Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SEPT12	124404	broad.mit.edu	37	16	4834039	4834039	+	Silent	SNP	C	C	T			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr16:4834039C>T	ENST00000268231.8	-	5	668	c.405G>A	c.(403-405)gaG>gaA	p.E135E	SEPT12_ENST00000396693.5_Intron	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	135					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						GCTCGTATTGCTCGTTGATGT	0.627000													32	75					0	0	1	0	0
CAPNS2	84290	broad.mit.edu	37	16	55601279	55601279	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr16:55601279T>C	ENST00000457326.2	+	1	696	c.611T>C	c.(610-612)aTg>aCg	p.M204T	LPCAT2_ENST00000565056.1_Intron|LPCAT2_ENST00000262134.5_Intron	NM_032330.1	NP_115706.1	Q96L46	CPNS2_HUMAN	calpain, small subunit 2	204	EF-hand 3.					cytoplasm|plasma membrane	calcium ion binding			central_nervous_system(1)|large_intestine(1)|lung(3)|prostate(2)	7						GATGGAGATATGGATTTTAAC	0.478000													5	169					0	0	1	0	0
BACH1	571	broad.mit.edu	37	21	30693752	30693752	+	Missense_Mutation	SNP	G	G	A	rs149732438	byFrequency	TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr21:30693752G>A	ENST00000399921.1	+	2	394	c.151G>A	c.(151-153)Gtg>Atg	p.V51M	BACH1_ENST00000286800.3_Missense_Mutation_p.V51M	NM_206866.1	NP_996749.1	O14867	BACH1_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 1	51	BTB.					nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|urinary_tract(2)	27						TCACCGGTCCGTGCTGGCGGC	0.522000													4	57					0	0	1	0	0
CSRNP1	64651	broad.mit.edu	37	3	39185421	39185421	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr3:39185421G>A	ENST00000273153.5	-	5	1072	c.895C>T	c.(895-897)Cgc>Tgc	p.R299C	CSRNP1_ENST00000514182.1_Missense_Mutation_p.R299C	NM_033027.3	NP_149016.2	Q96S65	CSRN1_HUMAN	cysteine-serine-rich nuclear protein 1	299					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|skin(3)	24						AACTGCAGGCGGGTGAGTGTG	0.607000													3	26					0	0	1	0	0
AMZ2P1	0	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													4	89					0	0	1	0	0
IGHV3-49	0	broad.mit.edu	37	14	107012975	107012975	+	RNA	SNP	A	A	G			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr14:107012975A>G	ENST00000390625.2	-	0	399																											CTCGGTTTTCAGGCTGTTCAT	0.517000													5	172					0	0	1	0	0
CCT6B	10693	broad.mit.edu	37	17	33279009	33279009	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr17:33279009C>T	ENST00000314144.5	-	5	689	c.574G>A	c.(574-576)Gaa>Aaa	p.E192K	CCT6B_ENST00000436961.3_Missense_Mutation_p.E147K|CCT6B_ENST00000421975.3_Missense_Mutation_p.E192K	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	192					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding	p.E192Q(1)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				TCCATTATTTCTACCATGAAG	0.318000													4	32					0	0	1	0	0
ANKRD30BP2	0	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	G	A	rs2821609	by1000genomes	TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr21:14414902G>A	ENST00000507941.1	+	0	95																											CCAGCTTGACGTCCTTGATGG	0.443000													5	28					0	0	1	0	0
NMD3	51068	broad.mit.edu	37	3	160967245	160967245	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr3:160967245T>G	ENST00000460469.1	+	13	1662	c.1207T>G	c.(1207-1209)Tta>Gta	p.L403V	NMD3_ENST00000472947.1_Missense_Mutation_p.L403V|NMD3_ENST00000351193.2_Missense_Mutation_p.L403V			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	403					protein transport	cytoplasm|nucleolus|nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			CTTGCAGGTATTAATCAAGAA	0.363000													3	10					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65490925	65490925	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr15:65490925C>T	ENST00000261883.4	-	9	1865	c.1699G>A	c.(1699-1701)Gaa>Aaa	p.E567K		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	567					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						ATCTTGATTTCATGGAACACG	0.517000													6	58					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224912	248224912	+	Missense_Mutation	SNP	G	G	T			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr1:248224912G>T	ENST00000359959.3	+	1	929	c.929G>T	c.(928-930)gGg>gTg	p.G310V	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ATCTGCTCTGGGAAAATGTAG	0.438000													3	34					0.004672	0.00489448	1	1	0
CCT6B	10693	broad.mit.edu	37	17	33288338	33288338	+	Silent	SNP	G	G	A			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr17:33288338G>A	ENST00000314144.5	-	1	190	c.75C>T	c.(73-75)tgC>tgT	p.C25C	CCT6B_ENST00000436961.3_Silent_p.C25C|CCT6B_ENST00000421975.3_Silent_p.C25C	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	25				AALAVNICAARGL -> QLWLSIYAPPRV (in Ref. 1; BAA11347).	chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				CTCGGGCGGCGCATATATTGA	0.592000													3	35					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23913960	23913960	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr13:23913960C>T	ENST00000382298.3	-	10	4643	c.4055G>A	c.(4054-4056)aGc>aAc	p.S1352N	SACS_ENST00000402364.1_Missense_Mutation_p.S602N|SACS_ENST00000382292.3_Missense_Mutation_p.S1352N	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1352					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ATTTTGTTTGCTTTCTTGTTC	0.368000													5	44					0	0	1	0	0
IRS2	8660	broad.mit.edu	37	13	110436139	110436139	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr13:110436139C>A	ENST00000375856.3	-	1	2776	c.2262G>T	c.(2260-2262)gaG>gaT	p.E754D		NM_003749.2	NP_003740.2	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	754					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	19	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			CATCTGCATGCTCCATGGACA	0.687000													3	5					0.115264	0.115264	1	1	0
LARP7	51574	broad.mit.edu	37	4	113565889	113565889	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr4:113565889G>A	ENST00000509061.1	+	4	388	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K	LARP7_ENST00000344442.5_Missense_Mutation_p.E22K|LARP7_ENST00000324052.6_Missense_Mutation_p.E22K	NM_001267039.1	NP_001253968.1	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	22	HTH La-type RNA-binding.				RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding			endometrium(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	17		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		AAAGAAAAAAGAAGTTGAAAA	0.353000													13	38					0	0	1	0	0
RARRES2	0	broad.mit.edu	37	7	150037252	150037252	+	Silent	SNP	C	C	T			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr7:150037252C>T	ENST00000466675.1	-	2	1249	c.216G>A	c.(214-216)ctG>ctA	p.L72L	RARRES2_ENST00000223271.3_Silent_p.L72L|RARRES2_ENST00000482669.1_Silent_p.L72L			Q99969	RARR2_HUMAN	retinoic acid receptor responder (tazarotene induced) 2	72					embryonic digestive tract development|in utero embryonic development|positive regulation of macrophage chemotaxis|retinoid metabolic process	extracellular matrix	receptor binding			endometrium(1)|large_intestine(1)|lung(1)|pancreas(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(82;0.011)			TTGTCTGCTGCAGCTTAAATT	0.587000													19	427					0	0	1	0	0
DDX46	9879	broad.mit.edu	37	5	134153187	134153187	+	Splice_Site	SNP	A	A	G			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr5:134153187A>G	ENST00000452510.2	+	20	2773	c.2613_splice	c.e20-1	p.D872_splice	DDX46_ENST00000354283.4_Splice_Site_p.D871_splice	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	871					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TAACTACAGGATGTGATGCAG	0.423000													10	17					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				20	43					0	0	1	0	0
PDSS1	23590	broad.mit.edu	37	10	26994255	26994255	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr10:26994255G>A	ENST00000376215.5	+	4	321	c.268G>A	c.(268-270)Gaa>Aaa	p.E90K	PDSS1_ENST00000376203.5_Missense_Mutation_p.E90K	NM_014317.3	NP_055132.2	Q5T2R2	DPS1_HUMAN	prenyl (decaprenyl) diphosphate synthase, subunit 1	90					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity			autonomic_ganglia(1)|endometrium(1)|kidney(7)|large_intestine(6)|lung(5)|prostate(1)	21						ACACAGTGGTGAAAAATACAC	0.363000													5	25					0	0	1	0	0
PRPF4B	8899	broad.mit.edu	37	6	4032325	4032325	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr6:4032325A>G	ENST00000337659.6	+	2	674	c.574A>G	c.(574-576)Act>Gct	p.T192A	PRPF4B_ENST00000538861.1_Missense_Mutation_p.T178A	NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	192	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CAAAGAACGGACTAGACATAG	0.353000													6	127					0	0	1	0	0
AC018737.1	0	broad.mit.edu	37	2	122466739	122466739	+	RNA	DEL	G	G	-	rs6733674	by1000genomes	TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr2:122466739delG	ENST00000419902.1	+	0	637					NR_037857.1																						tttttttgttgtttttttttt	0.458													4	5	---	---	---	---					
COL6A6	131873	broad.mit.edu	37	3	130394186	130394186	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr3:130394186delC	ENST00000358511.6	+	36	6768	c.6737delC	c.(6736-6738)tcfs	p.S2246fs	COL6A6_ENST00000453409.2_Frame_Shift_Del_p.S2246fs	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	2246	Nonhelical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						AGAAGCACCTCCCATACCTTT	0.348													2	4	---	---	---	---					
CCT6P1	0	broad.mit.edu	37	7	65226819	65226819	+	RNA	DEL	A	A	-			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr7:65226819delA	ENST00000442266.1	+	0	1167																											AATGGGGACCAAAAAAAAAAT	0.353													2	4	---	---	---	---					
NUTM2F	54754	broad.mit.edu	37	9	97080945	97080947	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr9:97080945_97080947delAGA	ENST00000253262.4	-	7	2091_2093	c.2071_2073delTCT	c.(2071-2073)del	p.S691del	NUTM2F_ENST00000335456.7_Intron|NUTM2F_ENST00000341207.4_In_Frame_Del_p.S676del	NM_017561.1	NP_060031.1			NUT family member 2F									p.S557delS(1)									TGCTGGCAGGAGAAGGTGATGGG	0.611													4	2	---	---	---	---					
EMG1	10436	broad.mit.edu	37	12	7080210	7080211	+	RNA	INS	-	-	G	rs141646579	by1000genomes	TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr12:7080210_7080211insG	ENST00000546220.1	+	0	155_156				U47924.19_ENST00000564245.1_RNA|U47924.28_ENST00000261406.6_lincRNA			Q92979	NEP1_HUMAN	EMG1 N1-specific pseudouridine methyltransferase						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding										CGGAGGCCGTAGTTTATTGTGG	0.569													4	9	---	---	---	---					
NLRC3	197358	broad.mit.edu	37	16	3594163	3594163	+	RNA	DEL	A	A	-	rs60164526		TCGA-EM-A3SU-01A-11D-A22Z-08	TCGA-EM-A3SU-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	598f5833-ab0a-4167-9c12-80573a106ea8	1ef6114a-a3ca-4992-9510-4209bfd07727	g.chr16:3594163delA	ENST00000301749.7	-	0	3261				NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000359128.5_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						tgtctcgaggaaaaaaaaaaa	0.488													2	4	---	---	---	---					
