Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WBSCR28	135886	broad.mit.edu	37	7	73279335	73279335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr7:73279335C>T	ENST00000320531.2	+	2	121	c.85C>T	c.(85-87)Cga>Tga	p.R29*		NM_182504.3	NP_872310.2	Q6UE05	WBS28_HUMAN	Williams-Beuren syndrome chromosome region 28	29						integral to membrane		p.R29I(1)		breast(2)|kidney(2)|lung(6)|skin(1)	11		Lung NSC(55;0.159)				GGTTCAGAACCGAGATCACCT	0.507000													114	560					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127796843	127796843	+	Silent	SNP	G	G	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr6:127796843G>A	ENST00000556132.1	-	6	3192	c.2328C>T	c.(2326-2328)ccC>ccT	p.P776P	SOGA3_ENST00000525778.1_Silent_p.P776P|SOGA3_ENST00000481848.2_Silent_p.P776P|SOGA3_ENST00000368268.2_Silent_p.P776P|SOGA3_ENST00000465909.2_Silent_p.P776P	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	776						integral to membrane											CGCCGCCGATGGGCCCTTCGC	0.726000													24	50					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37485776	37485776	+	Silent	SNP	C	C	T			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr22:37485776C>T	ENST00000381792.2	-	7	818	c.678G>A	c.(676-678)ctG>ctA	p.L226L	TMPRSS6_ENST00000406725.1_Silent_p.L226L|TMPRSS6_ENST00000406856.1_Silent_p.L226L|TMPRSS6_ENST00000346753.3_Silent_p.L235L|TMPRSS6_ENST00000442782.2_Silent_p.L235L			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	235	CUB 1.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						CAGGCCCCTTCAGCCGGAGGA	0.667000													4	12					0	0	1	0	0
PDE7B	27115	broad.mit.edu	37	6	136508198	136508198	+	Missense_Mutation	SNP	T	T	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr6:136508198T>A	ENST00000308191.6	+	12	1373	c.1070T>A	c.(1069-1071)cTg>cAg	p.L357Q	RP13-143G15.4_ENST00000591521.1_RNA|RP13-143G15.4_ENST00000585946.1_RNA|RP13-143G15.4_ENST00000417643.1_RNA	NM_018945.3	NP_061818.1	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	357	Catalytic (By similarity).				signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	AAATTTGAACTGGAAATCAGT	0.294000													14	40					0	0	1	0	0
NPBWR1	2831	broad.mit.edu	37	8	53852926	53852926	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr8:53852926C>A	ENST00000331251.3	+	1	1936	c.459C>A	c.(457-459)agC>agA	p.S153R		NM_005285.3	NP_005276.2	P48145	NPBW1_HUMAN	neuropeptides B/W receptor 1	153					synaptic transmission	plasma membrane	opioid receptor activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)	17		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				GCACCTACAGCGCCGCGCGCG	0.711000													4	19					0.150653	0.150653	1	1	0
AKAP17A	8227	broad.mit.edu	37	X	1714353	1714353	+	Missense_Mutation	SNP	A	A	C			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chrX:1714353A>C	ENST00000313871.3	+	3	1035	c.839A>C	c.(838-840)gAa>gCa	p.E280A	AKAP17A_ENST00000381261.3_Missense_Mutation_p.E280A	NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	280					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						AAGCTTCAGGAACTGGAGCAG	0.527000													54	148					0	0	1	0	0
SCARF1	8578	broad.mit.edu	37	17	1538386	1538386	+	Missense_Mutation	SNP	G	G	A	rs144425748	byFrequency	TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr17:1538386G>A	ENST00000263071.4	-	11	2208	c.2159C>T	c.(2158-2160)gCg>gTg	p.A720V	SCARF1_ENST00000571272.1_3'UTR|SCARF1_ENST00000348987.3_Missense_Mutation_p.A634V	NM_003693.2|NM_145350.1	NP_003684.2|NP_663325.1	Q14162	SREC_HUMAN	scavenger receptor class F, member 1	720	Gly-rich.				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity	p.A720E(1)		cervix(1)|endometrium(3)|kidney(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CTTGGCTTCCGCCTGGCCTTT	0.632000													5	34					0	0	1	0	0
ZNF286B	729288	broad.mit.edu	37	17	18565373	18565373	+	Silent	SNP	A	A	G	rs147985634	by1000genomes	TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr17:18565373A>G	ENST00000545289.1	-	5	1696	c.1446T>C	c.(1444-1446)ctT>ctC	p.L482L		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	482					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						GATGTTGAATAAGAGCTGATG	0.388000													4	34					0	0	1	0	0
THAP10	56906	broad.mit.edu	37	15	71184271	71184271	+	Missense_Mutation	SNP	T	T	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr15:71184271T>A	ENST00000249861.4	-	1	853	c.341A>T	c.(340-342)gAg>gTg	p.E114V	LRRC49_ENST00000544974.2_Intron	NM_020147.3	NP_064532.1	Q9P2Z0	THA10_HUMAN	THAP domain containing 10	114							DNA binding|metal ion binding			NS(1)|kidney(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						TGCCTGGAGCTCTCCTCGCGT	0.682000													13	10					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328887	80328887	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr4:80328887C>A	ENST00000358842.3	-	1	485	c.468G>T	c.(466-468)tgG>tgT	p.W156C		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	156					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						TGTCAAGCATCCAACGAAGTT	0.413000													20	98					1.56452e-12	1.84062e-12	1	1	0
SETD1A	9739	broad.mit.edu	37	16	30970090	30970090	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr16:30970090C>G	ENST00000262519.8	+	2	724	c.38C>G	c.(37-39)cCg>cGg	p.P13R		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	13					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						CAGAAGGCCCCGAGCTTCCAG	0.577000													19	84					0	0	1	0	0
DNAJC8	22826	broad.mit.edu	37	1	28559481	28559481	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr1:28559481G>A	ENST00000263697.4	-	1	55	c.29C>T	c.(28-30)tCa>tTa	p.S10L	DNAJC8_ENST00000489277.1_5'UTR	NM_014280.2	NP_055095.2	O75937	DNJC8_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 8	10					nuclear mRNA splicing, via spliceosome|protein folding	nucleoplasm	heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(3)|lung(2)	6		Colorectal(325;3.46e-05)|Lung NSC(340;4.08e-05)|all_lung(284;4.29e-05)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.0105)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		OV - Ovarian serous cystadenocarcinoma(117;2.81e-22)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00275)|BRCA - Breast invasive adenocarcinoma(304;0.0059)|STAD - Stomach adenocarcinoma(196;0.00671)|READ - Rectum adenocarcinoma(331;0.0649)		TCCGCCGCCTGAAGTCCCGCT	0.627000													8	46					0	0	1	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56733610	56733610	+	Silent	SNP	G	G	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr19:56733610G>A	ENST00000587340.1	-	7	1520	c.825C>T	c.(823-825)tgC>tgT	p.C275C	ZSCAN5A_ENST00000587492.1_Silent_p.C129C|ZSCAN5A_ENST00000592355.1_Silent_p.C274C|ZSCAN5A_ENST00000254165.3_Silent_p.C158C|ZSCAN5A_ENST00000391713.1_Silent_p.C275C			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	275					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TCTCCACAACGCAGGCAGAAG	0.527000													20	101					0	0	1	0	0
ZNF654	55279	broad.mit.edu	37	3	88188456	88188456	+	Translation_Start_Site	SNP	G	G	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr3:88188456G>A	ENST00000309495.5	+	0	203				CGGBP1_ENST00000462901.1_Intron	NM_018293.2	NP_060763.2	Q8IZM8	ZN654_HUMAN	zinc finger protein 654						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(1)|ovary(2)|pancreas(1)|prostate(3)	12		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		CCAAGGCATCGTTGTATGTTA	0.398000													5	14					0	0	1	0	0
RALYL	138046	broad.mit.edu	37	8	85097248	85097248	+	Splice_Site	SNP	C	C	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr8:85097248C>A	ENST00000517638.1	+	1	139	c.16_splice	c.e1+1	p.R5_splice	RALYL_ENST00000522455.1_Intron|RALYL_ENST00000521695.1_Intron|RALYL_ENST00000518566.1_Intron|RALYL_ENST00000521268.1_Intron	NM_001100391.1	NP_001093861.1	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	0							identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						GTAAACGACGCAGTAGGTCCT	0.522000													20	35					3.51602e-12	4.05694e-12	1	1	0
NBAS	51594	broad.mit.edu	37	2	15307443	15307443	+	Missense_Mutation	SNP	T	T	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr2:15307443T>A	ENST00000281513.5	-	52	6870	c.6845A>T	c.(6844-6846)aAt>aTt	p.N2282I	NBAS_ENST00000441750.1_Missense_Mutation_p.N2162I	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	2282										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						ATTGGAATCATTCACCTTCAA	0.517000													8	37					0	0	1	0	0
SLC39A8	64116	broad.mit.edu	37	4	103189158	103189158	+	Missense_Mutation	SNP	T	T	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr4:103189158T>A	ENST00000424970.2	-	7	1234	c.919A>T	c.(919-921)Ata>Tta	p.I307L	SLC39A8_ENST00000394833.2_Missense_Mutation_p.I307L|SLC39A8_ENST00000356736.4_Missense_Mutation_p.I307L	NM_001135147.1	NP_001128619.1	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter), member 8	307						integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity			large_intestine(1)|lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		CAGAGCGTTATCATCCAGGCA	0.468000													30	56					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146350748	146350748	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr6:146350748C>T	ENST00000392299.2	+	2	565	c.95C>T	c.(94-96)gCg>gTg	p.A32V	GRM1_ENST00000282753.1_Missense_Mutation_p.A32V|GRM1_ENST00000355289.4_Missense_Mutation_p.A32V|GRM1_ENST00000507907.1_Missense_Mutation_p.A32V|GRM1_ENST00000492807.2_Missense_Mutation_p.A32V|GRM1_ENST00000361719.2_Missense_Mutation_p.A32V			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	32					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CTGGCAGGAGCGTCGTCTCAG	0.582000													59	99					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99827594	99827594	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr11:99827594C>T	ENST00000524871.1	+	8	1020	c.730C>T	c.(730-732)Cgg>Tgg	p.R244W	CNTN5_ENST00000527185.1_Missense_Mutation_p.R244W|CNTN5_ENST00000279463.3_Missense_Mutation_p.R244W|CNTN5_ENST00000418526.2_Missense_Mutation_p.R170W|CNTN5_ENST00000528682.1_Missense_Mutation_p.R244W	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	244	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GGAAGACAGCCGGCGGTTCAT	0.403000													12	33					0	0	1	0	0
ATAD3C	219293	broad.mit.edu	37	1	1390875	1390875	+	Silent	SNP	C	C	T	rs1781147	by1000genomes	TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr1:1390875C>T	ENST00000378785.2	+	5	1409	c.414C>T	c.(412-414)gaC>gaT	p.D138D		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	138							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GACCCCAGGACGTGCTGGAGG	0.677000													6	29					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11319762	11319762	+	Missense_Mutation	SNP	T	T	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr19:11319762T>A	ENST00000294618.7	-	38	4780	c.4769A>T	c.(4768-4770)cAg>cTg	p.Q1590L	CTC-510F12.2_ENST00000588634.1_RNA|DOCK6_ENST00000319867.7_Missense_Mutation_p.Q929L	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1590	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CGGTGAGCCCTGGTAGCCCCG	0.657000													9	7					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29737521	29737521	+	Missense_Mutation	SNP	C	C	T	rs149960917	byFrequency	TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr22:29737521C>T	ENST00000357586.2	-	13	1951	c.1765G>A	c.(1765-1767)Gtg>Atg	p.V589M	AP1B1_ENST00000317368.7_Missense_Mutation_p.V589M|AP1B1_ENST00000432560.2_Missense_Mutation_p.V589M|AP1B1_ENST00000356015.2_Missense_Mutation_p.V589M|AP1B1_ENST00000415447.1_Missense_Mutation_p.V589M|AP1B1_ENST00000405198.1_Missense_Mutation_p.V589M|AP1B1_ENST00000402502.1_Missense_Mutation_p.V589M	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	589	Pro-rich (stalk region).				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						CTCTTGTGCACGACGCCCCGG	0.627000													7	61					0	0	1	0	0
PPIL1	51645	broad.mit.edu	37	6	36839520	36839520	+	Missense_Mutation	SNP	A	A	T			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr6:36839520A>T	ENST00000373699.5	-	2	436	c.185T>A	c.(184-186)aTc>aAc	p.I62N		NM_016059.4	NP_057143.1	Q9Y3C6	PPIL1_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 1	62	Cyclosporin A binding.|PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			lung(1)|ovary(1)	2						ACCTCCTTGGATCATGAAGTC	0.398000													41	54					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3633188	3633188	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr16:3633188G>A	ENST00000294008.3	-	14	5703	c.5063C>T	c.(5062-5064)cCa>cTa	p.P1688L	RP11-461A8.1_ENST00000573982.1_lincRNA	NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1688	Interaction with PLK1 and TERF2-TERF2IP.|Interaction with SLX1.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						ATTGAGGCCTGGAGGTGCCTC	0.587000								Direct reversal of damage					44	60					0	0	1	0	0
TPCN1	53373	broad.mit.edu	37	12	113707646	113707646	+	Silent	SNP	C	C	T			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr12:113707646C>T	ENST00000550785.1	+	8	1129	c.960C>T	c.(958-960)atC>atT	p.I320I	TPCN1_ENST00000541517.1_Silent_p.I320I|TPCN1_ENST00000392569.4_Silent_p.I180I|TPCN1_ENST00000335509.6_Silent_p.I248I	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	248						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						TCTTTGCCATCCTCGGTGAGT	0.567000													18	74					0	0	1	0	0
FBXO24	26261	broad.mit.edu	37	7	100192027	100192027	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr7:100192027T>C	ENST00000241071.6	+	6	1137	c.815T>C	c.(814-816)tTg>tCg	p.L272S	PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000427939.2_Missense_Mutation_p.L310S|FBXO24_ENST00000468962.1_Missense_Mutation_p.L260S|FBXO24_ENST00000360609.2_Missense_Mutation_p.L258S|FBXO24_ENST00000465843.1_Missense_Mutation_p.L258S|PCOLCE-AS1_ENST00000544873.1_RNA	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	272						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					ATCTACTCTTTGGTAGTGAAT	0.557000													35	78					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156928533	156928533	+	Splice_Site	SNP	C	C	T			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr1:156928533C>T	ENST00000368194.3	-	17	2542		c.e17+1		ARHGEF11_ENST00000361409.2_Splice_Site	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11						actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GAAAGACTCACAAAATATCTC	0.532000													10	16					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238275436	238275436	+	Silent	SNP	G	G	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr2:238275436G>A	ENST00000295550.4	-	11	5846	c.5394C>T	c.(5392-5394)cgC>cgT	p.R1798R	COL6A3_ENST00000353578.4_Silent_p.R1592R|COL6A3_ENST00000409809.1_Silent_p.R1592R|COL6A3_ENST00000346358.4_Silent_p.R1598R|COL6A3_ENST00000347401.3_Silent_p.R1597R|COL6A3_ENST00000472056.1_Silent_p.R1191R	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1798	Nonhelical region.|VWFA 9.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CGTTGCCCACGCGGAACGCTG	0.547000													21	75					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724757	138724757	+	Silent	SNP	C	C	G	rs11924188	by1000genomes	TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr3:138724757C>G	ENST00000383163.2	-	1	353	c.354G>C	c.(352-354)tcG>tcC	p.S118S	MRPS22_ENST00000495075.1_5'UTR	NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	118										endometrium(3)|kidney(1)|lung(7)	11						GCCCAGCAGACGAGTCGTCCT	0.617000													4	30					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				47	31					0	0	1	0	0
ZNF594	84622	broad.mit.edu	37	17	5085881	5085881	+	Silent	SNP	T	T	C			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr17:5085881T>C	ENST00000399604.4	-	1	1811	c.1671A>G	c.(1669-1671)ggA>ggG	p.G557G	ZNF594_ENST00000575779.1_Silent_p.G557G			Q96JF6	ZN594_HUMAN	zinc finger protein 594	557					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TTTTCTGCTCTCCCCTAAGCT	0.473000													7	95					0	0	1	0	0
CENPI	2491	broad.mit.edu	37	X	100382593	100382593	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chrX:100382593C>T	ENST00000372927.1	+	10	1290	c.1013C>T	c.(1012-1014)tCa>tTa	p.S338L	CENPI_ENST00000423383.1_Missense_Mutation_p.S338L|CENPI_ENST00000218507.5_Missense_Mutation_p.S338L|CENPI_ENST00000372926.1_Missense_Mutation_p.S338L	NM_006733.2	NP_006724.2	Q92674	CENPI_HUMAN	centromere protein I	338					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding	p.S338L(1)		breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(19)|prostate(1)|skin(2)	30						AGAAGTGGATCATTTCCACTA	0.378000													19	47					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13121	13121	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chrM:13121G>A	ENST00000361567.2	+	1	785	c.785G>A	c.(784-786)cGc>cAc	p.R262H				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	262					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	CTTACTCATCCGCTTCCACCC	0.527000													7	89					0	0	1	0	0
SLC25A37	51312	broad.mit.edu	37	8	23429210	23429210	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr8:23429210C>T	ENST00000519973.1	+	4	1057	c.859C>T	c.(859-861)Cgg>Tgg	p.R287W		NM_016612.2	NP_057696.2	Q9NYZ2	MFRN1_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 37	287					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				NS(1)|endometrium(3)|large_intestine(2)|lung(8)|urinary_tract(1)	15		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)		CAATGCCTTCCGGACGGTGTA	0.607000													11	33					0	0	1	0	0
CTC-338M12.9	0	broad.mit.edu	37	5	180708697	180708698	+	RNA	INS	-	-	A	rs1815381		TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr5:180708697_180708698insA	ENST00000412295.2	+	0	238																											ggggcggtaggcgggggctgga	0.718													4	6	---	---	---	---					
AGAP4	119016	broad.mit.edu	37	10	46342668	46342688	+	In_Frame_Del	DEL	GCTCCTGCCATCCTGTCCCCA	GCTCCTGCCATCCTGTCCCCA	-			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr10:46342668_46342688delGCTCCTGCCATCCTGTCCCCA	ENST00000448048.2	-	1	233_253	c.108_128delTGGGGACAGGATGGCAGGAGC	c.(106-129)gcg>gc	p.AGDRMAGA36del	AGAP4_ENST00000430779.2_5'UTR	NM_133446.2	NP_597703.2	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4	36					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding	p.G37_A43delGDRMAGA(1)		central_nervous_system(1)|lung(1)|ovary(1)	3						AGCCATGGGCGCTCCTGCCATCCTGTCCCCAGCTCCTGCCT	0.588													3	6	---	---	---	---					
KRTAP5-2	440021	broad.mit.edu	37	11	1619173	1619202	+	In_Frame_Del	DEL	CCCCCACAGGAGCCACAGCCCCCCTTGGAG	CCCCCACAGGAGCCACAGCCCCCCTTGGAG	-	rs61869706	by1000genomes	TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr11:1619173_1619202delCCCCCACAGGAGCCACAGCCCCCCTTGGAG	ENST00000412090.1	-	1	322_351	c.279_308delCTCCAAGGGGGGCTGTGGCTCCTGTGGGGG	c.(277-309)ggt>gg	p.GSKGGCGSCGG93del	KRTAP5-AS1_ENST00000424148.1_RNA	NM_001004325.1	NP_001004325.1	Q701N4	KRA52_HUMAN	keratin associated protein 5-2	93	6 X 4 AA repeats of C-C-X-P.					keratin filament				large_intestine(1)|lung(2)|skin(1)	4		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCCCTTGGAACCCCCACAGGAGCCACAGCCCCCCTTGGAGCCCCCACAGG	0.657													29	171	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738793	102738794	+	RNA	INS	-	-	T	rs35342965	by1000genomes	TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr11:102738793_102738794insT	ENST00000532855.1	-	0	727_728							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGAGGAACAAGTGGTGCCTAAG	0.416													7	4	---	---	---	---					
GNB3	2784	broad.mit.edu	37	12	6954899	6954899	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr12:6954899delC	ENST00000229264.3	+	10	1254	c.849delC	c.(847-849)cgfs	p.R283fs	CDCA3_ENST00000422785.3_3'UTR|GNB3_ENST00000435982.2_Frame_Shift_Del_p.R282fs|CDCA3_ENST00000604599.1_5'UTR	NM_002075.2	NP_002066.1	P16520	GBB3_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 3	283					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|stomach(1)	20						TCAGTGGCCGCCTACTATTCG	0.602													55	166	---	---	---	---					
PLEKHA8P1	0	broad.mit.edu	37	12	45566878	45566878	+	RNA	DEL	T	T	-			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr12:45566878delT	ENST00000256692.5	-	0	1807					NR_037144.1															breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						tttatttttatttttttttAC	0.299													2	4	---	---	---	---					
RP11-248G5.8	0	broad.mit.edu	37	13	52803642	52803642	+	RNA	DEL	T	T	-			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr13:52803642delT	ENST00000451298.1	-	0	938				RP11-64P12.8_ENST00000606031.1_RNA																							CAGTTTTCCCTTTTTTTTTTT	0.328													2	4	---	---	---	---					
GGNBP2	79893	broad.mit.edu	37	17	34901690	34901691	+	Frame_Shift_Ins	INS	-	-	C			TCGA-EL-A3ZM-01A-12D-A23M-08	TCGA-EL-A3ZM-11A-12D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8b8c8e57-8a4d-4881-bc1c-bddd6c4ca3e3	f6362e17-a8ee-444b-af2c-2d2b8c7a807d	g.chr17:34901690_34901691insC	ENST00000485685.2	+	2	409_410	c.117_118insC	c.(115-120)ggccgcfs	p.R40fs	GGNBP2_ENST00000304718.4_Intron			Q9H3C7	GGNB2_HUMAN	gametogenetin binding protein 2	0					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)	38		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		gccgggctgggcccgccgcTCC	0.678													3	4	---	---	---	---					
