ttT	p.F345F	CHRNA6_ENST00000534622.1_Silent_p.F330F	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	345						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GCAGCTTCAGGAAAACTGTCT	0.572000													11	62					0	0	0.013537	0	0
TPCN2	219931	broad.mit.edu	37	11	68855350	68855350	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:68855350C>T	ENST00000294309.3	+	25	2289	c.2188C>T	c.(2188-2190)Ctg>Ttg	p.L730L	TPCN2_ENST00000442692.2_3'UTR|TPCN2_ENST00000542467.1_Silent_p.L548L	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	730					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CAGGGATATTCTGGAGGAGCC	0.622000													5	30					0	0	0.000602	0	0
PRSS55	203074	broad.mit.edu	37	8	10390447	10390447	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:10390447G>A	ENST00000328655.3	+	4	670	c.630G>A	c.(628-630)atG>atA	p.M210I	PRSS55_ENST00000522210.1_Missense_Mutation_p.M210I|PRSS51_ENST00000523024.1_RNA	NM_198464.3	NP_940866.2	Q6UWB4	PRS55_HUMAN	protease, serine, 55	210	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)	31						CGGATCTGATGAAAGCGCCAA	0.478000													16	58					0	0	0.006122	0	0
FIBIN	387758	broad.mit.edu	37	11	27016142	27016142	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:27016142C>T	ENST00000318627.2	+	1	515	c.69C>T	c.(67-69)ccC>ccT	p.P23P		NM_203371.1	NP_976249.1	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog (zebrafish)	23						extracellular region|Golgi apparatus				breast(1)|endometrium(2)|lung(7)|upper_aerodigestive_tract(1)	11						TCGATGGCCCCCTCTACCCAG	0.542000													8	58					0	0	0.008291	0	0
IL1B	3553	broad.mit.edu	37	2	113588878	113588878	+	Silent	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:113588878T>C	ENST00000263341.2	-	6	798	c.588A>G	c.(586-588)ctA>ctG	p.L196L	IL1B_ENST00000491056.1_5'UTR	NM_000576.2	NP_000567.1	P01584	IL1B_HUMAN	interleukin 1, beta	196					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			breast(2)|central_nervous_system(1)|large_intestine(1)|lung(8)	12					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	CCTCCAGCTGTAGAGTGGGCT	0.493000													40	175					0	0	0.011902	0	0
FSIP2	401024	broad.mit.edu	37	2	186697897	186697897	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:186697897C>T	ENST00000343098.5	+	23	20935	c.20935C>T	c.(20935-20937)Caa>Taa	p.Q6979*	FSIP2_ENST00000424728.1_Nonsense_Mutation_p.Q6890*	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						GGTGTTTTCTCAATGTAACAC	0.378000													4	31					0	0	0.000602	0	0
DGCR2	9993	broad.mit.edu	37	22	19055628	19055628	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:19055628G>A	ENST00000545799.1	-	3	513	c.313C>T	c.(313-315)Ccc>Tcc	p.P105S	DGCR2_ENST00000263196.7_Missense_Mutation_p.P105S|DGCR2_ENST00000537045.1_Missense_Mutation_p.P64S			P98153	IDD_HUMAN	DiGeorge syndrome critical region gene 2	105					cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)	18	Colorectal(54;0.0993)					AAGCGAACGGGCTGCGCCACG	0.642000													8	35					0	0	0.006214	0	0
ATP4A	495	broad.mit.edu	37	19	36054383	36054383	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:36054383C>T	ENST00000262623.3	-	2	87	c.59G>A	c.(58-60)gGg>gAg	p.G20E		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	20					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	AGCCATGTCCCCGCCAGGGCC	0.577000													45	156					0	0	0.011902	0	0
FAT3	120114	broad.mit.edu	37	11	92086457	92086457	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:92086457C>T	ENST00000298047.6	+	1	1196	c.1179C>T	c.(1177-1179)gtC>gtT	p.V393V	FAT3_ENST00000409404.2_Silent_p.V393V|FAT3_ENST00000525166.1_Silent_p.V243V|FAT3_ENST00000541502.1_Silent_p.V393V			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	393	Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.V393V(2)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTCCTGGTGTCGTGGTTGCTA	0.423000										TCGA Ovarian(4;0.039)			94	450					0	0	0.014410	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6311567	6311567	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:6311567G>A	ENST00000400104.3	-	3	258	c.58C>T	c.(58-60)Cag>Tag	p.Q20*	L3MBTL4_ENST00000317931.7_Nonsense_Mutation_p.Q20*|L3MBTL4_ENST00000284898.6_Nonsense_Mutation_p.Q20*|L3MBTL4_ENST00000400105.2_Nonsense_Mutation_p.Q20*			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	20					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				CGTCCGTCCTGATCCAAACGC	0.483000													51	236					0	0	0.014410	0	0
NRK	203447	broad.mit.edu	37	X	105179208	105179208	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:105179208C>T	ENST00000428173.2	+	21	3852	c.3549C>T	c.(3547-3549)ccC>ccT	p.P1183P	NRK_ENST00000243300.9_Silent_p.P1182P			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1182							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						CTAAGCAACCCTCTGAAGTCA	0.408000										HNSCC(51;0.14)			23	59					0	0	0.002780	0	0
KCNQ3	3786	broad.mit.edu	37	8	133175718	133175718	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:133175718G>A	ENST00000388996.4	-	9	1679	c.1259C>T	c.(1258-1260)tCc>tTc	p.S420F	KCNQ3_ENST00000521134.1_Missense_Mutation_p.S300F|KCNQ3_ENST00000519445.1_Missense_Mutation_p.S420F	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	420					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			AACTTACCTGGATGCTGCCTC	0.453000													7	50					0	0	0.003080	0	0
IGFN1	91156	broad.mit.edu	37	1	201182705	201182705	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:201182705C>T	ENST00000335211.4	+	12	8814	c.8684C>T	c.(8683-8685)tCc>tTc	p.S2895F	IGFN1_ENST00000451870.2_Missense_Mutation_p.S438F|IGFN1_ENST00000295591.8_Missense_Mutation_p.S55F	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						AGTTCCACATCCAGATACAAG	0.587000													8	54					0	0	0.004482	0	0
RERG	85004	broad.mit.edu	37	12	15262170	15262170	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:15262170C>T	ENST00000256953.2	-	5	810	c.474G>A	c.(472-474)gaG>gaA	p.E158E	RERG_ENST00000546331.1_Silent_p.E139E|RERG_ENST00000536465.1_Silent_p.E158E|RERG_ENST00000538313.1_Silent_p.E158E	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	158					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						CATAGAATATCTCTGTGATGT	0.537000													24	71					0	0	0.003330	0	0
IGDCC4	57722	broad.mit.edu	37	15	65676747	65676747	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:65676747C>T	ENST00000352385.2	-	20	3562	c.3353G>A	c.(3352-3354)aGg>aAg	p.R1118K	IGDCC4_ENST00000558048.1_5'UTR	NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1118						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						TGACTTCTTCCTCCCATTGCC	0.512000													23	133					0	0	0.002780	0	0
SHMT2	6472	broad.mit.edu	37	12	57628077	57628077	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:57628077C>T	ENST00000328923.3	+	12	1900	c.1448C>T	c.(1447-1449)gCc>gTc	p.A483V	SHMT2_ENST00000449049.3_Missense_Mutation_p.A462V|SHMT2_ENST00000414700.3_Missense_Mutation_p.A462V|SHMT2_ENST00000393827.4_Missense_Mutation_p.A387V|SHMT2_ENST00000557487.1_Missense_Mutation_p.A473V|SHMT2_ENST00000553474.1_Missense_Mutation_p.A462V	NM_001166356.1|NM_005412.5	NP_001159828.1|NP_005403.2	P34897	GLYM_HUMAN	serine hydroxymethyltransferase 2 (mitochondrial)	483						microtubule cytoskeleton|mitochondrial nucleoid	glycine hydroxymethyltransferase activity|methyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15					Glycine(DB00145)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CAGCGTCTGGCCAACCTCAGG	0.527000													17	105					0	0	0.006122	0	0
RPLP0P2	113157	broad.mit.edu	37	11	61404369	61404369	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:61404369C>T	ENST00000496593.1	+	0	973					NR_002775.2																						GAAAACAGCCCAGCTCTGGAG	0.592000													6	18					0	0	0.004482	0	0
ANO4	121601	broad.mit.edu	37	12	101493391	101493391	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:101493391G>A	ENST00000392979.3	+	21	2298	c.1937G>A	c.(1936-1938)cGa>cAa	p.R646Q	ANO4_ENST00000392977.3_Missense_Mutation_p.R681Q|ANO4_ENST00000550015.1_Missense_Mutation_p.R201Q|ANO4_ENST00000299222.9_Missense_Mutation_p.R201Q	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	681						chloride channel complex	chloride channel activity	p.R646Q(2)		NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						AGAAAAGTACGACAAGAACAT	0.353000										HNSCC(74;0.22)			9	47					0	0	0.008291	0	0
SLC16A7	9194	broad.mit.edu	37	12	60168885	60168885	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:60168885C>T	ENST00000261187.4	+	4	973	c.809C>T	c.(808-810)cCa>cTa	p.P270L	SLC16A7_ENST00000547379.1_Missense_Mutation_p.P270L|SLC16A7_ENST00000552024.1_Missense_Mutation_p.P270L|SLC16A7_ENST00000543448.1_Missense_Mutation_p.P171L|SLC16A7_ENST00000552432.1_Missense_Mutation_p.P270L	NM_001270622.1|NM_001270623.1|NM_004731.3	NP_001257551.1|NP_001257552.1|NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	270						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	TTCTTGGCTCCATATGCTAAA	0.373000													12	45					0	0	0.010729	0	0
CSMD1	64478	broad.mit.edu	37	8	3205627	3205627	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:3205627G>A	ENST00000520002.1	-	23	3919	c.3364C>T	c.(3364-3366)Cca>Tca	p.P1122S	CSMD1_ENST00000602723.1_Missense_Mutation_p.P1122S|CSMD1_ENST00000400186.3_Missense_Mutation_p.P1122S|CSMD1_ENST00000602557.1_Missense_Mutation_p.P1122S|CSMD1_ENST00000542608.1_Missense_Mutation_p.P1121S|CSMD1_ENST00000539096.1_Missense_Mutation_p.P1121S|CSMD1_ENST00000537824.1_Missense_Mutation_p.P1121S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1122	CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TAATTGGATGGAAAATTTGGA	0.393000													7	23					0	0	0.003080	0	0
BTBD11	121551	broad.mit.edu	37	12	108029142	108029142	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:108029142C>T	ENST00000280758.5	+	12	3240	c.2712C>T	c.(2710-2712)atC>atT	p.I904I	BTBD11_ENST00000494235.2_5'UTR|BTBD11_ENST00000357167.4_Silent_p.I441I|BTBD11_ENST00000420571.2_Silent_p.I785I|BTBD11_ENST00000490090.2_Silent_p.I904I	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	904						integral to membrane	DNA binding	p.I904I(1)		NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TCACAGAAATCAAACGGAAAC	0.532000													11	80					0	0	0.008291	0	0
OR6B1	135946	broad.mit.edu	37	7	143701780	143701780	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:143701780G>A	ENST00000408922.2	+	1	759	c.691G>A	c.(691-693)Gga>Aga	p.G231R		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					CATGCCCACAGGAAAGCAGAA	0.463000													53	142					0	0	0.014410	0	0
RGS11	8786	broad.mit.edu	37	16	321083	321083	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:321083C>T	ENST00000397770.3	-	13	896	c.879G>A	c.(877-879)acG>acA	p.T293T	ARHGDIG_ENST00000464609.1_Intron|RGS11_ENST00000359740.5_Silent_p.T282T|RGS11_ENST00000316163.5_Silent_p.T272T			O94810	RGS11_HUMAN	regulator of G-protein signaling 11	293					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(1)|kidney(1)|lung(4)|ovary(1)|pancreas(1)	8		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CACGGAGCTTCGTGGGGGCAG	0.682000													4	33					0	0	0.009096	0	0
RGPD3	653489	broad.mit.edu	37	2	107041038	107041038	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:107041038C>T	ENST00000409886.3	-	20	3472	c.3385G>A	c.(3385-3387)Gca>Aca	p.A1129T	RGPD3_ENST00000304514.7_Missense_Mutation_p.A1129T	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1129	RanBD1 1.				intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						CACATCCATGCTCTATCTGAT	0.428000													39	164					0	0	0.008740	0	0
C1orf106	55765	broad.mit.edu	37	1	200868692	200868692	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:200868692G>A	ENST00000367342.4	+	3	602	c.402G>A	c.(400-402)ctG>ctA	p.L134L	C1orf106_ENST00000413687.2_Silent_p.L49L	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	134										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						AGGCCTGCCTGGAGGAGCTGA	0.652000													7	18					0	0	0.001984	0	0
SLA2	84174	broad.mit.edu	37	20	35269686	35269686	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:35269686G>A	ENST00000262866.4	-	2	475	c.53C>T	c.(52-54)tCc>tTc	p.S18F	SLA2_ENST00000360672.2_Missense_Mutation_p.S18F	NM_032214.3|NM_175077.2	NP_115590.1|NP_778252.1	Q9H6Q3	SLAP2_HUMAN	Src-like-adaptor 2	18					antigen receptor-mediated signaling pathway|B cell mediated immunity|intracellular receptor mediated signaling pathway|negative regulation of B cell activation|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|T cell activation	cytoplasmic membrane-bounded vesicle|endosome membrane|plasma membrane	protein N-terminus binding|SH3/SH2 adaptor activity			endometrium(1)|lung(2)|skin(2)	5	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				TTGGACAGAGGAACTCAAGCT	0.542000													10	99					0	0	0.008291	0	0
GCKR	2646	broad.mit.edu	37	2	27726447	27726447	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:27726447G>A	ENST00000264717.2	+	9	774	c.711G>A	c.(709-711)caG>caA	p.Q237Q	GCKR_ENST00000424318.2_Silent_p.Q47Q	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	237	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					AGAAAATGCAGGAGAAACAGA	0.507000													5	27					0	0	0.000602	0	0
NLRP4	147945	broad.mit.edu	37	19	56369627	56369627	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:56369627C>T	ENST00000301295.6	+	3	1290	c.868C>T	c.(868-870)Cag>Tag	p.Q290*	NLRP4_ENST00000587891.1_Nonsense_Mutation_p.Q215*|NLRP4_ENST00000346986.5_Nonsense_Mutation_p.Q290*	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	290	NACHT.						ATP binding	p.Q290*(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GCTCCGGGATCAGGTGACGAT	0.537000													20	75					0	0	0.010504	0	0
INMT-FAM188B	100526825	broad.mit.edu	37	7	30791901	30791901	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:30791901C>T	ENST00000458257.1	+	1	149	c.135C>T	c.(133-135)ctC>ctT	p.L45L	INMT_ENST00000013222.5_Silent_p.L45L|INMT_ENST00000484180.1_Intron|INMT_ENST00000409539.1_Silent_p.L45L																							TGGAATGTCTCCACAAGACCT	0.592000													12	71					0	0	0.010729	0	0
IFNA21	3452	broad.mit.edu	37	9	21166419	21166419	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:21166419C>T	ENST00000380225.1	-	1	240	c.193G>A	c.(193-195)Gag>Aag	p.E65K		NM_002175.2	NP_002166.2	P01568	IFN21_HUMAN	interferon, alpha 21	65					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)	14				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CCATCAAACTCCTCCTGGGGG	0.507000													30	122					0	0	0.010818	0	0
ATP11A	23250	broad.mit.edu	37	13	113439572	113439572	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:113439572G>A	ENST00000487903.1	+	2	250		c.e2+1		ATP11A_ENST00000375630.2_Splice_Site|ATP11A_ENST00000375645.3_Splice_Site|ATP11A_ENST00000283558.8_Splice_Site			P98196	AT11A_HUMAN	ATPase, class VI, type 11A						ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CTCGTCCAAGGTAACTTGGCT	0.577000													33	65					0	0	0.004289	0	0
MUC16	94025	broad.mit.edu	37	19	9084051	9084051	+	Silent	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9084051T>C	ENST00000397910.4	-	1	7967	c.7764A>G	c.(7762-7764)gaA>gaG	p.E2588E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2588	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGCTGAAGTTTCCCAGTTTG	0.458000													19	87					0	0	0.010504	0	0
SLC30A3	7781	broad.mit.edu	37	2	27481130	27481130	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:27481130T>A	ENST00000233535.4	-	3	675	c.323A>T	c.(322-324)cAc>cTc	p.H108L	SLC30A3_ENST00000447008.2_Missense_Mutation_p.H103L	NM_003459.4	NP_003450.2	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter), member 3	108					regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|pancreas(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGCCAGCAAGTGGGCTGCATC	0.577000													10	36					0	0	0.013537	0	0
ATG5	9474	broad.mit.edu	37	6	106696042	106696042	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:106696042G>A	ENST00000369076.3	-	6	879	c.556C>T	c.(556-558)Ccc>Tcc	p.P186S	ATG5_ENST00000369070.1_Missense_Mutation_p.P108S|ATG5_ENST00000343245.3_Missense_Mutation_p.P186S|ATG5_ENST00000360666.4_Silent_p.S62S	NM_004849.2	NP_004840.1	Q9H1Y0	ATG5_HUMAN	autophagy related 5	186					apoptosis|autophagic vacuole assembly|negative regulation of type I interferon production|post-translational protein modification	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			endometrium(1)|large_intestine(5)|lung(1)|prostate(1)	8	Breast(9;0.0296)	all_cancers(87;0.000301)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0612)|Lung NSC(302;0.216)	BRCA - Breast invasive adenocarcinoma(8;0.00802)	OV - Ovarian serous cystadenocarcinoma(136;0.128)|Epithelial(106;0.159)|all cancers(137;0.18)		ATTCTAAAGGGGATATAACGA	0.328000													4	49					0	0	0.009096	0	0
FCN3	8547	broad.mit.edu	37	1	27697178	27697178	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:27697178G>A	ENST00000270879.4	-	7	572	c.567C>T	c.(565-567)aaC>aaT	p.N189N	FCN3_ENST00000354982.2_Silent_p.N178N	NM_003665.2	NP_003656.2	O75636	FCN3_HUMAN	ficolin (collagen/fibrinogen domain containing) 3	189	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	7		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGAAAGTACGGTTACCATTAA	0.582000													26	135					0	0	0.006320	0	0
HYDIN	54768	broad.mit.edu	37	16	71212830	71212830	+	Splice_Site	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:71212830C>T	ENST00000393567.2	-	4	532		c.e4+1		HYDIN_ENST00000541601.1_Splice_Site|HYDIN_ENST00000448691.1_Splice_Site|HYDIN_ENST00000538248.1_Splice_Site|HYDIN_ENST00000393550.2_Splice_Site|HYDIN_ENST00000321489.5_Splice_Site|HYDIN_ENST00000448089.2_Splice_Site|HYDIN_ENST00000288168.10_Splice_Site	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein											breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AACATACTCACTTTGTCATTG	0.378000													26	92					0	0	0.010818	0	0
USP15	9958	broad.mit.edu	37	12	62790089	62790089	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:62790089C>T	ENST00000280377.5	+	20	2643	c.2585C>T	c.(2584-2586)tCg>tTg	p.S862L	USP15_ENST00000353364.3_Missense_Mutation_p.S833L|USP15_ENST00000393654.3_Missense_Mutation_p.S837L	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	862					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.S833L(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TTGGATATGTCGGAATTCTTA	0.378000													6	31					0	0	0.003080	0	0
A2ML1	144568	broad.mit.edu	37	12	8998064	8998064	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:8998064G>A	ENST00000299698.7	+	13	1683	c.1503G>A	c.(1501-1503)atG>atA	p.M501I	A2ML1_ENST00000539547.1_Missense_Mutation_p.M10I|A2ML1_ENST00000540049.1_3'UTR	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	345						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						GTTTGGTGATGGAGGGGCAGA	0.393000													8	35					0	0	0.006214	0	0
DKK2	27123	broad.mit.edu	37	4	107845316	107845316	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:107845316C>T	ENST00000285311.3	-	4	1280	c.575G>A	c.(574-576)gGg>gAg	p.G192E	DKK2_ENST00000510463.1_Missense_Mutation_p.G146E|DKK2_ENST00000513208.1_Missense_Mutation_p.G92E	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	192	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		ACAGCAAAACCCTTCAATGCA	0.473000													11	56					0	0	0.008291	0	0
EFCAB13	124989	broad.mit.edu	37	17	45456594	45456594	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:45456594G>A	ENST00000331493.2	+	14	1968	c.1557G>A	c.(1555-1557)aaG>aaA	p.K519K	EFCAB13_ENST00000517484.1_Silent_p.K423K	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		CTCTCGCCAAGGAGCGAAGTT	0.358000													6	44					0	0	0.003080	0	0
HCN1	348980	broad.mit.edu	37	5	45262128	45262128	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:45262128G>A	ENST00000303230.4	-	8	2625	c.2568C>T	c.(2566-2568)gtC>gtT	p.V856V		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	856						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GTGCTGGAGGGACTCCTCGGT	0.602000													21	97					0	0	0.004656	0	0
IGF2R	3482	broad.mit.edu	37	6	160496916	160496916	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:160496916C>T	ENST00000356956.1	+	36	5352	c.5204C>T	c.(5203-5205)cCa>cTa	p.P1735L		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1735					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ATACTCAATCCAATAGCAAAT	0.428000													17	76					0	0	0.004990	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862823	10862823	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr21:10862823C>T	ENST00000559480.1	+	0	119																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GTGAAGGTCTCCTGCAAGGCT	0.572000													10	135					0	0	0.008291	0	0
ZNF385D	79750	broad.mit.edu	37	3	21462796	21462796	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:21462796G>A	ENST00000281523.2	-	8	1616	c.1098C>T	c.(1096-1098)ttC>ttT	p.F366F		NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	366						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						CGGAAGTCTGGAACAGTGTTG	0.567000													6	14					0	0	0.001984	0	0
JMJD6	23210	broad.mit.edu	37	17	74714855	74714855	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:74714855A>C	ENST00000445478.2	-	6	1371	c.1168T>G	c.(1168-1170)Tcc>Gcc	p.S390A	JMJD6_ENST00000585429.1_Silent_p.P343P|JMJD6_ENST00000397625.4_Missense_Mutation_p.S390A	NM_001081461.1	NP_001074930.1	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6	390					mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			endometrium(2)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|skin(2)	16						TCGTCCTGGGAGGTGGTGTCC	0.627000													4	63					0	0	0.000602	0	0
BCAN	63827	broad.mit.edu	37	1	156622499	156622499	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:156622499G>A	ENST00000329117.4	+	8	2093	c.1757G>A	c.(1756-1758)gGa>gAa	p.G586E	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000361588.5_Missense_Mutation_p.G586E	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	586					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GAGGAGACAGGAAGCTCCGAG	0.622000													17	59					0	0	0.006122	0	0
UBXN7	26043	broad.mit.edu	37	3	196083650	196083650	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:196083650G>A	ENST00000296328.4	-	11	1450	c.1376C>T	c.(1375-1377)cCt>cTt	p.P459L	UBXN7_ENST00000535858.1_Missense_Mutation_p.P311L|UBXN7_ENST00000428095.1_Missense_Mutation_p.P297L	NM_015562.1	NP_056377.1	O94888	UBXN7_HUMAN	UBX domain protein 7	459	UBX.						protein binding			NS(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						TTTCCTTCGAGGAAAGTTGGT	0.393000													9	32					0	0	0.004482	0	0
CLVS1	157807	broad.mit.edu	37	8	62289219	62289219	+	Missense_Mutation	SNP	G	G	A	rs143211270	by1000genomes	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:62289219G>A	ENST00000519846.1	+	4	983	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	CLVS1_ENST00000518592.1_5'UTR|CLVS1_ENST00000325897.4_Missense_Mutation_p.E171K			Q8IUQ0	CLVS1_HUMAN	clavesin 1	171	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity	p.E171K(1)		endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						AGTCCTAATCGAAGATCCGGA	0.438000													7	71					0	0	0.003080	0	0
IQUB	154865	broad.mit.edu	37	7	123150072	123150072	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:123150072G>A	ENST00000466202.1	-	3	991	c.415C>T	c.(415-417)Cca>Tca	p.P139S	IQUB_ENST00000324698.6_Missense_Mutation_p.P139S|IQUB_ENST00000434450.1_Missense_Mutation_p.P139S|IQUB_ENST00000488987.1_Intron			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	139	Ubiquitin-like.									breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						TGGCCCACTGGAATAAGTACA	0.313000													16	147					0	0	0.004990	0	0
SDAD1	55153	broad.mit.edu	37	4	76879014	76879014	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:76879014C>T	ENST00000356260.5	-	18	1682	c.1564G>A	c.(1564-1566)Gaa>Aaa	p.E522K	SDAD1_ENST00000395711.4_Missense_Mutation_p.E485K	NM_018115.2	NP_060585.2	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	522					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	19			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCTTGCTGTTCTTCATCGGAA	0.408000													49	204					0	0	0.014410	0	0
GON4L	54856	broad.mit.edu	37	1	155753808	155753808	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:155753808G>A	ENST00000437809.1	-	14	1983	c.1861C>T	c.(1861-1863)Cgt>Tgt	p.R621C	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000368331.1_Missense_Mutation_p.R621C|GON4L_ENST00000361040.5_Missense_Mutation_p.R621C|GON4L_ENST00000271883.5_Missense_Mutation_p.R621C			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	621					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					AAGTTAGGACGAGGCTCAGCT	0.453000													26	68					0	0	0.010818	0	0
INHBB	3625	broad.mit.edu	37	2	121106868	121106868	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:121106868G>A	ENST00000295228.3	+	2	688	c.642G>A	c.(640-642)atG>atA	p.M214I		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	214					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				GGTGGAACATGGTGGAGAAGA	0.632000													23	109					0	0	0.003954	0	0
LRRC7	57554	broad.mit.edu	37	1	70555461	70555461	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:70555461G>A	ENST00000310961.5	+	25	4682	c.4264G>A	c.(4264-4266)Gga>Aga	p.G1422R	LRRC7_ENST00000035383.5_Missense_Mutation_p.G1464R|LRRC7_ENST00000415775.2_Missense_Mutation_p.G748R			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1464						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TATCAGTGGTGGAATTAGTGG	0.303000													10	41					0	0	0.002450	0	0
TAOK1	57551	broad.mit.edu	37	17	27835062	27835062	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:27835062T>C	ENST00000261716.3	+	14	2006	c.1487T>C	c.(1486-1488)tTa>tCa	p.L496S	TAOK1_ENST00000536202.1_Missense_Mutation_p.L496S	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	496					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			CGCCTCAGATTAGACAAAGAT	0.423000													6	17					0	0	0.001984	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51918821	51918821	+	Splice_Site	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:51918821C>T	ENST00000353836.5	-	6	1294		c.e6+1		SIGLEC10_ENST00000356298.5_Splice_Site|SIGLEC10_ENST00000339313.5_Splice_Site|SIGLEC10_ENST00000432469.2_Splice_Site|SIGLEC10_ENST00000436984.2_Splice_Site|SIGLEC10_ENST00000441969.3_Splice_Site|SIGLEC10_ENST00000442846.3_Splice_Site|SIGLEC10_ENST00000439889.2_Splice_Site|SIGLEC10_ENST00000525998.1_Splice_Site	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10						cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CCCTTTCCTACCTGTCCTGTT	0.617000													30	127					0	0	0.013726	0	0
TENM4	26011	broad.mit.edu	37	11	78437253	78437253	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:78437253C>T	ENST00000278550.7	-	23	3883	c.3421G>A	c.(3421-3423)Gaa>Aaa	p.E1141K		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		GATTCATATTCATAACCCACG	0.483000													34	158					0	0	0.004878	0	0
PKD1L1	168507	broad.mit.edu	37	7	47832359	47832359	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:47832359C>T	ENST00000289672.2	-	56	8442	c.8392G>A	c.(8392-8394)Gaa>Aaa	p.E2798K		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2798					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						ATCAGAAGTTCGTCTAACAGA	0.403000													10	36					0	0	0.010729	0	0
TTLL4	9654	broad.mit.edu	37	2	219617597	219617597	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:219617597C>A	ENST00000392102.1	+	17	3428	c.3088C>A	c.(3088-3090)Cat>Aat	p.H1030N	TTLL4_ENST00000442769.1_Missense_Mutation_p.H966N|TTLL4_ENST00000258398.4_Missense_Mutation_p.H1030N|TTLL4_ENST00000457313.1_Missense_Mutation_p.H865N	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	1030					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		TTTTCCTTCTCATATCTCCTC	0.448000													26	107					4.7796e-09	4.96704e-09	0.004656	1	0
CFB	629	broad.mit.edu	37	6	31895861	31895861	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:31895861C>T	ENST00000456570.1	+	2	231	c.176C>T	c.(175-177)cCa>cTa	p.P59L	C2_ENST00000442278.2_Intron|C2_ENST00000299367.5_Missense_Mutation_p.P59L|C2_ENST00000469372.1_Intron|C2_ENST00000418949.2_Missense_Mutation_p.P59L|C2_ENST00000452323.2_Intron|CFB_ENST00000556679.1_Missense_Mutation_p.P59L|CFB_ENST00000477310.1_Missense_Mutation_p.P59L			P00751	CFAB_HUMAN	complement factor B	70	Sushi 1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TACCCATCCCCAGCATCACGG	0.632000													33	330					0	0	0.003271	0	0
USP2	9099	broad.mit.edu	37	11	119243981	119243981	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:119243981G>A	ENST00000260187.2	-	2	504	c.210C>T	c.(208-210)tcC>tcT	p.S70S	USP2_ENST00000455332.2_Intron|RP11-334E6.3_ENST00000530918.2_RNA	NM_004205.4	NP_004196.4	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2	70	Necessary for interaction with MDM4.				cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	24		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		AGTCCAGGAGGGAGGAGGGGC	0.637000													21	115					0	0	0.014323	0	0
DTX4	23220	broad.mit.edu	37	11	58962779	58962779	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:58962779C>T	ENST00000227451.3	+	7	1577	c.1473C>T	c.(1471-1473)tcC>tcT	p.S491S	DTX4_ENST00000532982.1_Silent_p.S385S	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	491					Notch signaling pathway	cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				TCCCCCACTCCTTGCCTGGCC	0.562000													16	34					0	0	0.004990	0	0
SLC9A4	389015	broad.mit.edu	37	2	103128671	103128671	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:103128671C>T	ENST00000295269.4	+	7	1955	c.1498C>T	c.(1498-1500)Cac>Tac	p.H500Y		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	500					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						GCTGATGGATCACTTAAAGGC	0.443000													20	118					0	0	0.014323	0	0
RETSAT	54884	broad.mit.edu	37	2	85581623	85581623	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:85581623A>T	ENST00000295802.4	-	1	120	c.8T>A	c.(7-9)cTt>cAt	p.L3H	RETSAT_ENST00000457495.2_Missense_Mutation_p.L3H|RETSAT_ENST00000263854.6_Missense_Mutation_p.L3H	NM_017750.3	NP_060220.3	Q6NUM9	RETST_HUMAN	retinol saturase (all-trans-retinol 13,14-reductase)	3					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	30					Vitamin A(DB00162)	CACCAGCGGAAGCCACATCAC	0.612000													26	95					0	0	0.005443	0	0
ZNF831	128611	broad.mit.edu	37	20	57828183	57828183	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:57828183G>A	ENST00000371030.2	+	4	4178	c.4178G>A	c.(4177-4179)cGa>cAa	p.R1393Q		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1393						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					ATGGACAAACGAACTGTGAAG	0.468000													20	121					0	0	0.002780	0	0
HSF5	124535	broad.mit.edu	37	17	56540236	56540236	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:56540236T>G	ENST00000323777.3	-	4	1558	c.1449A>C	c.(1447-1449)caA>caC	p.Q483H		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	483						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGACATGAGCTTGCTGGATGG	0.473000													35	125					0	0	0.004878	0	0
ABCB5	340273	broad.mit.edu	37	7	20762706	20762706	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:20762706C>T	ENST00000404938.2	+	21	3141	c.2489C>T	c.(2488-2490)tCc>tTc	p.S830F	ABCB5_ENST00000258738.6_Missense_Mutation_p.S385F	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	385					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						GTTATCATTTCCTTTATATAT	0.413000													21	58					0	0	0.012319	0	0
POTEE	445582	broad.mit.edu	37	2	132021752	132021752	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:132021752C>T	ENST00000356920.5	+	15	2818	c.2724C>T	c.(2722-2724)atC>atT	p.I908I	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	908	Actin-like.						ATP binding										AGCGGGAAATCGTGCGTGACA	0.602000													15	128					0	0	0.014323	0	0
MUC13	56667	broad.mit.edu	37	3	124642407	124642407	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:124642407C>T	ENST00000311075.3	-	3	639	c.601G>A	c.(601-603)Ggg>Agg	p.G201R		NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	201	EGF-like 1.					extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						TAGTAATACCCTTCTAAACAC	0.418000													8	57					0	0	0.003080	0	0
YTHDF1	54915	broad.mit.edu	37	20	61834905	61834905	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:61834905G>A	ENST00000370339.3	-	4	728	c.387C>T	c.(385-387)ttC>ttT	p.F129F	YTHDF1_ENST00000370334.4_Intron|YTHDF1_ENST00000370333.4_Silent_p.F79F	NM_017798.3	NP_060268.2	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	129										NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)	24						CCCATGCTGAGAACGCAGGGT	0.567000													24	49					0	0	0.002780	0	0
ADAM23	8745	broad.mit.edu	37	2	207310197	207310197	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:207310197C>T	ENST00000264377.3	+	2	709	c.381C>T	c.(379-381)agC>agT	p.S127S	ADAM23_ENST00000374415.3_Silent_p.S127S|ADAM23_ENST00000374416.1_Silent_p.S127S	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	127					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		ACTCGGAAAGCCCTTATCACG	0.403000													22	134					0	0	0.002780	0	0
CDH22	64405	broad.mit.edu	37	20	44869675	44869675	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:44869675C>T	ENST00000372262.3	-	2	877	c.477G>A	c.(475-477)caG>caA	p.Q159Q	CDH22_ENST00000537909.1_Silent_p.Q159Q	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	159	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				CATTGATGTCCTGCACCTTGA	0.647000													16	100					0	0	0.007413	0	0
MRO	83876	broad.mit.edu	37	18	48333212	48333212	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:48333212C>T	ENST00000428869.2	-	5	366	c.108G>A	c.(106-108)tgG>tgA	p.W36*	MRO_ENST00000431965.2_Nonsense_Mutation_p.W50*|MRO_ENST00000398439.3_Nonsense_Mutation_p.W36*|MRO_ENST00000436348.2_Nonsense_Mutation_p.W50*|MRO_ENST00000256425.2_Nonsense_Mutation_p.W36*|MRO_ENST00000587291.1_Intron|MRO_ENST00000588444.1_Nonsense_Mutation_p.W36*			Q9BYG7	MSTRO_HUMAN	maestro	36						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		ACCTCAGTTTCCAAGAGACCT	0.468000													18	108					0	0	0.008871	0	0
CHAT	1103	broad.mit.edu	37	10	50859978	50859978	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:50859978G>A	ENST00000395562.2	+	12	1783	c.1314G>A	c.(1312-1314)ggG>ggA	p.G438G	CHAT_ENST00000455728.2_Silent_p.G402G|CHAT_ENST00000337653.2_Silent_p.G520G|CHAT_ENST00000351556.3_Silent_p.G402G|CHAT_ENST00000395559.2_Silent_p.G402G|CHAT_ENST00000339797.1_Silent_p.G402G	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	520					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity	p.G520G(1)		central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	ACAACTATGGGAAAACATTCA	0.413000													5	26					0	0	0.000602	0	0
TFCP2L1	29842	broad.mit.edu	37	2	122005761	122005761	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:122005761C>T	ENST00000263707.5	-	5	580	c.483G>A	c.(481-483)aaG>aaA	p.K161K		NM_014553.2	NP_055368.1	Q9NZI6	TF2L1_HUMAN	transcription factor CP2-like 1	161					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)|pancreas(2)|skin(1)|stomach(1)	22	Renal(3;0.01)					CAGAAGCTCTCTTCGCAGGGT	0.552000													4	30					0	0	0.009096	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42129028	42129028	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:42129028C>T	ENST00000542534.1	+	7	792	c.752C>T	c.(751-753)cCt>cTt	p.P251L	JMJD7-PLA2G4B_ENST00000476036.1_Intron|JMJD7_ENST00000397299.4_Missense_Mutation_p.P251L|JMJD7-PLA2G4B_ENST00000342159.4_Intron|JMJD7-PLA2G4B_ENST00000382448.4_Intron|JMJD7_ENST00000408047.1_Missense_Mutation_p.P152L	NM_001114632.1	NP_001108104.1	P0C869	PA24B_HUMAN		0	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						GCACGGTACCCTAGTTACAGT	0.657000													8	21					0	0	0.004482	0	0
SOS2	6655	broad.mit.edu	37	14	50649216	50649216	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:50649216G>A	ENST00000216373.5	-	6	1097	c.823C>T	c.(823-825)Ccc>Tcc	p.P275S	SOS2_ENST00000543680.1_Missense_Mutation_p.P275S	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	275	DH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					CCAGCTAAGGGATGAGGACTG	0.333000													8	28					0	0	0.008291	0	0
PLXNA4	91584	broad.mit.edu	37	7	131865476	131865476	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:131865476G>A	ENST00000359827.3	-	19	4470	c.3508C>T	c.(3508-3510)Ccg>Tcg	p.P1170S	PLXNA4_ENST00000321063.4_Missense_Mutation_p.P1170S			Q9HCM2	PLXA4_HUMAN	plexin A4	1170	IPT/TIG 4.					integral to membrane|intracellular|plasma membrane		p.P1170S(1)		NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GCCACAGGCGGGATCAGGTTC	0.597000													9	45					0	0	0.010729	0	0
DNHD1	144132	broad.mit.edu	37	11	6519800	6519800	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:6519800C>T	ENST00000254579.6	+	3	919	c.355C>T	c.(355-357)Caa>Taa	p.Q119*	DNHD1_ENST00000354685.3_Nonsense_Mutation_p.Q119*|DNHD1_ENST00000527990.2_Nonsense_Mutation_p.Q119*|DNHD1_ENST00000477562.1_3'UTR	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	119					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ACCCTGGGTCCAAACCCACCT	0.562000													18	136					0	0	0.006122	0	0
RGR	5995	broad.mit.edu	37	10	86017671	86017671	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:86017671G>A	ENST00000359452.4	+	6	703	c.665G>A	c.(664-666)aGg>aAg	p.R222K	RGR_ENST00000479725.1_3'UTR|RGR_ENST00000358110.5_Intron	NM_001012720.1|NM_002921.3	NP_001012738.1|NP_002912.2	P47804	RGR_HUMAN	retinal G protein coupled receptor	218					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	17						CTGCCAGCAAGGACGCTGCTG	0.552000													7	46					0	0	0.006214	0	0
PXDNL	137902	broad.mit.edu	37	8	52320904	52320904	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:52320904C>T	ENST00000356297.4	-	17	3380	c.3280G>A	c.(3280-3282)Gaa>Aaa	p.E1094K	PXDNL_ENST00000543296.1_Missense_Mutation_p.E1094K	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1094					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ATCCCACCTTCCTTGATTATT	0.532000													13	60					0	0	0.002450	0	0
KRT34	3885	broad.mit.edu	37	17	39535632	39535632	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:39535632C>T	ENST00000394001.1	-	5	1005	c.975G>A	c.(973-975)gaG>gaA	p.E325E		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	325	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				GCAGCTCGATCTCCAGGGCGT	0.607000													9	67					0	0	0.006214	0	0
NWD1	284434	broad.mit.edu	37	19	16918857	16918857	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:16918857G>A	ENST00000524140.2	+	18	4615	c.4197G>A	c.(4195-4197)aaG>aaA	p.K1399K	NWD1_ENST00000552788.1_Silent_p.K1399K|NWD1_ENST00000549814.1_Silent_p.K1357K|NWD1_ENST00000379808.3_Silent_p.K1399K|NWD1_ENST00000339803.6_Silent_p.K1264K|NWD1_ENST00000523826.1_Silent_p.K1193K	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1399				K -> R (in Ref. 1; CAH18655).			ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCAGCCACAAGGAGCAGCTGG	0.582000													12	100					0	0	0.001855	0	0
NLRP2	55655	broad.mit.edu	37	19	55496462	55496462	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:55496462C>T	ENST00000543010.1	+	7	2221	c.2078C>T	c.(2077-2079)tCc>tTc	p.S693F	NLRP2_ENST00000448584.2_Missense_Mutation_p.S693F|NLRP2_ENST00000427260.2_Missense_Mutation_p.S670F|NLRP2_ENST00000391721.4_Missense_Mutation_p.S669F|NLRP2_ENST00000339757.7_Missense_Mutation_p.S671F|NLRP2_ENST00000263437.6_Missense_Mutation_p.S690F|NLRP2_ENST00000538819.1_Missense_Mutation_p.S669F|NLRP2_ENST00000537859.1_Missense_Mutation_p.S671F	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	693					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GACCTTTGTTCCATATTTGGA	0.448000													20	90					0	0	0.008871	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54913059	54913059	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:54913059G>A	ENST00000293373.6	+	16	1647	c.1568G>A	c.(1567-1569)cGa>cAa	p.R523Q	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.R473Q	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	523					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TTCCACTCCCGAATGCTGGAC	0.468000													13	59					0	0	0.013537	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37419225	37419225	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:37419225C>T	ENST00000374660.1	+	3	360	c.261C>T	c.(259-261)ctC>ctT	p.L87L	ANKRD30A_ENST00000361713.1_Silent_p.L87L|ANKRD30A_ENST00000602533.1_Silent_p.L87L			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	143						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ACACGGCTCTCCATTATGCTG	0.443000													3	21					0	0	0.009096	0	0
ENOX1	55068	broad.mit.edu	37	13	43935540	43935540	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:43935540C>T	ENST00000261488.6	-	6	834	c.257G>A	c.(256-258)gGa>gAa	p.G86E	ENOX1_ENST00000412891.1_Missense_Mutation_p.G86E	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	86					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GGGGGTGATTCCAGTCATCAT	0.433000													9	70					0	0	0.010729	0	0
HOXD3	3232	broad.mit.edu	37	2	177036879	177036879	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:177036879C>T	ENST00000468418.3	+	4	3266	c.1176C>T	c.(1174-1176)gcC>gcT	p.A392A	HOXD3_ENST00000410016.1_Silent_p.A392A|HOXD3_ENST00000249440.3_Silent_p.A392A			P31249	HXD3_HUMAN	homeobox D3	392					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		ACAGTTGCGCCGCGCAGATTC	0.662000													4	30					0	0	0.001168	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20905384	20905384	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:20905384A>T	ENST00000381552.1	+	15	2532	c.2164A>T	c.(2164-2166)Att>Ttt	p.I722F	SLCO1C1_ENST00000266509.2_Missense_Mutation_p.R687S|SLCO1C1_ENST00000540354.1_Missense_Mutation_p.R638S|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.I604F|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.I722F			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	0					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TGTCTACAAGATTCCAAAAGG	0.348000													4	16					0	0	0.000602	0	0
TELO2	9894	broad.mit.edu	37	16	1551694	1551694	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:1551694C>T	ENST00000262319.6	+	11	1671	c.1392C>T	c.(1390-1392)ccC>ccT	p.P464P		NM_016111.3	NP_057195.2	Q9Y4R8	TELO2_HUMAN	telomere maintenance 2	464						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding			NS(1)|endometrium(1)|kidney(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	19		Hepatocellular(780;0.219)				CGGCAGAGCCCCCTGCAGAGA	0.627000													11	70					0	0	0.002450	0	0
CDK19	23097	broad.mit.edu	37	6	110953310	110953310	+	Nonsense_Mutation	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:110953310A>T	ENST00000368911.3	-	6	748	c.569T>A	c.(568-570)tTg>tAg	p.L190*	CDK19_ENST00000323817.3_Nonsense_Mutation_p.L130*|CDK19_ENST00000413605.2_Nonsense_Mutation_p.L66*	NM_015076.3	NP_055891.1	Q9BWU1	CDK19_HUMAN	cyclin-dependent kinase 19	190	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)	22						TACTGGATCCAAATCTGCTAG	0.348000													9	44					0	0	0.006214	0	0
CRB1	23418	broad.mit.edu	37	1	197297845	197297845	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:197297845G>A	ENST00000367400.3	+	2	499	c.364G>A	c.(364-366)Gga>Aga	p.G122R	CRB1_ENST00000535699.1_Missense_Mutation_p.G53R|CRB1_ENST00000367399.2_Missense_Mutation_p.G122R|CRB1_ENST00000538660.1_Missense_Mutation_p.G122R	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	122	EGF-like 3.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CTGCCAACATGGAGGTATTTG	0.493000													5	26					0	0	0.000602	0	0
L3MBTL4	91133	broad.mit.edu	37	18	5969550	5969550	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:5969550C>T	ENST00000284898.6	-	18	1683	c.1483G>A	c.(1483-1485)Gag>Aag	p.E495K	L3MBTL4_ENST00000317931.7_Missense_Mutation_p.E486K|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.E495K|L3MBTL4_ENST00000535782.1_Missense_Mutation_p.E299K	NM_173464.3	NP_775735.2	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	495					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				TGCGCCTGCTCCACCGAGTAT	0.622000													15	29					0	0	0.004990	0	0
TMEM105	284186	broad.mit.edu	37	17	79287683	79287683	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:79287683C>T	ENST00000332900.1	-	3	707	c.158G>A	c.(157-159)aGg>aAg	p.R53K		NM_178520.3	NP_848615.1	Q8N8V8	TM105_HUMAN	transmembrane protein 105	53						integral to membrane				NS(1)|large_intestine(3)|lung(1)|ovary(2)	7	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			GGGAGACGTCCTCGGGCCCTG	0.607000													24	106					0	0	0.003330	0	0
AHNAK2	113146	broad.mit.edu	37	14	105408105	105408105	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:105408105G>A	ENST00000333244.5	-	7	13802	c.13683C>T	c.(13681-13683)ctC>ctT	p.L4561L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4561						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGGGCCCTTGAGGTCCACTT	0.617000													44	215					0	0	0.014410	0	0
CACNG3	10368	broad.mit.edu	37	16	24373037	24373037	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:24373037C>T	ENST00000005284.3	+	4	2003	c.801C>T	c.(799-801)ctC>ctT	p.L267L		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	267					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		TGTTCACCCTCTCCCGGGACC	0.567000													19	95					0	0	0.012319	0	0
CDC42EP4	23580	broad.mit.edu	37	17	71281578	71281578	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:71281578G>A	ENST00000335793.3	-	2	1456	c.1062C>T	c.(1060-1062)atC>atT	p.I354I	CDC42EP4_ENST00000439510.2_Silent_p.I284I|CDC42EP4_ENST00000581014.1_3'UTR			Q9H3Q1	BORG4_HUMAN	CDC42 effector protein (Rho GTPase binding) 4	354					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(7)|urinary_tract(1)	14			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			CTCACACACGGATTTCATCCT	0.642000													25	80					0	0	0.006320	0	0
PSG7	5676	broad.mit.edu	37	19	43439767	43439767	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:43439767C>T	ENST00000446844.3	-	0	308				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GGTAGAGGTCCCTGATTTGTC	0.428000													41	165					0	0	0.006999	0	0
LDLRAD4	753	broad.mit.edu	37	18	13438253	13438253	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:13438253C>T	ENST00000361205.4	+	4	719	c.51C>T	c.(49-51)ttC>ttT	p.F17F	LDLRAD4_ENST00000399848.3_Silent_p.F17F|LDLRAD4_ENST00000359446.5_Silent_p.F17F	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4																		AGTGCAAATTCACCTGCACCA	0.458000													12	53					0	0	0.010729	0	0
NXF1	10482	broad.mit.edu	37	11	62563933	62563933	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:62563933G>A	ENST00000532297.1	-	15	1914	c.1286_splice	c.e15+1	p.R429_splice	NXF1_ENST00000531709.2_3'UTR|NXF1_ENST00000294172.2_Splice_Site_p.R429_splice			Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1	429	NTF2.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GATACTAACCGGGCAGGGTTC	0.562000													22	64					0	0	0.004656	0	0
MUC16	94025	broad.mit.edu	37	19	9060457	9060457	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9060457T>C	ENST00000397910.4	-	3	27192	c.26989A>G	c.(26989-26991)Aca>Gca	p.T8997A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8999	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGGTGGATGTTGACTCCATC	0.498000													28	94					0	0	0.010818	0	0
CCDC94	55702	broad.mit.edu	37	19	4267768	4267768	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:4267768C>T	ENST00000262962.7	+	7	924	c.856C>T	c.(856-858)Cca>Tca	p.P286S		NM_018074.4	NP_060544.2	Q9BW85	CCD94_HUMAN	coiled-coil domain containing 94	286										NS(1)|endometrium(1)|lung(2)|ovary(1)|stomach(2)	7				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)		GGCCCCCACCCCAGGTAAGGT	0.657000											OREG0025164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	10					0	0	0.004672	0	0
FGA	2243	broad.mit.edu	37	4	155505387	155505387	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:155505387C>T	ENST00000302053.3	-	6	2568	c.2490G>A	c.(2488-2490)agG>agA	p.R830R		NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	830	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GACTGTTATTCCTTGGGTCAT	0.488000													27	102					0	0	0.005443	0	0
ZNF560	147741	broad.mit.edu	37	19	9577729	9577729	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9577729C>T	ENST00000301480.4	-	10	2107	c.1894G>A	c.(1894-1896)Gac>Aac	p.D632N		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TTCCCACAGTCCTTATATTCA	0.378000													17	75					0	0	0.006122	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073323	17073323	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:17073323C>T	ENST00000359963.3	-	1	377	c.118G>A	c.(118-120)Gtc>Atc	p.V40I		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	40					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGGGTCTGGACTGCAGCCAAG	0.642000													14	58					0	0	0.003163	0	0
EPPK1	83481	broad.mit.edu	37	8	144945289	144945289	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:144945289G>A	ENST00000525985.1	-	2	2204	c.2133C>T	c.(2131-2133)atC>atT	p.I711I				P58107	EPIPL_HUMAN	epiplakin 1	711						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTCCCGGACGATGAGGCCCT	0.687000													16	69					0	0	0.004990	0	0
FAT3	120114	broad.mit.edu	37	11	92616244	92616244	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:92616244C>T	ENST00000298047.6	+	23	12639	c.12622C>T	c.(12622-12624)Ccg>Tcg	p.P4208S	FAT3_ENST00000409404.2_Missense_Mutation_p.P4208S|FAT3_ENST00000525166.1_Missense_Mutation_p.P4058S|FAT3_ENST00000533797.1_Missense_Mutation_p.P543S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4208					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAATGGCATCCCGTTCCGGAA	0.652000										TCGA Ovarian(4;0.039)			72	299					0	0	0.014410	0	0
CDYL2	124359	broad.mit.edu	37	16	80654830	80654830	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:80654830G>A	ENST00000299564.8	-	4	992	c.837C>T	c.(835-837)atC>atT	p.I279I	CDYL2_ENST00000562812.1_Silent_p.I280I|CDYL2_ENST00000563890.1_Silent_p.I280I|CDYL2_ENST00000566173.1_Silent_p.I280I	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	279						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						CTTCTTTCATGATCTGCCGGC	0.582000													3	11					0	0	0.009096	0	0
MACC1	346389	broad.mit.edu	37	7	20193960	20193960	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:20193960G>A	ENST00000400331.5	-	6	2510	c.2202C>T	c.(2200-2202)atC>atT	p.I734I	MACC1_ENST00000589011.1_Silent_p.I734I|MACC1_ENST00000332878.4_Silent_p.I734I	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	734					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						CAGCTTCTTGGATGAGACGTG	0.438000													4	43					0	0	0.009096	0	0
SGCE	8910	broad.mit.edu	37	7	94230004	94230004	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:94230004G>A	ENST00000415788.2	-	8	1186	c.1099C>T	c.(1099-1101)Ctt>Ttt	p.L367F	SGCE_ENST00000437425.2_Missense_Mutation_p.L290F|SGCE_ENST00000428696.2_Missense_Mutation_p.L331F|SGCE_ENST00000265735.7_Missense_Mutation_p.L331F|SGCE_ENST00000445866.2_Missense_Mutation_p.L331F|SGCE_ENST00000447873.1_Missense_Mutation_p.L331F			O43556	SGCE_HUMAN	sarcoglycan, epsilon	331					cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|skin(1)	14	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			ATTAGAAAAAGGACCAGTGCC	0.418000													10	34					0	0	0.001855	0	0
PCLO	27445	broad.mit.edu	37	7	82764839	82764839	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:82764839G>A	ENST00000423517.2	-	3	2364	c.2027C>T	c.(2026-2028)tCc>tTc	p.S676F	PCLO_ENST00000333891.8_Missense_Mutation_p.S676F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	622	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGGCTGTGGGGATGATTTGCT	0.522000													18	48					0	0	0.007413	0	0
C8B	732	broad.mit.edu	37	1	57415272	57415272	+	Nonsense_Mutation	SNP	G	G	A	rs140813121	by1000genomes	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:57415272G>A	ENST00000543257.1	-	7	1230	c.664C>T	c.(664-666)Cga>Tga	p.R222*	C8B_ENST00000535057.1_Nonsense_Mutation_p.R212*|C8B_ENST00000371237.4_Nonsense_Mutation_p.R274*	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	274	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGTTTGCCTCGATCACTTTGA	0.363000													6	35					0	0	0.001168	0	0
NFRKB	4798	broad.mit.edu	37	11	129748408	129748408	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:129748408G>A	ENST00000446488.3	-	13	1518	c.1415C>T	c.(1414-1416)gCt>gTt	p.A472V	NFRKB_ENST00000524794.1_Missense_Mutation_p.A497V|NFRKB_ENST00000524746.1_Missense_Mutation_p.A472V|NFRKB_ENST00000304521.5_Missense_Mutation_p.A472V	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	472					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GAAGAGGGCAGCTAATTCCTT	0.383000													33	153					0	0	0.009718	0	0
LBX1	10660	broad.mit.edu	37	10	102987042	102987042	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:102987042G>A	ENST00000370193.2	-	2	1809	c.831C>T	c.(829-831)atC>atT	p.I277I		NM_006562.4	NP_006553.2	P52954	LBX1_HUMAN	ladybird homeobox 1	277	Asp/Glu-rich (highly acidic).				muscle organ development		sequence-specific DNA binding			large_intestine(2)|lung(4)|ovary(1)	7		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)		CGTCCACGTCGATCTCTTCGT	0.726000													44	143					0	0	0.014410	0	0
ASPM	259266	broad.mit.edu	37	1	197060024	197060024	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:197060024G>A	ENST00000367409.4	-	23	9848	c.9592C>T	c.(9592-9594)Cgt>Tgt	p.R3198C	ASPM_ENST00000367408.1_Missense_Mutation_p.R863C|ASPM_ENST00000294732.7_Missense_Mutation_p.R1613C	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	3198	IQ 38.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TGCTTTTTACGGAGGAGAAAA	0.358000													12	60					0	0	0.002450	0	0
IGDCC4	57722	broad.mit.edu	37	15	65676746	65676746	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:65676746C>T	ENST00000352385.2	-	20	3563	c.3354G>A	c.(3352-3354)agG>agA	p.R1118R	IGDCC4_ENST00000558048.1_5'UTR	NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1118						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						GTGACTTCTTCCTCCCATTGC	0.512000													24	133					0	0	0.003330	0	0
KLC2	64837	broad.mit.edu	37	11	66030323	66030323	+	Missense_Mutation	SNP	G	G	A	rs140572929		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:66030323G>A	ENST00000394065.2	+	3	1169	c.151G>A	c.(151-153)Ggg>Agg	p.G51R	KLC2_ENST00000316924.5_Missense_Mutation_p.G190R|KLC2_ENST00000394067.2_Missense_Mutation_p.G190R|KLC2_ENST00000417856.1_Missense_Mutation_p.G190R|KLC2_ENST00000421552.1_Missense_Mutation_p.G113R|KLC2_ENST00000394066.2_Missense_Mutation_p.G113R|KLC2_ENST00000394078.1_Missense_Mutation_p.G190R			Q9H0B6	KLC2_HUMAN	kinesin light chain 2	190					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						TGGTCAGCATGGGGGCTACGA	0.637000													15	97					0	0	0.004990	0	0
FCRL4	83417	broad.mit.edu	37	1	157557143	157557143	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:157557143C>T	ENST00000271532.1	-	5	905	c.770G>A	c.(769-771)gGa>gAa	p.G257E	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	257	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				CCAATAGGATCCTGAGTTTTC	0.537000													73	291					0	0	0.014410	0	0
EGFLAM	133584	broad.mit.edu	37	5	38418357	38418357	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:38418357G>A	ENST00000322350.5	+	12	2030	c.1684_splice	c.e12+1	p.G562_splice	EGFLAM_ENST00000354891.3_Splice_Site_p.G562_splice|EGFLAM_ENST00000336740.6_Splice_Site_p.G328_splice|EGFLAM_ENST00000397202.2_Intron	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	562	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GGCTGATGTGGGTAAGTGGCT	0.567000													6	28					0	0	0.001168	0	0
FLG2	388698	broad.mit.edu	37	1	152329028	152329028	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:152329028C>T	ENST00000388718.5	-	3	1306	c.1234G>A	c.(1234-1236)Gaa>Aaa	p.E412K	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	412	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGGAAAATTCATTTGAACTA	0.428000													22	100					0	0	0.003330	0	0
ZC3H12D	340152	broad.mit.edu	37	6	149777843	149777843	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:149777843G>A	ENST00000389942.5	-	4	886	c.639C>T	c.(637-639)ttC>ttT	p.F213F	ZC3H12D_ENST00000416573.2_Silent_p.F213F|ZC3H12D_ENST00000409806.3_Silent_p.F213F|ZC3H12D_ENST00000542614.1_Silent_p.F213F			A2A288	ZC12D_HUMAN	zinc finger CCCH-type containing 12D	213						cytoplasm|nucleus	endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	6		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.23e-11)|GBM - Glioblastoma multiforme(68;0.0921)		TCTGCTCGATGAACCACTTCC	0.657000													18	73					0	0	0.008871	0	0
UCP3	7352	broad.mit.edu	37	11	73717239	73717239	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:73717239C>T	ENST00000314032.4	-	3	864	c.312G>A	c.(310-312)caG>caA	p.Q104Q	UCP3_ENST00000348534.4_Silent_p.Q104Q|UCP3_ENST00000426995.2_Silent_p.Q104Q	NM_003356.3	NP_003347.1	P55916	UCP3_HUMAN	uncoupling protein 3 (mitochondrial, proton carrier)	104					mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	12	Breast(11;2.08e-05)					GGGTGTACACCTGCTTGACGG	0.612000													13	58					0	0	0.003163	0	0
DDRGK1	65992	broad.mit.edu	37	20	3171860	3171860	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:3171860G>A	ENST00000354488.3	-	8	811	c.754C>T	c.(754-756)Ctg>Ttg	p.L252L	DDRGK1_ENST00000496781.1_5'UTR	NM_023935.1	NP_076424.1	Q96HY6	DDRGK_HUMAN	DDRGK domain containing 1	252	PCI.					endoplasmic reticulum	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(1)	7						TCAGCCAGCAGGTCCTGGATG	0.527000													14	60					0	0	0.004990	0	0
GP2	2813	broad.mit.edu	37	16	20335417	20335417	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:20335417C>T	ENST00000302555.5	-	3	405	c.256G>A	c.(256-258)Gat>Aat	p.D86N	GP2_ENST00000381360.5_Intron|GP2_ENST00000341642.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.D86N			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	86						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						ATGTTTTTATCGCACCCCTGG	0.562000													16	63					0	0	0.007413	0	0
GABRB3	2562	broad.mit.edu	37	15	26793211	26793211	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:26793211C>T	ENST00000541819.2	-	10	1421	c.1319G>A	c.(1318-1320)gGc>gAc	p.G440D	GABRB3_ENST00000545868.1_Missense_Mutation_p.G299D|GABRB3_ENST00000400188.3_Missense_Mutation_p.G313D|GABRB3_ENST00000299267.4_Missense_Mutation_p.G384D|GABRB3_ENST00000311550.5_Missense_Mutation_p.G384D			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	384					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATCGCCAATGCCGCCTGAGAC	0.473000													17	90					0	0	0.007413	0	0
SP140	11262	broad.mit.edu	37	2	231155266	231155266	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:231155266G>A	ENST00000392045.3	+	19	1926	c.1812G>A	c.(1810-1812)aaG>aaA	p.K604K	SP140_ENST00000417495.3_Silent_p.K490K|SP140_ENST00000350136.5_Silent_p.K473K|SP140_ENST00000420434.3_Silent_p.K577K|SP140_ENST00000486687.2_Silent_p.K528K|SP140_ENST00000343805.6_Silent_p.K544K	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	604	SAND.				defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TACATAAGAAGAAATTGCAGC	0.398000													8	44					0	0	0.004482	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073418	17073418	+	Missense_Mutation	SNP	G	G	A	rs148171132		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:17073418G>A	ENST00000359963.3	-	1	282	c.23C>T	c.(22-24)gCc>gTc	p.A8V		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	8					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CAGCTCCAGGGCTGAAGGGAC	0.642000													9	48					0	0	0.006214	0	0
RNF19A	25897	broad.mit.edu	37	8	101276405	101276405	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:101276405A>G	ENST00000519449.1	-	8	1641	c.1325T>C	c.(1324-1326)aTg>aCg	p.M442T	RNF19A_ENST00000341084.2_Missense_Mutation_p.M442T|RNF19A_ENST00000523255.1_Intron	NM_015435.3	NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	442					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			ATAAGCTAACATAATAGGAAC	0.358000													4	21					0	0	0.000602	0	0
ZDHHC19	131540	broad.mit.edu	37	3	195937578	195937578	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:195937578C>T	ENST00000296326.3	-	2	256	c.177G>A	c.(175-177)tgG>tgA	p.W59*	ZDHHC19_ENST00000488508.1_5'UTR	NM_001039617.1	NP_001034706.1	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC-type containing 19	59						integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(7)|ovary(3)	14	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		CAGGAAAGGCCCACTCCCCGT	0.577000													5	34					0	0	0.000602	0	0
ITGA7	3679	broad.mit.edu	37	12	56094742	56094742	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:56094742G>A	ENST00000257880.7	-	4	830	c.611C>T	c.(610-612)gCc>gTc	p.A204V	ITGA7_ENST00000394229.2_Missense_Mutation_p.A204V|ITGA7_ENST00000452168.2_Missense_Mutation_p.A107V|ITGA7_ENST00000257879.6_Missense_Mutation_p.A204V|ITGA7_ENST00000347027.6_Missense_Mutation_p.A204V|ITGA7_ENST00000394230.2_Missense_Mutation_p.A204V|ITGA7_ENST00000553804.1_Missense_Mutation_p.A204V|ITGA7_ENST00000555728.1_Missense_Mutation_p.A204V			Q13683	ITA7_HUMAN	integrin, alpha 7	204					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						AGGGGAGAAGGCGGCAGCTGT	0.582000													9	37					0	0	0.004482	0	0
OR6C75	390323	broad.mit.edu	37	12	55759353	55759353	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:55759353C>T	ENST00000343399.3	+	1	459	c.459C>T	c.(457-459)atC>atT	p.I153I		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I153I(1)		endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						GGTTTCTGATCATCTTTCCAC	0.453000													8	42					0	0	0.003080	0	0
LARP1B	55132	broad.mit.edu	37	4	129035873	129035873	+	Silent	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:129035873T>C	ENST00000326639.6	+	10	1348	c.1137T>C	c.(1135-1137)caT>caC	p.H379H	LARP1B_ENST00000441387.1_Silent_p.H379H|LARP1B_ENST00000264584.5_Silent_p.H332H|LARP1B_ENST00000427266.1_Silent_p.H379H|LARP1B_ENST00000512292.1_Silent_p.H379H|LARP1B_ENST00000354456.3_5'UTR	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	379							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						AAAAAAGACATCAGCCAGCCC	0.413000													7	47					0	0	0.001984	0	0
CDHR3	222256	broad.mit.edu	37	7	105615411	105615411	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:105615411C>T	ENST00000542731.1	+	2	276	c.168C>T	c.(166-168)atC>atT	p.I56I	CDHR3_ENST00000478080.1_Intron|CDHR3_ENST00000343407.5_5'UTR|CDHR3_ENST00000470188.1_3'UTR|CDHR3_ENST00000541203.1_Silent_p.I56I|CDHR3_ENST00000317716.9_Silent_p.I56I			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	56	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						CACCTGTGATCCCAGGATTTC	0.458000													53	131					0	0	0.014410	0	0
FAM83G	644815	broad.mit.edu	37	17	18882883	18882883	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:18882883C>T	ENST00000388995.6	-	4	1017	c.794G>A	c.(793-795)cGg>cAg	p.R265Q	SLC5A10_ENST00000317977.6_Intron|SLC5A10_ENST00000417251.2_Intron|SLC5A10_ENST00000395645.3_Intron|FAM83G_ENST00000345041.4_Missense_Mutation_p.R265Q|FAM83G_ENST00000585154.2_Missense_Mutation_p.R265Q|SLC5A10_ENST00000395643.2_Intron|SLC5A10_ENST00000395642.1_Intron|SLC5A10_ENST00000395647.2_Intron			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	265										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						GCACACAGCCCGGTCTCCATC	0.582000													10	43					0	0	0.008291	0	0
FBXL17	64839	broad.mit.edu	37	5	107216831	107216831	+	Silent	SNP	G	G	A	rs143348449	byFrequency	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:107216831G>A	ENST00000542267.1	-	8	2278	c.1872C>T	c.(1870-1872)gtC>gtT	p.V624V	FBXL17_ENST00000496714.1_Silent_p.V226V|FBXL17_ENST00000359660.5_Silent_p.V226V	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	624										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		TACACCATCCGACATCCACAG	0.468000													15	86					0	0	0.003163	0	0
ZNF282	8427	broad.mit.edu	37	7	148892733	148892733	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:148892733C>T	ENST00000262085.3	+	1	157	c.52C>T	c.(52-54)Ctg>Ttg	p.L18L	ZNF282_ENST00000479907.1_Silent_p.L18L	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	18					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CATCCAGGGCCTGGGGCTGGA	0.687000													7	27					0	0	0.003080	0	0
ANKS1A	23294	broad.mit.edu	37	6	34949592	34949592	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:34949592C>T	ENST00000360359.3	+	4	699	c.561C>T	c.(559-561)gaC>gaT	p.D187D	ANKS1A_ENST00000535627.1_Silent_p.D187D	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	187						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						CCCCTTTGGACCTGGCAGCAC	0.557000													17	97					0	0	0.008871	0	0
MCM10	55388	broad.mit.edu	37	10	13234455	13234455	+	Silent	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:13234455T>C	ENST00000378694.1	+	12	1707	c.1632T>C	c.(1630-1632)atT>atC	p.I544I	MCM10_ENST00000484800.2_Silent_p.I545I|MCM10_ENST00000378714.3_Silent_p.I544I			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	545					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						TTTCAGGGATTATGGGGAGCC	0.557000													18	62					0	0	0.012319	0	0
LAMA3	3909	broad.mit.edu	37	18	21487612	21487612	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:21487612C>T	ENST00000313654.9	+	53	7058	c.6817C>T	c.(6817-6819)Ctt>Ttt	p.L2273F	LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Missense_Mutation_p.L608F|LAMA3_ENST00000399516.3_Missense_Mutation_p.L2217F|LAMA3_ENST00000269217.6_Missense_Mutation_p.L664F	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2273	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCGAGATGGTCTTCATGGGAT	0.428000													20	102					0	0	0.008871	0	0
BCAR3	8412	broad.mit.edu	37	1	94048307	94048307	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:94048307G>A	ENST00000370244.1	-	9	1525	c.1237C>T	c.(1237-1239)Ctc>Ttc	p.L413F	BCAR3_ENST00000370247.3_Missense_Mutation_p.L322F|BCAR3_ENST00000539242.1_Missense_Mutation_p.L89F|BCAR3_ENST00000370243.1_Missense_Mutation_p.L413F|BCAR3_ENST00000260502.6_Missense_Mutation_p.L413F|BCAR3_ENST00000466632.1_5'UTR	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	413					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		GGAACCTTGAGGAACGGCACC	0.627000													12	61					0	0	0.002450	0	0
HCLS1	3059	broad.mit.edu	37	3	121350951	121350951	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:121350951C>T	ENST00000314583.3	-	13	1412	c.1321G>A	c.(1321-1323)Gga>Aga	p.G441R	HCLS1_ENST00000428394.2_Missense_Mutation_p.G404R|HCLS1_ENST00000473883.1_5'UTR	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	441	SH3.				erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		AACCTACCTCCTTGGTAATCA	0.537000													18	131					0	0	0.006122	0	0
BTNL3	10917	broad.mit.edu	37	5	180424345	180424345	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:180424345C>T	ENST00000342868.6	+	3	714	c.530C>T	c.(529-531)tCa>tTa	p.S177L		NM_197975.2	NP_932079.1	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3	177	Ig-like V-type.				lipid metabolic process	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(10)|prostate(2)|skin(1)	25	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GATTTGTCTTCAGACTCCAGA	0.502000													8	28					0	0	0.003080	0	0
SYNE1	23345	broad.mit.edu	37	6	152826376	152826376	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:152826376G>A	ENST00000367255.5	-	9	1339	c.738C>T	c.(736-738)gcC>gcT	p.A246A	SYNE1_ENST00000423061.1_Silent_p.A253A|SYNE1_ENST00000367248.3_Silent_p.A253A|SYNE1_ENST00000367253.4_Silent_p.A246A|SYNE1_ENST00000413186.2_Silent_p.A246A|SYNE1_ENST00000265368.4_Silent_p.A246A|SYNE1_ENST00000466159.2_Silent_p.A246A|SYNE1_ENST00000341594.5_Silent_p.A246A|SYNE1_ENST00000448038.1_Silent_p.A253A	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	246	Actin-binding.|CH 2.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTTCTGTTTCGGCGATAGTGA	0.428000										HNSCC(10;0.0054)			8	80					0	0	0.006214	0	0
ANK1	286	broad.mit.edu	37	8	41571742	41571742	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:41571742G>A	ENST00000396942.1	-	16	1815	c.1732C>T	c.(1732-1734)Cat>Tat	p.H578Y	ANK1_ENST00000379758.2_Missense_Mutation_p.H578Y|ANK1_ENST00000289734.7_Missense_Mutation_p.H578Y|ANK1_ENST00000396945.1_Missense_Mutation_p.H578Y|ANK1_ENST00000352337.4_Missense_Mutation_p.H578Y|ANK1_ENST00000265709.8_Missense_Mutation_p.H611Y|ANK1_ENST00000347528.4_Missense_Mutation_p.H578Y			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	578	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TTGTTGTGATGGACGGCCACG	0.657000													8	39					0	0	0.006214	0	0
TENM3	55714	broad.mit.edu	37	4	183675559	183675559	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:183675559G>A	ENST00000511685.1	+	22	4162	c.4039G>A	c.(4039-4041)Gac>Aac	p.D1347N	TENM3_ENST00000406950.2_Missense_Mutation_p.D1347N|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		ATGGCCCACTGACCTAGCCAT	0.398000													6	14					0	0	0.001168	0	0
CHST10	9486	broad.mit.edu	37	2	101014497	101014497	+	Silent	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:101014497G>T	ENST00000264249.3	-	5	685	c.300C>A	c.(298-300)ctC>ctA	p.L100L	CHST10_ENST00000542617.1_Silent_p.L148L|CHST10_ENST00000409701.1_Silent_p.L100L	NM_004854.4	NP_004845.1	O43529	CHSTA_HUMAN	carbohydrate sulfotransferase 10	100					carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)	16						GAGTGTGCGAGAGATTCTTCA	0.527000													20	102					9.95505e-16	1.04272e-15	0.014323	1	0
MROH9	80133	broad.mit.edu	37	1	170914708	170914708	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:170914708G>A	ENST00000367759.4	+	2	165	c.11G>A	c.(10-12)aGg>aAg	p.R4K	MROH9_ENST00000367758.3_Missense_Mutation_p.R4K	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		ATGTTGACAAGGAATCCAAAA	0.358000													4	20					0	0	0.000602	0	0
SPDYC	387778	broad.mit.edu	37	11	64940289	64940289	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:64940289C>T	ENST00000377185.2	+	6	733	c.651C>T	c.(649-651)tcC>tcT	p.S217S		NM_001008778.1	NP_001008778.1	Q5MJ68	SPDYC_HUMAN	speedy/RINGO cell cycle regulator family member C	217					cell cycle	nucleus	protein kinase binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(1)	16						CCCACTGTTCCCCCTGTGGTT	0.647000													16	44					0	0	0.003163	0	0
APC	324	broad.mit.edu	37	5	112177788	112177788	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:112177788G>A	ENST00000457016.1	+	16	6877	c.6497G>A	c.(6496-6498)cGa>cAa	p.R2166Q	APC_ENST00000508376.2_Missense_Mutation_p.R2166Q|APC_ENST00000257430.4_Missense_Mutation_p.R2166Q|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	2166	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AAAGGCCCACGAATTCTAAAA	0.348000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			10	44					0	0	0.008291	0	0
ZMYND19	116225	broad.mit.edu	37	9	140481550	140481550	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:140481550G>A	ENST00000298585.2	-	4	454	c.228C>T	c.(226-228)caC>caT	p.H76H	ZMYND19_ENST00000471957.1_5'UTR	NM_138462.2	NP_612471.1	Q96E35	ZMY19_HUMAN	zinc finger, MYND-type containing 19	76						Golgi apparatus|plasma membrane	zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	13	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)		CGCCCCCCCGGTGCCGCTCCC	0.632000													23	93					0	0	0.004656	0	0
NPTXR	23467	broad.mit.edu	37	22	39219206	39219206	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:39219206G>A	ENST00000333039.2	-	4	1283	c.1160C>T	c.(1159-1161)aCc>aTc	p.T387I		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	387	Pentaxin.					integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					ATCCCTTGTGGTCCAGGCGAT	0.647000													10	47					0	0	0.010729	0	0
GRB14	2888	broad.mit.edu	37	2	165476271	165476271	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:165476271C>T	ENST00000263915.3	-	2	788	c.250G>A	c.(250-252)Gag>Aag	p.E84K		NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	84					blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						CAGCATAGCTCAGGAAAAGGG	0.338000													15	56					0	0	0.004007	0	0
NONO	4841	broad.mit.edu	37	X	70511790	70511790	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:70511790C>T	ENST00000535149.1	+	2	692	c.49C>T	c.(49-51)Cat>Tat	p.H17Y	NONO_ENST00000276079.8_Missense_Mutation_p.H106Y|NONO_ENST00000373841.1_Missense_Mutation_p.H106Y|NONO_ENST00000373856.3_Missense_Mutation_p.H106Y	NM_001145410.1	NP_001138882.1	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	106					DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	19	Renal(35;0.156)					AGTCTTCATTCATAAGGATAA	0.438000			T	TFE3	papillary renal cancer								19	27					0	0	0.002780	0	0
OR52B4	143496	broad.mit.edu	37	11	4388791	4388791	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:4388791G>A	ENST00000408920.2	-	1	825	c.735C>T	c.(733-735)tcC>tcT	p.S245S		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCAGACATGGGAGCCAAATG	0.453000													15	63					0	0	0.003163	0	0
CXCR5	643	broad.mit.edu	37	11	118764404	118764404	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:118764404G>A	ENST00000292174.4	+	2	327	c.151G>A	c.(151-153)Gcc>Acc	p.A51T		NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	51					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		CTCCTTCAAGGCCGTGTTCGT	0.607000													20	121					0	0	0.010504	0	0
F5	2153	broad.mit.edu	37	1	169509710	169509710	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:169509710C>T	ENST00000367796.3	-	13	4834	c.4633G>A	c.(4633-4635)Gaa>Aaa	p.E1545K	F5_ENST00000367797.3_Missense_Mutation_p.E1540K			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1540	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TAATCAATTTCAGCATAGTCA	0.428000													9	32					0	0	0.004482	0	0
MYH11	4629	broad.mit.edu	37	16	15841531	15841531	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:15841531G>A	ENST00000338282.6	-	19	2413	c.2307C>T	c.(2305-2307)ttC>ttT	p.F769F	MYH11_ENST00000396324.3_Silent_p.F776F|MYH11_ENST00000300036.5_Silent_p.F769F|MYH11_ENST00000576790.1_Silent_p.F769F|MYH11_ENST00000452625.2_Silent_p.F776F	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	769	Actin-binding (By similarity).|Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CAGTTCGGAAGAAGATTTTGC	0.522000			T	CBFB	AML								8	52					0	0	0.003080	0	0
TCEA3	6920	broad.mit.edu	37	1	23743824	23743824	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:23743824C>T	ENST00000450454.2	-	4	404	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	TCEA3_ENST00000461794.1_Missense_Mutation_p.E63K|TCEA3_ENST00000374601.3_Missense_Mutation_p.E100K	NM_003196.1	NP_003187.1	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	100					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		AGccctttttccttcttcttt	0.473000													15	68					0	0	0.004990	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38196056	38196056	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:38196056G>A	ENST00000317025.8	-	3	1262	c.745C>T	c.(745-747)Cca>Tca	p.P249S	WHSC1L1_ENST00000316985.3_Missense_Mutation_p.P249S|WHSC1L1_ENST00000527502.1_Missense_Mutation_p.P249S|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.P249S	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	249					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			CAACTTACTGGGGCTTCCTCT	0.383000			T	NUP98	AML								16	68					0	0	0.004990	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146997332	146997332	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:146997332G>A	ENST00000361727.3	+	9	1964	c.1448G>A	c.(1447-1449)cGa>cAa	p.R483Q		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	483	Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCAGCAGTTCGAACTAATAGT	0.423000										HNSCC(39;0.1)			18	70					0	0	0.004990	0	0
ADAD1	132612	broad.mit.edu	37	4	123317448	123317448	+	Nonsense_Mutation	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:123317448A>T	ENST00000296513.2	+	7	825	c.640A>T	c.(640-642)Aaa>Taa	p.K214*	ADAD1_ENST00000388724.2_Nonsense_Mutation_p.K214*|ADAD1_ENST00000492454.1_3'UTR|ADAD1_ENST00000388725.2_Nonsense_Mutation_p.K196*	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	214					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						ACAGATCGTTAAAGAAAGATT	0.308000													7	23					0	0	0.003080	0	0
CSMD1	64478	broad.mit.edu	37	8	3263621	3263621	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:3263621C>T	ENST00000520002.1	-	16	2752	c.2197G>A	c.(2197-2199)Gga>Aga	p.G733R	CSMD1_ENST00000602723.1_Missense_Mutation_p.G733R|CSMD1_ENST00000400186.3_Missense_Mutation_p.G733R|CSMD1_ENST00000602557.1_Missense_Mutation_p.G733R|CSMD1_ENST00000542608.1_Missense_Mutation_p.G732R|CSMD1_ENST00000539096.1_Missense_Mutation_p.G732R|CSMD1_ENST00000537824.1_Missense_Mutation_p.G732R			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	733	Sushi 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GACTCGGATCCCTGGGTCTTG	0.562000													7	40					0	0	0.001984	0	0
BOD1L1	259282	broad.mit.edu	37	4	13604424	13604424	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:13604424G>A	ENST00000040738.5	-	10	4235	c.4100C>T	c.(4099-4101)cCa>cTa	p.P1367L		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1367							DNA binding										GTGAGCTTCTGGAATGTGTCT	0.413000													19	82					0	0	0.008871	0	0
PDZD2	23037	broad.mit.edu	37	5	32074338	32074338	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:32074338G>A	ENST00000438447.1	+	18	3514	c.3126G>A	c.(3124-3126)gaG>gaA	p.E1042E	PDZD2_ENST00000282493.3_Silent_p.E1042E			O15018	PDZD2_HUMAN	PDZ domain containing 2	1042					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						TGGACTTAGAGGAGAGTATCC	0.592000													26	83					0	0	0.003954	0	0
MAPK8	5599	broad.mit.edu	37	10	49618124	49618124	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:49618124G>A	ENST00000374189.1	+	5	544	c.363G>A	c.(361-363)atG>atA	p.M121I	MAPK8_ENST00000360332.3_Missense_Mutation_p.M121I|MAPK8_ENST00000395611.3_Missense_Mutation_p.M121I|MAPK8_ENST00000374182.3_Missense_Mutation_p.M121I|MAPK8_ENST00000374174.1_Missense_Mutation_p.M121I			P45983	MK08_HUMAN	mitogen-activated protein kinase 8	121	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	34		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		TGATTCAGATGGAGCTAGATC	0.398000													20	79					0	0	0.010504	0	0
PCNXL2	80003	broad.mit.edu	37	1	233190095	233190095	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:233190095C>T	ENST00000258229.8	-	25	4504	c.4270G>A	c.(4270-4272)Gat>Aat	p.D1424N	PCNXL2_ENST00000344698.2_Missense_Mutation_p.D76N	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1424						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TTGAGGTCATCTGAAGCCAAA	0.453000													4	28					0	0	0.009096	0	0
MUC16	94025	broad.mit.edu	37	19	9085376	9085376	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9085376G>A	ENST00000397910.4	-	1	6642	c.6439C>T	c.(6439-6441)Cca>Tca	p.P2147S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2147	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGGCCATTGGAAGAGGGACT	0.493000													17	56					0	0	0.006122	0	0
USP33	23032	broad.mit.edu	37	1	78180395	78180395	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:78180395G>A	ENST00000370793.1	-	20	2558	c.2212C>T	c.(2212-2214)Ctt>Ttt	p.L738F	USP33_ENST00000370792.3_Missense_Mutation_p.L730F|USP33_ENST00000357428.1_Missense_Mutation_p.L738F|USP33_ENST00000370794.3_Missense_Mutation_p.L707F	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	738	DUSP 1.				axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						TAAAACTGAAGGAGGCTTGGT	0.353000													18	50					0	0	0.006122	0	0
LILRA1	11024	broad.mit.edu	37	19	55106623	55106623	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:55106623G>A	ENST00000453777.1	+	5	587	c.417G>A	c.(415-417)ggG>ggA	p.G139G	LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000251372.3_Silent_p.G139G|LILRB1_ENST00000448689.1_Intron	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	139	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		CCTCAGGAGGGAACGTGACCC	0.542000													22	106					0	0	0.012319	0	0
SLC26A6	65010	broad.mit.edu	37	3	48664104	48664104	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:48664104G>A	ENST00000358747.6	-	18	2275	c.2025C>T	c.(2023-2025)ttC>ttT	p.F675F	SLC26A6_ENST00000455886.2_Silent_p.F660F|SLC26A6_ENST00000420764.2_Silent_p.F695F|SLC26A6_ENST00000337000.8_Silent_p.F588F|SLC26A6_ENST00000383733.3_Silent_p.F677F|SLC26A6_ENST00000395550.2_Silent_p.F696F	NM_001040454.1	NP_001035544.1			solute carrier family 26 (anion exchanger), member 6										SLC26A6/PRKAR2A(2)	NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		CAATCTCCCGGAAGTCATGGA	0.597000													34	147					0	0	0.006230	0	0
CSMD2	114784	broad.mit.edu	37	1	34080129	34080129	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:34080129C>T	ENST00000373381.4	-	40	6284	c.6108G>A	c.(6106-6108)tgG>tgA	p.W2036*	CSMD2_ENST00000373380.1_Nonsense_Mutation_p.W909*|CSMD2_ENST00000373388.2_Nonsense_Mutation_p.W135*|CSMD2_ENST00000373377.1_Nonsense_Mutation_p.W135*	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1996	CUB 12.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGCTATTTTCCAGGAGCAGT	0.567000													5	34					0	0	0.000602	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338222	13338222	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:13338222C>T	ENST00000602906.1	+	0	240																				kidney(3)|lung(1)	4						AGGAGATTTTCCTTTGGGAGT	0.433000													7	32					0	0	0.003080	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657494	72657494	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:72657494C>T	ENST00000425256.1	-	0	2417					NR_002164.1																						ttctggtattcccaccttgtc	0.507000													66	148					0	0	0.014410	0	0
ADCK4	79934	broad.mit.edu	37	19	41211268	41211268	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:41211268C>T	ENST00000324464.3	-	6	753	c.452G>A	c.(451-453)gGg>gAg	p.G151E	ADCK4_ENST00000243583.6_Intron|ADCK4_ENST00000450541.1_Intron	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	151						integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GAGGGCGGCCCCTCGAACTGT	0.612000													11	49					0	0	0.008291	0	0
PTPN3	5774	broad.mit.edu	37	9	112144596	112144596	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:112144596G>A	ENST00000412145.1	-	19	4674	c.2121C>T	c.(2119-2121)gtC>gtT	p.V707V	PTPN3_ENST00000374541.2_Silent_p.V838V|PTPN3_ENST00000394827.3_Silent_p.V306V|PTPN3_ENST00000262539.3_Silent_p.V684V|PTPN3_ENST00000446349.1_Silent_p.V662V	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	838	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						AGTGAACTAGGACGGGCTCGC	0.547000													5	17					0	0	0.000602	0	0
MUC16	94025	broad.mit.edu	37	19	9046738	9046738	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9046738C>T	ENST00000397910.4	-	5	35096	c.34893G>A	c.(34891-34893)gtG>gtA	p.V11631V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11633	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.V11631V(1)|p.V7264V(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCTGTGAGGTCACTACCCCTG	0.527000													11	75					0	0	0.008291	0	0
FSHR	2492	broad.mit.edu	37	2	49217768	49217768	+	Missense_Mutation	SNP	G	G	A	rs121909665		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:49217768G>A	ENST00000406846.2	-	5	502	c.383C>T	c.(382-384)tCc>tTc	p.S128F	FSHR_ENST00000469138.1_5'UTR|FSHR_ENST00000304421.4_Missense_Mutation_p.S128F|FSHR_ENST00000346173.3_Missense_Mutation_p.S128F|FSHR_ENST00000541117.1_5'UTR	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	128			S -> Y (in OHSS; displays increase in affinity and sensitivity toward hCG and does not show any constitutive activity nor promiscuous activation by TSH).		female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	ACCTGTGTTGGATATTAACCT	0.333000									Gonadal Dysgenesis, 46 XX				9	49					0	0	0.010729	0	0
C2orf16	84226	broad.mit.edu	37	2	27801985	27801985	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:27801985G>A	ENST00000408964.2	+	1	2597	c.2546G>A	c.(2545-2547)cGa>cAa	p.R849Q		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	849								p.R849Q(2)		breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					TGGAGATCACGATCTAGGACA	0.478000													11	50					0	0	0.008291	0	0
CSMD2	114784	broad.mit.edu	37	1	33990616	33990616	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:33990616G>A	ENST00000373381.4	-	66	10438	c.10262C>T	c.(10261-10263)tCc>tTc	p.S3421F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3277						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTTCCACAGGGAATTCTTGGC	0.502000													32	137					0	0	0.005524	0	0
VAMP4	8674	broad.mit.edu	37	1	171679897	171679897	+	Silent	SNP	T	T	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:171679897T>G	ENST00000236192.7	-	5	608	c.222A>C	c.(220-222)gtA>gtC	p.V74V	VAMP4_ENST00000415773.1_Silent_p.V73V|VAMP4_ENST00000367740.2_Silent_p.V73V|VAMP4_ENST00000482519.1_Intron	NM_001185127.1|NM_003762.4	NP_001172056.1|NP_003753.2	O75379	VAMP4_HUMAN	vesicle-associated membrane protein 4	74	v-SNARE coiled-coil homology.				vesicle-mediated transport	endosome|Golgi membrane|integral to membrane|lysosome				large_intestine(4)	4	all_cancers(6;1.42e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CTCTCTCAATTACCTTTGTAA	0.318000													11	85					0	0	0.008291	0	0
SMTNL2	342527	broad.mit.edu	37	17	4498512	4498512	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:4498512G>A	ENST00000389313.4	+	5	946	c.879G>A	c.(877-879)caG>caA	p.Q293Q	SMTNL2_ENST00000338859.4_Silent_p.Q149Q	NM_001114974.1	NP_001108446.1	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2	293										breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		TCCATCGGCAGGGGGAGCGTC	0.667000													21	39					0	0	0.003330	0	0
PHF3	23469	broad.mit.edu	37	6	64394342	64394342	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:64394342G>T	ENST00000262043.3	+	4	1059	c.719G>T	c.(718-720)tGt>tTt	p.C240F	PHF3_ENST00000393387.1_Missense_Mutation_p.C240F|PHF3_ENST00000509330.1_Missense_Mutation_p.C240F			Q92576	PHF3_HUMAN	PHD finger protein 3	240					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding	p.C240Y(1)		breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AAGCATAAGTGTAATAATCCG	0.348000													18	85					2.35188e-11	2.45373e-11	0.006122	1	0
ASTN2	23245	broad.mit.edu	37	9	119770528	119770528	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:119770528G>A	ENST00000313400.4	-	7	1534	c.1434C>T	c.(1432-1434)ttC>ttT	p.F478F	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Silent_p.F478F|ASTN2_ENST00000361209.2_Silent_p.F427F			O75129	ASTN2_HUMAN	astrotactin 2	478						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CACTCACCACGAAGCTGCTTC	0.502000													8	47					0	0	0.006214	0	0
TYW1	55253	broad.mit.edu	37	7	66489949	66489949	+	Silent	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:66489949A>G	ENST00000359626.5	+	7	1088	c.924A>G	c.(922-924)ctA>ctG	p.L308L		NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	308					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				ATCAGAGCCTAAATTCCATTG	0.428000													20	77					0	0	0.014323	0	0
ABCC9	10060	broad.mit.edu	37	12	21968825	21968825	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:21968825G>A	ENST00000261200.4	-	32	3894	c.3895C>T	c.(3895-3897)Cct>Tct	p.P1299S	ABCC9_ENST00000345162.2_Missense_Mutation_p.P1263S|ABCC9_ENST00000261201.4_Missense_Mutation_p.P1299S	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1299					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACTTGAGAAGGATCTGGAGGA	0.353000													11	34					0	0	0.013537	0	0
THSD7B	80731	broad.mit.edu	37	2	138373870	138373870	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:138373870C>T	ENST00000409968.1	+	18	3727	c.3549C>T	c.(3547-3549)ttC>ttT	p.F1183F	THSD7B_ENST00000272643.3_Silent_p.F1186F|THSD7B_ENST00000413152.2_Silent_p.F1155F|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCTTCCAGTTCCAGTACAATC	0.433000													22	121					0	0	0.002780	0	0
CTCFL	140690	broad.mit.edu	37	20	56098238	56098238	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:56098238C>T	ENST00000426658.2	-	2	1301	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K	CTCFL_ENST00000422869.2_Missense_Mutation_p.E214K|CTCFL_ENST00000371196.2_Missense_Mutation_p.E214K|CTCFL_ENST00000422109.2_Missense_Mutation_p.E214K|CTCFL_ENST00000433949.2_Missense_Mutation_p.E214K|CTCFL_ENST00000243914.3_Missense_Mutation_p.E214K|CTCFL_ENST00000539382.1_Missense_Mutation_p.E9K|CTCFL_ENST00000423479.2_Missense_Mutation_p.E214K|CTCFL_ENST00000502686.2_Intron|CTCFL_ENST00000429804.2_Missense_Mutation_p.E214K|CTCFL_ENST00000432255.2_Missense_Mutation_p.E214K			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	214					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			AGAACAATTTCGTCACTTCTT	0.403000													22	111					0	0	0.014323	0	0
ZNF761	388561	broad.mit.edu	37	19	53959500	53959500	+	RNA	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:53959500G>A	ENST00000454407.1	+	0	2192							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.C526F(1)		endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		CCTTACAAATGTGAAGATAGT	0.388000													16	36					0	0	0.003163	0	0
MCM8	84515	broad.mit.edu	37	20	5963670	5963670	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:5963670T>G	ENST00000378896.3	+	14	1969	c.1592T>G	c.(1591-1593)tTg>tGg	p.L531W	MCM8_ENST00000265187.4_Missense_Mutation_p.L515W|MCM8_ENST00000378886.2_Missense_Mutation_p.L571W|MCM8_ENST00000378883.1_Missense_Mutation_p.L484W	NM_032485.4|NM_182802.1	NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	531	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						CAAGCCTTGTTGGAAGCCATG	0.398000													7	46					0	0	0.004482	0	0
BRAT1	221927	broad.mit.edu	37	7	2584620	2584620	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:2584620G>A	ENST00000340611.4	-	4	609	c.353C>T	c.(352-354)aCc>aTc	p.T118I		NM_152743.3	NP_689956.2	Q6PJG6	BRAT1_HUMAN	BRCA1-associated ATM activator 1	118					response to ionizing radiation	nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						GCTGCGCACGGTGGGGACGGC	0.687000													5	10					0	0	0.000602	0	0
LRP1	4035	broad.mit.edu	37	12	57570871	57570871	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:57570871G>A	ENST00000243077.3	+	25	4505	c.4039G>A	c.(4039-4041)Gag>Aag	p.E1347K		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1347					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity	p.E1347K(1)		NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGCCACACCCGAGGGCCTGGC	0.582000													25	103					0	0	0.003954	0	0
PRDM1	639	broad.mit.edu	37	6	106554840	106554840	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:106554840C>T	ENST00000369096.4	+	7	2191	c.1957C>T	c.(1957-1959)Cat>Tat	p.H653Y	PRDM1_ENST00000369089.3_Missense_Mutation_p.H519Y|PRDM1_ENST00000369091.2_Missense_Mutation_p.H617Y	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	653					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		CCTGCGACTCCATTCTGGAGA	0.562000			"""D, N, Mis, F, S"""		DLBCL								18	83					0	0	0.007413	0	0
TNRC6B	23112	broad.mit.edu	37	22	40662517	40662517	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:40662517G>A	ENST00000454349.2	+	5	2494	c.2283G>A	c.(2281-2283)tgG>tgA	p.W761*	TNRC6B_ENST00000335727.8_Nonsense_Mutation_p.W761*|TNRC6B_ENST00000301923.9_Intron|TNRC6B_ENST00000402203.1_Intron	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	761					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						ACAGCAATTGGGAAAGTTCTG	0.517000													3	28					0	0	0.004672	0	0
FAT4	79633	broad.mit.edu	37	4	126371291	126371291	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:126371291G>A	ENST00000394329.3	+	9	9133	c.9120G>A	c.(9118-9120)tgG>tgA	p.W3040*	FAT4_ENST00000335110.5_Nonsense_Mutation_p.W1338*	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3040	Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATACGGGGTGGATTTCAGTAG	0.373000													7	37					0	0	0.003080	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276910	71276910	+	Missense_Mutation	SNP	G	G	A	rs36179995		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:71276910G>A	ENST00000398531.1	+	1	302	c.277G>A	c.(277-279)Ggc>Agc	p.G93S	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	93	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						CTCCAAGGGGGGCTGTGGCTC	0.677000													45	147					0	0	0.013114	0	0
SCN9A	6335	broad.mit.edu	37	2	167060535	167060535	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:167060535G>A	ENST00000375387.4	-	26	5047	c.4707C>T	c.(4705-4707)tcC>tcT	p.S1569S	SCN9A_ENST00000409435.1_Silent_p.S1568S|SCN9A_ENST00000409672.1_Silent_p.S1557S|AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000303354.6_Silent_p.S1569S			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1568						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AGTGTCTGAGGGAGATCAGTT	0.313000													10	18					0	0	0.008291	0	0
OR4A15	81328	broad.mit.edu	37	11	55136058	55136058	+	Silent	SNP	G	G	A	rs141225150	byFrequency	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:55136058G>A	ENST00000314706.3	+	1	699	c.699G>A	c.(697-699)gcG>gcA	p.A233A		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A233A(1)		NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						ATGGAGGAGCGATTTGTGCTG	0.413000													11	66					0	0	0.010729	0	0
ABCB11	8647	broad.mit.edu	37	2	169791708	169791708	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:169791708G>A	ENST00000263817.6	-	23	3166	c.3042C>T	c.(3040-3042)ttC>ttT	p.F1014F		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1014	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	ACACATAGCTGAAATGGAGCC	0.438000													23	97					0	0	0.002780	0	0
SOGA3	387104	broad.mit.edu	37	6	127797362	127797362	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:127797362C>T	ENST00000556132.1	-	6	2673	c.1809G>A	c.(1807-1809)agG>agA	p.R603R	SOGA3_ENST00000465909.2_Silent_p.R603R|SOGA3_ENST00000525778.1_Silent_p.R603R|SOGA3_ENST00000481848.2_Silent_p.R603R|SOGA3_ENST00000368268.2_Silent_p.R603R	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	603						integral to membrane											CGACGATTTTCCTGCCCAGGA	0.607000													37	191					0	0	0.010771	0	0
COL22A1	169044	broad.mit.edu	37	8	139833595	139833595	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:139833595C>T	ENST00000303045.6	-	7	1475	c.1029G>A	c.(1027-1029)atG>atA	p.M343I	COL22A1_ENST00000435777.1_Missense_Mutation_p.M343I	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	343	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CAGCATCTTTCATGGCACCCA	0.572000										HNSCC(7;0.00092)			24	132					0	0	0.004656	0	0
BCKDHA	593	broad.mit.edu	37	19	41916585	41916585	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:41916585A>T	ENST00000269980.2	+	2	520	c.152A>T	c.(151-153)aAg>aTg	p.K51M	BCKDHA_ENST00000457836.2_Missense_Mutation_p.K29M|CTC-435M10.3_ENST00000540732.1_Missense_Mutation_p.K85M|BCKDHA_ENST00000595085.1_Missense_Mutation_p.K85M	NM_000709.3|NM_001164783.1	NP_000700.1|NP_001158255.1	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha polypeptide	51					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	10						CTGGATGACAAGCCCCAGTTC	0.577000													13	64					0	0	0.002450	0	0
OR51F1	256892	broad.mit.edu	37	11	4790947	4790947	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:4790947C>T	ENST00000380383.1	-	1	221	c.222G>A	c.(220-222)agG>agA	p.R74R	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron|OR51F1_ENST00000343430.3_Silent_p.R67R			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	67						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		TGGCTGATAGCCTGAAGAGGA	0.443000													13	27					0	0	0.001855	0	0
PCDH18	54510	broad.mit.edu	37	4	138451643	138451643	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:138451643C>T	ENST00000344876.4	-	1	1986	c.1600G>A	c.(1600-1602)Gat>Aat	p.D534N	PCDH18_ENST00000412923.2_Missense_Mutation_p.D534N|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000507846.1_Missense_Mutation_p.D314N	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	534	Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TCTTCATGATCAAAGATTCTG	0.423000													12	87					0	0	0.002450	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54930880	54930880	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:54930880C>T	ENST00000474759.1	+	26	2399	c.2351C>T	c.(2350-2352)tCg>tTg	p.S784L	CACNA2D3_ENST00000288197.5_Missense_Mutation_p.S784L|CACNA2D3-AS1_ENST00000471265.1_RNA|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.S690L|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.S784L	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	784						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTCGTCTACTCGATCCCATTC	0.567000													11	97					0	0	0.001855	0	0
SPATA16	83893	broad.mit.edu	37	3	172634193	172634193	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:172634193C>T	ENST00000351008.3	-	9	1600	c.1417G>A	c.(1417-1419)Gag>Aag	p.E473K		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	473					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TGGGACTGCTCCTTTACTCTC	0.463000													30	126					0	0	0.012213	0	0
FAAH2	158584	broad.mit.edu	37	X	57515352	57515352	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:57515352C>T	ENST00000374900.4	+	11	1706	c.1586C>T	c.(1585-1587)cCa>cTa	p.P529L	FAAH2_ENST00000491179.1_3'UTR	NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	529						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						TGGGTCTGTCCAGGAAAGTTT	0.488000										HNSCC(52;0.14)			12	21					0	0	0.013537	0	0
HIVEP2	3097	broad.mit.edu	37	6	143089611	143089611	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:143089611G>A	ENST00000367603.2	-	6	5992	c.5250C>T	c.(5248-5250)atC>atT	p.I1750I	HIVEP2_ENST00000012134.2_Silent_p.I1750I|HIVEP2_ENST00000367604.1_Silent_p.I1750I	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1750					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TTTCCTTTAAGATATTTCCCA	0.363000													12	86					0	0	0.013537	0	0
PRKAA2	5563	broad.mit.edu	37	1	57169911	57169911	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:57169911G>A	ENST00000371244.4	+	7	1122	c.1056G>A	c.(1054-1056)atG>atA	p.M352I		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	352					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						GTTCTTTTATGGATGATAGTG	0.468000													10	42					0	0	0.008291	0	0
TTN	7273	broad.mit.edu	37	2	179569654	179569654	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:179569654C>T	ENST00000589042.1	-	104	29868	c.29644G>A	c.(29644-29646)Gaa>Aaa	p.E9882K	TTN_ENST00000342992.6_Missense_Mutation_p.E8638K|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E9565K|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9565	Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTCAAATTCCTTTTCGTCC	0.323000													18	113					0	0	0.014323	0	0
OR10S1	219873	broad.mit.edu	37	11	123847965	123847965	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:123847965T>G	ENST00000531945.1	-	1	523	c.434A>C	c.(433-435)cAc>cCc	p.H145P		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CACTGGGTAGTGCAGGGGTTG	0.547000													8	41					0	0	0.003080	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68964644	68964644	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:68964644C>T	ENST00000356291.2	-	2	183	c.124G>A	c.(124-126)Gga>Aga	p.G42R		NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	42					proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						ATTGCAATTCCTATGATTGCT	0.383000													11	37					0	0	0.010729	0	0
PPP1R36	145376	broad.mit.edu	37	14	65019549	65019549	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:65019549C>T	ENST00000298705.1	+	3	248	c.152C>T	c.(151-153)tCt>tTt	p.S51F	RP11-973N13.3_ENST00000554454.1_RNA|RP11-973N13.3_ENST00000556634.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	51																	GCAGAAGATTCTGTCCAGTGG	0.388000													19	33					0	0	0.010504	0	0
RTTN	25914	broad.mit.edu	37	18	67742728	67742728	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:67742728G>A	ENST00000255674.6	-	33	4710	c.4424C>T	c.(4423-4425)cCt>cTt	p.P1475L	RTTN_ENST00000437017.1_Missense_Mutation_p.P1475L|RTTN_ENST00000454359.1_3'UTR	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	1475							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				CTGAAGGGCAGGTTTTCCAAT	0.408000													18	67					0	0	0.008871	0	0
NUAK2	81788	broad.mit.edu	37	1	205273440	205273440	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:205273440G>A	ENST00000367157.3	-	7	1151	c.1025C>T	c.(1024-1026)cCc>cTc	p.P342L		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	342					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CTCCAGGAGGGGGCGGGAGGA	0.672000													8	25					0	0	0.006214	0	0
NUP214	8021	broad.mit.edu	37	9	134072836	134072836	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:134072836G>A	ENST00000359428.5	+	29	4099	c.3955G>A	c.(3955-3957)Gag>Aag	p.E1319K	NUP214_ENST00000465486.2_3'UTR|NUP214_ENST00000483497.2_Missense_Mutation_p.E145K|NUP214_ENST00000411637.2_Missense_Mutation_p.E1309K|NUP214_ENST00000451030.1_Missense_Mutation_p.E1320K			P35658	NU214_HUMAN	nucleoporin 214kDa	1319	11 X 5 AA approximate repeats.|Pro/Ser/Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		CAAGCTGGGAGAGCTTCTGTT	0.522000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								16	110					0	0	0.006122	0	0
NLRP8	126205	broad.mit.edu	37	19	56466522	56466522	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:56466522C>T	ENST00000291971.3	+	3	1169	c.1098C>T	c.(1096-1098)ttC>ttT	p.F366F	NLRP8_ENST00000590542.1_Silent_p.F366F	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	366	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TCAAGTATTTCCAGATGTATT	0.463000													10	76					0	0	0.008291	0	0
SHROOM3	57619	broad.mit.edu	37	4	77699981	77699981	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:77699981G>A	ENST00000296043.6	+	11	6595	c.5642G>A	c.(5641-5643)aGg>aAg	p.R1881K	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1881	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TACGAGAAAAGGAAGATCCTG	0.537000													9	41					0	0	0.006214	0	0
CYP2C19	1557	broad.mit.edu	37	10	96540261	96540261	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:96540261C>T	ENST00000371321.3	+	4	569	c.487C>T	c.(487-489)Ccc>Tcc	p.P163S	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	163					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TTTAGCTTCACCCTGTGATCC	0.313000													19	99					0	0	0.012319	0	0
NEK11	79858	broad.mit.edu	37	3	130947510	130947510	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:130947510C>T	ENST00000383366.4	+	15	1831	c.1538C>T	c.(1537-1539)cCt>cTt	p.P513L	NEK11_ENST00000429253.2_Missense_Mutation_p.P513L|NEK11_ENST00000508196.1_Missense_Mutation_p.P513L|NEK11_ENST00000510688.1_Missense_Mutation_p.P513L|NEK11_ENST00000510769.1_Missense_Mutation_p.P408L|NEK11_ENST00000412440.2_Missense_Mutation_p.P329L	NM_024800.4	NP_079076.3	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11	513					cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|stomach(1)|urinary_tract(2)	33						GGATCCCAGCCTGCTTACAGA	0.448000													9	43					0	0	0.006214	0	0
C14orf166B	145497	broad.mit.edu	37	14	77327179	77327179	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:77327179C>T	ENST00000393774.3	+	11	1372	c.1248C>T	c.(1246-1248)atC>atT	p.I416I		NM_194287.2	NP_919263.2	Q0VAA2	CN16B_HUMAN	chromosome 14 open reading frame 166B	416										breast(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(1)	18			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		TGAAACTGATCCAGGTGAGCT	0.552000													8	50					0	0	0.006214	0	0
ZNF347	84671	broad.mit.edu	37	19	53644315	53644315	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:53644315C>T	ENST00000452676.2	-	5	2195	c.1769G>A	c.(1768-1770)gGa>gAa	p.G590E	ZNF347_ENST00000601469.2_Missense_Mutation_p.G590E|ZNF347_ENST00000334197.7_Missense_Mutation_p.G589E|ZNF347_ENST00000601804.1_Intron	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	589					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		AGTATGAATTCCCCGATGTCT	0.408000													12	74					0	0	0.001855	0	0
FLRT3	23767	broad.mit.edu	37	20	14306665	14306665	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:14306665A>C	ENST00000378053.3	-	2	1744	c.1488T>G	c.(1486-1488)tgT>tgG	p.C496W	FLRT3_ENST00000341420.4_Missense_Mutation_p.C496W|MACROD2_ENST00000217246.4_Intron|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	496	Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		CAGTCTCAATACAAACAGGAG	0.448000													5	131					0	0	0.000602	0	0
MATR3	9782	broad.mit.edu	37	5	138643519	138643519	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:138643519C>T	ENST00000394800.2	+	6	964	c.415C>T	c.(415-417)Ccc>Tcc	p.P139S	MATR3_ENST00000510056.1_Missense_Mutation_p.P139S|MATR3_ENST00000509990.1_Missense_Mutation_p.P139S|MATR3_ENST00000361059.2_Missense_Mutation_p.P139S|MATR3_ENST00000502929.1_Missense_Mutation_p.P139S|MATR3_ENST00000502499.1_Intron|MATR3_ENST00000394805.3_Missense_Mutation_p.P139S|MATR3_ENST00000504203.1_Intron|MATR3_ENST00000503811.1_Intron			P43243	MATR3_HUMAN	matrin 3	139						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGAGAATTTGCCCCAAATCCT	0.473000													7	32					0	0	0.001984	0	0
AP1G2	8906	broad.mit.edu	37	14	24030569	24030569	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:24030569C>T	ENST00000308724.5	-	18	2684	c.1929G>A	c.(1927-1929)ctG>ctA	p.L643L	RP11-66N24.3_ENST00000555968.1_RNA|AP1G2_ENST00000397120.3_Silent_p.L643L	NM_003917.2	NP_003908.1	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2 subunit	643					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	28	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		GGGAGGGGTCCAGATGGGGAG	0.597000													15	62					0	0	0.004990	0	0
EGFR	1956	broad.mit.edu	37	7	55220311	55220311	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:55220311A>G	ENST00000275493.2	+	6	878	c.701A>G	c.(700-702)aAc>aGc	p.N234S	EGFR_ENST00000455089.1_Missense_Mutation_p.N189S|EGFR_ENST00000454757.2_Missense_Mutation_p.N181S|EGFR_ENST00000344576.2_Missense_Mutation_p.N234S|EGFR_ENST00000442591.1_Missense_Mutation_p.N234S|EGFR_ENST00000420316.2_Missense_Mutation_p.N234S|EGFR_ENST00000342916.3_Missense_Mutation_p.N234S	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	234					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGCTGCCACAACCAGTGTGCT	0.647000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			20	124					0	0	0.007413	0	0
KIAA1377	57562	broad.mit.edu	37	11	101834560	101834560	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:101834560C>T	ENST00000263468.8	+	6	3064	c.2794C>T	c.(2794-2796)Ccc>Tcc	p.P932S	KIAA1377_ENST00000537689.1_Missense_Mutation_p.P733S	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	932							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AGAATCAGTTCCCTTATGGAA	0.378000													17	78					0	0	0.007413	0	0
NR6A1	2649	broad.mit.edu	37	9	127289093	127289093	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:127289093T>C	ENST00000487099.2	-	8	1323	c.1166A>G	c.(1165-1167)tAt>tGt	p.Y389C	NR6A1_ENST00000344523.4_Missense_Mutation_p.Y388C|NR6A1_ENST00000373584.3_Missense_Mutation_p.Y385C|NR6A1_ENST00000416460.2_Missense_Mutation_p.Y384C	NM_001278546.1	NP_001265475.1	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	389					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.Y389C(1)		NS(1)|breast(1)|cervix(1)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	17						CATGCAAGCATACTCCTCGTT	0.498000													26	92					0	0	0.004656	0	0
FOXRED2	80020	broad.mit.edu	37	22	36892167	36892167	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:36892167C>T	ENST00000397224.4	-	7	1564	c.1471G>A	c.(1471-1473)Ggg>Agg	p.G491R	FOXRED2_ENST00000216187.6_Missense_Mutation_p.G491R|FOXRED2_ENST00000366463.3_Missense_Mutation_p.G43R|FOXRED2_ENST00000397223.4_Missense_Mutation_p.G491R	NM_001102371.1	NP_001095841.1	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	491					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						ACGAAGAGCCCGTGCTTTGCC	0.547000													13	109					0	0	0.002450	0	0
OR2B11	127623	broad.mit.edu	37	1	247614409	247614409	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:247614409G>A	ENST00000318749.6	-	1	899	c.876C>T	c.(874-876)ttC>ttT	p.F292F		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GGGTGTAGGTGAAGGGATTGA	0.483000													29	178					0	0	0.013726	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802120	185802120	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:185802120C>T	ENST00000302277.6	+	4	2591	c.1997C>T	c.(1996-1998)tCc>tTc	p.S666F		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	666						intracellular	zinc ion binding	p.S666Y(1)		NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GAATCCATATCCTTAAGTGAC	0.318000													9	59					0	0	0.006214	0	0
SLC38A9	153129	broad.mit.edu	37	5	54948435	54948435	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:54948435G>A	ENST00000539768.1	-	8	873	c.874C>T	c.(874-876)Ccc>Tcc	p.P292S	SLC38A9_ENST00000515629.1_Missense_Mutation_p.P229S|SLC38A9_ENST00000512595.1_Missense_Mutation_p.P265S|SLC38A9_ENST00000396865.2_Missense_Mutation_p.P292S|SLC38A9_ENST00000416547.2_Missense_Mutation_p.P168S|SLC38A9_ENST00000318672.3_Missense_Mutation_p.P292S			Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	292					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				AGATAAAAGGGGACTGTCCTG	0.433000													8	36					0	0	0.004482	0	0
FAT4	79633	broad.mit.edu	37	4	126242301	126242301	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:126242301C>T	ENST00000394329.3	+	1	4748	c.4735C>T	c.(4735-4737)Cgt>Tgt	p.R1579C		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1579	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CATTGTTGATCGTTATAGTGG	0.458000													22	118					0	0	0.014323	0	0
EPPK1	83481	broad.mit.edu	37	8	144941969	144941969	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:144941969C>T	ENST00000525985.1	-	2	5524	c.5453G>A	c.(5452-5454)gGa>gAa	p.G1818E				P58107	EPIPL_HUMAN	epiplakin 1	1818						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACTCTGGGCTCCATACTCCTG	0.547000													45	141					0	0	0.010771	0	0
MROH8	140699	broad.mit.edu	37	20	35738679	35738679	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:35738679C>T	ENST00000400441.3	-	22	2893	c.2894G>A	c.(2893-2895)aGa>aAa	p.R965K	MROH8_ENST00000441008.2_3'UTR|MROH8_ENST00000217333.8_Missense_Mutation_p.R794K					maestro heat-like repeat family member 8																		GACTGCTGATCTTCTGATGGG	0.378000													54	121					0	0	0.014410	0	0
SCN9A	6335	broad.mit.edu	37	2	167141319	167141319	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:167141319G>A	ENST00000375387.4	-	12	1961	c.1621C>T	c.(1621-1623)Cgt>Tgt	p.R541C	SCN9A_ENST00000409435.1_Missense_Mutation_p.R540C|SCN9A_ENST00000409672.1_Missense_Mutation_p.R540C|AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000303354.6_Missense_Mutation_p.R541C			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	540						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AAGGAGCCACGAATGCTGAGT	0.423000													7	16					0	0	0.004482	0	0
PSMD3	5709	broad.mit.edu	37	17	38151308	38151308	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:38151308C>T	ENST00000264639.4	+	7	1257	c.1083C>T	c.(1081-1083)ttC>ttT	p.F361F	PSMD3_ENST00000541736.1_Silent_p.F223F	NM_002809.3	NP_002800.2	O43242	PSMD3_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	361	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Colorectal(19;0.000442)					TGCCCTATTTCCTTCTGACTC	0.587000													32	134					0	0	0.009535	0	0
OVGP1	5016	broad.mit.edu	37	1	111969247	111969247	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:111969247G>A	ENST00000369732.3	-	3	127	c.72C>T	c.(70-72)ctC>ctT	p.L24L	OVGP1_ENST00000540696.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	24					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity	p.L66L(1)|p.L24L(1)		NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		AATAACACACGAGTTTATGGG	0.547000													3	19					0	0	0.004672	0	0
MCTP2	55784	broad.mit.edu	37	15	95013586	95013586	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:95013586C>T	ENST00000357742.4	+	20	2385	c.2385C>T	c.(2383-2385)ttC>ttT	p.F795F	MCTP2_ENST00000451018.3_Silent_p.F740F	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	795					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CGGTCCCCTTCCTTTCATCTC	0.408000													16	89					0	0	0.004990	0	0
SLC13A1	6561	broad.mit.edu	37	7	122757627	122757627	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:122757627C>T	ENST00000194130.2	-	14	1587	c.1548G>A	c.(1546-1548)ctG>ctA	p.L516L	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	516						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TAGAAGGTATCAGAATATAAA	0.363000													4	39					0	0	0.009096	0	0
AKAP6	9472	broad.mit.edu	37	14	33293746	33293746	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:33293746G>A	ENST00000280979.4	+	13	6897	c.6727G>A	c.(6727-6729)Gag>Aag	p.E2243K	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	2243					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AGAAAACTTAGAGTTTACTCC	0.443000													12	30					0	0	0.002450	0	0
RGS18	64407	broad.mit.edu	37	1	192128357	192128357	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:192128357G>A	ENST00000367460.3	+	2	308	c.127G>A	c.(127-129)Gaa>Aaa	p.E43K	RGS18_ENST00000481707.1_3'UTR	NM_130782.2	NP_570138.1	Q9NS28	RGS18_HUMAN	regulator of G-protein signaling 18	43					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			kidney(1)|large_intestine(2)|lung(15)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CAGAGCTAAGGAAAAAAGAAA	0.393000													8	20					0	0	0.004482	0	0
DENND1A	57706	broad.mit.edu	37	9	126319965	126319965	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:126319965G>A	ENST00000373624.2	-	13	1078	c.877C>T	c.(877-879)Ctg>Ttg	p.L293L	DENND1A_ENST00000373618.1_Silent_p.L261L|DENND1A_ENST00000373620.3_Silent_p.L293L|DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000542603.1_Intron|DENND1A_ENST00000394215.2_Silent_p.L263L|DENND1A_ENST00000394219.3_Silent_p.L261L	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	293						cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						CTGTTCTTCAGGGAAGAGATC	0.537000													7	22					0	0	0.003080	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204423835	204423835	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:204423835G>A	ENST00000367187.3	-	13	2584	c.2028C>T	c.(2026-2028)ttC>ttT	p.F676F	PIK3C2B_ENST00000496872.1_5'UTR|PIK3C2B_ENST00000424712.2_Silent_p.F676F	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	676					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GGTACTTGGAGAAGTGAGCTC	0.557000													22	161					0	0	0.014323	0	0
STXBP5L	9515	broad.mit.edu	37	3	120957827	120957827	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:120957827C>T	ENST00000273666.6	+	13	1465	c.1194C>T	c.(1192-1194)atC>atT	p.I398I	STXBP5L_ENST00000497029.1_Silent_p.I398I|STXBP5L_ENST00000492541.1_Silent_p.I398I|STXBP5L_ENST00000472879.1_Silent_p.I398I|STXBP5L_ENST00000471454.1_Silent_p.I398I	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	398					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		GTTTTCCAATCTTTGAAAATC	0.308000													4	24					0	0	0.009096	0	0
SLIT3	6586	broad.mit.edu	37	5	168199885	168199885	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:168199885C>T	ENST00000519560.1	-	14	1779	c.1360G>A	c.(1360-1362)Gac>Aac	p.D454N	SLIT3_ENST00000332966.8_Missense_Mutation_p.D454N|SLIT3_ENST00000404867.3_Missense_Mutation_p.D454N	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	454	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATGGGGTTGTCCTGGAGGTAG	0.612000													13	45					0	0	0.002450	0	0
COL28A1	340267	broad.mit.edu	37	7	7571399	7571399	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:7571399C>T	ENST00000399429.3	-	3	401	c.261G>A	c.(259-261)ttG>ttA	p.L87L		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	87	VWFA 1.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TGTCATATTCCAAGGAGCGAC	0.423000													31	56					0	0	0.012213	0	0
CSTF2T	23283	broad.mit.edu	37	10	53458193	53458193	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:53458193G>A	ENST00000331173.4	-	1	1162	c.1117C>T	c.(1117-1119)Cgt>Tgt	p.R373C	PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373980.4_Intron|PRKG1_ENST00000373985.1_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	373	Gly-rich.				mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GAAGGGCCACGAGTGTCATGA	0.562000													19	90					0	0	0.010504	0	0
TNN	63923	broad.mit.edu	37	1	175092555	175092555	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:175092555C>T	ENST00000239462.4	+	12	2783	c.2670C>T	c.(2668-2670)aaC>aaT	p.N890N		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	890	Fibronectin type-III 8.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCCCCAAAAACCTAGTGACTG	0.483000													13	57					0	0	0.001855	0	0
KIAA1429	25962	broad.mit.edu	37	8	95539567	95539567	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:95539567G>A	ENST00000297591.5	-	8	980	c.905C>T	c.(904-906)tCc>tTc	p.S302F	KIAA1429_ENST00000437199.1_Missense_Mutation_p.S302F|KIAA1429_ENST00000421249.2_Missense_Mutation_p.S302F	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	302	Glu-rich.				mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTCATCACTGGAAATTTGTTC	0.318000													6	16					0	0	0.001168	0	0
TMEM74	157753	broad.mit.edu	37	8	109796614	109796614	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:109796614G>A	ENST00000297459.3	-	2	892	c.714C>T	c.(712-714)ctC>ctT	p.L238L	TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74	238					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			CCAGCGTGAGGAGGCAGAGCC	0.602000													9	34					0	0	0.004482	0	0
DMXL2	23312	broad.mit.edu	37	15	51830595	51830595	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:51830595C>T	ENST00000251076.5	-	10	1447	c.1160G>A	c.(1159-1161)gGc>gAc	p.G387D	DMXL2_ENST00000543779.2_Missense_Mutation_p.G387D|DMXL2_ENST00000449909.3_Missense_Mutation_p.G387D	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	387						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		AACTACAAAGCCCCCATTTCC	0.299000													3	22					0	0	0.009096	0	0
TRIM24	8805	broad.mit.edu	37	7	138264074	138264074	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:138264074G>A	ENST00000343526.4	+	15	2597	c.2382G>A	c.(2380-2382)caG>caA	p.Q794Q	TRIM24_ENST00000415680.2_Silent_p.Q760Q			O15164	TIF1A_HUMAN	tripartite motif containing 24	794					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	40						GACTTCACCAGGACAATTCCT	0.478000													29	71					0	0	0.013726	0	0
ANKRD22	118932	broad.mit.edu	37	10	90583082	90583082	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:90583082G>A	ENST00000371930.4	-	5	663	c.453C>T	c.(451-453)atC>atT	p.I151I	ANKRD22_ENST00000476963.1_5'UTR	NM_144590.2	NP_653191.2	Q5VYY1	ANR22_HUMAN	ankyrin repeat domain 22	151										NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10		Colorectal(252;0.0163)		Colorectal(12;6.29e-05)|COAD - Colon adenocarcinoma(12;7.69e-05)		AGAGCAGAGGGATAAGAGACT	0.488000													22	109					0	0	0.003954	0	0
MUC16	94025	broad.mit.edu	37	19	9056720	9056720	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9056720C>T	ENST00000397910.4	-	3	30929	c.30726G>A	c.(30724-30726)ggG>ggA	p.G10242G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10244	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGAGGTTATCCCAGTGGACT	0.458000													12	51					0	0	0.010729	0	0
SYNRG	11276	broad.mit.edu	37	17	35902537	35902537	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:35902537G>A	ENST00000339208.6	-	15	2879	c.2739C>T	c.(2737-2739)ctC>ctT	p.L913L	SYNRG_ENST00000502449.2_Intron|SYNRG_ENST00000591288.1_Intron|SYNRG_ENST00000585472.1_Silent_p.L834L|SYNRG_ENST00000345615.4_Silent_p.L835L|SYNRG_ENST00000346661.4_Silent_p.L913L|SYNRG_ENST00000394378.2_Silent_p.L835L	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	913					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TTCCTGCTGAGAGGACAAATG	0.458000													10	95					0	0	0.006214	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947181	57947181	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:57947181G>A	ENST00000335397.3	+	3	581	c.265G>A	c.(265-267)Ggg>Agg	p.G89R		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				GCTGGAGCATGGGGCAGCTTT	0.527000													18	79					0	0	0.007413	0	0
SLX4	84464	broad.mit.edu	37	16	3639602	3639602	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:3639602G>A	ENST00000294008.3	-	12	4677	c.4037C>T	c.(4036-4038)cCc>cTc	p.P1346L		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1346	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CCCGGGGTGGGGACGGGAAGG	0.672000								Direct reversal of damage					23	131					0	0	0.003330	0	0
OBSCN	84033	broad.mit.edu	37	1	228560760	228560760	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:228560760G>A	ENST00000570156.2	+	105	25226	c.25152G>A	c.(25150-25152)cgG>cgA	p.R8384R	OBSCN_ENST00000422127.1_Silent_p.R7427R|OBSCN_ENST00000366707.4_Silent_p.R5061R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7427					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ACATCTCCCGGATCCTGAAGG	0.637000													9	29					0	0	0.006214	0	0
ZNF655	79027	broad.mit.edu	37	7	99159542	99159542	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:99159542C>T	ENST00000425063.1	+	3	270	c.168C>T	c.(166-168)ccC>ccT	p.P56P	ZNF655_ENST00000440391.1_Intron|ZNF655_ENST00000357864.2_Intron|ZNF655_ENST00000424881.1_Intron|ZNF655_ENST00000394163.2_Intron|ZNF655_ENST00000449244.1_Silent_p.P56P|ZNF655_ENST00000454654.1_Silent_p.P56P|ZNF655_ENST00000493277.1_Intron|ZNF655_ENST00000320583.5_Silent_p.P56P|ZNF655_ENST00000252713.4_Intron			Q8N720	ZN655_HUMAN	zinc finger protein 655	8					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CTGCTCTTCCCCGTGAGGGAA	0.597000													9	16					0	0	0.004482	0	0
HSD3B7	80270	broad.mit.edu	37	16	30999285	30999285	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:30999285C>T	ENST00000297679.5	+	7	984	c.891C>T	c.(889-891)ttC>ttT	p.F297F	HSD3B7_ENST00000262520.6_3'UTR|HSD3B7_ENST00000353250.5_3'UTR	NM_025193.3	NP_079469.2	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	297					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						TGCTGGTGTTCCTGGCTGCCC	0.657000													28	121					0	0	0.005443	0	0
BLNK	29760	broad.mit.edu	37	10	97960771	97960771	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:97960771G>A	ENST00000224337.5	-	14	1119	c.978C>T	c.(976-978)ccC>ccT	p.P326P	BLNK_ENST00000413476.2_Silent_p.P326P|BLNK_ENST00000371176.2_Silent_p.P303P|BLNK_ENST00000427367.2_Silent_p.P326P	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	326					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		ATGAAAAGCTGGGTAGGGGCC	0.398000													23	94					0	0	0.004656	0	0
GRM6	2916	broad.mit.edu	37	5	178417676	178417676	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:178417676C>T	ENST00000231188.5	-	4	1107	c.929G>A	c.(928-930)gGa>gAa	p.G310E	GRM6_ENST00000517717.1_Missense_Mutation_p.G310E	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	310					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GGTCTTGGCTCCCCAGCTGTC	0.667000													6	10					0	0	0.001168	0	0
SIDT2	51092	broad.mit.edu	37	11	117061423	117061423	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:117061423C>T	ENST00000324225.4	+	18	2233	c.1702C>T	c.(1702-1704)Cat>Tat	p.H568Y	SIDT2_ENST00000431081.2_Missense_Mutation_p.H565Y	NM_001040455.1	NP_001035545.1	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2	568						integral to membrane|lysosomal membrane				NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	36	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		TGCTTGCTATCATGTGTGCCC	0.537000													9	44					0	0	0.008291	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37486234	37486234	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:37486234C>T	ENST00000374660.1	+	34	2928	c.2829C>T	c.(2827-2829)ttC>ttT	p.F943F	ANKRD30A_ENST00000361713.1_Silent_p.F824F|ANKRD30A_ENST00000602533.1_Silent_p.F824F			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	997						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.F824F(1)		NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CATCTGCCTTCGAGGTATTTA	0.328000													15	101					0	0	0.004007	0	0
BTF3	689	broad.mit.edu	37	5	72798383	72798383	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:72798383C>T	ENST00000380591.3	+	3	491	c.272C>T	c.(271-273)tCc>tTc	p.S91F	BTF3_ENST00000335895.8_Missense_Mutation_p.S47F|BTF3_ENST00000514505.2_3'UTR	NM_001037637.1	NP_001032726.1	P20290	BTF3_HUMAN	basic transcription factor 3	91	NAC-A/B.			Missing (in Ref. 2; AAA58398).	regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(2)	5		Lung NSC(167;0.00405)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;2.73e-54)		CTTCAGTTCTCCTTAAAGAAG	0.378000													4	22					0	0	0.000602	0	0
CLSTN3	9746	broad.mit.edu	37	12	7288115	7288115	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:7288115C>T	ENST00000537408.1	+	3	1150	c.612C>T	c.(610-612)ttC>ttT	p.F204F	CLSTN3_ENST00000266546.6_Silent_p.F192F			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	192	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						ACACCCCTTTCCTCATTGACA	0.577000													16	94					0	0	0.004990	0	0
SAMD3	154075	broad.mit.edu	37	6	130497110	130497110	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:130497110C>T	ENST00000532763.1	-	7	821	c.692G>A	c.(691-693)cGa>cAa	p.R231Q	SAMD3_ENST00000533296.1_5'UTR|SAMD3_ENST00000457563.2_Missense_Mutation_p.R257Q|SAMD3_ENST00000439090.2_Missense_Mutation_p.R233Q|SAMD3_ENST00000437477.2_Missense_Mutation_p.R233Q|SAMD3_ENST00000368134.2_Missense_Mutation_p.R233Q			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	233										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TATGGGTCTTCGAACATATTT	0.343000													9	61					0	0	0.006214	0	0
DST	667	broad.mit.edu	37	6	56481609	56481609	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:56481609G>T	ENST00000370765.6	-	24	6763	c.6656C>A	c.(6655-6657)tCt>tAt	p.S2219Y	DST_ENST00000244364.6_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000312431.6_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1562					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGAAGAATAAGAATATCCCAC	0.413000													10	76					1.58986e-06	1.64737e-06	0.008291	1	0
CCDC73	493860	broad.mit.edu	37	11	32724469	32724469	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:32724469C>T	ENST00000531481.1	-	4	505	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K	CCDC73_ENST00000335185.5_Missense_Mutation_p.E77K|CCDC73_ENST00000534415.1_5'UTR			Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	77										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					GCCAATGTTTCCTTTTGATTC	0.318000													20	79					0	0	0.012319	0	0
ZDHHC2	51201	broad.mit.edu	37	8	17067464	17067464	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:17067464C>T	ENST00000262096.8	+	9	1449	c.754C>T	c.(754-756)Cga>Tga	p.R252*		NM_016353.4	NP_057437.1	Q9UIJ5	ZDHC2_HUMAN	zinc finger, DHHC-type containing 2	252						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|pancreas(1)|stomach(1)	8				Colorectal(111;0.0697)|COAD - Colon adenocarcinoma(73;0.244)		TCCAGTATTTCGACATGGAAC	0.343000													7	10					0	0	0.003080	0	0
ANO4	121601	broad.mit.edu	37	12	101493497	101493497	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:101493497G>A	ENST00000392979.3	+	21	2404	c.2044_splice	c.e21+1	p.M681_splice	ANO4_ENST00000392977.3_Splice_Site_p.M716_splice|ANO4_ENST00000550015.1_Splice_Site_p.M236_splice|ANO4_ENST00000299222.9_Splice_Site_p.M236_splice	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	716						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						ACTTAGAAATGAGTATGGAAA	0.348000										HNSCC(74;0.22)			6	27					0	0	0.001168	0	0
HDAC9	9734	broad.mit.edu	37	7	18631235	18631235	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:18631235C>T	ENST00000406451.3	+	5	653	c.503C>T	c.(502-504)tCc>tTc	p.S168F	HDAC9_ENST00000432645.2_Missense_Mutation_p.S168F|HDAC9_ENST00000406072.1_Missense_Mutation_p.S199F|HDAC9_ENST00000405010.3_Missense_Mutation_p.S168F|HDAC9_ENST00000417496.2_Missense_Mutation_p.S210F|HDAC9_ENST00000401921.1_Missense_Mutation_p.S171F|HDAC9_ENST00000441542.2_Missense_Mutation_p.S171F|HDAC9_ENST00000456174.2_Missense_Mutation_p.S140F|HDAC9_ENST00000524023.1_Missense_Mutation_p.S137F|HDAC9_ENST00000428307.2_Missense_Mutation_p.S168F	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	168					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	AAAAATCATTCCGTGAGCCGC	0.463000													21	46					0	0	0.014323	0	0
GALNT8	26290	broad.mit.edu	37	12	4829980	4829980	+	Missense_Mutation	SNP	C	C	T	rs150045663	byFrequency	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:4829980C>T	ENST00000252318.2	+	1	474	c.137C>T	c.(136-138)cCt>cTt	p.P46L	RP11-234B24.6_ENST00000544741.2_Intron	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	46						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						AGGGAGCTTCCTTTACATCTG	0.468000													20	73					0	0	0.012319	0	0
OR4C15	81309	broad.mit.edu	37	11	55322113	55322113	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:55322113C>T	ENST00000314644.2	+	1	331	c.331C>T	c.(331-333)Cct>Tct	p.P111S		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TCTGGTGTCTCCTATGTACTT	0.433000										HNSCC(20;0.049)			20	129					0	0	0.008871	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955419	18955419	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:18955419C>T	ENST00000302797.3	-	1	1137	c.913G>A	c.(913-915)Gga>Aga	p.G305R		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	305					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGCTGCCCTCCACCTTCATCC	0.552000													13	80					0	0	0.001855	0	0
PLCL2	23228	broad.mit.edu	37	3	17051844	17051844	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:17051844C>T	ENST00000418129.2	+	2	1093	c.628C>T	c.(628-630)Cat>Tat	p.H210Y	PLCL2_ENST00000396755.2_Missense_Mutation_p.H210Y|PLCL2_ENST00000432376.1_Missense_Mutation_p.H210Y|PLCL2_ENST00000460467.1_Intron	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	336	PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.H210Y(1)		breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						TGAGGTTTTTCATGAGCTTTG	0.338000													12	37					0	0	0.013537	0	0
TRPM7	54822	broad.mit.edu	37	15	50901824	50901824	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:50901824A>T	ENST00000313478.7	-	19	2815	c.2534T>A	c.(2533-2535)tTt>tAt	p.F845Y	TRPM7_ENST00000560955.1_Missense_Mutation_p.F845Y	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	845					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		AAAGGCATAAAACTTTCGCGT	0.323000													7	38					0	0	0.004482	0	0
KDM5C	8242	broad.mit.edu	37	X	53250049	53250049	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:53250049G>A	ENST00000375401.3	-	2	732	c.200C>T	c.(199-201)cCc>cTc	p.P67L	KDM5C_ENST00000404049.3_Missense_Mutation_p.P67L|KDM5C_ENST00000375379.3_Missense_Mutation_p.P67L|KDM5C_ENST00000375383.3_Missense_Mutation_p.P67L|KDM5C_ENST00000452825.3_Intron	NM_004187.3	NP_004178.2	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	67					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						CTGGATTCGGGGGGTAAACCT	0.507000			"""N, F, S"""		clear cell renal carcinoma								7	25					0	0	0.003080	0	0
MUC16	94025	broad.mit.edu	37	19	9073747	9073747	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9073747G>A	ENST00000397910.4	-	3	13902	c.13699C>T	c.(13699-13701)Cca>Tca	p.P4567S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4569	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAACCATTGGAGATGTGGCT	0.507000													9	52					0	0	0.006214	0	0
ZC3H13	23091	broad.mit.edu	37	13	46554046	46554046	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:46554046C>T	ENST00000242848.4	-	11	2162	c.1814G>A	c.(1813-1815)aGa>aAa	p.R605K	ZC3H13_ENST00000282007.3_Missense_Mutation_p.R605K			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	605	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		ATATCTATCTCTTTCAGGATA	0.438000													15	89					0	0	0.007413	0	0
MYO3B	140469	broad.mit.edu	37	2	171056776	171056776	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:171056776G>A	ENST00000334231.6	+	3	330	c.330G>A	c.(328-330)caG>caA	p.Q110Q	MYO3B_ENST00000408978.4_Silent_p.Q101Q|MYO3B_ENST00000409044.3_Silent_p.Q101Q|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	101	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						TAGGGGGACAGCTGTGGCTGG	0.453000													11	49					0	0	0.010729	0	0
DNAH5	1767	broad.mit.edu	37	5	13885104	13885104	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:13885104A>C	ENST00000265104.4	-	19	3081	c.2977T>G	c.(2977-2979)Ttc>Gtc	p.F993V	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	993	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTACCCCGGAAGTTAATTGTG	0.443000									Kartagener syndrome				16	66					0	0	0.008871	0	0
MAGEB2	4113	broad.mit.edu	37	X	30237634	30237634	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:30237634G>A	ENST00000378988.4	+	2	1038	c.937G>A	c.(937-939)Gat>Aat	p.D313N		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	313							protein binding			breast(1)|large_intestine(3)|lung(17)|ovary(1)|skin(1)	23						AGCTTTGAAAGATGAAGAGAA	0.488000													13	14					0	0	0.001855	0	0
RFC1	5981	broad.mit.edu	37	4	39304170	39304170	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:39304170G>A	ENST00000381897.1	-	18	2522	c.2389C>T	c.(2389-2391)Cct>Tct	p.P797S	RFC1_ENST00000349703.2_Missense_Mutation_p.P796S	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	797					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						ATAGCTGGAGGGGGAATCTTT	0.318000													7	33					0	0	0.004482	0	0
CSMD1	64478	broad.mit.edu	37	8	3263610	3263610	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:3263610G>A	ENST00000520002.1	-	16	2763	c.2208C>T	c.(2206-2208)tcC>tcT	p.S736S	CSMD1_ENST00000602723.1_Silent_p.S736S|CSMD1_ENST00000400186.3_Silent_p.S736S|CSMD1_ENST00000602557.1_Silent_p.S736S|CSMD1_ENST00000542608.1_Silent_p.S735S|CSMD1_ENST00000539096.1_Silent_p.S735S|CSMD1_ENST00000537824.1_Silent_p.S735S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	736	Sushi 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCAGGTAATGGACTCGGATC	0.547000													8	43					0	0	0.004482	0	0
ZNF479	90827	broad.mit.edu	37	7	57193746	57193746	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:57193746C>T	ENST00000331162.4	-	4	511	c.241G>A	c.(241-243)Gag>Aag	p.E81K		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	81	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			GCTACCATCTCATTTCTCTTT	0.413000													38	83					0	0	0.013114	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555176	44555176	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:44555176C>T	ENST00000330682.2	-	1	1273	c.1038G>A	c.(1036-1038)agG>agA	p.R346R	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	346	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						CCGGATTGTTCCTAGGCACCC	0.652000													19	1537					0	0	0.010729	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6425508	6425508	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:6425508G>A	ENST00000449001.2	+	6	1092	c.598G>A	c.(598-600)Gag>Aag	p.E200K	PLEKHG6_ENST00000396988.3_Missense_Mutation_p.E232K|PLEKHG6_ENST00000011684.7_Missense_Mutation_p.E232K|PLEKHG6_ENST00000536531.1_Missense_Mutation_p.E232K	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	232	DH.				regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						GCCCACCCTGGAGGAGACTCG	0.627000													3	7					0	0	0.004672	0	0
CMYA5	202333	broad.mit.edu	37	5	79033333	79033333	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:79033333G>A	ENST00000446378.2	+	2	8776	c.8745G>A	c.(8743-8745)aaG>aaA	p.K2915K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2915						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAATGCCCAAGGAACCTGAAG	0.383000													8	42					0	0	0.004482	0	0
DNAH17	8632	broad.mit.edu	37	17	76570873	76570873	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:76570873C>T	ENST00000389840.5	-	2	391	c.267G>A	c.(265-267)aaG>aaA	p.K89K	DNAH17_ENST00000585328.1_Silent_p.K89K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGTAGTTGTCCTTGTTGATGT	0.582000													20	111					0	0	0.012319	0	0
CACNA1D	776	broad.mit.edu	37	3	53844087	53844087	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:53844087C>T	ENST00000288139.3	+	48	6132	c.6014C>T	c.(6013-6015)cCa>cTa	p.P2005L	CACNA1D_ENST00000544977.1_3'UTR|CACNA1D_ENST00000422281.2_Missense_Mutation_p.P1961L|CACNA1D_ENST00000350061.5_Missense_Mutation_p.P1985L	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1985					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GCCACCCCTCCAGCAACCCCT	0.622000													12	60					0	0	0.010729	0	0
IGKV1-17	28937	broad.mit.edu	37	2	89417058	89417058	+	RNA	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:89417058G>A	ENST00000490686.1	-	0	152																											GGCAAGTGATGGTGACTCTGT	0.498000													29	149					0	0	0.012213	0	0
SCLT1	132320	broad.mit.edu	37	4	129867241	129867241	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:129867241G>A	ENST00000281142.5	-	16	1863	c.1360C>T	c.(1360-1362)Ctg>Ttg	p.L454L	SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000434680.1_Intron|SCLT1_ENST00000502495.1_5'UTR|SCLT1_ENST00000503215.1_Intron	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	454						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						TCTGAAACCAGGAATCTTTGG	0.348000													6	18					0	0	0.001168	0	0
CA1	759	broad.mit.edu	37	8	86250493	86250493	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:86250493C>T	ENST00000523953.1	-	4	1269	c.223G>A	c.(223-225)Gat>Aat	p.D75N	CA1_ENST00000518341.1_5'UTR|CA1_ENST00000523022.1_Missense_Mutation_p.D75N|CA1_ENST00000522389.1_Intron|CA1_ENST00000256119.5_Missense_Mutation_p.D75N|CA1_ENST00000432364.2_Missense_Mutation_p.D75N|CA1_ENST00000542576.1_Missense_Mutation_p.D75N|CA1_ENST00000431316.1_Missense_Mutation_p.D75N			P00915	CAH1_HUMAN	carbonic anhydrase I	75				DN -> ND (in Ref. 4; AA sequence and 5; AA sequence).	one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	13		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	GATCGGTTATCGTTGTCCTCA	0.398000													31	153					0	0	0.010818	0	0
OR5K1	26339	broad.mit.edu	37	3	98189104	98189104	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:98189104G>A	ENST00000332650.5	+	1	781	c.684G>A	c.(682-684)atG>atA	p.M228I		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTTTCAAAATGAAATCCAAAG	0.348000													5	48					0	0	0.000602	0	0
ITCH	83737	broad.mit.edu	37	20	33077189	33077189	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:33077189G>A	ENST00000374864.4	+	21	2425	c.2212G>A	c.(2212-2214)Gag>Aag	p.E738K	ITCH_ENST00000535650.1_Missense_Mutation_p.E628K|ITCH_ENST00000262650.6_Missense_Mutation_p.E779K	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	779	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity	p.E738Q(1)		NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						AAAGGAATTAGAGGTAATGAA	0.368000													7	73					0	0	0.003080	0	0
GRB14	2888	broad.mit.edu	37	2	165353901	165353901	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:165353901C>T	ENST00000263915.3	-	10	1742	c.1204G>A	c.(1204-1206)Gaa>Aaa	p.E402K	GRB14_ENST00000543549.1_Missense_Mutation_p.E315K	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	402					blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						GCGAGTCCTTCTTCAACCGCA	0.403000													16	82					0	0	0.007413	0	0
ASPM	259266	broad.mit.edu	37	1	197074187	197074187	+	Silent	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:197074187A>G	ENST00000367409.4	-	18	4450	c.4194T>C	c.(4192-4194)gtT>gtC	p.V1398V	ASPM_ENST00000367408.1_Intron|ASPM_ENST00000294732.7_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1398	IQ 2.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TCTGAATTGTAACTGTAGCCC	0.299000													17	62					0	0	0.007413	0	0
TRIM15	89870	broad.mit.edu	37	6	30131610	30131610	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:30131610C>T	ENST00000376694.4	+	1	618	c.149C>T	c.(148-150)tCc>tTc	p.S50F	TRIM15_ENST00000376688.1_Missense_Mutation_p.S50F	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	50					mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						GGGGCCCAATCCTCGGGCAAG	0.672000													6	63					0	0	0.003080	0	0
COL3A1	1281	broad.mit.edu	37	2	189870087	189870087	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:189870087G>A	ENST00000304636.3	+	41	3113	c.2943G>A	c.(2941-2943)ggG>ggA	p.G981G	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	981	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.G981G(1)		NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GTGAAAGTGGGAAACCAGGAG	0.428000													20	84					0	0	0.002780	0	0
FANCI	55215	broad.mit.edu	37	15	89807213	89807213	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:89807213G>A	ENST00000310775.7	+	8	711	c.625G>A	c.(625-627)Gaa>Aaa	p.E209K	FANCI_ENST00000451393.2_Missense_Mutation_p.E30K|FANCI_ENST00000300027.8_Missense_Mutation_p.E209K|FANCI_ENST00000567996.1_Missense_Mutation_p.E209K	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	209					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					GAATCTTCAAGAAATACCACC	0.418000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				16	56					0	0	0.004990	0	0
SETD1A	9739	broad.mit.edu	37	16	30991855	30991855	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:30991855C>T	ENST00000262519.8	+	15	5144	c.4458C>T	c.(4456-4458)ccC>ccT	p.P1486P		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	1486	Interaction with ASH2L, RBBP5 and WDR5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						AGGATGGGCCCCGGGAGCACC	0.642000													19	108					0	0	0.012319	0	0
HHIP	64399	broad.mit.edu	37	4	145628247	145628247	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:145628247C>T	ENST00000296575.3	+	6	1647	c.992C>T	c.(991-993)cCa>cTa	p.P331L		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	331						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		AGAAAAAATCCACACCAAGTT	0.383000													7	23					0	0	0.004482	0	0
GRM4	2914	broad.mit.edu	37	6	34101063	34101063	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:34101063T>C	ENST00000374181.3	-	1	380	c.211A>G	c.(211-213)Aag>Gag	p.K71E	GRM4_ENST00000538487.1_Missense_Mutation_p.K71E|GRM4_ENST00000374177.3_Intron	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	71					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	TTTTCCTTCTTAAGTTCTCCA	0.612000													6	52					0	0	0.001168	0	0
DNAH5	1767	broad.mit.edu	37	5	13721267	13721267	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:13721267G>A	ENST00000265104.4	-	71	12225	c.12121C>T	c.(12121-12123)Cca>Tca	p.P4041S		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4041	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGCGTCCGTGGATCAGATTCC	0.483000									Kartagener syndrome				19	82					0	0	0.012319	0	0
TTC37	9652	broad.mit.edu	37	5	94852915	94852915	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:94852915G>A	ENST00000358746.2	-	21	2524	c.2226C>T	c.(2224-2226)gtC>gtT	p.V742V		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	742							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						GACCTAGAAGGACTCCTAAAA	0.423000													5	30					0	0	0.001168	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72139246	72139246	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:72139246C>T	ENST00000555818.1	+	9	3359	c.3011C>T	c.(3010-3012)aCt>aTt	p.T1004I	SIPA1L1_ENST00000381232.3_Missense_Mutation_p.T1004I|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.T479I|SIPA1L1_ENST00000358550.2_Missense_Mutation_p.T1004I	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1004	PDZ.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GCGGTAGCCACTCTGAGCCAT	0.607000													16	36					0	0	0.003163	0	0
TINAG	27283	broad.mit.edu	37	6	54173382	54173382	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:54173382T>C	ENST00000259782.4	+	1	130	c.34T>C	c.(34-36)Tat>Cat	p.Y12H	TINAG_ENST00000370869.3_Intron|TINAG_ENST00000486436.1_Intron|TINAG_ENST00000370864.3_5'UTR	NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	12					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			AATCTTCTCTTATCTTACTAC	0.413000													10	48					0	0	0.006214	0	0
KIF4B	285643	broad.mit.edu	37	5	154394888	154394888	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:154394888C>T	ENST00000435029.4	+	1	1629	c.1469C>T	c.(1468-1470)aCt>aTt	p.T490I		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	490					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GCCATTGATACTGCGGTAGAA	0.448000													17	75					0	0	0.008871	0	0
SPHKAP	80309	broad.mit.edu	37	2	228886633	228886633	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:228886633C>T	ENST00000392056.3	-	6	537	c.491G>A	c.(490-492)aGa>aAa	p.R164K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.R164K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	164						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ACTGTTTGGTCTGTTCCCTCT	0.433000													7	24					0	0	0.001984	0	0
DUOXA1	90527	broad.mit.edu	37	15	45409845	45409845	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:45409845C>T	ENST00000267803.4	-	11	1719	c.1320G>A	c.(1318-1320)tcG>tcA	p.S440S	DUOXA1_ENST00000430224.2_Silent_p.S395S|DUOXA1_ENST00000558996.1_3'UTR|DUOXA2_ENST00000323030.5_Intron|DUOXA1_ENST00000559014.1_Silent_p.S440S	NM_144565.2	NP_653166.2	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	0					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		ggccagagttcgagaccagcc	0.607000													5	26					0	0	0.000602	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37033538	37033538	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:37033538C>T	ENST00000322716.5	-	1	1257	c.1031G>A	c.(1030-1032)aGa>aAa	p.R344K		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	344						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						AGTTTTCCCTCTCCTAAGCCA	0.413000													44	141					0	0	0.010771	0	0
CENPE	1062	broad.mit.edu	37	4	104067143	104067143	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:104067143A>G	ENST00000265148.3	-	30	4345	c.4256T>C	c.(4255-4257)aTa>aCa	p.I1419T	CENPE_ENST00000380026.3_Missense_Mutation_p.I1394T	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1419					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTCTATTTCTATCCTTAGTAG	0.368000													11	93					0	0	0.002450	0	0
CCNB3	85417	broad.mit.edu	37	X	50094333	50094333	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:50094333G>A	ENST00000376042.1	+	12	4352	c.4054G>A	c.(4054-4056)Gat>Aat	p.D1352N	CCNB3_ENST00000348603.2_Missense_Mutation_p.D248N|CCNB3_ENST00000276014.7_Missense_Mutation_p.D1352N|CCNB3_ENST00000376038.1_Missense_Mutation_p.D248N			Q8WWL7	CCNB3_HUMAN	cyclin B3	1352					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CAGTTCTTACGATAGTCTCAA	0.453000													36	61					0	0	0.003755	0	0
OR1F1	4992	broad.mit.edu	37	16	3255137	3255137	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:3255137G>A	ENST00000304646.2	+	1	891	c.891G>A	c.(889-891)ttG>ttA	p.L297L	AJ003147.9_ENST00000576468.1_RNA	NM_012360.1	NP_036492.1	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F, member 1	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(7)	11						ACAGGTACTTGAAAGGGGCTC	0.423000													18	58					0	0	0.007413	0	0
LEPREL1	55214	broad.mit.edu	37	3	189705396	189705396	+	Missense_Mutation	SNP	C	C	T	rs115909080	by1000genomes	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:189705396C>T	ENST00000319332.5	-	5	1215	c.1018G>A	c.(1018-1020)Gag>Aag	p.E340K	LEPREL1_ENST00000427335.2_Missense_Mutation_p.E159K	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	340					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AGGACATCCTCATCATCTGGA	0.463000													13	54					0	0	0.004007	0	0
LYZL4	131375	broad.mit.edu	37	3	42448470	42448470	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:42448470C>T	ENST00000287748.3	-	3	435	c.160G>A	c.(160-162)Gag>Aag	p.E54K	LYZL4_ENST00000470991.1_5'UTR|LYZL4_ENST00000441172.1_Missense_Mutation_p.E54K	NM_144634.2	NP_653235.1	Q96KX0	LYZL4_HUMAN	lysozyme-like 4	54					cell wall macromolecule catabolic process	extracellular region	lysozyme activity	p.E54K(1)		central_nervous_system(1)|endometrium(1)|lung(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.222)		AACTTGCTCTCGAAGTAGGCC	0.572000													6	29					0	0	0.001984	0	0
VWA5A	4013	broad.mit.edu	37	11	124005635	124005635	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:124005635C>T	ENST00000456829.2	+	12	1504	c.1253C>T	c.(1252-1254)tCa>tTa	p.S418L	VWA5A_ENST00000392748.1_Missense_Mutation_p.S418L|VWA5A_ENST00000360334.4_Intron	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	418	VWFA.									autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						AGGTGTTTCTCATTTGGTATT	0.408000													5	28					0	0	0.000602	0	0
MAP4	4134	broad.mit.edu	37	3	47896788	47896788	+	Missense_Mutation	SNP	C	C	T	rs148356137		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:47896788C>T	ENST00000426837.2	-	19	6733	c.6646G>A	c.(6646-6648)Gtg>Atg	p.V2216M	MAP4_ENST00000441748.2_Missense_Mutation_p.V185M|MAP4_ENST00000420772.2_Missense_Mutation_p.V764M|MAP4_ENST00000395734.3_Missense_Mutation_p.V1071M|MAP4_ENST00000383737.4_Missense_Mutation_p.V730M|MAP4_ENST00000360240.6_Missense_Mutation_p.V1071M|MAP4_ENST00000264724.11_Missense_Mutation_p.V806M			P27816	MAP4_HUMAN	microtubule-associated protein 4	1071					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		AGGGATCCCACCTTGGCCTGG	0.557000													21	111					0	0	0.004656	0	0
IFT172	26160	broad.mit.edu	37	2	27693920	27693920	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:27693920G>A	ENST00000260570.3	-	16	1670	c.1567C>T	c.(1567-1569)Ctc>Ttc	p.L523F		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	523					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					CAGAAGTTGAGGATCATTGTC	0.463000													6	41					0	0	0.001168	0	0
ZBBX	79740	broad.mit.edu	37	3	167083673	167083673	+	Splice_Site	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:167083673C>T	ENST00000392766.2	-	6	614		c.e6+1		ZBBX_ENST00000307529.5_Splice_Site|ZBBX_ENST00000392764.1_Splice_Site|ZBBX_ENST00000455345.2_Splice_Site|ZBBX_ENST00000392767.2_Splice_Site|ZBBX_ENST00000469220.1_Intron	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing							intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						TATCTTCTTACCTTAACAACA	0.303000													9	26					0	0	0.006214	0	0
NMRK2	27231	broad.mit.edu	37	19	3941164	3941164	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:3941164G>A	ENST00000168977.2	+	7	781	c.491G>A	c.(490-492)gGt>gAt	p.G164D	NMRK2_ENST00000593949.1_Missense_Mutation_p.G169D|NMRK2_ENST00000599576.1_Intron	NM_170678.2	NP_733778.1			nicotinamide riboside kinase 2																		GAGGCCAACGGTGTGGAAGTG	0.602000													28	114					0	0	0.006320	0	0
FAM220A	84792	broad.mit.edu	37	7	6370657	6370657	+	Silent	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:6370657T>C	ENST00000313324.4	-	2	596	c.129A>G	c.(127-129)gcA>gcG	p.A43A		NM_001037163.1	NP_001032240.1	Q7Z4H9	SIPAR_HUMAN	family with sequence similarity 220, member A	43						nucleus											TCCAGGAGGGTGCATCTGCAG	0.547000													13	67					0	0	0.002450	0	0
USP9Y	8287	broad.mit.edu	37	Y	14838532	14838532	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrY:14838532C>T	ENST00000338981.3	+	7	1408	c.463C>T	c.(463-465)Cgc>Tgc	p.R155C	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	155					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CAATACTCATCGCCTAGTGGA	0.348000													13	21					0	0	0.002450	0	0
BPTF	2186	broad.mit.edu	37	17	65850295	65850295	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:65850295G>A	ENST00000321892.4	+	2	914	c.853G>A	c.(853-855)Gag>Aag	p.E285K	BPTF_ENST00000335221.5_Missense_Mutation_p.E285K|BPTF_ENST00000424123.3_Missense_Mutation_p.E146K|BPTF_ENST00000306378.6_Missense_Mutation_p.E285K			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	285	DDT.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			ACTCATGGCAGAGATGCATGT	0.458000													24	89					0	0	0.014323	0	0
PROSC	11212	broad.mit.edu	37	8	37633494	37633494	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:37633494T>C	ENST00000328195.3	+	7	723	c.656T>C	c.(655-657)gTt>gCt	p.V219A		NM_007198.3	NP_009129.1	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog (bacterial)	219							pyridoxal phosphate binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)	7		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	GCTGACCAGGTTGAGCTGAGC	0.567000													22	121					0	0	0.003330	0	0
TTN	7273	broad.mit.edu	37	2	179615579	179615579	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:179615579C>T	ENST00000360870.5	-	46	11770	c.11548G>A	c.(11548-11550)Gag>Aag	p.E3850K	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000578746.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9685							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGATGACTCTCCAATTGTA	0.373000													8	84					0	0	0.003080	0	0
PRIM2	5558	broad.mit.edu	37	6	57398263	57398263	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:57398263G>A	ENST00000607273.1	+	10	1053	c.966G>A	c.(964-966)caG>caA	p.Q322Q	PRIM2_ENST00000389488.2_3'UTR	NM_000947.2	NP_000938.2	P49643	PRI2_HUMAN	primase, DNA, polypeptide 2 (58kDa)	322					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(34)|prostate(6)|stomach(4)|upper_aerodigestive_tract(1)	59				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CTTTGGAACAGACATTGCAGT	0.368000													6	167					0	0	0.004482	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077196	19077196	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:19077196C>T	ENST00000329773.2	-	2	841	c.754G>A	c.(754-756)Gat>Aat	p.D252N		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	252					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						ACATCAGAATCCTTCCAGATC	0.473000													6	55					0	0	0.003080	0	0
HYAL4	23553	broad.mit.edu	37	7	123517036	123517036	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:123517036G>A	ENST00000223026.4	+	5	1911	c.1273G>A	c.(1273-1275)Gac>Aac	p.D425N	HYAL4_ENST00000476325.1_Missense_Mutation_p.D425N	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	425					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						ATCTGATACAGACCTGGCAGT	0.488000													12	91					0	0	0.013537	0	0
FAM135B	51059	broad.mit.edu	37	8	139164014	139164014	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:139164014C>T	ENST00000395297.1	-	13	2874	c.2704G>A	c.(2704-2706)Gaa>Aaa	p.E902K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	902										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTTGGGGTTTCCTCAAGTGCT	0.473000										HNSCC(54;0.14)			22	82					0	0	0.003954	0	0
NLRP8	126205	broad.mit.edu	37	19	56465910	56465910	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:56465910C>T	ENST00000291971.3	+	3	557	c.486C>T	c.(484-486)ttC>ttT	p.F162F	NLRP8_ENST00000590542.1_Silent_p.F162F	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	162						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AAAAGTTTTTCCCCATATGGG	0.443000													9	53					0	0	0.008291	0	0
PALLD	23022	broad.mit.edu	37	4	169433032	169433032	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:169433032C>T	ENST00000261509.6	+	2	588	c.377C>T	c.(376-378)cCc>cTc	p.P126L	PALLD_ENST00000505667.1_Missense_Mutation_p.P126L|PALLD_ENST00000333488.4_Missense_Mutation_p.P3L|PALLD_ENST00000335742.7_5'UTR	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	126					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GCCATGTCACCCCTGCTCACC	0.512000									Pancreatic Cancer, Familial Clustering of				8	49					0	0	0.004482	0	0
UBIAD1	29914	broad.mit.edu	37	1	11345724	11345724	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:11345724C>T	ENST00000376810.5	+	2	879	c.553C>T	c.(553-555)Ctg>Ttg	p.L185L	UBIAD1_ENST00000376804.2_Intron	NM_013319.2	NP_037451.1	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	185					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		GTACGTGGCTCTGGGAGACCT	0.547000													9	42					0	0	0.006214	0	0
DEFA4	1669	broad.mit.edu	37	8	6794277	6794277	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:6794277C>T	ENST00000297435.2	-	2	269	c.145G>A	c.(145-147)Gat>Aat	p.D49N		NM_001925.1	NP_001916.1	P12838	DEF4_HUMAN	defensin, alpha 4, corticostatin	49					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	10				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		GAGCTTTTATCCCATGCAAAG	0.547000													13	63					0	0	0.002450	0	0
MAGI1	9223	broad.mit.edu	37	3	65415693	65415693	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:65415693G>A	ENST00000330909.8	-	12	1668	c.1669C>T	c.(1669-1671)Cca>Tca	p.P557S	MAGI1_ENST00000497477.2_Missense_Mutation_p.P557S|MAGI1_ENST00000483466.1_Missense_Mutation_p.P557S|MAGI1_ENST00000402939.2_Missense_Mutation_p.P557S	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	557					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		AAAGGCAATGGATAACCTCGG	0.463000													9	50					0	0	0.006214	0	0
SH3GL2	6456	broad.mit.edu	37	9	17787503	17787503	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:17787503G>A	ENST00000380607.4	+	5	577	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K	SH3GL2_ENST00000537391.1_Missense_Mutation_p.E106K	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	153	BAR.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		AGATCTTAGGGAAATTCAAGT	0.403000													6	39					0	0	0.001168	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841889	8841889	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:8841889C>T	ENST00000324060.2	+	1	574	c.499C>T	c.(499-501)Ccc>Tcc	p.P167S		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CCTGCATTTTCCCTACTGTGC	0.552000													31	128					0	0	0.004878	0	0
MARCH10	162333	broad.mit.edu	37	17	60814083	60814083	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:60814083C>T	ENST00000544856.2	-	7	1521	c.1143G>A	c.(1141-1143)agG>agA	p.R381R	RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000456609.2_Silent_p.R382R|MARCH10_ENST00000583600.1_Silent_p.R420R|MARCH10_ENST00000311269.5_Silent_p.R382R|RP11-156L14.1_ENST00000582564.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	382							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						TAGCAGATTCCCTATCAGGCA	0.537000													24	78					0	0	0.003330	0	0
CHGA	1113	broad.mit.edu	37	14	93398956	93398956	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:93398956G>T	ENST00000216492.5	+	7	1330	c.1050G>T	c.(1048-1050)aaG>aaT	p.K350N	CHGA_ENST00000334654.4_Missense_Mutation_p.K199N	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	350					regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		AGCTGGCCAAGGAGCTGACGG	0.652000													3	10					1.23904e-05	1.2826e-05	0.000602	1	0
KIAA0100	9703	broad.mit.edu	37	17	26955507	26955507	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:26955507G>A	ENST00000528896.2	-	24	4444	c.4370C>T	c.(4369-4371)tCc>tTc	p.S1457F	KIAA0100_ENST00000389003.3_Missense_Mutation_p.S1314F|KIAA0100_ENST00000544884.1_Missense_Mutation_p.S1314F	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	1457						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					AGTTGTCCAGGAAATCCGTAA	0.458000													19	68					0	0	0.008871	0	0
ETV6	2120	broad.mit.edu	37	12	12022746	12022746	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:12022746C>T	ENST00000396373.4	+	5	1126	c.852C>T	c.(850-852)tcC>tcT	p.S284S		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	284						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CCCGGCACTCCGTGGATTTCA	0.612000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								10	53					0	0	0.008291	0	0
OSMR	9180	broad.mit.edu	37	5	38881746	38881746	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:38881746G>A	ENST00000274276.3	+	4	700	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	OSMR_ENST00000502536.1_Missense_Mutation_p.E100K	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	100					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					TTGGAGCTGGGAATCTGAGCT	0.458000													15	81					0	0	0.003163	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133930700	133930700	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:133930700G>A	ENST00000298622.4	+	2	393	c.255G>A	c.(253-255)aaG>aaA	p.K85K		NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AGAAGATGAAGGAGCTACAGG	0.592000													8	43					0	0	0.003080	0	0
OR10X1	128367	broad.mit.edu	37	1	158549138	158549138	+	Silent	SNP	G	G	A	rs139262126		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:158549138G>A	ENST00000368150.1	-	1	551	c.552C>T	c.(550-552)ttC>ttT	p.F184F		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					TGGGTCTGCAGAAAGAGTCCC	0.428000													9	32					0	0	0.008291	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857498	9857498	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:9857498C>T	ENST00000396573.2	-	14	4212	c.3903G>A	c.(3901-3903)gaG>gaA	p.E1301E	GRIN2A_ENST00000330684.3_Silent_p.E1301E|GRIN2A_ENST00000535259.1_Intron|GRIN2A_ENST00000404927.2_Intron|GRIN2A_ENST00000396575.2_Silent_p.E1301E|GRIN2A_ENST00000562109.1_Intron	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1301					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TAAGGTCTAGCTCCCTAGGTT	0.502000													12	99					0	0	0.001855	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													4	45					0	0	0.009096	0	0
GHR	2690	broad.mit.edu	37	5	42719299	42719299	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:42719299G>A	ENST00000230882.4	+	10	1880	c.1690G>A	c.(1690-1692)Gac>Aac	p.D564N	GHR_ENST00000537449.1_Missense_Mutation_p.D377N|GHR_ENST00000357703.3_Missense_Mutation_p.D542N	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	564					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AAACCAAGAGGACATTTACAT	0.502000													3	19					0	0	0.004672	0	0
PPEF1	5475	broad.mit.edu	37	X	18748339	18748339	+	Silent	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:18748339T>C	ENST00000361511.4	+	5	581	c.87T>C	c.(85-87)ggT>ggC	p.G29G	PPEF1_ENST00000359763.6_Silent_p.G29G|PPEF1_ENST00000349874.5_Silent_p.G29G|PPEF1_ENST00000471570.1_3'UTR|PPEF1_ENST00000544635.1_Intron|PPEF1_ENST00000543630.1_Silent_p.G29G	NM_006240.2|NM_152224.1	NP_006231.2|NP_689410.1	O14829	PPE1_HUMAN	protein phosphatase, EF-hand calcium binding domain 1	29	IQ.				detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	43	Hepatocellular(33;0.183)					GGTACCGAGGTTACAAAGCTC	0.463000													16	29					0	0	0.003163	0	0
RP1	6101	broad.mit.edu	37	8	55540511	55540511	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:55540511G>A	ENST00000220676.1	+	4	4217	c.4069G>A	c.(4069-4071)Gat>Aat	p.D1357N		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1357					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGATAACTTGGATTCAACTGA	0.353000													7	40					0	0	0.006214	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092868	151092868	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:151092868G>A	ENST00000360243.2	+	3	999	c.732G>A	c.(730-732)agG>agA	p.R244R	MAGEA4_ENST00000393920.1_Silent_p.R244R|MAGEA4_ENST00000393921.1_Silent_p.R244R|MAGEA4_ENST00000370335.1_Silent_p.R244R|MAGEA4_ENST00000370337.4_Silent_p.R244R|MAGEA4_ENST00000370340.3_Silent_p.R244R|MAGEA4_ENST00000276344.2_Silent_p.R244R	NM_001011550.1	NP_001011550.1	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	244	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GGGAGCCCAGGAAACTGCTCA	0.592000													21	57					0	0	0.010504	0	0
ZDHHC11	79844	broad.mit.edu	37	5	843743	843743	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:843743C>T	ENST00000283441.8	-	4	983	c.600G>A	c.(598-600)ggG>ggA	p.G200G	ZDHHC11_ENST00000511539.1_5'UTR|ZDHHC11_ENST00000424784.2_Silent_p.G200G	NM_024786.2	NP_079062.1	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	200						integral to membrane	acyltransferase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(10)|pancreas(1)|prostate(5)|skin(2)|urinary_tract(1)	21			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			TGCGGAGCACCCCGGGGTTCA	0.632000													13	131					0	0	0.002450	0	0
CRTC1	23373	broad.mit.edu	37	19	18853784	18853784	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:18853784C>T	ENST00000338797.6	+	2	216	c.191C>T	c.(190-192)tCc>tTc	p.S64F	CRTC1_ENST00000594658.1_Missense_Mutation_p.S23F|CRTC1_ENST00000321949.8_Missense_Mutation_p.S64F|CRTC1_ENST00000601916.1_5'UTR	NM_001098482.1	NP_001091952.1	Q6UUV9	CRTC1_HUMAN	CREB regulated transcription coactivator 1	64					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	19						TATGGCGGGTCCCTGCCCAAC	0.667000													12	34					0	0	0.002450	0	0
TAF6	6878	broad.mit.edu	37	7	99708909	99708909	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:99708909G>A	ENST00000344095.4	-	10	1461	c.936C>T	c.(934-936)atC>atT	p.I312I	TAF6_ENST00000437822.2_Silent_p.I349I|TAF6_ENST00000452041.1_Silent_p.I312I|TAF6_ENST00000453269.2_Silent_p.I312I|TAF6_ENST00000418432.2_Silent_p.I236I|TAF6_ENST00000472509.1_Silent_p.I369I	NM_005641.3	NP_005632.1	P49848	TAF6_HUMAN	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	312					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTCTGCTCACGATGCAGGTCA	0.527000													30	54					0	0	0.008361	0	0
RSPH9	221421	broad.mit.edu	37	6	43612929	43612929	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:43612929C>T	ENST00000372165.4	+	1	147	c.94C>T	c.(94-96)Ctt>Ttt	p.L32F	RSPH9_ENST00000372163.4_Missense_Mutation_p.L32F	NM_001193341.1	NP_001180270.1	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog (Chlamydomonas)	32					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						GCTCACGTCTCTTATGCTGGT	0.642000									Kartagener syndrome				21	73					0	0	0.002780	0	0
NLE1	54475	broad.mit.edu	37	17	33464057	33464057	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:33464057G>A	ENST00000442241.4	-	7	830	c.791C>T	c.(790-792)tCc>tTc	p.S264F	NLE1_ENST00000360831.5_Missense_Mutation_p.S222F|NLE1_ENST00000586869.1_5'UTR|NLE1_ENST00000593176.1_5'UTR	NM_001014445.1|NM_018096.3	NP_001014445.1|NP_060566.2	Q9NVX2	NLE1_HUMAN	notchless homolog 1 (Drosophila)	264						nucleolus				NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	22		Ovarian(249;0.17)				GCGGTCCTGGGAGGCAGAGTA	0.597000													15	101					0	0	0.012319	0	0
CCDC27	148870	broad.mit.edu	37	1	3673352	3673352	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:3673352G>A	ENST00000294600.2	+	4	693	c.609G>A	c.(607-609)agG>agA	p.R203R		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	203										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TGCGGAAGAGGAGAAAATCCC	0.547000													15	89					0	0	0.003163	0	0
SP140	11262	broad.mit.edu	37	2	231174672	231174672	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:231174672G>A	ENST00000392045.3	+	23	2206	c.2092G>A	c.(2092-2094)Gac>Aac	p.D698N	SP140_ENST00000417495.3_Missense_Mutation_p.D584N|SP140_ENST00000350136.5_Missense_Mutation_p.D567N|SP140_ENST00000420434.3_Missense_Mutation_p.D671N|SP140_ENST00000486687.2_Missense_Mutation_p.D622N|SP140_ENST00000343805.6_Missense_Mutation_p.D638N	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	698					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GGTGTGCCGGGACGGAGGGGA	0.542000													20	116					0	0	0.003330	0	0
TC2N	123036	broad.mit.edu	37	14	92264212	92264212	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:92264212C>T	ENST00000435962.2	-	8	1095	c.772G>A	c.(772-774)Gac>Aac	p.D258N	TC2N_ENST00000556018.1_Missense_Mutation_p.D258N|TC2N_ENST00000340892.5_Missense_Mutation_p.D258N|TC2N_ENST00000360594.5_Missense_Mutation_p.D258N	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	258						nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		GTAGGAGTGTCTCCATAACTA	0.343000													13	57					0	0	0.001855	0	0
CAPN10	11132	broad.mit.edu	37	2	241534660	241534660	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:241534660C>T	ENST00000391984.2	+	7	1413	c.1217C>T	c.(1216-1218)tCg>tTg	p.S406L	CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000391982.2_Missense_Mutation_p.S406L|CAPN10_ENST00000404753.3_Missense_Mutation_p.S406L|CAPN10_ENST00000354082.4_Missense_Mutation_p.S406L|CAPN10_ENST00000352879.4_Intron	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	406	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		AGTCATACTTCGTGGAGCCCA	0.652000													11	44					0	0	0.013537	0	0
GCNT1	2650	broad.mit.edu	37	9	79117943	79117943	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:79117943C>T	ENST00000442371.1	+	3	1585	c.646C>T	c.(646-648)Ctt>Ttt	p.L216F	GCNT1_ENST00000376730.4_Missense_Mutation_p.L216F|GCNT1_ENST00000444201.2_Missense_Mutation_p.L216F|GCNT1_ENST00000536223.1_Missense_Mutation_p.L216F	NM_001097634.1	NP_001091103.1	Q02742	GCNT1_HUMAN	glucosaminyl (N-acetyl) transferase 1, core 2	216	Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(11)|prostate(2)|urinary_tract(1)	30						CTTGATAAATCTTTGTGGTAT	0.443000													15	39					0	0	0.002450	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013347	73013347	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:73013347G>A	ENST00000308744.6	+	4	1485	c.1387G>A	c.(1387-1389)Gaa>Aaa	p.E463K	NPFFR2_ENST00000395999.1_Missense_Mutation_p.E364K|NPFFR2_ENST00000358749.3_Missense_Mutation_p.E361K|NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000344413.5_3'UTR	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	463					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			AAAGCCTATGGAAGCTTATGC	0.433000													19	74					0	0	0.007413	0	0
PKDCC	91461	broad.mit.edu	37	2	42280439	42280439	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:42280439G>A	ENST00000294964.5	+	2	880	c.700G>A	c.(700-702)Gag>Aag	p.E234K		NM_138370.2	NP_612379.2	Q504Y2	PKDCC_HUMAN	protein kinase domain containing, cytoplasmic	234	Protein kinase.				cell differentiation|embryonic digestive tract development|lung alveolus development|negative regulation of Golgi to plasma membrane protein transport|ossification|palate development|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|protein transport	Golgi apparatus	ATP binding|protein kinase activity			breast(2)|kidney(1)|lung(5)	8						CACCATCACGGAGCTGGGCGC	0.612000													17	115					0	0	0.006122	0	0
PTPRC	5788	broad.mit.edu	37	1	198711437	198711437	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:198711437G>A	ENST00000367376.2	+	25	2803	c.2632G>A	c.(2632-2634)Gat>Aat	p.D878N	PTPRC_ENST00000352140.3_Missense_Mutation_p.D830N|PTPRC_ENST00000348564.6_Missense_Mutation_p.D719N|PTPRC_ENST00000442510.2_Missense_Mutation_p.D880N|PTPRC_ENST00000594404.1_Missense_Mutation_p.D717N	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	878	Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GAACAAAGTGGATGTTTATGG	0.438000													23	92					0	0	0.012319	0	0
SLC38A10	124565	broad.mit.edu	37	17	79249826	79249826	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:79249826G>A	ENST00000374759.3	-	8	1238	c.855C>T	c.(853-855)ttC>ttT	p.F285F	SLC38A10_ENST00000546352.1_5'UTR|SLC38A10_ENST00000288439.5_Silent_p.F285F	NM_001037984.1	NP_001033073.1	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10	285					amino acid transport|sodium ion transport	integral to membrane				NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TCATCATGGGGAAGCCCACAG	0.612000													16	62					0	0	0.004007	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711814	155711814	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:155711814C>T	ENST00000295101.2	+	3	1972	c.1495C>T	c.(1495-1497)Cgc>Tgc	p.R499C		NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	499					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding	p.R499G(1)		breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	GAACTCTGATCGCTTCACATA	0.408000													5	17					0	0	0.000602	0	0
RP11-50E11.3	0	broad.mit.edu	37	10	52389901	52389901	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:52389901C>T	ENST00000443374.1	+	0	594																											GGGTCGTTTTCCTGAAAAATT	0.408000													5	11					0	0	0.001168	0	0
ITPR3	3710	broad.mit.edu	37	6	33636832	33636832	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:33636832G>C	ENST00000374316.5	+	19	3148	c.2088G>C	c.(2086-2088)tgG>tgC	p.W696C	ITPR3_ENST00000605930.1_Missense_Mutation_p.W696C			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	696					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GGCTCACGTGGACTGACAAGA	0.587000													21	112					0	0	0.002780	0	0
KLK8	11202	broad.mit.edu	37	19	51503822	51503822	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:51503822C>T	ENST00000600767.1	-	4	577	c.88G>A	c.(88-90)Gag>Aag	p.E30K	KLK9_ENST00000376832.4_3'UTR|KLK9_ENST00000250366.6_3'UTR|KLK8_ENST00000347619.4_Intron|KLK8_ENST00000391806.2_Missense_Mutation_p.E75K|KLK8_ENST00000320838.5_Intron|KLK8_ENST00000593490.1_Intron|CTB-147C22.9_ENST00000594512.1_RNA|KLK8_ENST00000291726.7_Missense_Mutation_p.E30K			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	30					cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		ACCTTGTCCTCCTGTGCCCTG	0.632000													6	58					0	0	0.001168	0	0
ARHGAP25	9938	broad.mit.edu	37	2	68962338	68962338	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:68962338C>T	ENST00000295381.3	+	1	426	c.7C>T	c.(7-9)Cta>Tta	p.L3L	ARHGAP25_ENST00000409202.3_Silent_p.L3L|ARHGAP25_ENST00000467265.1_Silent_p.L3L|ARHGAP25_ENST00000456116.2_3'UTR|ARHGAP25_ENST00000544262.1_Intron	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	3					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						CAAAATGTCCCTAAAATTGCC	0.433000													12	75					0	0	0.010729	0	0
ABCG8	64241	broad.mit.edu	37	2	44079912	44079912	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:44079912C>T	ENST00000272286.2	+	6	959	c.869C>T	c.(868-870)aCc>aTc	p.T290I		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	290	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity	p.T290N(1)		NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ACGTCTGGCACCCCCATCTAC	0.582000													70	393					0	0	0.014410	0	0
C3P1	388503	broad.mit.edu	37	19	10157494	10157494	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:10157494C>T	ENST00000495140.1	+	0	1093																				endometrium(4)|large_intestine(2)|lung(6)|urinary_tract(1)	13						GGAGGAAGTTCACTCTGCCAA	0.527000													17	64					0	0	0.012319	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307642	140307642	+	Missense_Mutation	SNP	G	G	A	rs150006101		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:140307642G>A	ENST00000253807.2	+	1	1165	c.1165G>A	c.(1165-1167)Gct>Act	p.A389T	PCDHA3_ENST00000522353.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.A389T|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGCTGACGGCTTCCTTTGA	0.507000													9	44					0	0	0.010729	0	0
CHCHD5	84269	broad.mit.edu	37	2	113343995	113343995	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:113343995C>T	ENST00000409719.1	+	3	415	c.362C>T	c.(361-363)tCc>tTc	p.S121F	CHCHD5_ENST00000324913.5_Intron			Q9BSY4	CHCH5_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 5	0										NS(1)|endometrium(1)|large_intestine(4)|urinary_tract(1)	7						TCCCcttcatccttctggttg	0.537000													4	12					0	0	0.009096	0	0
TAAR5	9038	broad.mit.edu	37	6	132910326	132910326	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:132910326G>A	ENST00000258034.2	-	1	551	c.500C>T	c.(499-501)tCg>tTg	p.S167L		NM_003967.2	NP_003958.2	O14804	TAAR5_HUMAN	trace amine associated receptor 5	167					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity	p.S167*(1)		breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	32	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		GAGGAATAACGAAGTGTATGC	0.547000													25	69					0	0	0.004656	0	0
SLC22A10	387775	broad.mit.edu	37	11	63057858	63057858	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:63057858G>A	ENST00000332793.6	+	1	223	c.221G>A	c.(220-222)aGa>aAa	p.R74K	SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000544661.1_5'UTR|SLC22A10_ENST00000526800.1_Missense_Mutation_p.R22K|SLC22A10_ENST00000525620.1_Intron	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	74						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GCCCTCTTGAGAATCTCTATC	0.502000													9	79					0	0	0.006214	0	0
KRT3	3850	broad.mit.edu	37	12	53189556	53189556	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:53189556C>T	ENST00000417996.2	-	1	345	c.271G>A	c.(271-273)Ggt>Agt	p.G91S	KRT3_ENST00000309505.3_Missense_Mutation_p.G91S	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	91	Gly-rich.|Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						ccatagccacctgcaaagGCA	0.637000													14	80					0	0	0.001855	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39171438	39171438	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:39171438G>A	ENST00000297668.6	-	8	1334	c.1261C>T	c.(1261-1263)Ctc>Ttc	p.L421F	CNTNAP3_ENST00000358144.2_Missense_Mutation_p.L333F|CNTNAP3_ENST00000377659.1_Missense_Mutation_p.L421F|CNTNAP3_ENST00000323947.7_Missense_Mutation_p.L421F|CNTNAP3_ENST00000377656.2_Missense_Mutation_p.L421F	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	421	Laminin G-like 2.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTAAGAAAGAGGACGAAACTC	0.483000													15	84					0	0	0.002450	0	0
PLXDC2	84898	broad.mit.edu	37	10	20506496	20506496	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:20506496C>T	ENST00000377252.3	+	11	2105	c.1264C>T	c.(1264-1266)Cct>Tct	p.P422S	PLXDC2_ENST00000377238.2_3'UTR|PLXDC2_ENST00000377242.3_Missense_Mutation_p.P373S	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	422	Thr-rich.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						CACCAGCCTCCCTACAGAAGG	0.428000													11	22					0	0	0.013537	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665951	19665951	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:19665951G>A	ENST00000328041.6	+	12	1467	c.1270G>A	c.(1270-1272)Gaa>Aaa	p.E424K		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	424	Poly-Glu.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						tgatgaggaggaagaggagga	0.532000													10	56					0	0	0.010729	0	0
AKAP3	10566	broad.mit.edu	37	12	4737612	4737612	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:4737612G>C	ENST00000545990.2	-	5	980	c.456C>G	c.(454-456)aaC>aaG	p.N152K	AKAP3_ENST00000228850.1_Missense_Mutation_p.N152K	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	152					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						AGACACATTTGTTTTCAGAGC	0.453000													31	120					0	0	0.005524	0	0
ATP13A4	84239	broad.mit.edu	37	3	193180552	193180552	+	Splice_Site	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:193180552C>T	ENST00000342695.4	-	13	1844	c.1523_splice	c.e13+1	p.G508_splice	ATP13A4_ENST00000392443.3_Splice_Site_p.G489_splice|ATP13A4_ENST00000295548.3_Splice_Site_p.G508_splice	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	508					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GGTACTCACCCATTCCTATCA	0.428000													8	59					0	0	0.008291	0	0
PDE3A	5139	broad.mit.edu	37	12	20833104	20833104	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:20833104C>T	ENST00000359062.3	+	16	3365	c.3325C>T	c.(3325-3327)Cag>Tag	p.Q1109*	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	1109					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCAGACCCCTCAGTCGCACTC	0.488000													13	50					0	0	0.013537	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500082	90500082	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:90500082C>T	ENST00000325643.5	+	4	746	c.680C>T	c.(679-681)cCc>cTc	p.P227L		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CCACCAGAGCCCTTGCTTCCC	0.627000													41	130					0	0	0.011902	0	0
TNFRSF8	943	broad.mit.edu	37	1	12202505	12202505	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:12202505C>T	ENST00000263932.2	+	15	1927	c.1705C>T	c.(1705-1707)Ctg>Ttg	p.L569L	TNFRSF8_ENST00000479933.2_3'UTR|TNFRSF8_ENST00000417814.2_Silent_p.L457L|TNFRSF8_ENST00000413146.2_Silent_p.L106L	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	569					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		AGAACCGCCTCTGGGCAGCTG	0.667000													8	21					0	0	0.006214	0	0
CCDC157	550631	broad.mit.edu	37	22	30772336	30772336	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:30772336G>A	ENST00000405659.1	+	11	2655	c.1946_splice	c.e11+1	p.G649_splice	CCDC157_ENST00000338306.3_Splice_Site_p.G649_splice|RP1-130H16.16_ENST00000332468.4_RNA			Q569K6	CC157_HUMAN	coiled-coil domain containing 157	649										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(1)	15						ACATCCCCAGGGTGAGTGAGG	0.577000													13	43					0	0	0.002450	0	0
SH3RF2	153769	broad.mit.edu	37	5	145439612	145439612	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:145439612C>T	ENST00000511217.1	+	8	1791	c.1739C>T	c.(1738-1740)cCc>cTc	p.P580L	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Missense_Mutation_p.P580L			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	580							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACGGGGGAGCCCGCCCTCACG	0.632000													8	39					0	0	0.004482	0	0
TP63	8626	broad.mit.edu	37	3	189608638	189608638	+	Silent	SNP	C	C	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:189608638C>A	ENST00000264731.3	+	13	1802	c.1713C>A	c.(1711-1713)acC>acA	p.T571T	TP63_ENST00000320472.5_Intron|TP63_ENST00000392461.3_Intron|TP63_ENST00000440651.2_Silent_p.T567T|TP63_ENST00000392463.2_Intron|TP63_ENST00000392460.3_Intron|TP63_ENST00000354600.5_Silent_p.T477T|TP63_ENST00000456148.1_Silent_p.T473T|TP63_ENST00000449992.1_Silent_p.T392T|TP63_ENST00000382063.4_Silent_p.T486T	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	571	SAM.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.T571T(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		AGGGGCTGACCACCATCTATC	0.438000										HNSCC(45;0.13)			4	65					0.00909568	0.00935152	0.009096	1	0
B3GALT5	10317	broad.mit.edu	37	21	41032912	41032912	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr21:41032912C>T	ENST00000380620.3	+	5	1018	c.426C>T	c.(424-426)gtC>gtT	p.V142V	AF064860.5_ENST00000416555.1_RNA|B3GALT5_ENST00000343118.4_Silent_p.V142V|B3GALT5_ENST00000380618.1_Silent_p.V142V|B3GALT5_ENST00000398714.2_Silent_p.V142V			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	142					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				TAGAATGGGTCCATCGCTTTT	0.463000													10	93					0	0	0.010729	0	0
PLXNB1	5364	broad.mit.edu	37	3	48454245	48454245	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:48454245C>T	ENST00000358536.4	-	25	5029	c.4760G>A	c.(4759-4761)cGg>cAg	p.R1587Q	PLXNB1_ENST00000358459.4_Missense_Mutation_p.R1404Q|PLXNB1_ENST00000456774.1_Missense_Mutation_p.R1404Q|PLXNB1_ENST00000296440.6_Missense_Mutation_p.R1587Q|PLXNB1_ENST00000448774.2_Missense_Mutation_p.R198Q	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1587					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACCCAGGTCCCGGTGCAAGGG	0.627000													7	39					0	0	0.003080	0	0
KCNH1	3756	broad.mit.edu	37	1	211276866	211276866	+	Silent	SNP	G	G	A	rs138645753	byFrequency	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:211276866G>A	ENST00000367007.4	-	3	451	c.282C>T	c.(280-282)tcC>tcT	p.S94S	KCNH1_ENST00000271751.4_Silent_p.S94S	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	94	PAC.|PAS.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GAATTTCAAAGGAATTCATCT	0.358000													9	32					0	0	0.004482	0	0
SREBF1	6720	broad.mit.edu	37	17	17720736	17720736	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:17720736C>T	ENST00000355815.4	-	9	1699	c.1530G>A	c.(1528-1530)cgG>cgA	p.R510R	SREBF1_ENST00000395757.1_Silent_p.R226R|SREBF1_ENST00000261646.5_Silent_p.R480R|SREBF1_ENST00000338854.5_Silent_p.R480R	NM_001005291.2	NP_001005291.1	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription factor 1	480					cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	14						CCAGCATGCCCCGGCTGTGCA	0.697000													5	16					0	0	0.001168	0	0
GPR115	221393	broad.mit.edu	37	6	47682046	47682046	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:47682046G>A	ENST00000283303.2	+	6	1323	c.1065G>A	c.(1063-1065)aaG>aaA	p.K355K	GPR115_ENST00000327753.3_Silent_p.K355K|GPR115_ENST00000371220.1_Silent_p.K412K	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	355	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						GGCACTCCAAGAAAAGGAGAT	0.453000													11	73					0	0	0.008291	0	0
GPR25	2848	broad.mit.edu	37	1	200843206	200843206	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:200843206C>T	ENST00000304244.2	+	1	1124	c.1041C>T	c.(1039-1041)ttC>ttT	p.F347F		NM_005298.2	NP_005289.2	O00155	GPR25_HUMAN	G protein-coupled receptor 25	347						integral to plasma membrane				large_intestine(1)|lung(2)|ovary(1)|skin(1)	5						GTTCCGTGTTCCGTTGCCGGG	0.741000													4	10					0	0	0.009096	0	0
CDH5	1003	broad.mit.edu	37	16	66436825	66436825	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:66436825G>A	ENST00000341529.3	+	12	2256	c.2108G>A	c.(2107-2109)gGg>gAg	p.G703E	CDH5_ENST00000539168.1_Missense_Mutation_p.G142E	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	703					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GGAGGGCCCGGGGAGATGGCA	0.721000													17	29					0	0	0.010504	0	0
IQGAP2	10788	broad.mit.edu	37	5	75757427	75757427	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:75757427G>A	ENST00000274364.6	+	2	376	c.79G>A	c.(79-81)Gag>Aag	p.E27K	IQGAP2_ENST00000379730.3_5'UTR	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	27					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CTCTGCAGAGGAGATGGATGA	0.418000													10	49					0	0	0.008291	0	0
IGSF22	283284	broad.mit.edu	37	11	18732255	18732255	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:18732255C>T	ENST00000513874.1	-	16	2658	c.2519G>A	c.(2518-2520)cGa>cAa	p.R840Q	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	838	Fibronectin type-III 2.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						TTTCTTCCTTCGTTCTACAAT	0.567000													10	46					0	0	0.006214	0	0
CD53	963	broad.mit.edu	37	1	111439353	111439353	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:111439353G>A	ENST00000271324.5	+	6	614	c.502G>A	c.(502-504)Gag>Aag	p.E168K	CD53_ENST00000429072.2_Intron|CD53_ENST00000497404.1_Intron	NM_000560.3|NM_001040033.1	NP_000551.1|NP_001035122.1	P19397	CD53_HUMAN	CD53 molecule	168					signal transduction	integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)	17		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		TCGAAAAGTGGAGGTAATTTT	0.438000													12	79					0	0	0.010729	0	0
TAGAP	117289	broad.mit.edu	37	6	159457419	159457419	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:159457419C>T	ENST00000367066.3	-	10	1967	c.1636G>A	c.(1636-1638)Gaa>Aaa	p.E546K	RP1-111C20.4_ENST00000606470.1_RNA|TAGAP_ENST00000326965.6_Missense_Mutation_p.E368K|RP1-111C20.4_ENST00000606466.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000607391.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	546					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		AGCTGGCTTTCCTTTCTGACA	0.582000													9	129					0	0	0.004482	0	0
TSEN34	79042	broad.mit.edu	37	19	54696217	54696217	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:54696217C>T	ENST00000396383.1	+	4	1049	c.738C>T	c.(736-738)gtC>gtT	p.V246V	TSEN34_ENST00000302937.4_Silent_p.V246V|TSEN34_ENST00000429671.2_Silent_p.V246V|TSEN34_ENST00000396388.2_Silent_p.V246V			Q9BSV6	SEN34_HUMAN	TSEN34 tRNA splicing endonuclease subunit	246					mRNA processing|tRNA-type intron splice site recognition and cleavage	nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	10	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ACTTCCTGGTCTATCCTGGTG	0.512000													22	101					0	0	0.003954	0	0
PDZD2	23037	broad.mit.edu	37	5	32091151	32091151	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:32091151G>A	ENST00000438447.1	+	20	7985	c.7597G>A	c.(7597-7599)Gag>Aag	p.E2533K	PDZD2_ENST00000282493.3_Missense_Mutation_p.E2533K			O15018	PDZD2_HUMAN	PDZ domain containing 2	2533					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						TTCGTGTCCCGAGAAGGGCGG	0.617000													10	51					0	0	0.010729	0	0
L3MBTL4	91133	broad.mit.edu	37	18	5969551	5969551	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:5969551C>T	ENST00000284898.6	-	18	1682	c.1482G>A	c.(1480-1482)gtG>gtA	p.V494V	L3MBTL4_ENST00000317931.7_Silent_p.V485V|L3MBTL4_ENST00000400105.2_Silent_p.V494V|L3MBTL4_ENST00000535782.1_Silent_p.V298V	NM_173464.3	NP_775735.2	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	494					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding	p.V494V(1)		breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				GCGCCTGCTCCACCGAGTATT	0.627000													15	30					0	0	0.004990	0	0
GPC5	2262	broad.mit.edu	37	13	92408644	92408644	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:92408644C>T	ENST00000377067.3	+	5	1622	c.1250C>T	c.(1249-1251)cCc>cTc	p.P417L	GPC5_ENST00000483422.1_3'UTR	NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	417						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GATGGACTTCCCTGCTGGAAT	0.393000													13	70					0	0	0.003163	0	0
FAM83B	222584	broad.mit.edu	37	6	54806232	54806232	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:54806232C>T	ENST00000306858.7	+	5	2579	c.2463C>T	c.(2461-2463)gaC>gaT	p.D821D		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	821										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AGAAATCAGACACAAAAGTTG	0.378000													6	31					0	0	0.001984	0	0
CA10	56934	broad.mit.edu	37	17	50149681	50149681	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:50149681G>A	ENST00000451037.2	-	2	1074	c.134C>T	c.(133-135)cCa>cTa	p.P45L	CA10_ENST00000285273.4_Missense_Mutation_p.P45L|CA10_ENST00000340813.6_Missense_Mutation_p.P51L|CA10_ENST00000442502.2_Missense_Mutation_p.P45L|CA10_ENST00000570565.1_5'UTR	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	45					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GTACTTACCTGGAACAAAGCT	0.368000													11	61					0	0	0.013537	0	0
IL3RA	3563	broad.mit.edu	37	X	1464208	1464208	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:1464208G>A	ENST00000331035.4	+	3	413		c.e3-1		IL3RA_ENST00000381469.2_Intron	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)							integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CACCGTTTTAGATCCAAACCC	0.428000													47	171					0	0	0.014410	0	0
GPR61	83873	broad.mit.edu	37	1	110086967	110086967	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:110086967C>T	ENST00000527748.1	+	2	2006	c.1323C>T	c.(1321-1323)ctC>ctT	p.L441L		NM_031936.4	NP_114142.3	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	441						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	23		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		ACAGCTACCTCCGTCCTGCCG	0.587000													6	21					0	0	0.004482	0	0
OR4D10	390197	broad.mit.edu	37	11	59245499	59245499	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:59245499G>A	ENST00000530162.1	+	1	654	c.597G>A	c.(595-597)atG>atA	p.M199I		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AACTACTAATGATTTCCAACA	0.463000													8	61					0	0	0.003080	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626927	108626927	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:108626927G>A	ENST00000264047.2	+	9	1629	c.1353G>A	c.(1351-1353)gaG>gaA	p.E451E	SLC5A7_ENST00000409059.1_Silent_p.E451E|SLC5A7_ENST00000540517.1_Silent_p.E346E	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	451					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	CTGGAGGGGAGCCATATCTGT	0.448000													11	58					0	0	0.010729	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881126	228881126	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:228881126G>A	ENST00000392056.3	-	7	4490	c.4444C>T	c.(4444-4446)Cat>Tat	p.H1482Y	SPHKAP_ENST00000344657.5_Missense_Mutation_p.H1482Y	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1482						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ACTCACCTATGGATTTGACAA	0.443000													29	142					0	0	0.012213	0	0
C1orf158	93190	broad.mit.edu	37	1	12820745	12820745	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:12820745G>A	ENST00000288048.5	+	4	662	c.446G>A	c.(445-447)aGa>aAa	p.R149K	C1orf158_ENST00000376210.3_Missense_Mutation_p.R111K	NM_152290.2	NP_689503.2	Q8N1D5	CA158_HUMAN	chromosome 1 open reading frame 158	149										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|ovary(1)|skin(2)|urinary_tract(3)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CTCAAGCAGAGACAGCTCACA	0.542000													6	49					0	0	0.001168	0	0
ALDH9A1	223	broad.mit.edu	37	1	165649914	165649914	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:165649914G>A	ENST00000354775.4	-	5	903	c.599C>T	c.(598-600)gCc>gTc	p.A200V	ALDH9A1_ENST00000538148.1_Missense_Mutation_p.A106V|ALDH9A1_ENST00000461664.1_5'UTR	NM_000696.3	NP_000687.3	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9 family, member A1	176					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	21	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	AAAGACCATGGCATTACCTGC	0.428000													21	64					0	0	0.002780	0	0
GH2	2689	broad.mit.edu	37	17	61958081	61958081	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:61958081C>T	ENST00000332800.7	-	4	640	c.507G>A	c.(505-507)agG>agA	p.R169R	GH2_ENST00000449787.2_Intron|GH2_ENST00000423893.2_Intron|GH2_ENST00000456543.2_Intron	NM_002059.4|NM_022557.3|NM_022558.3	NP_002050.1|NP_072051.1|NP_072052.1	P01242	SOM2_HUMAN	growth hormone 2	0						extracellular region	hormone activity			breast(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	24						CTCCCCAGTCCCTGGAAGCCA	0.577000													22	89					0	0	0.002780	0	0
OR13C5	138799	broad.mit.edu	37	9	107361077	107361077	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:107361077G>A	ENST00000374779.2	-	1	711	c.618C>T	c.(616-618)ttC>ttT	p.F206F		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						GTGTCAATAGGAACAATGTTG	0.398000													15	79					0	0	0.002450	0	0
TRIM60	166655	broad.mit.edu	37	4	165962409	165962409	+	Silent	SNP	T	T	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:165962409T>G	ENST00000512596.1	+	3	1401	c.1185T>G	c.(1183-1185)ggT>ggG	p.G395G	TRIM60_ENST00000341062.5_Silent_p.G395G|TRIM60_ENST00000508504.1_Silent_p.G395G	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	395	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		TGAAGAGTGGTTATGTTGCGT	0.453000													13	84					0	0	0.002450	0	0
ELFN2	114794	broad.mit.edu	37	22	37770430	37770430	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:37770430G>A	ENST00000402918.1	-	3	1930	c.1145C>T	c.(1144-1146)cCc>cTc	p.P382L	ELFN2_ENST00000349653.3_Missense_Mutation_p.P382L|RP1-63G5.5_ENST00000430883.1_RNA	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	382						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					TCCGGGGACGGGGTCCCGCGT	0.637000													9	60					0	0	0.004482	0	0
OTUD7B	56957	broad.mit.edu	37	1	149939391	149939391	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:149939391G>A	ENST00000369135.3	-	4	624	c.330C>T	c.(328-330)gcC>gcT	p.A110A	OTUD7B_ENST00000479905.1_Intron	NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	110					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			CATGGGACCGGGCCAGGGAAA	0.552000													23	60					0	0	0.004656	0	0
OBSCN	84033	broad.mit.edu	37	1	228509380	228509380	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:228509380C>G	ENST00000570156.2	+	66	17783	c.17709C>G	c.(17707-17709)atC>atG	p.I5903M	OBSCN_ENST00000284548.11_Missense_Mutation_p.I4946M|OBSCN_ENST00000422127.1_Missense_Mutation_p.I4946M|OBSCN_ENST00000366707.4_Missense_Mutation_p.I2580M|OBSCN_ENST00000366709.4_Missense_Mutation_p.I2065M	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4946	PH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ACCATCACATCGACCAGCTTG	0.622000													14	42					0	0	0.002450	0	0
CD109	135228	broad.mit.edu	37	6	74407162	74407162	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:74407162C>T	ENST00000437994.2	+	2	545	c.114C>T	c.(112-114)ccC>ccT	p.P38P	CD109_ENST00000287097.5_Silent_p.P38P|CD109_ENST00000422508.2_Silent_p.P38P	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	38						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TCATCAGGCCCGGAGGAAATG	0.502000													41	106					0	0	0.010771	0	0
CD163L1	283316	broad.mit.edu	37	12	7526091	7526091	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:7526091G>A	ENST00000313599.3	-	14	3612	c.3555C>T	c.(3553-3555)ggC>ggT	p.G1185G	CD163L1_ENST00000396630.1_Silent_p.G1185G|CD163L1_ENST00000416109.2_Silent_p.G1195G			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1185	SRCR 11.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TCTCCCCACAGCCCAGCTGCC	0.542000													40	122					0	0	0.006999	0	0
ICAM5	7087	broad.mit.edu	37	19	10403726	10403726	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:10403726G>A	ENST00000221980.4	+	6	1332	c.1269G>A	c.(1267-1269)gaG>gaA	p.E423E		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	423	Ig-like C2-type 5.				cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CGTGGCCCGAGGGCCCAGAGC	0.692000													16	66					0	0	0.004007	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10527420	10527420	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:10527420G>A	ENST00000396560.2	+	4	1101	c.874G>A	c.(874-876)Gaa>Aaa	p.E292K	ATF7IP2_ENST00000356427.2_Missense_Mutation_p.E292K|ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000396559.1_Missense_Mutation_p.E292K|ATF7IP2_ENST00000324570.5_Missense_Mutation_p.E292K	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						AGAAAACGAGGAAAATGTTAA	0.333000													7	38					0	0	0.001984	0	0
CATSPERD	257062	broad.mit.edu	37	19	5739414	5739414	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:5739414G>A	ENST00000381624.3	+	7	598	c.537G>A	c.(535-537)ggG>ggA	p.G179G	CATSPERD_ENST00000381614.2_5'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	179						integral to membrane											CAAATACTGGGGGATTCAGTT	0.299000													17	71					0	0	0.010504	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058476	152058476	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:152058476C>T	ENST00000368806.1	-	3	1746	c.1682G>A	c.(1681-1683)aGc>aAc	p.S561N		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	561							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TGTCTCTGAGCTGCTATTGCC	0.537000													36	113					0	0	0.003271	0	0
RYR1	6261	broad.mit.edu	37	19	39001196	39001196	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:39001196C>T	ENST00000355481.4	+	59	9122	c.8991C>T	c.(8989-8991)ttC>ttT	p.F2997F	RYR1_ENST00000360985.3_Silent_p.F2997F|RYR1_ENST00000359596.3_Silent_p.F2997F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2997					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGATTAAATTCTTTGCCAAGG	0.562000													23	78					0	0	0.003954	0	0
CACNA1D	776	broad.mit.edu	37	3	53844086	53844086	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:53844086C>T	ENST00000288139.3	+	48	6131	c.6013C>T	c.(6013-6015)Cca>Tca	p.P2005S	CACNA1D_ENST00000544977.1_3'UTR|CACNA1D_ENST00000422281.2_Missense_Mutation_p.P1961S|CACNA1D_ENST00000350061.5_Missense_Mutation_p.P1985S	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1985					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGCCACCCCTCCAGCAACCCC	0.622000													12	60					0	0	0.010729	0	0
RIMS1	22999	broad.mit.edu	37	6	73000453	73000453	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:73000453G>A	ENST00000521978.1	+	25	3626	c.3626G>A	c.(3625-3627)gGa>gAa	p.G1209E	RIMS1_ENST00000538414.1_Intron|RIMS1_ENST00000520567.1_Intron|RIMS1_ENST00000523963.1_Intron|RIMS1_ENST00000522291.1_Intron|RIMS1_ENST00000491071.2_Intron|RIMS1_ENST00000517960.1_Intron|RIMS1_ENST00000518273.1_Intron|RIMS1_ENST00000348717.5_Intron|RIMS1_ENST00000264839.7_Intron|RIMS1_ENST00000517827.1_Intron|RIMS1_ENST00000401910.3_Intron|RIMS1_ENST00000425662.2_Intron	NM_014989.5	NP_055804.2	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1209					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GTCATTAGGGGAAAACATCCT	0.517000													12	31					0	0	0.001855	0	0
PDK4	5166	broad.mit.edu	37	7	95217039	95217039	+	Splice_Site	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:95217039C>T	ENST00000005178.5	-	8	1067	c.870_splice	c.e8+1	p.K290_splice		NM_002612.3	NP_002603.1	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase, isozyme 4	290	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			GAATGGTTACCTTAATGGTAA	0.383000													4	33					0	0	0.009096	0	0
CYP2A13	1553	broad.mit.edu	37	19	41601665	41601665	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:41601665G>A	ENST00000330436.3	+	9	1304	c.1303_splice	c.e9-1	p.G435_splice		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	435					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	TCCTCCTCAGGAAAGCGGTAC	0.577000													18	90					0	0	0.006122	0	0
PTPN3	5774	broad.mit.edu	37	9	112144595	112144595	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:112144595G>A	ENST00000412145.1	-	19	4675	c.2122C>T	c.(2122-2124)Cta>Tta	p.L708L	PTPN3_ENST00000374541.2_Silent_p.L839L|PTPN3_ENST00000394827.3_Silent_p.L307L|PTPN3_ENST00000262539.3_Silent_p.L685L|PTPN3_ENST00000446349.1_Silent_p.L663L	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	839	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						CAGTGAACTAGGACGGGCTCG	0.547000													5	17					0	0	0.000602	0	0
GTPBP1	9567	broad.mit.edu	37	22	39112978	39112978	+	Silent	SNP	C	C	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:39112978C>G	ENST00000216044.5	+	4	1040	c.807C>G	c.(805-807)ggC>ggG	p.G269G		NM_004286.4	NP_004277.2	O00178	GTPB1_HUMAN	GTP binding protein 1	269					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	18	Melanoma(58;0.04)					GCATGACAGGCCATCTGCCTG	0.537000													11	54					0	0	0.010729	0	0
OR52N4	390072	broad.mit.edu	37	11	5776098	5776098	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:5776098G>A	ENST00000317254.3	+	1	176	c.128G>A	c.(127-129)gGg>gAg	p.G43E	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		GCTATGGTAGGGAATTGTGGA	0.453000													15	73					0	0	0.002450	0	0
GOLGA3	2802	broad.mit.edu	37	12	133385019	133385019	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:133385019G>A	ENST00000204726.3	-	5	1194	c.636C>T	c.(634-636)ttC>ttT	p.F212F	GOLGA3_ENST00000456883.2_Silent_p.F212F|GOLGA3_ENST00000545875.1_Silent_p.F212F|GOLGA3_ENST00000537452.1_Silent_p.F212F|GOLGA3_ENST00000450791.2_Silent_p.F212F	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	212	Golgi-targeting domain.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TGGTGCGCAGGAAGGAATATT	0.507000													60	274					0	0	0.014410	0	0
CDK14	5218	broad.mit.edu	37	7	90747450	90747450	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:90747450G>A	ENST00000406263.1	+	13	1669	c.1227G>A	c.(1225-1227)ggG>ggA	p.G409G	CDK14_ENST00000436577.2_Silent_p.G326G|CDK14_ENST00000265741.3_Silent_p.G437G|CDK14_ENST00000380050.3_Silent_p.G455G			O94921	CDK14_HUMAN	cyclin-dependent kinase 14	455	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(12)|ovary(1)|skin(4)	32						GGGCCTTTGGGAAAAACAATA	0.418000													5	48					0	0	0.000602	0	0
ALPI	248	broad.mit.edu	37	2	233322995	233322995	+	Missense_Mutation	SNP	G	G	A	rs151137290		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:233322995G>A	ENST00000295463.3	+	9	1137	c.1060G>A	c.(1060-1062)Gac>Aac	p.D354N		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	354					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding	p.D354N(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGTCATGTTCGACGACGCCAT	0.622000													14	66					0	0	0.002450	0	0
SLC24A1	9187	broad.mit.edu	37	15	65917969	65917969	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:65917969C>T	ENST00000261892.6	+	2	1838	c.1551C>T	c.(1549-1551)ttC>ttT	p.F517F	SLC24A1_ENST00000546330.1_Silent_p.F517F|SLC24A1_ENST00000339868.6_Silent_p.F517F|SLC24A1_ENST00000544319.2_Silent_p.F517F|SLC24A1_ENST00000537259.1_Silent_p.F517F|SLC24A1_ENST00000399033.4_Silent_p.F517F	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	517					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						TCGGTGTCTTCATTTCCCACA	0.542000													17	77					0	0	0.006122	0	0
OC90	729330	broad.mit.edu	37	8	133044155	133044155	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:133044155C>T	ENST00000262283.5	-	16	1739	c.1640G>A	c.(1639-1641)aGa>aAa	p.R547K	OC90_ENST00000254627.3_Missense_Mutation_p.R335K|OC90_ENST00000603859.1_Missense_Mutation_p.R335K|OC90_ENST00000443356.2_Missense_Mutation_p.R351K			Q02509	OC90_HUMAN	otoconin 90	351					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TGGCTCGCCTCTTCCTTCTTG	0.547000													5	40					0	0	0.000602	0	0
PPIP5K1	9677	broad.mit.edu	37	15	43873490	43873490	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:43873490G>A	ENST00000420765.1	-	9	1056	c.874C>T	c.(874-876)Cga>Tga	p.R292*	PPIP5K1_ENST00000381885.1_Nonsense_Mutation_p.R292*|PPIP5K1_ENST00000360301.4_Nonsense_Mutation_p.R292*|PPIP5K1_ENST00000360135.4_Nonsense_Mutation_p.R292*|PPIP5K1_ENST00000381879.4_Nonsense_Mutation_p.R292*|PPIP5K1_ENST00000334933.4_Nonsense_Mutation_p.R292*|PPIP5K1_ENST00000432870.3_5'UTR|PPIP5K1_ENST00000396923.3_Nonsense_Mutation_p.R292*|PPIP5K1_ENST00000348806.6_Nonsense_Mutation_p.R292*	NM_001130858.2	NP_001124330.1	Q6PFW1	VIP1_HUMAN	diphosphoinositol pentakisphosphate kinase 1	292					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity	p.R292*(1)		large_intestine(1)	1						ACTGGATATCGAATCTCTTTC	0.512000													32	306					0	0	0.003755	0	0
GDPD4	220032	broad.mit.edu	37	11	76982231	76982231	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:76982231A>C	ENST00000315938.4	-	6	594	c.344T>G	c.(343-345)gTg>gGg	p.V115G	GDPD4_ENST00000376217.2_Missense_Mutation_p.V115G	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	115					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						GATAACCATCACAGTTATGCT	0.488000													14	40					0	0	0.004007	0	0
JAG1	182	broad.mit.edu	37	20	10625626	10625626	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:10625626G>A	ENST00000254958.5	-	18	2744	c.2227_splice	c.e18-1	p.A743_splice	JAG1_ENST00000423891.2_Splice_Site_p.A584_splice	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	743					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						TACTGTTTCGGGCTATAAAAG	0.567000									Alagille Syndrome				39	195					0	0	0.010771	0	0
TTN	7273	broad.mit.edu	37	2	179486223	179486223	+	Missense_Mutation	SNP	C	C	T	rs17354992	by1000genomes	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:179486223C>T	ENST00000589042.1	-	245	45552	c.45328G>A	c.(45328-45330)Gat>Aat	p.D15110N	TTN_ENST00000342992.6_Missense_Mutation_p.D12542N|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D6237N|TTN_ENST00000460472.2_Missense_Mutation_p.D6045N|TTN_ENST00000591111.1_Missense_Mutation_p.D13469N|TTN_ENST00000359218.5_Missense_Mutation_p.D6170N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589907.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13469							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTTGCCATCGGTTCGAGAG	0.398000													13	54					0	0	0.003163	0	0
MICAL1	64780	broad.mit.edu	37	6	109768899	109768899	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:109768899C>T	ENST00000368952.4	-	15	2318	c.2028G>A	c.(2026-2028)aaG>aaA	p.K676K	MICAL1_ENST00000358807.3_Silent_p.K657K|MICAL1_ENST00000358577.3_Silent_p.K571K			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	657					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		AGCGCAGCTTCTTGCCACCAG	0.517000													23	129					0	0	0.005443	0	0
TIE1	7075	broad.mit.edu	37	1	43778840	43778840	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:43778840C>T	ENST00000372476.3	+	13	2041	c.1962C>T	c.(1960-1962)gcC>gcT	p.A654A	TIE1_ENST00000433781.2_Silent_p.A299A	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	654	Fibronectin type-III 3.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACGCCCAGGCCCTCTCAGACT	0.647000													13	40					0	0	0.002450	0	0
MALAT1	378938	broad.mit.edu	37	11	65273128	65273128	+	RNA	SNP	T	T	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:65273128T>G	ENST00000534336.1	+	0	7896					NR_002819.2																						CATAATCGGTTTCAAGGTAAC	0.473000													17	84					0	0	0.007413	0	0
SIDT1	54847	broad.mit.edu	37	3	113330992	113330992	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:113330992C>T	ENST00000264852.4	+	19	2643	c.1917C>T	c.(1915-1917)gcC>gcT	p.A639A	SIDT1_ENST00000393830.3_Silent_p.A639A|SIDT1_ENST00000463226.1_3'UTR	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	639						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						ACGTTCTGGCCTCGCTAGCCC	0.413000													18	72					0	0	0.012319	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24259525	24259525	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:24259525C>T	ENST00000538205.1	+	13	1550	c.1003C>T	c.(1003-1005)Cct>Tct	p.P335S	RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000256412.4_Missense_Mutation_p.P414S|ADAMDEC1_ENST00000522298.1_Missense_Mutation_p.P335S	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	414	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		AGCACCTATTCCTACAAATAT	0.393000													5	50					0	0	0.000602	0	0
PTGIS	5740	broad.mit.edu	37	20	48130930	48130930	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:48130930C>T	ENST00000244043.4	-	7	887	c.858G>A	c.(856-858)ggG>ggA	p.G286G	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	286					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	GACCCATATTCCCCTGCAAGG	0.597000													12	31					0	0	0.010729	0	0
LGALS12	85329	broad.mit.edu	37	11	63276341	63276341	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:63276341C>T	ENST00000415491.2	+	2	747	c.133C>T	c.(133-135)Cat>Tat	p.H45Y	LGALS12_ENST00000425950.2_Missense_Mutation_p.H45Y|LGALS12_ENST00000340246.5_Missense_Mutation_p.H107Y|LGALS12_ENST00000255684.5_Missense_Mutation_p.H106Y|LGALS12_ENST00000394618.3_Missense_Mutation_p.H106Y	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	106					apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						CACCAAGCCCCATGTCATCTG	0.607000													19	60					0	0	0.006122	0	0
CDH12	1010	broad.mit.edu	37	5	21765107	21765107	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:21765107C>T	ENST00000382254.1	-	12	2581	c.1495G>A	c.(1495-1497)Gaa>Aaa	p.E499K	CDH12_ENST00000522262.1_Missense_Mutation_p.E459K|CDH12_ENST00000521384.1_5'UTR|RP11-804N13.1_ENST00000522350.1_RNA|CDH12_ENST00000504376.2_Missense_Mutation_p.E499K	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	499	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TTGGCATTTTCACACACGGCT	0.353000										HNSCC(59;0.17)			10	71					0	0	0.008291	0	0
ROCK1	6093	broad.mit.edu	37	18	18588072	18588072	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:18588072G>A	ENST00000399799.1	-	14	2434	c.1494C>T	c.(1492-1494)taC>taT	p.Y498Y		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	498	Interaction with FHOD1.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					CTTTTCTTTGGTACTCATTAA	0.313000													6	18					0	0	0.001168	0	0
GRIK3	2899	broad.mit.edu	37	1	37270690	37270690	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:37270690G>A	ENST00000373091.3	-	15	2479	c.2463C>T	c.(2461-2463)atC>atT	p.I821I	GRIK3_ENST00000373093.4_Silent_p.I821I	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	821					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AGATGCCCCCGATCTTCTGGA	0.597000													18	82					0	0	0.008871	0	0
IL37	27178	broad.mit.edu	37	2	113675263	113675263	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:113675263G>A	ENST00000263326.3	+	4	359	c.317G>A	c.(316-318)gGa>gAa	p.G106E	IL37_ENST00000353225.3_Missense_Mutation_p.G66E|IL37_ENST00000349806.3_Missense_Mutation_p.G45E|IL37_ENST00000352179.3_Missense_Mutation_p.G85E|IL37_ENST00000311328.2_Missense_Mutation_p.G80E	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37	106					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						GCGGAGAAAGGAAGTCCGATT	0.483000													34	139					0	0	0.012213	0	0
THSD7B	80731	broad.mit.edu	37	2	137917931	137917931	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:137917931G>A	ENST00000409968.1	+	6	1696	c.1518G>A	c.(1516-1518)ggG>ggA	p.G506G	THSD7B_ENST00000485379.1_3'UTR|THSD7B_ENST00000272643.3_Silent_p.G506G|THSD7B_ENST00000413152.2_Silent_p.G475G|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATCCTCAGGGGAAAAAAGGTG	0.468000													9	42					0	0	0.013537	0	0
SRGAP3	9901	broad.mit.edu	37	3	9069797	9069797	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:9069797C>T	ENST00000360413.3	-	12	1715	c.1454G>A	c.(1453-1455)cGa>cAa	p.R485Q	SRGAP3_ENST00000433332.3_5'UTR|SRGAP3_ENST00000383836.3_Intron	NM_001033117.2	NP_001028289.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	492	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GTTCCTGGTTCGAGCATTTCT	0.428000			T	RAF1	pilocytic astrocytoma								12	92					0	0	0.003163	0	0
DNAH10	196385	broad.mit.edu	37	12	124337761	124337761	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:124337761G>A	ENST00000409039.3	+	35	5971	c.5946G>A	c.(5944-5946)gcG>gcA	p.A1982A		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1982	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGACTCTGGCGAAAAAGATGA	0.403000													5	4					0	0	0.000602	0	0
SLC36A3	285641	broad.mit.edu	37	5	150666947	150666947	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:150666947G>A	ENST00000335230.3	-	6	979	c.568C>T	c.(568-570)Cgt>Tgt	p.R190C	SLC36A3_ENST00000377713.3_Missense_Mutation_p.R231C	NM_181774.3	NP_861439.3	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3	190			R -> H (in dbSNP:rs17660042).			integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	21		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGTAGAAACGAATGTCCAGG	0.512000													13	61					0	0	0.013537	0	0
COL4A1	1282	broad.mit.edu	37	13	110825088	110825088	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:110825088G>A	ENST00000375820.4	-	41	3656	c.3535C>T	c.(3535-3537)Cca>Tca	p.P1179S		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1179	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TTGGCCCCTGGAAACCCTGGG	0.468000													33	104					0	0	0.006230	0	0
URB2	9816	broad.mit.edu	37	1	229770924	229770924	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:229770924C>T	ENST00000258243.2	+	4	700	c.564C>T	c.(562-564)gtC>gtT	p.V188V		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	188						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						AGCAGCAGGTCAACCCAAGAC	0.612000													11	56					0	0	0.010729	0	0
TACR3	6870	broad.mit.edu	37	4	104640404	104640404	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:104640404G>A	ENST00000304883.2	-	1	569	c.429C>T	c.(427-429)ttC>ttT	p.F143F		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	143						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GCGCGTAGATGAAATTGACCA	0.532000													11	33					0	0	0.001855	0	0
SAMD3	154075	broad.mit.edu	37	6	130467282	130467282	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:130467282C>T	ENST00000368134.2	-	12	1676	c.1068G>A	c.(1066-1068)aaG>aaA	p.K356K	SAMD3_ENST00000457563.2_Silent_p.K380K|SAMD3_ENST00000439090.2_Silent_p.K356K|SAMD3_ENST00000437477.2_Silent_p.K356K	NM_001258275.1	NP_001245204.1	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	356										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		GCCTTGTTTTCTTATAAATAT	0.308000													7	45					0	0	0.001984	0	0
CEP76	79959	broad.mit.edu	37	18	12674678	12674678	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:12674678A>C	ENST00000262127.2	-	11	1923	c.1698T>G	c.(1696-1698)ttT>ttG	p.F566L	CEP76_ENST00000423709.2_Missense_Mutation_p.F491L|RP11-973H7.2_ENST00000585331.1_RNA	NM_024899.2	NP_079175.2	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	566					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TTGTACGCTCAAATTCATAAG	0.408000													14	39					0	0	0.001855	0	0
FBN3	84467	broad.mit.edu	37	19	8203108	8203108	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:8203108G>A	ENST00000600128.1	-	10	1532	c.1118C>T	c.(1117-1119)cCc>cTc	p.P373L	FBN3_ENST00000270509.2_Missense_Mutation_p.P373L|FBN3_ENST00000601739.1_Missense_Mutation_p.P373L			Q75N90	FBN3_HUMAN	fibrillin 3	373						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CCCAAGAGGGGGACCCATGCC	0.657000													12	39					0	0	0.013537	0	0
FER1L6	654463	broad.mit.edu	37	8	125076659	125076659	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:125076659C>T	ENST00000522917.1	+	26	3606	c.3400C>T	c.(3400-3402)Cac>Tac	p.H1134Y	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.H1134Y	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1134						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCCAGCAGATCACATTTATGT	0.572000													28	125					0	0	0.009535	0	0
PDZD2	23037	broad.mit.edu	37	5	32053928	32053928	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:32053928G>A	ENST00000438447.1	+	10	2227	c.1839G>A	c.(1837-1839)ggG>ggA	p.G613G	PDZD2_ENST00000282493.3_Silent_p.G613G			O15018	PDZD2_HUMAN	PDZ domain containing 2	613	PDZ 3.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GACAGATGGGGATTTTTGTCA	0.478000													25	134					0	0	0.009535	0	0
TECTA	7007	broad.mit.edu	37	11	121028895	121028895	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:121028895G>A	ENST00000392793.1	+	14	4922	c.4651G>A	c.(4651-4653)Gaa>Aaa	p.E1551K	TECTA_ENST00000264037.2_Missense_Mutation_p.E1551K			O75443	TECTA_HUMAN	tectorin alpha	1551	VWFD 4.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CTACATTAACGAAGAGCAGAT	0.537000													14	58					0	0	0.003163	0	0
DYSF	8291	broad.mit.edu	37	2	71780958	71780958	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:71780958C>G	ENST00000258104.3	+	21	2229	c.1952C>G	c.(1951-1953)cCc>cGc	p.P651R	DYSF_ENST00000409582.3_Missense_Mutation_p.P668R|DYSF_ENST00000410041.1_Missense_Mutation_p.P669R|DYSF_ENST00000409366.1_Missense_Mutation_p.P652R|DYSF_ENST00000409744.1_Missense_Mutation_p.P638R|DYSF_ENST00000410020.3_Missense_Mutation_p.P669R|DYSF_ENST00000394120.2_Missense_Mutation_p.P652R|DYSF_ENST00000409762.1_Missense_Mutation_p.P668R|DYSF_ENST00000409651.1_Missense_Mutation_p.P683R|DYSF_ENST00000413539.2_Missense_Mutation_p.P682R|DYSF_ENST00000429174.2_Missense_Mutation_p.P651R	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	651						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TACTACCTACCCTGGGGTAAC	0.597000													3	17					0	0	0.004672	0	0
REV3L	5980	broad.mit.edu	37	6	111696451	111696451	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:111696451G>T	ENST00000435970.1	-	15	3689	c.2873C>A	c.(2872-2874)cCc>cAc	p.P958H	REV3L_ENST00000358835.3_Missense_Mutation_p.P1036H|REV3L_ENST00000368802.3_Missense_Mutation_p.P1036H|REV3L_ENST00000368805.1_Missense_Mutation_p.P1036H			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1036					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TGGATAAATGGGATATTTGGT	0.333000								DNA polymerases (catalytic subunits)					22	136					7.92952e-12	8.28108e-12	0.003954	1	0
RASGRF2	5924	broad.mit.edu	37	5	80382693	80382693	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:80382693G>A	ENST00000265080.4	+	9	1378	c.1311G>A	c.(1309-1311)agG>agA	p.R437R	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	437					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AAAACATAAGGAAAAACCTTG	0.473000													7	39					0	0	0.001984	0	0
CDR1	1038	broad.mit.edu	37	X	139865858	139865858	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:139865858C>T	ENST00000370532.2	-	1	865	c.674G>A	c.(673-675)aGa>aAa	p.R225K		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	225										breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCAGAAAAATCTACGTCTTCC	0.438000													22	56					0	0	0.014323	0	0
ATXN7L3	56970	broad.mit.edu	37	17	42275002	42275002	+	Silent	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:42275002A>G	ENST00000389384.4	-	2	456	c.148T>C	c.(148-150)Ttg>Ctg	p.L50L	ATXN7L3_ENST00000454077.2_Silent_p.L50L|ATXN7L3_ENST00000593073.1_Intron	NM_001098833.1	NP_001092303.1	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3	50					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GTGTCGTCCAAGAAGAAGTAG	0.547000													20	118					0	0	0.012319	0	0
OSBPL3	26031	broad.mit.edu	37	7	24902884	24902884	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:24902884C>T	ENST00000313367.2	-	9	1256	c.805G>A	c.(805-807)Gaa>Aaa	p.E269K	OSBPL3_ENST00000396429.1_Missense_Mutation_p.E269K|OSBPL3_ENST00000409069.1_Intron|OSBPL3_ENST00000431825.2_Intron|OSBPL3_ENST00000353930.1_Missense_Mutation_p.E269K|OSBPL3_ENST00000352860.1_Intron|OSBPL3_ENST00000396431.1_Intron	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	269					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						GATCTTTTTTCCTTTTTGGGA	0.448000													14	73					0	0	0.004007	0	0
OR5H15	403274	broad.mit.edu	37	3	97888366	97888366	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:97888366C>G	ENST00000356526.2	+	1	823	c.823C>G	c.(823-825)Cct>Gct	p.P275A		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						TATGGTGGAGCCTCTATTCTA	0.393000													8	49					0	0	0.003080	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173832016	173832016	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:173832016A>G	ENST00000264111.6	+	10	1032	c.845A>G	c.(844-846)aAa>aGa	p.K282R	RAPGEF4_ENST00000539331.1_Missense_Mutation_p.K130R|RAPGEF4_ENST00000538974.1_Missense_Mutation_p.K112R|RAPGEF4_ENST00000535187.1_Missense_Mutation_p.K63R|RAPGEF4_ENST00000473043.1_3'UTR|RAPGEF4_ENST00000409036.1_Missense_Mutation_p.K283R|RAPGEF4_ENST00000397081.3_Missense_Mutation_p.K283R|RAPGEF4_ENST00000397087.3_Missense_Mutation_p.K139R|RAPGEF4_ENST00000540783.1_Missense_Mutation_p.K130R			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	283	DEP.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TTCCAAGACAAATATTTATTC	0.498000													6	17					0	0	0.004482	0	0
OR4K2	390431	broad.mit.edu	37	14	20344762	20344762	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:20344762C>T	ENST00000298642.2	+	1	372	c.336C>T	c.(334-336)atC>atT	p.I112I		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GAACTGAGATCATCTTACTCA	0.438000													28	69					0	0	0.006320	0	0
TRPM3	80036	broad.mit.edu	37	9	73458035	73458035	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:73458035G>A	ENST00000377110.2	-	5	928	c.685C>T	c.(685-687)Cgt>Tgt	p.R229C	TRPM3_ENST00000408909.2_Missense_Mutation_p.R76C|TRPM3_ENST00000360823.2_Missense_Mutation_p.R76C|TRPM3_ENST00000377105.1_Missense_Mutation_p.R76C|TRPM3_ENST00000396285.1_Missense_Mutation_p.R76C|TRPM3_ENST00000377111.2_Missense_Mutation_p.R229C|TRPM3_ENST00000377106.1_Missense_Mutation_p.R76C|TRPM3_ENST00000396280.5_Missense_Mutation_p.R76C|TRPM3_ENST00000358082.3_Missense_Mutation_p.R76C|TRPM3_ENST00000377101.1_Missense_Mutation_p.R76C|TRPM3_ENST00000361823.5_Missense_Mutation_p.R76C|TRPM3_ENST00000396283.1_Missense_Mutation_p.R76C|TRPM3_ENST00000377097.3_Missense_Mutation_p.R76C|TRPM3_ENST00000357533.2_Missense_Mutation_p.R231C|TRPM3_ENST00000423814.3_Missense_Mutation_p.R231C|TRPM3_ENST00000396292.4_Missense_Mutation_p.R76C	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	229						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						CCAACATGACGAATAACACCT	0.403000													4	21					0	0	0.000602	0	0
SLC26A4	5172	broad.mit.edu	37	7	107334926	107334926	+	Splice_Site	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:107334926G>T	ENST00000265715.3	+	11	1565		c.e11+1		SLC26A4_ENST00000480841.1_Splice_Site|SLC26A4_ENST00000543100.1_Splice_Site|SLC26A4_ENST00000544569.1_Splice_Site|SLC26A4_ENST00000541474.1_Intron	NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4						regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						CTTGCAGAAGGTATAACCCTG	0.458000									Pendred syndrome				12	57					4.3838e-07	4.5468e-07	0.001855	1	0
CACNA1A	773	broad.mit.edu	37	19	13386753	13386753	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:13386753G>A	ENST00000360228.5	-	24	3899	c.3900C>T	c.(3898-3900)ctC>ctT	p.L1300L	CACNA1A_ENST00000573710.2_Silent_p.L1301L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1301					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GATGCAGGACGAGCCCCAGGT	0.592000													6	24					0	0	0.001984	0	0
C2orf80	389073	broad.mit.edu	37	2	209051686	209051686	+	Missense_Mutation	SNP	C	C	T	rs138681111		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:209051686C>T	ENST00000341287.4	-	2	220	c.25G>A	c.(25-27)Gaa>Aaa	p.E9K	C2orf80_ENST00000453017.1_Missense_Mutation_p.E9K|C2orf80_ENST00000451346.1_Intron	NM_001099334.2	NP_001092804.1	Q0P641	CB080_HUMAN	chromosome 2 open reading frame 80	9								p.E9K(1)		endometrium(2)|large_intestine(3)|lung(6)|skin(2)	13						TTTTTCATTTCCTTCTTTATG	0.423000													8	29					0	0	0.003080	0	0
AFF3	3899	broad.mit.edu	37	2	100209733	100209733	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:100209733G>A	ENST00000317233.4	-	14	2625	c.2390C>T	c.(2389-2391)tCt>tTt	p.S797F	AFF3_ENST00000409579.1_Missense_Mutation_p.S822F|AFF3_ENST00000356421.2_Missense_Mutation_p.S822F|AFF3_ENST00000409236.1_Missense_Mutation_p.S797F	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	797					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TGCGCTCTCAGAGTCCTTGGT	0.607000													17	62					0	0	0.006122	0	0
FGD2	221472	broad.mit.edu	37	6	36976721	36976721	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:36976721C>T	ENST00000274963.8	+	2	351	c.180C>T	c.(178-180)gcC>gcT	p.A60A		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	60					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						TCGGGGAGGCCGTGGGGTCTG	0.632000													9	86					0	0	0.004482	0	0
BNC1	646	broad.mit.edu	37	15	83935648	83935648	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:83935648G>A	ENST00000345382.2	-	3	460	c.375C>T	c.(373-375)ctC>ctT	p.L125L	BNC1_ENST00000569704.1_Silent_p.L118L|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	125					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						GGAGGATCTGGAGAACCTCAT	0.493000													19	97					0	0	0.008871	0	0
GRWD1	83743	broad.mit.edu	37	19	48954323	48954323	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:48954323C>T	ENST00000253237.5	+	6	1091	c.858C>T	c.(856-858)atC>atT	p.I286I		NM_031485.3	NP_113673.3	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	286						nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|stomach(1)	19		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		ACGCCTCCATCCGCATCTGGG	0.672000													15	61					0	0	0.006122	0	0
FAR2P1	440905	broad.mit.edu	37	2	130792830	130792830	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:130792830C>T	ENST00000325390.3	-	0	2498					NR_026758.1																						GAAACCCTTTCCCAGCCTGCA	0.418000													5	13					0	0	0.000602	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227239590	227239590	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:227239590G>A	ENST00000366766.2	-	22	3943	c.3001C>T	c.(3001-3003)Cca>Tca	p.P1001S	CDC42BPA_ENST00000366764.2_Intron|CDC42BPA_ENST00000535525.1_Intron|CDC42BPA_ENST00000366769.3_Intron|CDC42BPA_ENST00000366767.3_Intron|CDC42BPA_ENST00000334218.5_Intron|CDC42BPA_ENST00000366765.3_Intron			Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	979					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				ACCTTAACTGGCTCAGCTTCA	0.463000													9	60					0	0	0.008291	0	0
RNF152	220441	broad.mit.edu	37	18	59483693	59483693	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:59483693C>T	ENST00000312828.3	-	2	1103	c.4G>A	c.(4-6)Gag>Aag	p.E2K		NM_173557.2	NP_775828.1	Q8N8N0	RN152_HUMAN	ring finger protein 152	2					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)	17		Colorectal(73;0.186)				GACAGCGTCTCCATGGTGGAC	0.587000													15	85					0	0	0.004990	0	0
SIGLECL1	284369	broad.mit.edu	37	19	51771825	51771825	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:51771825G>A	ENST00000316401.7	+	6	949	c.567_splice	c.e6-1	p.E190_splice	SIGLECL1_ENST00000597824.1_Splice_Site_p.E96_splice|CTD-3187F8.2_ENST00000597569.1_RNA|SIGLECL1_ENST00000593968.1_3'UTR	NM_173635.1	NP_775906.1			SIGLEC family like 1																		TCGCTTTCAGGAAAAGCAAGA	0.428000													7	44					0	0	0.006214	0	0
HYDIN	54768	broad.mit.edu	37	16	70908731	70908731	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:70908731G>A	ENST00000393567.2	-	63	10799	c.10649C>T	c.(10648-10650)cCa>cTa	p.P3550L		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3550										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TTTTACATGTGGTTTATTTTC	0.522000													7	16					0	0	0.003080	0	0
ARSK	153642	broad.mit.edu	37	5	94918630	94918630	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:94918630G>A	ENST00000380009.4	+	4	632	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K		NM_198150.2	NP_937793.1	Q6UWY0	ARSK_HUMAN	arylsulfatase family, member K	143						extracellular region	arylsulfatase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(1)	16		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		TAATCGTGTGGAAGCGTGGAC	0.383000													22	95					0	0	0.004656	0	0
MTFR2	113115	broad.mit.edu	37	6	136552438	136552438	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:136552438G>A	ENST00000420702.1	-	8	1522	c.1133C>T	c.(1132-1134)aCa>aTa	p.T378I	MTFR2_ENST00000451457.2_Missense_Mutation_p.T378I	NM_001099286.1	NP_001092756.1			mitochondrial fission regulator 2																		TAGAAGGCTTGTGTTGCTGAT	0.363000													4	21					0	0	0.000602	0	0
RGR	5995	broad.mit.edu	37	10	86017672	86017672	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:86017672G>A	ENST00000359452.4	+	6	704	c.666G>A	c.(664-666)agG>agA	p.R222R	RGR_ENST00000479725.1_3'UTR|RGR_ENST00000358110.5_Intron	NM_001012720.1|NM_002921.3	NP_001012738.1|NP_002912.2	P47804	RGR_HUMAN	retinal G protein coupled receptor	218					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	17						TGCCAGCAAGGACGCTGCTGC	0.557000													7	45					0	0	0.006214	0	0
DOCK2	1794	broad.mit.edu	37	5	169410162	169410162	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:169410162G>A	ENST00000256935.8	+	28	2970	c.2890G>A	c.(2890-2892)Gaa>Aaa	p.E964K	DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Missense_Mutation_p.E25K|DOCK2_ENST00000520908.1_Missense_Mutation_p.E456K	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	964	Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GACCAGCTCTGAACTTGTGGT	0.502000													27	89					0	0	0.006320	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373763	86373763	+	Silent	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:86373763A>G	ENST00000604798.1	-	8	1945	c.741T>C	c.(739-741)acT>acC	p.T247T	MGAT4C_ENST00000393205.2_Silent_p.T276T|MGAT4C_ENST00000548651.1_Silent_p.T247T|MGAT4C_ENST00000552808.2_Silent_p.T247T|MGAT4C_ENST00000552435.2_Intron|MGAT4C_ENST00000332156.1_Silent_p.T247T|MGAT4C_ENST00000549405.2_Silent_p.T247T			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	247					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						TTACCCAGTAAGTTCCTTCTA	0.353000													6	35					0	0	0.001168	0	0
ZBTB18	10472	broad.mit.edu	37	1	244217203	244217203	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:244217203C>T	ENST00000358704.4	+	2	276	c.127C>T	c.(127-129)Cag>Tag	p.Q43*		NM_001278196.1|NM_006352.4|NM_205768.2	NP_001265125.1|NP_006343.2|NP_991331.1			zinc finger and BTB domain containing 18																		GGGAGATGCCCAGTTCCGAGC	0.488000													16	57					0	0	0.004007	0	0
NDNF	79625	broad.mit.edu	37	4	121957872	121957872	+	Silent	SNP	G	G	A	rs148977529	byFrequency	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:121957872G>A	ENST00000379692.4	-	4	1780	c.1254C>T	c.(1252-1254)ctC>ctT	p.L418L		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	418										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						TCAGTCGAACGAGGTATTTAG	0.418000													30	90					0	0	0.008361	0	0
IFT172	26160	broad.mit.edu	37	2	27676582	27676582	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:27676582G>T	ENST00000260570.3	-	34	3839	c.3736C>A	c.(3736-3738)Ctg>Atg	p.L1246M		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1246					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					CAGATGCGCAGAGCGTCACTC	0.582000													14	47					3.99206e-14	4.17728e-14	0.007413	1	0
FANCD2	2177	broad.mit.edu	37	3	10130618	10130618	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:10130618T>C	ENST00000287647.3	+	36	3760	c.3667T>C	c.(3667-3669)Ttc>Ctc	p.F1223L	FANCD2_ENST00000419585.1_Missense_Mutation_p.F1223L|FANCD2OS_ENST00000436517.1_Intron|FANCD2_ENST00000383806.1_Missense_Mutation_p.F1223L|FANCD2OS_ENST00000524279.1_Intron|FANCD2_ENST00000383807.1_Missense_Mutation_p.F1223L	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1223					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TTCCTCCACATTCCCTACACT	0.498000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				18	92					0	0	0.006122	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004814	75004814	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:75004814C>T	ENST00000373359.2	-	1	265	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	25										autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GCTTGTATTTCACCTCTGCCG	0.577000													10	17					0	0	0.006214	0	0
ITIH5	80760	broad.mit.edu	37	10	7615118	7615118	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:7615118G>A	ENST00000256861.6	-	11	2097	c.2019C>T	c.(2017-2019)atC>atT	p.I673I	ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000446830.2_Silent_p.I455I|ITIH5_ENST00000298441.6_Silent_p.I459I|ITIH5_ENST00000397146.2_Intron|ITIH5_ENST00000397145.2_Silent_p.I673I	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	673					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						ATGTTTTAGAGATTTTAATTC	0.423000													7	21					0	0	0.001984	0	0
TIMM17A	10440	broad.mit.edu	37	1	201924657	201924657	+	Translation_Start_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:201924657G>A	ENST00000367287.4	+	1	39	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_006335.2	NP_006326.1	Q99595	TI17A_HUMAN	translocase of inner mitochondrial membrane 17 homolog A (yeast)	1					protein targeting to mitochondrion	integral to membrane|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			kidney(1)|lung(3)|stomach(1)	5						GAGTCAAGATGGAGGAGTACG	0.617000													16	53					0	0	0.004990	0	0
HFE2	148738	broad.mit.edu	37	1	145416872	145416872	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:145416872C>T	ENST00000336751.5	+	4	1455	c.1217C>T	c.(1216-1218)tCc>tTc	p.S406F	HFE2_ENST00000357836.5_Missense_Mutation_p.S293F|HFE2_ENST00000475797.1_Missense_Mutation_p.S180F|HFE2_ENST00000497365.1_Missense_Mutation_p.S180F	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	406					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GTTCCTCTTTCCTCAGCAACC	0.522000													14	99					0	0	0.001855	0	0
WDR60	55112	broad.mit.edu	37	7	158663875	158663875	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:158663875G>A	ENST00000407559.3	+	3	270	c.112G>A	c.(112-114)Gag>Aag	p.E38K		NM_018051.4	NP_060521.4	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	38										NS(3)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(4)|lung(16)|ovary(2)	35	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		AAAGCACAGAGAGAAGAAGCT	0.527000													22	45					0	0	0.014323	0	0
GRID2	2895	broad.mit.edu	37	4	94436427	94436427	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:94436427G>A	ENST00000282020.4	+	13	2316	c.2058G>A	c.(2056-2058)gcG>gcA	p.A686A	GRID2_ENST00000510992.1_Silent_p.A591A	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	686					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TAGACTCTGCGGTATATGAGC	0.468000													7	35					0	0	0.003080	0	0
SIN3A	25942	broad.mit.edu	37	15	75684670	75684670	+	Missense_Mutation	SNP	G	G	C	rs150346677		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:75684670G>C	ENST00000394947.3	-	15	3078	c.2764C>G	c.(2764-2766)Cga>Gga	p.R922G	SIN3A_ENST00000360439.4_Missense_Mutation_p.R922G|SIN3A_ENST00000394949.4_Missense_Mutation_p.R922G	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	922					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						TCTCTCTCTCGGTTTTCTTCT	0.493000													21	123					0	0	0.003330	0	0
KIAA1328	57536	broad.mit.edu	37	18	34647216	34647216	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:34647216C>T	ENST00000591619.1	+	7	1714	c.928C>T	c.(928-930)Cgt>Tgt	p.R310C	KIAA1328_ENST00000435985.2_Missense_Mutation_p.R30C|KIAA1328_ENST00000543923.1_Missense_Mutation_p.R206C|KIAA1328_ENST00000280020.5_Missense_Mutation_p.R314C|KIAA1328_ENST00000586135.1_Missense_Mutation_p.R30C|KIAA1328_ENST00000586501.1_Missense_Mutation_p.R30C			Q86T90	K1328_HUMAN	KIAA1328	314										central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	14				COAD - Colon adenocarcinoma(74;0.195)		TGCTGCAGATCGTGTTCATGA	0.458000													7	53					0	0	0.001984	0	0
PTPRB	5787	broad.mit.edu	37	12	70946612	70946612	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:70946612C>T	ENST00000334414.6	-	21	5376	c.5332G>A	c.(5332-5334)Gat>Aat	p.D1778N	PTPRB_ENST00000550857.1_Missense_Mutation_p.D1470N|PTPRB_ENST00000550358.1_Missense_Mutation_p.D1690N|PTPRB_ENST00000538708.1_Missense_Mutation_p.D1470N|PTPRB_ENST00000451516.2_Missense_Mutation_p.D1470N|PTPRB_ENST00000261266.5_Missense_Mutation_p.D1560N	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1560	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGAGTGGGATCGCATTTTCCA	0.423000													15	37					0	0	0.004007	0	0
PNMA2	10687	broad.mit.edu	37	8	26366158	26366158	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:26366158G>A	ENST00000522362.2	-	3	1008	c.114C>T	c.(112-114)gtC>gtT	p.V38V		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	38					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		tctcctgaaggacctcctgaa	0.498000													18	80					0	0	0.007413	0	0
EPHX4	253152	broad.mit.edu	37	1	92498096	92498096	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:92498096G>A	ENST00000370383.4	+	2	364	c.266G>A	c.(265-267)gGa>gAa	p.G89E		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	89						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						GTTGCTGCTGGAGAAAGAGGC	0.358000													15	67					0	0	0.007413	0	0
DCDC1	341019	broad.mit.edu	37	11	30953326	30953326	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:30953326C>T	ENST00000597505.1	-	20	2888	c.2889G>A	c.(2887-2889)cgG>cgA	p.R963R	DCDC1_ENST00000339794.5_Silent_p.R42R|DCDC1_ENST00000437348.1_5'UTR|DCDC1_ENST00000406071.2_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	199					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					ACTGCGTTTTCCGTCCAGGTG	0.383000													6	32					0	0	0.003080	0	0
SYNPO2	171024	broad.mit.edu	37	4	119948278	119948278	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:119948278C>T	ENST00000307142.4	+	3	950	c.754C>T	c.(754-756)Cct>Tct	p.P252S	SYNPO2_ENST00000434046.2_Missense_Mutation_p.P252S|SYNPO2_ENST00000429713.2_Missense_Mutation_p.P252S|SYNPO2_ENST00000448416.2_Intron	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	252						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GAAAGCAGACCCTTTCCTGAG	0.507000													4	44					0	0	0.009096	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58258011	58258011	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:58258011G>A	ENST00000249750.4	-	8	1580	c.813C>T	c.(811-813)atC>atT	p.I271I	ALDH1A2_ENST00000558231.1_Silent_p.I242I|ALDH1A2_ENST00000559517.1_Silent_p.I175I|ALDH1A2_ENST00000347587.3_Silent_p.I233I|ALDH1A2_ENST00000537372.1_Silent_p.I250I	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	271					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CTGCTTCTTGGATAAGCTTTC	0.443000													7	41					0	0	0.001984	0	0
SLC22A13	9390	broad.mit.edu	37	3	38307648	38307648	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:38307648C>T	ENST00000311856.4	+	1	346	c.297C>T	c.(295-297)ctC>ctT	p.L99L	SLC22A13_ENST00000450935.2_Silent_p.L58L	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	99						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		AGGACATCCTCAGCCACCGCT	0.587000													8	34					0	0	0.003080	0	0
NDUFA13	51079	broad.mit.edu	37	19	19626945	19626945	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:19626945C>T	ENST00000252576.5	+	1	147	c.147C>T	c.(145-147)ttC>ttT	p.F49F	NDUFA13_ENST00000507754.3_5'UTR	NM_015965.6	NP_057049.5			NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	12						TCCGGGACTTCCTAGCCGTGC	0.627000													6	36					0	0	0.001984	0	0
SLAIN1	122060	broad.mit.edu	37	13	78320899	78320899	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:78320899C>T	ENST00000466548.1	+	5	1127	c.1101C>T	c.(1099-1101)tcC>tcT	p.S367S	SLAIN1_ENST00000351546.3_Silent_p.S104S|SLAIN1_ENST00000465831.1_3'UTR|SLAIN1_ENST00000418532.1_Silent_p.S148S|SLAIN1_ENST00000488699.1_Silent_p.S225S|SLAIN1_ENST00000358679.3_Silent_p.S104S|SLAIN1_ENST00000267219.8_Silent_p.S148S|SLAIN1_ENST00000314070.5_Intron	NM_001242868.1	NP_001229797.1	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1	367										breast(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)		GCCCCAGTTCCCAGTATTTTC	0.473000													36	78					0	0	0.005524	0	0
RORC	6097	broad.mit.edu	37	1	151787500	151787500	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:151787500C>T	ENST00000356728.6	-	4	791	c.637G>A	c.(637-639)Gag>Aag	p.E213K	RORC_ENST00000318247.6_Missense_Mutation_p.E234K|RORC_ENST00000392697.3_Missense_Mutation_p.E288K	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	234	Hinge (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTGTGTTCCTCAAAACGAAGT	0.617000													8	34					0	0	0.003080	0	0
IZUMO2	126123	broad.mit.edu	37	19	50657857	50657857	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:50657857G>A	ENST00000293405.3	-	6	623	c.623_splice	c.e6+1	p.S208_splice		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	208						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						GATGACTCACGAGACCACGAT	0.567000													7	37					0	0	0.001984	0	0
GFRA3	2676	broad.mit.edu	37	5	137600092	137600092	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:137600092C>T	ENST00000274721.3	-	2	483	c.237G>A	c.(235-237)gaG>gaA	p.E79E	GFRA3_ENST00000378362.3_Silent_p.E79E	NM_001496.3	NP_001487.2	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3	79					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GGACCGAAGGCTCCTCTGAGG	0.607000													18	24					0	0	0.008871	0	0
CELSR3	1951	broad.mit.edu	37	3	48677785	48677785	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:48677785C>T	ENST00000544264.1	-	35	9528	c.9248G>A	c.(9247-9249)cGg>cAg	p.R3083Q	CELSR3_ENST00000164024.4_Missense_Mutation_p.R3078Q			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	3078					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTCAGTTGCCGCCGGAGGAG	0.647000													20	127					0	0	0.007413	0	0
OR4K17	390436	broad.mit.edu	37	14	20586023	20586023	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:20586023G>A	ENST00000315543.4	+	1	458	c.458G>A	c.(457-459)aGa>aAa	p.R153K		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GCTTTTGACAGATATGTGGCC	0.448000													11	71					0	0	0.010729	0	0
COL12A1	1303	broad.mit.edu	37	6	75858121	75858121	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:75858121G>A	ENST00000322507.8	-	22	4549	c.4240C>T	c.(4240-4242)Cga>Tga	p.R1414*	COL12A1_ENST00000345356.6_Nonsense_Mutation_p.R250*|COL12A1_ENST00000416123.2_Nonsense_Mutation_p.R1414*|COL12A1_ENST00000483888.2_Nonsense_Mutation_p.R1414*	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1414	Fibronectin type-III 9.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						ACCTTATATCGATCCACACTG	0.433000													9	45					0	0	0.006214	0	0
NBEA	26960	broad.mit.edu	37	13	35758160	35758160	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:35758160C>T	ENST00000540320.1	+	30	5413	c.4879C>T	c.(4879-4881)Ctt>Ttt	p.L1627F	NBEA_ENST00000310336.4_Missense_Mutation_p.L1627F|NBEA_ENST00000400445.3_Missense_Mutation_p.L1627F|NBEA_ENST00000379939.2_Missense_Mutation_p.L1624F			Q8NFP9	NBEA_HUMAN	neurobeachin	1627						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CCATGGATTCCTTGCCAAGTT	0.413000													7	41					0	0	0.004482	0	0
C1S	716	broad.mit.edu	37	12	7177170	7177170	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:7177170C>T	ENST00000406697.1	+	15	1910	c.1282C>T	c.(1282-1284)Ccc>Tcc	p.P428S	C1S_ENST00000495061.1_3'UTR|C1S_ENST00000402681.3_Missense_Mutation_p.P261S|C1S_ENST00000360817.5_Missense_Mutation_p.P428S|C1S_ENST00000328916.3_Missense_Mutation_p.P428S			P09871	C1S_HUMAN	complement component 1, s subcomponent	428					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	CTGTGGAGTCCCCAGAGAACC	0.458000													21	67					0	0	0.003330	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156634625	156634625	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:156634625G>A	ENST00000296518.7	+	7	1671	c.1462G>A	c.(1462-1464)Gtt>Att	p.V488I	GUCY1A3_ENST00000393832.3_Missense_Mutation_p.V230I|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.V488I|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.V488I|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.V488I|GUCY1A3_ENST00000511108.1_Missense_Mutation_p.V488I|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.V488I			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	488	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CTCAGACATCGTTGGGTTCAC	0.537000													11	52					0	0	0.013537	0	0
ZMYM6	9204	broad.mit.edu	37	1	35476593	35476593	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:35476593G>A	ENST00000357182.4	-	9	1334	c.1107C>T	c.(1105-1107)ccC>ccT	p.P369P	ZMYM6_ENST00000493328.1_5'UTR|ZMYM6_ENST00000373340.2_Silent_p.P369P|ZMYM6_ENST00000487874.1_Silent_p.P369P	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	369					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				CCTGAGACAGGGGCACCGCCG	0.473000													12	48					0	0	0.013537	0	0
LRP1B	53353	broad.mit.edu	37	2	141777573	141777573	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:141777573C>T	ENST00000389484.3	-	12	2859	c.1888G>A	c.(1888-1890)Gaa>Aaa	p.E630K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	630					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAAGCTTTTTCCAGCCTGGCC	0.428000										TSP Lung(27;0.18)			11	74					0	0	0.008291	0	0
TTC12	54970	broad.mit.edu	37	11	113222857	113222857	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:113222857C>T	ENST00000393020.1	+	16	1779	c.1374C>T	c.(1372-1374)ctC>ctT	p.L458L	TTC12_ENST00000529221.1_Silent_p.L458L|TTC12_ENST00000483239.2_Silent_p.L464L|TTC12_ENST00000478125.1_3'UTR|TTC12_ENST00000314756.3_Silent_p.L458L			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	458							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TGGGAAACCTCAGTGCTGAGC	0.512000													11	38					0	0	0.010729	0	0
MDN1	23195	broad.mit.edu	37	6	90397082	90397082	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:90397082A>G	ENST00000369393.3	-	68	11546	c.11431T>C	c.(11431-11433)Tgg>Cgg	p.W3811R	MDN1_ENST00000428876.1_Missense_Mutation_p.W3811R			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	3811					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGTTTACGCCACCGAATGATC	0.378000													6	47					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9065721	9065721	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9065721G>A	ENST00000397910.4	-	3	21928	c.21725C>T	c.(21724-21726)tCc>tTc	p.S7242F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7244	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCTCAGGGAGGAAATTGACTC	0.468000													29	143					0	0	0.009535	0	0
CCL14	6358	broad.mit.edu	37	17	34311406	34311406	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:34311406C>T	ENST00000480944.2	-	1	2634	c.228G>A	c.(226-228)gaG>gaA	p.E76E	CCL14_ENST00000394509.4_Silent_p.E54E|CCL14_ENST00000435911.2_Silent_p.E70E|CCL14_ENST00000536149.1_Silent_p.E70E|CCL15-CCL14_ENST00000481427.2_3'UTR|CCL14_ENST00000586216.1_Silent_p.E54E|CTB-186H2.3_ENST00000593057.1_Intron			Q16627	CCL14_HUMAN	chemokine (C-C motif) ligand 14	54					cellular calcium ion homeostasis|immune response|positive regulation of cell proliferation	extracellular space	chemokine activity|signal transducer activity			large_intestine(1)|lung(6)	7		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGCTGTTGGTCTCATAGTAAT	0.577000													20	102					0	0	0.014323	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767784	77767784	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:77767784A>G	ENST00000521891.2	+	10	9075	c.8627A>G	c.(8626-8628)aAt>aGt	p.N2876S	ZFHX4_ENST00000518282.1_Missense_Mutation_p.N2850S|ZFHX4_ENST00000455469.2_Missense_Mutation_p.N2831S|ZFHX4_ENST00000050961.6_Missense_Mutation_p.N2831S	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2831						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATCCATTTCAATGACAAAGAT	0.512000										HNSCC(33;0.089)			9	34					0	0	0.010729	0	0
TIAM2	26230	broad.mit.edu	37	6	155561752	155561752	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:155561752C>T	ENST00000461783.3	+	18	4530	c.3257C>T	c.(3256-3258)cCt>cTt	p.P1086L	TIAM2_ENST00000367174.2_Missense_Mutation_p.P462L|TIAM2_ENST00000529824.2_Missense_Mutation_p.P1086L|TIAM2_ENST00000275246.7_Missense_Mutation_p.P11L|TIAM2_ENST00000528391.2_Missense_Mutation_p.P422L|TIAM2_ENST00000456144.1_Missense_Mutation_p.P1086L|TIAM2_ENST00000360366.4_Missense_Mutation_p.P1110L|TIAM2_ENST00000456877.2_Missense_Mutation_p.P398L|TIAM2_ENST00000318981.5_Missense_Mutation_p.P1086L			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1086					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CAGGATCCTCCTCCGAGGTCT	0.572000													16	52					0	0	0.004007	0	0
ACSM4	341392	broad.mit.edu	37	12	7475053	7475053	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:7475053G>A	ENST00000399422.4	+	7	1089	c.1041G>A	c.(1039-1041)ggG>ggA	p.G347G		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	347					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						TGACCGGAGGGGAGCCACTCA	0.517000													7	39					0	0	0.003080	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41735146	41735146	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:41735146C>T	ENST00000352645.4	+	9	1024	c.767C>T	c.(766-768)tCa>tTa	p.S256L	ZC3H7B_ENST00000351589.4_Missense_Mutation_p.S256L	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	272					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding	p.S256*(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						GATGACTTCTCAGACGGGGAT	0.657000													11	58					0	0	0.008291	0	0
CPNE2	221184	broad.mit.edu	37	16	57159813	57159813	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:57159813C>T	ENST00000535318.2	+	12	1330	c.969C>T	c.(967-969)gaC>gaT	p.D323D	CPNE2_ENST00000537605.1_Silent_p.D221D|CPNE2_ENST00000565874.1_Silent_p.D323D|CPNE2_ENST00000290776.8_Silent_p.D323D|CPNE2_ENST00000565951.1_3'UTR			Q96FN4	CPNE2_HUMAN	copine II	323	VWFA.									central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(5)	21		all_neural(199;0.224)				ATCCCCTCGACCCTTCCTCTT	0.542000													20	43					0	0	0.007413	0	0
HDGF	3068	broad.mit.edu	37	1	156714136	156714136	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:156714136G>A	ENST00000357325.5	-	4	622	c.308C>T	c.(307-309)tCc>tTc	p.S103F	HDGF_ENST00000465180.1_5'UTR|HDGF_ENST00000416666.2_Missense_Mutation_p.S71F|HDGF_ENST00000368206.5_Missense_Mutation_p.S119F|HDGF_ENST00000368209.5_Missense_Mutation_p.S96F|HDGF_ENST00000537739.1_Missense_Mutation_p.S103F	NM_004494.2	NP_004485.1	P51858	HDGF_HUMAN	hepatoma-derived growth factor	103					cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		CTTTTTCTGGGAGGACTGCAG	0.607000													85	251					0	0	0.014410	0	0
UBE4A	9354	broad.mit.edu	37	11	118239362	118239362	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:118239362C>T	ENST00000252108.3	+	3	269	c.138C>T	c.(136-138)agC>agT	p.S46S	UBE4A_ENST00000431736.2_Silent_p.S46S	NM_001204077.1|NM_004788.3	NP_001191006.1|NP_004779.2	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	46					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(7)|liver(2)|lung(14)|ovary(3)|prostate(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	56	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TCCCAGCTAGCCCAGATGACT	0.428000													43	243					0	0	0.013114	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147183040	147183040	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:147183040C>T	ENST00000361727.3	+	11	2200	c.1684C>T	c.(1684-1686)Cac>Tac	p.H562Y		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	562	EGF-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGTGCCCAATCACTGTGAGCA	0.458000										HNSCC(39;0.1)			41	104					0	0	0.009718	0	0
CRTAC1	55118	broad.mit.edu	37	10	99696020	99696020	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:99696020G>A	ENST00000370597.3	-	3	683	c.328C>T	c.(328-330)Cgg>Tgg	p.R110W	CRTAC1_ENST00000370591.2_Missense_Mutation_p.R110W|CRTAC1_ENST00000298819.4_Missense_Mutation_p.R110W	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	110						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		TTCCCCTGCCGGTCCCGCAGC	0.622000													7	44					0	0	0.006214	0	0
CCDC86	79080	broad.mit.edu	37	11	60609774	60609774	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:60609774C>T	ENST00000227520.5	+	1	231	c.177C>T	c.(175-177)ccC>ccT	p.P59P	RP11-804A23.4_ENST00000538705.1_RNA|RP11-804A23.2_ENST00000539897.1_RNA	NM_024098.3	NP_077003.1	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	59	Pro-rich.				interspecies interaction between organisms	nucleus				endometrium(1)|large_intestine(2)|liver(2)|lung(2)|urinary_tract(3)	10						TGGGGTCCCCCGAAAGGCCGC	0.692000													10	46					0	0	0.008291	0	0
FYN	2534	broad.mit.edu	37	6	112035566	112035566	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:112035566G>A	ENST00000354650.3	-	5	934	c.328C>T	c.(328-330)Caa>Taa	p.Q110*	FYN_ENST00000356013.2_Nonsense_Mutation_p.Q110*|FYN_ENST00000368667.2_Nonsense_Mutation_p.Q110*|FYN_ENST00000368682.3_Nonsense_Mutation_p.Q110*|FYN_ENST00000538466.1_Nonsense_Mutation_p.Q110*|FYN_ENST00000229470.5_Intron|FYN_ENST00000229471.4_Nonsense_Mutation_p.Q110*|FYN_ENST00000368678.4_Nonsense_Mutation_p.Q110*	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	110	SH3.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTCAATATTTGAAATTTTTCT	0.438000													8	41					0	0	0.006214	0	0
DCTN1	1639	broad.mit.edu	37	2	74593086	74593086	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:74593086G>A	ENST00000361874.3	-	24	3137	c.2820C>T	c.(2818-2820)ggC>ggT	p.G940G	DCTN1_ENST00000409438.1_Silent_p.G806G|DCTN1_ENST00000409868.1_Silent_p.G923G|DCTN1_ENST00000407639.2_Silent_p.G806G|DCTN1_ENST00000394003.3_Silent_p.G933G|DCTN1_ENST00000409240.1_Silent_p.G903G|DCTN1_ENST00000409567.3_Silent_p.G920G	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	940					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						TCAAACCCAGGCCTTCAGCAT	0.537000													25	89					0	0	0.004656	0	0
DNAH9	1770	broad.mit.edu	37	17	11642268	11642268	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:11642268G>A	ENST00000262442.3	+	29	5954	c.5886G>A	c.(5884-5886)ctG>ctA	p.L1962L	DNAH9_ENST00000454412.2_Silent_p.L1962L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1962	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGATCAGCCTGAATCCTTCTG	0.478000													7	62					0	0	0.003080	0	0
EMC8	10328	broad.mit.edu	37	16	85832894	85832894	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:85832894C>T	ENST00000253457.3	-	1	252	c.8G>A	c.(7-9)gGg>gAg	p.G3E	EMC8_ENST00000435200.2_Missense_Mutation_p.G3E	NM_006067.4	NP_006058.1			ER membrane protein complex subunit 8																		CAGTTTCACCCCGGGCATGCT	0.726000													3	9					0	0	0.004672	0	0
PIWIL2	55124	broad.mit.edu	37	8	22140749	22140749	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:22140749G>A	ENST00000356766.6	+	5	776	c.628G>A	c.(628-630)Gaa>Aaa	p.E210K	PIWIL2_ENST00000521356.1_Missense_Mutation_p.E210K|PIWIL2_ENST00000454009.2_Missense_Mutation_p.E210K	NM_018068.3	NP_060538.2	Q8TC59	PIWL2_HUMAN	piwi-like RNA-mediated gene silencing 2	210					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		GGAACACAAGGAAAAGTAAGT	0.522000													7	31					0	0	0.001984	0	0
STYK1	55359	broad.mit.edu	37	12	10777432	10777432	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:10777432G>A	ENST00000075503.3	-	8	1264	c.744C>T	c.(742-744)ttC>ttT	p.F248F		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	248	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						CATCCCCATGGAACAAATGCT	0.478000										HNSCC(73;0.22)			19	103					0	0	0.012319	0	0
MYH2	4620	broad.mit.edu	37	17	10447086	10447086	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:10447086G>A	ENST00000245503.5	-	8	1067	c.683C>T	c.(682-684)cCc>cTc	p.P228L	MYH2_ENST00000397183.2_Missense_Mutation_p.P228L|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Missense_Mutation_p.P228L	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	228	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CTCCAGTAGGGGGTTGGCACT	0.522000													9	47					0	0	0.008291	0	0
KCNMA1	3778	broad.mit.edu	37	10	78870041	78870041	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:78870041C>T	ENST00000286627.5	-	8	1973	c.1021G>A	c.(1021-1023)Gaa>Aaa	p.E341K	KCNMA1_ENST00000404771.3_Missense_Mutation_p.E341K|KCNMA1_ENST00000354353.5_Missense_Mutation_p.E341K|KCNMA1_ENST00000372443.1_Missense_Mutation_p.E341K|KCNMA1_ENST00000372440.1_Missense_Mutation_p.E341K|KCNMA1_ENST00000286628.8_Missense_Mutation_p.E341K|KCNMA1_ENST00000404857.1_Missense_Mutation_p.E341K|KCNMA1_ENST00000406533.3_Missense_Mutation_p.E341K	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	341					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TAGACACATTCCCAGTAGGTG	0.453000													28	194					0	0	0.010818	0	0
SP110	3431	broad.mit.edu	37	2	231067390	231067390	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:231067390A>G	ENST00000258381.6	-	9	1030	c.953T>C	c.(952-954)gTt>gCt	p.V318A	SP110_ENST00000338556.3_Intron|SP110_ENST00000358662.4_Missense_Mutation_p.V318A|SP110_ENST00000540870.1_Missense_Mutation_p.V324A|SP110_ENST00000392048.3_Missense_Mutation_p.V316A|SP110_ENST00000258382.5_Missense_Mutation_p.V318A	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	318					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		CTTTTGAGGAACCTGATCCAC	0.453000													18	111					0	0	0.012319	0	0
CACNA1B	774	broad.mit.edu	37	9	140990947	140990947	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:140990947C>T	ENST00000277549.5	+	37	5257	c.2688C>T	c.(2686-2688)ctC>ctT	p.L896L	CACNA1B_ENST00000371357.1_Silent_p.L1701L|CACNA1B_ENST00000371365.2_Silent_p.L66L|CACNA1B_ENST00000277551.2_Silent_p.L1702L|CACNA1B_ENST00000371363.1_Silent_p.L1700L|CACNA1B_ENST00000371372.1_Silent_p.L1702L|CACNA1B_ENST00000371355.4_Silent_p.L1703L			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1702					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGTTGAACCTCTTTGTGGCTG	0.567000													17	80					0	0	0.007413	0	0
DCC	1630	broad.mit.edu	37	18	50278616	50278616	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:50278616G>C	ENST00000442544.2	+	2	900	c.284G>C	c.(283-285)gGg>gCg	p.G95A	DCC_ENST00000412726.1_5'UTR	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	95	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTTTCAAATGGGTCTCTGCTG	0.463000													11	93					0	0	0.013537	0	0
C9orf3	84909	broad.mit.edu	37	9	97718274	97718274	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:97718274C>T	ENST00000375315.2	+	8	1849	c.1849C>T	c.(1849-1851)Cat>Tat	p.H617Y	C9orf3_ENST00000297979.5_Missense_Mutation_p.H518Y	NM_001193329.1	NP_001180258.1	Q8N6M6	AMPO_HUMAN	chromosome 9 open reading frame 3	617					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		GCACACATTTCATGGACAGCT	0.393000													13	86					0	0	0.003163	0	0
STON1	11037	broad.mit.edu	37	2	48822421	48822421	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:48822421G>A	ENST00000309835.3	+	3	2198	c.2188G>A	c.(2188-2190)Ggt>Agt	p.G730S	STON1-GTF2A1L_ENST00000394754.1_Intron|STON1-GTF2A1L_ENST00000405008.1_Intron|STON1-GTF2A1L_ENST00000394751.3_Intron|STON1-GTF2A1L_ENST00000309827.2_Intron|STON1_ENST00000406226.1_Missense_Mutation_p.G730S|STON1_ENST00000404752.1_Missense_Mutation_p.G730S|STON1-GTF2A1L_ENST00000402114.2_Intron					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGATAAAATTGGTGACTGCAT	0.393000													5	13					0	0	0.001168	0	0
NAA11	84779	broad.mit.edu	37	4	80246900	80246900	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:80246900G>A	ENST00000286794.4	-	1	304	c.132C>T	c.(130-132)atC>atT	p.I44I		NM_032693.2	NP_116082.1	Q9BSU3	NAA11_HUMAN	N(alpha)-acetyltransferase 11, NatA catalytic subunit	44	Interaction with NAA15 (By similarity).|N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|skin(2)	23						CATCCTCAGCGATGTAAGAAA	0.488000													16	91					0	0	0.004990	0	0
MYH8	4626	broad.mit.edu	37	17	10300222	10300222	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:10300222C>T	ENST00000403437.2	-	31	4354	c.4260G>A	c.(4258-4260)acG>acA	p.T1420T	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1420					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GCCGCTGCTTCGTCTTCTCAA	0.488000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				13	56					0	0	0.003163	0	0
SYT1	6857	broad.mit.edu	37	12	79679661	79679661	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:79679661G>A	ENST00000261205.4	+	5	918	c.261G>A	c.(259-261)aaG>aaA	p.K87K	SYT1_ENST00000393240.3_Silent_p.K87K|SYT1_ENST00000552744.1_Silent_p.K87K|SYT1_ENST00000457153.2_Silent_p.K87K	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	87					detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						TGTTCAAAAAGAAAAACAAGA	0.388000													4	44					0	0	0.009096	0	0
AQP2	359	broad.mit.edu	37	12	50349325	50349325	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:50349325G>A	ENST00000199280.3	+	4	835	c.750G>A	c.(748-750)gaG>gaA	p.E250E	RP11-469H8.6_ENST00000550530.1_RNA|RP11-469H8.8_ENST00000552806.1_RNA|RP11-469H8.6_ENST00000552379.1_RNA	NM_000486.5	NP_000477.1	P41181	AQP2_HUMAN	aquaporin 2 (collecting duct)	250					cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(4)|ovary(2)	10						AGGAGCGCGAGGTGCGACGGC	0.697000													7	26					0	0	0.001984	0	0
ITGA7	3679	broad.mit.edu	37	12	56094741	56094741	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:56094741G>A	ENST00000257880.7	-	4	831	c.612C>T	c.(610-612)gcC>gcT	p.A204A	ITGA7_ENST00000394229.2_Silent_p.A204A|ITGA7_ENST00000452168.2_Silent_p.A107A|ITGA7_ENST00000257879.6_Silent_p.A204A|ITGA7_ENST00000347027.6_Silent_p.A204A|ITGA7_ENST00000394230.2_Silent_p.A204A|ITGA7_ENST00000553804.1_Silent_p.A204A|ITGA7_ENST00000555728.1_Silent_p.A204A			Q13683	ITA7_HUMAN	integrin, alpha 7	204					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CAGGGGAGAAGGCGGCAGCTG	0.582000													9	36					0	0	0.004482	0	0
CTNNA2	1496	broad.mit.edu	37	2	80874951	80874951	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:80874951C>T	ENST00000466387.1	+	22	3396	c.2672C>T	c.(2671-2673)tCg>tTg	p.S891L	CTNNA2_ENST00000541047.1_Missense_Mutation_p.S891L|CTNNA2_ENST00000402739.4_Missense_Mutation_p.S939L|CTNNA2_ENST00000540488.1_Missense_Mutation_p.S846L|CTNNA2_ENST00000361291.4_Missense_Mutation_p.S925L|CTNNA2_ENST00000496558.1_Missense_Mutation_p.S891L|CTNNA2_ENST00000343114.3_Missense_Mutation_p.S570L			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	939					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AAACACATTTCGCCTGTACAG	0.403000													14	122					0	0	0.001855	0	0
STARD4	134429	broad.mit.edu	37	5	110836762	110836762	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:110836762G>A	ENST00000296632.3	-	5	469	c.335C>T	c.(334-336)tCc>tTc	p.S112F	STARD4_ENST00000512160.1_Intron|STARD4_ENST00000509887.1_3'UTR|STARD4_ENST00000502322.1_Missense_Mutation_p.S112F|STARD4_ENST00000511569.1_5'UTR	NM_139164.1	NP_631903.1	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	112	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		TTCTCTTGGGGAAATTATATT	0.353000													20	107					0	0	0.012319	0	0
PPFIA1	8500	broad.mit.edu	37	11	70228206	70228206	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:70228206G>A	ENST00000253925.7	+	27	3778	c.3563G>A	c.(3562-3564)gGa>gAa	p.G1188E	AP000487.5_ENST00000500185.2_RNA|PPFIA1_ENST00000530548.1_3'UTR|AP000487.5_ENST00000530690.1_RNA|AP000487.5_ENST00000524619.1_RNA	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	1188					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			AATGTATCAGGAACACAGAGG	0.498000											OREG0021174	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	21					0	0	0.009096	0	0
MYH7	4625	broad.mit.edu	37	14	23890220	23890220	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:23890220C>T	ENST00000355349.3	-	26	3445	c.3283G>A	c.(3283-3285)Gag>Aag	p.E1095K		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1095					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGTTCATCCTCAATCCTTGCG	0.587000													15	77					0	0	0.007413	0	0
IKZF1	10320	broad.mit.edu	37	7	50468256	50468256	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:50468256C>T	ENST00000331340.3	+	8	1646	c.1491C>T	c.(1489-1491)taC>taT	p.Y497Y	IKZF1_ENST00000438033.1_Silent_p.Y410Y|IKZF1_ENST00000357364.4_Silent_p.Y410Y|IKZF1_ENST00000343574.5_Silent_p.Y410Y|IKZF1_ENST00000349824.4_Silent_p.Y354Y|IKZF1_ENST00000439701.1_Silent_p.Y455Y|IKZF1_ENST00000359197.5_Silent_p.Y455Y|IKZF1_ENST00000346667.4_Silent_p.Y267Y|IKZF1_ENST00000440768.2_3'UTR	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	497					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				TGTGCGGCTACCACAGCCAGG	0.617000			"""D,T"""	BCL6	"""ALL, DLBCL"""								5	28					0	0	0.001168	0	0
CNTN5	53942	broad.mit.edu	37	11	100061868	100061868	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:100061868C>T	ENST00000524871.1	+	14	1881	c.1591C>T	c.(1591-1593)Ctt>Ttt	p.L531F	CNTN5_ENST00000528682.1_Missense_Mutation_p.L531F|CNTN5_ENST00000527185.1_Missense_Mutation_p.L531F|CNTN5_ENST00000279463.3_Missense_Mutation_p.L531F|CNTN5_ENST00000418526.2_Missense_Mutation_p.L457F	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	531	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AATAGCTATTCTTCCAGACGG	0.363000													9	19					0	0	0.006214	0	0
CDH22	64405	broad.mit.edu	37	20	44828153	44828153	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:44828153G>A	ENST00000372262.3	-	7	1732	c.1332C>T	c.(1330-1332)atC>atT	p.I444I	CDH22_ENST00000537909.1_Silent_p.I444I	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	444	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				TGTCCGCATCGATATCGAAGA	0.632000													21	41					0	0	0.002780	0	0
TNXB	7148	broad.mit.edu	37	6	32021267	32021267	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:32021267C>T	ENST00000375244.3	-	25	8890	c.8689G>A	c.(8689-8691)Gtc>Atc	p.V2897I	TNXB_ENST00000375247.2_Missense_Mutation_p.V2895I			P22105	TENX_HUMAN	tenascin XB	2944	Fibronectin type-III 21.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GAGATGGTGACCCCGTCCTCG	0.637000													103	670					0	0	0.014410	0	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473333	22473333	+	RNA	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:22473333A>G	ENST00000557788.2	-	0	20																											CCAGGAGGAGAAAGAACCACA	0.512000													5	51					0	0	0.001168	0	0
CERS6	253782	broad.mit.edu	37	2	169622848	169622848	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:169622848C>T	ENST00000392687.4	+	10	1219	c.1019C>T	c.(1018-1020)cCt>cTt	p.P340L	CERS6_ENST00000305747.6_Intron	NM_001256126.1	NP_001243055.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	334						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										AAGTGGAACCCTTTACATGTA	0.463000													10	61					0	0	0.008291	0	0
PDYN	5173	broad.mit.edu	37	20	1961131	1961131	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:1961131C>T	ENST00000217305.2	-	4	828	c.603G>A	c.(601-603)gaG>gaA	p.E201E	PDYN_ENST00000540134.1_Silent_p.E201E|PDYN_ENST00000539905.1_Silent_p.E201E|RP4-684O24.5_ENST00000446562.1_RNA	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	201					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGTACAGGTCCTCATGGCCCA	0.592000													30	89					0	0	0.013726	0	0
NPVF	64111	broad.mit.edu	37	7	25266626	25266626	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:25266626C>T	ENST00000222674.2	-	2	204	c.158G>A	c.(157-159)gGg>gAg	p.G53E		NM_022150.3	NP_071433.3	Q9HCQ7	RFRP_HUMAN	neuropeptide VF precursor	53					neuropeptide signaling pathway	extracellular region|membrane	G-protein coupled receptor activity			cervix(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|urinary_tract(1)	15						GCTTCTTTCCCCTTTTGGGTA	0.353000													16	84					0	0	0.004990	0	0
CCDC28A	25901	broad.mit.edu	37	6	139094928	139094928	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:139094928G>A	ENST00000332797.6	+	1	272	c.117G>A	c.(115-117)agG>agA	p.R39R		NM_015439.2	NP_056254.1	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	39										autonomic_ganglia(1)|large_intestine(3)|lung(8)|ovary(1)	13				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		AGCTGCGGAGGAGCGGGTCCC	0.647000													50	261					0	0	0.014410	0	0
YTHDF1	54915	broad.mit.edu	37	20	61835041	61835041	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:61835041G>A	ENST00000370339.3	-	4	592	c.251C>T	c.(250-252)cCa>cTa	p.P84L	YTHDF1_ENST00000370334.4_Intron|YTHDF1_ENST00000370333.4_Missense_Mutation_p.P34L	NM_017798.3	NP_060268.2	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	84										NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)	24						GGTGAGGTATGGAATCGGAGG	0.547000													37	86					0	0	0.005524	0	0
SLC5A8	160728	broad.mit.edu	37	12	101603573	101603573	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:101603573G>A	ENST00000536262.2	-	1	612	c.54C>T	c.(52-54)ttC>ttT	p.F18F		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	18					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GCATGCCCGCGAACACCACGT	0.687000													6	37					0	0	0.001984	0	0
CYP4A11	1579	broad.mit.edu	37	1	47399628	47399628	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:47399628G>A	ENST00000310638.4	-	9	1243	c.1212C>T	c.(1210-1212)tcC>tcT	p.S404S	CYP4A11_ENST00000457840.2_3'UTR|CYP4A11_ENST00000371905.1_Silent_p.S404S|CYP4A11_ENST00000371904.4_Silent_p.S405S|CYP4A11_ENST00000475477.1_5'UTR	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	404					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	CTTTGGGCAAGGAGCGCCCAT	0.562000													8	44					0	0	0.006214	0	0
UGT2B28	54490	broad.mit.edu	37	4	70146345	70146345	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:70146345C>T	ENST00000335568.5	+	1	129	c.127C>T	c.(127-129)Ctg>Ttg	p.L43L	UGT2B28_ENST00000511240.1_Silent_p.L43L	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	43					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	GAAGACAATCCTGAAAGAGCT	0.448000													24	57					0	0	0.003954	0	0
ETV6	2120	broad.mit.edu	37	12	12022745	12022745	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:12022745C>T	ENST00000396373.4	+	5	1125	c.851C>T	c.(850-852)tCc>tTc	p.S284F		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	284						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CCCCGGCACTCCGTGGATTTC	0.612000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								11	53					0	0	0.010729	0	0
NOX3	50508	broad.mit.edu	37	6	155774610	155774610	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:155774610G>A	ENST00000159060.2	-	4	370	c.268C>T	c.(268-270)Ccg>Tcg	p.P90S		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	90	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CTCCTCCACGGTCCTCTGCAG	0.383000													32	185					0	0	0.005524	0	0
ORM1	5004	broad.mit.edu	37	9	117086350	117086350	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:117086350G>A	ENST00000259396.8	+	3	388	c.310G>A	c.(310-312)Ggg>Agg	p.G104R	ORM1_ENST00000538816.1_3'UTR|ORM1_ENST00000477456.1_3'UTR	NM_000607.2	NP_000598.2	P02763	A1AG1_HUMAN	orosomucoid 1	104					acute-phase response|regulation of immune system process|transport	extracellular space	protein binding			endometrium(2)|large_intestine(4)|lung(2)	8		Myeloproliferative disorder(63;0.163)			Acenocoumarol(DB01418)|Alfentanil(DB00802)|Aprindine(DB01429)|Disopyramide(DB00280)|Penbutolol(DB01359)|Phenprocoumon(DB00946)|Quinidine(DB00908)|Tamsulosin(DB00706)	GCGGGAAAATGGGACCATCTC	0.542000													14	65					0	0	0.003163	0	0
NR1H4	9971	broad.mit.edu	37	12	100904774	100904774	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:100904774G>A	ENST00000548884.1	+	4	839	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	NR1H4_ENST00000392986.3_Missense_Mutation_p.E100K|NR1H4_ENST00000188403.7_Missense_Mutation_p.E110K|NR1H4_ENST00000549996.1_Missense_Mutation_p.E100K|NR1H4_ENST00000551379.1_Missense_Mutation_p.E110K	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	110					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						CTACCAGGGAGAAACTGAGGT	0.527000													9	71					0	0	0.008291	0	0
ZAN	7455	broad.mit.edu	37	7	100355938	100355938	+	RNA	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:100355938G>A	ENST00000542585.1	+	0	3571				ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCCAGCTTAAGAATGGCCAGT	0.617000													20	54					0	0	0.008871	0	0
SACS	26278	broad.mit.edu	37	13	23913856	23913856	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:23913856G>A	ENST00000382298.3	-	10	4747	c.4159C>T	c.(4159-4161)Cct>Tct	p.P1387S	SACS_ENST00000402364.1_Missense_Mutation_p.P637S|SACS_ENST00000382292.3_Missense_Mutation_p.P1387S	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1387					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AGTTTAGAAGGATTTTTGCTA	0.353000													12	50					0	0	0.013537	0	0
SCAND3	114821	broad.mit.edu	37	6	28543880	28543880	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:28543880C>T	ENST00000452236.2	-	3	1219	c.602G>A	c.(601-603)aGc>aAc	p.S201N	SCAND3_ENST00000530247.1_5'UTR	NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	201					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ACCACCCATGCTTTGAGACAT	0.328000													4	37					0	0	0.000602	0	0
TNXB	7148	broad.mit.edu	37	6	32024618	32024618	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:32024618G>A	ENST00000375244.3	-	23	8089	c.7888C>T	c.(7888-7890)Cgc>Tgc	p.R2630C	TNXB_ENST00000375247.2_Missense_Mutation_p.R2630C			P22105	TENX_HUMAN	tenascin XB	2690	Fibronectin type-III 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TCCCCCAGGCGAGGCTTGATG	0.622000													202	1002					0	0	0.014410	0	0
DHRS7C	201140	broad.mit.edu	37	17	9684798	9684798	+	Splice_Site	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:9684798C>T	ENST00000330255.4	-	2	280		c.e2+1		DHRS7C_ENST00000571134.1_Splice_Site	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C							extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						GAAGACCTTACCTTGCTGGGG	0.542000													8	31					0	0	0.006214	0	0
ACOX1	51	broad.mit.edu	37	17	73945810	73945810	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:73945810G>A	ENST00000537812.1	-	10	2001	c.1353C>T	c.(1351-1353)ctC>ctT	p.L451L	ACOX1_ENST00000301608.4_Silent_p.L489L|ACOX1_ENST00000293217.5_Silent_p.L489L	NM_001185039.1	NP_001171968.1	Q15067	ACOX1_HUMAN	acyl-CoA oxidase 1, palmitoyl	489					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(1)	14						TGGCTGCACGGAGTTTATATG	0.557000													13	58					0	0	0.004007	0	0
OR13C2	392376	broad.mit.edu	37	9	107367196	107367196	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:107367196G>A	ENST00000542196.1	-	1	755	c.713C>T	c.(712-714)tCc>tTc	p.S238F		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						ACAGGTAGAGGAAGCTTTGCT	0.398000													14	69					0	0	0.004007	0	0
ICK	22858	broad.mit.edu	37	6	52878638	52878638	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:52878638G>A	ENST00000356971.3	-	10	1463	c.974C>T	c.(973-975)cCa>cTa	p.P325L	ICK_ENST00000350082.5_Missense_Mutation_p.P325L	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	325					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					CTTGGCTGGTGGCTGGGCAGG	0.537000													11	59					0	0	0.013537	0	0
MUC3A	4584	broad.mit.edu	37	7	100551488	100551488	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:100551488C>T	ENST00000319509.7	+	1	239	c.239C>T	c.(238-240)tCa>tTa	p.S80L						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						CACATCATTTCATCTTCTCCC	0.483000													23	157					0	0	0.014323	0	0
OR1F1	4992	broad.mit.edu	37	16	3254744	3254744	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:3254744C>T	ENST00000304646.2	+	1	498	c.498C>T	c.(496-498)ctC>ctT	p.L166L	AJ003147.9_ENST00000576468.1_RNA	NM_012360.1	NP_036492.1	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F, member 1	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(7)	11						TGGCTCCACTCTCATTCTGTG	0.517000													19	80					0	0	0.006122	0	0
IMPG1	3617	broad.mit.edu	37	6	76751792	76751792	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:76751792G>T	ENST00000369950.3	-	2	308	c.119C>A	c.(118-120)cCa>cAa	p.P40Q	IMPG1_ENST00000369963.3_Intron	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	40					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTCATTTCTTGGGGGATTGTC	0.313000													13	100					1.05317e-09	1.09555e-09	0.002450	1	0
NT5C1B	93034	broad.mit.edu	37	2	18766041	18766041	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:18766041C>T	ENST00000304081.4	-	4	562	c.462G>A	c.(460-462)gaG>gaA	p.E154E	NT5C1B-RDH14_ENST00000532967.1_Silent_p.E214E|NT5C1B_ENST00000600945.1_Silent_p.E214E|NT5C1B_ENST00000359846.2_Silent_p.E214E	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GGGCCCAGGCCTCCGGATTCT	0.697000													6	43					0	0	0.001984	0	0
PLXNB1	5364	broad.mit.edu	37	3	48454244	48454244	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:48454244C>T	ENST00000358536.4	-	25	5030	c.4761G>A	c.(4759-4761)cgG>cgA	p.R1587R	PLXNB1_ENST00000358459.4_Silent_p.R1404R|PLXNB1_ENST00000456774.1_Silent_p.R1404R|PLXNB1_ENST00000296440.6_Silent_p.R1587R|PLXNB1_ENST00000448774.2_Silent_p.R198R	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1587					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CACCCAGGTCCCGGTGCAAGG	0.627000													7	39					0	0	0.003080	0	0
SLC16A12	387700	broad.mit.edu	37	10	91196038	91196038	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:91196038G>A	ENST00000341233.4	-	7	1367	c.977C>T	c.(976-978)gCc>gTc	p.A326V	SLC16A12_ENST00000371790.4_Missense_Mutation_p.A356V	NM_213606.3	NP_998771.3	Q6ZSM3	MOT12_HUMAN	solute carrier family 16, member 12	326						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						CATTCCCACGGCAAAGAGGTA	0.458000													5	39					0	0	0.003080	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981989	61981989	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:61981989G>A	ENST00000370263.4	-	5	995	c.774C>T	c.(772-774)tcC>tcT	p.S258S	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	258					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CGGTGAGGCAGGAGATGAGCA	0.602000													27	44					0	0	0.008361	0	0
MYNN	55892	broad.mit.edu	37	3	169496554	169496554	+	Splice_Site	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:169496554A>T	ENST00000349841.5	+	3	929		c.e3-1		MYNN_ENST00000544106.1_Splice_Site|MYNN_ENST00000392733.1_Splice_Site|MYNN_ENST00000356716.4_Splice_Site|RP11-362K14.5_ENST00000602342.1_RNA	NM_018657.4	NP_061127.1	Q9NPC7	MYNN_HUMAN	myoneurin							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			GTTTCCTTGCAGTTGGAATGT	0.343000													27	117					0	0	0.004656	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133285	91133285	+	Silent	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:91133285T>C	ENST00000373094.1	+	2	2891	c.2046T>C	c.(2044-2046)taT>taC	p.Y682Y	PCDH11X_ENST00000298274.8_Silent_p.Y682Y|PCDH11X_ENST00000361724.1_Silent_p.Y682Y|PCDH11X_ENST00000373097.1_Silent_p.Y682Y|PCDH11X_ENST00000361655.2_Silent_p.Y682Y|PCDH11X_ENST00000373088.1_Silent_p.Y682Y|PCDH11X_ENST00000406881.1_Silent_p.Y682Y|PCDH11X_ENST00000504220.1_Silent_p.Y682Y|PCDH11X_ENST00000395337.2_Silent_p.Y682Y	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	682	Cadherin 7.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						ACTGTTCTTATGAATTGGTTC	0.423000													24	37					0	0	0.002780	0	0
GPX5	2880	broad.mit.edu	37	6	28497304	28497304	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:28497304C>T	ENST00000412168.2	+	2	253	c.164C>T	c.(163-165)tCc>tTc	p.S55F	GPX5_ENST00000469384.1_Missense_Mutation_p.S55F|GPX5_ENST00000442674.2_3'UTR	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	55					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	GAATATGTTTCCTTCAAGCAG	0.423000													18	91					0	0	0.007413	0	0
DNAH5	1767	broad.mit.edu	37	5	13868074	13868074	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:13868074C>T	ENST00000265104.4	-	25	3966	c.3862G>A	c.(3862-3864)Gga>Aga	p.G1288R	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1288	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATCAGAAGTCCATATCTGTTA	0.388000									Kartagener syndrome				12	28					0	0	0.010729	0	0
ZNF615	284370	broad.mit.edu	37	19	52497966	52497966	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:52497966G>A	ENST00000602063.1	-	6	712	c.363C>T	c.(361-363)ttC>ttT	p.F121F	ZNF615_ENST00000594083.1_Silent_p.F132F|ZNF615_ENST00000598071.1_Silent_p.F132F|ZNF615_ENST00000391795.3_Silent_p.F126F|ZNF615_ENST00000376716.5_Silent_p.F121F			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GCTTCAGCAGGAAATGACCTT	0.343000													12	27					0	0	0.001855	0	0
AK5	26289	broad.mit.edu	37	1	78024300	78024300	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:78024300G>T	ENST00000344720.5	+	14	2582	c.1556G>T	c.(1555-1557)gGa>gTa	p.G519V	AK5_ENST00000354567.2_Missense_Mutation_p.G545V|AK5_ENST00000478255.1_Missense_Mutation_p.G60V	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	545					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						AATGCAGAGGGAACACCAGAG	0.313000													9	55					0.00448238	0.00462191	0.004482	1	0
SLC16A14	151473	broad.mit.edu	37	2	230910950	230910950	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:230910950C>T	ENST00000295190.4	-	4	1350	c.892G>A	c.(892-894)Gag>Aag	p.E298K		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	298						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TACCAGTCCTCGAAGCCCTTC	0.512000													4	36					0	0	0.009096	0	0
CTNNB1	1499	broad.mit.edu	37	3	41266104	41266104	+	Missense_Mutation	SNP	G	G	A	rs28931589		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:41266104G>A	ENST00000349496.5	+	3	381	c.101G>A	c.(100-102)gGa>gAa	p.G34E	CTNNB1_ENST00000396183.3_Missense_Mutation_p.G34E|CTNNB1_ENST00000405570.1_Missense_Mutation_p.G34E|CTNNB1_ENST00000453024.1_Missense_Mutation_p.G27E|CTNNB1_ENST00000396185.3_Missense_Mutation_p.G34E	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	34			G -> E (in PTR).|G -> R (in hepatocellular carcinoma).|G -> V (in hepatoblastoma; dbSNP:rs28931589).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.G34E(73)|p.G34V(72)|p.A5_A80del(53)|p.A5_Q143del(7)|p.A5_A80>D(7)|p.Q28_H134del(5)|p.?(4)|p.V22_G38del(3)|p.W25_I140del(3)|p.T3_A126del(2)|p.A5fs*7(2)|p.D32_S47del(2)|p.M5_N141>D(2)|p.L10_N141del(2)|p.A5_Y142>D(2)|p.A5_Q143>E(1)|p.A13_R151del(1)|p.D32_H36>D(1)|p.M14_S45del(1)|p.A20_N141del(1)|p.M1_A87del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.S23_I35del(1)|p.Y30_A97del(1)|p.V22_T102del(1)|p.A20_A80del(1)|p.V22_S71>A(1)|p.Q28_A43del(1)|p.A5_T59del(1)|p.A20_I35del(1)|p.M1_V173del(1)|p.E15_I140>V(1)|p.S23_A39del(1)|p.H24_M131del(1)|p.A21_A80del(1)|p.D32fs*9(1)|p.A5_T40del(1)|p.S29_H36del(1)|p.A5_E54del(1)|p.W25_I35del(1)|p.S33_S37del(1)|p.M8_A80del(1)|p.P16_K133del(1)|p.V22_Y64del(1)|p.Q28_Q61del(1)|p.A20_S111del(1)|p.Y30_T40del(1)|p.GIHS34?(1)|p.A5_I35del(1)|p.D32_H36del(1)|p.Y30_A80del(1)	CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	CTGGACTCTGGAATCCATTCT	0.488000	G34E(AGS_STOMACH)	15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				7	32					0	0	0.003080	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138387	126138387	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:126138387G>A	ENST00000299308.3	+	9	2376	c.2368G>A	c.(2368-2370)Gaa>Aaa	p.E790K	TMEM132B_ENST00000535886.1_Missense_Mutation_p.E302K	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	790						integral to membrane		p.E790K(1)		NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GGTCAAATTCGAACCAAGTAG	0.423000													16	49					0	0	0.006122	0	0
LRRC16B	90668	broad.mit.edu	37	14	24534423	24534423	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:24534423G>A	ENST00000342740.5	+	33	3491	c.3337G>A	c.(3337-3339)Gag>Aag	p.E1113K	LRRC16B_ENST00000334420.7_Missense_Mutation_p.E209K	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1113										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		CCCAGAGGAGGAGAGCAGCCT	0.667000													4	20					0	0	0.000602	0	0
CPM	1368	broad.mit.edu	37	12	69265610	69265610	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:69265610C>T	ENST00000551568.1	-	4	445	c.385G>A	c.(385-387)Gga>Aga	p.G129R	CPM_ENST00000338356.3_Missense_Mutation_p.G129R|CPM_ENST00000546373.1_Missense_Mutation_p.G129R	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	129					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			GCTTCAAATCCATCTGGGTTC	0.438000													19	110					0	0	0.012319	0	0
HDC	3067	broad.mit.edu	37	15	50535170	50535170	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:50535170C>T	ENST00000267845.3	-	12	1678	c.1276G>A	c.(1276-1278)Gaa>Aaa	p.E426K	HDC_ENST00000543581.1_Missense_Mutation_p.E393K	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	426					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TTAGCTATTTCCTTTAACACA	0.473000													13	50					0	0	0.002450	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99448932	99448932	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:99448932G>A	ENST00000397899.2	-	5	750	c.419C>T	c.(418-420)cCa>cTa	p.P140L	KIAA1211L_ENST00000462314.1_5'UTR	NM_207362.2	NP_997245.2			KIAA1211-like																		AAGCCCCCCTGGAGGAGGTGG	0.507000													10	48					0	0	0.006214	0	0
SCAND3	114821	broad.mit.edu	37	6	28541016	28541016	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:28541016C>T	ENST00000452236.2	-	4	3267	c.2650G>A	c.(2650-2652)Gat>Aat	p.D884N		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	884					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						tcttccatatcattagccagt	0.368000													10	117					0	0	0.010729	0	0
DIRC1	116093	broad.mit.edu	37	2	189599568	189599568	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:189599568G>A	ENST00000308100.4	-	2	350	c.80C>T	c.(79-81)tCc>tTc	p.S27F	AC079613.1_ENST00000431708.1_RNA	NM_052952.2	NP_443184.1	Q969H9	DIRC1_HUMAN	disrupted in renal carcinoma 1	27										large_intestine(1)|lung(6)	7			OV - Ovarian serous cystadenocarcinoma(117;0.00842)|Epithelial(96;0.102)			CAAGTAACAGGAAACAGGCTT	0.532000													17	52					0	0	0.004990	0	0
OR51V1	283111	broad.mit.edu	37	11	5221006	5221006	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:5221006G>A	ENST00000321255.1	-	1	924	c.925C>T	c.(925-927)Cat>Tat	p.H309Y		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTCTGGTATGAATCTGTTGG	0.388000													12	33					0	0	0.001855	0	0
RBPMS2	348093	broad.mit.edu	37	15	65040755	65040755	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:65040755C>A	ENST00000300069.4	-	6	697	c.430G>T	c.(430-432)Ggg>Tgg	p.G144W	RBPMS2_ENST00000560606.1_Missense_Mutation_p.G33W	NM_194272.1	NP_919248.1	Q6ZRY4	RBPS2_HUMAN	RNA binding protein with multiple splicing 2	144							nucleic acid binding|nucleotide binding			breast(1)|large_intestine(3)|lung(3)|prostate(1)	8						AGAGCAGCCCCCATCAGGTCA	0.587000													21	63					0.000295444	0.000305234	0.014323	1	0
C10orf76	79591	broad.mit.edu	37	10	103792895	103792895	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:103792895G>A	ENST00000370033.4	-	4	313	c.194C>T	c.(193-195)tCt>tTt	p.S65F	C10orf76_ENST00000311122.5_Missense_Mutation_p.S65F	NM_024541.2	NP_078817.2	Q5T2E6	CJ076_HUMAN	chromosome 10 open reading frame 76	65						integral to membrane				autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|upper_aerodigestive_tract(2)	24		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		ACCATCAAGAGATTCCAGCTT	0.438000													16	66					0	0	0.003163	0	0
ATP2B4	493	broad.mit.edu	37	1	203696545	203696545	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:203696545G>A	ENST00000357681.5	+	20	4278	c.3155G>A	c.(3154-3156)cGa>cAa	p.R1052Q	ATP2B4_ENST00000367218.3_Missense_Mutation_p.R1052Q|ATP2B4_ENST00000466407.1_3'UTR|ATP2B4_ENST00000341360.2_Missense_Mutation_p.R1052Q|ATP2B4_ENST00000391954.2_Missense_Mutation_p.R1016Q|ATP2B4_ENST00000367219.3_Missense_Mutation_p.R1040Q	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	1052					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATACCTACCCGATCCCTGAAG	0.532000													19	73					0	0	0.007413	0	0
MYH1	4619	broad.mit.edu	37	17	10416982	10416982	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:10416982C>T	ENST00000226207.5	-	9	860	c.766G>A	c.(766-768)Ggt>Agt	p.G256S	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	256	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CCTGTGGTACCGAAGTGGATC	0.393000													4	28					0	0	0.000602	0	0
OR7D4	125958	broad.mit.edu	37	19	9324751	9324751	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9324751C>T	ENST00000308682.2	-	1	791	c.763G>A	c.(763-765)Gga>Aga	p.G255R		NM_001005191.2	NP_001005191.1	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D, member 4	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|skin(3)|stomach(1)	26						ACCCCAAGTCCTGTTCCATAG	0.532000													6	43					0	0	0.001168	0	0
IL18RAP	8807	broad.mit.edu	37	2	103068610	103068610	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:103068610C>T	ENST00000264260.2	+	12	2358	c.1769C>T	c.(1768-1770)aCt>aTt	p.T590I	IL18RAP_ENST00000409369.1_Missense_Mutation_p.T448I	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	590					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						ACAGAAACCACTGGGAGGAGC	0.512000													15	83					0	0	0.002450	0	0
LNPEP	4012	broad.mit.edu	37	5	96349452	96349452	+	Silent	SNP	A	A	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:96349452A>C	ENST00000231368.5	+	12	2828	c.2136A>C	c.(2134-2136)ctA>ctC	p.L712L	LNPEP_ENST00000395770.3_Silent_p.L698L	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	712					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		GGGAAGCACTAATCCATCAGT	0.363000													24	68					0	0	0.014323	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430661	37430661	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:37430661G>A	ENST00000374660.1	+	7	767	c.668G>A	c.(667-669)gGa>gAa	p.G223E	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.G223E|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.G223E			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	279						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ACATCTGCAGGAACACCTGAT	0.463000													8	28					0	0	0.003080	0	0
IDO2	169355	broad.mit.edu	37	8	39872851	39872851	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:39872851G>A	ENST00000502986.2	+	11	1235	c.993G>A	c.(991-993)agG>agA	p.R331R	IDO2_ENST00000389060.4_Silent_p.R318R|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	318					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						CTTCCCTGAGGGACTACATCC	0.498000													8	36					0	0	0.004482	0	0
KCTD1	284252	broad.mit.edu	37	18	24081143	24081143	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:24081143G>A	ENST00000417602.1	-	2	1880	c.1881C>T	c.(1879-1881)atC>atT	p.I627I	KCTD1_ENST00000579973.1_Silent_p.I19I|KCTD1_ENST00000317932.7_Silent_p.I19I|KCTD1_ENST00000580059.1_Silent_p.I19I|KCTD1_ENST00000408011.3_Silent_p.I19I	NM_001142730.2	NP_001136202.1	Q719H9	KCTD1_HUMAN	potassium channel tetramerization domain containing 1	19					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(3)	12	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			CTGGAGTAGGGATGCCTTGGT	0.512000													22	106					0	0	0.014323	0	0
PDZD2	23037	broad.mit.edu	37	5	31983668	31983668	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:31983668C>T	ENST00000438447.1	+	3	1272	c.884C>T	c.(883-885)cCa>cTa	p.P295L	PDZD2_ENST00000282493.3_Missense_Mutation_p.P295L			O15018	PDZD2_HUMAN	PDZ domain containing 2	295					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CATAGAATTCCAAAGACAGAT	0.517000													35	108					0	0	0.005524	0	0
CCDC158	339965	broad.mit.edu	37	4	77324294	77324294	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:77324294C>T	ENST00000388914.3	-	2	219	c.67G>A	c.(67-69)Gga>Aga	p.G23R	CCDC158_ENST00000504868.1_5'UTR|CCDC158_ENST00000434846.2_Missense_Mutation_p.G23R	NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	23										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						CACATACCTCCATTAGATGTG	0.294000													10	23					0	0	0.008291	0	0
NYAP2	57624	broad.mit.edu	37	2	226273743	226273743	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:226273743G>A	ENST00000272907.6	+	2	560	c.147G>A	c.(145-147)ttG>ttA	p.L49L	NYAP2_ENST00000409269.2_Silent_p.L49L	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	49																	ATGATCGCTTGAGAAATGAAA	0.373000													7	37					0	0	0.001984	0	0
C3	718	broad.mit.edu	37	19	6685057	6685057	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:6685057C>T	ENST00000245907.6	-	30	4003	c.3911G>A	c.(3910-3912)aGc>aAc	p.S1304N		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1304		Cleavage; by factor I.			complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GATCTTGGAGCTGCGGCTGGG	0.582000													6	31					0	0	0.001984	0	0
MTERFD1	51001	broad.mit.edu	37	8	97270800	97270800	+	Missense_Mutation	SNP	C	C	T	rs148966759		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:97270800C>T	ENST00000523821.1	-	2	238	c.119G>A	c.(118-120)gGc>gAc	p.G40D	MTERFD1_ENST00000287025.3_Missense_Mutation_p.G40D			Q96E29	MTER1_HUMAN	MTERF domain containing 1	40					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	24	Breast(36;5.16e-05)					AGCAGAAAAGCCATGTAACAG	0.428000													18	99					0	0	0.006122	0	0
ITGA2	3673	broad.mit.edu	37	5	52371124	52371124	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:52371124C>T	ENST00000296585.5	+	23	2958	c.2815C>T	c.(2815-2817)Cac>Tac	p.H939Y		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	939					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TGCTGAAATTCACTTAACAAG	0.393000													5	28					0	0	0.001168	0	0
CXXC11	285093	broad.mit.edu	37	2	242814358	242814358	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:242814358C>T	ENST00000343216.3	+	2	679	c.651C>T	c.(649-651)ccC>ccT	p.P217P		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	217						integral to membrane											ACCAGGTGCCCATCGCTGAGG	0.672000													15	51					0	0	0.004007	0	0
RBP3	5949	broad.mit.edu	37	10	48388012	48388012	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:48388012C>T	ENST00000224600.4	-	1	2979	c.2866G>A	c.(2866-2868)Gag>Aag	p.E956K		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	956	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity	p.E956K(1)		central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GCCCCCAGCTCGGCAGAGGCA	0.632000													20	65					0	0	0.008871	0	0
HIF3A	64344	broad.mit.edu	37	19	46834519	46834519	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:46834519C>T	ENST00000339613.2	+	13	1906	c.1651C>T	c.(1651-1653)Cct>Tct	p.P551S	HIF3A_ENST00000244303.6_Missense_Mutation_p.P538S|HIF3A_ENST00000300862.3_Missense_Mutation_p.P605S|HIF3A_ENST00000600383.1_Missense_Mutation_p.P538S|AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000420102.2_Missense_Mutation_p.P556S|HIF3A_ENST00000377670.4_Missense_Mutation_p.P607S|HIF3A_ENST00000472815.1_Intron			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	607	ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity	p.P605S(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		TCTGCTCTTTCCTCTCAGCCT	0.542000													14	49					0	0	0.004990	0	0
EPPK1	83481	broad.mit.edu	37	8	144940581	144940581	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:144940581G>A	ENST00000525985.1	-	2	6912	c.6841C>T	c.(6841-6843)Ctg>Ttg	p.L2281L				P58107	EPIPL_HUMAN	epiplakin 1	2281						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCCACCGACAGCCTCAGGTTG	0.736000													9	92					0	0	0.004482	0	0
TANC2	26115	broad.mit.edu	37	17	61498822	61498822	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:61498822T>A	ENST00000424789.2	+	25	5483	c.5479T>A	c.(5479-5481)Tct>Act	p.S1827T	TANC2_ENST00000389520.4_Missense_Mutation_p.S1837T|RP11-269G24.3_ENST00000583552.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1827							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						GTCGCCAGTGTCTCCAACTCA	0.537000													3	26					0	0	0.004672	0	0
TTLL2	83887	broad.mit.edu	37	6	167754861	167754861	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:167754861G>A	ENST00000239587.5	+	3	1561	c.1473G>A	c.(1471-1473)gaG>gaA	p.E491E		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	491					protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TGGAAGGAGAGATGAGTGGGC	0.532000													6	56					0	0	0.001168	0	0
NXPE3	91775	broad.mit.edu	37	3	101520777	101520777	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:101520777C>T	ENST00000422132.1	+	2	989	c.792C>T	c.(790-792)ttC>ttT	p.F264F	NXPE3_ENST00000273347.5_Silent_p.F264F|NXPE3_ENST00000477909.1_Silent_p.F264F|NXPE3_ENST00000491511.1_Silent_p.F264F					neurexophilin and PC-esterase domain family, member 3																		TTACCCATTTCAAAGGTGGAT	0.473000													13	93					0	0	0.003163	0	0
SCYL1	57410	broad.mit.edu	37	11	65298163	65298163	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:65298163C>T	ENST00000524944.1	+	7	946	c.913C>T	c.(913-915)Cct>Tct	p.P305S	SCYL1_ENST00000527009.1_Missense_Mutation_p.P162S|SCYL1_ENST00000525364.1_Missense_Mutation_p.P305S|SCYL1_ENST00000527630.1_Missense_Mutation_p.P305S|SCYL1_ENST00000533862.1_Missense_Mutation_p.P305S|SCYL1_ENST00000420247.2_Missense_Mutation_p.P305S|SCYL1_ENST00000270176.5_Missense_Mutation_p.P305S|SCYL1_ENST00000279270.6_Missense_Mutation_p.P305S			Q96KG9	NTKL_HUMAN	SCY1-like 1 (S. cerevisiae)	305	Protein kinase.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			ovary(1)|skin(1)	2						GGACGCATTCCCTGAGGATTT	0.597000													24	72					0	0	0.003954	0	0
OSBPL3	26031	broad.mit.edu	37	7	24849512	24849512	+	Missense_Mutation	SNP	C	C	T	rs61756017	byFrequency	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:24849512C>T	ENST00000313367.2	-	20	2682	c.2231G>A	c.(2230-2232)gGa>gAa	p.G744E	OSBPL3_ENST00000396429.1_Missense_Mutation_p.G708E|OSBPL3_ENST00000487020.1_5'UTR|OSBPL3_ENST00000409069.1_Missense_Mutation_p.G677E|OSBPL3_ENST00000431825.2_Missense_Mutation_p.G677E|OSBPL3_ENST00000353930.1_Missense_Mutation_p.G708E|OSBPL3_ENST00000352860.1_Missense_Mutation_p.G713E|OSBPL3_ENST00000396431.1_Missense_Mutation_p.G713E	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	744					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						AACCGCTTTTCCACTCCTGTC	0.488000													42	124					0	0	0.010771	0	0
CLCN7	1186	broad.mit.edu	37	16	1500570	1500570	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:1500570G>A	ENST00000382745.4	-	17	2150	c.1545C>T	c.(1543-1545)atC>atT	p.I515I	CLCN7_ENST00000448525.1_Silent_p.I491I|CLCN7_ENST00000262318.8_Silent_p.I491I	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	515						integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				GCAGGGACGGGATGAAGACCC	0.677000													5	23					0	0	0.000602	0	0
AKAP11	11215	broad.mit.edu	37	13	42873637	42873637	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:42873637C>T	ENST00000025301.2	+	8	930	c.755C>T	c.(754-756)tCa>tTa	p.S252L		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	252	Ser-rich.				intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TCAACTTCCTCAGTGAATGTC	0.423000													17	49					0	0	0.006122	0	0
VPRBP	9730	broad.mit.edu	37	3	51517738	51517738	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:51517738G>A	ENST00000335891.5	-	1	116	c.107C>T	c.(106-108)aCc>aTc	p.T36I				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	36					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		TTCATACCTGGTAAGGATAGG	0.438000													21	80					0	0	0.014323	0	0
TRBV25-1	28562	broad.mit.edu	37	7	142378840	142378840	+	RNA	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:142378840G>A	ENST00000390398.3	+	0	145																											GCACAGGAAAGAAGATCACTC	0.438000													19	162					0	0	0.008871	0	0
FLG2	388698	broad.mit.edu	37	1	152323829	152323829	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:152323829C>T	ENST00000388718.5	-	3	6505	c.6433G>A	c.(6433-6435)Gga>Aga	p.G2145R	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2145							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTATAGTTCCCTGTCTCCCG	0.507000													80	300					0	0	0.014410	0	0
CYP4A11	1579	broad.mit.edu	37	1	47403783	47403783	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:47403783C>T	ENST00000310638.4	-	2	253	c.222G>A	c.(220-222)cgG>cgA	p.R74R	CYP4A11_ENST00000457840.2_5'UTR|CYP4A11_ENST00000371905.1_Silent_p.R74R|CYP4A11_ENST00000371904.4_Silent_p.R74R|CYP4A11_ENST00000475477.1_5'UTR	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	74					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	ATTTCTGAATCCGTTGTAGCT	0.488000													15	77					0	0	0.004007	0	0
SNHG14	104472715	broad.mit.edu	37	15	25449558	25449558	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:25449558C>T	ENST00000424208.1	+	0	2339				SNHG14_ENST00000424333.1_RNA|SNORD115-19_ENST00000363098.1_RNA	NR_003305.1																						ACTTAAAAATCATTCTCAAAA	0.507000													25	144					0	0	0.003330	0	0
KCNH7	90134	broad.mit.edu	37	2	163291874	163291874	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:163291874C>T	ENST00000332142.5	-	8	1887	c.1788G>A	c.(1786-1788)ggG>ggA	p.G596G	KCNH7_ENST00000328032.4_Silent_p.G589G	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	596					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TGTAACGTTTCCCAATTTGCT	0.428000													13	48					0	0	0.002450	0	0
POLE	5426	broad.mit.edu	37	12	133212577	133212577	+	Silent	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:133212577T>C	ENST00000320574.5	-	42	5755	c.5712A>G	c.(5710-5712)acA>acG	p.T1904T	POLE_ENST00000535270.1_Silent_p.T1877T|POLE_ENST00000434528.3_5'UTR	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1904					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		AGAAAGAAATTGTCAGAGAAT	0.428000								DNA polymerases (catalytic subunits)					11	45					0	0	0.013537	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951534	119951534	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:119951534C>T	ENST00000307142.4	+	4	1800	c.1604C>T	c.(1603-1605)tCt>tTt	p.S535F	SYNPO2_ENST00000434046.2_Missense_Mutation_p.S535F|SYNPO2_ENST00000429713.2_Missense_Mutation_p.S535F|SYNPO2_ENST00000448416.2_Intron	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	535						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ACCACGACTTCTTACCAAAGA	0.502000													10	33					0	0	0.008291	0	0
SLC37A3	84255	broad.mit.edu	37	7	140035266	140035266	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:140035266C>T	ENST00000340308.3	-	12	1240	c.1129G>A	c.(1129-1131)Gag>Aag	p.E377K	SLC37A3_ENST00000326232.9_Silent_p.V477V|SLC37A3_ENST00000447932.2_Silent_p.V461V	NM_032295.2	NP_115671.1	Q8NCC5	SPX3_HUMAN	solute carrier family 37, member 3	0					carbohydrate transport|transmembrane transport	integral to membrane				endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|stomach(3)	24	Melanoma(164;0.0142)					ATATTTCCCTCACTATTAATG	0.418000													10	69					0	0	0.006214	0	0
ATP8A1	10396	broad.mit.edu	37	4	42457331	42457331	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:42457331G>A	ENST00000381668.5	-	29	3031	c.2800C>T	c.(2800-2802)Ctg>Ttg	p.L934L	ATP8A1_ENST00000264449.10_Silent_p.L919L	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	934					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	TTGAAGTCCAGGGCATTCTGA	0.433000													15	40					0	0	0.004990	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94881099	94881099	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:94881099G>A	ENST00000289495.5	+	9	2572	c.2356G>A	c.(2356-2358)Gaa>Aaa	p.E786K	PPP1R9A_ENST00000433881.1_Missense_Mutation_p.E786K|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.E786K|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.E786K|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.E786K|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.E808K	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	786	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CAAAAGACAGGAAGCAGAAAG	0.338000										HNSCC(28;0.073)			11	26					0	0	0.013537	0	0
MUC16	94025	broad.mit.edu	37	19	9080519	9080519	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9080519G>A	ENST00000397910.4	-	2	9715	c.9512C>T	c.(9511-9513)tCa>tTa	p.S3171L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3172	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGCCTGGCTTGACATCTTTAT	0.473000													16	118					0	0	0.008871	0	0
TMEM19	55266	broad.mit.edu	37	12	72092798	72092798	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:72092798C>T	ENST00000266673.5	+	5	1350	c.756C>T	c.(754-756)gcC>gcT	p.A252A	TMEM19_ENST00000549735.1_Silent_p.A252A	NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	252						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		ACATTTCTGCCCCGCAGTGGC	0.453000													11	98					0	0	0.010729	0	0
MYOCD	93649	broad.mit.edu	37	17	12656366	12656366	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:12656366G>A	ENST00000425538.1	+	10	1961	c.1761G>A	c.(1759-1761)gtG>gtA	p.V587V	MYOCD_ENST00000395988.1_Silent_p.V491V|MYOCD_ENST00000343344.4_Silent_p.V587V	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	587					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AAGTACCTGTGAAAAGACAAA	0.517000													11	66					0	0	0.010729	0	0
KCNN3	3782	broad.mit.edu	37	1	154680526	154680526	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:154680526G>A	ENST00000271915.3	-	8	2437	c.2122C>T	c.(2122-2124)Cca>Tca	p.P708S	KCNN3_ENST00000361147.4_Missense_Mutation_p.P403S|KCNN3_ENST00000515643.1_5'UTR|KCNN3_ENST00000358505.2_Missense_Mutation_p.P395S	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	713						integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TCGGAGATTGGGGTGTGGGTG	0.607000													34	132					0	0	0.004289	0	0
OR2A25	392138	broad.mit.edu	37	7	143771756	143771756	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:143771756G>A	ENST00000408898.2	+	1	482	c.444G>A	c.(442-444)tgG>tgA	p.W148*		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					TGACTTCCTGGATTTTAGGAG	0.458000													28	142					0	0	0.008361	0	0
GALNTL6	442117	broad.mit.edu	37	4	173942764	173942764	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:173942764G>A	ENST00000506823.1	+	12	2283	c.1626G>A	c.(1624-1626)tgG>tgA	p.W542*	GALNTL6_ENST00000508122.1_Nonsense_Mutation_p.W525*	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	542	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						ACCAGCTCTGGGGATACCGGA	0.458000													25	116					0	0	0.008361	0	0
C7orf60	154743	broad.mit.edu	37	7	112462082	112462082	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:112462082T>A	ENST00000297145.4	-	5	1100	c.935A>T	c.(934-936)cAt>cTt	p.H312L		NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	312										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						CAGATGCATATGTGAAAATTT	0.388000													15	38					0	0	0.004990	0	0
FLG	2312	broad.mit.edu	37	1	152279804	152279804	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:152279804C>T	ENST00000368799.1	-	3	7593	c.7558G>A	c.(7558-7560)Gat>Aat	p.D2520N	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2520	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATTGTTCATCGTTACGAGTT	0.587000									Ichthyosis				82	289					0	0	0.014410	0	0
MIR381HG	378881	broad.mit.edu	37	14	101512845	101512845	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:101512845C>T	ENST00000553692.1	+	0	28				MIR487B_ENST00000385021.1_RNA																							CATGTCGAATCGTACAGGGTC	0.488000													14	32					0	0	0.003163	0	0
ZNF215	7762	broad.mit.edu	37	11	6977643	6977643	+	Nonsense_Mutation	SNP	C	C	T	rs142083471		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:6977643C>T	ENST00000278319.5	+	7	2023	c.1435C>T	c.(1435-1437)Cga>Tga	p.R479*	ZNF215_ENST00000414517.2_Nonsense_Mutation_p.R479*|ZNF215_ENST00000529903.1_Intron	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	479					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CTCTCTTATTCGACACCAAAT	0.368000													10	63					0	0	0.013537	0	0
CCDC141	285025	broad.mit.edu	37	2	179720245	179720245	+	Silent	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:179720245T>C	ENST00000420890.2	-	19	3006	c.2889A>G	c.(2887-2889)aaA>aaG	p.K963K	CCDC141_ENST00000295723.5_Silent_p.K388K	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	388							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TATTACTAACTTTTTCCATTT	0.284000													6	33					0	0	0.001984	0	0
TNXB	7148	broad.mit.edu	37	6	32012848	32012848	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:32012848C>T	ENST00000375244.3	-	32	11063	c.10862G>A	c.(10861-10863)aGg>aAg	p.R3621K	TNXB_ENST00000375247.2_Missense_Mutation_p.R3619K|TNXB_ENST00000451343.1_Missense_Mutation_p.R50K			P22105	TENX_HUMAN	tenascin XB	3666	Fibronectin type-III 28.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GAGGAGGAACCTGTAGGGGGT	0.647000													78	163					0	0	0.014410	0	0
UGT2B28	54490	broad.mit.edu	37	4	70146450	70146450	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:70146450C>T	ENST00000335568.5	+	1	234	c.232C>T	c.(232-234)Cct>Tct	p.P78S	UGT2B28_ENST00000511240.1_Missense_Mutation_p.P78S	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	78					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	CGAAGTTTATCCTACATCTTT	0.363000													16	46					0	0	0.003163	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125232112	125232112	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:125232112C>T	ENST00000439075.1	-	0	2633					NR_026876.1																						CGGCAAATTTCGACTGCTCCA	0.308000													7	49					0	0	0.006214	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72954598	72954598	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:72954598C>T	ENST00000421285.3	+	11	853	c.853C>T	c.(853-855)Ccc>Tcc	p.P285S		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	285										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						CTCAGCTAAGCCCCCATCCCT	0.522000													21	49					0	0	0.003330	0	0
DPRX	503834	broad.mit.edu	37	19	54140182	54140182	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:54140182C>T	ENST00000376650.1	+	3	567	c.516C>T	c.(514-516)tgC>tgT	p.C172C		NM_001012728.1	NP_001012746.1	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	172						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|large_intestine(1)|lung(7)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		CCCAAGTTTGCGCTCCAAGCT	0.443000													27	99					0	0	0.007291	0	0
ZNF761	388561	broad.mit.edu	37	19	53958449	53958449	+	RNA	SNP	T	T	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:53958449T>A	ENST00000454407.1	+	0	1141							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		CAGCTCACTCTTAAGGAAACA	0.368000													24	80					0	0	0.003330	0	0
ZNF99	7652	broad.mit.edu	37	19	22940113	22940113	+	Missense_Mutation	SNP	G	G	A	rs74174099		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:22940113G>A	ENST00000397104.3	-	6	2217	c.2218C>T	c.(2218-2220)Cat>Tat	p.H740Y						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTCCAGTATGAATTATCTCA	0.348000													9	31					0	0	0.010729	0	0
SCPEP1	59342	broad.mit.edu	37	17	55078337	55078337	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:55078337C>T	ENST00000262288.3	+	11	1171	c.1116C>T	c.(1114-1116)ctC>ctT	p.L372L		NM_021626.2	NP_067639.1	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1	372					proteolysis	extracellular region	serine-type carboxypeptidase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	14	Breast(9;2.86e-08)					AGCTGGATCTCATCGTAGATA	0.498000													17	95					0	0	0.010504	0	0
RUFY4	285180	broad.mit.edu	37	2	218940409	218940409	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:218940409C>T	ENST00000374155.3	+	8	1664	c.1254C>T	c.(1252-1254)acC>acT	p.T418T	RUFY4_ENST00000463872.1_3'UTR|RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000344321.7_Silent_p.T398T			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	398							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CAGAAGTGACCCTTGTGGCCA	0.572000													16	79					0	0	0.008871	0	0
SLC4A1	6521	broad.mit.edu	37	17	42335031	42335031	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:42335031A>C	ENST00000262418.6	-	12	1582	c.1427T>G	c.(1426-1428)tTc>tGc	p.F476C		NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	476	Membrane (anion exchange).				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		AACTACCGAGAAGAAGGCTTC	0.612000													4	20					0	0	0.009096	0	0
CACNG7	59284	broad.mit.edu	37	19	54444813	54444813	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:54444813C>T	ENST00000391767.1	+	5	726	c.514C>T	c.(514-516)Cat>Tat	p.H172Y	CACNG7_ENST00000468076.1_3'UTR|CACNG7_ENST00000391766.1_Missense_Mutation_p.H172Y|CACNG7_ENST00000222212.2_Missense_Mutation_p.H172Y			P62955	CCG7_HUMAN	calcium channel, voltage-dependent, gamma subunit 7	172					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		GCAGTATTTTCATTATCGCTA	0.532000													34	124					0	0	0.003755	0	0
OR7G2	390882	broad.mit.edu	37	19	9213689	9213689	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9213689C>T	ENST00000305456.2	-	1	293	c.294G>A	c.(292-294)acG>acA	p.T98T		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						TCTTTGGGATCGTGGTTGTGC	0.488000													12	78					0	0	0.013537	0	0
SLC38A4	55089	broad.mit.edu	37	12	47181792	47181792	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:47181792C>T	ENST00000447411.1	-	4	439	c.233G>A	c.(232-234)gGa>gAa	p.G78E	SLC38A4_ENST00000266579.4_Missense_Mutation_p.G78E	NM_001143824.1	NP_001137296.1	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	78					cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					TGAAGACATTCCAAAGGAAGT	0.428000													8	41					0	0	0.006214	0	0
C2orf80	389073	broad.mit.edu	37	2	209047720	209047720	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:209047720C>T	ENST00000341287.4	-	4	370	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K	C2orf80_ENST00000453017.1_Missense_Mutation_p.E59K|C2orf80_ENST00000451346.1_Missense_Mutation_p.E40K	NM_001099334.2	NP_001092804.1	Q0P641	CB080_HUMAN	chromosome 2 open reading frame 80	59										endometrium(2)|large_intestine(3)|lung(6)|skin(2)	13						GTTAAGTCTTCTGAGGGATCC	0.458000													34	106					0	0	0.005524	0	0
OR51D1	390038	broad.mit.edu	37	11	4661144	4661144	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:4661144T>G	ENST00000357605.2	+	1	200	c.124T>G	c.(124-126)Ttc>Gtc	p.F42V		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTGGCTGGCTTTCCCACTGTG	0.517000													8	48					0	0	0.003080	0	0
DNAH9	1770	broad.mit.edu	37	17	11687739	11687739	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:11687739C>T	ENST00000262442.3	+	41	8012	c.7944C>T	c.(7942-7944)atC>atT	p.I2648I	DNAH9_ENST00000454412.2_Silent_p.I2648I	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2648	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGAAATCCATCCCCCCACTGA	0.532000													30	143					0	0	0.013726	0	0
BRWD3	254065	broad.mit.edu	37	X	79980546	79980546	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:79980546G>A	ENST00000373275.4	-	15	1623	c.1407C>T	c.(1405-1407)ttC>ttT	p.F469F		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	469										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CTTCTAGAACGAATACTTCAT	0.378000													8	10					0	0	0.004482	0	0
SPTA1	6708	broad.mit.edu	37	1	158632546	158632546	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:158632546C>T	ENST00000368148.3	-	17	2590	c.2410G>A	c.(2410-2412)Gat>Aat	p.D804N	SPTA1_ENST00000368147.3_Missense_Mutation_p.D804N	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	804					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GCCTCCTCATCCTCTGTGTCT	0.517000													9	64					0	0	0.010729	0	0
KIAA0430	9665	broad.mit.edu	37	16	15729671	15729671	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:15729671G>A	ENST00000396368.3	-	3	879	c.673C>T	c.(673-675)Ccc>Tcc	p.P225S	KIAA0430_ENST00000602337.1_Missense_Mutation_p.P225S|KIAA0430_ENST00000551742.1_Missense_Mutation_p.P225S|KIAA0430_ENST00000548025.1_Missense_Mutation_p.P225S|KIAA0430_ENST00000540441.2_Missense_Mutation_p.P225S|KIAA0430_ENST00000344181.3_Missense_Mutation_p.P47S	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	224						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TCAGAACAGGGGAAATAGCCA	0.522000													9	67					0	0	0.006214	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140768504	140768504	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:140768504C>T	ENST00000519479.1	+	1	1053	c.1053C>T	c.(1051-1053)ccC>ccT	p.P351P	PCDHGA5_ENST00000518069.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCTCTACCCAACCTAATTA	0.468000													10	49					0	0	0.008291	0	0
CACNB2	783	broad.mit.edu	37	10	18823025	18823025	+	Missense_Mutation	SNP	G	G	A	rs112164873		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:18823025G>A	ENST00000396576.2	+	10	1411	c.910G>A	c.(910-912)Gaa>Aaa	p.E304K	CACNB2_ENST00000282343.8_Missense_Mutation_p.E331K|CACNB2_ENST00000352115.6_Missense_Mutation_p.E335K|CACNB2_ENST00000377329.4_Missense_Mutation_p.E305K|CACNB2_ENST00000377319.3_Missense_Mutation_p.E266K|CACNB2_ENST00000377315.4_Missense_Mutation_p.E311K|CACNB2_ENST00000377331.2_Missense_Mutation_p.E307K|CACNB2_ENST00000324631.7_Missense_Mutation_p.E359K|RP11-499P20.2_ENST00000425669.1_RNA|CACNB2_ENST00000377328.1_Intron	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	359					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GAGTGAAATCGAAAGGATTTT	0.383000													9	42					0	0	0.010729	0	0
GHSR	2693	broad.mit.edu	37	3	172165494	172165494	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:172165494C>T	ENST00000241256.2	-	1	752	c.710G>A	c.(709-711)aGg>aAg	p.R237K	GHSR_ENST00000427970.1_Missense_Mutation_p.R237K	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	237					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CCACAGCTTCCTGCCGATGAG	0.607000													11	45					0	0	0.008291	0	0
C1orf173	127254	broad.mit.edu	37	1	75038009	75038009	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:75038009C>T	ENST00000326665.5	-	14	3603	c.3385G>A	c.(3385-3387)Gaa>Aaa	p.E1129K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1129	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						ACAGGTGCTTCGTTCTCAGCA	0.468000													7	60					0	0	0.001984	0	0
HLA-DRB1	3123	broad.mit.edu	37	6	32549529	32549529	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:32549529G>A	ENST00000360004.5	-	3	562	c.457C>T	c.(457-459)Cca>Tca	p.P153S		NM_002124.3	NP_002115.2			major histocompatibility complex, class II, DR beta 1											large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(2)|stomach(1)	10						ATGCTGCCTGGATAGAAACCA	0.532000										Multiple Myeloma(14;0.17)			5	117					0	0	0.010729	0	0
ACCSL	390110	broad.mit.edu	37	11	44073250	44073250	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:44073250G>A	ENST00000378832.1	+	5	809	c.753G>A	c.(751-753)atG>atA	p.M251I		NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like	251							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						CCCTGGCCATGGTTCTGTGTG	0.502000													47	180					0	0	0.014410	0	0
CACNG3	10368	broad.mit.edu	37	16	24366154	24366154	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:24366154G>A	ENST00000005284.3	+	3	1498	c.295_splice	c.e3-1	p.R99_splice		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	99					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.R99Q(1)		NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		CTCTCCGCAGGAGCTGTGAGG	0.637000													6	59					0	0	0.001984	0	0
CFHR1	3078	broad.mit.edu	37	1	196801023	196801023	+	Missense_Mutation	SNP	C	C	T	rs16840561	byFrequency	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:196801023C>T	ENST00000320493.5	+	6	975	c.887C>T	c.(886-888)gCt>gTt	p.A296V	CFHR1_ENST00000367424.3_Missense_Mutation_p.A237V|CFHR2_ENST00000367421.3_Intron	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1	296	Sushi 5.		A -> V (in dbSNP:rs16840561).		complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						GGTGAATCAGCTGAATTTGTG	0.398000													4	89					0	0	0.004482	0	0
NMBR	4829	broad.mit.edu	37	6	142396941	142396941	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:142396941G>A	ENST00000258042.1	-	3	1157	c.1017C>T	c.(1015-1017)ctC>ctT	p.L339L	NMBR_ENST00000480652.1_5'UTR	NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	339					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		TCCCACAGCAGAGTTGGCTGT	0.478000													31	74					0	0	0.005524	0	0
COL9A1	1297	broad.mit.edu	37	6	70990730	70990730	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:70990730G>A	ENST00000357250.6	-	9	1047	c.889C>T	c.(889-891)Cct>Tct	p.P297S	COL9A1_ENST00000370496.3_Missense_Mutation_p.P297S|COL9A1_ENST00000370499.4_Missense_Mutation_p.P54S|COL9A1_ENST00000320755.7_Missense_Mutation_p.P54S	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	297	Triple-helical region (COL3).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						GGGCCCTTAGGACCTCGGTCA	0.577000													10	54					0	0	0.010729	0	0
ZNF618	114991	broad.mit.edu	37	9	116812241	116812241	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:116812241C>T	ENST00000288466.7	+	14	2479	c.2380C>T	c.(2380-2382)Cct>Tct	p.P794S	ZNF618_ENST00000470105.1_3'UTR|ZNF618_ENST00000374126.5_Missense_Mutation_p.P887S	NM_133374.2	NP_588615.2	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	887					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|lung(10)|urinary_tract(1)	16						CCAGGCTACCCCTGATCTCTT	0.592000													13	75					0	0	0.013537	0	0
ALPP	250	broad.mit.edu	37	2	233246055	233246055	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:233246055G>A	ENST00000392027.2	+	10	1556	c.1287G>A	c.(1285-1287)ccG>ccA	p.P429P	AC068134.8_ENST00000441266.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	429						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GCGCCCGGCCGGATGTTACCG	0.697000													9	63					0	0	0.008291	0	0
CCNA1	8900	broad.mit.edu	37	13	37011885	37011885	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:37011885G>A	ENST00000418263.1	+	3	764	c.414G>A	c.(412-414)atG>atA	p.M138I	CCNA1_ENST00000255465.4_Missense_Mutation_p.M139I|CCNA1_ENST00000440264.1_Missense_Mutation_p.M95I|CCNA1_ENST00000449823.1_Missense_Mutation_p.M95I	NM_001111045.1|NM_003914.3	NP_001104515.1|NP_003905.1	P78396	CCNA1_HUMAN	cyclin A1	139					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	35		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		ACATCTACATGGATGAACTAG	0.527000													14	55					0	0	0.001855	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94913446	94913446	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:94913446A>T	ENST00000289495.5	+	15	3509	c.3293A>T	c.(3292-3294)tAt>tTt	p.Y1098F	PPP1R9A_ENST00000433881.1_Intron|PPP1R9A_ENST00000340694.4_Intron|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.Y1116F|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.Y1116F|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.Y1138F	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	889						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAAGGATCCTATTCCTTCAGG	0.483000										HNSCC(28;0.073)			16	43					0	0	0.004990	0	0
MUC16	94025	broad.mit.edu	37	19	9057290	9057290	+	Silent	SNP	T	T	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9057290T>G	ENST00000397910.4	-	3	30359	c.30156A>C	c.(30154-30156)tcA>tcC	p.S10052S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10054	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGGTGAGGAGTGAAGTCACAG	0.483000													9	37					0	0	0.006214	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6064089	6064089	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:6064089G>T	ENST00000409021.3	-	10	1959	c.1510C>A	c.(1510-1512)Ctg>Atg	p.L504M	JAKMIP1_ENST00000282924.5_Missense_Mutation_p.L504M|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.L319M|JAKMIP1_ENST00000410077.2_Missense_Mutation_p.L339M|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.L504M	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	504	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCCTGGAGCAGGGCGTAGGCG	0.667000													11	79					9.70103e-10	1.01013e-09	0.008291	1	0
JMJD6	23210	broad.mit.edu	37	17	74714856	74714856	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:74714856G>A	ENST00000585429.1	-	5	1055	c.1028C>T	c.(1027-1029)cCt>cTt	p.P343L	JMJD6_ENST00000445478.2_Silent_p.T389T|JMJD6_ENST00000397625.4_Silent_p.T389T			Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6	0	Ser-rich.				mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			endometrium(2)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|skin(2)	16						CGTCCTGGGAGGTGGTGTCCC	0.627000													5	62					0	0	0.001168	0	0
HCRTR1	3061	broad.mit.edu	37	1	32086541	32086541	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:32086541G>A	ENST00000403528.2	+	5	861	c.476G>A	c.(475-477)cGg>cAg	p.R159Q	HCRTR1_ENST00000468521.1_3'UTR|HCRTR1_ENST00000373705.1_Missense_Mutation_p.R159Q|HCRTR1_ENST00000373706.5_Missense_Mutation_p.R159Q	NM_001525.2	NP_001516.2	O43613	OX1R_HUMAN	hypocretin (orexin) receptor 1	159					feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				breast(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	7		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		AGCACAGCCCGGCGGGCCCGT	0.617000													14	54					0	0	0.003163	0	0
CYP2D6	1565	broad.mit.edu	37	22	42523897	42523897	+	Missense_Mutation	SNP	G	G	A	rs1135830		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:42523897G>A	ENST00000360608.5	-	6	1046	c.932C>T	c.(931-933)tCg>tTg	p.S311L	NDUFA6-AS1_ENST00000439129.1_RNA|CYP2D6_ENST00000389970.3_Missense_Mutation_p.S311L|CYP2D6_ENST00000359033.4_Missense_Mutation_p.S260L|NDUFA6-AS1_ENST00000416037.1_RNA	NM_000106.5	NP_000097.3	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	311							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CAGCGTGGTCGAGGTGGTCAC	0.617000													19	75					0	0	0.008871	0	0
KIR3DL3	115653	broad.mit.edu	37	19	55246796	55246796	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:55246796C>T	ENST00000291860.1	+	6	1044	c.1026C>T	c.(1024-1026)ctC>ctT	p.L342L	KIR3DL1_ENST00000541392.1_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron	NM_153443.3	NP_703144.2	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3	342						integral to membrane|plasma membrane	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(3)|prostate(1)|skin(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		TCTTCTTTCTCCTTCATCGCT	0.522000													14	45					0	0	0.001855	0	0
XKR9	389668	broad.mit.edu	37	8	71646537	71646537	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:71646537C>T	ENST00000408926.3	+	5	1534	c.1000C>T	c.(1000-1002)Ctt>Ttt	p.L334F	XKR9_ENST00000520030.1_Missense_Mutation_p.L334F|XKR9_ENST00000520273.1_Intron	NM_001011720.1	NP_001011720.1	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related family, member 9	334						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(4)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			TCTTGGAATTCTTTTTCTTAT	0.323000													6	23					0	0	0.001168	0	0
SCN10A	6336	broad.mit.edu	37	3	38766673	38766673	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:38766673G>A	ENST00000449082.2	-	17	3219	c.3220C>T	c.(3220-3222)Cct>Tct	p.P1074S		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1074					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ACCTCAGCAGGGACCTGAGGA	0.607000													9	37					0	0	0.010729	0	0
ZFAT	57623	broad.mit.edu	37	8	135614828	135614828	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:135614828G>A	ENST00000520727.1	-	7	1397	c.1098C>T	c.(1096-1098)gaC>gaT	p.D366D	ZFAT_ENST00000520214.1_Silent_p.D366D|ZFAT_ENST00000429442.2_Silent_p.D366D|ZFAT_ENST00000523399.1_Silent_p.D316D|ZFAT_ENST00000377838.3_Silent_p.D378D|ZFAT_ENST00000520356.1_Silent_p.D366D	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	378					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGTCCTGTGGGTCATGCGCGT	0.557000													18	61					0	0	0.010504	0	0
TTN	7273	broad.mit.edu	37	2	179648473	179648473	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:179648473G>A	ENST00000589042.1	-	17	3039	c.2815C>T	c.(2815-2817)Cct>Tct	p.P939S	TTN_ENST00000342992.6_Missense_Mutation_p.P939S|TTN_ENST00000342175.6_Missense_Mutation_p.P893S|TTN_ENST00000460472.2_Missense_Mutation_p.P893S|TTN_ENST00000591111.1_Missense_Mutation_p.P939S|TTN_ENST00000360870.5_Missense_Mutation_p.P939S|TTN_ENST00000359218.5_Missense_Mutation_p.P893S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	939							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAGTAACAGGAATTTCAACA	0.348000													7	50					0	0	0.004482	0	0
POLR2A	5430	broad.mit.edu	37	17	7400791	7400791	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:7400791C>T	ENST00000322644.6	+	6	1335	c.936C>T	c.(934-936)ttC>ttT	p.F312F	POLR2A_ENST00000572844.1_Silent_p.F312F	NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	312					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				TCCTCCAGTTCCATGTGGCCA	0.592000													11	55					0	0	0.002450	0	0
ZNF846	162993	broad.mit.edu	37	19	9870588	9870588	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9870588G>A	ENST00000397902.2	-	5	673	c.260C>T	c.(259-261)tCc>tTc	p.S87F	ZNF846_ENST00000592859.1_Intron|ZNF846_ENST00000586293.1_Intron|ZNF846_ENST00000588267.1_Intron	NM_001077624.1	NP_001071092.1	Q147U1	ZN846_HUMAN	zinc finger protein 846	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22						CAGCAGTGGGGAGCCTTTGGT	0.398000													12	42					0	0	0.001855	0	0
NMD3	51068	broad.mit.edu	37	3	160945082	160945082	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:160945082G>A	ENST00000460469.1	+	3	682	c.227G>A	c.(226-228)aGg>aAg	p.R76K	NMD3_ENST00000351193.2_Missense_Mutation_p.R76K|NMD3_ENST00000472947.1_Missense_Mutation_p.R76K|NMD3_ENST00000478160.1_3'UTR			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	76					protein transport	cytoplasm|nucleolus|nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TTAGAATCCAGGGAACTTCTT	0.358000													7	41					0	0	0.003080	0	0
KCNK1	3775	broad.mit.edu	37	1	233767029	233767029	+	Translation_Start_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:233767029G>A	ENST00000366620.1	+	3	633	c.3G>A	c.(1-3)atG>atA	p.M1I	KCNK1_ENST00000472190.1_Intron|KCNK1_ENST00000366621.3_Intron			O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	0						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	ATCAAGATATGAAAGGTTGTC	0.448000													6	10					0	0	0.001984	0	0
GLB1L	79411	broad.mit.edu	37	2	220102567	220102567	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:220102567G>A	ENST00000295759.7	-	15	1767	c.1454C>T	c.(1453-1455)tCt>tTt	p.S485F	GLB1L_ENST00000497855.1_5'UTR|GLB1L_ENST00000409640.1_Missense_Mutation_p.S395F|GLB1L_ENST00000356283.3_Missense_Mutation_p.S395F|GLB1L_ENST00000392089.2_Missense_Mutation_p.S485F			Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like	485					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACTGCTGTTAGACCCAAAGCT	0.443000													10	66					0	0	0.008291	0	0
DSG4	147409	broad.mit.edu	37	18	28966764	28966764	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:28966764G>A	ENST00000359747.4	+	3	227	c.198G>A	c.(196-198)aaG>aaA	p.K66K	RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Silent_p.K66K|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	66	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACAACTCGAAGAGGAACCCCA	0.453000													5	49					0	0	0.000602	0	0
UNC79	57578	broad.mit.edu	37	14	94046605	94046605	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:94046605C>T	ENST00000553484.1	+	19	2698	c.2544C>T	c.(2542-2544)acC>acT	p.T848T	UNC79_ENST00000555664.1_Silent_p.T848T|UNC79_ENST00000393151.2_Silent_p.T848T|UNC79_ENST00000256339.4_Silent_p.T671T			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	848						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GATCCCACACCTGCCAGAAGG	0.453000													29	50					0	0	0.012213	0	0
SLC30A3	7781	broad.mit.edu	37	2	27481129	27481129	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:27481129G>A	ENST00000233535.4	-	3	676	c.324C>T	c.(322-324)caC>caT	p.H108H	SLC30A3_ENST00000447008.2_Silent_p.H103H	NM_003459.4	NP_003450.2	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter), member 3	108					regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|pancreas(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGCCAGCAAGTGGGCTGCAT	0.577000													10	37					0	0	0.013537	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955953	18955953	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:18955953G>A	ENST00000302797.3	-	1	603	c.379C>T	c.(379-381)Ccc>Tcc	p.P127S	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	127					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.P127A(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TACCAGATGGGCCACAGGACG	0.592000													16	85					0	0	0.006122	0	0
SPICE1	152185	broad.mit.edu	37	3	113175994	113175994	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:113175994G>A	ENST00000295872.4	-	13	1905	c.1646C>T	c.(1645-1647)cCt>cTt	p.P549L		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	549					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						GTCCTGAAGAGGAGAGAATTT	0.363000													7	24					0	0	0.003080	0	0
GPR115	221393	broad.mit.edu	37	6	47682440	47682440	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:47682440C>T	ENST00000283303.2	+	6	1717	c.1459C>T	c.(1459-1461)Ctg>Ttg	p.L487L	GPR115_ENST00000327753.3_Silent_p.L487L|GPR115_ENST00000371220.1_Silent_p.L544L	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	487					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CTACCTCTCTCTGTTTTTCTG	0.408000													28	198					0	0	0.007291	0	0
KIAA1804	84451	broad.mit.edu	37	1	233514947	233514947	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:233514947C>T	ENST00000366624.3	+	9	2456	c.2195C>T	c.(2194-2196)tCg>tTg	p.S732L	MLK4_ENST00000366622.1_Missense_Mutation_p.S178L	NM_032435.2	NP_115811.2																					CTTCTGGCATCGGTGGCTCTG	0.517000													13	46					0	0	0.001855	0	0
SYT17	51760	broad.mit.edu	37	16	19236127	19236127	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:19236127G>A	ENST00000562034.1	+	5	4810	c.1012G>A	c.(1012-1014)Gaa>Aaa	p.E338K	SYT17_ENST00000355377.2_Missense_Mutation_p.E399K|SYT17_ENST00000562711.2_Missense_Mutation_p.E395K|SYT17_ENST00000568433.1_Missense_Mutation_p.E93K|SYT17_ENST00000568115.1_Missense_Mutation_p.E338K			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	399	C2 2.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						AGTTCCCCAAGAAGAACTGGA	0.458000													17	84					0	0	0.007413	0	0
FAM83C	128876	broad.mit.edu	37	20	33874510	33874510	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:33874510C>T	ENST00000374408.3	-	4	2168	c.2072G>A	c.(2071-2073)gGg>gAg	p.G691E		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	691										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CTGCCTGGCCCCGTGCAACTG	0.612000													17	105					0	0	0.004990	0	0
GRM3	2913	broad.mit.edu	37	7	86479772	86479772	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:86479772C>T	ENST00000394720.2	+	4	1582	c.1405C>T	c.(1405-1407)Cct>Tct	p.P469S	GRM3_ENST00000439827.1_Missense_Mutation_p.P471S|GRM3_ENST00000361669.2_Silent_p.I826I|GRM3_ENST00000536043.1_Silent_p.I698I|GRM3_ENST00000546348.1_Silent_p.I418I			Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	0					synaptic transmission	integral to plasma membrane		p.L827V(1)|p.I826I(1)		NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TTCACATCATCCTGTTTCAAC	0.488000													9	44					0	0	0.006214	0	0
FGB	2244	broad.mit.edu	37	4	155491713	155491713	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:155491713G>A	ENST00000302068.4	+	8	1450	c.1387G>A	c.(1387-1389)Gat>Aat	p.D463N	FGB_ENST00000509493.1_Missense_Mutation_p.D244N|FGB_ENST00000502545.1_3'UTR	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	463	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TGGCACAGATGATGGTGTAGT	0.483000													9	50					0	0	0.006214	0	0
NXF1	10482	broad.mit.edu	37	11	62563934	62563934	+	Silent	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:62563934G>T	ENST00000532297.1	-	15	1913	c.1284C>A	c.(1282-1284)gcC>gcA	p.A428A	NXF1_ENST00000531709.2_3'UTR|NXF1_ENST00000294172.2_Silent_p.A428A			Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1	428	NTF2.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ATACTAACCGGGCAGGGTTCT	0.557000													21	65					7.92952e-12	8.28108e-12	0.003954	1	0
SLC37A2	219855	broad.mit.edu	37	11	124947412	124947412	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:124947412G>A	ENST00000403796.2	+	4	603	c.302G>A	c.(301-303)gGc>gAc	p.G101D	SLC37A2_ENST00000407458.1_Missense_Mutation_p.G101D|SLC37A2_ENST00000308074.4_Missense_Mutation_p.G101D|SLC37A2_ENST00000298280.5_Missense_Mutation_p.G101D	NM_001145290.1	NP_001138762.1	Q8TED4	SPX2_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 2	101					carbohydrate transport|transmembrane transport	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	27	all_hematologic(175;0.215)	Breast(109;0.012)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.152)|all_lung(97;0.159)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0384)		TATGCCATCGGCATGTTCATC	0.527000													11	39					0	0	0.008291	0	0
SCN7A	6332	broad.mit.edu	37	2	167262763	167262763	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:167262763C>T	ENST00000409855.1	-	25	4502	c.4376G>A	c.(4375-4377)gGg>gAg	p.G1459E		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	1459					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						AACTTGAGTCCCAGGGTTAAT	0.373000													14	69					0	0	0.003163	0	0
COL4A1	1282	broad.mit.edu	37	13	110830467	110830467	+	Missense_Mutation	SNP	G	G	A	rs145861489		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:110830467G>A	ENST00000375820.4	-	32	2691	c.2570C>T	c.(2569-2571)tCg>tTg	p.S857L		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	857	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AGGGAGCCCCGACTGTCCCGT	0.552000													52	111					0	0	0.014410	0	0
CTNNA2	1496	broad.mit.edu	37	2	80101409	80101409	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:80101409G>A	ENST00000466387.1	+	10	1517	c.793G>A	c.(793-795)Gac>Aac	p.D265N	CTNNA2_ENST00000541047.1_Missense_Mutation_p.D265N|CTNNA2_ENST00000402739.4_Missense_Mutation_p.D265N|CTNNA2_ENST00000540488.1_Missense_Mutation_p.D265N|CTNNA2_ENST00000361291.4_Missense_Mutation_p.D299N|CTNNA2_ENST00000496558.1_Missense_Mutation_p.D265N			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	265					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CTCGCCCACTGACGAAGCCAA	0.582000													17	56					0	0	0.004007	0	0
PKP2	5318	broad.mit.edu	37	12	33031163	33031163	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:33031163G>A	ENST00000340811.4	-	3	759	c.651C>T	c.(649-651)taC>taT	p.Y217Y	PKP2_ENST00000070846.6_Silent_p.Y217Y	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	217					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					ACTGTCTGTGGTATGTGTCAA	0.632000													11	58					0	0	0.010729	0	0
TNXB	7148	broad.mit.edu	37	6	32038124	32038124	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:32038124G>A	ENST00000375244.3	-	14	5259	c.5058C>T	c.(5056-5058)acC>acT	p.T1686T	TNXB_ENST00000375247.2_Silent_p.T1686T			P22105	TENX_HUMAN	tenascin XB	1768	Fibronectin type-III 9.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GTGAGTCTGGGGTGGGGTCTG	0.617000													64	232					0	0	0.014410	0	0
SRSF5	6430	broad.mit.edu	37	14	70238028	70238028	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:70238028C>T	ENST00000553521.1	+	9	2122	c.669C>T	c.(667-669)agC>agT	p.S223S	SRSF5_ENST00000553635.1_Silent_p.S220S|SRSF5_ENST00000394366.2_Silent_p.S223S|SRSF5_ENST00000557154.1_Silent_p.S223S|SRSF5_ENST00000556587.1_3'UTR			Q13243	SRSF5_HUMAN	serine/arginine-rich splicing factor 5	223	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding			large_intestine(1)|liver(1)	2						GGAGCCGGAGCCGGAGCAAGT	0.562000													47	87					0	0	0.013114	0	0
PSG5	5673	broad.mit.edu	37	19	43689011	43689011	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:43689011C>T	ENST00000404580.1	-	2	441	c.353G>A	c.(352-354)gGa>gAa	p.G118E	PSG5_ENST00000599812.1_Missense_Mutation_p.G118E|PSG5_ENST00000407568.1_Missense_Mutation_p.G118E|PSG5_ENST00000407356.1_Missense_Mutation_p.G118E|PSG5_ENST00000366175.3_Missense_Mutation_p.G118E|PSG5_ENST00000342951.6_Missense_Mutation_p.G118E|PSG5_ENST00000401992.1_5'UTR			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	118	Ig-like V-type.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				GGTGTAGGATCCTGCGTCTTC	0.448000													62	257					0	0	0.014410	0	0
PBX1	5087	broad.mit.edu	37	1	164769111	164769111	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:164769111G>A	ENST00000420696.2	+	4	874	c.686G>A	c.(685-687)cGa>cAa	p.R229Q	PBX1_ENST00000540236.1_Missense_Mutation_p.R229Q|PBX1_ENST00000367897.1_Missense_Mutation_p.R229Q|PBX1_ENST00000560641.1_Missense_Mutation_p.R124Q|PBX1_ENST00000540246.1_Missense_Mutation_p.R124Q|PBX1_ENST00000559240.1_Missense_Mutation_p.R229Q|PBX1_ENST00000401534.1_Missense_Mutation_p.R229Q	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	229					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						CTGCGTTCCCGATTTCTGGAT	0.617000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								7	24					0	0	0.008291	0	0
NWD1	284434	broad.mit.edu	37	19	16918858	16918858	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:16918858G>A	ENST00000524140.2	+	18	4616	c.4198G>A	c.(4198-4200)Gag>Aag	p.E1400K	NWD1_ENST00000552788.1_Missense_Mutation_p.E1400K|NWD1_ENST00000549814.1_Missense_Mutation_p.E1358K|NWD1_ENST00000379808.3_Missense_Mutation_p.E1400K|NWD1_ENST00000339803.6_Missense_Mutation_p.E1265K|NWD1_ENST00000523826.1_Missense_Mutation_p.E1194K	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1400							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CAGCCACAAGGAGCAGCTGGT	0.587000													12	102					0	0	0.001855	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596509	24596509	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:24596509C>T	ENST00000535378.1	-	4	1008	c.366G>A	c.(364-366)ggG>ggA	p.G122G	KIAA0319_ENST00000378214.3_Silent_p.G131G|KIAA0319_ENST00000543707.1_Silent_p.G131G|KIAA0319_ENST00000430948.2_Silent_p.G86G|KIAA0319_ENST00000537886.1_Silent_p.G131G	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	131					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						CAGGTGAGTCCCCCCAGATCC	0.552000													6	65					0	0	0.001984	0	0
PEG3	5178	broad.mit.edu	37	19	57333026	57333026	+	Missense_Mutation	SNP	C	C	T	rs138565582	byFrequency	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:57333026C>T	ENST00000326441.9	-	7	1025	c.662G>A	c.(661-663)cGa>cAa	p.R221Q	PEG3_ENST00000423103.2_Missense_Mutation_p.R221Q|ZIM2_ENST00000601070.1_Missense_Mutation_p.R96Q|ZIM2_ENST00000593711.1_Missense_Mutation_p.R96Q|ZIM2_ENST00000599935.1_Missense_Mutation_p.R96Q|PEG3_ENST00000598410.1_Missense_Mutation_p.R96Q|ZIM2_ENST00000221722.5_Missense_Mutation_p.R96Q|ZIM2_ENST00000391708.3_Missense_Mutation_p.R96Q|PEG3_ENST00000593695.1_Missense_Mutation_p.R95Q	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	221					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TACCTGAGATCGGGACTCATA	0.527000													26	114					0	0	0.005443	0	0
PAK7	57144	broad.mit.edu	37	20	9538273	9538273	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:9538273G>A	ENST00000378429.3	-	8	2271	c.1725C>T	c.(1723-1725)ctC>ctT	p.L575L	PAK7_ENST00000378423.1_Silent_p.L575L|PAK7_ENST00000353224.5_Silent_p.L575L	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	575	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			CGCTTGTCAGGAGGATGGAGT	0.448000													12	45					0	0	0.002450	0	0
COL28A1	340267	broad.mit.edu	37	7	7477065	7477065	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:7477065C>T	ENST00000399429.3	-	22	1891	c.1751G>A	c.(1750-1752)gGa>gAa	p.G584E		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	584					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TCCAGGCATTCCAAAAGGGCC	0.388000													13	37					0	0	0.004990	0	0
SHMT2	6472	broad.mit.edu	37	12	57628078	57628078	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:57628078C>T	ENST00000328923.3	+	12	1901	c.1449C>T	c.(1447-1449)gcC>gcT	p.A483A	SHMT2_ENST00000449049.3_Silent_p.A462A|SHMT2_ENST00000414700.3_Silent_p.A462A|SHMT2_ENST00000393827.4_Silent_p.A387A|SHMT2_ENST00000557487.1_Silent_p.A473A|SHMT2_ENST00000553474.1_Silent_p.A462A	NM_001166356.1|NM_005412.5	NP_001159828.1|NP_005403.2	P34897	GLYM_HUMAN	serine hydroxymethyltransferase 2 (mitochondrial)	483						microtubule cytoskeleton|mitochondrial nucleoid	glycine hydroxymethyltransferase activity|methyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15					Glycine(DB00145)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	AGCGTCTGGCCAACCTCAGGC	0.532000													17	107					0	0	0.004990	0	0
PTPRK	5796	broad.mit.edu	37	6	128302403	128302403	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:128302403G>A	ENST00000368227.3	-	26	3986	c.3620C>T	c.(3619-3621)gCt>gTt	p.A1207V	PTPRK_ENST00000368215.3_Missense_Mutation_p.A1189V|PTPRK_ENST00000368226.4_Missense_Mutation_p.A1190V|PTPRK_ENST00000368213.5_Missense_Mutation_p.A1196V|PTPRK_ENST00000532331.1_Missense_Mutation_p.A1212V|PTPRK_ENST00000368210.3_Missense_Mutation_p.A1208V|PTPRK_ENST00000368207.3_Missense_Mutation_p.A1222V			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1189	Tyrosine-protein phosphatase 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GCAGTCTTCAGCTTGTAGTCG	0.428000													11	19					0	0	0.008291	0	0
CNOT4	4850	broad.mit.edu	37	7	135106988	135106988	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:135106988G>A	ENST00000428680.2	-	3	568	c.289C>T	c.(289-291)Cgc>Tgc	p.R97C	CNOT4_ENST00000423368.2_Missense_Mutation_p.R97C|CNOT4_ENST00000414802.1_Missense_Mutation_p.R97C|CNOT4_ENST00000356162.4_Missense_Mutation_p.R97C|CNOT4_ENST00000361528.4_Missense_Mutation_p.R97C|CNOT4_ENST00000541284.1_Missense_Mutation_p.R97C|CNOT4_ENST00000315544.5_Missense_Mutation_p.R97C|CNOT4_ENST00000451834.1_Missense_Mutation_p.R97C	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	97					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						AAATGTTTGCGATTTTCTGAT	0.398000													14	57					0	0	0.004990	0	0
CD163	9332	broad.mit.edu	37	12	7640083	7640083	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:7640083C>T	ENST00000359156.4	-	8	2124	c.1922G>A	c.(1921-1923)gGa>gAa	p.G641E	CD163_ENST00000396620.3_Missense_Mutation_p.G674E|CD163_ENST00000432237.2_Missense_Mutation_p.G641E|CD163_ENST00000541972.1_Missense_Mutation_p.G629E	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	641	SRCR 6.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CTGACCATTTCCTTTTCCAAA	0.478000													27	94					0	0	0.006320	0	0
VTCN1	79679	broad.mit.edu	37	1	117695729	117695729	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:117695729C>T	ENST00000369458.3	-	4	786	c.708G>A	c.(706-708)ggG>ggA	p.G236G	VTCN1_ENST00000359008.4_Silent_p.G239G|VTCN1_ENST00000328189.3_Silent_p.G120G|VTCN1_ENST00000539893.1_Silent_p.G141G	NM_024626.3	NP_078902.2	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation inhibitor 1	236	Ig-like V-type 2.					integral to membrane|plasma membrane				large_intestine(7)|lung(4)|upper_aerodigestive_tract(1)	12	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		CTTTGATATCCCCTGTTGCTT	0.358000													22	92					0	0	0.002780	0	0
NFYA	4800	broad.mit.edu	37	6	41059431	41059431	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:41059431A>G	ENST00000341376.6	+	7	913	c.712A>G	c.(712-714)Atg>Gtg	p.M238V	NFYA_ENST00000353205.5_Missense_Mutation_p.M209V|OARD1_ENST00000480585.1_Intron	NM_002505.4	NP_002496.1	P23511	NFYA_HUMAN	nuclear transcription factor Y, alpha	238					transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(2)|urinary_tract(1)	9	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGGGATGGTCATGGTAAGAAA	0.423000													19	101					0	0	0.014323	0	0
ZPLD1	131368	broad.mit.edu	37	3	102153975	102153975	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:102153975C>T	ENST00000306176.1	+	1	117	c.17C>T	c.(16-18)tCc>tTc	p.S6F	ZPLD1_ENST00000466937.1_5'UTR|ZPLD1_ENST00000491959.1_Intron	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	0						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						CTCAGGTTTTCCATGTGCAGG	0.378000													8	38					0	0	0.010729	0	0
COQ3	51805	broad.mit.edu	37	6	99823983	99823983	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:99823983T>C	ENST00000254759.3	-	5	586	c.562A>G	c.(562-564)Aaa>Gaa	p.K188E	COQ3_ENST00000369240.1_Intron|COQ3_ENST00000369242.1_Intron	NM_017421.3	NP_059117.3	Q9NZJ6	COQ3_HUMAN	coenzyme Q3 methyltransferase	188					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			cervix(1)|lung(5)|upper_aerodigestive_tract(2)	8		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		TCAAATGATTTATGGCATTGT	0.428000													12	80					0	0	0.001855	0	0
COBLL1	22837	broad.mit.edu	37	2	165578729	165578729	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:165578729G>A	ENST00000375458.2	-	6	1073	c.852C>T	c.(850-852)acC>acT	p.T284T	COBLL1_ENST00000194871.6_Silent_p.T350T|COBLL1_ENST00000342193.4_Silent_p.T284T|COBLL1_ENST00000409184.3_Silent_p.T322T|COBLL1_ENST00000491126.2_Intron|COBLL1_ENST00000392717.2_Silent_p.T322T	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	322										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						CCGACGGCAGGGTGTTGGAAA	0.537000													8	49					0	0	0.003080	0	0
COCH	1690	broad.mit.edu	37	14	31354664	31354664	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:31354664C>T	ENST00000460581.2	+	8	1008	c.462C>T	c.(460-462)atC>atT	p.I154I	COCH_ENST00000396618.3_Silent_p.I266I|COCH_ENST00000216361.4_Silent_p.I266I|RP11-829H16.3_ENST00000555108.1_RNA|COCH_ENST00000475087.1_Silent_p.I266I|COCH_ENST00000382493.4_Silent_p.I117I			O43405	COCH_HUMAN	cochlin	266					sensory perception of sound	proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|pancreas(1)|skin(3)	19	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		GAAAAGGGATCCCCAAAGTGG	0.408000													13	55					0	0	0.001855	0	0
SYT6	148281	broad.mit.edu	37	1	114646258	114646258	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:114646258C>T	ENST00000393296.1	-	4	1234	c.1157G>A	c.(1156-1158)cGg>cAg	p.R386Q	SYT6_ENST00000369547.1_Missense_Mutation_p.R301Q			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	386	C2 2.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTGAGGTTCCGACACTTAAT	0.537000													9	69					0	0	0.004482	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26045748	26045748	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:26045748A>T	ENST00000540144.1	+	1	110	c.110A>T	c.(109-111)aAg>aTg	p.K37M		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	37					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						GGTGGCGTGAAGAAACCTCAT	0.632000													14	68					0	0	0.001855	0	0
PMFBP1	83449	broad.mit.edu	37	16	72158669	72158669	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:72158669C>T	ENST00000537465.1	-	17	2759	c.2601G>A	c.(2599-2601)aaG>aaA	p.K867K	PMFBP1_ENST00000537792.1_Silent_p.K28K|PMFBP1_ENST00000355636.6_Silent_p.K717K|PMFBP1_ENST00000237353.10_Silent_p.K862K			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	867										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TGCCCACCTCCTTATCGTCCT	0.577000											OREG0023927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	52					0	0	0.002780	0	0
DUSP26	78986	broad.mit.edu	37	8	33449668	33449668	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:33449668G>A	ENST00000256261.4	-	4	1016	c.499C>T	c.(499-501)Ctc>Ttc	p.L167F	DUSP26_ENST00000523956.1_Missense_Mutation_p.L167F	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	167	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		TACAGCATGAGGTAGGCCAGT	0.587000													9	26					0	0	0.004482	0	0
CCR6	1235	broad.mit.edu	37	6	167550381	167550381	+	Silent	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:167550381T>C	ENST00000341935.5	+	3	1215	c.663T>C	c.(661-663)ttT>ttC	p.F221F	CCR6_ENST00000400926.2_Silent_p.F221F|CCR6_ENST00000349984.4_Silent_p.F221F	NM_031409.3	NP_113597.2	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	221					cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	14		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		AGCTACTCTTTGGTTTCTTTA	0.458000													13	94					0	0	0.002450	0	0
DNAH7	56171	broad.mit.edu	37	2	196729392	196729392	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:196729392G>A	ENST00000312428.6	-	41	7087	c.6987C>T	c.(6985-6987)atC>atT	p.I2329I		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2329	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GCTGCTTCAGGATCCTGGAAA	0.453000													12	31					0	0	0.010729	0	0
VWA5A	4013	broad.mit.edu	37	11	124013234	124013234	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:124013234C>T	ENST00000456829.2	+	17	2360	c.2109C>T	c.(2107-2109)atC>atT	p.I703I	VWA5A_ENST00000392748.1_Silent_p.I703I|VWA5A_ENST00000360334.4_3'UTR	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	703										autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						TAGCCAAGATCCTAGGTATGA	0.423000													19	67					0	0	0.008871	0	0
ZSCAN31	64288	broad.mit.edu	37	6	28297280	28297280	+	Silent	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:28297280G>T	ENST00000414429.1	-	6	1084	c.181C>A	c.(181-183)Cga>Aga	p.R61R	ZSCAN31_ENST00000344279.6_Silent_p.R61R|ZSCAN31_ENST00000396838.2_Silent_p.R61R|ZSCAN31_ENST00000446474.1_Intron|ZSCAN31_ENST00000439158.1_Silent_p.R61R					zinc finger and SCAN domain containing 31																		CAGAGTTCTCGGAGCCGGCTC	0.522000													6	263					8.12818e-05	8.40573e-05	0.001984	1	0
PCDH19	57526	broad.mit.edu	37	X	99662260	99662260	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:99662260C>T	ENST00000373034.4	-	1	3011	c.1336G>A	c.(1336-1338)Gaa>Aaa	p.E446K	PCDH19_ENST00000420881.2_Missense_Mutation_p.E446K|PCDH19_ENST00000255531.7_Missense_Mutation_p.E446K	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	446	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						TTGTCATTTTCGTCAGTGATG	0.572000													25	47					0	0	0.003330	0	0
AGFG2	3268	broad.mit.edu	37	7	100153358	100153358	+	Splice_Site	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:100153358G>A	ENST00000300176.4	+	6	999	c.877_splice	c.e6+1	p.G293_splice	AGFG2_ENST00000262935.4_3'UTR|AGFG2_ENST00000474713.1_3'UTR	NM_006076.4	NP_006067.3	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	293					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AACTCCTGCAGGTAAACTCTG	0.507000													17	104					0	0	0.006122	0	0
HNF4G	3174	broad.mit.edu	37	8	76456189	76456189	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:76456189C>T	ENST00000396423.2	+	2	356	c.232C>T	c.(232-234)Cgt>Tgt	p.R78C	HNF4G_ENST00000354370.1_Missense_Mutation_p.R41C	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	41					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			ACGCAGCATTCGTAAGAGTCA	0.438000													7	53					0	0	0.003080	0	0
SCN5A	6331	broad.mit.edu	37	3	38601884	38601884	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:38601884G>A	ENST00000413689.1	-	23	4192	c.3999C>T	c.(3997-3999)tcC>tcT	p.S1333S	SCN5A_ENST00000414099.2_Silent_p.S1333S|SCN5A_ENST00000333535.4_Silent_p.S1333S|SCN5A_ENST00000455624.2_Silent_p.S1332S|SCN5A_ENST00000451551.2_Silent_p.S1279S|SCN5A_ENST00000423572.2_Silent_p.S1332S|SCN5A_ENST00000425664.1_Silent_p.S1333S|SCN5A_ENST00000450102.2_Silent_p.S1279S|SCN5A_ENST00000449557.2_Silent_p.S1279S|SCN5A_ENST00000443581.1_Silent_p.S1332S	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1333			S -> Y (in LQT3 and SIDS).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CGTTCATGATGGACGGGATGG	0.572000													3	32					0	0	0.004672	0	0
KDR	3791	broad.mit.edu	37	4	55984850	55984850	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:55984850C>T	ENST00000263923.4	-	3	574	c.279G>A	c.(277-279)gtG>gtA	p.V93V		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	93	Ig-like C2-type 1.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CATTTCCGATCACTTTTGGAA	0.468000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			14	41					0	0	0.003163	0	0
SIAH3	283514	broad.mit.edu	37	13	46358027	46358027	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr13:46358027G>A	ENST00000400405.2	-	2	407	c.301C>T	c.(301-303)Ccg>Tcg	p.P101S		NM_198849.2	NP_942146.2	Q8IW03	SIAH3_HUMAN	siah E3 ubiquitin protein ligase family member 3	101					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			large_intestine(3)|lung(7)|ovary(1)|skin(1)	12						GGCGTCACCGGGTTGGCGTGC	0.682000													31	44					0	0	0.009535	0	0
FLG	2312	broad.mit.edu	37	1	152277785	152277785	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:152277785T>C	ENST00000368799.1	-	3	9612	c.9577A>G	c.(9577-9579)Aga>Gga	p.R3193G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3193	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGAGTGTCTAGAGATGTCG	0.542000									Ichthyosis				39	156					0	0	0.009718	0	0
BRS3	680	broad.mit.edu	37	X	135572395	135572395	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:135572395C>T	ENST00000370648.3	+	2	766	c.538C>T	c.(538-540)Cta>Tta	p.L180L		NM_001727.1	NP_001718.1	P32247	BRS3_HUMAN	bombesin-like receptor 3	180					adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(1)	23	Acute lymphoblastic leukemia(192;0.000127)					GATATTTGCTCTACCTGAGGC	0.418000													15	34					0	0	0.003163	0	0
FBN3	84467	broad.mit.edu	37	19	8174261	8174261	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:8174261C>T	ENST00000600128.1	-	36	4882	c.4468G>A	c.(4468-4470)Ggg>Agg	p.G1490R	FBN3_ENST00000270509.2_Missense_Mutation_p.G1490R|FBN3_ENST00000601739.1_Missense_Mutation_p.G1490R			Q75N90	FBN3_HUMAN	fibrillin 3	1490	TB 6.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						AAACAGTTCCCGGCCCGAGTG	0.557000													14	50					0	0	0.003163	0	0
TENM4	26011	broad.mit.edu	37	11	78413134	78413134	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:78413134C>T	ENST00000278550.7	-	28	4986	c.4524G>A	c.(4522-4524)ggG>ggA	p.G1508G		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		CACTGGGGGCCCCAGCAACGA	0.468000													6	14					0	0	0.001984	0	0
SERPINB2	5055	broad.mit.edu	37	18	61570459	61570459	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr18:61570459G>A	ENST00000457692.1	+	9	1501	c.1168G>A	c.(1168-1170)Gca>Aca	p.A390T	SERPINB2_ENST00000299502.4_Missense_Mutation_p.A390T	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	390					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	ACAGTTTGTGGCAGATCATCC	0.468000													21	80					0	0	0.010504	0	0
SNHG14	104472715	broad.mit.edu	37	15	25320990	25320990	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:25320990C>T	ENST00000549804.2	+	0	1086																											TGGTCTCCTTCAGGCTGGTGG	0.463000													4	9					0	0	0.009096	0	0
NWD1	284434	broad.mit.edu	37	19	16918894	16918894	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:16918894C>T	ENST00000524140.2	+	18	4652	c.4234C>T	c.(4234-4236)Ctg>Ttg	p.L1412L	NWD1_ENST00000552788.1_Silent_p.L1412L|NWD1_ENST00000549814.1_Silent_p.L1370L|NWD1_ENST00000379808.3_Silent_p.L1412L|NWD1_ENST00000339803.6_Silent_p.L1277L|NWD1_ENST00000523826.1_Silent_p.L1206L	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1412							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGATGCCCTGCTGTGTCTCTG	0.597000													16	97					0	0	0.004007	0	0
DGKZ	8525	broad.mit.edu	37	11	46393044	46393044	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:46393044G>A	ENST00000454345.1	+	9	1339	c.1214G>A	c.(1213-1215)aGc>aAc	p.S405N	DGKZ_ENST00000318201.8_Missense_Mutation_p.S194N|DGKZ_ENST00000343674.6_Missense_Mutation_p.S233N|DGKZ_ENST00000527911.1_Missense_Mutation_p.S217N|DGKZ_ENST00000421244.2_Missense_Mutation_p.S217N|DGKZ_ENST00000395574.3_Missense_Mutation_p.S183N|DGKZ_ENST00000543978.1_Intron|DGKZ_ENST00000528615.1_5'UTR|DGKZ_ENST00000532868.2_Missense_Mutation_p.S221N|DGKZ_ENST00000456247.2_Missense_Mutation_p.S216N	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	405					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		CAGTACCACAGCAAGGTGTCC	0.706000													14	36					0	0	0.002450	0	0
COL6A2	1292	broad.mit.edu	37	21	47552145	47552145	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr21:47552145C>T	ENST00000300527.4	+	28	2843	c.2739C>T	c.(2737-2739)tcC>tcT	p.S913S		NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	913	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACCTGAACTCCTTCTCGCACG	0.672000													3	14					0	0	0.009096	0	0
AKAP9	10142	broad.mit.edu	37	7	91694579	91694579	+	Silent	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:91694579A>G	ENST00000359028.2	+	26	6273	c.6048A>G	c.(6046-6048)gaA>gaG	p.E2016E	AKAP9_ENST00000358100.2_Silent_p.E2016E|AKAP9_ENST00000491695.1_3'UTR|AKAP9_ENST00000356239.3_Silent_p.E2004E			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2016	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TAATGAAGGAAAAACTAGAAG	0.294000			T	BRAF	papillary thyroid								5	21					0	0	0.001984	0	0
SLC16A9	220963	broad.mit.edu	37	10	61414328	61414328	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:61414328G>A	ENST00000395348.3	-	5	1092	c.456C>T	c.(454-456)ttC>ttT	p.F152F	SLC16A9_ENST00000395347.1_Silent_p.F152F	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	152					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						CAGCATATATGAAAAGGCCAA	0.408000													12	64					0	0	0.013537	0	0
KRT6B	3854	broad.mit.edu	37	12	52845481	52845481	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:52845481G>A	ENST00000252252.3	-	1	429	c.382C>T	c.(382-384)Cct>Tct	p.P128S		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	128	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		GGGCACACAGGGAAGCCAGGG	0.647000													6	110					0	0	0.001168	0	0
BRINP3	339479	broad.mit.edu	37	1	190234128	190234128	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:190234128C>T	ENST00000367462.3	-	4	716	c.485G>A	c.(484-486)gGa>gAa	p.G162E	RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.G60E	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		162						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGAATCACTTCCTTCAGCTCG	0.428000													9	32					0	0	0.008291	0	0
LRP6	4040	broad.mit.edu	37	12	12279643	12279643	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:12279643A>C	ENST00000261349.4	-	20	4370	c.4294T>G	c.(4294-4296)Ttg>Gtg	p.L1432V	LRP6_ENST00000543091.1_Missense_Mutation_p.L1387V|BCL2L14_ENST00000396369.1_Intron|LRP6_ENST00000540415.1_Intron	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1432					cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				GATCCTGACAAAGAACTTGGG	0.458000													37	216					0	0	0.006230	0	0
KDM4D	55693	broad.mit.edu	37	11	94731988	94731988	+	Silent	SNP	G	G	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:94731988G>T	ENST00000335080.5	+	3	2284	c.1452G>T	c.(1450-1452)tcG>tcT	p.S484S	KDM4D_ENST00000536741.1_Silent_p.S484S	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	484					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GCACAGCTTCGGGCCCAGAAC	0.617000													3	33					0.004672	0.00481275	0.004672	1	0
GALK2	2585	broad.mit.edu	37	15	49509510	49509510	+	Splice_Site	SNP	C	C	T	rs149095986		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:49509510C>T	ENST00000327171.3	+	3	465	c.233_splice	c.e3+1	p.P78_splice	GALK2_ENST00000560031.1_Splice_Site_p.P89_splice|GALK2_ENST00000396509.2_Splice_Site_p.P65_splice|GALK2_ENST00000559454.1_Splice_Site_p.P65_splice|GALK2_ENST00000544523.1_Splice_Site_p.P65_splice|GALK2_ENST00000543495.1_5'UTR	NM_001001556.1	NP_001001556.1	Q01415	GALK2_HUMAN	galactokinase 2	89					galactose metabolic process	cytoplasm	ATP binding|galactokinase activity|N-acetylgalactosamine kinase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		all_lung(180;0.000325)		all cancers(107;3.71e-08)|GBM - Glioblastoma multiforme(94;7e-05)		CCCTTGTATCCGTGAGTATTT	0.373000													8	79					0	0	0.003080	0	0
HK3	3101	broad.mit.edu	37	5	176314054	176314054	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:176314054G>A	ENST00000292432.5	-	13	1897	c.1806C>T	c.(1804-1806)ctC>ctT	p.L602L		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	602	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AACCCAGTGGGAGGCTCTGCC	0.607000													8	24					0	0	0.003080	0	0
RP1	6101	broad.mit.edu	37	8	55534821	55534821	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:55534821G>A	ENST00000220676.1	+	3	908	c.760G>A	c.(760-762)Gga>Aga	p.G254R		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	254					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding	p.G64*(1)|p.G254*(1)		NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GTACCCCAAGGGAAATGCAAA	0.423000													11	44					0	0	0.002450	0	0
KANSL3	55683	broad.mit.edu	37	2	97271080	97271080	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:97271080G>A	ENST00000599854.1	-	15	2116	c.1649C>T	c.(1648-1650)cCt>cTt	p.P550L	KANSL3_ENST00000487070.1_5'UTR|KANSL3_ENST00000441706.2_Intron|KANSL3_ENST00000440133.1_Missense_Mutation_p.P457L|KANSL3_ENST00000431828.1_Missense_Mutation_p.P637L	NM_001115016.2	NP_001108488.1	Q9P2N6	K1310_HUMAN	KAT8 regulatory NSL complex subunit 3	663																	TCCTTGGGAAGGAGCACAAGG	0.537000													8	41					0	0	0.006214	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51397368	51397368	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:51397368C>T	ENST00000327536.5	-	1	105	c.6G>A	c.(4-6)ggG>ggA	p.G2G	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	2										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		GCCGTGGTTTCCCCATTTGGA	0.517000													15	57					0	0	0.006122	0	0
GDPD5	81544	broad.mit.edu	37	11	75150947	75150947	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:75150947G>A	ENST00000526177.1	-	11	2997	c.1119C>T	c.(1117-1119)atC>atT	p.I373I	GDPD5_ENST00000376282.3_Silent_p.I392I|GDPD5_ENST00000336898.3_Silent_p.I511I|GDPD5_ENST00000533805.1_Silent_p.I266I|GDPD5_ENST00000533784.1_Silent_p.I392I|GDPD5_ENST00000529721.1_Silent_p.I511I|GDPD5_ENST00000443276.2_3'UTR			Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain containing 5	511	GDPD.				glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity	p.I511I(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|skin(2)	20						AGATGCCCACGATGAGGGTGA	0.632000													10	60					0	0	0.008291	0	0
ME3	10873	broad.mit.edu	37	11	86157451	86157451	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:86157451C>T	ENST00000543262.1	-	13	1785	c.1459G>A	c.(1459-1461)Gga>Aga	p.G487R	RP11-317J19.1_ENST00000524610.1_RNA|ME3_ENST00000359636.2_Missense_Mutation_p.G487R|ME3_ENST00000393324.3_Missense_Mutation_p.G487R	NM_001161586.1	NP_001155058.1	Q16798	MAON_HUMAN	malic enzyme 3, NADP(+)-dependent, mitochondrial	487					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|skin(3)|stomach(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	GCATTGTTTCCCTGCCCAGGA	0.557000													13	75					0	0	0.001855	0	0
PAN2	9924	broad.mit.edu	37	12	56721365	56721365	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:56721365G>A	ENST00000425394.2	-	6	1078	c.702C>T	c.(700-702)gcC>gcT	p.A234A	PAN2_ENST00000440411.3_Silent_p.A234A|PAN2_ENST00000257931.5_Silent_p.A234A|PAN2_ENST00000548043.1_Silent_p.A234A	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	234					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TTCCTGAGAAGGCATCAAACT	0.468000													18	65					0	0	0.006122	0	0
ROR2	4920	broad.mit.edu	37	9	94485998	94485998	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:94485998C>T	ENST00000375708.3	-	9	2976	c.2778G>A	c.(2776-2778)ctG>ctA	p.L926L	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Intron	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	926					negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CACAGTCCCCCAGCAGCTCAG	0.647000													13	86					0	0	0.013537	0	0
STXBP5L	9515	broad.mit.edu	37	3	120973939	120973939	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:120973939G>A	ENST00000273666.6	+	16	1910	c.1639G>A	c.(1639-1641)Gaa>Aaa	p.E547K	STXBP5L_ENST00000497029.1_Missense_Mutation_p.E547K|STXBP5L_ENST00000492541.1_Missense_Mutation_p.E547K|STXBP5L_ENST00000472879.1_Missense_Mutation_p.E547K|STXBP5L_ENST00000471454.1_Missense_Mutation_p.E547K	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	547					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		CAGCAGACATGAAATTACAAC	0.308000													6	24					0	0	0.001168	0	0
SCN1A	6323	broad.mit.edu	37	2	166896038	166896038	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:166896038G>A	ENST00000423058.2	-	14	2501	c.2484C>T	c.(2482-2484)ttC>ttT	p.F828F	AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000303395.4_Silent_p.F828F|SCN1A_ENST00000375405.3_Silent_p.F817F|SCN1A_ENST00000409050.1_Silent_p.F800F|AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595647.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	828						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGCCTTCTTGGAAATAATAGT	0.373000													10	33					0	0	0.008291	0	0
GAS2L2	246176	broad.mit.edu	37	17	34079577	34079577	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:34079577G>A	ENST00000254466.6	-	1	320	c.293C>T	c.(292-294)tCc>tTc	p.S98F	GAS2L2_ENST00000587565.1_Missense_Mutation_p.S98F	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	98	CH.				cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCCATTGCAGGAGACCCCGAC	0.612000													24	97					0	0	0.003330	0	0
YLPM1	56252	broad.mit.edu	37	14	75266069	75266069	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:75266069C>T	ENST00000325680.7	+	5	4193	c.4069C>T	c.(4069-4071)Cga>Tga	p.R1357*	YLPM1_ENST00000552421.1_Intron|YLPM1_ENST00000238571.3_Nonsense_Mutation_p.R1162*	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck		p.R1357*(1)|p.R1162*(1)		breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGAAAGAAATCGAGAGCATGG	0.473000													33	126					0	0	0.012213	0	0
BVES	11149	broad.mit.edu	37	6	105564691	105564691	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:105564691C>T	ENST00000314641.5	-	6	917	c.701G>A	c.(700-702)aGa>aAa	p.R234K	BVES_ENST00000336775.5_Missense_Mutation_p.R234K|BVES_ENST00000446408.2_Missense_Mutation_p.R234K	NM_001199563.1	NP_001186492.1	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance	234					epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity			NS(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|urinary_tract(1)	21		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				GTATGTTAATCTTTCTCTTGA	0.338000													5	29					0	0	0.001168	0	0
NEU3	10825	broad.mit.edu	37	11	74717525	74717525	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:74717525C>T	ENST00000294064.4	+	3	2301	c.1374C>T	c.(1372-1374)ttC>ttT	p.F458F	NEU3_ENST00000529024.1_Intron|NEU3_ENST00000532963.1_3'UTR|NEU3_ENST00000531509.1_Silent_p.F458F|NEU3_ENST00000544263.1_Silent_p.F425F|NEU3_ENST00000545272.1_Silent_p.F349F	NM_006656.5	NP_006647.3	A8K327	A8K327_HUMAN	sialidase 3 (membrane sialidase)	458										kidney(2)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	11						CAAGCCAATTCAAAAGCAATT	0.468000													20	83					0	0	0.014323	0	0
SIM1	6492	broad.mit.edu	37	6	100841510	100841510	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:100841510C>T	ENST00000369208.3	-	11	2205	c.1423G>A	c.(1423-1425)Ggc>Agc	p.G475S	SIM1_ENST00000262901.4_Missense_Mutation_p.G475S			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	475	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AAGTACCTGCCTGCCTCACAT	0.637000													13	74					0	0	0.003163	0	0
ESM1	11082	broad.mit.edu	37	5	54275181	54275181	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:54275181C>T	ENST00000381405.4	-	3	679	c.534G>A	c.(532-534)agG>agA	p.R178R	ESM1_ENST00000381403.4_Silent_p.R128R|ESM1_ENST00000598310.1_5'UTR	NM_007036.4	NP_008967.1	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1	178					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding			breast(1)|kidney(1)|large_intestine(4)|lung(4)	10		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			TTAACCATTTCCTCATTACGG	0.438000													14	120					0	0	0.006122	0	0
PLA2R1	22925	broad.mit.edu	37	2	160898553	160898553	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:160898553C>T	ENST00000283243.7	-	3	856	c.650G>A	c.(649-651)gGa>gAa	p.G217E	PLA2R1_ENST00000392771.1_Missense_Mutation_p.G217E	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	217	Fibronectin type-II.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						AGGGCAAAATCCCCACTTTTC	0.388000													17	71					0	0	0.010504	0	0
CDRT1	374286	broad.mit.edu	37	17	15516116	15516116	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:15516116C>T	ENST00000455584.2	-	11	1994	c.1951G>A	c.(1951-1953)Gat>Aat	p.D651N	CDRT1_ENST00000395906.3_Missense_Mutation_p.D341N																							TAATTAGGATCAATTCCTCTT	0.403000													13	82					0	0	0.013537	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808159	18808159	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:18808159G>A	ENST00000400664.1	+	1	736	c.684G>A	c.(682-684)gtG>gtA	p.V228V		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	228						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TCACCCGTGTGATAGGGGTCA	0.602000													16	58					0	0	0.004007	0	0
GABRQ	55879	broad.mit.edu	37	X	151821280	151821280	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:151821280C>T	ENST00000370306.2	+	9	1455	c.1435C>T	c.(1435-1437)Cct>Tct	p.P479S		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	479						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					CAGTATTTTTCCTACCGAAAT	0.542000													27	58					0	0	0.006320	0	0
WDR96	80217	broad.mit.edu	37	10	105893391	105893391	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:105893391C>T	ENST00000357060.3	-	35	4698	c.4583G>A	c.(4582-4584)aGa>aAa	p.R1528K	WDR96_ENST00000428666.1_Missense_Mutation_p.R1500K|WDR96_ENST00000479392.1_5'UTR	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1528										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TTGACGATCTCTTGAAAAAAA	0.328000													5	34					0	0	0.001168	0	0
DNAH9	1770	broad.mit.edu	37	17	11511499	11511499	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:11511499G>A	ENST00000262442.3	+	2	539	c.471G>A	c.(469-471)atG>atA	p.M157I	DNAH9_ENST00000579828.1_Missense_Mutation_p.M157I|DNAH9_ENST00000454412.2_Missense_Mutation_p.M157I|DNAH9_ENST00000579406.1_3'UTR	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	157	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGCCCCACATGATATGTGAGG	0.512000													29	137					0	0	0.008361	0	0
DENND1B	163486	broad.mit.edu	37	1	197552297	197552297	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:197552297G>A	ENST00000235453.4	-	15	1321	c.1044C>T	c.(1042-1044)ctC>ctT	p.L348L	DENND1B_ENST00000400967.2_Silent_p.L348L|DENND1B_ENST00000367396.3_Silent_p.L378L			Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B	378	dDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			NS(2)|breast(2)|kidney(2)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	22						TAAAAAGCTGGAGGTTAATGG	0.383000													17	70					0	0	0.008871	0	0
IGHV2-70	28454	broad.mit.edu	37	14	107179260	107179260	+	RNA	SNP	C	C	T	rs140988424	by1000genomes	TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:107179260C>T	ENST00000390634.2	-	0	78																											AAAGTATGTCCATGGTGGAGA	0.532000													4	31					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179591999	179591999	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:179591999C>T	ENST00000589042.1	-	69	20317	c.20093G>A	c.(20092-20094)aGa>aAa	p.R6698K	TTN_ENST00000342992.6_Missense_Mutation_p.R5454K|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.R6381K|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6381	Ig-like 48.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACACAACTCTGATTTCTGG	0.418000													5	26					0	0	0.000602	0	0
ALDOB	229	broad.mit.edu	37	9	104190787	104190787	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:104190787G>A	ENST00000374855.4	-	4	467	c.343C>T	c.(343-345)Cct>Tct	p.P115S	ALDOB_ENST00000468981.2_Intron	NM_000035.3	NP_000026.2	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	115					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(5)|prostate(2)|skin(4)|urinary_tract(1)	24		Acute lymphoblastic leukemia(62;0.0559)				CCTGCAAGAGGAGCACCTCCT	0.403000													23	80					0	0	0.003330	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64756156	64756156	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:64756156T>C	ENST00000536360.1	-	4	1285	c.472A>G	c.(472-474)Att>Gtt	p.I158V				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	158					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TCTGTAGCAATAACACCATGC	0.299000													13	68					0	0	0.013537	0	0
PKDCC	91461	broad.mit.edu	37	2	42280438	42280438	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:42280438G>A	ENST00000294964.5	+	2	879	c.699G>A	c.(697-699)acG>acA	p.T233T		NM_138370.2	NP_612379.2	Q504Y2	PKDCC_HUMAN	protein kinase domain containing, cytoplasmic	233	Protein kinase.				cell differentiation|embryonic digestive tract development|lung alveolus development|negative regulation of Golgi to plasma membrane protein transport|ossification|palate development|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|protein transport	Golgi apparatus	ATP binding|protein kinase activity			breast(2)|kidney(1)|lung(5)	8						CCACCATCACGGAGCTGGGCG	0.612000													16	114					0	0	0.004990	0	0
TPRA1	131601	broad.mit.edu	37	3	127292431	127292431	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:127292431G>A	ENST00000355552.3	-	11	1431	c.1055C>T	c.(1054-1056)tCc>tTc	p.S352F	TPRA1_ENST00000489960.1_Missense_Mutation_p.S352F|TPRA1_ENST00000450633.2_Missense_Mutation_p.S352F|TPRA1_ENST00000296210.7_3'UTR	NM_001136053.1	NP_001129525.1	Q86W33	TPRA1_HUMAN	transmembrane protein, adipocyte asscociated 1	352					aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity			endometrium(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	9						GCAGGGCATGGAAGCGATGTC	0.662000													13	67					0	0	0.003163	0	0
LPCAT1	79888	broad.mit.edu	37	5	1494858	1494858	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:1494858G>A	ENST00000283415.3	-	3	582	c.450C>T	c.(448-450)tcC>tcT	p.S150S		NM_024830.3	NP_079106.3	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	150					phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		TCATCACGATGGAGGACATCG	0.632000													13	63					0	0	0.002450	0	0
GALNT8	26290	broad.mit.edu	37	12	4829912	4829912	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:4829912C>T	ENST00000252318.2	+	1	406	c.69C>T	c.(67-69)ctC>ctT	p.L23L	RP11-234B24.6_ENST00000544741.2_Intron	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	23						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CTGTCAATCTCCTTCTGGTAT	0.507000													19	72					0	0	0.010504	0	0
NRXN1	9378	broad.mit.edu	37	2	51254734	51254734	+	Silent	SNP	C	C	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:51254734C>G	ENST00000404971.1	-	2	2017	c.678G>C	c.(676-678)ggG>ggC	p.G226G	NRXN1_ENST00000406859.3_Silent_p.G226G|NRXN1_ENST00000405472.3_Silent_p.G226G|NRXN1_ENST00000405581.1_Silent_p.G226G|NRXN1_ENST00000406316.2_Silent_p.G226G|NRXN1_ENST00000402717.3_Silent_p.G226G|NRXN1_ENST00000401669.2_Silent_p.G226G	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	226	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TGAGGCACACCCCGCCCTCGC	0.706000													9	17					0	0	0.004482	0	0
CR2	1380	broad.mit.edu	37	1	207641898	207641898	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:207641898C>T	ENST00000367057.3	+	3	661	c.472C>T	c.(472-474)Cct>Tct	p.P158S	CR2_ENST00000367059.3_Missense_Mutation_p.P158S|CR2_ENST00000367058.3_Missense_Mutation_p.P158S|CR2_ENST00000458541.2_Missense_Mutation_p.P158S|CR2_ENST00000485707.1_3'UTR	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	158	Sushi 3.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TCCAGCACTTCCTATGATCCA	0.453000													5	50					0	0	0.000602	0	0
CUX1	1523	broad.mit.edu	37	7	101747641	101747641	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:101747641G>A	ENST00000360264.3	+	6	485	c.465G>A	c.(463-465)gaG>gaA	p.E155E	CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000546411.2_Silent_p.E144E|CUX1_ENST00000393824.3_Silent_p.E118E|CUX1_ENST00000292538.4_Silent_p.E155E|CUX1_ENST00000292535.7_Silent_p.E144E|CUX1_ENST00000437600.4_Silent_p.E155E|CUX1_ENST00000556210.1_Silent_p.E144E|CUX1_ENST00000549414.2_Silent_p.E144E|CUX1_ENST00000547394.2_Silent_p.E139E|CUX1_ENST00000425244.2_Silent_p.E109E|CUX1_ENST00000550008.2_Silent_p.E144E	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	144					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						CACTTAAAGAGAAAATCCGAG	0.388000													18	110					0	0	0.006122	0	0
OTOF	9381	broad.mit.edu	37	2	26703111	26703111	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:26703111C>T	ENST00000272371.2	-	16	1998	c.1872G>A	c.(1870-1872)cgG>cgA	p.R624R	OTOF_ENST00000403946.3_Silent_p.R624R	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	624					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCCGTTTCTCCGGTCGATCA	0.582000													13	82					0	0	0.003163	0	0
NAALAD2	10003	broad.mit.edu	37	11	89909215	89909215	+	Silent	SNP	T	T	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:89909215T>G	ENST00000534061.1	+	15	1808	c.1578T>G	c.(1576-1578)cgT>cgG	p.R526R	NAALAD2_ENST00000375944.3_Intron|NAALAD2_ENST00000321955.4_Silent_p.R493R	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	526	NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GCAGAGCCCGTTACACTAAGA	0.388000													7	41					0	0	0.004482	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762216	130762216	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:130762216C>T	ENST00000392429.1	+	2	3027	c.649C>T	c.(649-651)Cgg>Tgg	p.R217W	TMEM200A_ENST00000545622.1_Missense_Mutation_p.R217W|TMEM200A_ENST00000296978.3_Missense_Mutation_p.R217W	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	217						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CTCGGGTTTTCGGAGCAGTTT	0.478000													8	24					0	0	0.003080	0	0
SNHG14	104472715	broad.mit.edu	37	15	25427746	25427746	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr15:25427746C>T	ENST00000424208.1	+	0	272					NR_003305.1																						TGCGCTCCTCCTTGAGGCAGC	0.622000													3	16					0	0	0.004672	0	0
MAN1A2	10905	broad.mit.edu	37	1	117984892	117984892	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:117984892C>T	ENST00000356554.3	+	6	1630	c.895C>T	c.(895-897)Ctt>Ttt	p.L299F		NM_006699.3	NP_006690.1	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	299					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	27	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		TGAGAAACTCCTTCCTGCCTT	0.343000													8	65					0	0	0.006214	0	0
USP6NL	9712	broad.mit.edu	37	10	11504989	11504989	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:11504989G>A	ENST00000379237.1	-	15	2332	c.1938C>T	c.(1936-1938)ttC>ttT	p.F646F	USP6NL_ENST00000277575.5_Silent_p.F663F	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	646						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						TGGCAGTAGGGAAGTGTTTGG	0.547000													3	26					0	0	0.004672	0	0
CYP4A11	1579	broad.mit.edu	37	1	47402994	47402994	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:47402994C>T	ENST00000310638.4	-	3	393	c.362G>A	c.(361-363)aGa>aAa	p.R121K	CYP4A11_ENST00000457840.2_Missense_Mutation_p.R17K|CYP4A11_ENST00000371905.1_Missense_Mutation_p.R121K|CYP4A11_ENST00000371904.4_Missense_Mutation_p.R121K|CYP4A11_ENST00000475477.1_5'UTR	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	121					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	AGCCAGGAATCTGTAGGAACC	0.448000													6	44					0	0	0.004482	0	0
MYO18B	84700	broad.mit.edu	37	22	26224751	26224751	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:26224751C>T	ENST00000335473.7	+	15	3045	c.2795C>T	c.(2794-2796)tCc>tTc	p.S932F	MYO18B_ENST00000536101.1_Missense_Mutation_p.S932F|MYO18B_ENST00000407587.2_Missense_Mutation_p.S932F	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	932	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AGATCCTTTTCCTCCCACCAT	0.567000													11	58					0	0	0.001855	0	0
TRAV23DV6	28660	broad.mit.edu	37	14	22555063	22555063	+	RNA	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr14:22555063G>A	ENST00000390451.2	+	0	234																											ACTTTCCATGGTACCAACAAT	0.398000													3	15					0	0	0.004672	0	0
SLC6A16	28968	broad.mit.edu	37	19	49813343	49813343	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:49813343G>A	ENST00000454748.3	-	4	855	c.654C>T	c.(652-654)ccC>ccT	p.P218P	SLC6A16_ENST00000335875.4_Silent_p.P218P			Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	218						integral to membrane|intracellular	neurotransmitter:sodium symporter activity			NS(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		CCCATGGAACGGGAAACTGGA	0.478000													14	77					0	0	0.004990	0	0
HOMER1	9456	broad.mit.edu	37	5	78672020	78672020	+	Splice_Site	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:78672020C>T	ENST00000334082.6	-	9	2319	c.876_splice	c.e9-1	p.E293_splice	HOMER1_ENST00000535690.1_Splice_Site_p.E119_splice|HOMER1_ENST00000282260.6_Splice_Site_p.E163_splice|HOMER1_ENST00000508576.1_Splice_Site_p.R176_splice	NM_004272.3	NP_004263.1	Q86YM7	HOME1_HUMAN	homer homolog 1 (Drosophila)	293					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|skin(1)	14		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		ATTTCTACTTCCTTCAGAAAC	0.363000													10	43					0	0	0.006214	0	0
PTPRB	5787	broad.mit.edu	37	12	70960386	70960386	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:70960386C>T	ENST00000334414.6	-	15	3777	c.3733G>A	c.(3733-3735)Gat>Aat	p.D1245N	PTPRB_ENST00000550857.1_Missense_Mutation_p.D937N|PTPRB_ENST00000550358.1_Missense_Mutation_p.D1157N|PTPRB_ENST00000551525.1_Missense_Mutation_p.D1244N|PTPRB_ENST00000538708.1_Intron|PTPRB_ENST00000451516.2_Missense_Mutation_p.D937N|PTPRB_ENST00000261266.5_Missense_Mutation_p.D1027N	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1027	Fibronectin type-III 14.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGCAGGATATCATATCTTTCT	0.423000													19	70					0	0	0.007413	0	0
GPATCH2	55105	broad.mit.edu	37	1	217793136	217793136	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:217793136G>A	ENST00000366935.3	-	2	872	c.762C>T	c.(760-762)ctC>ctT	p.L254L	GPATCH2_ENST00000366934.3_Silent_p.L254L	NM_018040.2	NP_060510.1	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	254						intracellular	nucleic acid binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)	35				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		TTTCACTCATGAGCTCATCTG	0.294000													4	34					0	0	0.009096	0	0
CEP72	55722	broad.mit.edu	37	5	640714	640714	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:640714G>A	ENST00000264935.5	+	9	1624	c.1534G>A	c.(1534-1536)Gag>Aag	p.E512K	CEP72_ENST00000444221.1_3'UTR	NM_018140.3	NP_060610.2	Q9P209	CEP72_HUMAN	centrosomal protein 72kDa	512					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(5)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	20			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			CACACACAAGGAGCTGGTGAG	0.622000													4	33					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179464536	179464536	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:179464536C>T	ENST00000589042.1	-	289	56316	c.56092G>A	c.(56092-56094)Gaa>Aaa	p.E18698K	TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E16130K|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E9825K|TTN_ENST00000460472.2_Missense_Mutation_p.E9633K|TTN_ENST00000591111.1_Missense_Mutation_p.E17057K|TTN_ENST00000359218.5_Missense_Mutation_p.E9758K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17057	Fibronectin type-III 35.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGTTCCTTCTTCAACCTCC	0.383000													10	39					0	0	0.010729	0	0
TAAR6	319100	broad.mit.edu	37	6	132892276	132892276	+	Silent	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr6:132892276A>G	ENST00000275198.1	+	1	816	c.816A>G	c.(814-816)ttA>ttG	p.L272L		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	272						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TTTCATGGTTACCATATAGCA	0.413000													17	57					0	0	0.004007	0	0
AKAP1	8165	broad.mit.edu	37	17	55193564	55193564	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:55193564C>T	ENST00000337714.3	+	7	2607	c.2374C>T	c.(2374-2376)Cga>Tga	p.R792*	AKAP1_ENST00000572557.1_Nonsense_Mutation_p.R792*|AKAP1_ENST00000539273.1_Nonsense_Mutation_p.R792*|AKAP1_ENST00000571629.1_Nonsense_Mutation_p.R792*	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	792	Tudor.				blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					AGTGGAGATTCGATACGTGGA	0.607000													4	69					0	0	0.001168	0	0
ABCC11	85320	broad.mit.edu	37	16	48248827	48248827	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr16:48248827G>A	ENST00000394747.1	-	8	1562	c.1213C>T	c.(1213-1215)Cac>Tac	p.H405Y	ABCC11_ENST00000394748.1_Missense_Mutation_p.H405Y|ABCC11_ENST00000537808.1_Missense_Mutation_p.H405Y|ABCC11_ENST00000353782.5_Missense_Mutation_p.H405Y|ABCC11_ENST00000356608.2_Missense_Mutation_p.H405Y	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	405	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				AAGGATGTGTGGATGAGAACC	0.483000													8	36					0	0	0.004482	0	0
UNC5A	90249	broad.mit.edu	37	5	176295819	176295819	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:176295819C>T	ENST00000329542.4	+	5	849	c.575C>T	c.(574-576)cCg>cTg	p.P192L	UNC5A_ENST00000261961.3_Missense_Mutation_p.P152L	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	192	Ig-like C2-type.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGTGGACCCGTCCCTGGAC	0.662000													21	53					0	0	0.002780	0	0
CDH9	1007	broad.mit.edu	37	5	26881640	26881640	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:26881640A>G	ENST00000231021.4	-	12	2147	c.1975T>C	c.(1975-1977)Tac>Cac	p.Y659H		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	659					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TCATCGTTGTAGGTCACAATG	0.423000													19	130					0	0	0.010504	0	0
C1orf87	127795	broad.mit.edu	37	1	60505758	60505758	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:60505758T>C	ENST00000371201.3	-	5	685	c.578A>G	c.(577-579)aAc>aGc	p.N193S	C1orf87_ENST00000450089.2_Intron	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	193							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						TTCTAATAAGTTGGAACTCAA	0.448000													17	65					0	0	0.004990	0	0
DNAH5	1767	broad.mit.edu	37	5	13931219	13931219	+	Splice_Site	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:13931219C>T	ENST00000265104.4	-	2	296	c.192_splice	c.e2+1	p.Q64_splice		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	64	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CGCATCCCACCTGATTCCCTT	0.502000									Kartagener syndrome				5	54					0	0	0.001984	0	0
FAM71A	149647	broad.mit.edu	37	1	212798721	212798721	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:212798721G>A	ENST00000294829.3	+	1	933	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	168										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		TGCCTATTGGGAAAAACTAAT	0.498000													34	144					0	0	0.003755	0	0
ZNF341	84905	broad.mit.edu	37	20	32357965	32357965	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:32357965C>T	ENST00000375200.1	+	10	1854	c.1489C>T	c.(1489-1491)Cac>Tac	p.H497Y	ZNF341_ENST00000342427.2_Missense_Mutation_p.H490Y			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	497					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						CATCAAGAGCCACCAGGAGGA	0.597000													13	31					0	0	0.002450	0	0
ZNF530	348327	broad.mit.edu	37	19	58118641	58118641	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:58118641C>T	ENST00000332854.6	+	3	1968	c.1748C>T	c.(1747-1749)tCc>tTc	p.S583F	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGTGGAAAATCCTTTAGCCAA	0.378000													10	22					0	0	0.008291	0	0
ANKS1B	56899	broad.mit.edu	37	12	99201651	99201651	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr12:99201651G>A	ENST00000550693.2	-	5	860	c.607C>T	c.(607-609)Cct>Tct	p.P203S	ANKS1B_ENST00000546568.1_Intron|ANKS1B_ENST00000547446.1_Intron|ANKS1B_ENST00000329257.7_Intron|ANKS1B_ENST00000341752.7_Intron|ANKS1B_ENST00000332712.7_Missense_Mutation_p.P203S|ANKS1B_ENST00000333732.7_Missense_Mutation_p.P43S|ANKS1B_ENST00000546960.1_Intron|ANKS1B_ENST00000547776.2_Intron|ANKS1B_ENST00000547010.1_Intron|ANKS1B_ENST00000549025.2_Missense_Mutation_p.P111S|ANKS1B_ENST00000549493.2_Missense_Mutation_p.P263S|ANKS1B_ENST00000549558.2_Intron	NM_001204069.1|NM_001204070.1	NP_001190998.1|NP_001190999.1	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	991						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GCTGAGAAAGGAAATCCTGCG	0.388000													3	17					0	0	0.001168	0	0
IGKV1D-12	28903	broad.mit.edu	37	2	90199105	90199105	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:90199105C>T	ENST00000390276.2	+	0	447																											GGCAGTGGATCTGGGACAGAT	0.502000													22	117					0	0	0.005443	0	0
RP11-337C18.8	0	broad.mit.edu	37	1	146650562	146650562	+	RNA	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:146650562C>T	ENST00000607149.1	+	0	350																											CAAAGAAATTCCTGGATGCTG	0.433000													6	19					0	0	0.001984	0	0
PRKCQ	5588	broad.mit.edu	37	10	6553016	6553016	+	Translation_Start_Site	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:6553016C>T	ENST00000539722.1	-	0	296				PRKCQ_ENST00000397176.2_Missense_Mutation_p.V87M|PRKCQ_ENST00000263125.5_Missense_Mutation_p.V87M			Q04759	KPCT_HUMAN	protein kinase C, theta						axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						TAGAGCTCCACGGTGGTTTCA	0.483000													16	95					0	0	0.004007	0	0
LRRTM2	26045	broad.mit.edu	37	5	138208982	138208982	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:138208982A>T	ENST00000274711.6	-	2	1646	c.1268T>A	c.(1267-1269)gTa>gAa	p.V423E	LRRTM2_ENST00000518785.1_3'UTR|CTNNA1_ENST00000518825.1_Intron|CTNNA1_ENST00000355078.5_Intron|CTNNA1_ENST00000302763.7_Intron|LRRTM2_ENST00000521094.2_Intron|CTNNA1_ENST00000520400.1_Intron	NM_015564.2	NP_056379.1	O43300	LRRT2_HUMAN	leucine rich repeat transmembrane neuronal 2	423						cell junction|integral to membrane|postsynaptic membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(1)|urinary_tract(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TCCCGTAATTACCCGCTGAGT	0.413000													24	100					0	0	0.005443	0	0
MXRA5	25878	broad.mit.edu	37	X	3241355	3241355	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chrX:3241355G>A	ENST00000217939.6	-	5	2525	c.2371C>T	c.(2371-2373)Cgt>Tgt	p.R791C		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	791						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TTTTTCCCACGGACTTTGGCT	0.453000													17	37					0	0	0.004990	0	0
DNAH17	8632	broad.mit.edu	37	17	76525692	76525692	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr17:76525692C>T	ENST00000389840.5	-	22	3493	c.3369G>A	c.(3367-3369)gtG>gtA	p.V1123V	DNAH17_ENST00000585328.1_Silent_p.V1120V					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCATCACCTCCACAAGCCCAT	0.562000													17	84					0	0	0.004990	0	0
MUC16	94025	broad.mit.edu	37	19	9070856	9070856	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:9070856G>A	ENST00000397910.4	-	3	16793	c.16590C>T	c.(16588-16590)tcC>tcT	p.S5530S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5532	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTCTGAGATGGATGTTCTGC	0.483000													18	79					0	0	0.007413	0	0
NGEF	25791	broad.mit.edu	37	2	233756070	233756070	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr2:233756070G>A	ENST00000264051.3	-	8	1548	c.1270C>T	c.(1270-1272)Cag>Tag	p.Q424*	NGEF_ENST00000373552.4_Nonsense_Mutation_p.Q332*|NGEF_ENST00000539537.1_Nonsense_Mutation_p.Q147*	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	424	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GGCTGTACCTGGACCAACAGC	0.602000													20	79					0	0	0.014323	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214382	140214382	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr5:140214382G>A	ENST00000525929.1	+	1	414	c.414G>A	c.(412-414)agG>agA	p.R138R	PCDHA5_ENST00000529619.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000378125.3_Silent_p.R138R	NM_018910.2	NP_061733.1												p.R138S(2)		NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACACAAAGGAATCTGTTCA	0.567000													24	58					0	0	0.003330	0	0
ANKRD54	129138	broad.mit.edu	37	22	38240228	38240228	+	Silent	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr22:38240228C>T	ENST00000215941.4	-	1	210	c.18G>A	c.(16-18)ggG>ggA	p.G6G	ANKRD54_ENST00000411961.2_Silent_p.G6G	NM_138797.2	NP_620152.1	Q6NXT1	ANR54_HUMAN	ankyrin repeat domain 54	6										lung(1)	1	Melanoma(58;0.045)					CGTCCGCGTCCCCGGCGGCGG	0.736000													3	14					0	0	0.004672	0	0
SLC35B4	84912	broad.mit.edu	37	7	133986839	133986839	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:133986839G>A	ENST00000378509.4	-	5	667	c.368C>T	c.(367-369)tCc>tTc	p.S123F		NM_032826.4	NP_116215.1	Q969S0	S35B4_HUMAN	solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4	123						Golgi membrane|integral to membrane	UDP-N-acetylglucosamine transmembrane transporter activity|UDP-xylose transmembrane transporter activity			large_intestine(1)|lung(2)|skin(1)|stomach(1)	5						CAGGGCAATGGAGGTATATTT	0.343000													18	92					0	0	0.007413	0	0
TYK2	7297	broad.mit.edu	37	19	10464889	10464889	+	Silent	SNP	A	A	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:10464889A>G	ENST00000525621.1	-	20	3218	c.2737T>C	c.(2737-2739)Ttg>Ctg	p.L913L	TYK2_ENST00000264818.6_Silent_p.L913L|TYK2_ENST00000524462.1_Silent_p.L728L	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	913	Protein kinase 2.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			TAGCAGTACAAGCTGACCTTG	0.657000													24	68					0	0	0.003330	0	0
WDFY3	23001	broad.mit.edu	37	4	85752612	85752612	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:85752612G>A	ENST00000322366.6	-	8	1130	c.723C>T	c.(721-723)acC>acT	p.T241T	WDFY3_ENST00000295888.4_Silent_p.T241T			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	241						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GACGAGATATGGTCATGAGGA	0.388000													19	83					0	0	0.012319	0	0
C19orf24	55009	broad.mit.edu	37	19	1278918	1278918	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr19:1278918G>A	ENST00000469144.1	+	3	418	c.109G>A	c.(109-111)Gag>Aag	p.E37K	C19orf24_ENST00000409293.4_3'UTR			Q9BVV8	CS024_HUMAN	chromosome 19 open reading frame 24	11						cytoplasm|extracellular region part|integral to membrane							Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000332)|all_lung(49;0.000498)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAACCCGAGAGCTCCTTTT	0.687000													28	82					0	0	0.008361	0	0
PCLO	27445	broad.mit.edu	37	7	82545710	82545710	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr7:82545710G>A	ENST00000423517.2	-	7	11929	c.11592C>T	c.(11590-11592)ttC>ttT	p.F3864F	PCLO_ENST00000437081.1_Silent_p.F584F|PCLO_ENST00000333891.8_Silent_p.F3864F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3795	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TAAACTGGCTGAATTCAGTTT	0.468000													121	271					0	0	0.014410	0	0
UGT2A2	574537	broad.mit.edu	37	4	70504997	70504997	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr4:70504997C>T	ENST00000457664.2	-	1	361	c.362G>A	c.(361-363)gGa>gAa	p.G121E	UGT2A1_ENST00000286604.4_Intron|UGT2A1_ENST00000512704.1_Intron|UGT2A1_ENST00000514019.1_Missense_Mutation_p.G322E|UGT2A1_ENST00000503640.1_Intron	NM_001105677.2	NP_001099147.2																					TAGAAGTTTTCCTAGTTCTTT	0.363000													18	63					0	0	0.006122	0	0
TENM4	26011	broad.mit.edu	37	11	78440604	78440604	+	Silent	SNP	G	G	A			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr11:78440604G>A	ENST00000278550.7	-	22	3685	c.3223C>T	c.(3223-3225)Ctg>Ttg	p.L1075L		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		CTGATCCTCAGGACAGATTTG	0.577000													9	53					0	0	0.006214	0	0
DDX11L1	100287102	broad.mit.edu	37	1	13290	13291	+	RNA	DEL	CT	CT	-			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr1:13290_13291delCT	ENST00000456328.2	+	0	538_539					NR_046018.2|NR_051986.1																						ACCCGGCACCCTGTCCTGGACA	0.569													3	6	---	---	---	---					
MST1	4485	broad.mit.edu	37	3	49723322	49723327	+	In_Frame_Del	DEL	GCGCTG	GCGCTG	-			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr3:49723322_49723327delGCGCTG	ENST00000449682.2	-	10	1577_1582	c.1216_1221delCAGCGC	c.(1216-1221)del	p.QR406del	MST1_ENST00000383728.3_3'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	392	Kringle 4.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CAGCGGACCAGCGCTGGCACTGGACA	0.704													8	194	---	---	---	---					
ADCK5	203054	broad.mit.edu	37	8	145617535	145617549	+	Splice_Site	DEL	GGGGGTGCAAGGTGA	GGGGGTGCAAGGTGA	-	rs11270020		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr8:145617535_145617549delGGGGGTGCAAGGTGA	ENST00000308860.6	+	12	1301_1311	c.1267_splice	c.e12+1	p.L419_splice		NM_174922.3	NP_777582.3	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	419	Protein kinase.					integral to membrane	protein serine/threonine kinase activity	p.?(2)		endometrium(1)|lung(2)|prostate(2)|skin(1)|stomach(2)	8	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CAGCCGCACTGGGGGTGCAAGGTGAGGGGGTGCAA	0.730													3	5	---	---	---	---					
LOC440173	440173	broad.mit.edu	37	9	89628125	89628125	+	RNA	DEL	A	A	-			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr9:89628125delA	ENST00000602579.1	-	0	256					NR_027471.1																						GTCTCCCTTCAAAAAAAAAAA	0.363													3	5	---	---	---	---					
PRLHR	2834	broad.mit.edu	37	10	120353838	120353839	+	Frame_Shift_Ins	INS	-	-	G			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr10:120353838_120353839insG	ENST00000239032.2	-	2	1056_1057	c.918_919insC	c.(916-921)caccatfs	p.H307fs	PRLHR_ENST00000369169.1_Frame_Shift_Ins_p.H307fs	NM_004248.2	NP_004239.1	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	307					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity	p.A307P(1)|p.H306H(1)		large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GGGTCGATGGCGTGGGGGTCGA	0.649													14	67	---	---	---	---					
CTCFL	140690	broad.mit.edu	37	20	56099187	56099187	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr20:56099187delT	ENST00000426658.2	-	1	736	c.75delA	c.(73-75)aafs	p.K25fs	CTCFL_ENST00000243914.3_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000433949.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000422109.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000432255.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000429804.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000423479.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000371196.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000422869.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000539382.1_Intron|CTCFL_ENST00000502686.2_Intron			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	25					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CCTTCAGGCCTTTTTCCGGCA	0.502													7	575	---	---	---	---					
MIR3648-1	100500862	broad.mit.edu	37	21	9825838	9825839	+	RNA	INS	-	-	GCG	rs3052281		TCGA-GN-A269-01A-11D-A19A-08	TCGA-GN-A269-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8e00a4-a509-48ef-bc77-34845b51bb9d	b21836b0-f16e-4eec-a83c-fb42f836194a	g.chr21:9825838_9825839insGCG	ENST00000581792.1	+	0	7_8					NR_037421.1																						cggccgcgactgcggcggcggt	0.842													5	8	---	---	---	---					
