Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC39A12	221074	broad.mit.edu	37	10	18242228	18242228	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr10:18242228C>T	ENST00000377369.2	+	2	296	c.23C>T	c.(22-24)tCa>tTa	p.S8L	SLC39A12_ENST00000539911.1_Intron|SLC39A12_ENST00000377374.4_Missense_Mutation_p.S8L|SLC39A12_ENST00000377371.3_Missense_Mutation_p.S8L	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	8					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						ACAAAGCTCTCAGTATCCTGG	0.502000													6	71					0	0	1	0	0
TIMP4	7079	broad.mit.edu	37	3	12198945	12198945	+	Silent	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr3:12198945C>T	ENST00000287814.4	-	2	687	c.177G>A	c.(175-177)ccG>ccA	p.P59P	SYN2_ENST00000432424.2_RNA	NM_003256.3	NP_003247.1	Q99727	TIMP4_HUMAN	TIMP metallopeptidase inhibitor 4	59	NTR.						metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11						CTGCACTGGCCGGAACTACCT	0.522000													3	30					0	0	1	0	0
SPOCK2	9806	broad.mit.edu	37	10	73827958	73827958	+	Silent	SNP	G	G	A			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr10:73827958G>A	ENST00000373109.2	-	6	1020	c.576C>T	c.(574-576)gcC>gcT	p.A192A	SPOCK2_ENST00000460053.1_5'UTR|SPOCK2_ENST00000317376.4_Silent_p.A192A|SPOCK2_ENST00000536168.1_Silent_p.A192A	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	192					extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						GTTTGCCATCGGCGGTGGAGG	0.667000													9	5					0	0	1	0	0
PRLHR	2834	broad.mit.edu	37	10	120353932	120353932	+	Silent	SNP	G	G	A			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr10:120353932G>A	ENST00000239032.2	-	2	963	c.825C>T	c.(823-825)cgC>cgT	p.R275R	PRLHR_ENST00000369169.1_Silent_p.R275R	NM_004248.2	NP_004239.1	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	275					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity			large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		AGCAGAAGGTGCGCCGGCGCC	0.687000													6	29					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34235622	34235622	+	RNA	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr17:34235622C>T	ENST00000587132.1	-	0	2405																											TAGAGGCCTTCGGTTCCTCCT	0.453000													4	61					0	0	1	0	0
TUBBP5	0	broad.mit.edu	37	9	141070768	141070768	+	RNA	SNP	C	C	T	rs4609262	by1000genomes	TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr9:141070768C>T	ENST00000503395.1	+	0	1543																											GCTGTGACTGCCTGCAGGGTT	0.617000													3	23					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664115	22664115	+	RNA	SNP	A	A	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr22:22664115A>T	ENST00000426066.1	+	0	638					NR_027293.1																						TGTTTAATTCAGCCTTGGAAG	0.413000													4	72					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766084	27766084	+	Missense_Mutation	SNP	G	G	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chrX:27766084G>T	ENST00000451261.2	+	5	1471	c.1072G>T	c.(1072-1074)Gtg>Ttg	p.V358L		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						TTCAAAAGTTGTGGTAACAAG	0.448000													5	28					0.000602214	0.000602214	1	1	0
FBXO9	26268	broad.mit.edu	37	6	52945836	52945836	+	Missense_Mutation	SNP	C	C	G			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr6:52945836C>G	ENST00000244426.6	+	5	680	c.508C>G	c.(508-510)Cag>Gag	p.Q170E	FBXO9_ENST00000370939.3_Missense_Mutation_p.Q126E|FBXO9_ENST00000323557.7_Missense_Mutation_p.Q160E	NM_012347.4	NP_036479.1	Q9UK97	FBX9_HUMAN	F-box protein 9	170						ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)|large_intestine(4)|lung(1)|pancreas(2)|skin(1)	9	Lung NSC(77;0.103)					ACTCACATTTCAGGAGTCTGT	0.393000													10	56					0	0	1	0	0
GOLIM4	27333	broad.mit.edu	37	3	167728142	167728142	+	Missense_Mutation	SNP	C	C	A			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr3:167728142C>A	ENST00000470487.1	-	16	2695	c.2006G>T	c.(2005-2007)cGa>cTa	p.R669L	GOLIM4_ENST00000309027.4_Missense_Mutation_p.R641L	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	669	Glu-rich.				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GTGTTCCTCTCGGCCTTTGGG	0.423000													5	83					0.000157383	0.000160805	1	1	0
DDX4	54514	broad.mit.edu	37	5	55082457	55082457	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr5:55082457C>T	ENST00000505374.1	+	14	1068	c.976C>T	c.(976-978)Cga>Tga	p.R326*	DDX4_ENST00000511853.1_Nonsense_Mutation_p.R177*|DDX4_ENST00000354991.5_Nonsense_Mutation_p.R292*|DDX4_ENST00000514278.2_Nonsense_Mutation_p.R306*|DDX4_ENST00000353507.5_Nonsense_Mutation_p.R292*	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	326	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				ACTTGCAGGACGAGATTTGAT	0.413000													4	83					0	0	1	0	0
RBL1	5933	broad.mit.edu	37	20	35651085	35651085	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr20:35651085G>A	ENST00000373664.3	-	17	2593	c.2527C>T	c.(2527-2529)Ctc>Ttc	p.L843F	RBL1_ENST00000344359.3_Missense_Mutation_p.L843F	NM_002895.2	NP_002886.2	P28749	RBL1_HUMAN	retinoblastoma-like 1 (p107)	843	Domain B.|Pocket; binds T and E1A.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				CAAAGGAGGAGCTGATCCAAA	0.418000													6	71					0	0	1	0	0
SLC2A1	6513	broad.mit.edu	37	1	43395605	43395605	+	Silent	SNP	G	G	A			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr1:43395605G>A	ENST00000426263.3	-	5	796	c.618C>T	c.(616-618)ttC>ttT	p.F206F	SLC2A1_ENST00000475162.1_Intron|SLC2A1_ENST00000415851.2_Intron	NM_006516.2	NP_006507.2	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 1	206					carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|pancreas(2)	13	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	TCTCGGGGCAGAAGGGCAGCA	0.642000													5	86					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51250835	51250835	+	Silent	SNP	G	G	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr15:51250835G>T	ENST00000261842.5	+	14	1801	c.1695G>T	c.(1693-1695)gcG>gcT	p.A565A	AP4E1_ENST00000560508.1_Silent_p.A490A	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	565					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		CATCTCAGGCGCACTCTTCTA	0.353000													17	42					3.45872e-05	3.61244e-05	1	1	0
MIA3	375056	broad.mit.edu	37	1	222803243	222803243	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr1:222803243C>T	ENST00000344922.5	+	4	2706	c.2681C>T	c.(2680-2682)tCt>tTt	p.S894F	MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344441.6_Missense_Mutation_p.S894F|MIA3_ENST00000344507.1_Intron	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	894					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		AGCCAGGGGTCTGCTGCTGCA	0.517000													4	77					0	0	1	0	0
FAM86B2	653333	broad.mit.edu	37	8	12286307	12286307	+	Missense_Mutation	SNP	T	T	C	rs148161726		TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr8:12286307T>C	ENST00000262365.4	-	6	576	c.577A>G	c.(577-579)Atc>Gtc	p.I193V	FAM86B2_ENST00000351291.4_Missense_Mutation_p.I159V|FAM86B2_ENST00000393715.3_Intron|FAM86B2_ENST00000309608.5_Intron	NM_001137610.1	NP_001131082.1	P0C5J1	F86B2_HUMAN	family with sequence similarity 86, member B2	193										endometrium(1)|kidney(2)	3						TGCTCGAGGATCCGGCTGTGA	0.602000													3	32					0	0	1	0	0
ZBTB8OS	339487	broad.mit.edu	37	1	33099302	33099302	+	Missense_Mutation	SNP	G	G	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr1:33099302G>T	ENST00000468695.1	-	4	325	c.307C>A	c.(307-309)Cac>Aac	p.H103N	ZBTB8OS_ENST00000373501.2_Missense_Mutation_p.H91N|ZBTB8OS_ENST00000492007.1_Intron|ZBTB8OS_ENST00000341885.5_Intron	NM_178547.2	NP_848642.1	Q8IWT0	ARCH_HUMAN	zinc finger and BTB domain containing 8 opposite strand	91										endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TCCAAAAAGTGAAACAGAAGA	0.318000													5	43					1.23904e-05	1.32352e-05	1	1	0
AKT1	207	broad.mit.edu	37	14	105246445	105246445	+	Missense_Mutation	SNP	A	A	C			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr14:105246445A>C	ENST00000554581.1	-	2	1635	c.155T>G	c.(154-156)cTc>cGc	p.L52R	AKT1_ENST00000555528.1_Missense_Mutation_p.L52R|AKT1_ENST00000554848.1_Missense_Mutation_p.L52R|AKT1_ENST00000407796.2_Missense_Mutation_p.L52R|AKT1_ENST00000402615.2_Missense_Mutation_p.L52R|AKT1_ENST00000349310.3_Missense_Mutation_p.L52R			P31749	AKT1_HUMAN	v-akt murine thymoma viral oncogene homolog 1	52	PH.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity	p.L52R(2)		NS(3)|breast(97)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(7)|lung(10)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|thyroid(10)|urinary_tract(15)	176		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	GAAGTTGTTGAGGGGAGCCTC	0.592000		1	Mis		"""breast, colorectal, ovarian, NSCLC"""								12	28					0	0	1	0	0
FGF13	2258	broad.mit.edu	37	X	137717796	137717796	+	Silent	SNP	G	G	A			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chrX:137717796G>A	ENST00000315930.6	-	4	1084	c.423C>T	c.(421-423)tgC>tgT	p.C141C	FGF13_ENST00000370603.3_Silent_p.C151C|FGF13_ENST00000541469.1_Silent_p.C95C|FGF13_ENST00000441825.2_Silent_p.C122C|FGF13_ENST00000305414.4_Silent_p.C88C	NM_004114.3	NP_004105.1	Q92913	FGF13_HUMAN	fibroblast growth factor 13	141					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	24	Acute lymphoblastic leukemia(192;0.000127)					CTTTGAATTTGCACTCAGGTG	0.368000													12	35					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77247129	77247129	+	Missense_Mutation	SNP	T	T	C			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr4:77247129T>C	ENST00000388914.3	-	22	3190	c.3038A>G	c.(3037-3039)aAt>aGt	p.N1013S		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	1013	Ser-rich.									breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						AGGAGAAGAATTGAATGAACG	0.368000													50	95					0	0	1	0	0
ZNF724P	0	broad.mit.edu	37	19	23405665	23405665	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr19:23405665C>T	ENST00000418100.1	-	4	1499	c.1382G>A	c.(1381-1383)cGg>cAg	p.R461Q																	endometrium(3)|kidney(1)|lung(2)|ovary(2)	8						GTTTGAGGACCGCTTAAAAGC	0.383000													27	46					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11304503	11304503	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr19:11304503C>T	ENST00000432929.2	-	4	613	c.253G>A	c.(253-255)Gag>Aag	p.E85K	KANK2_ENST00000355150.5_Missense_Mutation_p.E85K|KANK2_ENST00000586659.1_Missense_Mutation_p.E85K|KANK2_ENST00000589894.1_Missense_Mutation_p.E85K|KANK2_ENST00000589359.1_Missense_Mutation_p.E85K	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	85										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						CACAGCGACTCAGTGGACGTC	0.677000													6	86					0	0	1	0	0
MIB2	142678	broad.mit.edu	37	1	1560433	1560433	+	Missense_Mutation	SNP	A	A	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr1:1560433A>T	ENST00000357210.4	+	6	979	c.763A>T	c.(763-765)Agt>Tgt	p.S255C	MIB2_ENST00000378712.1_Intron|MIB2_ENST00000520777.1_Missense_Mutation_p.S312C|MIB2_ENST00000360522.4_Missense_Mutation_p.S255C|MIB2_ENST00000378710.3_Missense_Mutation_p.S255C|MIB2_ENST00000355826.5_Missense_Mutation_p.S298C|MIB2_ENST00000378708.1_Missense_Mutation_p.S197C|MIB2_ENST00000518681.1_Intron|MIB2_ENST00000505820.2_Missense_Mutation_p.S312C|MIB2_ENST00000504599.1_Missense_Mutation_p.S211C	NM_080875.2	NP_543151.2	Q96AX9	MIB2_HUMAN	mindbomb E3 ubiquitin protein ligase 2	255	MIB/HERC2 2.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|lung(7)|prostate(4)|upper_aerodigestive_tract(1)	18	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GACAGGCCGGAGTGTGGCCAG	0.662000													32	47					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58547113	58547113	+	Missense_Mutation	SNP	G	G	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr20:58547113G>T	ENST00000348616.4	+	4	628	c.328G>T	c.(328-330)Gat>Tat	p.D110Y	CDH26_ENST00000244047.5_Missense_Mutation_p.D110Y	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	110	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TTCTCTAGAAGATCATGAGAA	0.383000													9	38					1.12685e-05	1.23167e-05	1	1	0
CRYL1	51084	broad.mit.edu	37	13	21006266	21006266	+	Missense_Mutation	SNP	A	A	G			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr13:21006266A>G	ENST00000382812.1	-	6	770	c.542T>C	c.(541-543)aTc>aCc	p.I181T	CRYL1_ENST00000298248.7_Missense_Mutation_p.I203T|CRYL1_ENST00000480748.1_5'UTR			Q9Y2S2	CRYL1_HUMAN	crystallin, lambda 1	203					fatty acid metabolic process	cytosol	3-hydroxyacyl-CoA dehydrogenase activity|L-gulonate 3-dehydrogenase activity|NAD+ binding|protein homodimerization activity			NS(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(29;2.27e-23)|all_epithelial(30;1.69e-19)|all_lung(29;8.29e-18)|Lung SC(185;0.0262)|Ovarian(182;0.0827)|Hepatocellular(188;0.244)		all cancers(112;6.6e-05)|Epithelial(112;0.00178)|OV - Ovarian serous cystadenocarcinoma(117;0.0169)|Lung(94;0.0215)|GBM - Glioblastoma multiforme(144;0.0402)|LUSC - Lung squamous cell carcinoma(192;0.061)		GGCCTCGCTGATGATTGCATA	0.587000													20	32					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171083277	171083277	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr1:171083277G>T	ENST00000367755.4	+	7	1069	c.958G>T	c.(958-960)Gag>Tag	p.E320*	FMO3_ENST00000392085.2_Nonsense_Mutation_p.E320*|FMO3_ENST00000542847.1_Nonsense_Mutation_p.E300*|FMO3_ENST00000538429.1_Nonsense_Mutation_p.E257*	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	320					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GACCATATTTGAGGGCATTGA	0.433000													41	67					9.84934e-19	1.10219e-18	1	1	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													4	69					0	0	1	0	0
CPSF1	29894	broad.mit.edu	37	8	145624726	145624726	+	Silent	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr8:145624726C>T	ENST00000349769.3	-	14	1426	c.1332G>A	c.(1330-1332)gaG>gaA	p.E444E		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	444					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			ACACTTCAATCTCGTCCACCT	0.662000													8	22					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43484051	43484051	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr18:43484051C>T	ENST00000282041.5	-	25	4395	c.4361G>A	c.(4360-4362)cGc>cAc	p.R1454H	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	1454					autophagy			p.R1454H(1)		NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						ATGATAGATGCGCTCCATGTT	0.443000													27	57					0	0	1	0	0
PKM	5315	broad.mit.edu	37	15	72494909	72494909	+	Missense_Mutation	SNP	A	A	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr15:72494909A>T	ENST00000335181.5	-	9	1296	c.1193T>A	c.(1192-1194)cTc>cAc	p.L398H	PKM_ENST00000389093.3_Intron|PKM_ENST00000565184.1_Intron|PKM_ENST00000449901.2_Missense_Mutation_p.L383H|PKM_ENST00000568883.1_Intron|PKM_ENST00000568459.1_Intron|PKM_ENST00000565154.1_Intron|PKM_ENST00000319622.6_Intron	NM_002654.4	NP_002645.3			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						CAGGCGGCGGAGTTCCTCAAA	0.612000													4	20					0	0	1	0	0
PIPSL	0	broad.mit.edu	37	10	95721200	95721200	+	RNA	SNP	G	G	A			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr10:95721200G>A	ENST00000480546.1	-	0	97					NR_002319.2																						GGAAGGGACCGCGGGATCAAC	0.582000													8	106					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	744525	744525	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr9:744525C>T	ENST00000382303.1	+	15	4584	c.3932C>T	c.(3931-3933)gCa>gTa	p.A1311V	KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382293.3_Missense_Mutation_p.A1153V|KANK1_ENST00000382297.2_Missense_Mutation_p.A1311V	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	1311					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GCCCTGGAAGCAGGACACAAG	0.478000													4	88					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984086	41984086	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr4:41984086G>A	ENST00000333141.5	+	1	374	c.277G>A	c.(277-279)Gaa>Aaa	p.E93K		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	93										breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						GAACCAGGTCGAAGTCGAAGG	0.537000													19	50					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				26	43					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34076666	34076666	+	Silent	SNP	C	C	G			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr1:34076666C>G	ENST00000373381.4	-	41	6494	c.6318G>C	c.(6316-6318)cgG>cgC	p.R2106R	CSMD2_ENST00000373380.1_Silent_p.R979R|CSMD2_ENST00000373377.1_Silent_p.R205R|CSMD2_ENST00000373388.2_Silent_p.R205R	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2066						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGAATCCTGGCCGATTCTGGG	0.567000													7	29					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028585	37028585	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chrX:37028585G>A	ENST00000358047.3	+	1	2154	c.2102G>A	c.(2101-2103)cGt>cAt	p.R701H		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	701										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGTGTCCCGTCTCCACCCA	0.647000													4	135					0	0	1	0	0
IQUB	154865	broad.mit.edu	37	7	123152231	123152231	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr7:123152231C>T	ENST00000466202.1	-	2	740	c.164G>A	c.(163-165)aGc>aAc	p.S55N	IQUB_ENST00000434450.1_Missense_Mutation_p.S55N|IQUB_ENST00000488987.1_Intron|IQUB_ENST00000324698.6_Missense_Mutation_p.S55N			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	55										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						TATTGCATGGCTCTCACTGAA	0.423000													34	62					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10114761	10114761	+	Missense_Mutation	SNP	G	G	A	rs148469753		TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr19:10114761G>A	ENST00000264828.3	-	5	740	c.655C>T	c.(655-657)Cgg>Tgg	p.R219W		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	219	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGGAGGTACCGCTCACAAGCC	0.602000													21	51					0	0	1	0	0
INTS4L2	0	broad.mit.edu	37	7	65150814	65150815	+	RNA	INS	-	-	C			TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr7:65150814_65150815insC	ENST00000430126.2	+	0	757																											TCTTCATCCCTCACCCCCCCCC	0.460													3	6	---	---	---	---					
MIR3648	0	broad.mit.edu	37	21	9825838	9825839	+	RNA	INS	-	-	GCG	rs3052281		TCGA-DE-A4MB-01A-11D-A257-08	TCGA-DE-A4MB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83ea1409-56e4-4ffb-beb2-9275a70e9bb5	ca920f65-56bb-4a76-935e-ceceb4767793	g.chr21:9825838_9825839insGCG	ENST00000581792.1	+	0	7_8					NR_037421.1																						cggccgcgactgcggcggcggt	0.842													3	5	---	---	---	---					
