Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANPEP	290	broad.mit.edu	37	15	90349592	90349592	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr15:90349592G>A	ENST00000300060.6	-	2	536	c.223C>T	c.(223-225)Cgc>Tgc	p.R75C		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	75	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TTGGGGAGGCGGTAACGATTC	0.627000													5	71					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14024093	14024093	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr19:14024093G>A	ENST00000318003.7	+	5	732	c.491G>A	c.(490-492)cGg>cAg	p.R164Q	CC2D1A_ENST00000589606.1_Missense_Mutation_p.R164Q	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	164					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GCCAAGATGCGGCGCTACGAT	0.622000													15	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179441971	179441971	+	Nonsense_Mutation	SNP	C	C	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr2:179441971C>A	ENST00000589042.1	-	324	69315	c.69091G>T	c.(69091-69093)Gaa>Taa	p.E23031*	TTN_ENST00000359218.5_Nonsense_Mutation_p.E14091*|RP11-171I2.5_ENST00000604215.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.E14158*|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.E20463*|TTN_ENST00000460472.2_Nonsense_Mutation_p.E13966*|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.E21390*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21390	Fibronectin type-III 67.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCACATGTTCCACCTTCGTG	0.448000													3	29					0.115264	0.115264	1	1	0
NRAS	4893	broad.mit.edu	37	1	115256530	115256530	+	Missense_Mutation	SNP	G	G	T	rs121913254		TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr1:115256530G>T	ENST00000369535.4	-	3	434	c.181C>A	c.(181-183)Caa>Aaa	p.Q61K		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61K(595)|p.Q61E(9)|p.Q61L(3)|p.Q61R(2)|p.G60>?(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTCTTGTCCAGCTGTA	0.458000	Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(HCC15_LUNG)|Q61K(HS936T_SKIN)|Q61K(HS944T_SKIN)|Q61K(HT1080_SOFT_TISSUE)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH1299_LUNG)|Q61K(NCIH2087_LUNG)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(TYKNU_OVARY)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			55	70					2.2129e-31	2.56982e-31	1	1	0
CCDC171	203238	broad.mit.edu	37	9	15579022	15579022	+	Splice_Site	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr9:15579022G>A	ENST00000380701.3	+	4	680		c.e4+1		CCDC171_ENST00000297641.3_Splice_Site|CCDC171_ENST00000535968.1_Splice_Site	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171																		AAACTCTGTGGTAAGACTGTT	0.443000													18	26					0	0	1	0	0
GPRC5B	0	broad.mit.edu	37	16	19883141	19883141	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr16:19883141C>A	ENST00000300571.2	-	2	1218	c.1027G>T	c.(1027-1029)Gca>Tca	p.A343S	GPRC5B_ENST00000569847.1_Missense_Mutation_p.A343S|GPRC5B_ENST00000569479.1_Missense_Mutation_p.A343S|GPRC5B_ENST00000537135.1_Missense_Mutation_p.A369S|GPRC5B_ENST00000535671.1_Missense_Mutation_p.A343S	NM_016235.1	NP_057319.1	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5, member B	343										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						ACTTTACCTGCATTGTGTTCA	0.602000													23	49					7.76418e-22	8.73471e-22	1	1	0
SEPSECS	51091	broad.mit.edu	37	4	25160718	25160718	+	Silent	SNP	T	T	C			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr4:25160718T>C	ENST00000382103.2	-	2	198	c.126A>G	c.(124-126)ccA>ccG	p.P42P	SEPSECS_ENST00000302922.3_Intron	NM_016955.3	NP_058651.3	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	42					selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding			endometrium(1)|large_intestine(4)|lung(2)|stomach(1)	8		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	AGCCATTCTCTGGACACTTGC	0.343000													10	19					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000429426.2_Silent_p.S163S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								4	53					0	0	1	0	0
MST1L	0	broad.mit.edu	37	1	17084755	17084755	+	RNA	SNP	T	T	C	rs140682808	by1000genomes	TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr1:17084755T>C	ENST00000455405.2	-	0	261																											ACTGCTCCTTTACTAGAGACC	0.577000													6	12					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803543	142803543	+	RNA	SNP	C	C	T			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr1:142803543C>T	ENST00000423385.1	-	0	1422																											TGTTGGAATTCCTGATGAATC	0.269000													4	166					0	0	1	0	0
HSPA5	3309	broad.mit.edu	37	9	127998975	127998975	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr9:127998975T>C	ENST00000324460.6	-	8	2064	c.1861A>G	c.(1861-1863)Aag>Gag	p.K621E		NM_005347.4	NP_005338.1	P11021	GRP78_HUMAN	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	621					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding	p.K621E(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|prostate(2)|skin(1)	23					Antihemophilic Factor(DB00025)	TCCAGTTCCTTCTTCTTAGCT	0.423000										Prostate(1;0.17)			30	41					0	0	1	0	0
STAG3L4	0	broad.mit.edu	37	7	66767840	66767840	+	RNA	SNP	G	G	C			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr7:66767840G>C	ENST00000416602.2	+	0	233					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				AGGCAGGAGCGGCGGCCCAGC	0.711000													7	5					0	0	1	0	0
GPRC5B	0	broad.mit.edu	37	16	19883140	19883140	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr16:19883140G>A	ENST00000300571.2	-	2	1219	c.1028C>T	c.(1027-1029)gCa>gTa	p.A343V	GPRC5B_ENST00000569847.1_Missense_Mutation_p.A343V|GPRC5B_ENST00000569479.1_Missense_Mutation_p.A343V|GPRC5B_ENST00000537135.1_Missense_Mutation_p.A369V|GPRC5B_ENST00000535671.1_Missense_Mutation_p.A343V	NM_016235.1	NP_057319.1	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5, member B	343										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						CACTTTACCTGCATTGTGTTC	0.597000													23	47					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907884	77907884	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr15:77907884C>T	ENST00000355300.6	-	2	539	c.365G>A	c.(364-366)cGg>cAg	p.R122Q	LINGO1_ENST00000561030.1_Missense_Mutation_p.R116Q	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	122					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						ACCCAGCGTCCGGAGGTTGAA	0.617000													8	16					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70823900	70823900	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chrX:70823900G>A	ENST00000373695.1	+	7	1310	c.773G>A	c.(772-774)aGc>aAc	p.S258N	ACRC_ENST00000373696.3_Missense_Mutation_p.S258N			Q96QF7	ACRC_HUMAN	acidic repeat containing	258	Asp/Ser-rich.					nucleus		p.S258N(2)		autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					CCCGACGACAGCAGTGATGAT	0.557000													4	123					0	0	1	0	0
IGSF9	57549	broad.mit.edu	37	1	159906610	159906610	+	Silent	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr1:159906610G>A	ENST00000368094.1	-	5	686	c.489C>T	c.(487-489)agC>agT	p.S163S	IGSF9_ENST00000361509.3_Silent_p.S163S	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	163	Ig-like 2.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GAGGCAGGGGGCTGCCACGGG	0.617000											OREG0013921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	38					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44948680	44948680	+	Nonsense_Mutation	SNP	A	A	T			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr3:44948680A>T	ENST00000296125.4	+	10	1383	c.1315A>T	c.(1315-1317)Aag>Tag	p.K439*		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	439					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	CTATGAGTACAAGTATCCAGA	0.512000													9	85					0	0	1	0	0
APOBEC3C	27350	broad.mit.edu	37	22	39414360	39414360	+	Silent	SNP	C	C	T			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr22:39414360C>T	ENST00000361441.3	+	4	821	c.541C>T	c.(541-543)Ctg>Ttg	p.L181L	APOBEC3D_ENST00000381568.4_Intron	NM_014508.2	NP_055323.2	Q9NRW3	ABC3C_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C	181					DNA demethylation|interspecies interaction between organisms|negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|protein binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)|skin(1)	6	Melanoma(58;0.04)					CTTTCGACTTCTGAAAAGAAG	0.473000													80	123					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9013858	9013858	+	Silent	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr19:9013858G>A	ENST00000397910.4	-	33	38735	c.38532C>T	c.(38530-38532)ctC>ctT	p.L12844L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12846				Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGGGCTGGGGAGGGAGGATG	0.478000													3	23					0	0	1	0	0
GSDMA	284110	broad.mit.edu	37	17	38128401	38128401	+	Missense_Mutation	SNP	T	T	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr17:38128401T>A	ENST00000301659.4	+	6	793	c.675T>A	c.(673-675)aaT>aaA	p.N225K		NM_178171.4	NP_835465.2	Q96QA5	GSDMA_HUMAN	gasdermin A	225					apoptosis|induction of apoptosis	perinuclear region of cytoplasm				NS(1)|endometrium(2)|large_intestine(3)|lung(1)	7						ATATCTGCAATGATAACATGC	0.517000													5	5					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39854046	39854046	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr1:39854046G>A	ENST00000564288.1	+	58	16309	c.15532G>A	c.(15532-15534)Gcc>Acc	p.A5178T	MACF1_ENST00000545844.1_Missense_Mutation_p.A3116T|MACF1_ENST00000361689.2_Missense_Mutation_p.A3116T|MACF1_ENST00000289893.4_Missense_Mutation_p.A3618T|MACF1_ENST00000539005.1_Missense_Mutation_p.A3095T|MACF1_ENST00000372915.3_Missense_Mutation_p.A5183T|MACF1_ENST00000317713.7_Missense_Mutation_p.A3116T|MACF1_ENST00000567887.1_Missense_Mutation_p.A5215T			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5183					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGACATAGAGGCCTCTGAAGC	0.473000													18	17					0	0	1	0	0
EIF1AX	1964	broad.mit.edu	37	X	20148693	20148693	+	Nonsense_Mutation	SNP	C	C	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chrX:20148693C>A	ENST00000379607.5	-	6	573	c.370G>T	c.(370-372)Gga>Tga	p.G124*	EIF1AX_ENST00000379593.1_Nonsense_Mutation_p.G96*	NM_001412.3	NP_001403.1	P47813	IF1AX_HUMAN	eukaryotic translation initiation factor 1A, X-linked	124						cytosol	translation initiation factor activity			endometrium(2)|lung(1)|ovary(1)|prostate(1)	5						TCATCATCTCCAGGACCAAAT	0.323000													21	43					7.45023e-12	8.12752e-12	1	1	0
FMNL1	752	broad.mit.edu	37	17	43321229	43321229	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr17:43321229G>A	ENST00000331495.3	+	18	2621	c.2285G>A	c.(2284-2286)cGc>cAc	p.R762H	FMNL1_ENST00000587489.1_Missense_Mutation_p.R340H|FMNL1_ENST00000328118.3_Missense_Mutation_p.R762H	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	762	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						GAGTATGAGCGCAGCCTCATC	0.637000													15	19					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	26					0	0	1	0	0
NSUN5	55695	broad.mit.edu	37	7	72717996	72717996	+	Silent	SNP	G	G	C			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr7:72717996G>C	ENST00000428206.1	-	8	871	c.858C>G	c.(856-858)ggC>ggG	p.G286G	NSUN5_ENST00000310326.8_Silent_p.G324G|NSUN5_ENST00000252594.6_Silent_p.G324G|NSUN5_ENST00000438747.2_Silent_p.G324G	NM_001168348.1	NP_001161820.1	Q96P11	NSUN5_HUMAN	NOP2/Sun domain family, member 5	324	S-adenosyl-L-methionine binding.						methyltransferase activity			breast(1)|endometrium(3)|large_intestine(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	8		Lung NSC(55;0.163)				GGCTAGGTGTGCCTGCCCCGG	0.607000													3	32					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000377425.4_Intron|AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000539936.1_3'UTR			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													4	67					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612098	20612098	+	Missense_Mutation	SNP	A	A	C			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr14:20612098A>C	ENST00000333629.1	+	1	204	c.204A>C	c.(202-204)ttA>ttC	p.L68F		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		ACTTGGCCTTACTGGATGCAT	0.478000													4	172					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96000545	96000545	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr9:96000545C>T	ENST00000297954.4	+	5	1264	c.1264C>T	c.(1264-1266)Cac>Tac	p.H422Y	WNK2_ENST00000395477.2_Missense_Mutation_p.H422Y|WNK2_ENST00000427277.2_Missense_Mutation_p.H34Y|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.H34Y|WNK2_ENST00000395475.2_Missense_Mutation_p.H408Y			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	422	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						TGAGAAAGTGCACGATCCTGA	0.557000													3	30					0	0	1	0	0
SHCBP1	79801	broad.mit.edu	37	16	46629511	46629511	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr16:46629511T>G	ENST00000303383.3	-	10	1683	c.1417A>C	c.(1417-1419)Aca>Cca	p.T473P		NM_024745.4	NP_079021.3	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	473										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				TCTGCTGATGTCCGCACTGTG	0.453000													24	22					0	0	1	0	0
EIF1AX	1964	broad.mit.edu	37	X	20148692	20148692	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chrX:20148692C>A	ENST00000379607.5	-	6	574	c.371G>T	c.(370-372)gGa>gTa	p.G124V	EIF1AX_ENST00000379593.1_Missense_Mutation_p.G96V	NM_001412.3	NP_001403.1	P47813	IF1AX_HUMAN	eukaryotic translation initiation factor 1A, X-linked	124						cytosol	translation initiation factor activity			endometrium(2)|lung(1)|ovary(1)|prostate(1)	5						ATCATCATCTCCAGGACCAAA	0.328000													22	43					1.50039e-11	1.58865e-11	1	1	0
RAB6B	51560	broad.mit.edu	37	3	133558368	133558368	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr3:133558368G>A	ENST00000285208.4	-	5	732	c.383C>T	c.(382-384)aCg>aTg	p.T128M	RAB6B_ENST00000486858.1_Missense_Mutation_p.T115M|RAB6B_ENST00000469959.1_Intron|RAB6B_ENST00000543906.1_Missense_Mutation_p.T128M	NM_016577.3	NP_057661.3	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	128					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	11						AGCCAGGTCCGTCTTGTTGCC	0.562000													33	40					0	0	1	0	0
RP11-584P21.2	0	broad.mit.edu	37	4	68311853	68311855	+	RNA	DEL	GAG	GAG	-			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr4:68311853_68311855delGAG	ENST00000502400.1	-	0	34																											TCTCTATGGCGAGGAGGAGGAGG	0.547													2	4	---	---	---	---					
TRERF1	55809	broad.mit.edu	37	6	42204105	42204106	+	In_Frame_Ins	INS	-	-	TCC	rs146190272	by1000genomes	TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr6:42204105_42204106insTCC	ENST00000541110.1	-	16	3531_3532	c.2963_2964insGGA	c.(2962-2964)gcc>gGGAcc	p.988_988A>GT	TRERF1_ENST00000372917.4_In_Frame_Ins_p.885_885A>GT|TRERF1_ENST00000340840.2_In_Frame_Ins_p.885_885A>GT|TRERF1_ENST00000354325.2_In_Frame_Ins_p.885_885A>GT|TRERF1_ENST00000372922.4_In_Frame_Ins_p.968_968A>GT			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	968	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTTCCGGGtcctcctcctc	0.530													3	3	---	---	---	---					
MSLNL	401827	broad.mit.edu	37	16	830765	830766	+	In_Frame_Ins	INS	-	-	CAG			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr16:830765_830766insCAG	ENST00000293892.3	-	3	234_235	c.235_236insCTG	c.(235-237)cac>CTGcac	p.78_79insL	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	0					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						CGGGTAGGTGACGGTGTGCACG	0.589													10	36	---	---	---	---					
MTSS1L	92154	broad.mit.edu	37	16	70699375	70699375	+	Frame_Shift_Del	DEL	G	G	-			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr16:70699375delG	ENST00000338779.6	-	12	1396	c.1122delC	c.(1120-1122)ccfs	p.P374fs	FLJ00418_ENST00000597002.1_3'UTR	NM_138383.2	NP_612392.1	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	374	Ser-rich.				filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(1)|liver(1)|lung(1)|skin(1)	7						TGACCGAGGTGGGGGAGCTGC	0.652													2	4	---	---	---	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	In_Frame_Del	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	rs483929	by1000genomes	TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	ENST00000398472.1	-	1	742_798	c.255_311delCCCACTCTGCTGTCAGACCACCTGCCACCCCAGCTGTGGTATGTCCAGCTGCTGCCG	c.(253-312)cgt>cg	p.RPLCCQTTCHPSCGMSSCCR85del				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	85	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].		Missing (in allele KAP4.10).			keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													66	21	---	---	---	---					
FN3KRP	79672	broad.mit.edu	37	17	80684416	80684421	+	In_Frame_Del	DEL	ATGGAC	ATGGAC	-			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr17:80684416_80684421delATGGAC	ENST00000269373.6	+	5	602_607	c.529_534delATGGAC	c.(529-534)del	p.MD177del	FN3KRP_ENST00000535965.1_In_Frame_Del_p.MD127del	NM_024619.3	NP_078895.2	Q9HA64	KT3K_HUMAN	fructosamine 3 kinase related protein	177							kinase activity			breast(1)|large_intestine(2)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	7	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			TCAGCCCCAGATGGACATGGTGGAGA	0.597													41	85	---	---	---	---					
DENND6B	414918	broad.mit.edu	37	22	50751471	50751471	+	Frame_Shift_Del	DEL	G	G	-			TCGA-EM-A3ST-01A-11D-A22Z-08	TCGA-EM-A3ST-11A-11D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c697c70c-6fab-4a19-8ea3-07089ce52e74	d1a1b16d-d9c2-4775-a1a3-0d733a9ca72f	g.chr22:50751471delG	ENST00000413817.2	-	17	1485	c.1414delC	c.(1414-1416)agfs	p.Q472fs		NM_001001794.3	NP_001001794.3			DENN/MADD domain containing 6B																		CAGGTGAGCTGGGGCCCAGCA	0.647													2	4	---	---	---	---					
