Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AVL9	23080	broad.mit.edu	37	7	32598232	32598232	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr7:32598232T>C	ENST00000318709.4	+	9	892	c.671T>C	c.(670-672)cTt>cCt	p.L224P	AVL9_ENST00000409301.1_Missense_Mutation_p.L224P|AVL9_ENST00000404479.1_Missense_Mutation_p.L224P	NM_015060.1	NP_055875.1	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	224						integral to membrane				endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						GTGTTATCCCTTTTTCCAGGT	0.328000													3	174					0	0	0.115264	0	0
GNGT1	2792	broad.mit.edu	37	7	93540201	93540201	+	Missense_Mutation	SNP	G	G	C			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr7:93540201G>C	ENST00000248572.5	+	3	344	c.196G>C	c.(196-198)Gag>Cag	p.E66Q	GNGT1_ENST00000429473.1_Missense_Mutation_p.E66Q|GNGT1_ENST00000455502.1_3'UTR	NM_021955.3	NP_068774.1	P63211	GBG1_HUMAN	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	66					G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|signal transducer activity			endometrium(1)|large_intestine(1)|lung(3)|prostate(1)	6	all_cancers(62;2.39e-10)|all_epithelial(64;1.54e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			TCCCTTCAAGGAGCTCAAAGG	0.348000													5	84					0	0	0.184627	0	0
CPE	1363	broad.mit.edu	37	4	166403472	166403472	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr4:166403472G>A	ENST00000402744.4	+	4	1031	c.751G>A	c.(751-753)Gac>Aac	p.D251N		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	251					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCATGGAGGAGACCTTGTGGC	0.403000													4	151					0	0	0.150653	0	0
EIF1AX	1964	broad.mit.edu	37	X	20156731	20156731	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chrX:20156731C>T	ENST00000379607.5	-	2	229	c.26G>A	c.(25-27)gGt>gAt	p.G9D	EIF1AX_ENST00000379593.1_Intron	NM_001412.3	NP_001403.1	P47813	IF1AX_HUMAN	eukaryotic translation initiation factor 1A, X-linked	9						cytosol	translation initiation factor activity			endometrium(2)|lung(1)|ovary(1)|prostate(1)	5						TCTGTTTTTACCTCCTTTACC	0.313000													63	38					0	0	0.870114	0	0
SNHG14	0	broad.mit.edu	37	15	25332998	25332998	+	RNA	SNP	C	C	T	rs3825775		TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr15:25332998C>T	ENST00000546682.1	+	0	586				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						AATGTGGTCTCTTATGGGTGA	0.483000													23	42					0	0	0.608945	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998408	8998408	+	Missense_Mutation	SNP	A	A	T			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr8:8998408A>T	ENST00000310455.3	-	2	904	c.754T>A	c.(754-756)Ttg>Atg	p.L252M	PPP1R3B_ENST00000519699.1_Missense_Mutation_p.L252M	NM_001201329.1|NM_024607.3	NP_001188258.1|NP_078883.2	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory subunit 3B	252					glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		GATATTCCCAAATCCGGTCCA	0.498000													14	90					0	0	0.479597	0	0
ANO4	121601	broad.mit.edu	37	12	101520843	101520843	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr12:101520843C>T	ENST00000392979.3	+	26	3119	c.2758C>T	c.(2758-2760)Ccg>Tcg	p.P920S	ANO4_ENST00000392977.3_Missense_Mutation_p.P955S|ANO4_ENST00000550015.1_Missense_Mutation_p.P475S|ANO4_ENST00000299222.9_Missense_Mutation_p.P475S	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	955						chloride channel complex	chloride channel activity	p.P920S(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CAACGAGTGGCCGTGACCATG	0.488000										HNSCC(74;0.22)			3	46					0	0	0.115264	0	0
MYO5C	55930	broad.mit.edu	37	15	52486124	52486124	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr15:52486124T>C	ENST00000261839.7	-	41	5365	c.5204A>G	c.(5203-5205)aAg>aGg	p.K1735R	RP11-430B1.2_ENST00000560518.1_lincRNA	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	1735						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		AAAGCCTAGCTTGAAACTGCT	0.383000													21	221					0	0	0.624587	0	0
SUPT6H	6830	broad.mit.edu	37	17	27008399	27008399	+	Missense_Mutation	SNP	T	T	C			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr17:27008399T>C	ENST00000314616.6	+	12	1758	c.1475T>C	c.(1474-1476)gTc>gCc	p.V492A	SUPT6H_ENST00000347486.4_Missense_Mutation_p.V492A	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	492					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					CTGAAGCGTGTCAGGGAAGAG	0.468000													3	92					0	0	0.115264	0	0
CLIP3	25999	broad.mit.edu	37	19	36509847	36509847	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr19:36509847C>T	ENST00000360535.4	-	9	1363	c.1136G>A	c.(1135-1137)cGg>cAg	p.R379Q	AC002116.7_ENST00000586962.1_RNA|CLIP3_ENST00000593074.1_Missense_Mutation_p.R379Q	NM_015526.2	NP_056341.1	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	379					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GAAGTCCATCCGGGGGGTCCG	0.612000													19	135					0	0	0.608945	0	0
LAMA5	3911	broad.mit.edu	37	20	60910087	60910087	+	Missense_Mutation	SNP	A	A	C			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr20:60910087A>C	ENST00000252999.3	-	20	2538	c.2472T>G	c.(2470-2472)ttT>ttG	p.F824L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	824	Laminin EGF-like 10.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCGGCAGCCAAAATAGTCAG	0.652000													3	55					0	0	0.115264	0	0
TTC14	151613	broad.mit.edu	37	3	180324339	180324339	+	Missense_Mutation	SNP	C	C	G			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr3:180324339C>G	ENST00000412756.2	+	9	1189	c.1120C>G	c.(1120-1122)Cac>Gac	p.H374D	TTC14_ENST00000382584.4_Missense_Mutation_p.H374D|TTC14_ENST00000296015.4_Missense_Mutation_p.H374D	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	374							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CTGTCCAACTCACAGAAATGC	0.383000													4	196					0	0	0.150653	0	0
NOP56	10528	broad.mit.edu	37	20	2635156	2635156	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr20:2635156C>T	ENST00000329276.5	+	4	821	c.305C>T	c.(304-306)gCc>gTc	p.A102V		NM_006392.3	NP_006383.2	O00567	NOP56_HUMAN	NOP56 ribonucleoprotein	102					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25						AAGATTGGTGCCGCAATACAG	0.517000													4	185					0	0	0.150653	0	0
CHD9	80205	broad.mit.edu	37	16	53243396	53243396	+	Silent	SNP	T	T	C			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr16:53243396T>C	ENST00000566029.1	+	3	1664	c.1455T>C	c.(1453-1455)ccT>ccC	p.P485P	CHD9_ENST00000398510.3_Silent_p.P485P|CHD9_ENST00000564845.1_Silent_p.P485P|CHD9_ENST00000447540.1_Silent_p.P485P			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	485					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				TTCTGTAGCCTCCATCTTCCA	0.343000													3	33					0	0	0.150653	0	0
ABCD1	215	broad.mit.edu	37	X	152991197	152991197	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chrX:152991197C>T	ENST00000218104.3	+	1	875	c.476C>T	c.(475-477)gCc>gTc	p.A159V		NM_000033.3	NP_000024.2	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member 1	159	ABC transmembrane type-1.|Interaction with PEX19.				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(2)	18	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGCCAACTGGCCCTGTCGTTC	0.647000													3	39					0	0	0.115264	0	0
CDK11A	728642	broad.mit.edu	37	1	1635515	1635515	+	Missense_Mutation	SNP	T	T	A	rs56410233		TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr1:1635515T>A	ENST00000356200.3	-	15	1889	c.1655A>T	c.(1654-1656)cAg>cTg	p.Q552L	CDK11A_ENST00000357760.2_Missense_Mutation_p.Q585L|CDK11A_ENST00000495016.1_Intron|CDK11A_ENST00000358779.5_Missense_Mutation_p.Q576L|RP1-283E3.8_ENST00000598846.1_RNA|CDK11A_ENST00000378638.2_Missense_Mutation_p.Q552L|CDK11A_ENST00000404249.3_Missense_Mutation_p.Q586L|CDK11A_ENST00000378633.1_Missense_Mutation_p.Q589L					cyclin-dependent kinase 11A									p.Q585L(1)		central_nervous_system(1)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(4)|stomach(1)|urinary_tract(1)	18						GCGGTACCACTGGGTCACCAC	0.672000													4	43					0	0	0.184627	0	0
TRMT5	57570	broad.mit.edu	37	14	61442344	61442344	+	Silent	SNP	A	A	C			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr14:61442344A>C	ENST00000261249.6	-	4	1677	c.1293T>G	c.(1291-1293)gtT>gtG	p.V431V	RP11-193F5.1_ENST00000553946.1_RNA	NM_020810.2	NP_065861.2	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	431						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(1)	11				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		CCCTTTGCCGAACATCCTCAG	0.483000													8	148					0	0	0.335167	0	0
KRTAP13-4	284827	broad.mit.edu	37	21	31802980	31802980	+	Silent	SNP	C	C	A			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr21:31802980C>A	ENST00000334068.2	+	1	409	c.387C>A	c.(385-387)tcC>tcA	p.S129S		NM_181600.1	NP_853631.1	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	129						intermediate filament				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	15						GTTACGGATCCAGATTCTGCT	0.473000													8	105					5.18039e-06	6.3136e-06	0.278610	1	0
GOLGA4	2803	broad.mit.edu	37	3	37368937	37368937	+	Missense_Mutation	SNP	C	C	A			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr3:37368937C>A	ENST00000361924.2	+	14	5934	c.5560C>A	c.(5560-5562)Caa>Aaa	p.Q1854K	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.Q1876K	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1854	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GATTTTGGAGCAAAAGATAAA	0.373000													4	98					0.00909568	0.0107494	0.150653	1	0
BMS1	9790	broad.mit.edu	37	10	43287074	43287074	+	Splice_Site	SNP	G	G	T			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr10:43287074G>T	ENST00000374518.4	+	6	699		c.e6-1			NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor						ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CTAATGTTTAGGGTGCCAAGC	0.338000													4	135					0.150653	0.167871	0.150653	1	0
TRPC4	7223	broad.mit.edu	37	13	38357334	38357334	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr13:38357334G>A	ENST00000379705.3	-	2	994	c.137C>T	c.(136-138)gCc>gTc	p.A46V	TRPC4_ENST00000358477.2_Missense_Mutation_p.A46V|TRPC4_ENST00000426868.2_Missense_Mutation_p.A46V|TRPC4_ENST00000379679.1_Missense_Mutation_p.A46V|TRPC4_ENST00000338947.5_Missense_Mutation_p.A46V|TRPC4_ENST00000355779.2_Missense_Mutation_p.A46V|TRPC4_ENST00000379673.2_Missense_Mutation_p.A46V|TRPC4_ENST00000379681.3_Missense_Mutation_p.A46V|TRPC4_ENST00000447043.1_Missense_Mutation_p.A46V			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	46					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity	p.A46V(2)		NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CTTGACACTGGCATAATCTCC	0.403000													5	339					0	0	0.184627	0	0
ZNF790	388536	broad.mit.edu	37	19	37309574	37309574	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr19:37309574C>T	ENST00000356725.4	-	5	1792	c.1672G>A	c.(1672-1674)Gat>Aat	p.D558N	CTD-2162K18.5_ENST00000588906.1_RNA|CTD-2162K18.5_ENST00000587278.1_RNA	NM_001242802.1|NM_206894.3	NP_001229731.1|NP_996777.2	Q6PG37	ZN790_HUMAN	zinc finger protein 790	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	32	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GGTTCTGCATCAGTATGAATT	0.358000													8	239					0	0	0.278610	0	0
TRAV9-2	0	broad.mit.edu	37	14	22409767	22409767	+	RNA	SNP	G	G	A			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr14:22409767G>A	ENST00000390441.2	+	0	313																											GCCACATACCGTAAAGAAACC	0.483000													15	99					0	0	0.520397	0	0
OR52N1	79473	broad.mit.edu	37	11	5809691	5809691	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr11:5809691A>G	ENST00000317078.1	-	1	355	c.356T>C	c.(355-357)cTc>cCc	p.L119P	TRIM5_ENST00000380027.1_Intron	NM_001001913.1	NP_001001913.1	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N, member 1	119					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(15)|prostate(2)|skin(3)	31		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		CAGGGCCATGAGCATGAGCAC	0.488000													3	179					0	0	0.115264	0	0
PDZD8	118987	broad.mit.edu	37	10	119043929	119043929	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr10:119043929C>T	ENST00000334464.5	-	5	2554	c.2315G>A	c.(2314-2316)cGc>cAc	p.R772H	PDZD8_ENST00000482496.1_5'UTR	NM_173791.3	NP_776152.1	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	772					intracellular signal transduction		metal ion binding			kidney(3)|large_intestine(8)|lung(24)|upper_aerodigestive_tract(3)	38		Colorectal(252;0.19)		all cancers(201;0.0121)		ACTCAGATTGCGTAGTGCGGT	0.413000													4	157					0	0	0.150653	0	0
SMUG1	23583	broad.mit.edu	37	12	54576295	54576295	+	Missense_Mutation	SNP	T	T	A			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr12:54576295T>A	ENST00000508394.2	-	3	460	c.398A>T	c.(397-399)cAg>cTg	p.Q133L	SMUG1_ENST00000243112.5_Missense_Mutation_p.Q133L|SMUG1_ENST00000514196.1_Missense_Mutation_p.Q133L|SMUG1_ENST00000505128.1_3'UTR|SMUG1_ENST00000514685.1_Missense_Mutation_p.Q133L|SMUG1_ENST00000513838.1_Missense_Mutation_p.Q133L|SMUG1_ENST00000505662.1_5'UTR|SMUG1_ENST00000337581.3_Missense_Mutation_p.Q133L|SMUG1_ENST00000506595.1_Missense_Mutation_p.Q133L|SMUG1_ENST00000401977.2_Missense_Mutation_p.Q133L	NM_001243787.1|NM_001243788.1|NM_014311.2	NP_001230716.1|NP_001230717.1|NP_055126.1	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional uracil-DNA glycosylase 1	133				Missing (in Ref. 3; BAC03670).	depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity			kidney(1)|large_intestine(4)|lung(1)	6						CACTTCTGACTGTGGGCACTC	0.562000								Base excision repair (BER), DNA glycosylases					20	313					0	0	0.557998	0	0
MICAL1	64780	broad.mit.edu	37	6	109769507	109769507	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr6:109769507A>G	ENST00000368952.4	-	13	2101	c.1811T>C	c.(1810-1812)gTg>gCg	p.V604A	MICAL1_ENST00000358807.3_Missense_Mutation_p.V585A|MICAL1_ENST00000358577.3_Missense_Mutation_p.V499A			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	585	CH.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		TGCAGACACCACCGGTGTGAT	0.607000													7	392					0	0	0.335167	0	0
THOC5	8563	broad.mit.edu	37	22	29939458	29939458	+	Missense_Mutation	SNP	G	G	A			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr22:29939458G>A	ENST00000490103.1	-	4	436	c.314C>T	c.(313-315)gCc>gTc	p.A105V	THOC5_ENST00000397871.1_Missense_Mutation_p.A105V|THOC5_ENST00000397872.1_Missense_Mutation_p.A105V|THOC5_ENST00000397873.2_Missense_Mutation_p.A105V	NM_003678.4	NP_003669.4	Q13769	THOC5_HUMAN	THO complex 5	105	Interaction with CSF1R (By similarity).|Interaction with THOC7.				intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(4)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CCTGATGTGGGCTAATCGGTT	0.438000													4	168					0	0	0.184627	0	0
LINC00613	0	broad.mit.edu	37	4	136806779	136806782	+	RNA	DEL	TGTG	TGTG	-	rs72272662		TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr4:136806779_136806782delTGTG	ENST00000504365.1	-	0	120					NR_103762.1																						GAATACATCCtgtgtgtgtgtgtg	0.426													2	4	---	---	---	---					
KCNN2	3781	broad.mit.edu	37	5	113698631	113698632	+	In_Frame_Ins	INS	-	-	GCC	rs34838882	by1000genomes	TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr5:113698631_113698632insGCC	ENST00000512097.3	+	2	1177_1178	c.159_160insGCC	c.(157-162)gcccgc>gcGCCccgc	p.53_54AR>APR	KCNN2_ENST00000264773.3_In_Frame_Ins_p.53_54AR>APR			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	53	Poly-Ala.					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CTGCAGCCGCTGCCGCCGCCGC	0.703													3	4	---	---	---	---					
TBC1D3P5	0	broad.mit.edu	37	17	25754047	25754047	+	RNA	DEL	T	T	-			TCGA-BJ-A0ZG-01A-11D-A10S-08	TCGA-BJ-A0ZG-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36359097-f78d-46ea-9944-0f763b96f6dc	00b180fc-6158-4ed3-a8b3-2ef314e66bd1	g.chr17:25754047delT	ENST00000586223.1	+	0	1595					NR_033892.1																						GACGCTGTTCTTttttttttt	0.453													3	6	---	---	---	---					
