Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTC36	143941	broad.mit.edu	37	11	118399446	118399446	+	Missense_Mutation	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr11:118399446G>A	ENST00000539546.1	+	3	405	c.70G>A	c.(70-72)Gag>Aag	p.E24K	RP11-770J1.3_ENST00000532597.1_RNA|RP11-770J1.3_ENST00000528578.1_RNA|RP11-770J1.3_ENST00000525992.2_RNA|RP11-770J1.3_ENST00000556583.1_RNA|TTC36_ENST00000302783.4_Missense_Mutation_p.E83K|RP11-770J1.3_ENST00000554407.1_RNA			A6NLP5	TTC36_HUMAN	tetratricopeptide repeat domain 36	83							binding			lung(2)	2						CCTGCTGCCTGAGAGGGCTTC	0.642000													18	49					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17272075	17272075	+	Missense_Mutation	SNP	G	G	A	rs2781608	by1000genomes	TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr1:17272075G>A	ENST00000375541.5	+	15	2179	c.2110G>A	c.(2110-2112)Gcc>Acc	p.A704T	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	704					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity	p.A704T(11)		breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GGCCGAGAAGGCCGAGGTGGC	0.657000													4	42					0	0	1	0	0
STOX2	56977	broad.mit.edu	37	4	184922519	184922519	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr4:184922519C>T	ENST00000308497.4	+	2	1643	c.208C>T	c.(208-210)Cag>Tag	p.Q70*	STOX2_ENST00000438269.1_Nonsense_Mutation_p.Q70*|STOX2_ENST00000511250.1_3'UTR	NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	70					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		CAGTCAGTCTCAGTTTATTCC	0.488000													15	36					0	0	1	0	0
MAP3K1	4214	broad.mit.edu	37	5	56178173	56178173	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr5:56178173C>G	ENST00000399503.3	+	14	3146	c.3146C>G	c.(3145-3147)tCa>tGa	p.S1049*		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	1049					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		TTTACTCAGTCAAGACCCTTG	0.438000													23	33					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198949565	198949565	+	Missense_Mutation	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr2:198949565G>A	ENST00000428675.1	+	2	1722	c.1324G>A	c.(1324-1326)Gtt>Att	p.V442I	PLCL1_ENST00000437704.2_Missense_Mutation_p.V344I	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	442	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	CTGTCGAAGCGTTGAACTCGA	0.408000													20	54					0	0	1	0	0
NDUFS2	4720	broad.mit.edu	37	1	161183498	161183498	+	Silent	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr1:161183498C>T	ENST00000392179.4	+	12	1511	c.1272C>T	c.(1270-1272)atC>atT	p.I424I	NDUFS2_ENST00000367993.3_Silent_p.I424I|NDUFS2_ENST00000465923.1_3'UTR	NM_001166159.1	NP_001159631.1	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	424					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	18	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	GATGCAAGATCAAGGCTCCTG	0.448000													48	160					0	0	1	0	0
RCAN1	1827	broad.mit.edu	37	21	35895881	35895881	+	Missense_Mutation	SNP	T	T	C			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr21:35895881T>C	ENST00000481448.1	-	3	836	c.350A>G	c.(349-351)cAt>cGt	p.H117R	RCAN1_ENST00000482533.1_5'UTR|RCAN1_ENST00000443408.2_5'UTR|RCAN1_ENST00000489903.1_5'UTR|RCAN1_ENST00000313806.4_Missense_Mutation_p.H127R|RCAN1_ENST00000487990.1_5'UTR|RCAN1_ENST00000381132.2_Missense_Mutation_p.H72R|RCAN1_ENST00000381135.3_Missense_Mutation_p.H117R|RCAN1_ENST00000399272.1_Missense_Mutation_p.H46R			P53805	RCAN1_HUMAN	regulator of calcineurin 1	127					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)	5						CTCAGTCTTATGCAGCTGGAG	0.458000													29	52					0	0	1	0	0
RBM22	55696	broad.mit.edu	37	5	150076426	150076426	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr5:150076426C>T	ENST00000199814.4	-	5	420	c.299G>A	c.(298-300)gGa>gAa	p.G100E	RBM22_ENST00000540000.1_Missense_Mutation_p.G51E|RBM22_ENST00000447771.2_Missense_Mutation_p.G51E	NM_018047.2	NP_060517.1	Q9NW64	RBM22_HUMAN	RNA binding motif protein 22	100					protein import into nucleus, translocation	catalytic step 2 spliceosome|cytoplasm	calcium-dependent protein binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(1)	17		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAAGACAATCCTGCGTCACG	0.388000													18	39					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713944	142713944	+	RNA	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr1:142713944C>T	ENST00000369381.2	-	0	661																											TGATTACCTCCGAAGTTAAAG	0.308000													7	29					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33612907	33612907	+	Missense_Mutation	SNP	G	G	C			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr11:33612907G>C	ENST00000321505.4	+	11	3980	c.3800G>C	c.(3799-3801)aGa>aCa	p.R1267T	KIAA1549L_ENST00000389726.3_Missense_Mutation_p.R1273T|KIAA1549L_ENST00000265654.5_Intron					KIAA1549-like																		CCTCAGGAAAGAGACGTCGCT	0.562000													24	37					0	0	1	0	0
SPOCK2	9806	broad.mit.edu	37	10	73826823	73826823	+	Silent	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr10:73826823G>A	ENST00000373109.2	-	8	1209	c.765C>T	c.(763-765)tcC>tcT	p.S255S	SPOCK2_ENST00000460053.1_5'UTR|SPOCK2_ENST00000317376.4_Silent_p.S255S|SPOCK2_ENST00000536168.1_Silent_p.S255S	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	255					extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						TGTCCAGCTTGGAGAACATCC	0.577000													21	50					0	0	1	0	0
PLEKHH3	79990	broad.mit.edu	37	17	40822615	40822615	+	Silent	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr17:40822615G>A	ENST00000293349.6	-	10	1951	c.1521C>T	c.(1519-1521)caC>caT	p.H507H	PLEKHH3_ENST00000591022.1_Silent_p.H510H|PLEKHH3_ENST00000412503.1_Silent_p.H507H|PLEKHH3_ENST00000456950.2_5'UTR			Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 3	510	FERM.				signal transduction	cytoskeleton				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|skin(2)	13		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		AAGGCAGTTCGTGACCGTCTG	0.612000													30	41					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76735311	76735311	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr10:76735311C>T	ENST00000287239.4	+	8	1705	c.1216C>T	c.(1216-1218)Cgg>Tgg	p.R406W	KAT6B_ENST00000372725.1_Intron|KAT6B_ENST00000372724.1_Intron|KAT6B_ENST00000372711.1_Missense_Mutation_p.R406W|KAT6B_ENST00000372714.1_Intron	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	406	Negatively regulates HAT activity.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										AGACCCCACTCGGCCTGGTGC	0.493000													15	56					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12816128	12816128	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr19:12816128C>T	ENST00000425528.1	-	18	2305	c.1948G>A	c.(1948-1950)Gag>Aag	p.E650K	TNPO2_ENST00000450764.2_Missense_Mutation_p.E650K|TNPO2_ENST00000356861.5_Missense_Mutation_p.E650K|TNPO2_ENST00000588216.1_Missense_Mutation_p.E650K|TNPO2_ENST00000592287.1_Missense_Mutation_p.E650K|TNPO2_ENST00000441499.1_Missense_Mutation_p.E650K			O14787	TNPO2_HUMAN	transportin 2	650					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity	p.E650*(2)		autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CCCAGGCCCTCGGCCAGGCCG	0.602000													9	4					0	0	1	0	0
ALDH2	217	broad.mit.edu	37	12	112230404	112230404	+	Missense_Mutation	SNP	G	G	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr12:112230404G>T	ENST00000261733.2	+	9	962	c.901G>T	c.(901-903)Gat>Tat	p.D301Y	ALDH2_ENST00000416293.3_Missense_Mutation_p.D254Y	NM_000690.3	NP_000681.2	P05091	ALDH2_HUMAN	aldehyde dehydrogenase 2 family (mitochondrial)	301					carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity|electron carrier activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|stomach(1)	22					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)	TCCCGCAGTGGATTGGGCCGT	0.622000			T	HMGA2	leiomyoma								9	17					2.27111e-07	2.34942e-07	1	1	0
LLGL1	3996	broad.mit.edu	37	17	18145214	18145214	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr17:18145214C>T	ENST00000316843.4	+	19	2879	c.2783C>T	c.(2782-2784)tCc>tTc	p.S928F		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	928					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					TACCTGATATCCCCATCAGAA	0.577000													26	106					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90349724	90349724	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr15:90349724C>T	ENST00000300060.6	-	2	404	c.91G>A	c.(91-93)Gtg>Atg	p.V31M		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	31					angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GAGTACACCACTGACAGTGCG	0.627000													34	63					0	0	1	0	0
ZNF106	64397	broad.mit.edu	37	15	42740457	42740457	+	Missense_Mutation	SNP	C	C	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr15:42740457C>G	ENST00000263805.4	-	3	3205	c.2879G>C	c.(2878-2880)aGg>aCg	p.R960T	ZNF106_ENST00000565611.1_Missense_Mutation_p.R145T|ZNF106_ENST00000565380.1_Missense_Mutation_p.R188T	NM_022473.1	NP_071918.1			zinc finger protein 106																		TGGTATAGACCTCTCCTGGCT	0.458000													61	89					0	0	1	0	0
EIF3F	8665	broad.mit.edu	37	11	8013700	8013700	+	Missense_Mutation	SNP	A	A	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr11:8013700A>G	ENST00000533626.1	+	5	1131	c.505A>G	c.(505-507)Atc>Gtc	p.I169V	EIF3F_ENST00000449102.2_Missense_Mutation_p.I20V|EIF3F_ENST00000537635.1_Missense_Mutation_p.I184V|EIF3F_ENST00000309828.4_Missense_Mutation_p.I169V			O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3, subunit F	169	MPN.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)	13				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAATGAGCTCATCCTGGGCTG	0.463000													17	26					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	12814	12814	+	Missense_Mutation	SNP	G	G	C			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chrM:12814G>C	ENST00000361567.2	+	1	478	c.478G>C	c.(478-480)Gcc>Ccc	p.A160P				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	160			A -> V.		mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	GTTGATGATACGCCCGAGCAG	0.453000													18	83					0	0	1	0	0
HIST1H3H	8357	broad.mit.edu	37	6	27778092	27778092	+	Missense_Mutation	SNP	A	A	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr6:27778092A>G	ENST00000369163.2	+	1	251	c.241A>G	c.(241-243)Acc>Gcc	p.T81A		NM_003536.2	NP_003527.1	P68431	H31_HUMAN	histone cluster 1, H3h	81					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)|upper_aerodigestive_tract(3)	10						GGACTTCAAGACCGACTTGCG	0.612000													22	30					0	0	1	0	0
MEOX2	4223	broad.mit.edu	37	7	15725715	15725715	+	Missense_Mutation	SNP	G	G	C			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr7:15725715G>C	ENST00000262041.5	-	1	722	c.313C>G	c.(313-315)Cgg>Ggg	p.R105G		NM_005924.4	NP_005915.2	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	105					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		AGGCTGTGCCGAGCCGCACTC	0.662000													6	10					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52233422	52233422	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr8:52233422C>T	ENST00000543296.1	-	20	4037	c.3937G>A	c.(3937-3939)Gtg>Atg	p.V1313M	PXDNL_ENST00000356297.4_Silent_p.G1394G|RP11-401H2.1_ENST00000521294.1_RNA			A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	0					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CATCTGTACACCCTGCCTGCC	0.502000													43	63					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11457095	11457095	+	Silent	SNP	T	T	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr7:11457095T>A	ENST00000423059.3	-	17	3770	c.3519A>T	c.(3517-3519)ccA>ccT	p.P1173P	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1173	TSP type-1 11.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		ATTGGGTCCATGGACCCCATT	0.388000										HNSCC(18;0.044)			3	20					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63908060	63908060	+	Silent	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr15:63908060G>A	ENST00000443617.2	-	76	14088	c.14001C>T	c.(13999-14001)atC>atT	p.I4667I		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4667	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TTCCACCAGGGATTATAGGAA	0.403000													4	10					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58349367	58349367	+	Silent	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr20:58349367C>T	ENST00000371015.1	+	7	1463	c.996C>T	c.(994-996)agC>agT	p.S332S	PHACTR3_ENST00000541461.1_Silent_p.S291S|PHACTR3_ENST00000355648.4_Silent_p.S291S|PHACTR3_ENST00000395636.2_Silent_p.S291S|PHACTR3_ENST00000395639.4_Silent_p.S221S|PHACTR3_ENST00000361300.4_Silent_p.S221S|PHACTR3_ENST00000359926.3_Silent_p.S329S	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	332						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GAACGTCCAGCGTGGAGCGGG	0.522000													27	43					0	0	1	0	0
C2orf15	150590	broad.mit.edu	37	2	99767011	99767011	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr2:99767011C>G	ENST00000302513.2	+	4	728	c.92C>G	c.(91-93)tCa>tGa	p.S31*	TSGA10_ENST00000393483.3_Intron|C2orf15_ENST00000409684.1_Nonsense_Mutation_p.S31*	NM_144706.2	NP_653307.1	Q8WU43	CB015_HUMAN	chromosome 2 open reading frame 15	31										autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(1)	6						CACATTTGTTCAGCTATCCTA	0.333000													27	55					0	0	1	0	0
ARPC1B	10095	broad.mit.edu	37	7	98984314	98984314	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr7:98984314C>T	ENST00000451682.1	+	5	380	c.71C>T	c.(70-72)gCc>gTc	p.A24V	ARPC1A_ENST00000432884.2_Silent_p.C339C|ARPC1B_ENST00000252725.5_Missense_Mutation_p.A24V|ARPC1B_ENST00000474880.1_3'UTR			O15143	ARC1B_HUMAN	actin related protein 2/3 complex, subunit 1B, 41kDa	24					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(2)|lung(1)	11	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCAGAGATTGCCATCTGCCCC	0.557000													4	150					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48125076	48125076	+	Silent	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr16:48125076C>T	ENST00000311303.3	-	23	3585	c.3240G>A	c.(3238-3240)acG>acA	p.T1080T	ABCC12_ENST00000448542.1_3'UTR|ABCC12_ENST00000416054.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	1080	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				ATTTGGCTTGCGTCTCTGTTC	0.532000													72	121					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216226297	216226297	+	Missense_Mutation	SNP	C	C	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr2:216226297C>A	ENST00000354785.4	-	46	7784	c.7415G>T	c.(7414-7416)aGa>aTa	p.R2472I	FN1_ENST00000446046.1_Missense_Mutation_p.R2325I|FN1_ENST00000443816.1_Missense_Mutation_p.R2260I|FN1_ENST00000432072.2_Missense_Mutation_p.R2262I|FN1_ENST00000421182.1_Missense_Mutation_p.R2235I|FN1_ENST00000359671.1_Missense_Mutation_p.R2381I|FN1_ENST00000357867.4_Missense_Mutation_p.R2171I|FN1_ENST00000357009.2_3'UTR|FN1_ENST00000356005.4_Missense_Mutation_p.R2291I|FN1_ENST00000346544.3_Missense_Mutation_p.R2206I|FN1_ENST00000345488.5_Missense_Mutation_p.R2179I|FN1_ENST00000336916.4_Missense_Mutation_p.R2350I|FN1_ENST00000323926.6_Missense_Mutation_p.R2441I			P02751	FINC_HUMAN	fibronectin 1	2381					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGAATCTTCTCTGTCAGCCTG	0.398000													35	81					2.20474e-14	2.30728e-14	1	1	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				24	50					0	0	1	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240809	39240809	+	Silent	SNP	C	C	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr17:39240809C>A	ENST00000391417.4	+	1	351	c.351C>A	c.(349-351)ccC>ccA	p.P117P		NM_033061.3	NP_149050.3			keratin associated protein 4-7											NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						gctgccgcccctgctgctgcC	0.672000													3	31					0.115264	0.115264	1	1	0
RPL32P3	0	broad.mit.edu	37	3	129116038	129116038	+	RNA	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr3:129116038C>T	ENST00000514355.1	-	0	412																				lung(1)	1						GAGGCTTTCCCGCCCAGGGAC	0.567000													4	105					0	0	1	0	0
SPG20	23111	broad.mit.edu	37	13	36905542	36905542	+	Silent	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr13:36905542C>T	ENST00000451493.1	-	3	1219	c.1002G>A	c.(1000-1002)cgG>cgA	p.R334R	SPG20_ENST00000495510.1_5'UTR|SPG20_ENST00000355182.4_Silent_p.R334R|SPG20_ENST00000494062.2_Silent_p.R334R|SPG20_ENST00000438666.2_Silent_p.R334R	NM_001142295.1	NP_001135767.1	Q8N0X7	SPG20_HUMAN	spastic paraplegia 20 (Troyer syndrome)	334					cell death	cytoplasm	ubiquitin protein ligase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	27		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		TTACCTGGAGCCGAAGGTCAG	0.418000													29	45					0	0	1	0	0
GDI2	2665	broad.mit.edu	37	10	5842629	5842629	+	Missense_Mutation	SNP	T	T	C			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr10:5842629T>C	ENST00000380191.4	-	2	375	c.85A>G	c.(85-87)Aaa>Gaa	p.K29E	GDI2_ENST00000380132.4_Missense_Mutation_p.K33E|GDI2_ENST00000380181.3_Missense_Mutation_p.K29E	NM_001115156.1|NM_001494.3	NP_001108628.1|NP_001485.2	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2	29					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity			NS(1)|breast(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10						TGAAGAACTTTCTTGCCATTC	0.363000													33	67					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													3	23					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106967568	106967568	+	Missense_Mutation	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr6:106967568G>A	ENST00000369066.3	+	2	1748	c.1261G>A	c.(1261-1263)Gaa>Aaa	p.E421K		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	421							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CCTTGTACTTGAAAATGTAAC	0.473000													18	51					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13753238	13753238	+	Silent	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr20:13753238C>T	ENST00000202816.1	-	5	1280	c.1173G>A	c.(1171-1173)aaG>aaA	p.K391K		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TCATCCTCTCCTTTCCAAATT	0.353000													12	77					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102304772	102304772	+	RNA	SNP	T	T	C			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr15:102304772T>C	ENST00000561463.1	+	0	12818																											CACAGCGGCGTGACGAGACTC	0.587000													3	33					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125175105	125175105	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr2:125175105C>T	ENST00000431078.1	+	4	831	c.467C>T	c.(466-468)cCc>cTc	p.P156L		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	156	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CGCTTTGTGCCCCTGGAATGG	0.488000													7	17					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132231901	132231901	+	Silent	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr3:132231901C>T	ENST00000260818.6	+	45	5591	c.5343C>T	c.(5341-5343)ctC>ctT	p.L1781L		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1781							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						TTTCTCTTCTCCGAGTTCATG	0.383000													18	50					0	0	1	0	0
CNNM1	26507	broad.mit.edu	37	10	101090713	101090713	+	Missense_Mutation	SNP	G	G	C			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr10:101090713G>C	ENST00000356713.4	+	1	1858	c.1569G>C	c.(1567-1569)aaG>aaC	p.K523N	CNNM1_ENST00000370528.3_Missense_Mutation_p.K452N|CNNM1_ENST00000370534.4_Missense_Mutation_p.K158N|CNNM1_ENST00000446890.1_Missense_Mutation_p.K452N	NM_020348.2	NP_065081.2	Q9NRU3	CNNM1_HUMAN	cyclin M1	523	CBS 2.				ion transport	integral to membrane|plasma membrane				NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(5)|ovary(1)|prostate(1)|skin(1)	25		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		AGGAGTTTAAGAAGGGTGAGC	0.517000													32	49					0	0	1	0	0
FUT4	2526	broad.mit.edu	37	11	94277440	94277440	+	Silent	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr11:94277440G>A	ENST00000358752.2	+	1	424	c.141G>A	c.(139-141)gtG>gtA	p.V47V		NM_002033.3	NP_002024.1	P22083	FUT4_HUMAN	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	47					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			central_nervous_system(2)|endometrium(2)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GACGGGCGGTGCCCGGTTGGG	0.761000													13	13					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237794725	237794725	+	Splice_Site	SNP	A	A	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr1:237794725A>G	ENST00000366574.2	+	42	6757		c.e42-1		RYR2_ENST00000360064.6_Splice_Site|RYR2_ENST00000542537.1_Splice_Site	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTCCTTTCTAGGGATATTAT	0.403000													22	17					0	0	1	0	0
MTF1	4520	broad.mit.edu	37	1	38280866	38280866	+	Missense_Mutation	SNP	A	A	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr1:38280866A>G	ENST00000373036.4	-	11	2344	c.2204T>C	c.(2203-2205)aTt>aCt	p.I735T		NM_005955.2	NP_005946.2	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	735						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			endometrium(3)|kidney(5)|large_intestine(6)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)	31	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TAGTGCTTCAATGGGAATCAG	0.552000													32	45					0	0	1	0	0
HTRA2	27429	broad.mit.edu	37	2	74757203	74757203	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr2:74757203C>T	ENST00000258080.3	+	1	700	c.70C>T	c.(70-72)Cgc>Tgc	p.R24C	HTRA2_ENST00000352222.3_Missense_Mutation_p.R24C|HTRA2_ENST00000467961.1_Intron	NM_013247.4	NP_037379.1	O43464	HTRA2_HUMAN	HtrA serine peptidase 2	24					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding	p.R24C(1)		endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	12						GGGGGGCATTCGCTGGGGGAG	0.711000													20	40					0	0	1	0	0
ALKBH6	84964	broad.mit.edu	37	19	36501939	36501939	+	Missense_Mutation	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr19:36501939G>A	ENST00000486389.1	-	4	872	c.124C>T	c.(124-126)Cct>Tct	p.P42S	ALKBH6_ENST00000485128.1_Missense_Mutation_p.P65S|ALKBH6_ENST00000378875.3_Missense_Mutation_p.P93S|AC002116.8_ENST00000473572.2_RNA|ALKBH6_ENST00000252984.7_Missense_Mutation_p.P65S|ALKBH6_ENST00000495116.2_Intron			Q3KRA9	ALKB6_HUMAN	alkB, alkylation repair homolog 6 (E. coli)	65						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|skin(1)	9	all_lung(56;1.35e-06)|Lung NSC(56;2.15e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CGGGGATGAGGAAGCCCACCT	0.602000													9	14					0	0	1	0	0
SPOCK2	9806	broad.mit.edu	37	10	73826824	73826824	+	Missense_Mutation	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr10:73826824G>A	ENST00000373109.2	-	8	1208	c.764C>T	c.(763-765)tCc>tTc	p.S255F	SPOCK2_ENST00000460053.1_5'UTR|SPOCK2_ENST00000317376.4_Missense_Mutation_p.S255F|SPOCK2_ENST00000536168.1_Missense_Mutation_p.S255F	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	255					extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						GTCCAGCTTGGAGAACATCCA	0.582000													22	51					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216226313	216226313	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr2:216226313C>T	ENST00000354785.4	-	46	7768	c.7399G>A	c.(7399-7401)Gat>Aat	p.D2467N	FN1_ENST00000446046.1_Missense_Mutation_p.D2320N|FN1_ENST00000443816.1_Missense_Mutation_p.D2255N|FN1_ENST00000432072.2_Missense_Mutation_p.D2257N|FN1_ENST00000421182.1_Missense_Mutation_p.D2230N|FN1_ENST00000359671.1_Missense_Mutation_p.D2376N|FN1_ENST00000357867.4_Missense_Mutation_p.D2166N|FN1_ENST00000357009.2_3'UTR|FN1_ENST00000356005.4_Missense_Mutation_p.D2286N|FN1_ENST00000346544.3_Missense_Mutation_p.D2201N|FN1_ENST00000345488.5_Missense_Mutation_p.D2174N|FN1_ENST00000336916.4_Missense_Mutation_p.D2345N|FN1_ENST00000323926.6_Missense_Mutation_p.D2436N			P02751	FINC_HUMAN	fibronectin 1	2376					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCCTGTACATCTAAAGGCATG	0.373000													35	77					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27382395	27382395	+	Missense_Mutation	SNP	A	A	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr10:27382395A>T	ENST00000376087.4	-	3	579	c.414T>A	c.(412-414)gaT>gaA	p.D138E	ANKRD26_ENST00000436985.2_Missense_Mutation_p.D138E	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	138						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						CAAGATTTGGATCAGCACCAT	0.408000													28	67					0	0	1	0	0
C10orf2	56652	broad.mit.edu	37	10	102749139	102749139	+	Missense_Mutation	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr10:102749139G>A	ENST00000370228.1	+	1	1357	c.1172G>A	c.(1171-1173)cGc>cAc	p.R391H	C10orf2_ENST00000473656.1_Intron|C10orf2_ENST00000311916.2_Missense_Mutation_p.R391H	NM_001163812.1|NM_001163814.1	NP_001157284.1|NP_001157286.1	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	391	SF4 helicase.				cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GCTGGCCTCCGCTGGAGCCGC	0.552000													44	66					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1811611	1811611	+	Missense_Mutation	SNP	C	C	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr19:1811611C>G	ENST00000539485.1	-	2	358	c.125G>C	c.(124-126)gGc>gCc	p.G42A	ATP8B3_ENST00000525591.1_5'UTR|ATP8B3_ENST00000526092.1_5'UTR|ATP8B3_ENST00000310127.6_Missense_Mutation_p.G42A			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	42					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGCGGATGCCAGCAGGACC	0.677000													8	23					0	0	1	0	0
KANSL2	54934	broad.mit.edu	37	12	49054304	49054304	+	Missense_Mutation	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr12:49054304G>A	ENST00000550347.1	-	7	1664	c.1621C>T	c.(1621-1623)Ccc>Tcc	p.P541S	KANSL2_ENST00000420613.2_Missense_Mutation_p.P358S|KANSL2_ENST00000553086.1_Missense_Mutation_p.P358S|KANSL2_ENST00000548701.1_5'UTR			Q9H9L4	CL041_HUMAN	KAT8 regulatory NSL complex subunit 2	358																	GGGCAGCAGGGATCCTCAGAG	0.522000													15	17					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100523650	100523650	+	Missense_Mutation	SNP	A	A	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr8:100523650A>T	ENST00000358544.2	+	29	4729	c.4618A>T	c.(4618-4620)Aca>Tca	p.T1540S	VPS13B_ENST00000357162.2_Missense_Mutation_p.T1515S|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1540					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCATACACTGACATCCCGCAA	0.363000													23	25					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14862664	14862664	+	Missense_Mutation	SNP	G	G	C			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr3:14862664G>C	ENST00000285046.5	+	1	2196	c.2086G>C	c.(2086-2088)Gac>Cac	p.D696H	FGD5_ENST00000543601.1_Missense_Mutation_p.D455H	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	696					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						TCTGGAAGTTGACCGGAGAAG	0.527000													15	31					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11832	11832	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chrM:11832G>A	ENST00000361381.2	+	1	1073	c.1073G>A	c.(1072-1074)tGa>tAa	p.358_358ins*						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						AATAGCTTTTTGATGACTTCT	0.443000													86	3					0	0	1	0	0
EXOSC10	5394	broad.mit.edu	37	1	11155844	11155844	+	Missense_Mutation	SNP	C	C	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr1:11155844C>G	ENST00000544779.1	-	3	348	c.343G>C	c.(343-345)Gat>Cat	p.D115H	EXOSC10_ENST00000304457.7_Missense_Mutation_p.D115H|EXOSC10_ENST00000376936.4_Missense_Mutation_p.D115H			Q01780	EXOSX_HUMAN	exosome component 10	115					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		TCATTGGCATCAACTAGTAAA	0.423000													43	97					0	0	1	0	0
TBR1	10716	broad.mit.edu	37	2	162274722	162274722	+	Silent	SNP	C	C	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr2:162274722C>G	ENST00000389554.3	+	3	1175	c.858C>G	c.(856-858)gtC>gtG	p.V286V	TBR1_ENST00000410035.1_5'UTR	NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	286						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						GAAATCGGGTCTATATGCATC	0.463000													15	31					0	0	1	0	0
NKAPP1	0	broad.mit.edu	37	X	119374187	119374187	+	RNA	SNP	G	G	C			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chrX:119374187G>C	ENST00000592037.1	-	0	4888																											CCTTTCACTTGAATGACTAGA	0.269000													9	14					0	0	1	0	0
ECHS1	1892	broad.mit.edu	37	10	135179592	135179592	+	Silent	SNP	G	G	C			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr10:135179592G>C	ENST00000368547.3	-	6	982	c.627C>G	c.(625-627)gtC>gtG	p.V209V		NM_004092.3	NP_004083.3	P30084	ECHM_HUMAN	enoyl CoA hydratase, short chain, 1, mitochondrial	209					fatty acid beta-oxidation	mitochondrial matrix	enoyl-CoA hydratase activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|skin(1)	10		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;1.62e-06)|OV - Ovarian serous cystadenocarcinoma(35;5.75e-06)|Epithelial(32;7.58e-06)		AAATCTTGCTGACAAGACCTG	0.478000													27	39					0	0	1	0	0
H1FX	8971	broad.mit.edu	37	3	129034703	129034703	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr3:129034703C>T	ENST00000333762.4	-	1	417	c.43G>A	c.(43-45)Gag>Aag	p.E15K	H1FX-AS1_ENST00000511998.1_RNA|H1FX-AS1_ENST00000433902.2_RNA	NM_006026.3	NP_006017.1	Q92522	H1X_HUMAN	H1 histone family, member X	15					nucleosome assembly	nucleosome|nucleus	DNA binding			kidney(1)|ovary(1)|urinary_tract(2)	4						GCCATTCCCTCGGCGGTCGTC	0.652000													3	9					0	0	1	0	0
STXBP3	6814	broad.mit.edu	37	1	109337503	109337503	+	Missense_Mutation	SNP	A	A	G			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr1:109337503A>G	ENST00000370008.3	+	13	1134	c.1084A>G	c.(1084-1086)Ata>Gta	p.I362V		NM_007269.2	NP_009200.2	O00186	STXB3_HUMAN	syntaxin binding protein 3	362					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(3)|urinary_tract(1)	13		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		CAAGCTTAATATAGAAAAGCT	0.313000													21	41					0	0	1	0	0
INCENP	3619	broad.mit.edu	37	11	61895702	61895702	+	Silent	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr11:61895702C>T	ENST00000394818.3	+	2	271	c.69C>T	c.(67-69)ctC>ctT	p.L23L	INCENP_ENST00000278849.4_Silent_p.L23L	NM_001040694.1	NP_001035784.1	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	23					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TGGAGTTTCTCTGCAACATGG	0.567000													21	34					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36253804	36253804	+	Missense_Mutation	SNP	A	A	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr5:36253804A>T	ENST00000296604.3	-	12	1597	c.1112T>A	c.(1111-1113)gTa>gAa	p.V371E	RANBP3L_ENST00000502994.1_Missense_Mutation_p.V396E	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	371	RanBD1.				intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TGTTATTCGTACATTTTTGTG	0.348000													19	44					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38944564	38944564	+	Missense_Mutation	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr5:38944564C>T	ENST00000357387.3	-	36	4927	c.4897G>A	c.(4897-4899)Gag>Aag	p.E1633K	RICTOR_ENST00000296782.5_Missense_Mutation_p.E1657K	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1633					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding	p.E1633Q(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					AGCCCAGTCTCATGACATTTA	0.323000													58	152					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr9:21971120G>A	ENST00000304494.5	-	2	508	c.238C>T	c.(238-240)Cga>Tga	p.R80*	CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.R80*|CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.R80*|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000579755.1_Missense_Mutation_p.P94L|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.R29*|CDKN2A_ENST00000361570.3_Missense_Mutation_p.P135L|CDKN2A_ENST00000530628.2_Missense_Mutation_p.P94L	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	80			R -> L (in a head and neck tumor).|R -> P (in CMM2; loss of CDK4 binding).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.R80*(100)|p.?(44)|p.P135L(7)|p.L65fs*38(1)|p.T79fs*37(1)|p.0(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726000	R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)|R80*(MEWO_SKIN)	17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	18					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr16:90161902A>G	ENST00000567960.1	+	0	638				TUBB8P7_ENST00000564451.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													3	43					0	0	1	0	0
SPOCK2	9806	broad.mit.edu	37	10	73826826	73826826	+	Silent	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr10:73826826G>A	ENST00000373109.2	-	8	1206	c.762C>T	c.(760-762)ttC>ttT	p.F254F	SPOCK2_ENST00000460053.1_5'UTR|SPOCK2_ENST00000317376.4_Silent_p.F254F|SPOCK2_ENST00000536168.1_Silent_p.F254F	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	254					extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						CCAGCTTGGAGAACATCCAGC	0.577000													20	51					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839704	62839704	+	Silent	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr20:62839704C>T	ENST00000536311.1	+	7	1519	c.1155C>T	c.(1153-1155)atC>atT	p.I385I	MYT1_ENST00000360149.4_Intron|MYT1_ENST00000328439.1_Silent_p.I385I			Q01538	MYT1_HUMAN	myelin transcription factor 1	385					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGCAGGCCATCGCCCTGAAGG	0.657000													22	40					0	0	1	0	0
NPIPB15	440348	broad.mit.edu	37	16	74425609	74425609	+	Missense_Mutation	SNP	C	C	G	rs710958		TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr16:74425609C>G	ENST00000429990.1	+	7	1059	c.963C>G	c.(961-963)gaC>gaG	p.D321E						nuclear pore complex interacting protein family, member B15																		ATCTGAAGGACTGTCTCTTTG	0.522000													4	132					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84519424	84519424	+	Missense_Mutation	SNP	G	G	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chrX:84519424G>A	ENST00000360700.4	+	5	1652	c.766G>A	c.(766-768)Gat>Aat	p.D256N	ZNF711_ENST00000276123.3_Missense_Mutation_p.D256N|ZNF711_ENST00000395402.1_Missense_Mutation_p.D234N|ZNF711_ENST00000373165.3_Missense_Mutation_p.D256N|ZNF711_ENST00000542798.1_Missense_Mutation_p.D52N			Q9Y462	ZN711_HUMAN	zinc finger protein 711	256					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						GGCTGAAGATGATGTTGAAAT	0.308000													14	24					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34140563	34140563	+	Silent	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr15:34140563C>T	ENST00000389232.4	+	94	13639	c.13569C>T	c.(13567-13569)acC>acT	p.T4523T	RYR3_ENST00000415757.3_Silent_p.T4518T|RYR3_ENST00000559917.1_3'UTR	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	4523					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TATATATCACCGAACAGCCAT	0.502000													22	71					0	0	1	0	0
DNAJC3	5611	broad.mit.edu	37	13	96439369	96439369	+	Silent	SNP	C	C	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr13:96439369C>T	ENST00000602402.1	+	11	1434	c.1317C>T	c.(1315-1317)ttC>ttT	p.F439F	DNAJC3_ENST00000376795.6_Silent_p.F388F	NM_006260.4	NP_006251.1	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	439	J.				protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding			NS(1)|breast(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			AGAAAAAGTTCATTGATATAG	0.383000													33	70					0	0	1	0	0
GBE1	2632	broad.mit.edu	37	3	81754624	81754624	+	Missense_Mutation	SNP	G	G	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr3:81754624G>T	ENST00000429644.2	-	2	927	c.284C>A	c.(283-285)gCa>gAa	p.A95E	GBE1_ENST00000489715.1_Missense_Mutation_p.A54E	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	95					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		AACTCCTTCTGCTCCCGGGGC	0.343000									Glycogen Storage Disease, type IV				3	5					0.115264	0.115264	1	1	0
CROCCP2	0	broad.mit.edu	37	1	16948832	16948833	+	RNA	INS	-	-	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr1:16948832_16948833insA	ENST00000412962.1	-	0	1000																											tgcctacctagaatggcattaa	0.520													2	4	---	---	---	---					
RPTN	126638	broad.mit.edu	37	1	152127881	152127884	+	Frame_Shift_Del	DEL	TGTC	TGTC	-			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr1:152127881_152127884delTGTC	ENST00000316073.3	-	3	1755_1758	c.1691_1694delGACA	c.(1690-1695)aafs	p.RQ564fs		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	564	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						GCTCTGGCCTTGTCTGTCTGTCTG	0.485													8	998	---	---	---	---					
CCDC110	256309	broad.mit.edu	37	4	186366679	186366680	+	Frame_Shift_Ins	INS	-	-	T			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr4:186366679_186366680insT	ENST00000307588.3	-	7	2553_2554	c.2478_2479insA	c.(2476-2481)aaacagfs	p.Q827fs	C4orf47_ENST00000378850.4_Intron|CCDC110_ENST00000393540.3_Frame_Shift_Ins_p.Q790fs	NM_152775.3	NP_689988.1	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110	827						nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(9)	30		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		AGAGTTCTGTCTTTAACTTTGA	0.302													21	48	---	---	---	---					
MDC1	9656	broad.mit.edu	37	6	30671451	30671452	+	Frame_Shift_Del	DEL	CT	CT	-	rs77465266	byFrequency	TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr6:30671451_30671452delCT	ENST00000376406.3	-	10	6155_6156	c.5508_5509delAG	c.(5506-5511)actgfs	p.TV1836fs	MDC1_ENST00000376405.2_Frame_Shift_Del_p.TV1572fs|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1836	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TTGATAATCACTGTCTTCTGGG	0.505								Other conserved DNA damage response genes					61	99	---	---	---	---					
POLR2J4	0	broad.mit.edu	37	7	44001630	44001631	+	RNA	INS	-	-	A			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr7:44001630_44001631insA	ENST00000427076.1	-	0	1485_1486					NR_003655.2																						GTAGTAGCTGGAGGGCAGCACC	0.668													2	4	---	---	---	---					
SPATA31D5P	0	broad.mit.edu	37	9	84528612	84528614	+	RNA	DEL	TTG	TTG	-			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr9:84528612_84528614delTTG	ENST00000527857.1	+	0	221					NR_026851.1																						AGATTCCCTCTTGTTGTTTCCCA	0.389													6	2	---	---	---	---					
ARID2	196528	broad.mit.edu	37	12	46215248	46215257	+	Frame_Shift_Del	DEL	AGACTGATAG	AGACTGATAG	-			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr12:46215248_46215257delAGACTGATAG	ENST00000334344.6	+	6	855_864	c.683_692delAGACTGATAG	c.(682-693)aafs	p.KTDR228fs	ARID2_ENST00000422737.1_Frame_Shift_Del_p.KTDR79fs	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	228					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TGGAAAGAGAAGACTGATAGAGACTTCGTT	0.281			"""N, S, F"""		hepatocellular carcinoma								9	60	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102296030	102296032	+	RNA	DEL	CTC	CTC	-			TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr15:102296030_102296032delCTC	ENST00000561463.1	+	0	4076_4078																											AGTTCATCTTCTCGGAGCTGCTG	0.596													2	4	---	---	---	---					
RRN3P2	0	broad.mit.edu	37	16	29113498	29113498	+	RNA	DEL	T	T	-	rs11366120		TCGA-4C-A93U-01A-11D-A397-08	TCGA-4C-A93U-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8c040cc-1df1-4452-883b-be129a96e900	c986caeb-185d-46b6-97b7-444b7f6c3095	g.chr16:29113498delT	ENST00000564580.1	+	0	1360																											AGGAGGTGGAttttttttttc	0.542													4	7	---	---	---	---					
