Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-24M17.5	0	broad.mit.edu	37	15	76075458	76075458	+	RNA	SNP	G	G	A			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr15:76075458G>A	ENST00000395215.3	+	0	1098																											GAGAGGCTGCGAAAGCAGGAG	0.607000													8	261					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000583708.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													4	71					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29240059	29240059	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr2:29240059C>T	ENST00000379558.4	+	9	1435	c.1084C>T	c.(1084-1086)Cag>Tag	p.Q362*	FAM179A_ENST00000403861.2_Nonsense_Mutation_p.Q362*|FAM179A_ENST00000465300.1_Intron	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	362			Q -> R (in dbSNP:rs11127202).				binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GGAGAAGATGCAGCTGAAGCA	0.537000													4	101					0	0	1	0	0
FAM66D	0	broad.mit.edu	37	8	11986539	11986539	+	RNA	SNP	G	G	A			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr8:11986539G>A	ENST00000434078.2	+	0	608					NR_027425.1																						GCATTCAAGTGGCAGGTATTT	0.557000													4	90					0	0	1	0	0
ESPNP	0	broad.mit.edu	37	1	17017734	17017734	+	RNA	SNP	C	C	T	rs12561805	by1000genomes	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr1:17017734C>T	ENST00000492551.1	-	0	1993					NR_026567.1																						CAGCTTCTTCCGCAGGAGGTC	0.647000													12	30					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453134	140453134	+	Missense_Mutation	SNP	T	T	C	rs121913377		TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr7:140453134T>C	ENST00000288602.6	-	15	1861	c.1801A>G	c.(1801-1803)Aaa>Gaa	p.K601E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	601	Protein kinase.		K -> E (in colorectal cancer).|K -> Q (in CFC syndrome).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.K601E(40)|p.V600_K601>E(12)|p.T599_R603>I(2)|p.K601del(1)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	CATCGAGATTTCACTGTAGCT	0.368000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				20	42					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31267621	31267621	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr5:31267621G>A	ENST00000265071.2	+	2	306	c.41G>A	c.(40-42)gGc>gAc	p.G14D	CDH6_ENST00000514738.1_5'UTR|RP11-152K4.2_ENST00000523584.1_RNA	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	14					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TTTTGGGTGGGCCAGCCCTAC	0.517000													4	105					0	0	1	0	0
AGFG1	3267	broad.mit.edu	37	2	228399585	228399585	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr2:228399585G>A	ENST00000310078.7	+	8	1309	c.1049G>A	c.(1048-1050)gGg>gAg	p.G350E	AGFG1_ENST00000409979.2_Missense_Mutation_p.G374E|AGFG1_ENST00000409315.1_Intron|AGFG1_ENST00000373671.3_Missense_Mutation_p.G310E|AGFG1_ENST00000409171.1_Missense_Mutation_p.G350E	NM_001135188.1|NM_004504.4	NP_001128660.1|NP_004495.2	P52594	AGFG1_HUMAN	ArfGAP with FG repeats 1	350					cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(2)|ovary(1)|prostate(1)|skin(4)|stomach(1)	18						AGTGGCTTTGGGACCACAGGT	0.438000													14	46					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76074431	76074431	+	RNA	SNP	C	C	T	rs149323153	by1000genomes	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr15:76074431C>T	ENST00000395215.3	+	0	610																		p.S190L(2)									CTCCAGTCCTCGAGCTGCAGA	0.547000													3	26					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95514946	95514946	+	RNA	SNP	C	C	T	rs143937878	by1000genomes	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr2:95514946C>T	ENST00000432432.2	-	0	711					NR_040113.1													p.R201Q(1)									ACTACTGTACCGTCTCAGCCT	0.308000													6	99					0	0	1	0	0
FBXL20	84961	broad.mit.edu	37	17	37455265	37455265	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr17:37455265C>G	ENST00000264658.6	-	5	567	c.307G>C	c.(307-309)Gga>Cga	p.G103R	FBXL20_ENST00000577399.1_Missense_Mutation_p.G105R|FBXL20_ENST00000583610.1_Missense_Mutation_p.G103R|FBXL20_ENST00000394294.3_Missense_Mutation_p.G103R	NM_032875.2	NP_116264.2	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	103						cytoplasm				breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22			LUAD - Lung adenocarcinoma(14;0.146)			TCTCCCACTCCAAGACATCCA	0.403000													18	59					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99119217	99119217	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr12:99119217C>T	ENST00000357310.1	+	24	3803	c.3226C>T	c.(3226-3228)Cca>Tca	p.P1076S	APAF1_ENST00000359972.2_Missense_Mutation_p.P1065S|APAF1_ENST00000547045.1_Missense_Mutation_p.P1076S|APAF1_ENST00000552268.1_Intron|APAF1_ENST00000550527.1_Missense_Mutation_p.P1108S|APAF1_ENST00000549007.1_Intron|APAF1_ENST00000339433.3_Intron|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000551964.1_Missense_Mutation_p.P1119S	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	1119					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	TCTCCTTTTGCCACTTCATGA	0.468000													4	61					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76075478	76075478	+	RNA	SNP	T	T	C			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr15:76075478T>C	ENST00000395215.3	+	0	1118																											GCAGAGGCTATGCAagcagga	0.602000													8	280					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11008888	11008888	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr1:11008888G>A	ENST00000377004.4	-	12	1303	c.1304C>T	c.(1303-1305)cCa>cTa	p.P435L	C1orf127_ENST00000377008.4_Missense_Mutation_p.P268L	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	286										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		TTGCAGGAATGGTCCAAGCCC	0.557000													3	52					0	0	1	0	0
MEN1	0	broad.mit.edu	37	11	64577307	64577307	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr11:64577307C>T	ENST00000337652.1	-	2	778	c.275G>A	c.(274-276)cGc>cAc	p.R92H	MEN1_ENST00000394376.1_Missense_Mutation_p.R92H|MEN1_ENST00000377316.2_Missense_Mutation_p.R92H|MEN1_ENST00000377321.1_Missense_Mutation_p.R92H|MEN1_ENST00000394374.2_Missense_Mutation_p.R92H|MEN1_ENST00000312049.6_Missense_Mutation_p.R92H|MEN1_ENST00000377326.3_Missense_Mutation_p.R92H|MEN1_ENST00000377313.1_Missense_Mutation_p.R92H|MEN1_ENST00000443283.1_Missense_Mutation_p.R92H|MEN1_ENST00000315422.4_Missense_Mutation_p.R92H	NM_130803.2	NP_570715.1	O00255	MEN1_HUMAN	multiple endocrine neoplasia I	92			Missing (in MEN1).		DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding	p.R92fs*26(4)		NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						GGCGGTGAAGCGGGCATAGAG	0.662000			"""D, Mis, N, F, S"""		"""parathyroid tumors, Pancreatic neuroendocrine tumors"""	"""parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"""			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated				3	29					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133899280	133899280	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr8:133899280G>A	ENST00000220616.4	+	9	1703	c.1663G>A	c.(1663-1665)Gaa>Aaa	p.E555K	TG_ENST00000377869.1_Missense_Mutation_p.E555K	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	555					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTTTGGCTTTGAAATTAACCT	0.443000													17	40					0	0	1	0	0
RAB39B	116442	broad.mit.edu	37	X	154490502	154490502	+	Silent	SNP	G	G	A			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chrX:154490502G>A	ENST00000369454.3	-	2	528	c.228C>T	c.(226-228)cgC>cgT	p.R76R		NM_171998.2	NP_741995.1	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	76					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding	p.R76R(1)		breast(1)|central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(12)	19	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGTAGTAGGCGCGAGTGATGG	0.428000													56	140					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31581716	31581716	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr14:31581716C>A	ENST00000399332.1	-	35	6672	c.6184G>T	c.(6184-6186)Gac>Tac	p.D2062Y	HECTD1_ENST00000553700.1_Missense_Mutation_p.D2062Y	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	2062	K-box.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TCACACCAGTCTGGCAGAGCC	0.403000													8	22					0.000274275	0.000291417	1	1	0
DHX57	90957	broad.mit.edu	37	2	39089419	39089419	+	Missense_Mutation	SNP	C	C	A	rs145119195		TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr2:39089419C>A	ENST00000295373.6	-	4	566	c.440G>T	c.(439-441)cGg>cTg	p.R147L	AC018693.6_ENST00000442829.1_RNA|DHX57_ENST00000479345.2_5'UTR	NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	147							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TGGCCAGTACCGCTCATCGTT	0.463000													3	30					0.115264	0.115264	1	1	0
FRG1B	0	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N|FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													5	93					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29365088	29365088	+	Silent	SNP	T	T	C	rs144790258	by1000genomes	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr6:29365088T>C	ENST00000383555.2	+	1	673	c.612T>C	c.(610-612)atT>atC	p.I204I	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						CGGGGACAATTGCCATGGGCC	0.443000													5	126					0	0	1	0	0
RFPL3	10738	broad.mit.edu	37	22	32754250	32754250	+	Silent	SNP	C	C	T	rs145058885	byFrequency	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr22:32754250C>T	ENST00000249007.4	+	1	397	c.192C>T	c.(190-192)atC>atT	p.I64I	RFPL3_ENST00000397468.1_Silent_p.I35I|RFPL3_ENST00000382088.3_Silent_p.I35I	NM_001098535.1	NP_001092005.1	O75679	RFPL3_HUMAN	ret finger protein-like 3	64							zinc ion binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|stomach(1)	15						TCAAGTGCATCAATTCGCTGC	0.532000													4	84					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39799059	39799060	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr1:39799059_39799060insG	ENST00000564288.1	+	37	7576_7577	c.6799_6800insG	c.(6799-6801)ggafs	p.G2267fs	MACF1_ENST00000539005.1_Intron|MACF1_ENST00000289893.4_Frame_Shift_Ins_p.G707fs|MACF1_ENST00000567887.1_Frame_Shift_Ins_p.G2304fs|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000372915.3_Frame_Shift_Ins_p.G2272fs|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000545844.1_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2272					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGATAGTGGCAGGGAAATTTTT	0.391													12	85	---	---	---	---					
RP11-1252I4.2	0	broad.mit.edu	37	5	177398373	177398396	+	RNA	DEL	AGGACGAAGAGCTGGAGAGCGCCA	AGGACGAAGAGCTGGAGAGCGCCA	-	rs70994948		TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr5:177398373_177398396delAGGACGAAGAGCTGGAGAGCGCCA	ENST00000511650.1	+	0	145																											GTCCCCGGGGAGGACGAAGAGCTGGAGAGCGCCAAGGACGACGA	0.683													3	3	---	---	---	---					
STK19	8859	broad.mit.edu	37	6	31939829	31939830	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr6:31939829_31939830insA	ENST00000375331.2	+	1	222_223	c.56_57insA	c.(55-57)gaafs	p.E19fs	DOM3Z_ENST00000375349.3_5'UTR|DOM3Z_ENST00000478221.1_5'UTR|STK19_ENST00000375333.2_Frame_Shift_Ins_p.E19fs|DOM3Z_ENST00000337523.5_5'UTR	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	19						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						CAGTGGCGGGCAAACCCCTCCC	0.634													34	152	---	---	---	---					
HLA-DRB6	0	broad.mit.edu	37	6	32521769	32521771	+	RNA	DEL	ATT	ATT	-	rs77824792	by1000genomes	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr6:32521769_32521771delATT	ENST00000411500.1	-	0	740					NR_001298.1																						AGGTTTAGTGATTTTTATTCCAA	0.429													5	3	---	---	---	---					
PODXL	5420	broad.mit.edu	37	7	131241030	131241035	+	In_Frame_Del	DEL	GGCGAC	GGCGAC	-	rs11277659		TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr7:131241030_131241035delGGCGAC	ENST00000541194.1	-	1	341_346	c.84_89delGTCGCC	c.(82-90)ccc>cc	p.PSP28del	PODXL_ENST00000322985.9_In_Frame_Del_p.PSP28del|PODXL_ENST00000378555.3_In_Frame_Del_p.PSP28del|PODXL_ENST00000537928.1_In_Frame_Del_p.PSP28del|PODXL_ENST00000465001.1_Intron	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	28					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle		p.P30_S31delPS(2)		NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					ATTCTGGGAGggcgacggcgacggcg	0.748													3	6	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396278	+	RNA	INS	-	-	T	rs148140777	by1000genomes	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr10:118396277_118396278insT	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000298771.7_RNA|PNLIPRP2_ENST00000433618.4_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTTT	0.421													4	3	---	---	---	---					
TSPAN4	0	broad.mit.edu	37	11	864443	864445	+	In_Frame_Del	DEL	CTG	CTG	-	rs61867552	byFrequency	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr11:864443_864445delCTG	ENST00000397404.1	+	5	521_523	c.262_264delCTG	c.(262-264)del	p.L92del	TSPAN4_ENST00000397396.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000409543.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000409531.1_In_Frame_Del_p.L111del|TSPAN4_ENST00000525201.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000397397.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000397406.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000346501.4_In_Frame_Del_p.L92del|TSPAN4_ENST00000397408.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000397411.2_In_Frame_Del_p.L92del	NM_001025237.1	NP_001020408.1	O14817	TSN4_HUMAN	tetraspanin 4	92					protein complex assembly	integral to plasma membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	3		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGTTCTTCCTGCTGCTGCTGC	0.650													8	160	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132547093	132547094	+	In_Frame_Ins	INS	-	-	CAG	rs113304321	by1000genomes	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr12:132547093_132547094insCAG	ENST00000333577.4	+	48	8398_8399	c.8289_8290insCAG	c.(8287-8292)caagca>caCAGagca	p.2763_2763Q>HR	EP400_ENST00000389562.2_In_Frame_Ins_p.2726_2726Q>HR|EP400_ENST00000332482.4_In_Frame_Ins_p.2690_2690Q>HR|EP400_ENST00000330386.6_In_Frame_Ins_p.2646_2646Q>HR|EP400_ENST00000389561.2_In_Frame_Ins_p.2727_2727Q>HR			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagca	0.564													22	50	---	---	---	---					
VEZF1	7716	broad.mit.edu	37	17	56056587	56056589	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr17:56056587_56056589delTGT	ENST00000584396.1	-	5	1123_1125	c.1035_1037delACA	c.(1033-1038)cat>ca	p.QH345del	VEZF1_ENST00000581208.1_In_Frame_Del_p.QH354del			Q14119	VEZF1_HUMAN	vascular endothelial zinc finger 1	354	Poly-Gln.				cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|lung(5)|ovary(1)	10						GCTTGTCACAtgttgttgttgtt	0.473													7	195	---	---	---	---					
LYPD3	27076	broad.mit.edu	37	19	43969653	43969655	+	In_Frame_Del	DEL	AGC	AGC	-	rs141441894	byFrequency	TCGA-ET-A4KQ-01A-12D-A257-08	TCGA-ET-A4KQ-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b7c14ddc-0f13-4c93-8996-a9e9a6d0ab1e	096007b2-e058-4848-8a88-4fb06e30b2d5	g.chr19:43969653_43969655delAGC	ENST00000244333.3	-	1	157_159	c.69_71delGCT	c.(67-72)ctt>ct	p.LL23del		NM_014400.2	NP_055215.2	O95274	LYPD3_HUMAN	LY6/PLAUR domain containing 3	23						anchored to plasma membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|upper_aerodigestive_tract(2)	11		Prostate(69;0.0153)				ACCTCCGCGAAGCAGCAGCAGCA	0.675													7	201	---	---	---	---					
