#version 2.4
## 
## Oncotator v1.8.0.0 | Flat File Reference hg19 | GENCODE v19 EFFECT | UniProt_AAxform 2014_12 | ClinVar 12.03.20 | ESP 6500SI-V2 | ORegAnno UCSC Track | dbSNP build 142 | CCLE_By_GP 09292010 | COSMIC v62_291112 | 1000gp3 20130502 | UniProt_AA 2014_12 | dbNSFP v2.4 | ESP 6500SI-V2 | COSMIC_FusionGenes v62_291112 | gencode_xref_refseq metadata_v19 | CCLE_By_Gene 09292010 | ACHILLES_Lineage_Results 110303 | CGC full_2012-03-15 | UniProt 2014_12 | HumanDNARepairGenes 20110905 | HGNC Sept172014 | COSMIC_Tissue 291112 | Familial_Cancer_Genes 20110905 | TUMORScape 20100104 | Ensembl ICGC MUCOPA | TCGAScape 110405 | MutSig Published Results 20110905 
Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	i_1000gp3_AA	i_1000gp3_AC	i_1000gp3_AF	i_1000gp3_AFR_AF	i_1000gp3_AMR_AF	i_1000gp3_AN	i_1000gp3_CIEND	i_1000gp3_CIPOS	i_1000gp3_CS	i_1000gp3_DP	i_1000gp3_EAS_AF	i_1000gp3_END	i_1000gp3_EUR_AF	i_1000gp3_IMPRECISE	i_1000gp3_MC	i_1000gp3_MEINFO	i_1000gp3_MEND	i_1000gp3_MLEN	i_1000gp3_MSTART	i_1000gp3_NS	i_1000gp3_SAS_AF	i_1000gp3_SVLEN	i_1000gp3_SVTYPE	i_1000gp3_TSD	i_ACHILLES_Lineage_Results_Top_Genes	i_Annotation_Transcript	i_CCLE_ONCOMAP_overlapping_mutations	i_CCLE_ONCOMAP_total_mutations_in_gene	i_CGC_Cancer Germline Mut	i_CGC_Cancer Molecular Genetics	i_CGC_Cancer Somatic Mut	i_CGC_Cancer Syndrome	i_CGC_Chr	i_CGC_Chr Band	i_CGC_GeneID	i_CGC_Mutation_Type	i_CGC_Name	i_CGC_Other Germline Mut	i_CGC_Other_Diseases	i_CGC_Tissue Type	i_CGC_Translocation_Partner	i_CGC_Tumor_Types_Germline	i_CGC_Tumor_Types_Somatic	i_COSMIC_fusion_genes	i_COSMIC_n_overlapping_mutations	i_COSMIC_overlapping_mutation_descriptions	i_COSMIC_overlapping_mutations	i_COSMIC_overlapping_primary_sites	i_COSMIC_tissue_types_affected	i_COSMIC_total_alterations_in_gene	i_ClinVar_ASSEMBLY	i_ClinVar_HGMD_ID	i_ClinVar_SYM	i_ClinVar_TYPE	i_ClinVar_rs	i_Codon_Change	i_DNARepairGenes_Role	i_Description	i_DrugBank	i_ESP_AA	i_ESP_AAC	i_ESP_AA_AC	i_ESP_AA_AGE	i_ESP_AA_GTC	i_ESP_AvgAAsampleReadDepth	i_ESP_AvgEAsampleReadDepth	i_ESP_AvgSampleReadDepth	i_ESP_CA	i_ESP_CDP	i_ESP_CG	i_ESP_CP	i_ESP_Chromosome	i_ESP_DBSNP	i_ESP_DP	i_ESP_EA_AC	i_ESP_EA_AGE	i_ESP_EA_GTC	i_ESP_EXOME_CHIP	i_ESP_FG	i_ESP_GL	i_ESP_GM	i_ESP_GS	i_ESP_GTC	i_ESP_GTS	i_ESP_GWAS_PUBMED	i_ESP_MAF	i_ESP_PH	i_ESP_PP	i_ESP_Position	i_ESP_TAC	i_ESP_TotalAAsamplesCovered	i_ESP_TotalEAsamplesCovered	i_ESP_TotalSamplesCovered	i_Ensembl_so_accession	i_Ensembl_so_term	i_Entrez_Gene_Id	i_FamilialCancerDatabase_Syndromes	i_Familial_Cancer_Genes_Reference	i_Familial_Cancer_Genes_Synonym	i_GO_Biological_Process	i_GO_Cellular_Component	i_GO_Molecular_Function	i_Genome_Change	i_HGNC_Accession Numbers	i_HGNC_CCDS IDs	i_HGNC_Chromosome	i_HGNC_Date Modified	i_HGNC_Date Name Changed	i_HGNC_Date Symbol Changed	i_HGNC_Ensembl Gene ID	i_HGNC_Ensembl ID(supplied by Ensembl)	i_HGNC_Enzyme IDs	i_HGNC_Gene family description	i_HGNC_HGNC ID	i_HGNC_Locus Group	i_HGNC_Locus Type	i_HGNC_Name Synonyms	i_HGNC_OMIM ID(supplied by NCBI)	i_HGNC_Previous Names	i_HGNC_Previous Symbols	i_HGNC_Primary IDs	i_HGNC_Pubmed IDs	i_HGNC_Record Type	i_HGNC_RefSeq(supplied by NCBI)	i_HGNC_Secondary IDs	i_HGNC_Status	i_HGNC_Synonyms	i_HGNC_UCSC ID(supplied by UCSC)	i_HGNC_UniProt ID(supplied by UniProt)	i_HGNC_VEGA IDs	i_HGVS_coding_DNA_change	i_HGVS_genomic_change	i_HGVS_protein_change	i_MUTSIG_Published_Results	i_OREGANNO_ID	i_OREGANNO_Values	i_ORegAnno_bin	i_Other_Transcripts	i_Protein_Change	i_Refseq_mRNA_Id	i_Refseq_prot_Id	i_SwissProt_acc_Id	i_SwissProt_entry_Id	i_TCGAscape_Amplification_Peaks	i_TCGAscape_Deletion_Peaks	i_Transcript_Exon	i_Transcript_Position	i_Transcript_Strand	i_Tumorscape_Amplification_Peaks	i_Tumorscape_Deletion_Peaks	i_UniProt_AApos	i_UniProt_Experimental_Info	i_UniProt_Natural_Variations	i_UniProt_Region	i_UniProt_Site	i_UniProt_alt_uniprot_accessions	i_Variant_Classification	i_Variant_Type	i_annotation_transcript	i_build	i_cDNA_Change	i_ccds_id	i_dbNSFP_1000Gp1_AC	i_dbNSFP_1000Gp1_AF	i_dbNSFP_1000Gp1_AFR_AC	i_dbNSFP_1000Gp1_AFR_AF	i_dbNSFP_1000Gp1_AMR_AC	i_dbNSFP_1000Gp1_AMR_AF	i_dbNSFP_1000Gp1_ASN_AC	i_dbNSFP_1000Gp1_ASN_AF	i_dbNSFP_1000Gp1_EUR_AC	i_dbNSFP_1000Gp1_EUR_AF	i_dbNSFP_Ancestral_allele	i_dbNSFP_CADD_phred	i_dbNSFP_CADD_raw	i_dbNSFP_CADD_raw_rankscore	i_dbNSFP_ESP6500_AA_AF	i_dbNSFP_ESP6500_EA_AF	i_dbNSFP_Ensembl_geneid	i_dbNSFP_Ensembl_transcriptid	i_dbNSFP_FATHMM_pred	i_dbNSFP_FATHMM_rankscore	i_dbNSFP_FATHMM_score	i_dbNSFP_GERP++_NR	i_dbNSFP_GERP++_RS	i_dbNSFP_GERP++_RS_rankscore	i_dbNSFP_Interpro_domain	i_dbNSFP_LRT_Omega	i_dbNSFP_LRT_converted_rankscore	i_dbNSFP_LRT_pred	i_dbNSFP_LRT_score	i_dbNSFP_LR_pred	i_dbNSFP_LR_rankscore	i_dbNSFP_LR_score	i_dbNSFP_MutationAssessor_pred	i_dbNSFP_MutationAssessor_rankscore	i_dbNSFP_MutationAssessor_score	i_dbNSFP_MutationTaster_converted_rankscore	i_dbNSFP_MutationTaster_pred	i_dbNSFP_MutationTaster_score	i_dbNSFP_Polyphen2_HDIV_pred	i_dbNSFP_Polyphen2_HDIV_rankscore	i_dbNSFP_Polyphen2_HDIV_score	i_dbNSFP_Polyphen2_HVAR_pred	i_dbNSFP_Polyphen2_HVAR_rankscore	i_dbNSFP_Polyphen2_HVAR_score	i_dbNSFP_RadialSVM_pred	i_dbNSFP_RadialSVM_rankscore	i_dbNSFP_RadialSVM_score	i_dbNSFP_Reliability_index	i_dbNSFP_SIFT_converted_rankscore	i_dbNSFP_SIFT_pred	i_dbNSFP_SIFT_score	i_dbNSFP_SLR_test_statistic	i_dbNSFP_SiPhy_29way_logOdds	i_dbNSFP_SiPhy_29way_logOdds_rankscore	i_dbNSFP_SiPhy_29way_pi	i_dbNSFP_UniSNP_ids	i_dbNSFP_Uniprot_aapos	i_dbNSFP_Uniprot_acc	i_dbNSFP_Uniprot_id	i_dbNSFP_aaalt	i_dbNSFP_aapos	i_dbNSFP_aapos_FATHMM	i_dbNSFP_aapos_SIFT	i_dbNSFP_aaref	i_dbNSFP_cds_strand	i_dbNSFP_codonpos	i_dbNSFP_fold-degenerate	i_dbNSFP_genename	i_dbNSFP_hg18_pos(1-coor)	i_dbNSFP_phastCons100way_vertebrate	i_dbNSFP_phastCons100way_vertebrate_rankscore	i_dbNSFP_phastCons46way_placental	i_dbNSFP_phastCons46way_placental_rankscore	i_dbNSFP_phastCons46way_primate	i_dbNSFP_phastCons46way_primate_rankscore	i_dbNSFP_phyloP100way_vertebrate	i_dbNSFP_phyloP100way_vertebrate_rankscore	i_dbNSFP_phyloP46way_placental	i_dbNSFP_phyloP46way_placental_rankscore	i_dbNSFP_phyloP46way_primate	i_dbNSFP_phyloP46way_primate_rankscore	i_dbNSFP_refcodon	i_entrez_gene_id	i_gc_content_full	i_gencode_transcript_name	i_gencode_transcript_status	i_gencode_transcript_tags	i_gencode_transcript_type	i_gene_type	i_havana_transcript	i_refseq_mrna_id	i_secondary_variant_classification	i_t_alt_count_full	i_t_ref_count_full	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample
ZXDA	7789	broad.mit.edu	37	X	57936620	57936620	+	Missense_Mutation	SNP	G	G	C	rs151072020		TCGA-DJ-A4UP-01A-11D-A257-08	TCGA-DJ-A4UP-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee4bf1b6-4123-4c18-987a-f814b572a708	eaf8980b-fe88-4642-ba40-8b94e462e275	g.chrX:57936620G>C	ENST00000358697.4	-	1	447	c.235C>G	c.(235-237)Cat>Gat	p.H79D		NM_007156.4	NP_009087.1	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	79					positive regulation of transcription, DNA-templated (GO:0045893)|transcription, DNA-templated (GO:0006351)	nucleus (GO:0005634)	C2H2 zinc finger domain binding (GO:0070742)|metal ion binding (GO:0046872)|nucleic acid binding (GO:0003676)|sequence-specific DNA binding transcription factor activity (GO:0003700)			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|prostate(2)|skin(1)	37						CTAGGTTGATGGGGCCTCGGC	0.756													G|||	9	0.00238411	0.0023	0.0043	3775	,	,		7164	0.001		0.0	False		,,,				2504	0.002					uc004dve.3																			0				breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|prostate(2)|skin(1)	37						c.(235-237)Cat>Gat		Homo sapiens zinc finger, X-linked, duplicated A (ZXDA), mRNA.		G	ASP/HIS	1,3605		0,1,1541,522	11.0	12.0	12.0		235	0.1	0.0	X	dbSNP_134	12	0,6443		0,0,2353,1737	yes	missense	ZXDA	NM_007156.4	81	0,1,3894,2259	CC,CG,GG,G		0.0,0.0277,0.01	benign	79/800	57936620	1,10048	2064	4090	6154	SO:0001583	missense	7789				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	g.chrX:57936620G>C	L14787	CCDS14376.1	Xp11.21	2013-01-08			ENSG00000198205	ENSG00000198205		"""Zinc fingers, C2H2-type"""	13198	protein-coding gene	gene with protein product	"""zinc finger protein 896"""	300235				8268913	Standard	NM_007156		Approved	ZNF896	uc004dve.3	P98168	OTTHUMG00000021688	ENST00000358697.4:c.235C>G	X.37:g.57936620G>C	ENSP00000351530:p.His79Asp						p.H79D	NM_007156	NP_009087	P98168	ZXDA_HUMAN			0	448	-			79					Q9UJP7	Missense_Mutation	SNP	ENST00000358697.4	37	c.235C>G	CCDS14376.1	3	0.0018083182640144665	0	0.0	0	0.0	0	0.0	2	0.002638522427440633	.	0.001	-3.048569	0.00039	2.77E-4	0.0	ENSG00000198205	ENST00000358697	T	0.18960	2.18	2.97	0.144	0.14824	.	0.883731	0.09514	N	0.791822	T	0.04407	0.0121	N	0.00707	-1.245	0.09310	N	1	B	0.02656	0.0	B	0.01281	0.0	T	0.38735	-0.9647	9	.	.	.	.	0.4688	0.00528	0.1995:0.3486:0.1943:0.2576	.	79	P98168	ZXDA_HUMAN	D	79	ENSP00000351530:H79D	.	H	-	1	0	ZXDA	57953345	0.000000	0.05858	0.001000	0.08648	0.051000	0.14879	0.024000	0.13555	-0.084000	0.12595	-0.777000	0.03380	CAT		0.756	ZXDA-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000056925.1	NM_007156		3	23	0	0	0	1	0	3	23				
ADAMDEC1	27299	broad.mit.edu	37	8	24250806	24250806	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A4UP-01A-11D-A257-08	TCGA-DJ-A4UP-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee4bf1b6-4123-4c18-987a-f814b572a708	eaf8980b-fe88-4642-ba40-8b94e462e275	g.chr8:24250806T>C	ENST00000256412.4	+	3	459	c.239T>C	c.(238-240)aTg>aCg	p.M80T	RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000538205.1_Start_Codon_SNP_p.M1T|RP11-624C23.1_ENST00000519689.1_RNA|ADAMDEC1_ENST00000522298.1_Start_Codon_SNP_p.M1T	NM_014479.3	NP_055294.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	80					immune response (GO:0006955)|negative regulation of cell adhesion (GO:0007162)	extracellular region (GO:0005576)	metalloendopeptidase activity (GO:0004222)|zinc ion binding (GO:0008270)			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CAATATCAGATGATCTTAAAT	0.303																																					Ovarian(147;687 1849 3699 25981 31337)	uc003xdz.2																			0				NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9						c.(238-240)aTg>aCg		Homo sapiens ADAM-like, decysin 1 (ADAMDEC1), transcript variant 1, mRNA.							64.0	68.0	67.0					8																	24250806		2203	4298	6501	SO:0001583	missense	27299				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding	g.chr8:24250806T>C	Y13323	CCDS6044.1, CCDS55212.1	8p12	2008-08-07			ENSG00000134028	ENSG00000134028			16299	protein-coding gene	gene with protein product		606393				9271581, 12037602	Standard	NM_001145271		Approved	M12.219	uc003xdz.2	O15204	OTTHUMG00000097858	ENST00000256412.4:c.239T>C	8.37:g.24250806T>C	ENSP00000256412:p.Met80Thr					ADAMDEC1_uc010lub.2_Missense_Mutation_p.M1T|ADAMDEC1_uc011lab.1_Missense_Mutation_p.M1T	p.M80T	NM_014479	NP_001138744	O15204	ADEC1_HUMAN		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)	2	459	+		Prostate(55;0.0181)	80					B7ZAK5	Missense_Mutation	SNP	ENST00000256412.4	37	c.239T>C	CCDS6044.1	.	.	.	.	.	.	.	.	.	.	T	10.46	1.357774	0.24598	.	.	ENSG00000134028	ENST00000256412;ENST00000538205;ENST00000522298	T;T;T	0.06068	3.35;4.2;4.2	5.47	5.47	0.80525	Peptidase M12B, propeptide (1);	0.394455	0.24504	N	0.037952	T	0.10766	0.0263	M	0.62723	1.935	0.80722	D	1	B	0.30406	0.278	B	0.34385	0.181	T	0.02059	-1.1221	10	0.72032	D	0.01	-6.2231	11.951	0.52954	0.0:0.0:0.0:1.0	.	80	O15204	ADEC1_HUMAN	T	80;1;1	ENSP00000256412:M80T;ENSP00000442592:M1T;ENSP00000428993:M1T	ENSP00000256412:M80T	M	+	2	0	ADAMDEC1	24306751	0.994000	0.37717	0.862000	0.33874	0.265000	0.26407	3.640000	0.54350	2.069000	0.61940	0.460000	0.39030	ATG		0.303	ADAMDEC1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000215149.2	NM_014479		6	53	0	0	0	1	0	6	53				
DHX16	8449	broad.mit.edu	37	6	30633345	30633345	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A4UP-01A-11D-A257-08	TCGA-DJ-A4UP-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee4bf1b6-4123-4c18-987a-f814b572a708	eaf8980b-fe88-4642-ba40-8b94e462e275	g.chr6:30633345C>G	ENST00000376442.3	-	5	1027	c.832G>C	c.(832-834)Gat>Cat	p.D278H		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	278					mRNA processing (GO:0006397)|RNA splicing (GO:0008380)	nucleus (GO:0005634)	ATP binding (GO:0005524)|ATP-dependent helicase activity (GO:0008026)|poly(A) RNA binding (GO:0044822)|RNA helicase activity (GO:0003724)			kidney(2)|ovary(2)	4						CGGGCGAGATCCCGCACTCGC	0.632																																						uc003nqz.3																			0				kidney(2)|ovary(2)	4						c.(832-834)Gat>Cat		Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16), transcript variant 1, mRNA.							72.0	68.0	69.0					6																	30633345		1510	2709	4219	SO:0001583	missense	8449				RNA splicing|mRNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA helicase activity|nucleic acid binding	g.chr6:30633345C>G	AB001601	CCDS4685.1	6p21.3	2010-02-17	2003-06-13	2003-06-20	ENSG00000204560	ENSG00000204560		"""DEAH-boxes"""	2739	protein-coding gene	gene with protein product		603405	"""DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 16"""	DDX16		9547260	Standard	NM_003587		Approved	DBP2, Prp2, PRPF2	uc003nqz.3	O60231	OTTHUMG00000031060	ENST00000376442.3:c.832G>C	6.37:g.30633345C>G	ENSP00000365625:p.Asp278His					DHX16_uc011dmo.2_Missense_Mutation_p.D218H	p.D278H	NM_003587	NP_003578	O60231	DHX16_HUMAN			4	1044	-			278					O60322|Q5JP45|Q969X7|Q96QC1	Missense_Mutation	SNP	ENST00000376442.3	37	c.832G>C	CCDS4685.1	.	.	.	.	.	.	.	.	.	.	c	24.7	4.564033	0.86335	.	.	ENSG00000204560	ENST00000376442;ENST00000415603	T;T	0.51325	0.71;0.71	5.12	5.12	0.69794	.	0.102877	0.64402	D	0.000005	T	0.30759	0.0775	L	0.45051	1.395	0.80722	D	1	B;B	0.09022	0.002;0.002	B;B	0.13407	0.002;0.009	T	0.10245	-1.0638	10	0.51188	T	0.08	.	17.4724	0.87649	0.0:1.0:0.0:0.0	.	218;278	B4DZ28;O60231	.;DHX16_HUMAN	H	278;218	ENSP00000365625:D278H;ENSP00000399101:D218H	ENSP00000365625:D278H	D	-	1	0	DHX16	30741324	1.000000	0.71417	1.000000	0.80357	0.944000	0.59088	6.555000	0.73928	2.652000	0.90054	0.586000	0.80456	GAT		0.632	DHX16-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000076076.2	NM_003587		12	58	0	0	0	1	0	12	58				
ZNF74	7625	broad.mit.edu	37	22	20759722	20759722	+	Silent	SNP	G	G	A			TCGA-DJ-A4UP-01A-11D-A257-08	TCGA-DJ-A4UP-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee4bf1b6-4123-4c18-987a-f814b572a708	eaf8980b-fe88-4642-ba40-8b94e462e275	g.chr22:20759722G>A	ENST00000400451.2	+	5	913	c.399G>A	c.(397-399)ccG>ccA	p.P133P	ZNF74_ENST00000356671.5_Silent_p.P133P|ZNF74_ENST00000405993.1_Silent_p.P101P|ZNF74_ENST00000357502.5_Missense_Mutation_p.G139S|ZNF74_ENST00000403682.3_Missense_Mutation_p.G105S	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	133					multicellular organismal development (GO:0007275)|regulation of transcription, DNA-templated (GO:0006355)|transcription, DNA-templated (GO:0006351)	actin cytoskeleton (GO:0015629)|nucleus (GO:0005634)	DNA binding (GO:0003677)|metal ion binding (GO:0046872)|RNA binding (GO:0003723)|sequence-specific DNA binding transcription factor activity (GO:0003700)			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AAGAAGAACCGGCCCAGGAGC	0.627																																						uc010gsm.3																			0				central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19						c.(397-399)ccG>ccA		Homo sapiens zinc finger protein 74 (ZNF74), transcript variant 1, mRNA.							50.0	55.0	54.0					22																	20759722		1876	4089	5965	SO:0001819	synonymous_variant	7625				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding	g.chr22:20759722G>A	X71623	CCDS42982.1, CCDS58794.1	22q11.2	2013-01-08	2006-05-12		ENSG00000185252	ENSG00000185252		"""Zinc fingers, C2H2-type"", ""-"""	13144	protein-coding gene	gene with protein product		194548	"""zinc finger protein 74 (Cos52)"""			1639391, 10591208	Standard	NM_003426		Approved	Cos52, Zfp520, ZNF520	uc010gsm.4	Q16587	OTTHUMG00000150687	ENST00000400451.2:c.399G>A	22.37:g.20759722G>A						ZNF74_uc002zsg.3_Silent_p.P62P|ZNF74_uc002zsh.3_Silent_p.P133P|ZNF74_uc002zsi.3_Silent_p.P62P|ZNF74_uc010gsn.3_Silent_p.P62P	p.P133P	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)		5	611	+	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	133					B5MCE3|B7Z5Y2|Q6IBV2|Q6PJP1|Q9UC04|Q9UF05|Q9UF06|Q9UF07	Silent	SNP	ENST00000400451.2	37	c.399G>A	CCDS42982.1	.	.	.	.	.	.	.	.	.	.	G	5.677	0.309453	0.10733	.	.	ENSG00000185252	ENST00000403682;ENST00000357502	.	.	.	4.35	-8.7	0.00851	.	.	.	.	.	T	0.34424	0.0897	.	.	.	0.09310	N	1	.	.	.	.	.	.	T	0.53005	-0.8499	5	0.87932	D	0	-4.3214	5.9698	0.19346	0.1078:0.1602:0.4951:0.2369	.	.	.	.	S	105;139	.	ENSP00000350101:G139S	G	+	1	0	ZNF74	19089722	0.000000	0.05858	0.000000	0.03702	0.001000	0.01503	-6.314000	0.00071	-5.057000	0.00023	-1.872000	0.00552	GGC		0.627	ZNF74-005	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000319648.2	NM_003426		14	59	0	0	0	1	0	14	59				
ZXDA	7789	broad.mit.edu	37	X	57936633	57936633	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A4UP-01A-11D-A257-08	TCGA-DJ-A4UP-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee4bf1b6-4123-4c18-987a-f814b572a708	eaf8980b-fe88-4642-ba40-8b94e462e275	g.chrX:57936633G>C	ENST00000358697.4	-	1	434	c.222C>G	c.(220-222)ttC>ttG	p.F74L		NM_007156.4	NP_009087.1	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	74					positive regulation of transcription, DNA-templated (GO:0045893)|transcription, DNA-templated (GO:0006351)	nucleus (GO:0005634)	C2H2 zinc finger domain binding (GO:0070742)|metal ion binding (GO:0046872)|nucleic acid binding (GO:0003676)|sequence-specific DNA binding transcription factor activity (GO:0003700)			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|prostate(2)|skin(1)	37						GCCTCGGCGCGAACAGGCTTG	0.761													G|||	3	0.000794702	0.0	0.0029	3775	,	,		7034	0.001		0.0	False		,,,				2504	0.0					uc004dve.3																			0				breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|prostate(2)|skin(1)	37						c.(220-222)ttC>ttG		Homo sapiens zinc finger, X-linked, duplicated A (ZXDA), mRNA.							10.0	11.0	11.0					X																	57936633		2123	4175	6298	SO:0001583	missense	7789				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	g.chrX:57936633G>C	L14787	CCDS14376.1	Xp11.21	2013-01-08			ENSG00000198205	ENSG00000198205		"""Zinc fingers, C2H2-type"""	13198	protein-coding gene	gene with protein product	"""zinc finger protein 896"""	300235				8268913	Standard	NM_007156		Approved	ZNF896	uc004dve.3	P98168	OTTHUMG00000021688	ENST00000358697.4:c.222C>G	X.37:g.57936633G>C	ENSP00000351530:p.Phe74Leu						p.F74L	NM_007156	NP_009087	P98168	ZXDA_HUMAN			0	435	-			74					Q9UJP7	Missense_Mutation	SNP	ENST00000358697.4	37	c.222C>G	CCDS14376.1	.	.	.	.	.	.	.	.	.	.	.	0.003	-2.421410	0.00188	.	.	ENSG00000198205	ENST00000358697	T	0.20881	2.04	2.7	1.83	0.25207	.	0.366434	0.17474	N	0.172999	T	0.06234	0.0161	N	0.01352	-0.895	0.09310	N	1	B	0.02656	0.0	B	0.01281	0.0	T	0.40440	-0.9563	9	.	.	.	.	9.0185	0.36184	0.0:0.775:0.2249:0.0	.	74	P98168	ZXDA_HUMAN	L	74	ENSP00000351530:F74L	.	F	-	3	2	ZXDA	57953358	0.116000	0.22171	0.060000	0.19600	0.054000	0.15201	0.560000	0.23500	0.562000	0.29204	-0.777000	0.03380	TTC		0.761	ZXDA-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000056925.1	NM_007156		3	21	0	0	0	1	0	3	21				
HSPB6	126393	broad.mit.edu	37	19	36245363	36245363	+	IGR	SNP	C	C	T	rs539383447	byFrequency	TCGA-DJ-A4UP-01A-11D-A257-08	TCGA-DJ-A4UP-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ee4bf1b6-4123-4c18-987a-f814b572a708	eaf8980b-fe88-4642-ba40-8b94e462e275	g.chr19:36245363C>T	ENST00000592984.1	-	0	1634				LIN37_ENST00000301159.9_Silent_p.Y243Y|AC002398.11_ENST00000591091.1_RNA|AC002398.9_ENST00000591613.2_3'UTR|AC002398.12_ENST00000587767.1_RNA			O14558	HSPB6_HUMAN	heat shock protein, alpha-crystallin-related, B6						regulation of muscle contraction (GO:0006937)|response to stress (GO:0006950)	cytoplasm (GO:0005737)|nucleus (GO:0005634)	protein homodimerization activity (GO:0042803)|structural constituent of eye lens (GO:0005212)			lung(1)	1	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGAGATGTACGAACGACAGT	0.577													C|||	2	0.000399361	0.0008	0.0	5008	,	,		18745	0.001		0.0	False		,,,				2504	0.0					uc021usw.1																			0				large_intestine(1)|lung(5)	6						c.(727-729)taC>taT		Homo sapiens lin-37 homolog (C. elegans) (LIN37), mRNA.							59.0	61.0	60.0					19																	36245363		2037	4177	6214	SO:0001628	intergenic_variant	55957						protein binding	g.chr19:36245363C>T	AJ278121	CCDS12475.1	19q13.13	2014-06-12			ENSG00000004776	ENSG00000004776		"""Heat shock proteins / HSPB"""	26511	protein-coding gene	gene with protein product	"""protein phosphatase 1, regulatory subunit 91"""	610695				12820654, 14717697	Standard	NM_144617		Approved	FLJ32389, Hsp20, PPP1R91	uc002obn.2	O14558	OTTHUMG00000048122		19.37:g.36245363C>T						AL137752_uc002obl.3_5'Flank	p.Y243Y	NM_019104	NP_061977	Q96GY3	LIN37_HUMAN	LUSC - Lung squamous cell carcinoma(66;0.0515)		8	1093	+	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		243					O14551|Q6NVI3|Q96MG9	Silent	SNP	ENST00000592984.1	37	c.729C>T	CCDS12475.1																																																																																				0.577	HSPB6-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000109498.3	NM_144617		6	25	0	0	0	1	0	6	25				
