Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RBM47	54502	broad.mit.edu	37	4	40434683	40434683	+	Silent	SNP	C	C	T			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr4:40434683C>T	ENST00000319592.4	-	5	2029	c.1320G>A	c.(1318-1320)acG>acA	p.T440T	RBM47_ENST00000381795.6_Silent_p.T440T|RBM47_ENST00000514014.1_Silent_p.T471T|RBM47_ENST00000381793.2_Silent_p.T509T|RBM47_ENST00000295971.7_Silent_p.T509T			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	509						nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						AAGGTGGTGGCGTCGACACAG	0.552000													7	132					0	0	1	0	0
SUV39H2	79723	broad.mit.edu	37	10	14923614	14923614	+	Silent	SNP	G	G	A			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr10:14923614G>A	ENST00000378325.3	+	2	173	c.147G>A	c.(145-147)gtG>gtA	p.V49V	SUV39H2_ENST00000313519.5_Intron|SUV39H2_ENST00000354919.6_Silent_p.V49V	NM_001193426.1|NM_001193427.1	NP_001180355.1|NP_001180356.1	Q9H5I1	SUV92_HUMAN	suppressor of variegation 3-9 homolog 2 (Drosophila)	49	Chromo.				cell cycle|cell differentiation|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|chromosome, centromeric region|nucleus	histone methyltransferase activity (H3-K9 specific)|protein binding|zinc ion binding	p.V49V(1)		breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)	19						ATTATGAGGTGGAATACTTGT	0.353000													31	74					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196746684	196746684	+	Silent	SNP	T	T	C			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr2:196746684T>C	ENST00000312428.6	-	36	5896	c.5796A>G	c.(5794-5796)aaA>aaG	p.K1932K		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1932					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTTCTTTCAATTTCTTTATCC	0.338000													12	28					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214832258	214832258	+	Silent	SNP	C	C	A			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr1:214832258C>A	ENST00000366955.3	+	19	9196	c.9028C>A	c.(9028-9030)Cgg>Agg	p.R3010R		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	3106	Sufficient for centromere localization.|Sufficient for nuclear localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CATGGCAACTCGGACCAGCCC	0.522000											OREG0014250	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	132					0.184627	0.184627	1	1	0
CROCCP2	0	broad.mit.edu	37	1	16956534	16956534	+	RNA	SNP	C	C	T			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr1:16956534C>T	ENST00000412962.1	-	0	294																											GACGGCGCCACGCAGGTGTTC	0.602000													7	51					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57187780	57187780	+	Missense_Mutation	SNP	A	A	C			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr7:57187780A>C	ENST00000331162.4	-	5	1612	c.1342T>G	c.(1342-1344)Tta>Gta	p.L448V		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			GTTGAGGATAAGCTAAAGGCT	0.438000													4	64					0	0	1	0	0
SDS	10993	broad.mit.edu	37	12	113835178	113835178	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr12:113835178C>T	ENST00000257549.4	-	6	567	c.445G>A	c.(445-447)Gtg>Atg	p.V149M		NM_006843.2	NP_006834.2	P20132	SDHL_HUMAN	serine dehydratase	149					gluconeogenesis|L-serine catabolic process|pyruvate biosynthetic process	cytoplasm	L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|protein homodimerization activity|pyridoxal phosphate binding			large_intestine(2)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(1)	11					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AGCTCTTTCACGATGGAAGCG	0.657000													29	65					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103868	53103868	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr7:53103868G>T	ENST00000408890.4	+	1	520	c.504G>T	c.(502-504)gaG>gaT	p.E168D		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	168										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						ccgcccAGGAGCTCCTGGACC	0.721000													14	25					4.3838e-07	4.7345e-07	1	1	0
RBM12B	389677	broad.mit.edu	37	8	94747845	94747845	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr8:94747845C>T	ENST00000399300.2	-	3	1007	c.794G>A	c.(793-795)cGa>cAa	p.R265Q	RBM12B_ENST00000517700.1_Missense_Mutation_p.R265Q|RBM12B_ENST00000520961.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	265							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			AGACCGTTTTCGAAAATGTCT	0.403000													27	46					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661272	22661272	+	RNA	SNP	C	C	T			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr22:22661272C>T	ENST00000426066.1	+	0	360					NR_027293.1																						CTGGGATGTACGTCTGCGTTG	0.488000													4	62					0	0	1	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554340	85554340	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr2:85554340G>A	ENST00000377386.3	-	2	977	c.515C>T	c.(514-516)gCg>gTg	p.A172V	TGOLN2_ENST00000444342.2_Missense_Mutation_p.A172V|TGOLN2_ENST00000282120.2_Missense_Mutation_p.A74V|TGOLN2_ENST00000409015.1_Missense_Mutation_p.A172V|TGOLN2_ENST00000398263.2_Missense_Mutation_p.A172V|TGOLN2_ENST00000409232.3_Missense_Mutation_p.A172V			O43493	TGON2_HUMAN	trans-golgi network protein 2	172	14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										TGTGGTCTGCGCCTCCGAACC	0.597000													43	528					0	0	1	0	0
FRMD6	122786	broad.mit.edu	37	14	52188751	52188751	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr14:52188751A>G	ENST00000395718.2	+	12	1706	c.1421A>G	c.(1420-1422)tAc>tGc	p.Y474C	FRMD6_ENST00000344768.5_Missense_Mutation_p.Y482C|FRMD6_ENST00000554167.1_Missense_Mutation_p.Y405C|FRMD6_ENST00000356218.4_Missense_Mutation_p.Y474C|FRMD6_ENST00000553556.1_Missense_Mutation_p.Y124C	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	482						cytoskeleton|mitochondrion|plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					ATGTGCATCTACATCACAGAG	0.493000													4	54					0	0	1	0	0
GSN	2934	broad.mit.edu	37	9	124062285	124062285	+	Splice_Site	SNP	T	T	G			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr9:124062285T>G	ENST00000373818.4	+	1	213		c.e1+2		GSN_ENST00000412819.1_Intron|GSN_ENST00000373808.2_Intron|GSN_ENST00000449733.1_Intron|GSN_ENST00000341272.2_Intron|GSN_ENST00000373823.3_Intron|GSN_ENST00000436847.1_Intron|GSN_ENST00000394353.2_Intron|GSN_ENST00000545652.1_Intron	NM_000177.4|NM_001258029.1	NP_000168.1|NP_001244958.1	P06396	GELS_HUMAN	gelsolin						actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						gaggcgcgggtgagtgcccgg	0.697000													9	20					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87446746	87446746	+	Silent	SNP	G	G	C			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr16:87446746G>C	ENST00000268616.4	-	11	1465	c.1248C>G	c.(1246-1248)tcC>tcG	p.S416S		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	416					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		AGTACTCCGAGGAACTGCCTT	0.642000													4	18					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350361	100350361	+	RNA	SNP	T	T	C			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr7:100350361T>C	ENST00000542585.1	+	0	2781				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACGGAAAAACTCACCATCCCC	0.502000													7	157					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	24					0	0	1	0	0
AKR1C3	8644	broad.mit.edu	37	10	5136713	5136713	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr10:5136713C>A	ENST00000380554.3	+	1	729	c.77C>A	c.(76-78)cCt>cAt	p.P26H	AKR1C3_ENST00000605149.1_Intron|AKR1C3_ENST00000439082.2_Intron|AKR1C3_ENST00000470862.2_Intron	NM_001253908.1|NM_003739.5	NP_001240837.1|NP_003730.4	P42330	AK1C3_HUMAN	aldo-keto reductase family 1, member C3	26					prostaglandin metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (A-specific) activity|indanol dehydrogenase activity|prostaglandin-F synthase activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|skin(1)	14					Dimethyl sulfoxide(DB01093)|NADH(DB00157)	ACCTATGCACCTCCAGAGGTA	0.418000													4	143					0.150653	0.156448	1	1	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				32	49					0	0	1	0	0
TYRO3	7301	broad.mit.edu	37	15	41862822	41862822	+	Missense_Mutation	SNP	G	G	A	rs142874537		TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr15:41862822G>A	ENST00000263798.3	+	12	1728	c.1504G>A	c.(1504-1506)Gat>Aat	p.D502N	TYRO3_ENST00000559066.1_Missense_Mutation_p.D457N	NM_006293.3	NP_006284.2	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase	502						integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(26)|ovary(3)|prostate(1)	43		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GGGCATCAGCGATGAACTAAA	0.547000													14	114					0	0	1	0	0
AOC1	26	broad.mit.edu	37	7	150554897	150554897	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr7:150554897G>A	ENST00000493429.1	+	4	1923	c.1339G>A	c.(1339-1341)Ggc>Agc	p.G447S	AOC1_ENST00000467291.1_Missense_Mutation_p.G447S|AOC1_ENST00000416793.2_Missense_Mutation_p.G447S|AOC1_ENST00000360937.4_Missense_Mutation_p.G447S					amine oxidase, copper containing 1																		GGGGCTGAAGGGCCAGGTGCT	0.522000													5	45					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44590377	44590377	+	Missense_Mutation	SNP	A	A	T			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr19:44590377A>T	ENST00000421176.3	+	5	962	c.746A>T	c.(745-747)cAt>cTt	p.H249L	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				ATGTATGTTCATTGCAAATTA	0.418000													5	81					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39799059	39799060	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr1:39799059_39799060insG	ENST00000564288.1	+	37	7576_7577	c.6799_6800insG	c.(6799-6801)ggafs	p.G2267fs	MACF1_ENST00000289893.4_Frame_Shift_Ins_p.G707fs|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000372915.3_Frame_Shift_Ins_p.G2272fs|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000567887.1_Frame_Shift_Ins_p.G2304fs			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2272					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGATAGTGGCAGGGAAATTTTT	0.391													19	93	---	---	---	---					
NR1I3	0	broad.mit.edu	37	1	161202999	161203000	+	Frame_Shift_Ins	INS	-	-	G	rs139473535	by1000genomes	TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr1:161202999_161203000insG	ENST00000367983.4	-	4	661_662	c.367_368insC	c.(367-369)ccafs	p.P123fs	NR1I3_ENST00000511944.1_Intron|NR1I3_ENST00000412844.2_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000508740.1_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000502985.1_Intron|NR1I3_ENST00000508387.1_Intron|NR1I3_ENST00000506209.1_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000367984.4_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000511676.1_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000505005.1_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000504010.1_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000367980.2_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000511748.1_Intron|NR1I3_ENST00000515621.1_Frame_Shift_Ins_p.P48fs|NR1I3_ENST00000442691.2_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000515452.1_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000367985.3_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000367981.3_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000367982.4_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000512372.1_Frame_Shift_Ins_p.P94fs|NR1I3_ENST00000367979.2_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000428574.2_Frame_Shift_Ins_p.P123fs|NR1I3_ENST00000437437.2_Frame_Shift_Ins_p.P94fs			Q14994	NR1I3_HUMAN	nuclear receptor subfamily 1, group I, member 3	123					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	15	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GCCCATGTGGCGGGTGTGGGCC	0.564													7	197	---	---	---	---					
RP11-453E17.1	0	broad.mit.edu	37	4	68632418	68632419	+	RNA	INS	-	-	ACACACACAT	rs59536241	by1000genomes	TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr4:68632418_68632419insACACACACAT	ENST00000500538.2	+	0	1905				RP11-453E17.1_ENST00000502758.1_RNA																							cacacacacacaTATATATAct	0.431													6	7	---	---	---	---					
ATXN1	6310	broad.mit.edu	37	6	16327864	16327865	+	In_Frame_Ins	INS	-	-	TGC			TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr6:16327864_16327865insTGC	ENST00000244769.4	-	8	1613_1614	c.677_678insGCA	c.(676-678)cct>cGCAct	p.226_226P>RT	ATXN1_ENST00000436367.1_In_Frame_Ins_p.226_226P>RT	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	226					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CCCTGCTGAGGtgctgctgctg	0.653													3	6	---	---	---	---					
FOXE1	2304	broad.mit.edu	37	9	100616701	100616706	+	In_Frame_Del	DEL	GCCGCC	GCCGCC	-	rs11279082		TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr9:100616701_100616706delGCCGCC	ENST00000375123.3	+	1	1166_1171	c.505_510delGCCGCC	c.(505-510)del	p.AA177del		NM_004473.3	NP_004464.2	O00358	FOXE1_HUMAN	forkhead box E1 (thyroid transcription factor 2)	177	Ala-rich.|Poly-Ala.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				Ggctgccgcagccgccgccgccgccg	0.767													8	7	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132547093	132547094	+	In_Frame_Ins	INS	-	-	CAG	rs113304321	by1000genomes	TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr12:132547093_132547094insCAG	ENST00000333577.4	+	48	8398_8399	c.8289_8290insCAG	c.(8287-8292)caagca>caCAGagca	p.2763_2763Q>HR	EP400_ENST00000330386.6_In_Frame_Ins_p.2646_2646Q>HR|EP400_ENST00000332482.4_In_Frame_Ins_p.2690_2690Q>HR|EP400_ENST00000389561.2_In_Frame_Ins_p.2727_2727Q>HR|EP400_ENST00000389562.2_In_Frame_Ins_p.2726_2726Q>HR			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagca	0.564													20	39	---	---	---	---					
SLC5A10	125206	broad.mit.edu	37	17	18918510	18918511	+	In_Frame_Ins	INS	-	-	CGGTACGGGGGTGGGGGC	rs71839010		TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chr17:18918510_18918511insCGGTACGGGGGTGGGGGC	ENST00000317977.6	+	10	1609_1610	c.1038_1039insCGGTACGGGGGTGGGGGC	c.(1036-1041)gggcac>ggCGGTACGGGGGTGGGGGCgcac	p.346_347GH>GGTGVGAH	SLC5A10_ENST00000395643.2_In_Frame_Ins_p.386_387GA>GGTGVGAA|SLC5A10_ENST00000395647.2_In_Frame_Ins_p.429_430GA>GGTGVGAA|SLC5A10_ENST00000395642.1_In_Frame_Ins_p.346_347GH>GGTGVGAH|SLC5A10_ENST00000395645.3_In_Frame_Ins_p.413_414GA>GGTGVGAA|SLC5A10_ENST00000417251.2_In_Frame_Ins_p.377_378GA>GGTGVGAA			A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	413					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						TGCTGGTGGGACGGTACGGGGG	0.644													7	18	---	---	---	---					
NUDT11	0	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-DJ-A3V8-01A-11D-A23M-08	TCGA-DJ-A3V8-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	26bcb953-7519-49e7-b082-98d98597c965	1e8f4678-2a06-4cf6-9bc8-722dd7440759	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			7	15	---	---	---	---					
