Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PSG7	5676	broad.mit.edu	37	19	43439887	43439887	+	RNA	SNP	T	T	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr19:43439887T>A	ENST00000406070.2	-	0	195				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TGACTTGGGCTGTGGTGGGCG	0.493000													7	258					0	0	1	0	0
REG3A	5068	broad.mit.edu	37	2	79385821	79385821	+	Missense_Mutation	SNP	A	A	T			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr2:79385821A>T	ENST00000393878.1	-	2	405	c.151T>A	c.(151-153)Tgc>Agc	p.C51S	REG3A_ENST00000409839.3_Missense_Mutation_p.C51S|REG3A_ENST00000305165.2_Missense_Mutation_p.C51S|AC011754.1_ENST00000415201.1_RNA	NM_138938.2	NP_620355.1	Q06141	REG3A_HUMAN	regenerating islet-derived 3 alpha	51	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			breast(2)|large_intestine(4)|lung(41)|prostate(2)|skin(1)	50						AAGGCATAGCAGTGGGAGCCA	0.577000													28	39					0	0	1	0	0
AP4M1	9179	broad.mit.edu	37	7	99703909	99703909	+	Silent	SNP	G	G	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr7:99703909G>A	ENST00000429084.1	+	13	1199	c.1041G>A	c.(1039-1041)gtG>gtA	p.V347V	AP4M1_ENST00000421755.1_Silent_p.V340V|AP4M1_ENST00000422582.1_Silent_p.V212V|AP4M1_ENST00000359593.4_Silent_p.V340V			O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	340	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTCGAGGGGTGGTCAGGTGAG	0.617000													12	21					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143425445	143425445	+	Silent	SNP	G	G	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr8:143425445G>A	ENST00000524325.1	-	4	802	c.627C>T	c.(625-627)ccC>ccT	p.P209P	TSNARE1_ENST00000307180.3_Silent_p.P209P|TSNARE1_ENST00000519651.1_Intron|TSNARE1_ENST00000520166.1_Silent_p.P209P			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	209					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					AACCAGGGCTGGGGCCATGGG	0.697000													4	46					0	0	1	0	0
LRRC14	9684	broad.mit.edu	37	8	145745726	145745726	+	Missense_Mutation	SNP	G	G	T			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr8:145745726G>T	ENST00000292524.1	+	3	580	c.434G>T	c.(433-435)cGc>cTc	p.R145L	LRRC14_ENST00000529022.1_Missense_Mutation_p.R145L	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	145										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GCCGTAGCTCGCACATGCATT	0.657000													15	93					2.48551e-13	2.65692e-13	1	1	0
TMEM91	641649	broad.mit.edu	37	19	41889651	41889651	+	Missense_Mutation	SNP	A	A	G			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr19:41889651A>G	ENST00000392002.2	+	4	1052	c.392A>G	c.(391-393)cAg>cGg	p.Q131R	TMEM91_ENST00000539627.1_3'UTR|CTC-435M10.3_ENST00000540732.1_Intron|TMEM91_ENST00000436170.2_Intron|TMEM91_ENST00000413014.2_Intron|TMEM91_ENST00000356385.4_3'UTR|BCKDHA_ENST00000595085.1_Intron|TMEM91_ENST00000447302.2_Intron|TMEM91_ENST00000544232.1_Intron|TMEM91_ENST00000542945.1_3'UTR|TMEM91_ENST00000604123.1_Intron	NM_001098821.1	NP_001092291.1			transmembrane protein 91											lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	5						GGGGACATCCAGGGGGCAGGG	0.706000													6	59					0	0	1	0	0
AFMID	125061	broad.mit.edu	37	17	76198628	76198628	+	Missense_Mutation	SNP	A	A	G			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr17:76198628A>G	ENST00000409257.5	+	3	257	c.203A>G	c.(202-204)tAt>tGt	p.Y68C	AFMID_ENST00000327898.5_Missense_Mutation_p.Y68C|AFMID_ENST00000591952.1_Intron|AFMID_ENST00000588800.1_Intron	NM_001010982.4|NM_001145526.2	NP_001010982.2|NP_001138998.1	Q63HM1	AFMID_HUMAN	arylformamidase	68						cytosol|nucleus	arylformamidase activity			autonomic_ganglia(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)	19			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			CATGTCCCCTATGGAGACGGC	0.602000													8	79					0	0	1	0	0
FGL1	2267	broad.mit.edu	37	8	17743027	17743027	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr8:17743027C>T	ENST00000398056.2	-	4	852	c.37G>A	c.(37-39)Gct>Act	p.A13T	FGL1_ENST00000522444.1_Missense_Mutation_p.A13T|FGL1_ENST00000518650.1_Missense_Mutation_p.A13T|FGL1_ENST00000427924.1_Missense_Mutation_p.A13T|FGL1_ENST00000381840.2_Missense_Mutation_p.A13T|FGL1_ENST00000381841.2_Missense_Mutation_p.A13T|FGL1_ENST00000398054.1_Missense_Mutation_p.A13T			Q08830	FGL1_HUMAN	fibrinogen-like 1	13					signal transduction	fibrinogen complex	receptor binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)	13				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		ATTGTCAGAGCGGTGGTAACA	0.343000													4	62					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													6	92					0	0	1	0	0
UPK1B	7348	broad.mit.edu	37	3	118906737	118906737	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr3:118906737G>A	ENST00000264234.3	+	3	334	c.185G>A	c.(184-186)gGc>gAc	p.G62D	UPK1B_ENST00000497685.1_5'UTR|UPK1B_ENST00000460625.1_Missense_Mutation_p.G62D	NM_006952.3	NP_008883.2	O75841	UPK1B_HUMAN	uroplakin 1B	62					epithelial cell differentiation	integral to membrane	structural molecule activity			breast(1)|endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	14				GBM - Glioblastoma multiforme(114;0.222)		GCCTGGATCGGCATATTTGTG	0.502000													4	128					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33481307	33481307	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr10:33481307C>T	ENST00000265371.4	-	14	2489	c.1964G>A	c.(1963-1965)gGc>gAc	p.G655D	NRP1_ENST00000374867.2_Missense_Mutation_p.G655D|NRP1_ENST00000395995.1_Missense_Mutation_p.G655D			O14786	NRP1_HUMAN	neuropilin 1	655	MAM.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	CTTGTGAGAGCCCCAGCCAAA	0.453000													9	339					0	0	1	0	0
WDR18	57418	broad.mit.edu	37	19	990319	990319	+	Silent	SNP	C	C	T			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr19:990319C>T	ENST00000251289.5	+	4	575	c.552C>T	c.(550-552)ggC>ggT	p.G184G	WDR18_ENST00000587001.2_Silent_p.G184G	NM_024100.3	NP_077005.2	Q9BV38	WDR18_HUMAN	WD repeat domain 18	184										endometrium(1)|kidney(2)|lung(2)|skin(2)	7		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTTGGGGGCCCCCTGGCCC	0.716000													3	14					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248344028	248344028	+	Silent	SNP	G	G	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr1:248344028G>A	ENST00000359682.2	+	1	741	c.741G>A	c.(739-741)gtG>gtA	p.V247V		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACCTCATGGTGGTGGGAATGT	0.493000													5	240					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81381500	81381500	+	Silent	SNP	G	G	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr7:81381500G>A	ENST00000222390.5	-	5	787	c.561C>T	c.(559-561)ccC>ccT	p.P187P	HGF_ENST00000423064.2_Silent_p.P187P|HGF_ENST00000444829.2_Silent_p.P187P|HGF_ENST00000457544.2_Silent_p.P182P|HGF_ENST00000453411.1_Silent_p.P182P	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	187	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TGAAACACCAGGGTCCCCCTT	0.443000													4	64					0	0	1	0	0
SLC25A43	203427	broad.mit.edu	37	X	118540494	118540494	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chrX:118540494C>T	ENST00000217909.7	+	2	691	c.347C>T	c.(346-348)gCa>gTa	p.A116V	SLC25A43_ENST00000488158.1_3'UTR|SLC25A43_ENST00000336249.7_Missense_Mutation_p.A116V	NM_145305.2	NP_660348.2	Q8WUT9	S2543_HUMAN	solute carrier family 25, member 43	116					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	9						GGGAGTCTCGCAGGCATGGTT	0.512000													4	94					0	0	1	0	0
FRG1	2483	broad.mit.edu	37	4	190878646	190878646	+	Nonsense_Mutation	SNP	G	G	T			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr4:190878646G>T	ENST00000226798.4	+	6	748	c.526G>T	c.(526-528)Gaa>Taa	p.E176*	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	176					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus		p.E176*(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		AGGAGAAGAAGAAATGATCAA	0.373000													4	75					1.12685e-05	1.12685e-05	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152651592	152651592	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr6:152651592G>A	ENST00000367255.5	-	78	14829	c.14228C>T	c.(14227-14229)aCa>aTa	p.T4743I	SYNE1_ENST00000423061.1_Missense_Mutation_p.T4672I|SYNE1_ENST00000265368.4_Missense_Mutation_p.T4743I|SYNE1_ENST00000341594.5_Missense_Mutation_p.T4490I|SYNE1_ENST00000448038.1_Missense_Mutation_p.T4672I	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4743					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGGCTGACCTGTGCTGCGAAA	0.517000										HNSCC(10;0.0054)			6	73					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32198783	32198783	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr22:32198783G>A	ENST00000400246.1	+	15	1182	c.1040G>A	c.(1039-1041)cGc>cAc	p.R347H	DEPDC5_ENST00000382105.2_Missense_Mutation_p.R347H|DEPDC5_ENST00000382111.2_Missense_Mutation_p.R347H|DEPDC5_ENST00000382112.3_Missense_Mutation_p.R347H|DEPDC5_ENST00000266091.3_Missense_Mutation_p.R347H|DEPDC5_ENST00000536766.1_Missense_Mutation_p.R319H|DEPDC5_ENST00000400242.3_Missense_Mutation_p.R347H|DEPDC5_ENST00000535622.1_Missense_Mutation_p.R347H|DEPDC5_ENST00000400248.1_Missense_Mutation_p.R347H|DEPDC5_ENST00000400249.2_Missense_Mutation_p.R347H			O75140	DEPD5_HUMAN	DEP domain containing 5	347					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						GAAGTGGACCGCCTACTCATG	0.498000													4	110					0	0	1	0	0
BCL9	607	broad.mit.edu	37	1	147091046	147091046	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr1:147091046C>T	ENST00000234739.3	+	8	1825	c.1085C>T	c.(1084-1086)tCc>tTc	p.S362F		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	362	CTNNB1-binding.|Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					CGGGAGCGCTCCTTACAAACT	0.567000			T	"""IGH@, IGL@"""	B-ALL								7	163					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43439893	43439893	+	RNA	SNP	G	G	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr19:43439893G>A	ENST00000406070.2	-	0	189				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GGGCTGTGGTGGGCGGGTTCC	0.507000													8	253					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8215408	8215408	+	Silent	SNP	T	T	C			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr17:8215408T>C	ENST00000361926.3	+	2	161	c.51T>C	c.(49-51)ccT>ccC	p.P17P	ARHGEF15_ENST00000421050.1_Silent_p.P17P	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	17	Pro-rich.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						AGAAGCCCCCTCGGATCATCC	0.627000													5	60					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				29	45					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999469	46999469	+	Missense_Mutation	SNP	C	C	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr10:46999469C>A	ENST00000374314.4	+	1	1544	c.589C>A	c.(589-591)Cca>Aca	p.P197T	GPRIN2_ENST00000374317.1_Missense_Mutation_p.P197T			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	197										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						GTTGTCAGTGCCACCACTAGA	0.632000													9	26					1.12685e-05	1.12685e-05	1	1	0
ZNF623	9831	broad.mit.edu	37	8	144732640	144732640	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr8:144732640G>A	ENST00000501748.2	+	1	687	c.598G>A	c.(598-600)Gtt>Att	p.V200I	ZNF623_ENST00000458270.2_Missense_Mutation_p.V160I|ZNF623_ENST00000526926.1_Missense_Mutation_p.V160I	NM_014789.3	NP_055604.3	O75123	ZN623_HUMAN	zinc finger protein 623	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(6)|lung(11)|prostate(1)|stomach(1)|urinary_tract(3)	27	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCATCAGCGCGTTCATTCAGG	0.473000													4	108					0	0	1	0	0
GBAP1	0	broad.mit.edu	37	1	155186353	155186353	+	RNA	SNP	T	T	C			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr1:155186353T>C	ENST00000486869.1	-	0	715					NR_002188.2																						AGCAGAAGGCTCATTTTCAGC	0.527000													3	27					0	0	1	0	0
XKR5	389610	broad.mit.edu	37	8	6679301	6679302	+	RNA	DEL	CA	CA	-			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr8:6679301_6679302delCA	ENST00000518724.1	-	0	958							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		TGCATTGGTGcacacacacaca	0.401													2	4	---	---	---	---					
CCDC86	79080	broad.mit.edu	37	11	60610042	60610043	+	Frame_Shift_Ins	INS	-	-	C	rs138154956		TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr11:60610042_60610043insC	ENST00000227520.5	+	1	499_500	c.445_446insC	c.(445-447)cccfs	p.P149fs	RP11-804A23.4_ENST00000538705.1_RNA|RP11-804A23.2_ENST00000539897.1_RNA	NM_024098.3	NP_077003.1	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	149	Pro-rich.				interspecies interaction between organisms	nucleus				endometrium(1)|large_intestine(2)|liver(2)|lung(2)|urinary_tract(3)	10						GACCCCGGGGGCCCCCCAGCAT	0.634													7	97	---	---	---	---					
KRT1	3848	broad.mit.edu	37	12	53069236	53069256	+	In_Frame_Del	DEL	TAGCTGCTACCTCCGGAGCCA	TAGCTGCTACCTCCGGAGCCA	-	rs66529359	by1000genomes	TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr12:53069236_53069256delTAGCTGCTACCTCCGGAGCCA	ENST00000252244.3	-	9	1714_1734	c.1656_1676delTGGCTCCGGAGGTAGCAGCTA	c.(1654-1677)tac>ta	p.YGSGGSSY552del		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	552	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding	p.S557_G563delSSYGSGG(3)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						tccggagccgtagctgctacctccggagccatagctgccac	0.688													9	9	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132547093	132547094	+	In_Frame_Ins	INS	-	-	CAG	rs113304321	by1000genomes	TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr12:132547093_132547094insCAG	ENST00000333577.4	+	48	8398_8399	c.8289_8290insCAG	c.(8287-8292)caagca>caCAGagca	p.2763_2763Q>HR	EP400_ENST00000330386.6_In_Frame_Ins_p.2646_2646Q>HR|EP400_ENST00000332482.4_In_Frame_Ins_p.2690_2690Q>HR|EP400_ENST00000389562.2_In_Frame_Ins_p.2726_2726Q>HR|EP400_ENST00000389561.2_In_Frame_Ins_p.2727_2727Q>HR			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagca	0.564													14	66	---	---	---	---					
TSC22D1	8848	broad.mit.edu	37	13	45148706	45148708	+	In_Frame_Del	DEL	TGC	TGC	-	rs112613609		TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr13:45148706_45148708delTGC	ENST00000458659.2	-	1	1993_1995	c.1503_1505delGCA	c.(1501-1506)caa>ca	p.QQ507del	TSC22D1_ENST00000501704.2_In_Frame_Del_p.QQ507del	NM_183422.3	NP_904358.2	Q15714	T22D1_HUMAN	TSC22 domain family, member 1	507	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		ttgttgttgttgctgctgctgct	0.507													7	154	---	---	---	---					
FARP1	10160	broad.mit.edu	37	13	99038023	99038023	+	Frame_Shift_Del	DEL	G	G	-			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr13:99038023delG	ENST00000376586.2	+	8	1050	c.714delG	c.(712-714)acfs	p.T238fs	FARP1_ENST00000595437.1_Frame_Shift_Del_p.T238fs|FARP1_ENST00000319562.6_Frame_Shift_Del_p.T238fs			Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	238	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			GGGAAGGCACGAAGATCAATC	0.537													7	79	---	---	---	---					
PML	5371	broad.mit.edu	37	15	74287226	74287226	+	Frame_Shift_Del	DEL	C	C	-			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr15:74287226delC	ENST00000565898.1	+	1	157	c.73delC	c.(73-75)ccfs	p.P26fs	PML_ENST00000563500.1_Frame_Shift_Del_p.P26fs|PML_ENST00000268058.3_Frame_Shift_Del_p.P26fs|PML_ENST00000268059.6_Frame_Shift_Del_p.P26fs|PML_ENST00000436891.3_Frame_Shift_Del_p.P26fs|PML_ENST00000395132.2_Frame_Shift_Del_p.P26fs|PML_ENST00000395135.3_Frame_Shift_Del_p.P26fs|PML_ENST00000359928.4_Frame_Shift_Del_p.P26fs|PML_ENST00000354026.6_Frame_Shift_Del_p.P26fs|PML_ENST00000569477.1_Frame_Shift_Del_p.P26fs|PML_ENST00000567543.1_Frame_Shift_Del_p.P26fs|PML_ENST00000569965.1_Frame_Shift_Del_p.P26fs|PML_ENST00000435786.2_Frame_Shift_Del_p.P26fs|PML_ENST00000564428.1_Frame_Shift_Del_p.P26fs			P29590	PML_HUMAN	promyelocytic leukemia	26	Pro-rich.				cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						CACCATGCCTCCCCCCGAGAC	0.652			T	"""RARA, PAX5"""	"""APL, ALL"""								2	4	---	---	---	---					
MADCAM1	8174	broad.mit.edu	37	19	501701	501702	+	In_Frame_Ins	INS	-	-	ACACCACCTCCCCGGAGCCTCCCA	rs71171990	byFrequency	TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr19:501701_501702insACACCACCTCCCCGGAGCCTCCCA	ENST00000587541.1	+	2	897_898	c.43_44insACACCACCTCCCCGGAGCCTCCCA	c.(43-45)cac>ACACCACCTCCCCGGAGCCTCCCAcac	p.14_15insTPPPRSLP	MADCAM1_ENST00000215637.3_In_Frame_Ins_p.233_234insTPPPRSLP|MADCAM1_ENST00000346144.4_Intron|MADCAM1_ENST00000382683.4_Intron|AC005775.2_ENST00000592413.1_RNA			Q13477	MADCA_HUMAN	mucosal vascular addressin cell adhesion molecule 1	233					cell adhesion|immune response|regulation of immune response|signal transduction	integral to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|prostate(1)|skin(2)	10		all_cancers(10;4.25e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGCCTCCCGACACCACCTCC	0.653													16	33	---	---	---	---					
AC005307.3	0	broad.mit.edu	37	19	29197819	29197819	+	RNA	DEL	C	C	-			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr19:29197819delC	ENST00000592347.1	-	0	642																											GTTGTGTCTTCCATACCCACC	0.398													2	4	---	---	---	---					
AC008103.5	0	broad.mit.edu	37	22	18843723	18843724	+	RNA	INS	-	-	A			TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr22:18843723_18843724insA	ENST00000412938.1	+	0	2337																											AGGGGCACCCCACGGCCTGGAG	0.619													4	6	---	---	---	---					
GUSBP11	0	broad.mit.edu	37	22	24000276	24000281	+	RNA	DEL	TCCTCT	TCCTCT	-	rs138300012		TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chr22:24000276_24000281delTCCTCT	ENST00000417194.1	-	0	5003_5004																											ttcttttTTctcctcttcctcttcct	0.476													2	4	---	---	---	---					
ZNF41	7592	broad.mit.edu	37	X	47326846	47326846	+	Frame_Shift_Del	DEL	G	G	-	rs34711808		TCGA-KS-A41F-01A-11D-A23M-08	TCGA-KS-A41F-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58701cf8-a5ac-4479-8157-0d1f04688a4b	476ae26c-331a-4fbe-a53f-aae55bfb5de3	g.chrX:47326846delG	ENST00000377065.4	-	2	674	c.35delC	c.(34-36)cgfs	p.P12fs	ZNF41_ENST00000397050.2_Frame_Shift_Del_p.R9fs|ZNF41_ENST00000313116.7_Frame_Shift_Del_p.P12fs|ZNF41_ENST00000465311.1_5'UTR	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	12						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				AGCCAGGGCCGGGGACCATGG	0.612													2	4	---	---	---	---					
