Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RGPD3	653489	broad.mit.edu	37	2	107049631	107049631	+	Silent	SNP	C	C	T			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr2:107049631C>T	ENST00000409886.3	-	16	2403	c.2316G>A	c.(2314-2316)gcG>gcA	p.A772A	RGPD3_ENST00000304514.7_Silent_p.A772A	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	772					intracellular transport		binding	p.A772A(4)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TTTCTGAATCCGCATTTCGCA	0.373000													6	304					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228434397	228434397	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr1:228434397C>T	ENST00000570156.2	+	14	4276	c.4202C>T	c.(4201-4203)gCg>gTg	p.A1401V	OBSCN_ENST00000422127.1_Missense_Mutation_p.A1309V|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000284548.11_Missense_Mutation_p.A1309V	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	383	Ig-like 14.			V -> A (in Ref. 1; CAC85749).|V -> T (in Ref. 1; CAC85746).	apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ATAGAGGCTGCGGGCTGCATG	0.637000													4	158					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													5	84					0	0	1	0	0
CYP11B1	0	broad.mit.edu	37	8	143957743	143957743	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr8:143957743C>T	ENST00000292427.4	-	5	900	c.868G>A	c.(868-870)Gtg>Atg	p.V290M	CYP11B1_ENST00000517471.1_Missense_Mutation_p.V290M|CYP11B1_ENST00000377675.3_Missense_Mutation_p.V361M	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	290					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity	p.V290M(1)		central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	AGCTCCGCCACGATGCTGGTG	0.587000									Familial Hyperaldosteronism type I				13	29					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123193497	123193497	+	Missense_Mutation	SNP	C	C	G			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr4:123193497C>G	ENST00000264501.4	+	48	8756	c.8383C>G	c.(8383-8385)Cta>Gta	p.L2795V	KIAA1109_ENST00000455637.1_Missense_Mutation_p.L2795V|KIAA1109_ENST00000388738.3_Missense_Mutation_p.L2795V			Q2LD37	K1109_HUMAN	KIAA1109	2795					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TATTGGTGGACTAACAATGGA	0.388000													24	36					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112657210	112657210	+	Silent	SNP	A	A	G			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr12:112657210A>G	ENST00000550722.1	-	45	7011	c.6616T>C	c.(6616-6618)Ttg>Ctg	p.L2206L	HECTD4_ENST00000430131.2_Silent_p.L1930L|HECTD4_ENST00000377560.5_Silent_p.L2180L	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TCAGCCTGCAAAGGAGGTGGT	0.592000													18	63					0	0	1	0	0
SEC24A	10802	broad.mit.edu	37	5	133996961	133996961	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr5:133996961C>T	ENST00000398844.2	+	2	538	c.250C>T	c.(250-252)Cag>Tag	p.Q84*	SEC24A_ENST00000322887.4_Nonsense_Mutation_p.Q84*	NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	84					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGGATCTGGGCAGACTCTTAA	0.502000													5	179					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			62	110					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34059927	34059927	+	Missense_Mutation	SNP	C	C	T	rs116166982	byFrequency	TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr20:34059927C>T	ENST00000397527.1	+	11	1721	c.1001C>T	c.(1000-1002)gCg>gTg	p.A334V	CEP250_ENST00000342580.4_Missense_Mutation_p.A334V	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	334					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			AGTAGGAATGCGCAAGAGGAG	0.458000													5	212					0	0	1	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74874341	74874341	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr14:74874341C>T	ENST00000331628.3	-	4	861	c.614G>A	c.(613-615)cGg>cAg	p.R205Q	SYNDIG1L_ENST00000554823.1_Missense_Mutation_p.R205Q	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	205					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						GAAGAGGGCCCGGCGGGAGGT	0.637000													7	145					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13769625	13769625	+	Silent	SNP	G	G	A			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr5:13769625G>A	ENST00000265104.4	-	57	9809	c.9705C>T	c.(9703-9705)aaC>aaT	p.N3235N	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3235	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CGGCTTTATCGTTGGCCACTT	0.423000									Kartagener syndrome				6	128					0	0	1	0	0
TCTN2	79867	broad.mit.edu	37	12	124181040	124181040	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr12:124181040C>T	ENST00000303372.5	+	12	1519	c.1391C>T	c.(1390-1392)tCg>tTg	p.S464L	TCTN2_ENST00000426174.2_Missense_Mutation_p.S463L	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	464					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		CTTTGGCAATCGGGTAATCCG	0.368000													18	59					0	0	1	0	0
ABCD1	215	broad.mit.edu	37	X	152991422	152991422	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chrX:152991422G>A	ENST00000218104.3	+	1	1100	c.701G>A	c.(700-702)cGc>cAc	p.R234H	ABCD1_ENST00000370129.4_Missense_Mutation_p.R49H	NM_000033.3	NP_000024.2	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member 1	234	ABC transmembrane type-1.				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(2)	18	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGGGCGGCCCGCTCCCGTGGA	0.687000													7	104					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													5	211					0	0	1	0	0
ALOX5	240	broad.mit.edu	37	10	45920457	45920457	+	Missense_Mutation	SNP	C	C	G			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr10:45920457C>G	ENST00000374391.2	+	6	764	c.711C>G	c.(709-711)ttC>ttG	p.F237L	ALOX5_ENST00000542434.1_Missense_Mutation_p.F237L	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	237	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	GCTACCAGTTCCTGAATGGCT	0.602000													34	70					0	0	1	0	0
COTL1	23406	broad.mit.edu	37	16	84600451	84600451	+	Nonstop_Mutation	SNP	T	T	G			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr16:84600451T>G	ENST00000262428.4	-	4	591	c.429A>C	c.(427-429)taA>taC	p.*143Y	COTL1_ENST00000564057.1_Nonstop_Mutation_p.*74Y|COTL1_ENST00000567278.1_5'UTR	NM_021149.2	NP_066972.1	Q14019	COTL1_HUMAN	coactosin-like 1 (Dictyostelium)	0						cytoplasm|cytoskeleton	actin binding|enzyme binding			endometrium(1)|large_intestine(1)|liver(1)|lung(2)|skin(1)	6						GGGGCTGGGGTTACTCCGTCT	0.622000													5	35					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146077635	146077635	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr5:146077635C>T	ENST00000394413.3	-	3	811	c.241G>A	c.(241-243)Gat>Aat	p.D81N	PPP2R2B_ENST00000356826.3_Missense_Mutation_p.D81N|PPP2R2B_ENST00000453001.1_Missense_Mutation_p.D81N|PPP2R2B_ENST00000508545.2_Missense_Mutation_p.D70N|PPP2R2B_ENST00000394411.4_Missense_Mutation_p.D81N|PPP2R2B_ENST00000394409.3_Missense_Mutation_p.D139N|PPP2R2B_ENST00000394414.1_Missense_Mutation_p.D147N|PPP2R2B_ENST00000336640.6_Missense_Mutation_p.D84N|PPP2R2B_ENST00000504198.1_Missense_Mutation_p.D87N|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394410.2_Missense_Mutation_p.D70N			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	81					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAGGTAATCGAACTCGGGT	0.383000													43	80					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46629486	46629486	+	Silent	SNP	G	G	A			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr17:46629486G>A	ENST00000470495.1	-	1	1798	c.351C>T	c.(349-351)tgC>tgT	p.C117C	HOXB3_ENST00000498678.1_Silent_p.C117C|HOXB3_ENST00000490677.1_Intron|HOXB3_ENST00000476342.1_Silent_p.C117C|HOXB3_ENST00000472863.1_Silent_p.C44C|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Intron|HOXB3_ENST00000489475.1_Silent_p.C44C|HOXB3_ENST00000311626.4_Silent_p.C117C|HOXB3_ENST00000485909.2_Intron			P14651	HXB3_HUMAN	homeobox B3	117					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						TGCCGGGACCGCACTTTGGGG	0.617000													6	412					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42379590	42379590	+	Missense_Mutation	SNP	G	G	T			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr15:42379590G>T	ENST00000290472.3	-	3	257	c.163C>A	c.(163-165)Cct>Act	p.P55T		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	55	C2.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		TTCATTCCAGGTGCGGTCGAC	0.537000													14	194					0.00244969	0.00244969	1	1	0
PADI6	353238	broad.mit.edu	37	1	17721722	17721723	+	RNA	DEL	GA	GA	-	rs58784721		TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr1:17721722_17721723delGA	ENST00000434762.2	+	0	1545							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	tttgttttttgagagtcttgct	0.485													3	6	---	---	---	---					
ATP6V1C2	245973	broad.mit.edu	37	2	10917819	10917820	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr2:10917819_10917820delAG	ENST00000272238.4	+	11	1043_1044	c.934_935delAG	c.(934-936)afs	p.R312fs	ATP6V1C2_ENST00000381661.3_Intron	NM_001039362.1	NP_001034451.1	Q8NEY4	VATC2_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	312					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		GCAGACCGACAGAGAGAGAGAG	0.604													7	127	---	---	---	---					
ANKRD44	91526	broad.mit.edu	37	2	197943383	197943384	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr2:197943383_197943384delTG	ENST00000409153.1	-	16	1875_1876	c.1693_1694delCA	c.(1693-1695)tfs	p.H565fs	ANKRD44_ENST00000539527.1_Frame_Shift_Del_p.H493fs|ANKRD44_ENST00000337207.5_Intron|ANKRD44_ENST00000450567.1_Intron|ANKRD44_ENST00000328737.2_Intron|ANKRD44_ENST00000282272.8_Intron			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	811							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			ATTTGGGGTATGTGTGTGTGTG	0.411													4	7	---	---	---	---					
MAST4	375449	broad.mit.edu	37	5	66459102	66459121	+	Frame_Shift_Del	DEL	CGGAAGGCGAAAGTCCGCCG	CGGAAGGCGAAAGTCCGCCG	-			TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr5:66459102_66459121delCGGAAGGCGAAAGTCCGCCG	ENST00000404260.3	+	29	4412_4431	c.4104_4123delCGGAAGGCGAAAGTCCGCCG	c.(4102-4125)tcgcfs	p.SGRRKSAG1368fs	MAST4_ENST00000261569.7_Frame_Shift_Del_p.SGRRKSAG1171fs|MAST4_ENST00000405643.1_Frame_Shift_Del_p.SGRRKSAG1186fs|MAST4_ENST00000403625.2_Frame_Shift_Del_p.SGRRKSAG1365fs|MAST4_ENST00000403666.1_Frame_Shift_Del_p.SGRRKSAG1176fs			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1368						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GGTACCGGTCCGGAAGGCGAAAGTCCGCCGGCAACATCCC	0.677													20	114	---	---	---	---					
SFRP1	6422	broad.mit.edu	37	8	41166638	41166640	+	In_Frame_Del	DEL	GCT	GCT	-	rs3055861		TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr8:41166638_41166640delGCT	ENST00000220772.3	-	1	376_378	c.39_41delAGC	c.(37-42)gcc>gc	p.AA13del		NM_003012.4	NP_003003.3	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	13					brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			CACGCCCAGGGCTGCCCCGCGGC	0.764													9	3	---	---	---	---					
RP11-551L14.1	0	broad.mit.edu	37	12	31269189	31269190	+	RNA	INS	-	-	ATCAT	rs35880498		TCGA-KS-A41I-01A-11D-A23M-08	TCGA-KS-A41I-11A-11D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2141ba0-087c-4982-afda-8e955eb1a699	bb0aa13f-91b1-49bb-ab18-78372bf5d8ff	g.chr12:31269189_31269190insATCAT	ENST00000542490.1	-	0	165																				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(25)|prostate(3)|stomach(3)|urinary_tract(1)	41						CATGAGAACTCATTACCATGAT	0.351													3	3	---	---	---	---					
