Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RYR1	6261	broad.mit.edu	37	19	38993288	38993288	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr19:38993288G>A	ENST00000355481.4	+	48	7887	c.7756G>A	c.(7756-7758)Gtg>Atg	p.V2586M	RYR1_ENST00000359596.3_Missense_Mutation_p.V2586M|RYR1_ENST00000360985.3_Missense_Mutation_p.V2586M	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2586	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCTGCATACCGTGTACCGCCT	0.637000													3	43					0	0	0.150653	0	0
POM121L9P	0	broad.mit.edu	37	22	24659593	24659593	+	RNA	SNP	C	C	T			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr22:24659593C>T	ENST00000414583.2	+	0	3118					NR_003714.1																						TCACTGACATCGAAGGCTGCC	0.632000													4	18					0	0	0.307466	0	0
FAM86C1	55199	broad.mit.edu	37	11	71502813	71502813	+	Missense_Mutation	SNP	A	A	C			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr11:71502813A>C	ENST00000426628.2	+	3	207	c.188A>C	c.(187-189)cAc>cCc	p.H63P	FAM86C1_ENST00000359244.4_Intron|FAM86C1_ENST00000528685.1_Intron|FAM86C1_ENST00000346333.6_Intron	NM_001099653.1	NP_001093123.1	Q9NVL1	FA86C_HUMAN	family with sequence similarity 86, member C1	60								p.H63P(1)		lung(1)	1						TGTGTGAAGCACCCGCCGTCA	0.532000													4	39					0	0	0.278610	0	0
POM121L9P	0	broad.mit.edu	37	22	24659591	24659591	+	RNA	SNP	A	A	G			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr22:24659591A>G	ENST00000414583.2	+	0	3116					NR_003714.1																						ACTCACTGACATCGAAGGCTG	0.632000													3	20					0	0	0.248553	0	0
KLHL14	57565	broad.mit.edu	37	18	30350455	30350455	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr18:30350455C>A	ENST00000359358.4	-	2	538	c.100G>T	c.(100-102)Gac>Tac	p.D34Y	KLHL14_ENST00000358095.4_Missense_Mutation_p.D34Y|AC012123.1_ENST00000426194.1_Intron	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	34	BTB.					cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						AGGGTCACGTCGCAAAACAGC	0.642000													13	47					5.50884e-06	6.6106e-06	0.411799	1	0
TPTE2P6	0	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													5	41					0	0	0.278610	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													4	35					0	0	0.150653	0	0
CITED2	10370	broad.mit.edu	37	6	139694455	139694455	+	Silent	SNP	G	G	T			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr6:139694455G>T	ENST00000367651.2	-	2	842	c.627C>A	c.(625-627)ccC>ccA	p.P209P	CITED2_ENST00000536159.1_Silent_p.P209P|CITED2_ENST00000537332.1_Silent_p.P209P	NM_006079.4	NP_006070.2	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	209					adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)|lung(4)	5	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		GCATTGCAGCGGGGACGTGGG	0.647000													12	84					0.000151284	0.000172897	0.435327	1	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													5	35					0	0	0.184627	0	0
CASP7	840	broad.mit.edu	37	10	115481474	115481474	+	Silent	SNP	G	G	T			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr10:115481474G>T	ENST00000369321.2	+	5	731	c.411G>T	c.(409-411)ctG>ctT	p.L137L	CASP7_ENST00000369331.4_Silent_p.L104L|CASP7_ENST00000369315.1_Silent_p.L104L|CASP7_ENST00000452490.2_Silent_p.L79L|CASP7_ENST00000345633.4_Silent_p.L104L|CASP7_ENST00000369318.3_Silent_p.L104L	NM_033338.5	NP_203124.1	P55210	CASP7_HUMAN	caspase 7, apoptosis-related cysteine peptidase	104					activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis	cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm	cysteine-type endopeptidase activity|protein binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)	8		Colorectal(252;0.0946)|Breast(234;0.188)		Epithelial(162;0.012)|all cancers(201;0.014)		TCCGAAGCCTGGGTTTTGACG	0.498000													21	115					3.5997e-14	4.54699e-14	0.624587	1	0
ZDHHC8	29801	broad.mit.edu	37	22	20130550	20130550	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr22:20130550C>T	ENST00000334554.7	+	10	1538	c.1397C>T	c.(1396-1398)gCc>gTc	p.A466V	ZDHHC8_ENST00000405930.3_Missense_Mutation_p.A466V|ZDHHC8_ENST00000320602.7_Missense_Mutation_p.A374V	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	466						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					AGCATTTTTGCCCCCCATGCA	0.697000													3	41					0	0	0.115264	0	0
ZMYND15	84225	broad.mit.edu	37	17	4643964	4643964	+	Silent	SNP	C	C	A			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr17:4643964C>A	ENST00000433935.1	+	2	178	c.121C>A	c.(121-123)Cgg>Agg	p.R41R	ZMYND15_ENST00000269289.6_Silent_p.R41R|ZMYND15_ENST00000592813.1_Silent_p.R41R|ZMYND15_ENST00000573751.2_Silent_p.R41R	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	41							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						GGGCCGCTGCCGGCAGCTGGA	0.612000													3	39					0.115264	0.125743	0.115264	1	0
OTOP1	133060	broad.mit.edu	37	4	4228274	4228282	+	In_Frame_Del	DEL	CCACAGCAG	CCACAGCAG	-	rs111245977		TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr4:4228274_4228282delCCACAGCAG	ENST00000296358.4	-	1	334_342	c.310_318delCTGCTGTGG	c.(310-318)del	p.LLW104del		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	104					biomineral tissue development	extracellular space|integral to membrane		p.L104_W106delLLW(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACCACAGCATCCACAGCAGCTGCAGCAGC	0.727													8	21	---	---	---	---					
TSKU	25987	broad.mit.edu	37	11	76506673	76506675	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr11:76506673_76506675delCTG	ENST00000527881.1	+	2	1039_1041	c.13_15delCTG	c.(13-15)del	p.L9del	TSKU_ENST00000333090.4_In_Frame_Del_p.L9del			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	9						extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					GCCGTGGCCCCTGCTGCTGCTGC	0.616													7	68	---	---	---	---					
FSCB	84075	broad.mit.edu	37	14	44974154	44974155	+	In_Frame_Ins	INS	-	-	GGGGCCTCCTCAGCTGGTGGAGGCTGAACTTCAGAG	rs71108655	byFrequency	TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr14:44974154_44974155insGGGGCCTCCTCAGCTGGTGGAGGCTGAACTTCAGAG	ENST00000340446.4	-	1	2327_2328	c.2036_2037insCTCTGAAGTTCAGCCTCCACCAGCTGAGGAGGCCCC	c.(2035-2037)cgc>cCTCTGAAGTTCAGCCTCCACCAGCTGAGGAGGCCCCgc	p.678_679insPLKFSLHQLRRP		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	678	Ala-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		GAACTTCAGCAGGGGCCTCCTC	0.604													7	27	---	---	---	---					
AC008103.5	0	broad.mit.edu	37	22	18843723	18843724	+	RNA	INS	-	-	A			TCGA-ET-A3DQ-01A-11D-A19J-08	TCGA-ET-A3DQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d911ad12-c0cf-485b-acb4-13ce9e0385ea	c77ff260-24f6-413f-9bed-4f2975f54f41	g.chr22:18843723_18843724insA	ENST00000412938.1	+	0	2337																											AGGGGCACCCCACGGCCTGGAG	0.619													2	4	---	---	---	---					
