Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF354A	6940	broad.mit.edu	37	5	178152399	178152399	+	Silent	SNP	G	G	A	rs142721313	byFrequency	TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr5:178152399G>A	ENST00000335815.2	-	4	431	c.234C>T	c.(232-234)gaC>gaT	p.D78D		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	78	KRAB.				regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		CGCCAGAACCGTCTTTCTCCA	0.527000													6	147					0	0	0.047766	0	0
CCDC108	255101	broad.mit.edu	37	2	219886587	219886587	+	Silent	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr2:219886587G>A	ENST00000341552.5	-	18	3128	c.3045C>T	c.(3043-3045)gtC>gtT	p.V1015V	CCDC108_ENST00000453220.1_Silent_p.V1015V|CCDC108_ENST00000441968.1_Silent_p.V1015V	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1015						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CATTCAGGAGGACAAGGAACC	0.607000													66	137					0	0	0.139131	0	0
PRKD1	5587	broad.mit.edu	37	14	30105538	30105538	+	Missense_Mutation	SNP	T	T	C			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr14:30105538T>C	ENST00000331968.5	-	7	1377	c.1148A>G	c.(1147-1149)cAa>cGa	p.Q383R	PRKD1_ENST00000415220.2_Missense_Mutation_p.Q391R	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	383					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GTCTGGATCTTGCATCTCGCC	0.537000													102	120					0	0	0.139131	0	0
THAP5	168451	broad.mit.edu	37	7	108204990	108204990	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr7:108204990G>A	ENST00000415914.3	-	3	986	c.833C>T	c.(832-834)gCt>gTt	p.A278V	THAP5_ENST00000313516.5_Missense_Mutation_p.A236V|THAP5_ENST00000493722.1_5'UTR	NM_001130475.1	NP_001123947.1	Q7Z6K1	THAP5_HUMAN	THAP domain containing 5	278					cell cycle|negative regulation of cell cycle	nucleus	DNA binding|metal ion binding|protease binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8						AGAATTTTCAGCAGGTACAAA	0.328000													3	33					0	0	0.115264	0	0
AP005901.1	0	broad.mit.edu	37	18	15323276	15323276	+	RNA	SNP	A	A	T			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr18:15323276A>T	ENST00000455308.2	-	0	572					NR_027417.1																						ATCAACTGCAATTGCATTTGC	0.308000													3	18					0	0	0.009096	0	0
ALCAM	214	broad.mit.edu	37	3	105252457	105252457	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr3:105252457G>A	ENST00000306107.5	+	5	970	c.470G>A	c.(469-471)tGc>tAc	p.C157Y	ALCAM_ENST00000481337.1_3'UTR|ALCAM_ENST00000486979.2_Missense_Mutation_p.C106Y|ALCAM_ENST00000472644.2_Missense_Mutation_p.C157Y|ALCAM_ENST00000389927.4_5'UTR	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	157	Ig-like V-type 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						TTGGGTGACTGCATTTCAGAA	0.443000													45	49					0	0	0.139131	0	0
PLP1	5354	broad.mit.edu	37	X	103041545	103041545	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chrX:103041545G>A	ENST00000418604.1	+	4	623	c.343G>A	c.(343-345)Gca>Aca	p.A115T	PLP1_ENST00000361621.2_Missense_Mutation_p.A115T|PLP1_ENST00000303958.2_Missense_Mutation_p.A115T	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	115					cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						GGGCCTGAGCGCAACGGTAAC	0.582000													4	171					0	0	0.009096	0	0
CKAP2L	150468	broad.mit.edu	37	2	113513632	113513632	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr2:113513632G>A	ENST00000541405.1	-	4	1344	c.821C>T	c.(820-822)aCt>aTt	p.T274I	CKAP2L_ENST00000302450.6_Missense_Mutation_p.T439I			Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	439						centrosome				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	28						ATCAGCTTGAGTTTTGGGAGC	0.408000													62	70					0	0	0.139131	0	0
IGFBP5	3488	broad.mit.edu	37	2	217541606	217541606	+	Splice_Site	SNP	C	C	G			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr2:217541606C>G	ENST00000233813.4	-	4	1437		c.e4-1			NM_000599.3	NP_000590.1	P24593	IBP5_HUMAN	insulin-like growth factor binding protein 5						negative regulation of insulin-like growth factor receptor signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of translation|signal transduction		insulin-like growth factor I binding			endometrium(1)|large_intestine(3)|lung(1)	5		Renal(323;0.0822)		Epithelial(149;2.1e-06)|all cancers(144;0.000165)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGGTTTGCACTGGGGTGAGT	0.617000													5	334					0	0	0.029380	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													4	100					0	0	0.009096	0	0
AHNAK2	113146	broad.mit.edu	37	14	105418145	105418145	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr14:105418145G>A	ENST00000333244.5	-	7	3762	c.3643C>T	c.(3643-3645)Ccc>Tcc	p.P1215S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1215						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCGGAAGGGGGCTGAATGCTG	0.647000													2	0					0	0	0.021553	0	0
SRSF5	6430	broad.mit.edu	37	14	70237718	70237718	+	Silent	SNP	T	T	G			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr14:70237718T>G	ENST00000553521.1	+	8	1900	c.447T>G	c.(445-447)gtT>gtG	p.V149V	SRSF5_ENST00000557154.1_Silent_p.V149V|SRSF5_ENST00000553635.1_Silent_p.V146V|SRSF5_ENST00000556587.1_3'UTR|SRSF5_ENST00000394366.2_Silent_p.V149V			Q13243	SRSF5_HUMAN	serine/arginine-rich splicing factor 5	149	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding			large_intestine(1)|liver(1)	2						TTAGGGTGGTTGAGTTTGCCT	0.358000													6	24					0	0	0.058154	0	0
LTF	4057	broad.mit.edu	37	3	46484938	46484938	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr3:46484938G>A	ENST00000231751.4	-	13	1944	c.1649C>T	c.(1648-1650)gCt>gTt	p.A550V	LTF_ENST00000426532.2_Missense_Mutation_p.A506V|LTF_ENST00000417439.1_Missense_Mutation_p.A548V	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	550	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	TCACCGGAAAGCCCCAGTGTA	0.532000													80	108					0	0	0.139131	0	0
RP11-445N18.7	0	broad.mit.edu	37	10	45652269	45652269	+	RNA	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr10:45652269G>A	ENST00000427229.2	+	0	1783																											CACCCTTGGCGGAAAGAACAC	0.473000													3	41					0	0	0.021553	0	0
ATP2B4	493	broad.mit.edu	37	1	203680123	203680123	+	Missense_Mutation	SNP	A	A	G			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr1:203680123A>G	ENST00000357681.5	+	12	3041	c.1918A>G	c.(1918-1920)Ata>Gta	p.I640V	ATP2B4_ENST00000391954.2_Missense_Mutation_p.I640V|ATP2B4_ENST00000341360.2_Missense_Mutation_p.I640V|ATP2B4_ENST00000367219.3_Missense_Mutation_p.I628V|ATP2B4_ENST00000367218.3_Missense_Mutation_p.I640V	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	640					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GACTATCTGCATAGCTTACCG	0.532000													42	82					0	0	0.139131	0	0
LDHA	3939	broad.mit.edu	37	11	18427040	18427040	+	Missense_Mutation	SNP	T	T	C			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr11:18427040T>C	ENST00000422447.3	+	7	1028	c.755T>C	c.(754-756)aTt>aCt	p.I252T	LDHA_ENST00000542179.1_Missense_Mutation_p.I252T|LDHA_ENST00000540430.1_Missense_Mutation_p.I281T|LDHA_ENST00000430553.2_Missense_Mutation_p.I194T|LDHA_ENST00000396222.2_Intron|LDHA_ENST00000379412.5_Missense_Mutation_p.I252T|LDHA_ENST00000227157.4_Intron	NM_001135239.1|NM_005566.3	NP_001128711.1|NP_005557.1	P00338	LDHA_HUMAN	lactate dehydrogenase A	252					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(4)	12					NADH(DB00157)	TCCTGGGCTATTGGACTCTCT	0.443000													4	72					0	0	0.014758	0	0
PRG4	10216	broad.mit.edu	37	1	186276981	186276981	+	Silent	SNP	A	A	G			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr1:186276981A>G	ENST00000445192.2	+	7	2175	c.2130A>G	c.(2128-2130)aaA>aaG	p.K710K	PRG4_ENST00000367483.4_Silent_p.K669K|PRG4_ENST00000367485.4_Silent_p.K617K|PRG4_ENST00000367486.3_Silent_p.K667K|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	710	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTACCCCTAAAGGGACTGCTC	0.582000													3	122					0	0	0.009096	0	0
TRIO	7204	broad.mit.edu	37	5	14297305	14297305	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr5:14297305C>T	ENST00000344204.4	+	7	1325	c.1301C>T	c.(1300-1302)gCg>gTg	p.A434V	TRIO_ENST00000537187.1_Missense_Mutation_p.A434V|TRIO_ENST00000509967.2_Missense_Mutation_p.A385V	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	434					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					AAGGCGTTTGCGGCAGCCCTG	0.602000													3	46					0	0	0.115264	0	0
ANGPTL6	83854	broad.mit.edu	37	19	10204121	10204121	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr19:10204121G>A	ENST00000253109.4	-	5	1364	c.1126C>T	c.(1126-1128)Cgg>Tgg	p.R376W	ANGPTL6_ENST00000592641.1_Missense_Mutation_p.R376W|ANGPTL6_ENST00000589181.1_Missense_Mutation_p.R336W	NM_031917.2	NP_114123.2	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6	376	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)	12			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			TGGCCAAGCCGCAGGCGGTAG	0.597000													3	44					0	0	0.009096	0	0
CCDC15	80071	broad.mit.edu	37	11	124857495	124857495	+	Missense_Mutation	SNP	A	A	C	rs113451248		TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr11:124857495A>C	ENST00000529051.1	+	8	1632	c.1373A>C	c.(1372-1374)cAc>cCc	p.H458P	CCDC15_ENST00000344762.5_Missense_Mutation_p.H458P			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	458						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CATGTTCTCCACAAAGACCAA	0.418000													3	53					0	0	0.115264	0	0
DNM1P47	0	broad.mit.edu	37	15	102304695	102304695	+	RNA	SNP	G	G	C			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr15:102304695G>C	ENST00000561463.1	+	0	12741																											CTGCTTCTCAGAGCTGCTGTC	0.627000													3	10					0	0	0.014758	0	0
ARIH1	25820	broad.mit.edu	37	15	72767235	72767235	+	Silent	SNP	C	C	T			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr15:72767235C>T	ENST00000379887.4	+	1	569	c.255C>T	c.(253-255)ggC>ggT	p.G85G	RP11-1007O24.3_ENST00000565181.1_lincRNA	NM_005744.3	NP_005735.2	Q9Y4X5	ARI1_HUMAN	ariadne RBR E3 ubiquitin protein ligase 1	85	Gly-rich.				ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	14						gcggcggcggcggtggtggtg	0.736000													3	18					0	0	0.009096	0	0
PTPRS	5802	broad.mit.edu	37	19	5206842	5206842	+	Missense_Mutation	SNP	C	C	G			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr19:5206842C>G	ENST00000372412.4	-	38	6026	c.5793G>C	c.(5791-5793)caG>caC	p.Q1931H	PTPRS_ENST00000587303.1_Missense_Mutation_p.Q1930H|PTPRS_ENST00000357368.4_Missense_Mutation_p.Q1930H|PTPRS_ENST00000353284.2_Missense_Mutation_p.Q1483H|PTPRS_ENST00000348075.2_Missense_Mutation_p.Q1892H|PTPRS_ENST00000592099.1_Missense_Mutation_p.Q1483H|PTPRS_ENST00000262963.6_Missense_Mutation_p.Q1910H|PTPRS_ENST00000588552.1_Intron|PTPRS_ENST00000588012.1_Missense_Mutation_p.Q1892H			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1930	Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGTAACAGAACTGGTACTCAT	0.612000													7	99					0	0	0.058154	0	0
ZNF713	349075	broad.mit.edu	37	7	56006963	56006963	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr7:56006963G>A	ENST00000429591.2	+	4	595	c.557G>A	c.(556-558)aGa>aAa	p.R186K	MRPS17_ENST00000426595.1_Intron	NM_182633.1	NP_872439.1	Q8N859	ZN713_HUMAN	zinc finger protein 713	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ATGCAGCAGAGAATTCCTTCC	0.368000													13	28					0	0	0.132662	0	0
CATSPERB	79820	broad.mit.edu	37	14	92088170	92088170	+	Missense_Mutation	SNP	G	G	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr14:92088170G>A	ENST00000256343.3	-	19	2198	c.2042C>T	c.(2041-2043)gCt>gTt	p.A681V		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	681					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				AGGCATGGTAGCAATGGCTAA	0.393000													3	47					0	0	0.115264	0	0
MYH2	4620	broad.mit.edu	37	17	10432293	10432293	+	Missense_Mutation	SNP	C	C	A			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr17:10432293C>A	ENST00000245503.5	-	27	3842	c.3458G>T	c.(3457-3459)aGc>aTc	p.S1153I	MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.S1153I|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1153					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CAGCCTCTCGCTGATCTCCTC	0.617000													90	96					1.33835e-49	1.71476e-49	0.139131	1	0
TSFM	10102	broad.mit.edu	37	12	58176601	58176601	+	Missense_Mutation	SNP	C	C	T			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr12:58176601C>T	ENST00000454289.3	+	1	230	c.17C>T	c.(16-18)tCg>tTg	p.S6L	TSFM_ENST00000323833.8_Missense_Mutation_p.S6L|TSFM_ENST00000550559.1_Missense_Mutation_p.S6L|TSFM_ENST00000548851.1_Missense_Mutation_p.S6L|TSFM_ENST00000350762.5_5'UTR|TSFM_ENST00000543727.1_Missense_Mutation_p.S6L|RP11-571M6.15_ENST00000471530.1_Intron|TSFM_ENST00000540550.1_Missense_Mutation_p.S6L|RP11-571M6.15_ENST00000553083.1_Intron	NM_005726.5	NP_005717.3	P43897	EFTS_HUMAN	Ts translation elongation factor, mitochondrial	6					regulation of transcription elongation, DNA-dependent	mitochondrion|nucleus	translation elongation factor activity			endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)	8	all_cancers(7;6.31e-80)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CTGCTGCGGTCGCTGCGCGTG	0.652000											OREG0021954	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	9					0	0	0.021553	0	0
LCE1E	353135	broad.mit.edu	37	1	152760020	152760020	+	Missense_Mutation	SNP	A	A	G			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr1:152760020A>G	ENST00000368770.3	+	2	298	c.245A>G	c.(244-246)cAc>cGc	p.H82R	LCE1E_ENST00000368771.1_Missense_Mutation_p.H82R	NM_178353.1	NP_848130.1	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	82	Cys-rich.				keratinization					lung(5)|stomach(1)	6	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACCACAGGCACCACAGGTCC	0.697000													5	119					0	0	0.014758	0	0
DLEC1	9940	broad.mit.edu	37	3	38162039	38162040	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr3:38162039_38162040delGA	ENST00000308059.6	+	34	4826_4827	c.4805_4806delGA	c.(4804-4806)gfs	p.G1602fs	DLEC1_ENST00000346219.3_Frame_Shift_Del_p.G1602fs|DLEC1_ENST00000452631.2_Frame_Shift_Del_p.G1605fs			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	1602					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		AGTGCGAGTGGAGAGAGAGAGA	0.579													7	121	---	---	---	---					
LNP1	348801	broad.mit.edu	37	3	100148586	100148588	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr3:100148586_100148588delGAT	ENST00000383693.3	+	2	1293_1295	c.13_15delGAT	c.(13-15)del	p.D10del	LNP1_ENST00000489752.1_In_Frame_Del_p.D10del	NM_001085451.1	NP_001078920.1	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	10	Poly-Asp.									cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6						GGAGCACAAAGATGATGATGATG	0.507													7	334	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134073569	134073571	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr4:134073569_134073571delCTG	ENST00000264360.4	+	1	3100_3102	c.2274_2276delCTG	c.(2272-2277)ctc>ct	p.LC758del		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	758	Cys-rich.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTGCTGCCTCTGCTGCTGCTGC	0.581													10	69	---	---	---	---					
GNL1	2794	broad.mit.edu	37	6	30513930	30513931	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr6:30513930_30513931delAT	ENST00000376621.3	-	12	2712_2713	c.1742_1743delAT	c.(1741-1743)gfs	p.D581fs		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	581	Asp/Glu-rich (highly acidic).				response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						GGGTctcctcatccccttctcc	0.639													2	4	---	---	---	---					
AGAP11	119385	broad.mit.edu	37	10	88753100	88753100	+	RNA	DEL	T	T	-			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr10:88753100delT	ENST00000444431.1	+	0	64				RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										ATGAGTTTACTTTTTTTTTTA	0.303													4	6	---	---	---	---					
KANK3	256949	broad.mit.edu	37	19	8398950	8398961	+	In_Frame_Del	DEL	TCGCTGTCGCCA	TCGCTGTCGCCA	-	rs111751275		TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr19:8398950_8398961delTCGCTGTCGCCA	ENST00000330915.3	-	5	1532_1543	c.1467_1478delTGGCGACAGCGA	c.(1465-1479)gag>ga	p.DGDSE489del	KANK3_ENST00000593649.1_In_Frame_Del_p.DGDSE489del	NM_198471.2	NP_940873.2	Q6NY19	KANK3_HUMAN	KN motif and ankyrin repeat domains 3	489								p.D489_S492delDGDS(2)		breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						GCCACCGTTCTCGCTGTCGCCATCGCTGTCGC	0.717													3	6	---	---	---	---					
PMEPA1	56937	broad.mit.edu	37	20	56284593	56284595	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-J8-A3O1-01A-11D-A21A-08	TCGA-J8-A3O1-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1471f233-85c1-4689-853a-01947d5ba299	d48f2242-1f17-4fef-a647-c19839582493	g.chr20:56284593_56284595delCGG	ENST00000341744.3	-	1	363_365	c.44_46delCCG	c.(43-48)ggg>g	p.AG15del	PMEPA1_ENST00000347215.4_Intron|PMEPA1_ENST00000265626.4_Intron|PMEPA1_ENST00000472841.1_Intron|PMEPA1_ENST00000395816.3_Intron	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	15					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						TTGGGCTgcccggcggcggcggc	0.734													4	9	---	---	---	---					
