Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FBXO47	494188	broad.mit.edu	37	17	37101328	37101328	+	Missense_Mutation	SNP	A	A	C			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr17:37101328A>C	ENST00000378079.2	-	7	877	c.678T>G	c.(676-678)caT>caG	p.H226Q		NM_001008777.2	NP_001008777.2	Q5MNV8	FBX47_HUMAN	F-box protein 47	226										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	20						GATGTGTCCAATGATCAAGGA	0.388000													28	45					0	0	0.760397	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6180	6180	+	Missense_Mutation	SNP	G	G	C			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chrM:6180G>C	ENST00000361624.2	+	1	277	c.277G>C	c.(277-279)Gcg>Ccg	p.93_93insP						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						CCCCCGATATGGCGTTTCCCC	0.483000													10	345					0	0	0.500413	0	0
NFATC4	4776	broad.mit.edu	37	14	24845682	24845682	+	Missense_Mutation	SNP	C	C	G			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr14:24845682C>G	ENST00000413692.2	+	10	2572	c.2428C>G	c.(2428-2430)Cct>Gct	p.P810A	NFATC4_ENST00000556759.1_Missense_Mutation_p.P282A|NFATC4_ENST00000556279.1_Missense_Mutation_p.P779A|NFATC4_ENST00000556169.1_Missense_Mutation_p.P735A|NFATC4_ENST00000553708.1_Missense_Mutation_p.P747A|NFATC4_ENST00000555802.1_Missense_Mutation_p.P35A|NFATC4_ENST00000553879.1_Missense_Mutation_p.P677A|NFATC4_ENST00000555590.1_Missense_Mutation_p.P760A|NFATC4_ENST00000553469.1_Missense_Mutation_p.P779A|NFATC4_ENST00000557451.1_Missense_Mutation_p.P677A|NFATC4_ENST00000555453.1_Missense_Mutation_p.P735A|NFATC4_ENST00000554050.1_Missense_Mutation_p.P747A|NFATC4_ENST00000554966.1_Missense_Mutation_p.P760A|NFATC4_ENST00000539237.2_Missense_Mutation_p.P779A|NFATC4_ENST00000557767.1_Missense_Mutation_p.P35A|NFATC4_ENST00000554473.1_Missense_Mutation_p.P282A|NFATC4_ENST00000422617.3_Missense_Mutation_p.P735A|NFATC4_ENST00000555393.1_Missense_Mutation_p.P35A|NFATC4_ENST00000554591.1_Missense_Mutation_p.P810A|NFATC4_ENST00000250373.4_Missense_Mutation_p.P747A|NFATC4_ENST00000554661.1_Missense_Mutation_p.P677A|NFATC4_ENST00000554344.1_Missense_Mutation_p.P677A|NFATC4_ENST00000555167.1_Missense_Mutation_p.P282A|NFATC4_ENST00000424781.2_Missense_Mutation_p.P760A	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	747	Pro-rich.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		TGGCATGCCCCCTCTGTACCC	0.617000													16	33					0	0	0.624587	0	0
MCM9	254394	broad.mit.edu	37	6	119245206	119245206	+	Missense_Mutation	SNP	T	T	A			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr6:119245206T>A	ENST00000316316.6	-	3	677	c.391A>T	c.(391-393)Att>Ttt	p.I131F	MCM9_ENST00000316068.3_Missense_Mutation_p.I131F	NM_017696.2	NP_060166.2	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	131					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		CTTGTTCGAATCACTGTCCCA	0.448000													6	285					0	0	0.307466	0	0
NBPF10	100132406	broad.mit.edu	37	1	145293269	145293269	+	Splice_Site	SNP	G	G	A	rs61350760	by1000genomes	TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr1:145293269G>A	ENST00000369338.1	+	1	155		c.e1+1		NBPF10_ENST00000369339.2_Intron|RP11-458D21.5_ENST00000468030.1_Splice_Site			A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10											NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTTCACAACAGTAAGTTAAGA	0.423000													5	34					0	0	0.217242	0	0
SH2D6	284948	broad.mit.edu	37	2	85663670	85663670	+	Missense_Mutation	SNP	G	G	C			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr2:85663670G>C	ENST00000389938.2	+	20	1711	c.397G>C	c.(397-399)Gaa>Caa	p.E133Q	SH2D6_ENST00000481426.2_3'UTR|SH2D6_ENST00000340326.2_Missense_Mutation_p.E165Q			Q7Z4S9	SH2D6_HUMAN	SH2 domain containing 6	165	SH2.									central_nervous_system(1)|lung(2)	3						CGGCAGCCGGGAACTCACCTG	0.647000													14	61					0	0	0.539581	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				24	40					0	0	0.729181	0	0
COL5A3	50509	broad.mit.edu	37	19	10114384	10114384	+	Missense_Mutation	SNP	G	G	C			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr19:10114384G>C	ENST00000264828.3	-	6	791	c.706C>G	c.(706-708)Cag>Gag	p.Q236E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	236	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGTTCACCCTGGGGAGCCTGG	0.607000													4	42					0	0	0.217242	0	0
STXBP5L	9515	broad.mit.edu	37	3	120941872	120941872	+	Missense_Mutation	SNP	G	G	C			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr3:120941872G>C	ENST00000273666.6	+	11	1250	c.979G>C	c.(979-981)Ggt>Cgt	p.G327R	STXBP5L_ENST00000492541.1_Missense_Mutation_p.G327R|STXBP5L_ENST00000497029.1_Missense_Mutation_p.G327R|STXBP5L_ENST00000472879.1_Missense_Mutation_p.G327R|STXBP5L_ENST00000471454.1_Missense_Mutation_p.G327R	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	327					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		AATATTCTCTGGTGGGCTGTC	0.363000													7	84					0	0	0.361761	0	0
AQP12B	653437	broad.mit.edu	37	2	241621918	241621918	+	Silent	SNP	G	G	A			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr2:241621918G>A	ENST00000407834.3	-	1	399	c.337C>T	c.(337-339)Ctg>Ttg	p.L113L		NM_001102467.1	NP_001095937.1	A6NM10	AQ12B_HUMAN	aquaporin 12B	101						integral to membrane	transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|lung(8)|ovary(1)	13		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		GCCAGCTTCAGCAGCGTGCCA	0.697000													4	39					0	0	0.150653	0	0
MT-CYB	4519	broad.mit.edu	37	MT	15170	15170	+	Missense_Mutation	SNP	G	G	A			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chrM:15170G>A	ENST00000361789.2	+	1	424	c.424G>A	c.(424-426)Ggg>Agg	p.142_142insR						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						TATCATTCTGAGGGGCCACAG	0.473000											OREG0007583	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	108	654					0	0	0.870114	0	0
CSMD2	114784	broad.mit.edu	37	1	34037304	34037304	+	Silent	SNP	A	A	G			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr1:34037304A>G	ENST00000373381.4	-	51	7961	c.7785T>C	c.(7783-7785)agT>agC	p.S2595S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2597	Sushi 16.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CGCTGATGCTACTGACATCAG	0.473000													18	45					0	0	0.624587	0	0
KDM6A	7403	broad.mit.edu	37	X	44929202	44929202	+	Missense_Mutation	SNP	A	A	G			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chrX:44929202A>G	ENST00000377967.4	+	17	2343	c.2302A>G	c.(2302-2304)Aag>Gag	p.K768E	KDM6A_ENST00000382899.4_Missense_Mutation_p.K775E|KDM6A_ENST00000543216.1_Missense_Mutation_p.K689E|KDM6A_ENST00000536777.1_Missense_Mutation_p.K723E	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	768					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TGGAGATTCTAAGTCACCAGG	0.473000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								26	21					0	0	0.750413	0	0
CCDC15	80071	broad.mit.edu	37	11	124857495	124857495	+	Missense_Mutation	SNP	A	A	C	rs113451248		TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr11:124857495A>C	ENST00000529051.1	+	8	1632	c.1373A>C	c.(1372-1374)cAc>cCc	p.H458P	CCDC15_ENST00000344762.5_Missense_Mutation_p.H458P			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	458						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CATGTTCTCCACAAAGACCAA	0.418000													3	54					0	0	0.115264	0	0
PHKA2	5256	broad.mit.edu	37	X	18969292	18969292	+	Missense_Mutation	SNP	G	G	T			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chrX:18969292G>T	ENST00000379942.4	-	4	1049	c.384C>A	c.(382-384)gaC>gaA	p.D128E		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	128					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					GGCCCCACTGGTCGTCGCCCA	0.607000													5	83					0.00116845	0.00129827	0.217242	1	0
RP11-262H14.1	0	broad.mit.edu	37	9	66457980	66457980	+	RNA	SNP	A	A	G			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr9:66457980A>G	ENST00000424345.1	+	0	67																											GCGAGTCGGAAGAGGTGGGAT	0.726000													3	10					0	0	0.184627	0	0
OVCH2	341277	broad.mit.edu	37	11	7716913	7716913	+	RNA	SNP	T	T	A			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr11:7716913T>A	ENST00000454689.1	-	0	1171				OVCH2_ENST00000534193.1_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		TAAGAATGGATGAggccgggc	0.517000													3	5					0	0	0.115264	0	0
MT-ND6	4541	broad.mit.edu	37	MT	14249	14249	+	Missense_Mutation	SNP	G	G	A			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chrM:14249G>A	ENST00000361681.2	-	1	424	c.425C>T	c.(424-426)gCg>gTg	p.A142V						mitochondrially encoded NADH dehydrogenase 6											breast(1)|endometrium(10)|kidney(17)|urinary_tract(1)	29						ACAAAGCCCCCGCACCAATAG	0.428000													19	457					0	0	0.681144	0	0
MYH6	4624	broad.mit.edu	37	14	23866789	23866789	+	Missense_Mutation	SNP	T	T	C			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr14:23866789T>C	ENST00000405093.3	-	16	1995	c.1925A>G	c.(1924-1926)aAg>aGg	p.K642R	MYH6_ENST00000356287.3_Missense_Mutation_p.K642R	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	642	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GGATGAGCCCTTTTTCTTGCC	0.557000													3	44					0	0	0.150653	0	0
FOXR2	139628	broad.mit.edu	37	X	55650462	55650462	+	Silent	SNP	C	C	T			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chrX:55650462C>T	ENST00000339140.3	+	1	630	c.318C>T	c.(316-318)aaC>aaT	p.N106N		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	106					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						ATCTGACAAACATTTCTCCTT	0.542000													9	13					0	0	0.307466	0	0
MT-RNR2	0	broad.mit.edu	37	MT	3132	3132	+	RNA	SNP	G	G	A			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chrM:3132G>A	ENST00000387347.2	+	0	1462					NR_039705.1																						CTGTACGAAAGGACAAGAGAA	0.438000													349	75					0	0	0.870114	0	0
ZNF860	344787	broad.mit.edu	37	3	32032046	32032046	+	Missense_Mutation	SNP	G	G	A	rs143925165	by1000genomes	TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr3:32032046G>A	ENST00000360311.4	+	2	2024	c.1475G>A	c.(1474-1476)cGt>cAt	p.R492H		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	492					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						AAGACCTTCCGTCACAATTCA	0.403000													4	103					0	0	0.248553	0	0
RP5-1180C18.1	0	broad.mit.edu	37	1	37772032	37772033	+	RNA	DEL	GA	GA	-			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr1:37772032_37772033delGA	ENST00000413901.1	-	0	111																											GGCCCAGAGTGAGAGAGAGGAG	0.525													2	4	---	---	---	---					
NFXL1	152518	broad.mit.edu	37	4	47916171	47916171	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr4:47916171delC	ENST00000507489.1	-	2	226	c.50delG	c.(49-51)gafs	p.G17fs	NFXL1_ENST00000329043.3_Frame_Shift_Del_p.G17fs|NFXL1_ENST00000381538.3_Frame_Shift_Del_p.G17fs	NM_001278624.1	NP_001265553.1	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like 1	17						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(4)	27						AGTGGCCCGTCCCCGGGATCG	0.647													2	4	---	---	---	---					
SP4	6671	broad.mit.edu	37	7	21468304	21468306	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr7:21468304_21468306delAGG	ENST00000222584.3	+	2	235_237	c.17_19delAGG	c.(16-21)aag>a	p.KE6del		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	6					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						GATCAGAAGAAGGAGGAGGAGGA	0.517													2	4	---	---	---	---					
DLX6	1750	broad.mit.edu	37	7	96635421	96635423	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr7:96635421_96635423delGCC	ENST00000518156.2	+	1	562_564	c.132_134delGCC	c.(130-135)cag>ca	p.QP44del	DLX6-AS1_ENST00000458352.2_RNA|DLX6_ENST00000007660.5_Intron|DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6-AS1_ENST00000605417.1_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000437541.1_RNA|DLX6-AS1_ENST00000430027.2_RNA			P56179	DLX6_HUMAN	distal-less homeobox 6	0					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					aacagcaacagccgccgccgccg	0.704													3	4	---	---	---	---					
RP11-897M7.1	0	broad.mit.edu	37	12	131962224	131962225	+	RNA	INS	-	-	ATA	rs67902503		TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr12:131962224_131962225insATA	ENST00000535133.1	-	0	195																											tggtaatggtggtgatgatggt	0.396													6	9	---	---	---	---					
RP11-519G16.3	0	broad.mit.edu	37	15	45756158	45756158	+	RNA	DEL	T	T	-	rs143709087		TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr15:45756158delT	ENST00000560077.1	+	0	41				RP11-519G16.3_ENST00000558536.1_RNA|RP11-519G16.3_ENST00000560647.1_RNA																							accaccaccatcaccatcacc	0.567													4	6	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93552546	93552547	+	Frame_Shift_Ins	INS	-	-	G			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr15:93552546_93552547insG	ENST00000394196.4	+	35	5653_5654	c.4585_4586insG	c.(4585-4587)gagfs	p.E1529fs	CHD2_ENST00000557381.1_Frame_Shift_Ins_p.E1529fs	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1529					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CATCAAACTCTGGAGGAGGTAA	0.495													19	40	---	---	---	---					
CAPN15	6650	broad.mit.edu	37	16	597239	597241	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr16:597239_597241delAGG	ENST00000219611.2	+	4	764_766	c.401_403delAGG	c.(400-405)cag>c	p.QE134del	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		aaggaggagcaggaggaggagga	0.714													2	4	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													2	4	---	---	---	---					
PANX2	56666	broad.mit.edu	37	22	50616616	50616617	+	Frame_Shift_Ins	INS	-	-	C			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chr22:50616616_50616617insC	ENST00000395842.2	+	2	1475_1476	c.1475_1476insC	c.(1474-1476)gccfs	p.A492fs	PANX2_ENST00000159647.5_Frame_Shift_Ins_p.A492fs	NM_052839.3	NP_443071.2	Q96RD6	PANX2_HUMAN	pannexin 2	492					protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)	7		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		GGCGACCCGGGccccggccccg	0.748													4	3	---	---	---	---					
RP11-308D16.4	0	broad.mit.edu	37	X	135999124	135999129	+	RNA	DEL	TCTTCT	TCTTCT	-			TCGA-E3-A3E3-01A-11D-A20C-08	TCGA-E3-A3E3-10A-01D-A20C-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	42777e66-8bee-408a-b462-e72f09904209	0e05f7f5-f01b-479b-9dde-821a7ed463dd	g.chrX:135999124_135999129delTCTTCT	ENST00000424306.1	+	0	386																											ctcctcttcctcttcttcctcttcct	0.505													4	4	---	---	---	---					
