Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DEGS2	123099	broad.mit.edu	37	14	100615601	100615601	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr14:100615601C>T	ENST00000305631.5	-	2	1104	c.529G>A	c.(529-531)Gtc>Atc	p.V177I	DEGS2_ENST00000557117.1_5'UTR|DEGS2_ENST00000553834.1_Intron	NM_206918.2	NP_996801.2	Q6QHC5	DEGS2_HUMAN	delta(4)-desaturase, sphingolipid 2	177					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity			breast(1)|lung(6)|skin(1)	8		Melanoma(154;0.212)				TTGGGGTGGACGCAGAGCGGC	0.667000													10	32					0	0	1	0	0
UBAP1	51271	broad.mit.edu	37	9	34241443	34241443	+	Silent	SNP	G	G	A			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr9:34241443G>A	ENST00000536252.1	+	5	818	c.420G>A	c.(418-420)acG>acA	p.T140T	UBAP1_ENST00000379186.4_Silent_p.T140T|UBAP1_ENST00000297661.4_Silent_p.T140T|UBAP1_ENST00000545103.1_Silent_p.T204T|UBAP1_ENST00000543944.1_Silent_p.T176T|UBAP1_ENST00000359544.2_Silent_p.T140T|UBAP1_ENST00000540348.1_Silent_p.T140T	NM_001171203.2	NP_001164674.1	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	140						cytoplasm				endometrium(4)|kidney(2)|lung(6)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(29;0.00272)			GTAGTGCCACGAAACAGAAAG	0.478000													9	58					0	0	1	0	0
ANKRD20A11P	0	broad.mit.edu	37	21	15326405	15326405	+	RNA	SNP	C	C	T	rs8127713	by1000genomes	TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr21:15326405C>T	ENST00000344693.5	-	0	802					NR_027270.1																						TTTCCATTGACTATTCTGTTT	0.423000													5	87					0	0	1	0	0
RNF10	9921	broad.mit.edu	37	12	121001322	121001322	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr12:121001322A>G	ENST00000325954.4	+	9	1888	c.1427A>G	c.(1426-1428)aAt>aGt	p.N476S	RNF10_ENST00000413266.2_Missense_Mutation_p.N481S	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	476					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCAGATGACAATCTTAAAGAG	0.527000													11	41					0	0	1	0	0
OTUD5	55593	broad.mit.edu	37	X	48781191	48781191	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chrX:48781191T>C	ENST00000156084.4	-	7	1477	c.1417A>G	c.(1417-1419)Atg>Gtg	p.M473V	OTUD5_ENST00000428668.2_Missense_Mutation_p.M251V|OTUD5_ENST00000396743.3_Missense_Mutation_p.M468V|OTUD5_ENST00000376488.3_Missense_Mutation_p.M468V	NM_017602.3	NP_060072.1	Q96G74	OTUD5_HUMAN	OTU domain containing 5	473					negative regulation of type I interferon production		cysteine-type peptidase activity			endometrium(2)|large_intestine(3)|lung(6)|pancreas(2)	13						GGGGGCTTCATGCCCAATTCA	0.617000													5	17					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70417314	70417314	+	Silent	SNP	G	G	A	rs144601570	byFrequency	TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr18:70417314G>A	ENST00000327305.6	-	9	2181	c.1524C>T	c.(1522-1524)caC>caT	p.H508H	NETO1_ENST00000583169.1_Silent_p.H508H|NETO1_ENST00000299430.2_Silent_p.H507H	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	508					memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CGGCTTTATCGTGTCTGGACA	0.438000													7	37					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34233869	34233869	+	RNA	SNP	G	G	T			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr17:34233869G>T	ENST00000587132.1	-	0	4158																											GCAAATCTCAGTGTTGAACTT	0.522000													4	24					0.00909568	0.00909568	1	1	0
PTPRD	5789	broad.mit.edu	37	9	8375990	8375990	+	Missense_Mutation	SNP	C	C	T	rs142960593	byFrequency	TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr9:8375990C>T	ENST00000381196.4	-	36	5150	c.4607G>A	c.(4606-4608)cGt>cAt	p.R1536H	PTPRD_ENST00000397611.3_Missense_Mutation_p.R1126H|PTPRD_ENST00000397617.3_Missense_Mutation_p.R1129H|PTPRD_ENST00000540109.1_Missense_Mutation_p.R1536H|PTPRD_ENST00000360074.4_Missense_Mutation_p.R1523H|PTPRD_ENST00000537002.1_Missense_Mutation_p.R1126H|PTPRD_ENST00000358503.5_Missense_Mutation_p.R1514H|PTPRD_ENST00000486161.1_Missense_Mutation_p.R1129H|PTPRD_ENST00000356435.5_Missense_Mutation_p.R1536H|PTPRD_ENST00000355233.5_Missense_Mutation_p.R1130H|PTPRD_ENST00000397606.3_Missense_Mutation_p.R1129H	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1536	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.R1536L(1)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTTGACTCTACGTAAGAAAGC	0.468000										TSP Lung(15;0.13)			13	56					0	0	1	0	0
ENTPD6	0	broad.mit.edu	37	20	25198164	25198164	+	Silent	SNP	C	C	T			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr20:25198164C>T	ENST00000360031.2	+	9	1004	c.822C>T	c.(820-822)ggC>ggT	p.G274G	ENTPD6_ENST00000433259.2_Silent_p.G275G|ENTPD6_ENST00000376652.4_Silent_p.G275G|ENTPD6_ENST00000354989.5_Silent_p.G258G	NM_001247.2	NP_001238.2	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6 (putative)	275						Golgi membrane|integral to membrane	nucleoside-diphosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|prostate(1)|skin(1)	27						CCCCACCCGGCTACCTGACGG	0.552000													14	83					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160523156	160523156	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr1:160523156G>A	ENST00000311224.4	-	4	838	c.772C>T	c.(772-774)Cca>Tca	p.P258S	CD84_ENST00000368051.3_Intron|CD84_ENST00000534968.1_Intron|CD84_ENST00000368054.3_Intron|CD84_ENST00000368048.3_Intron|RP11-528G1.2_ENST00000446952.1_RNA	NM_001184879.1	NP_001171808.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	258					blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TTACCTTCTGGGAAAATCCTA	0.458000													7	37					0	0	1	0	0
BSG	682	broad.mit.edu	37	19	577919	577919	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr19:577919G>C	ENST00000333511.3	+	2	283	c.213G>C	c.(211-213)tgG>tgC	p.W71C	BSG_ENST00000545507.2_Intron|BSG_ENST00000353555.4_Intron|BSG_ENST00000346916.4_Intron|BSG_ENST00000574970.1_3'UTR	NM_001728.3	NP_001719.2	P35613	BASI_HUMAN	basigin	71					blood coagulation|cell surface receptor linked signaling pathway|leukocyte migration|pyruvate metabolic process	Golgi membrane|integral to membrane|melanosome	lactate transmembrane transporter activity|mannose binding|protein binding			central_nervous_system(1)|endometrium(3)|lung(1)	5		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGCTCTGGGACGGCGCCC	0.687000													4	13					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99119209	99119209	+	Missense_Mutation	SNP	T	T	C	rs138188210	byFrequency	TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr12:99119209T>C	ENST00000357310.1	+	24	3795	c.3218T>C	c.(3217-3219)cTc>cCc	p.L1073P	APAF1_ENST00000552268.1_Intron|APAF1_ENST00000359972.2_Missense_Mutation_p.L1062P|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000547045.1_Missense_Mutation_p.L1073P|APAF1_ENST00000551964.1_Missense_Mutation_p.L1116P|APAF1_ENST00000339433.3_Intron|APAF1_ENST00000550527.1_Missense_Mutation_p.L1105P|APAF1_ENST00000549007.1_Intron	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	1116					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	AGTTTTGATCTCCTTTTGCCA	0.458000													4	73					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													3	37					0	0	1	0	0
NDUFAF2	91942	broad.mit.edu	37	5	60241050	60241050	+	Translation_Start_Site	SNP	G	G	A			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr5:60241050G>A	ENST00000296597.5	+	0	95				NDUFAF2_ENST00000511107.1_De_novo_Start_OutOfFrame	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2							membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				TGCGGGTCCCGCTGCTGGCAG	0.632000													3	16					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111556600	111556600	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr2:111556600G>C	ENST00000389811.4	+	7	694	c.470G>C	c.(469-471)tGt>tCt	p.C157S	ACOXL_ENST00000439055.1_Missense_Mutation_p.C157S|ACOXL_ENST00000340561.4_Missense_Mutation_p.C157S			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	157					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						GGGCCCCACTGTTTCATCGTT	0.463000													13	107					0	0	1	0	0
STAG3L4	0	broad.mit.edu	37	7	66774113	66774113	+	RNA	SNP	T	T	C			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr7:66774113T>C	ENST00000416602.2	+	0	554					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				TCTGTCACACTAGCACCCTGG	0.498000													13	69					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599357	136599357	+	Missense_Mutation	SNP	T	T	A			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr6:136599357T>A	ENST00000531224.1	-	4	914	c.662A>T	c.(661-663)aAt>aTt	p.N221I	BCLAF1_ENST00000527759.1_Missense_Mutation_p.N219I|BCLAF1_ENST00000527536.1_Missense_Mutation_p.N221I|BCLAF1_ENST00000530767.1_Missense_Mutation_p.N221I|BCLAF1_ENST00000392348.2_Missense_Mutation_p.N219I|BCLAF1_ENST00000353331.4_Missense_Mutation_p.N219I	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	221					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCTAGGACTATTATCATAAGC	0.433000													10	175					0	0	1	0	0
IGHV4-4	0	broad.mit.edu	37	14	106478464	106478464	+	RNA	SNP	T	T	C	rs80132192		TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr14:106478464T>C	ENST00000390596.2	-	0	110																											ACCTCCCATATCCCCATGTCT	0.587000													4	55					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306946	2306946	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr4:2306946C>G	ENST00000290974.2	-	8	1460	c.1121G>C	c.(1120-1122)gGa>gCa	p.G374A	ZFYVE28_ENST00000515312.1_Missense_Mutation_p.G304A|ZFYVE28_ENST00000511071.1_Missense_Mutation_p.G344A|RP11-478C1.7_ENST00000510632.1_RNA	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	374					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GCCCTCCGCTCCTGGCCTGTG	0.667000													9	40					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160109744	160109744	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr1:160109744C>T	ENST00000361216.3	+	22	3093	c.3004C>T	c.(3004-3006)Cga>Tga	p.R1002*	ATP1A2_ENST00000392233.3_Nonsense_Mutation_p.R991*	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	1002					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity	p.R1002R(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGATGAGGTCCGAAAGCTCAT	0.582000													10	69					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152665261	152665261	+	Missense_Mutation	SNP	C	C	A	rs4645434	byFrequency	TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr6:152665261C>A	ENST00000367255.5	-	74	12781	c.12180G>T	c.(12178-12180)gaG>gaT	p.E4060D	SYNE1_ENST00000448038.1_Missense_Mutation_p.E3989D|SYNE1_ENST00000341594.5_Missense_Mutation_p.E3925D|SYNE1_ENST00000423061.1_Missense_Mutation_p.E3989D|SYNE1_ENST00000265368.4_Missense_Mutation_p.E4060D	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4060			E -> D (in dbSNP:rs4645434).		cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.E4060D(3)		NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAGGACTTGGCTCTAAATCCG	0.498000										HNSCC(10;0.0054)			4	69					0.00909568	0.00909568	1	1	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				16	63					0	0	1	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													5	38					0	0	1	0	0
AMZ2P1	0	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													6	111					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8639291	8639291	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr20:8639291C>A	ENST00000378641.3	+	9	1277	c.802C>A	c.(802-804)Caa>Aaa	p.Q268K	PLCB1_ENST00000378637.2_Missense_Mutation_p.Q268K|PLCB1_ENST00000338037.6_Missense_Mutation_p.Q268K	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	268					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						ACCTCTAAAACAAGAGCAAGT	0.398000													17	92					3.52763e-06	3.71831e-06	1	1	0
TMSB15A	11013	broad.mit.edu	37	X	101770063	101770063	+	Missense_Mutation	SNP	A	A	T			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chrX:101770063A>T	ENST00000289373.4	-	2	164	c.29T>A	c.(28-30)gTg>gAg	p.V10E		NM_021992.2	NP_068832.1	P0CG34	TB15A_HUMAN	thymosin beta 15a	10					actin cytoskeleton organization|sequestering of actin monomers	cytoplasm|cytoskeleton	actin binding			large_intestine(1)|lung(1)	2						AAACTTCTCCACTTCCGACAA	0.383000													15	34					0	0	1	0	0
INTS4L2	0	broad.mit.edu	37	7	65150824	65150825	+	RNA	INS	-	-	G			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr7:65150824_65150825insG	ENST00000430126.2	+	0	757																											TCACCCCCCCCCCCGTTAAAAT	0.470													2	4	---	---	---	---					
AC005077.5	0	broad.mit.edu	37	7	75804673	75804673	+	RNA	DEL	A	A	-			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr7:75804673delA	ENST00000437494.1	+	0	57																											atctcgaaccaaaaaaaaaag	0.542													2	4	---	---	---	---					
UBE2Q2P1	0	broad.mit.edu	37	15	85077360	85077360	+	RNA	DEL	A	A	-			TCGA-EM-A4FO-01A-11D-A257-08	TCGA-EM-A4FO-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebe8c430-5f66-4ddc-bbfb-30a601278c1f	059e7e1a-05de-45bb-879b-d3a813025b91	g.chr15:85077360delA	ENST00000339094.1	-	0	1678					NR_003661.2																						tttttaaactaaaaaaaaaaa	0.373													5	8	---	---	---	---					
