Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													3	61					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2222329	2222329	+	Missense_Mutation	SNP	G	G	A			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr19:2222329G>A	ENST00000398665.3	+	24	3197	c.3161G>A	c.(3160-3162)gGc>gAc	p.G1054D		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	1054						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTGGTGCGGGCAGTGCCAAG	0.667000													3	47					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Silent_p.L113L|NBPF10_ENST00000369339.2_Silent_p.L113L	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													4	60					0	0	1	0	0
LILRB5	0	broad.mit.edu	37	19	54754843	54754843	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr19:54754843A>G	ENST00000450632.1	-	13	1869	c.1792T>C	c.(1792-1794)Tcc>Ccc	p.S598P	LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000449561.2_Intron|LILRB5_ENST00000316219.5_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	423					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGGGTGGGGAGGCCTGGGGG	0.607000													5	59					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195410689	195410689	+	RNA	SNP	C	C	T	rs6583275	by1000genomes	TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr3:195410689C>T	ENST00000445430.1	+	0	1886																											CTTTGAGGTGCACTGGAGGAA	0.567000													3	39					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													5	39					0	0	1	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	G	C			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr19:49926533G>C	ENST00000270631.1	-	1	165	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	22					neuropeptide signaling pathway	extracellular region		p.L22V(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.692000													4	59					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													5	51					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													5	43					0	0	1	0	0
ST8SIA2	8128	broad.mit.edu	37	15	92981586	92981586	+	Silent	SNP	G	G	A			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr15:92981586G>A	ENST00000268164.3	+	4	531	c.294G>A	c.(292-294)aaG>aaA	p.K98K	ST8SIA2_ENST00000539113.1_Silent_p.K77K	NM_006011.3	NP_006002.1	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	98					axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(2)|large_intestine(6)|lung(9)|skin(2)|urinary_tract(1)	20	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			TTCACAGGAAGCAGATTTTAA	0.488000													4	208					0	0	1	0	0
GDPD1	284161	broad.mit.edu	37	17	57298002	57298002	+	Missense_Mutation	SNP	C	C	T			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr17:57298002C>T	ENST00000284116.4	+	1	169	c.32C>T	c.(31-33)tCt>tTt	p.S11F	GDPD1_ENST00000581140.1_Missense_Mutation_p.S11F|GDPD1_ENST00000581276.1_Missense_Mutation_p.S11F	NM_182569.3	NP_872375.2	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain containing 1	11					glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(1)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					TACCTTCTCTCTACGCTAGGA	0.532000											OREG0024617	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	115					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													5	44					0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219346911	219346911	+	Missense_Mutation	SNP	A	A	T			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr2:219346911A>T	ENST00000258399.3	-	17	2129	c.1717T>A	c.(1717-1719)Tcg>Acg	p.S573T	USP37_ENST00000475553.1_5'UTR|USP37_ENST00000418019.1_Missense_Mutation_p.S573T|USP37_ENST00000415516.1_Missense_Mutation_p.S501T|USP37_ENST00000454775.1_Missense_Mutation_p.S573T	NM_020935.2	NP_065986.2	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	573					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TTGTTAAGCGAGAGAGCCACA	0.388000													5	143					0	0	1	0	0
GGT3P	0	broad.mit.edu	37	22	18778602	18778602	+	RNA	SNP	G	G	A			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr22:18778602G>A	ENST00000412448.1	-	0	803																											CTTGGCATCCGCGGCCACGGC	0.627000													3	19					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128671	45128671	+	RNA	SNP	T	T	G	rs1056072	by1000genomes	TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr17:45128671T>G	ENST00000575173.1	-	0	418																											GCTCACAAAATAAGTTCCAGG	0.323000													3	79					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162462	90162462	+	RNA	SNP	A	A	G			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr16:90162462A>G	ENST00000567960.1	+	0	1198				TUBB8P7_ENST00000564451.1_RNA														p.T398T(1)									ACTGGTACACAGGCGAGGGCA	0.522000													3	158					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18846025	18846025	+	RNA	SNP	G	G	C	rs5993363		TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr22:18846025G>C	ENST00000412938.1	+	0	3383																											GACGTTGAAGGCTGCCTTCAG	0.647000													3	143					0	0	1	0	0
OR3A3	8392	broad.mit.edu	37	17	3324703	3324703	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr17:3324703A>G	ENST00000291231.1	+	1	842	c.842A>G	c.(841-843)aAg>aGg	p.K281R		NM_012373.2	NP_036505.2	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A, member 3	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)	9						GACAAGGATAAGGGGGTTGGG	0.507000													3	193					0	0	1	0	0
TSIX	0	broad.mit.edu	37	X	73043035	73043035	+	RNA	SNP	T	T	C			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chrX:73043035T>C	ENST00000604411.1	+	0	30996				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						CCCTGAGCCCTTTTATCAGTC	0.333000													2	6					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128685	45128685	+	RNA	SNP	T	T	C	rs145089594	by1000genomes	TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr17:45128685T>C	ENST00000575173.1	-	0	418																											TTCCAGGATATGGCTATACTG	0.303000													4	84					0	0	1	0	0
AKIRIN2	55122	broad.mit.edu	37	6	88385612	88385612	+	Silent	SNP	T	T	C			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr6:88385612T>C	ENST00000257787.5	-	4	1091	c.567A>G	c.(565-567)caA>caG	p.Q189Q		NM_018064.3	NP_060534.1	Q53H80	AKIR2_HUMAN	akirin 2	189					innate immune response|transcription, DNA-dependent	transcriptional repressor complex				large_intestine(4)	4						GTCGCATTATTTGATCATGCG	0.323000													3	67					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				25	59					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145327548	145327548	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr1:145327548A>G	ENST00000342960.5	+	32	4140	c.4105A>G	c.(4105-4107)Aat>Gat	p.N1369D	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	1369										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GGACTCACTGAATAGATGTTA	0.473000													3	69					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35396935	35396935	+	Splice_Site	SNP	G	G	A			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr9:35396935G>A	ENST00000378495.3	+	27	3507		c.e27+1		UNC13B_ENST00000378496.4_Splice_Site|UNC13B_ENST00000481299.1_Splice_Site|UNC13B_ENST00000396787.1_Splice_Site	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)						excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GAAGGATGGAGTAAGTCAGGG	0.552000													4	171					0	0	1	0	0
AC007092.1	0	broad.mit.edu	37	2	58655794	58655796	+	RNA	DEL	TGC	TGC	-	rs10589511		TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr2:58655794_58655796delTGC	ENST00000452840.1	+	0	127																											TCTGTTCGTTtgctgctgctgct	0.700													2	4	---	---	---	---					
GBA3	57733	broad.mit.edu	37	4	22729654	22729655	+	RNA	INS	-	-	T			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr4:22729654_22729655insT	ENST00000508166.1	+	0	160				GBA3_ENST00000511446.1_RNA|GBA3_ENST00000503442.1_RNA	NM_020973.4	NP_066024.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GTTCCCCTGAGTTTTTTTTTCT	0.342													2	4	---	---	---	---					
HLA-DRB6	0	broad.mit.edu	37	6	32522756	32522756	+	RNA	DEL	A	A	-			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr6:32522756delA	ENST00000411500.1	-	0	458					NR_001298.1																						GGACTAGGAGAAAAAAAGGTA	0.517													8	29	---	---	---	---					
C6orf89	221477	broad.mit.edu	37	6	36867371	36867371	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr6:36867371delC	ENST00000480824.2	+	3	445	c.151delC	c.(151-153)ccfs	p.P53fs	C6orf89_ENST00000359359.2_5'UTR|C6orf89_ENST00000373685.1_Frame_Shift_Del_p.P53fs|C6orf89_ENST00000510325.2_5'UTR|C6orf89_ENST00000355190.3_Frame_Shift_Del_p.P60fs			Q6UWU4	CF089_HUMAN	chromosome 6 open reading frame 89	53						integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	15						ACCTCAGAGACCCCCCCCGCA	0.428													7	114	---	---	---	---					
GDF6	392255	broad.mit.edu	37	8	97157245	97157245	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr8:97157245delG	ENST00000287020.5	-	2	1013	c.914delC	c.(913-915)cgfs	p.P305fs		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	305					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					gcccgcgcccgggcccgcAGC	0.776													2	4	---	---	---	---					
TXNRD1	7296	broad.mit.edu	37	12	104651840	104651840	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr12:104651840delT	ENST00000525566.1	+	3	311	c.287delT	c.(286-288)ctfs	p.L96fs	TXNRD1_ENST00000526006.1_3'UTR|TXNRD1_ENST00000429002.2_Frame_Shift_Del_p.L96fs	NM_001093771.2	NP_001087240.1	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	96	Glutaredoxin.				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						TATTTTGTGCTTGAACTTGAT	0.308													2	4	---	---	---	---					
CHD3	1107	broad.mit.edu	37	17	7788212	7788214	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr17:7788212_7788214delGAG	ENST00000380358.4	+	1	89_91	c.88_90delGAG	c.(88-90)del	p.E35del	LSMD1_ENST00000576861.1_Intron|LSMD1_ENST00000570555.1_Intron	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	450					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				agagggcgacgaggaggaggagg	0.685													4	6	---	---	---	---					
ISYNA1	51477	broad.mit.edu	37	19	18547527	18547528	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr19:18547527_18547528delCG	ENST00000545187.1	-	2	411_412	c.125_126delCG	c.(124-126)gfs	p.A42fs	ISYNA1_ENST00000317018.6_Intron|ISYNA1_ENST00000578963.1_Frame_Shift_Del_p.A64fs|ISYNA1_ENST00000338128.7_Frame_Shift_Del_p.A192fs|ISYNA1_ENST00000457269.3_Frame_Shift_Del_p.A138fs			Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	192					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			breast(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	12						TGAGGTTGTCCGCGCGCGCGCT	0.644													3	4	---	---	---	---					
POM121L9P	0	broad.mit.edu	37	22	24656046	24656046	+	RNA	DEL	G	G	-			TCGA-E3-A3E2-01A-11D-A20C-08	TCGA-E3-A3E2-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7adbf25b-0508-4625-9781-8fd3d054814e	6783d5e4-0cf6-4fdf-af00-edcb75c87770	g.chr22:24656046delG	ENST00000414583.2	+	0	1948					NR_003714.1																						AGCTGCTGGTGGGGAGGTCTT	0.637													4	8	---	---	---	---					
