Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLHL35	283212	broad.mit.edu	37	11	75134897	75134897	+	Missense_Mutation	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr11:75134897G>A	ENST00000539798.1	-	5	1401	c.1402C>T	c.(1402-1404)Cgg>Tgg	p.R468W	KLHL35_ENST00000376292.4_Missense_Mutation_p.R248W	NM_001039548.2	NP_001034637.2	Q6PF15	KLH35_HUMAN	kelch-like family member 35	248										lung(2)|stomach(1)	3						AGGCTCCACCGGTCCTCCTTG	0.612000													3	28					0	0	0.115264	0	0
ATP1B4	23439	broad.mit.edu	37	X	119500552	119500552	+	Missense_Mutation	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chrX:119500552G>A	ENST00000218008.3	+	2	293	c.236G>A	c.(235-237)gGc>gAc	p.G79D	ATP1B4_ENST00000361319.3_Missense_Mutation_p.G79D|ATP1B4_ENST00000539306.1_Missense_Mutation_p.G79D	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	79					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						CAGCCAACAGGCAATGCCTGG	0.527000													42	48					0	0	0.870114	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	95					0	0	0.150653	0	0
FAM13A	10144	broad.mit.edu	37	4	89702434	89702434	+	Missense_Mutation	SNP	T	T	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr4:89702434T>A	ENST00000264344.5	-	11	1547	c.1340A>T	c.(1339-1341)cAg>cTg	p.Q447L	FAM13A_ENST00000395002.2_Missense_Mutation_p.Q121L|FAM13A_ENST00000513837.1_Missense_Mutation_p.Q93L|FAM13A_ENST00000502459.1_5'UTR|FAM13A_ENST00000508369.1_Missense_Mutation_p.Q121L|FAM13A_ENST00000511976.1_Intron|FAM13A_ENST00000503556.1_Missense_Mutation_p.Q107L	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	447					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						TTCGACTTCCTGAGTATTCAA	0.358000													38	78					0	0	0.819951	0	0
DCAF13	25879	broad.mit.edu	37	8	104444914	104444914	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr8:104444914A>G	ENST00000297579.5	+	7	1463	c.1186A>G	c.(1186-1188)Atc>Gtc	p.I396V	DCAF13_ENST00000521999.1_3'UTR	NM_015420.6	NP_056235.4	Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	244					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						AACAAATACAATCTGTTGGAA	0.323000													27	34					0	0	0.804634	0	0
COBL	23242	broad.mit.edu	37	7	51092971	51092971	+	Silent	SNP	C	C	T			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr7:51092971C>T	ENST00000395542.2	-	14	4033	c.3849G>A	c.(3847-3849)ctG>ctA	p.L1283L	COBL_ENST00000265136.7_Silent_p.L1201L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	1201										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CTGGTGGGGACAGAAGACCAA	0.627000													25	48					0	0	0.779181	0	0
MUC4	4585	broad.mit.edu	37	3	195511870	195511870	+	Missense_Mutation	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr3:195511870G>A	ENST00000463781.3	-	2	7040	c.6581C>T	c.(6580-6582)cCt>cTt	p.P2194L	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.P2194L	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	983					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTCGGTGACAGGAAGAGGGGT	0.592000													6	12					0	0	0.335167	0	0
ZNF507	22847	broad.mit.edu	37	19	32844893	32844893	+	Missense_Mutation	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr19:32844893G>A	ENST00000311921.3	+	2	1349	c.1157G>A	c.(1156-1158)aGc>aAc	p.S386N	ZNF507_ENST00000355898.5_Missense_Mutation_p.S386N|ZNF507_ENST00000587084.1_3'UTR|ZNF507_ENST00000544431.1_Missense_Mutation_p.S386N	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					AAAATCATCAGCAGCAGCCCC	0.458000													3	46					0	0	0.115264	0	0
TRHDE	29953	broad.mit.edu	37	12	72667128	72667128	+	Silent	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr12:72667128G>A	ENST00000261180.4	+	1	666	c.570G>A	c.(568-570)gaG>gaA	p.E190E	TRHDE-AS1_ENST00000426250.3_RNA	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	190					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TGGCGGTGGAGAAAGTGCAGC	0.612000													4	105					0	0	0.184627	0	0
OTUD6A	139562	broad.mit.edu	37	X	69283005	69283005	+	Missense_Mutation	SNP	G	G	T			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chrX:69283005G>T	ENST00000338352.2	+	1	665	c.631G>T	c.(631-633)Gtg>Ttg	p.V211L		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	211	OTU.							p.V211M(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						CGACAACATCGTGCGCACCAC	0.612000													37	55					4.16155e-14	4.80178e-14	0.840704	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													3	14					0	0	0.150653	0	0
MARCH1	55016	broad.mit.edu	37	4	164506962	164506962	+	Missense_Mutation	SNP	C	C	T			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr4:164506962C>T	ENST00000503008.1	-	6	1338	c.362G>A	c.(361-363)cGc>cAc	p.R121H	MARCH1_ENST00000274056.7_Missense_Mutation_p.R121H|MARCH1_ENST00000514618.1_Missense_Mutation_p.R377H|MARCH1_ENST00000339875.5_Missense_Mutation_p.R104H	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	121					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CTCACAGCAGCGTGTATCTGA	0.527000													40	118					0	0	0.859065	0	0
FAM76B	143684	broad.mit.edu	37	11	95522617	95522617	+	Missense_Mutation	SNP	C	C	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr11:95522617C>G	ENST00000358780.5	-	1	338	c.26G>C	c.(25-27)tGc>tCc	p.C9S	FAM76B_ENST00000536839.1_Missense_Mutation_p.C9S	NM_144664.4	NP_653265.3	Q5HYJ3	FA76B_HUMAN	family with sequence similarity 76, member B	9										breast(1)|kidney(1)|lung(1)	3		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ACACTTGGTGCAGGCGTACAG	0.711000													5	24					0	0	0.248553	0	0
AC024560.3	0	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	T	C	rs138265355	by1000genomes	TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr3:197348646T>C	ENST00000418868.1	-	0	613					NR_003266.2																						TGGGCCTGCCTGCCCTTTCCA	0.532000													6	107					0	0	0.278610	0	0
KIAA1522	57648	broad.mit.edu	37	1	33233411	33233411	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr1:33233411A>G	ENST00000401073.2	+	2	329	c.259A>G	c.(259-261)Aaa>Gaa	p.K87E	KIAA1522_ENST00000294521.3_Missense_Mutation_p.K28E|KIAA1522_ENST00000373480.1_Missense_Mutation_p.K28E|KIAA1522_ENST00000373481.3_Missense_Mutation_p.K39E	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	28										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TGAGAATGACAAACATCTAAG	0.602000													6	167					0	0	0.335167	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	G	C			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr19:49926533G>C	ENST00000270631.1	-	1	165	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	22					neuropeptide signaling pathway	extracellular region		p.L22V(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.692000													3	39					0	0	0.115264	0	0
NPIPA5	100288332	broad.mit.edu	37	16	15457676	15457676	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr16:15457676A>G	ENST00000360151.4	-	8	892	c.893T>C	c.(892-894)cTa>cCa	p.L298P		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5																		CGCTGAGGGTAGAGCTGAGGG	0.562000													5	241					0	0	0.278610	0	0
DNMT1	1786	broad.mit.edu	37	19	10249155	10249155	+	Missense_Mutation	SNP	C	C	T			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr19:10249155C>T	ENST00000340748.4	-	34	4262	c.4027G>A	c.(4027-4029)Gtg>Atg	p.V1343M	DNMT1_ENST00000540357.1_Missense_Mutation_p.V1343M|DNMT1_ENST00000359526.4_Missense_Mutation_p.V1359M			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	1343	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TCCACCACCACGCTCAGCTGG	0.642000													5	175					0	0	0.217242	0	0
GCC2	9648	broad.mit.edu	37	2	109087511	109087511	+	Missense_Mutation	SNP	A	A	T			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr2:109087511A>T	ENST00000309863.6	+	6	2440	c.1726A>T	c.(1726-1728)Agt>Tgt	p.S576C		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	576					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						ACTTAGTCTCAGTCAAAGAGA	0.289000													14	15					0	0	0.479597	0	0
PALM2	114299	broad.mit.edu	37	9	112705375	112705375	+	Silent	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr9:112705375G>A	ENST00000448454.2	+	8	912	c.912G>A	c.(910-912)ccG>ccA	p.P304P	PALM2_ENST00000374531.2_Silent_p.P270P|AKAP2_ENST00000555236.1_Intron|PALM2-AKAP2_ENST00000302798.7_Intron|AKAP2_ENST00000510514.5_Intron|PALM2_ENST00000483909.1_Silent_p.P268P|PALM2-AKAP2_ENST00000374530.3_Intron|PALM2_ENST00000314527.4_Silent_p.P302P					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						CTGCAGGGCCGGAGGCAAACT	0.502000													3	58					0	0	0.115264	0	0
AMBN	258	broad.mit.edu	37	4	71465351	71465351	+	Missense_Mutation	SNP	T	T	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr4:71465351T>A	ENST00000322937.6	+	5	385	c.282T>A	c.(280-282)caT>caA	p.H94Q	AMBN_ENST00000449493.2_Missense_Mutation_p.H94Q	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	94					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			CAAGAGAACATGAAACTCAAC	0.383000													5	79					0	0	0.184627	0	0
AKT1	207	broad.mit.edu	37	14	105242100	105242100	+	Silent	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr14:105242100G>A	ENST00000554581.1	-	4	1804	c.324C>T	c.(322-324)gaC>gaT	p.D108D	AKT1_ENST00000544168.1_Silent_p.D46D|AKT1_ENST00000554848.1_Silent_p.D108D|AKT1_ENST00000402615.2_Silent_p.D108D|AKT1_ENST00000349310.3_Silent_p.D108D|AKT1_ENST00000555528.1_Silent_p.D108D|AKT1_ENST00000407796.2_Silent_p.D108D			P31749	AKT1_HUMAN	v-akt murine thymoma viral oncogene homolog 1	108	PH.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			NS(3)|breast(97)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(7)|lung(10)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|thyroid(10)|urinary_tract(15)	176		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	TCTTGAGGCCGTCAGCCACAG	0.617000		1	Mis		"""breast, colorectal, ovarian, NSCLC"""								4	117					0	0	0.248553	0	0
ZNF211	0	broad.mit.edu	37	19	58153415	58153415	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr19:58153415A>G	ENST00000544273.1	+	5	1924	c.1597A>G	c.(1597-1599)Agt>Ggt	p.S533G	ZNF211_ENST00000391703.3_Missense_Mutation_p.S460G|ZNF211_ENST00000347302.3_Missense_Mutation_p.S521G|ZNF211_ENST00000420680.1_Missense_Mutation_p.S525G|ZNF211_ENST00000254182.7_Missense_Mutation_p.S512G|ZNF211_ENST00000240731.4_Missense_Mutation_p.S534G|ZNF211_ENST00000541801.1_Missense_Mutation_p.S512G|ZNF211_ENST00000299871.5_Missense_Mutation_p.S586G			Q13398	ZN211_HUMAN	zinc finger protein 211	521						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTTTAGCCAAAGTTCTAGCCT	0.438000													6	156					0	0	0.248553	0	0
MID2	11043	broad.mit.edu	37	X	107167660	107167660	+	Missense_Mutation	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chrX:107167660G>A	ENST00000262843.6	+	8	2071	c.1523G>A	c.(1522-1524)cGc>cAc	p.R508H	MID2_ENST00000443968.2_Missense_Mutation_p.R478H|RP6-191P20.4_ENST00000430140.1_RNA	NM_012216.3|NM_052817.2	NP_036348.2|NP_438112.2	Q9UJV3	TRIM1_HUMAN	midline 2	508	Fibronectin type-III.					centrosome|microtubule	ligase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)	19						AGCGGGACTCGCTACATCTTC	0.458000													6	112					0	0	0.217242	0	0
CDKN1B	1027	broad.mit.edu	37	12	12874031	12874031	+	Missense_Mutation	SNP	T	T	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr12:12874031T>G	ENST00000396340.1	+	2	526	c.508T>G	c.(508-510)Tac>Gac	p.Y170D	CDKN1B_ENST00000477087.1_3'UTR|CDKN1B_ENST00000228872.4_3'UTR			P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			breast(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(5)	13		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		AAGGAAGATATACATGAAAAT	0.318000													4	9					0	0	0.184627	0	0
NSD1	64324	broad.mit.edu	37	5	176636938	176636938	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr5:176636938A>G	ENST00000439151.2	+	5	1583	c.1538A>G	c.(1537-1539)aAg>aGg	p.K513R	NSD1_ENST00000354179.4_Missense_Mutation_p.K244R|NSD1_ENST00000361032.4_Missense_Mutation_p.K410R|NSD1_ENST00000347982.4_Missense_Mutation_p.K244R	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	513					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGTGTGAAAAAGGGCCACATA	0.423000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			3	87					0	0	0.115264	0	0
YME1L1	10730	broad.mit.edu	37	10	27420862	27420862	+	Missense_Mutation	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr10:27420862G>A	ENST00000326799.3	-	9	1103	c.955C>T	c.(955-957)Cgg>Tgg	p.R319W	YME1L1_ENST00000463270.1_5'UTR|YME1L1_ENST00000375972.3_Missense_Mutation_p.R229W|YME1L1_ENST00000376016.3_Missense_Mutation_p.R262W	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	319					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						GTTGTTGTCCGGAAGCGGACT	0.368000													3	85					0	0	0.150653	0	0
HRAS	3265	broad.mit.edu	37	11	533875	533875	+	Missense_Mutation	SNP	G	G	T	rs28933406		TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr11:533875G>T	ENST00000417302.1	-	3	368	c.181C>A	c.(181-183)Cag>Aag	p.Q61K	HRAS_ENST00000311189.7_Missense_Mutation_p.Q61K|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61K|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61K|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61K	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61K(61)|p.Q61R(1)|p.Q61E(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TACTCCTCCTGGCCGGCGGTA	0.597000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			73	118					9.24773e-40	1.09513e-39	0.870114	1	0
CREB3L3	84699	broad.mit.edu	37	19	4157169	4157169	+	Missense_Mutation	SNP	G	G	A	rs145839480	byFrequency	TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr19:4157169G>A	ENST00000078445.2	+	3	481	c.334G>A	c.(334-336)Ggc>Agc	p.G112S	CREB3L3_ENST00000602257.1_Missense_Mutation_p.G112S|CREB3L3_ENST00000602147.1_Missense_Mutation_p.G112S|CREB3L3_ENST00000595923.1_Missense_Mutation_p.G111S|CREB3L3_ENST00000252587.3_Missense_Mutation_p.G102S	NM_001271995.1|NM_001271996.1|NM_032607.1	NP_001258924.1|NP_001258925.1|NP_115996.1	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like 3	112					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|urinary_tract(3)	24				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCCCCGCCGGCTGCCATCC	0.657000													6	124					0	0	0.248553	0	0
KIF6	221458	broad.mit.edu	37	6	39512314	39512314	+	Silent	SNP	C	C	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr6:39512314C>G	ENST00000538893.1	-	12	1467	c.1443G>C	c.(1441-1443)gtG>gtC	p.V481V	KIF6_ENST00000373215.3_Intron|KIF6_ENST00000373216.3_Intron|KIF6_ENST00000373213.4_Intron|KIF6_ENST00000287152.7_Intron			Q6ZMV9	KIF6_HUMAN	kinesin family member 6	481					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GTTTCTTCATCACTTCAGAAA	0.408000													4	49					0	0	0.184627	0	0
ZNF33B	7582	broad.mit.edu	37	10	43089114	43089114	+	Silent	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr10:43089114G>A	ENST00000359467.3	-	5	1398	c.1284C>T	c.(1282-1284)ctC>ctT	p.L428L	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	428						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						GATGTTTAGTGAGGTCAGATT	0.418000													65	96					0	0	0.870114	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212431	26212431	+	Silent	SNP	G	G	T			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chrX:26212431G>T	ENST00000379034.1	+	2	617	c.468G>T	c.(466-468)tcG>tcT	p.S156S		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	156	Ser-rich.							p.S156S(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						CCACTGGCTCGCCTGATGCAG	0.507000													4	76					0.150653	0.165351	0.150653	1	0
ZNF692	55657	broad.mit.edu	37	1	249151529	249151529	+	Missense_Mutation	SNP	T	T	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr1:249151529T>G	ENST00000451251.1	-	4	739	c.394A>C	c.(394-396)Agc>Cgc	p.S132R	ZNF692_ENST00000306601.4_Missense_Mutation_p.S127R|ZNF692_ENST00000366471.3_Missense_Mutation_p.S127R|ZNF692_ENST00000468455.1_5'UTR|ZNF692_ENST00000366469.5_Missense_Mutation_p.S127R|ZNF692_ENST00000427146.1_Missense_Mutation_p.S127R	NM_001136036.2	NP_001129508.1	Q9BU19	ZN692_HUMAN	zinc finger protein 692	127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)	17	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGTGTAGGGCTCAAAGAGGGT	0.637000													54	81					0	0	0.870114	0	0
SPAG17	200162	broad.mit.edu	37	1	118565931	118565931	+	Missense_Mutation	SNP	C	C	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr1:118565931C>G	ENST00000336338.5	-	28	4130	c.4065G>C	c.(4063-4065)aaG>aaC	p.K1355N		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1355						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TGTTACCTTTCTTTGTGTTGG	0.363000													23	25					0	0	0.706142	0	0
NBPF10	100132406	broad.mit.edu	37	1	145327548	145327548	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr1:145327548A>G	ENST00000342960.5	+	32	4140	c.4105A>G	c.(4105-4107)Aat>Gat	p.N1369D	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	1369										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GGACTCACTGAATAGATGTTA	0.473000													2	10					0	0	0.115264	0	0
PDLIM7	9260	broad.mit.edu	37	5	176919616	176919616	+	Silent	SNP	G	G	A			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr5:176919616G>A	ENST00000355841.2	-	3	225	c.159C>T	c.(157-159)atC>atT	p.I53I	PDLIM7_ENST00000359895.2_Silent_p.I53I|PDLIM7_ENST00000356618.4_Silent_p.I53I|PDLIM7_ENST00000355572.2_Silent_p.I53I|PDLIM7_ENST00000393551.1_Silent_p.I53I	NM_005451.3	NP_005442.2	Q9NR12	PDLI7_HUMAN	PDZ and LIM domain 7 (enigma)	53	PDZ.				cell differentiation|multicellular organismal development|ossification|receptor-mediated endocytosis	cytoplasm|focal adhesion	protein binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	10	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTCGCCATCGATGCTCAGCA	0.652000													4	141					0	0	0.217242	0	0
RGPD2	729857	broad.mit.edu	37	2	88125234	88125234	+	Silent	SNP	T	T	C			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr2:88125234T>C	ENST00000398146.3	-	1	237	c.15A>G	c.(13-15)aaA>aaG	p.K5K	RGPD2_ENST00000327544.6_5'UTR|RGPD2_ENST00000420840.2_Intron			Q68DN6	RGPD1_HUMAN	RANBP2-like and GRIP domain containing 2	0					intracellular transport		binding			breast(1)|pancreas(1)	2						CCCCGTAGGCTTTGCTGCGCC	0.667000													4	32					0	0	0.184627	0	0
TMEM52	339456	broad.mit.edu	37	1	1850628	1850636	+	In_Frame_Del	DEL	AGCGGCAGG	AGCGGCAGG	-			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr1:1850628_1850636delAGCGGCAGG	ENST00000310991.3	-	1	76_84	c.69_77delCCTGCCGCT	c.(67-78)ctg>ct	p.LLPL23del		NM_178545.3	NP_848640.1	Q8NDY8	TMM52_HUMAN	transmembrane protein 52	23						integral to membrane				NS(1)|prostate(1)|stomach(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACCTgcggcagcggcaggagcggcagga	0.766													3	4	---	---	---	---					
NEXN	91624	broad.mit.edu	37	1	78390884	78390887	+	Frame_Shift_Del	DEL	AAAC	AAAC	-			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr1:78390884_78390887delAAAC	ENST00000330010.8	+	5	564_567	c.267_270delAAAC	c.(265-270)atfs	p.IN89fs	NEXN_ENST00000457030.1_Intron|NEXN_ENST00000334785.7_Frame_Shift_Del_p.IN153fs	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	153	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		TTGAGGACATAAACAATACGGGAA	0.289													8	142	---	---	---	---					
AC019118.2	0	broad.mit.edu	37	2	2910768	2910769	+	RNA	INS	-	-	T	rs142585959	by1000genomes	TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr2:2910768_2910769insT	ENST00000457478.1	-	0	594																											tccaccccctctcccCAGCCCA	0.698													2	4	---	---	---	---					
RP11-115D19.1	0	broad.mit.edu	37	4	90516654	90516655	+	RNA	DEL	TG	TG	-			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr4:90516654_90516655delTG	ENST00000508021.1	+	0	190				RP11-115D19.1_ENST00000506864.1_RNA|RP11-115D19.1_ENST00000512077.1_RNA|RP11-115D19.1_ENST00000509723.1_RNA																							cgtgtgtgtctgtgtgtgtgtg	0.361													2	4	---	---	---	---					
RP11-238I10.1	0	broad.mit.edu	37	8	111630559	111630560	+	RNA	INS	-	-	A	rs13258806	by1000genomes	TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr8:111630559_111630560insA	ENST00000523264.1	+	0	66																											cctcctcccccactcctctttc	0.510													2	4	---	---	---	---					
PPTC7	160760	broad.mit.edu	37	12	111020740	111020742	+	In_Frame_Del	DEL	CGC	CGC	-			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr12:111020740_111020742delCGC	ENST00000354300.3	-	1	383_385	c.95_97delGCG	c.(94-99)gac>g	p.GD32del		NM_139283.1	NP_644812.1	Q8NI37	PPTC7_HUMAN	PTC7 protein phosphatase homolog (S. cerevisiae)	32	Gly-rich.						metal ion binding|phosphoprotein phosphatase activity			endometrium(1)|large_intestine(2)|lung(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	9						AGTCCGTAGTcgccgccgccgcc	0.739													4	5	---	---	---	---					
ZNF839	55778	broad.mit.edu	37	14	102807889	102807890	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr14:102807889_102807890delGG	ENST00000262236.5	+	8	2170_2171	c.1815_1816delGG	c.(1813-1818)catgfs	p.QV605fs	ZNF839_ENST00000442396.2_Frame_Shift_Del_p.QV719fs|ZNF839_ENST00000420933.2_3'UTR|ZNF839_ENST00000559185.1_Frame_Shift_Del_p.QV603fs|ZNF839_ENST00000558850.1_Frame_Shift_Del_p.QV603fs	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	603						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CCCAGGCACAGGTGGCAGCGTT	0.589													7	11	---	---	---	---					
TMEM62	80021	broad.mit.edu	37	15	43446993	43446995	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr15:43446993_43446995delCAG	ENST00000260403.2	+	9	1425_1427	c.1146_1148delCAG	c.(1144-1149)tat>ta	p.YS382del		NM_024956.3	NP_079232.3	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	382						integral to membrane				breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		CTAGAAACTACAGTAGTGGGACA	0.379													15	29	---	---	---	---					
HERC1	8925	broad.mit.edu	37	15	63901361	63901361	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr15:63901361delG	ENST00000443617.2	-	78	14592	c.14505delC	c.(14503-14505)aafs	p.N4836fs		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4836	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						AGCGGCAGTTGTTGATGGCAT	0.602													20	24	---	---	---	---					
RP11-307C19.2	0	broad.mit.edu	37	15	77868705	77868707	+	RNA	DEL	AGG	AGG	-			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr15:77868705_77868707delAGG	ENST00000561123.1	+	0	577																											ggggaggagaaggaggaggaggg	0.601													2	4	---	---	---	---					
CTD-2544M6.2	0	broad.mit.edu	37	15	98629747	98629749	+	RNA	DEL	GAG	GAG	-			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr15:98629747_98629749delGAG	ENST00000560195.1	-	0	478				CTD-2544M6.1_ENST00000560360.1_lincRNA																							ggaggaggaagaggaggaggagg	0.488													2	4	---	---	---	---					
C16orf71	146562	broad.mit.edu	37	16	4787957	4787968	+	In_Frame_Del	DEL	ACACAGAAGAGT	ACACAGAAGAGT	-			TCGA-E3-A3DZ-01A-11D-A20C-08	TCGA-E3-A3DZ-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6984bfc-843f-455c-8ac6-2a07a54ec978	881caa69-f9c1-409d-aed1-2f1646c6828e	g.chr16:4787957_4787968delACACAGAAGAGT	ENST00000590191.1	+	3	556_567	c.286_297delACACAGAAGAGT	c.(286-297)del	p.TQKS96del	RP11-127I20.7_ENST00000588099.1_RNA|C16orf71_ENST00000299320.5_Intron			Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	92										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						GGTCTGTGGGACACAGAAGAGTATACGCCTGT	0.524													12	35	---	---	---	---					
