Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													4	149					0	0	0.000248	0	0
SVIL	6840	broad.mit.edu	37	10	29769508	29769508	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr10:29769508C>A	ENST00000375398.2	-	31	5784	c.5335G>T	c.(5335-5337)Gat>Tat	p.D1779Y	SVIL_ENST00000355867.4_Missense_Mutation_p.D1779Y|PTCHD3P1_ENST00000446807.1_RNA|PTCHD3P1_ENST00000414457.1_RNA|PTCHD3P1_ENST00000413405.1_RNA|SVIL_ENST00000538146.1_Missense_Mutation_p.D571Y|PTCHD3P1_ENST00000423223.1_RNA|SVIL_ENST00000535393.1_Missense_Mutation_p.D693Y|SVIL_ENST00000375400.3_Missense_Mutation_p.D1353Y|SVIL_ENST00000460007.1_5'UTR			O95425	SVIL_HUMAN	supervillin	1779					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				ACATAGGCATCCCCCTCATGG	0.557000													29	46					3.80469e-20	8.48739e-20	0.001786	1	0
FAM153A	285596	broad.mit.edu	37	5	177161894	177161894	+	Missense_Mutation	SNP	G	G	T			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr5:177161894G>T	ENST00000440605.3	-	12	757	c.474C>A	c.(472-474)aaC>aaA	p.N158K	FAM153A_ENST00000510276.1_Missense_Mutation_p.N158K|FAM153A_ENST00000393518.3_Intron|FAM153A_ENST00000513554.1_Intron	NM_173663.3	NP_775934.3	Q9UHL3	F153A_HUMAN	family with sequence similarity 153, member A	158										kidney(6)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|stomach(1)	11	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTCCTCACCGTTGTAACTGG	0.443000													7	15					0.000274275	0.000589184	0.004482	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274291	39274291	+	Missense_Mutation	SNP	T	T	C	rs149439944	by1000genomes	TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr17:39274291T>C	ENST00000391413.2	-	1	315	c.277A>G	c.(277-279)Atg>Gtg	p.M93V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	93	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.M93V(4)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCAGCACATAGACTGGCAG	0.662000													3	69					0	0	0.000602	0	0
WIPF1	7456	broad.mit.edu	37	2	175436655	175436655	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr2:175436655G>A	ENST00000392547.2	-	5	977	c.878C>T	c.(877-879)cCa>cTa	p.P293L	WIPF1_ENST00000409415.3_Missense_Mutation_p.P293L|AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000272746.5_Missense_Mutation_p.P293L|WIPF1_ENST00000409891.1_Missense_Mutation_p.P293L|WIPF1_ENST00000359761.3_Missense_Mutation_p.P293L|WIPF1_ENST00000392546.2_Missense_Mutation_p.P293L|AC018890.6_ENST00000412835.1_RNA	NM_003387.4	NP_003378.3	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	293	Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						GGAAGGCACTGGAGGCTTGTT	0.672000													3	22					0	0	0.000602	0	0
ASB10	136371	broad.mit.edu	37	7	150878358	150878358	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr7:150878358C>T	ENST00000422024.1	-	3	1032	c.907G>A	c.(907-909)Gtc>Atc	p.V303I	ASB10_ENST00000275838.1_Missense_Mutation_p.V258I|ASB10_ENST00000420175.2_Missense_Mutation_p.V258I|ASB10_ENST00000434669.1_Missense_Mutation_p.V303I|ASB10_ENST00000377867.3_Missense_Mutation_p.V243I	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	258					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGCAGCGGACGTCACAGGCA	0.647000													7	19					0	0	0.003080	0	0
UBE2F	140739	broad.mit.edu	37	2	238939226	238939226	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr2:238939226C>T	ENST00000272930.4	+	7	577	c.383C>T	c.(382-384)aCt>aTt	p.T128I	UBE2F_ENST00000409953.1_Missense_Mutation_p.T104I|UBE2F_ENST00000409633.1_Missense_Mutation_p.T128I|UBE2F-SCLY_ENST00000449191.1_Intron|UBE2F_ENST00000409332.1_Missense_Mutation_p.T106I|UBE2F_ENST00000414443.1_Missense_Mutation_p.T96I	NM_001278305.1|NM_080678.2	NP_001265234.1|NP_542409.1	Q969M7	UBE2F_HUMAN	ubiquitin-conjugating enzyme E2F (putative)	128					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding			endometrium(1)|large_intestine(1)	2		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;6.7e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|Kidney(56;3.53e-09)|KIRC - Kidney renal clear cell carcinoma(57;9.79e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000136)|Lung(119;0.0126)|LUSC - Lung squamous cell carcinoma(224;0.0301)		ATTGATGGCACTGGCTGGGCT	0.502000													8	18					0	0	0.004482	0	0
FLNA	0	broad.mit.edu	37	X	153585851	153585851	+	Silent	SNP	G	G	A			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chrX:153585851G>A	ENST00000422373.1	-	29	5144	c.4896C>T	c.(4894-4896)taC>taT	p.Y1632Y	FLNA_ENST00000369856.3_5'UTR|FLNA_ENST00000360319.4_Silent_p.Y1632Y|FLNA_ENST00000369850.3_Silent_p.Y1632Y|FLNA_ENST00000344736.4_Silent_p.Y1632Y	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1632					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CACGCACGCGGTACGGGGAGA	0.657000													3	43					0	0	0.004672	0	0
IL2RA	3559	broad.mit.edu	37	10	6061871	6061871	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr10:6061871C>T	ENST00000379959.3	-	5	790	c.617G>A	c.(616-618)cGt>cAt	p.R206H	IL2RA_ENST00000256876.6_Missense_Mutation_p.R197H|IL2RA_ENST00000379954.1_Missense_Mutation_p.R134H	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	206					cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	ACTCTCAGGACGGCCTTCGGG	0.597000													4	85					0	0	0.000602	0	0
FAM153B	202134	broad.mit.edu	37	5	175530270	175530270	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr5:175530270C>A	ENST00000253490.4	+	13	762	c.705C>A	c.(703-705)aaC>aaA	p.N235K	FAM153B_ENST00000515817.1_Missense_Mutation_p.N158K|FAM153B_ENST00000512862.1_Intron|FAM153B_ENST00000510151.1_Missense_Mutation_p.N158K			P0C7A2	F153B_HUMAN	family with sequence similarity 153, member B	235										endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	16	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		CCAGTTACAACGGCGAGGAGG	0.448000													58	271					1.48005e-37	3.43371e-37	0.003610	1	0
ARHGEF40	55701	broad.mit.edu	37	14	21542856	21542856	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr14:21542856G>A	ENST00000298694.4	+	3	1094	c.967G>A	c.(967-969)Gag>Aag	p.E323K	ARHGEF40_ENST00000298693.3_Missense_Mutation_p.E323K			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	323	Gly-rich.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						CCCAGGAGCTGAGGCTGTCCC	0.692000													4	10					0	0	0.000248	0	0
YDJC	150223	broad.mit.edu	37	22	21982797	21982797	+	Silent	SNP	G	G	A			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr22:21982797G>A	ENST00000292778.6	-	5	931	c.882C>T	c.(880-882)tgC>tgT	p.C294C	YDJC_ENST00000398873.3_3'UTR	NM_001017964.1	NP_001017964.1	A8MPS7	YDJC_HUMAN	YdjC homolog (bacterial)	294					carbohydrate metabolic process		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds					Colorectal(54;0.105)					CGTCGAGGGCGCAAAGCTGCA	0.667000													4	54					0	0	0.000248	0	0
SLC8A1	6546	broad.mit.edu	37	2	40342407	40342407	+	Missense_Mutation	SNP	T	T	C			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr2:40342407T>C	ENST00000406785.1	-	8	2989	c.2800A>G	c.(2800-2802)Ata>Gta	p.I934V	SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1_ENST00000402441.1_Missense_Mutation_p.I934V|SLC8A1_ENST00000542024.1_Missense_Mutation_p.I934V|SLC8A1_ENST00000542756.1_Missense_Mutation_p.I965V|SLC8A1_ENST00000408028.2_Missense_Mutation_p.I962V|SLC8A1_ENST00000332839.4_Missense_Mutation_p.I970V|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1_ENST00000406391.2_Missense_Mutation_p.I934V|SLC8A1_ENST00000405901.3_Missense_Mutation_p.I965V|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1_ENST00000405269.1_Missense_Mutation_p.I934V|SLC8A1_ENST00000403092.1_Missense_Mutation_p.I970V|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	970					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AAGCCTTTTATGTGGCAGTAG	0.408000													3	57					0	0	0.004672	0	0
VAV3	10451	broad.mit.edu	37	1	108292102	108292102	+	Silent	SNP	G	G	A	rs143070546	by1000genomes	TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr1:108292102G>A	ENST00000370056.4	-	14	1648	c.1374C>T	c.(1372-1374)acC>acT	p.T458T	VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000371846.4_Silent_p.T393T|VAV3_ENST00000527011.1_Silent_p.T458T	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	458	PH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TTTCTTTATCGGTTGTAGGAT	0.294000													9	42					0	0	0.006214	0	0
MAPK10	5602	broad.mit.edu	37	4	87028402	87028402	+	Missense_Mutation	SNP	G	G	C			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr4:87028402G>C	ENST00000395169.3	-	5	946	c.226C>G	c.(226-228)Ctc>Gtc	p.L76V	MAPK10_ENST00000395157.3_5'UTR|MAPK10_ENST00000359221.3_Missense_Mutation_p.L114V|MAPK10_ENST00000395166.1_Missense_Mutation_p.L76V|MAPK10_ENST00000513839.1_5'UTR|MAPK10_ENST00000395161.2_Missense_Mutation_p.L114V|MAPK10_ENST00000395160.3_5'UTR|MAPK10_ENST00000361569.2_Missense_Mutation_p.L114V|MAPK10_ENST00000449047.2_5'UTR	NM_138980.2|NM_138982.2	NP_620446.1|NP_620448.1	P53779	MK10_HUMAN	mitogen-activated protein kinase 10	114	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		CACTTCATGAGGACCAGCTCC	0.433000													3	75					0	0	0.000602	0	0
CCDC39	339829	broad.mit.edu	37	3	180381735	180381735	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr3:180381735C>T	ENST00000273654.4	-	8	1001	c.382G>A	c.(382-384)Gag>Aag	p.E128K	CCDC39_ENST00000442201.2_Missense_Mutation_p.E44K			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	44					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TCACGTAACTCATCTTGCAAG	0.333000													9	65					0	0	0.004482	0	0
MRFAP1L1	114932	broad.mit.edu	37	4	6711139	6711139	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr4:6711139G>A	ENST00000320848.6	-	1	468	c.218C>T	c.(217-219)gCc>gTc	p.A73V		NM_203462.2	NP_982287.1	Q96HT8	MR1L1_HUMAN	Morf4 family associated protein 1-like 1	73																	CTCCTCCGAGGCCTCCACCTG	0.602000													6	162					0	0	0.001168	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr6:29910607G>C	ENST00000396634.1	+	4	488	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-A_ENST00000376802.2_Silent_p.V49V|HLA-A_ENST00000376806.5_Silent_p.V49V|HLA-A_ENST00000376809.5_Silent_p.V49V			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.V49V(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			4	39					0	0	0.000248	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162379	90162379	+	RNA	SNP	A	A	G			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr16:90162379A>G	ENST00000564451.1	+	0	1732				TUBB8P7_ENST00000567960.1_RNA																							TGGGAATAATACGGCCATCCA	0.522000													3	123					0	0	0.004672	0	0
B3GNTL1	146712	broad.mit.edu	37	17	80923589	80923589	+	Missense_Mutation	SNP	G	G	C			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr17:80923589G>C	ENST00000576599.1	-	7	955	c.205C>G	c.(205-207)Ccc>Gcc	p.P69A	B3GNTL1_ENST00000320865.3_Missense_Mutation_p.P180A|B3GNTL1_ENST00000571954.1_5'UTR			Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	180							transferase activity, transferring glycosyl groups			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	8	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			AACCAGGTGGGCATGATCACC	0.552000													10	12					0	0	0.003163	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				39	56					0	0	0.008740	0	0
ARMCX1	51309	broad.mit.edu	37	X	100808364	100808364	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chrX:100808364G>A	ENST00000372829.3	+	4	822	c.451G>A	c.(451-453)Ggc>Agc	p.G151S		NM_016608.1	NP_057692.1	Q9P291	ARMX1_HUMAN	armadillo repeat containing, X-linked 1	151						integral to membrane	binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(2)|ovary(3)|pancreas(1)|urinary_tract(1)	19						CAGGGGTGGAGGCTGCCACCC	0.617000													4	141					0	0	0.000248	0	0
RP11-206L10.2	0	broad.mit.edu	37	1	700532	700532	+	RNA	DEL	T	T	-			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr1:700532delT	ENST00000428504.1	-	0	1021					NR_033908.1																						aaaaaaaaaaTTCCTTTGGGA	0.453													2	4	---	---	---	---					
CASP8AP2	9994	broad.mit.edu	37	6	90556397	90556398	+	RNA	INS	-	-	T			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr6:90556397_90556398insT	ENST00000551025.1	+	0	1492							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TTCTAAtttccttttttttttt	0.421													4	6	---	---	---	---					
RP11-274B21.1	0	broad.mit.edu	37	7	128210235	128210237	+	RNA	DEL	TTT	TTT	-			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr7:128210235_128210237delTTT	ENST00000605862.1	+	0	189																											gttttagttcttTTTTTTTTTTT	0.438													3	3	---	---	---	---					
COMTD1	118881	broad.mit.edu	37	10	76994748	76994748	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr10:76994748delG	ENST00000372538.3	-	5	532	c.450delC	c.(448-450)gcfs	p.A150fs	COMTD1_ENST00000460899.1_5'UTR	NM_144589.2	NP_653190.2	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing 1	150						integral to membrane	O-methyltransferase activity			central_nervous_system(1)|large_intestine(1)|lung(1)	3	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					GCTCCGCCTCGGCCTGCGGAG	0.697													2	4	---	---	---	---					
INPP5F	22876	broad.mit.edu	37	10	121586793	121586794	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-ET-A3BQ-01B-11D-A202-08	TCGA-ET-A3BQ-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b7a5a3f-8a69-4a00-b546-54b01a0a6cb4	ed9c6a96-923e-4d15-a6a8-5579a37b2a75	g.chr10:121586793_121586794delCA	ENST00000361976.2	+	20	3066_3067	c.2900_2901delCA	c.(2899-2901)gfs	p.A967fs	INPP5F_ENST00000369080.3_Frame_Shift_Del_p.A357fs	NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	967							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		GTGCAAGATGCACAGAACAAAG	0.436													11	75	---	---	---	---					
