Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIF21B	23046	broad.mit.edu	37	1	200944674	200944674	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr1:200944674C>T	ENST00000332129.2	-	32	4844	c.4528G>A	c.(4528-4530)Gat>Aat	p.D1510N	KIF21B_ENST00000360529.5_Missense_Mutation_p.D1510N|KIF21B_ENST00000422435.2_Missense_Mutation_p.D1523N|KIF21B_ENST00000461742.2_Missense_Mutation_p.D1523N	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1523					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						ATGCCGTTATCTCGGGAGCCA	0.597000													31	37					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16956406	16956406	+	RNA	SNP	G	G	T			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr1:16956406G>T	ENST00000412962.1	-	0	294																											tgatctgcacgcctcggcctc	0.478000													3	4					0.115264	0.121668	1	1	0
GIF	2694	broad.mit.edu	37	11	59608637	59608637	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr11:59608637G>C	ENST00000541311.1	-	5	831	c.597C>G	c.(595-597)taC>taG	p.Y199*	GIF_ENST00000257248.2_Nonsense_Mutation_p.Y224*			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	224					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						GGCCAGTACTGTAGATGTCTC	0.468000													10	91					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274214	39274214	+	Missense_Mutation	SNP	G	G	C			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr17:39274214G>C	ENST00000391413.2	-	1	392	c.354C>G	c.(352-354)agC>agG	p.S118R		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	118	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			gtctgcagcagctggacacac	0.652000													4	51					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16946393	16946393	+	RNA	SNP	G	G	A			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr1:16946393G>A	ENST00000412962.1	-	0	1126																											TCCTGCTGCAGGGCAGCAATC	0.662000													11	19					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75406952	75406952	+	Missense_Mutation	SNP	A	A	G			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr10:75406952A>G	ENST00000394810.2	-	4	2607	c.2458T>C	c.(2458-2460)Ttt>Ctt	p.F820L	SYNPO2L_ENST00000372872.4_Intron|SYNPO2L_ENST00000372873.4_Missense_Mutation_p.F596L	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	820	Pro-rich.					cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					TGGGGGAAAAAGGGAGAGAGC	0.577000													4	152					0	0	1	0	0
LILRB5	0	broad.mit.edu	37	19	54754901	54754901	+	Silent	SNP	T	T	C			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr19:54754901T>C	ENST00000450632.1	-	13	1811	c.1734A>G	c.(1732-1734)gcA>gcG	p.A578A	LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000449561.2_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	378					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGTCCTCTTCTGCCTGTCTGT	0.587000													5	39					0	0	1	0	0
LILRB5	0	broad.mit.edu	37	19	54754889	54754889	+	Silent	SNP	T	T	C			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr19:54754889T>C	ENST00000450632.1	-	13	1823	c.1746A>G	c.(1744-1746)agA>agG	p.R582R	LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000449561.2_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	388					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGTCCATCTGTCTGTCCTCTT	0.597000													5	44					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109795455	109795455	+	Silent	SNP	C	C	T			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr1:109795455C>T	ENST00000271332.3	+	1	2815	c.2754C>T	c.(2752-2754)ccC>ccT	p.P918P		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	918	Cadherin 7.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		ATGACAATCCCCCTGTCTTTG	0.562000													7	97					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406191	55406191	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr11:55406191C>T	ENST00000314612.2	+	1	358	c.358C>T	c.(358-360)Cgc>Tgc	p.R120C		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						GGCCTATGACCGCTATGTGGC	0.403000													40	57					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52719042	52719042	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr19:52719042C>T	ENST00000322088.6	+	7	876	c.818C>T	c.(817-819)gCa>gTa	p.A273V	PPP2R1A_ENST00000462990.1_Missense_Mutation_p.A94V|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.A218V	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	273	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CTCCAGAAAGCAGTGGGGCCT	0.577000			Mis		clear cell ovarian carcinoma								29	43					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000404276.1_Silent_p.S372S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	61					0	0	1	0	0
HIP1R	9026	broad.mit.edu	37	12	123343408	123343408	+	Missense_Mutation	SNP	C	C	G			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr12:123343408C>G	ENST00000253083.4	+	21	2199	c.2074C>G	c.(2074-2076)Ctg>Gtg	p.L692V		NM_003959.1	NP_003950.1	O75146	HIP1R_HUMAN	huntingtin interacting protein 1 related	692					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			breast(1)|endometrium(5)|kidney(6)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	26	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		GGTGGCAGCTCTGACCCGCTT	0.672000													9	78					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													4	95					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098863	11098863	+	RNA	SNP	A	A	G	rs75318310	by1000genomes	TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr21:11098863A>G	ENST00000470054.1	-	0	62									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccagcctccaactcccccttc	0.627000													5	36					0	0	1	0	0
WDR65	149465	broad.mit.edu	37	1	43663300	43663300	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr1:43663300G>A	ENST00000372492.4	+	7	1523	c.1199G>A	c.(1198-1200)cGc>cAc	p.R400H	WDR65_ENST00000528956.1_Missense_Mutation_p.R400H	NM_001195831.2	NP_001182760.2	Q96MR6	WDR65_HUMAN	WD repeat domain 65	400								p.R400H(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACCTGCATCCGCAAACCCCTT	0.458000													4	136					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	64					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56321703	56321703	+	Splice_Site	SNP	G	G	T			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr19:56321703G>T	ENST00000443188.1	-	5	983	c.271_splice	c.e5-1	p.R91_splice	NLRP11_ENST00000592953.1_5'UTR|NLRP11_ENST00000360133.3_Splice_Site_p.R91_splice|NLRP11_ENST00000589093.1_Splice_Site_p.R91_splice|NLRP11_ENST00000589824.2_Splice_Site_p.R91_splice	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	91	DAPIN.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CCTCCTGATTGCCTAATCCAG	0.343000													22	21					3.62473e-10	3.93542e-10	1	1	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661208	22661208	+	RNA	SNP	C	C	T			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr22:22661208C>T	ENST00000426066.1	+	0	300					NR_027293.1																						CTGAATCATGCAGAATTTGAA	0.408000													9	67					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N|FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													11	113					0	0	1	0	0
IGLV2-33	0	broad.mit.edu	37	22	22930899	22930899	+	RNA	SNP	G	G	A			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr22:22930899G>A	ENST00000390302.2	+	0	152																											TGTGTCCGGGGCTCCTGGACA	0.562000													123	164					0	0	1	0	0
FSCN1	6624	broad.mit.edu	37	7	5632695	5632695	+	Missense_Mutation	SNP	A	A	G			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr7:5632695A>G	ENST00000382361.3	+	1	242	c.128A>G	c.(127-129)aAg>aGg	p.K43R	FSCN1_ENST00000340250.6_Splice_Site_p.N43_splice	NM_003088.3	NP_003079.1	Q16658	FSCN1_HUMAN	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	43					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		CTGAAGAAGAAGCAGATCTGG	0.672000													4	11					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				28	39					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	16					1	1	1	1	0
ADAMTS7	11173	broad.mit.edu	37	15	79051886	79051886	+	Silent	SNP	G	G	A			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr15:79051886G>A	ENST00000388820.4	-	24	5148	c.4938C>T	c.(4936-4938)tgC>tgT	p.C1646C		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1646	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.C1646C(4)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GCAGCGTCTCGCAGAACCCGA	0.701000													5	24					0	0	1	0	0
CTD-2049J23.2	0	broad.mit.edu	37	3	159820697	159820698	+	RNA	INS	-	-	A	rs145340132	by1000genomes	TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr3:159820697_159820698insA	ENST00000497452.1	-	0	517																											TTGGAacagtgaaaaaaaaaag	0.277													6	6	---	---	---	---					
MAML3	55534	broad.mit.edu	37	4	140811064	140811069	+	In_Frame_Del	DEL	TGCTGC	TGCTGC	-	rs71855026		TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr4:140811064_140811069delTGCTGC	ENST00000509479.2	-	2	2377_2382	c.1521_1526delGCAGCA	c.(1519-1527)caa>ca	p.QQQ507del	MAML3_ENST00000327122.5_In_Frame_Del_p.QQQ351del|MAML3_ENST00000398940.1_Splice_Site_p.37_splice	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	506	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					TGAGtgctgttgctgctgctgctgct	0.515													14	127	---	---	---	---					
TRDN	10345	broad.mit.edu	37	6	123786033	123786033	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr6:123786033delA	ENST00000546248.1	-	9	1022	c.889delT	c.(889-891)ctfs	p.S297fs	TRDN_ENST00000334268.4_Intron|RP11-532N4.2_ENST00000418467.2_RNA|RP11-532N4.2_ENST00000427828.1_RNA|RP11-532N4.2_ENST00000589182.1_RNA|TRDN_ENST00000398178.3_Intron|RP11-532N4.2_ENST00000587106.1_RNA|RP11-532N4.2_ENST00000434768.1_RNA	NM_001256020.1	NP_001242949.1	Q13061	TRDN_HUMAN	triadin	0					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		GATCTTTAAGAAAAAAAAAAG	0.388													3	4	---	---	---	---					
SEPT7P2	0	broad.mit.edu	37	7	45776357	45776357	+	RNA	DEL	T	T	-			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr7:45776357delT	ENST00000429741.1	-	0	1217																											AAAGAATACCTTTTTTTGGAG	0.323													2	4	---	---	---	---					
INTS4L2	0	broad.mit.edu	37	7	65150816	65150817	+	RNA	INS	-	-	C			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr7:65150816_65150817insC	ENST00000430126.2	+	0	757																											TTCATCCCTCACCCCCCCCCCC	0.465													3	4	---	---	---	---					
CIZ1	25792	broad.mit.edu	37	9	130953109	130953111	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr9:130953109_130953111delGCT	ENST00000538431.1	-	2	273_275	c.26_28delAGC	c.(25-30)ctc>c	p.QL9del	CIZ1_ENST00000393608.1_In_Frame_Del_p.QL9del|CIZ1_ENST00000372938.5_In_Frame_Del_p.QL9del|CIZ1_ENST00000277465.4_In_Frame_Del_p.QL9del|CIZ1_ENST00000476727.2_5'UTR|CIZ1_ENST00000372948.3_In_Frame_Del_p.QL9del|CIZ1_ENST00000357558.5_In_Frame_Del_p.QL9del|CIZ1_ENST00000325721.8_In_Frame_Del_p.QL9del|CIZ1_ENST00000372954.1_In_Frame_Del_p.QL9del|CIZ1_ENST00000541172.1_5'UTR	NM_001257975.1	NP_001244904.1	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1	9	Gln-rich.			Missing (in Ref. 7; AAF23231).		nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						tgttgctggagctgctgctgctg	0.611													2	4	---	---	---	---					
MBL1P	0	broad.mit.edu	37	10	81680656	81680656	+	RNA	DEL	A	A	-			TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr10:81680656delA	ENST00000480805.1	+	0	723					NR_002724.2																						GCTTTTGGGGAAAAAAAAAAG	0.542													3	5	---	---	---	---					
MUC6	4588	broad.mit.edu	37	11	1017661	1017663	+	In_Frame_Del	DEL	TGT	TGT	-	rs72022620		TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr11:1017661_1017663delTGT	ENST00000421673.2	-	31	5188_5190	c.5138_5140delACA	c.(5137-5142)atc>a	p.NI1713del		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1713	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTGGGGGTGATGTTGGTGGTAGA	0.527													12	1159	---	---	---	---					
RP11-597A11.6	0	broad.mit.edu	37	14	20146543	20146544	+	RNA	INS	-	-	GTCCC	rs60511353		TCGA-DE-A4MA-01A-11D-A257-08	TCGA-DE-A4MA-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a49cc232-3f8a-48fd-b75a-5956c7adc2e8	b9997f86-3401-481d-bd98-a3336618aa57	g.chr14:20146543_20146544insGTCCC	ENST00000555580.1	-	0	225																											CCAACTCAGCAGAACAGTGTCA	0.505													3	5	---	---	---	---					
