Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FRG1B	0	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P|FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													9	143					0	0	1	0	0
C16orf98	100652740	broad.mit.edu	37	16	31214039	31214039	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr16:31214039C>T	ENST00000561916.2	+	2	361	c.265C>T	c.(265-267)Cgc>Tgc	p.R89C	PYCARD_ENST00000350605.4_5'UTR|PYCARD_ENST00000247470.9_5'UTR					chromosome 16 open reading frame 98																		CCGCTGCCGCCGCTCACCCCG	0.721000													3	23					0	0	1	0	0
TP73-AS1	0	broad.mit.edu	37	1	3662614	3662614	+	RNA	SNP	G	G	A			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr1:3662614G>A	ENST00000452079.1	-	0	1272				TP73-AS1_ENST00000418088.1_RNA|TP73-AS1_ENST00000544565.1_RNA|TP73-AS1_ENST00000423764.1_RNA	NR_033711.1																						AGAGACGTGTGGCCCACAGCG	0.652000													9	97					0	0	1	0	0
NBEAP1	0	broad.mit.edu	37	15	20876518	20876518	+	RNA	SNP	C	C	T			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr15:20876518C>T	ENST00000556948.1	-	0	82																											CAAAGGTACTCCATGAGATAA	0.338000													12	61					0	0	1	0	0
RPL36AL	6166	broad.mit.edu	37	14	50085726	50085726	+	Missense_Mutation	SNP	A	A	C			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr14:50085726A>C	ENST00000298289.6	-	2	256	c.97T>G	c.(97-99)Ttg>Gtg	p.L33V		NM_001001.4	NP_000992.1	Q969Q0	RL36L_HUMAN	ribosomal protein L36a-like	33					translation	ribosome	structural constituent of ribosome					all_epithelial(31;0.0021)|Breast(41;0.0124)					TGGGCATACAAAGAATCCTTG	0.473000													38	85					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2290333	2290333	+	Missense_Mutation	SNP	C	C	A	rs214803	byFrequency	TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr20:2290333C>A	ENST00000381458.5	+	2	101	c.38C>A	c.(37-39)aCg>aAg	p.T13K		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	13			T -> K (in dbSNP:rs214803).		cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity	p.T13M(1)		breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	AACTGGCAGACGGCCTTCAAC	0.522000													6	117					0.00116845	0.00126192	1	1	0
KIF1A	547	broad.mit.edu	37	2	241710459	241710459	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr2:241710459C>T	ENST00000498729.2	-	15	1516	c.1270G>A	c.(1270-1272)Gcc>Acc	p.A424T	KIF1A_ENST00000320389.7_Missense_Mutation_p.A415T	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	415					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GACACGGAGGCCGCGCGGCTG	0.647000													6	66					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292819	102292819	+	RNA	SNP	C	C	T			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr15:102292819C>T	ENST00000561463.1	+	0	865																											CGCGTGGGAACGAGAAGACAC	0.592000													3	31					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430827	43430827	+	RNA	SNP	G	G	A			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr19:43430827G>A	ENST00000446844.3	-	0	840				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TTCTCCCTGGGGTTTAAGTTA	0.488000													13	275					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94841744	94841744	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr15:94841744A>G	ENST00000357742.4	+	1	250	c.250A>G	c.(250-252)Act>Gct	p.T84A	MCTP2_ENST00000543482.1_Missense_Mutation_p.T84A|MCTP2_ENST00000451018.3_Missense_Mutation_p.T84A|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	84					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CAGTCTGTCCACTGCAGGGAT	0.582000													8	98					0	0	1	0	0
PLGLA	0	broad.mit.edu	37	2	107007467	107007467	+	RNA	SNP	G	G	A	rs7575679	by1000genomes	TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr2:107007467G>A	ENST00000484422.1	+	0	316																											ACTTCTCCCCGCAGACCTAGG	0.468000													4	29					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				21	38					0	0	1	0	0
C16orf98	100652740	broad.mit.edu	37	16	31214039	31214039	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr16:31214039C>T	ENST00000561916.2	+	2	361	c.265C>T	c.(265-267)Cgc>Tgc	p.R89C	PYCARD_ENST00000350605.4_5'UTR|PYCARD_ENST00000247470.9_5'UTR					chromosome 16 open reading frame 98																		CCGCTGCCGCCGCTCACCCCG	0.721000													3	23					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182812436	182812436	+	Missense_Mutation	SNP	T	T	G			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr1:182812436T>G	ENST00000367549.3	+	3	229	c.119T>G	c.(118-120)gTg>gGg	p.V40G		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	40	DRBM 1.|Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding	p.V40G(8)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						AAGGTTCAGGTGGAAGGTTAT	0.333000													7	27					0	0	1	0	0
HERC2P3	0	broad.mit.edu	37	15	20588571	20588571	+	RNA	SNP	T	T	G	rs113432051	by1000genomes	TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr15:20588571T>G	ENST00000428453.1	-	0	4179																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						AGAAGCCCAGTAGGCATCCAC	0.448000													6	79					0	0	1	0	0
RPL36AL	6166	broad.mit.edu	37	14	50085726	50085726	+	Missense_Mutation	SNP	A	A	C			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr14:50085726A>C	ENST00000298289.6	-	2	256	c.97T>G	c.(97-99)Ttg>Gtg	p.L33V		NM_001001.4	NP_000992.1	Q969Q0	RL36L_HUMAN	ribosomal protein L36a-like	33					translation	ribosome	structural constituent of ribosome					all_epithelial(31;0.0021)|Breast(41;0.0124)					TGGGCATACAAAGAATCCTTG	0.473000													38	85					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241710459	241710459	+	Missense_Mutation	SNP	C	C	T			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr2:241710459C>T	ENST00000498729.2	-	15	1516	c.1270G>A	c.(1270-1272)Gcc>Acc	p.A424T	KIF1A_ENST00000320389.7_Missense_Mutation_p.A415T	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	415					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GACACGGAGGCCGCGCGGCTG	0.647000													6	66					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292819	102292819	+	RNA	SNP	C	C	T			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr15:102292819C>T	ENST00000561463.1	+	0	865																											CGCGTGGGAACGAGAAGACAC	0.592000													3	31					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430827	43430827	+	RNA	SNP	G	G	A			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr19:43430827G>A	ENST00000446844.3	-	0	840				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TTCTCCCTGGGGTTTAAGTTA	0.488000													13	275					0	0	1	0	0
TP73-AS1	0	broad.mit.edu	37	1	3662614	3662614	+	RNA	SNP	G	G	A			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr1:3662614G>A	ENST00000452079.1	-	0	1272				TP73-AS1_ENST00000418088.1_RNA|TP73-AS1_ENST00000544565.1_RNA|TP73-AS1_ENST00000423764.1_RNA	NR_033711.1																						AGAGACGTGTGGCCCACAGCG	0.652000													9	97					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94841744	94841744	+	Missense_Mutation	SNP	A	A	G			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr15:94841744A>G	ENST00000357742.4	+	1	250	c.250A>G	c.(250-252)Act>Gct	p.T84A	MCTP2_ENST00000543482.1_Missense_Mutation_p.T84A|MCTP2_ENST00000451018.3_Missense_Mutation_p.T84A|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	84					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CAGTCTGTCCACTGCAGGGAT	0.582000													8	98					0	0	1	0	0
PLGLA	0	broad.mit.edu	37	2	107007467	107007467	+	RNA	SNP	G	G	A	rs7575679	by1000genomes	TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr2:107007467G>A	ENST00000484422.1	+	0	316																											ACTTCTCCCCGCAGACCTAGG	0.468000													4	29					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				21	38					0	0	1	0	0
COMT	1312	broad.mit.edu	37	22	19951897	19951897	+	Missense_Mutation	SNP	G	G	C	rs4646315	byFrequency	TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr22:19951897G>C	ENST00000403184.1	+	5	946	c.690G>C	c.(688-690)aaG>aaC	p.K230N	COMT_ENST00000361682.6_Intron|COMT_ENST00000407537.1_Intron|COMT_ENST00000406520.3_Intron|COMT_ENST00000403710.1_Intron|COMT_ENST00000449653.1_Intron			P21964	COMT_HUMAN	catechol-O-methyltransferase	0					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			kidney(1)|lung(1)|ovary(1)|prostate(1)|stomach(1)	5	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	CCTCTCCAAAGAGCCAGGCAT	0.632000													3	25					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74575212	74575213	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr1:74575212_74575213insT	ENST00000354431.4	-	5	923_924	c.732_733insA	c.(730-735)aaagcafs	p.A245fs	LRRIQ3_ENST00000370909.2_Frame_Shift_Ins_p.A137fs|LRRIQ3_ENST00000395089.1_Frame_Shift_Ins_p.A245fs|LRRIQ3_ENST00000468759.1_5'UTR	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	245				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTTTCCTGCTGTTTTTTTTTGT	0.327													7	61	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20086382	20086383	+	RNA	INS	-	-	AAAA			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr14:20086382_20086383insAAAA	ENST00000548261.1	+	0	135																											TCTTACAAGGTAAAAAAAATGA	0.312													3	5	---	---	---	---					
ZNF880	400713	broad.mit.edu	37	19	52877717	52877717	+	Frame_Shift_Del	DEL	T	T	-	rs77187934		TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chr19:52877717delT	ENST00000597976.1	+	3	325	c.305delT	c.(304-306)atfs	p.I102fs	ZNF880_ENST00000600321.1_Intron|ZNF880_ENST00000424032.2_Intron|ZNF880_ENST00000344085.5_Intron|ZNF880_ENST00000422689.2_Intron			Q6PDB4	ZN880_HUMAN	zinc finger protein 880	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	10						GGCCCCATAAttttttttttt	0.473													5	9	---	---	---	---					
FAAH2	158584	broad.mit.edu	37	X	57358200	57358200	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	de1c5006-a002-47f6-b7a4-0fa3ed4a1cc5	g.chrX:57358200delC	ENST00000374900.4	+	4	702	c.582delC	c.(580-582)aafs	p.N195fs		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	195						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						GCCGATCAAACAACCCATATG	0.388										HNSCC(52;0.14)			9	87	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chr16:3119304_3119305insG	ENST00000525643.2	+	7	847_848	c.515_516insG	c.(514-516)gaafs	p.E172fs	IL32_ENST00000530890.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000440815.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000396890.2_Frame_Shift_Ins_p.E218fs|IL32_ENST00000382213.3_Frame_Shift_Ins_p.E163fs|IL32_ENST00000528163.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000533097.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000529550.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000548246.1_Frame_Shift_Ins_p.E132fs|IL32_ENST00000552664.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000548476.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000526464.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000531965.1_Frame_Shift_Ins_p.E162fs|IL32_ENST00000548652.1_Frame_Shift_Ins_p.E163fs|IL32_ENST00000534507.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000549213.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000444393.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000551513.1_Frame_Shift_Ins_p.E209fs|IL32_ENST00000396887.3_Frame_Shift_Ins_p.E115fs|IL32_ENST00000551122.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000530538.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000529699.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000552936.1_Frame_Shift_Ins_p.E196fs|IL32_ENST00000552356.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000325568.5_Frame_Shift_Ins_p.E172fs|IL32_ENST00000008180.9_Frame_Shift_Ins_p.E152fs			P24001	IL32_HUMAN	interleukin 32	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						CCACGGGGGGACAAGGAGGAGC	0.574													16	213	---	---	---	---					
FAAH2	158584	broad.mit.edu	37	X	57358200	57358200	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BJ-A4O8-01A-11D-A257-08	TCGA-BJ-A4O8-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c6163b00-1858-4448-a2ae-449c8c5f4d59	73a63ebc-f5e7-4f82-9767-572a4d623cad	g.chrX:57358200delC	ENST00000374900.4	+	4	702	c.582delC	c.(580-582)aafs	p.N195fs		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	195						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						GCCGATCAAACAACCCATATG	0.388										HNSCC(52;0.14)			9	87	---	---	---	---					
