Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KBTBD7	84078	broad.mit.edu	37	13	41768120	41768120	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr13:41768120C>G	ENST00000379483.3	-	1	582	c.274G>C	c.(274-276)Gcg>Ccg	p.A92P		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	92	BTB.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		TAGGGACACGCAGCTGCTAGC	0.617000													8	47					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16436472	16436472	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr9:16436472T>C	ENST00000380672.4	-	6	1777	c.1720A>G	c.(1720-1722)Aga>Gga	p.R574G	BNC2_ENST00000380666.2_Missense_Mutation_p.R574G|BNC2_ENST00000545497.1_Missense_Mutation_p.R479G|BNC2_ENST00000380667.2_Missense_Mutation_p.R507G	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	574	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		AGTAAACTTCTATAAAATGGA	0.507000													30	62					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													3	35					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91090988	91090988	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chrX:91090988C>T	ENST00000373094.1	+	1	1330	c.485C>T	c.(484-486)gCg>gTg	p.A162V	PCDH11X_ENST00000361724.1_Missense_Mutation_p.A162V|PCDH11X_ENST00000361655.2_Missense_Mutation_p.A162V|PCDH11X_ENST00000504220.1_Missense_Mutation_p.A162V|PCDH11X_ENST00000298274.8_Missense_Mutation_p.A162V|PCDH11X_ENST00000395337.2_Missense_Mutation_p.A162V|PCDH11X_ENST00000406881.1_Missense_Mutation_p.A162V|PCDH11X_ENST00000373097.1_Missense_Mutation_p.A162V|PCDH11X_ENST00000373088.1_Missense_Mutation_p.A162V	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	162	Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						ACTCTCCCAGCGGCTGTTGAT	0.343000													5	52					0	0	1	0	0
MT-ATP6	4508	broad.mit.edu	37	MT	9114	9114	+	Silent	SNP	A	A	G			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chrM:9114A>G	ENST00000361899.2	+	1	588	c.588A>G	c.(586-588)ctA>ctG	p.L196L						mitochondrially encoded ATP synthase 6											breast(2)|endometrium(7)|kidney(8)|prostate(1)	18						TTCACAATTCTAATTCTACTG	0.438000													4	6					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R|HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			80	71					0	0	1	0	0
RDH14	57665	broad.mit.edu	37	2	18736681	18736681	+	Missense_Mutation	SNP	A	A	T			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr2:18736681A>T	ENST00000381249.3	-	2	894	c.787T>A	c.(787-789)Ttg>Atg	p.L263M	RDH14_ENST00000468071.1_5'UTR	NM_020905.3	NP_065956.1			retinol dehydrogenase 14 (all-trans/9-cis/11-cis)											breast(2)|endometrium(1)|large_intestine(2)|lung(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)					GGTTTGACCAACAGTGGAATG	0.473000													47	133					0	0	1	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998675	8998675	+	Silent	SNP	T	T	G			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr8:8998675T>G	ENST00000310455.3	-	2	637	c.487A>C	c.(487-489)Agg>Cgg	p.R163R	PPP1R3B_ENST00000519699.1_Silent_p.R163R	NM_001201329.1|NM_024607.3	NP_001188258.1|NP_078883.2	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory subunit 3B	163	CBM21.				glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		AACGTCATCCTTATTTTCACG	0.512000													80	84					0	0	1	0	0
POMGNT1	55624	broad.mit.edu	37	1	46663383	46663383	+	Silent	SNP	T	T	C			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr1:46663383T>C	ENST00000396420.3	-	2	747	c.111A>G	c.(109-111)agA>agG	p.R37R	POMGNT1_ENST00000371984.3_Silent_p.R37R|POMGNT1_ENST00000371992.1_Silent_p.R37R|POMGNT1_ENST00000371986.3_Silent_p.R37R			Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	37					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					CCTGACAGAATCTCCGCAGGG	0.602000													31	76					0	0	1	0	0
ABO	28	broad.mit.edu	37	9	136131223	136131223	+	RNA	SNP	C	C	T			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr9:136131223C>T	ENST00000453660.2	-	0	905							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		TCGTGCCACACGGCCTCGATG	0.662000													18	75					0	0	1	0	0
CLDN10	9071	broad.mit.edu	37	13	96086195	96086195	+	Silent	SNP	G	G	A	rs149372773	byFrequency	TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr13:96086195G>A	ENST00000376873.3	+	1	338	c.108G>A	c.(106-108)tcG>tcA	p.S36S		NM_001160100.1|NM_182848.3	NP_001153572.1|NP_878268.1	P78369	CLD10_HUMAN	claudin 10	38					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			GAGCCTCCTCGGTGATAACAG	0.552000													4	71					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1271213	1271213	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr11:1271213C>A	ENST00000447027.1	+	31	13170	c.13112C>A	c.(13111-13113)aCg>aAg	p.T4371K	MUC5B_ENST00000529681.1_Missense_Mutation_p.T4368K			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4368	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTGCTGACCACGAAGGCCACC	0.642000													133	91					1.74062e-63	1.79501e-63	1	1	0
OR5B17	219965	broad.mit.edu	37	11	58126180	58126180	+	Silent	SNP	G	G	A	rs146597451		TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr11:58126180G>A	ENST00000357377.3	-	1	362	c.363C>T	c.(361-363)taC>taT	p.Y121Y		NM_001005489.1	NP_001005489.1	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B, member 17	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				ACACTGCTGCGTAGCGGTCAT	0.473000													19	74					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41768119	41768119	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr13:41768119G>A	ENST00000379483.3	-	1	583	c.275C>T	c.(274-276)gCg>gTg	p.A92V		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	92	BTB.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		GTAGGGACACGCAGCTGCTAG	0.617000													8	46					0	0	1	0	0
LRP10	26020	broad.mit.edu	37	14	23345001	23345001	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr14:23345001C>T	ENST00000359591.4	+	5	1535	c.844C>T	c.(844-846)Cag>Tag	p.Q282*	LRP10_ENST00000546834.1_Nonsense_Mutation_p.Q282*	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	282	CUB 2.				endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		ACTGTCTGGCCAGGCTGTTGT	0.582000													39	83					0	0	1	0	0
RFXAP	5994	broad.mit.edu	37	13	37399626	37399626	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr13:37399626C>A	ENST00000255476.2	+	2	796	c.662C>A	c.(661-663)cCt>cAt	p.P221H	RFXAP_ENST00000472888.1_3'UTR	NM_000538.3	NP_000529.1	O00287	RFXAP_HUMAN	regulatory factor X-associated protein	221	C-terminal domain.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)	4		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		GGGGATCGTCCTGCAAGACCT	0.308000													18	30					3.32936e-07	3.32936e-07	1	1	0
MAP3K15	389840	broad.mit.edu	37	X	19389610	19389610	+	Silent	SNP	C	C	T			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chrX:19389610C>T	ENST00000338883.4	-	23	3146	c.3147G>A	c.(3145-3147)aaG>aaA	p.K1049K	MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000469203.2_Silent_p.K881K|MAP3K15_ENST00000359173.3_Silent_p.K484K	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	1049							ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					CAATGATTTGCTTGATGTGTC	0.478000													42	59					0	0	1	0	0
EPC2	26122	broad.mit.edu	37	2	149528907	149528907	+	Silent	SNP	T	T	G			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr2:149528907T>G	ENST00000258484.6	+	10	1705	c.1671T>G	c.(1669-1671)gtT>gtG	p.V557V		NM_015630.3	NP_056445.3	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2 (Drosophila)	557					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0516)		ATAAAAGAGTTTCTGCAGCAT	0.383000													19	76					0	0	1	0	0
PLCB3	5331	broad.mit.edu	37	11	64028911	64028911	+	Missense_Mutation	SNP	T	T	G			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr11:64028911T>G	ENST00000540288.1	+	15	1874	c.1771T>G	c.(1771-1773)Tcc>Gcc	p.S591A	PLCB3_ENST00000279230.6_Missense_Mutation_p.S591A|PLCB3_ENST00000325234.5_Missense_Mutation_p.S524A	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	591	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						TGAGGAGATGTCCACGCTTGT	0.607000													11	120					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13101	13101	+	Silent	SNP	A	A	C			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chrM:13101A>C	ENST00000361567.2	+	1	765	c.765A>C	c.(763-765)gcA>gcC	p.A255A				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	255					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	ATAGTTGTAGCAGGAATCTTC	0.517000													7	16					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56373475	56373475	+	Silent	SNP	G	G	A			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr19:56373475G>A	ENST00000301295.6	+	5	2558	c.2136G>A	c.(2134-2136)agG>agA	p.R712R	NLRP4_ENST00000346986.5_Silent_p.R712R|NLRP4_ENST00000587891.1_Silent_p.R637R	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	712							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ATGACATCAGGTCCCTCTGTG	0.473000													5	89					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23401754	23401754	+	Silent	SNP	C	C	T			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr22:23401754C>T	ENST00000216036.4	-	7	1129	c.933G>A	c.(931-933)acG>acA	p.T311T		NM_014433.2	NP_055248.1	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region gene 1	311							binding			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	18	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		TGGGCACGTGCGTCTGCAGGG	0.637000													40	140					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310279	57310279	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr11:57310279A>G	ENST00000457912.1	+	2	218	c.218A>G	c.(217-219)aAg>aGg	p.K73R	SMTNL1_ENST00000399154.2_Missense_Mutation_p.K55R|SMTNL1_ENST00000527972.1_Missense_Mutation_p.K55R			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	55										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						AAGCAGGAAAAGGCACCAGCC	0.567000													3	35					0	0	1	0	0
RP5-896L10.1	0	broad.mit.edu	37	1	99474094	99474095	+	RNA	DEL	AA	AA	-	rs57656522		TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr1:99474094_99474095delAA	ENST00000425113.1	+	0	370					NR_033940.1																						AACAGCAACTAAAAAAAAAAAA	0.356													2	4	---	---	---	---					
INTU	27152	broad.mit.edu	37	4	128564831	128564832	+	Frame_Shift_Ins	INS	-	-	T			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr4:128564831_128564832insT	ENST00000335251.5	+	2	405_406	c.302_303insT	c.(301-303)taafs	p.*101fs	INTU_ENST00000296461.5_Frame_Shift_Ins_p.*101fs	NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	101										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						GAAGATGACTACAAAGAAAGAA	0.361													7	151	---	---	---	---					
RP11-262H14.3	0	broad.mit.edu	37	9	66545704	66545704	+	RNA	DEL	C	C	-	rs12353356		TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr9:66545704delC	ENST00000445604.2	-	0	669																											GAAAAAAAAACAAAGAAAGAA	0.373													2	4	---	---	---	---					
RP11-65M17.3	0	broad.mit.edu	37	11	112332121	112332121	+	RNA	DEL	T	T	-			TCGA-EL-A3ZR-01A-11D-A23M-08	TCGA-EL-A3ZR-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ef14112d-0d01-4b95-9d74-61973fcb5a89	99efb2b0-1cf3-455d-83ba-f2a81b958a33	g.chr11:112332121delT	ENST00000528496.1	+	0	231																											TGATTTTATGTTTTTTTTTTT	0.378													4	8	---	---	---	---					
