Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ATP2A2	488	broad.mit.edu	37	12	110783837	110783837	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr12:110783837C>T	ENST00000395494.2	+	18	3255	c.2692C>T	c.(2692-2694)Ccc>Tcc	p.P898S	ATP2A2_ENST00000539276.2_Missense_Mutation_p.P925S|ATP2A2_ENST00000308664.6_Missense_Mutation_p.P925S			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	925					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						GCTGAGGATGCCCCCCTGGGA	0.577000													4	191					0	0	0.150653	0	0
OCRL	4952	broad.mit.edu	37	X	128709895	128709895	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chrX:128709895T>C	ENST00000371113.4	+	17	1900	c.1735T>C	c.(1735-1737)Ttt>Ctt	p.F579L	OCRL_ENST00000357121.5_Missense_Mutation_p.F579L	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	579					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						AAATGTGAAGTTTCGGCAACT	0.408000													85	129					0	0	0.870114	0	0
EPHB1	2047	broad.mit.edu	37	3	134670486	134670486	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr3:134670486C>T	ENST00000398015.3	+	3	767	c.397C>T	c.(397-399)Ccc>Tcc	p.P133S	EPHB1_ENST00000488154.1_3'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	133						integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						GTCTGAGGCCCCCTACCTCAA	0.507000													72	182					0	0	0.870114	0	0
ATP8B2	57198	broad.mit.edu	37	1	154318750	154318750	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr1:154318750A>G	ENST00000368489.3	+	25	2921	c.2921A>G	c.(2920-2922)gAg>gGg	p.E974G		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	960					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AAGCTGTATGAGCCGGGCCAG	0.572000													3	172					0	0	0.150653	0	0
CLCC1	23155	broad.mit.edu	37	1	109492526	109492526	+	Silent	SNP	T	T	C			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr1:109492526T>C	ENST00000369971.2	-	3	276	c.147A>G	c.(145-147)tcA>tcG	p.S49S	CLCC1_ENST00000369970.3_Silent_p.S49S|CLCC1_ENST00000415331.1_Silent_p.S49S|CLCC1_ENST00000356970.2_Silent_p.S49S|CLCC1_ENST00000369969.2_Silent_p.S49S|CLCC1_ENST00000348264.2_Silent_p.S49S|CLCC1_ENST00000302500.4_Silent_p.S49S|AKNAD1_ENST00000357393.4_Intron|CLCC1_ENST00000369976.1_Silent_p.S49S|CLCC1_ENST00000369968.2_Silent_p.S49S	NM_001048210.1	NP_001041675.1	Q96S66	CLCC1_HUMAN	chloride channel CLIC-like 1	49						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|liver(1)|skin(1)	14		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		CCTTTTCCCCTGAAATACCAT	0.294000													4	89					0	0	0.150653	0	0
SDK2	54549	broad.mit.edu	37	17	71375612	71375612	+	Silent	SNP	C	C	T	rs144878236	byFrequency	TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr17:71375612C>T	ENST00000392650.3	-	35	4839	c.4839G>A	c.(4837-4839)ccG>ccA	p.P1613P	SDK2_ENST00000388726.3_Silent_p.P1594P	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1613	Fibronectin type-III 10.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						AGACCTCCTGCGGGGGGCTGG	0.657000													17	28					0	0	0.575678	0	0
NUDT10	170685	broad.mit.edu	37	X	51076024	51076024	+	Silent	SNP	G	G	A	rs143435240	byFrequency	TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chrX:51076024G>A	ENST00000376006.3	+	2	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_ENST00000356450.2_Silent_p.E69E	NM_153183.2	NP_694853.1	Q8NFP7	NUD10_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 10	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(8)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657000													4	67					0	0	0.150653	0	0
FAM86DP	0	broad.mit.edu	37	3	75475709	75475709	+	RNA	SNP	T	T	C			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr3:75475709T>C	ENST00000459803.1	-	0	820					NR_024241.1													p.I261V(1)									CTCCGCAGGATCCCGACCAGC	0.562000													2	21					0	0	0.115264	0	0
SCYL3	57147	broad.mit.edu	37	1	169857896	169857896	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr1:169857896G>T	ENST00000367772.4	-	2	283	c.86C>A	c.(85-87)gCt>gAt	p.A29D	SCYL3_ENST00000367771.5_Missense_Mutation_p.A29D|SCYL3_ENST00000470238.1_5'UTR|SCYL3_ENST00000367770.1_Missense_Mutation_p.A29D	NM_181093.3	NP_851607.2	Q8IZE3	PACE1_HUMAN	SCY1-like 3 (S. cerevisiae)	29	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTGCAGTACAGCGGGATAAAC	0.418000													4	112					0.000602214	0.000699346	0.184627	1	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296226	39296226	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr17:39296226G>A	ENST00000345847.4	-	1	513	c.514C>T	c.(514-516)Cgt>Tgt	p.R172C		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	168						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						CAGACTGGACGCAGgcagcag	0.657000													5	3					0	0	0.248553	0	0
TNS1	7145	broad.mit.edu	37	2	218696243	218696243	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr2:218696243G>C	ENST00000171887.4	-	20	3385	c.2933C>G	c.(2932-2934)aCa>aGa	p.T978R	TNS1_ENST00000419504.1_Missense_Mutation_p.T978R|TNS1_ENST00000430930.1_Missense_Mutation_p.T978R	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	978						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		AGACAGGGGTGTCTTGGCCAG	0.652000													8	14					0	0	0.335167	0	0
ABI3BP	25890	broad.mit.edu	37	3	100567712	100567712	+	Silent	SNP	C	C	T			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr3:100567712C>T	ENST00000471714.1	-	18	1639	c.1530G>A	c.(1528-1530)caG>caA	p.Q510Q	ABI3BP_ENST00000284322.5_Silent_p.Q461Q|ABI3BP_ENST00000495063.1_Silent_p.Q510Q			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	461	Pro-rich.					extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						ATGTAGTTTGCTGGGGAGCTG	0.398000													3	75					0	0	0.150653	0	0
SDHD	6392	broad.mit.edu	37	11	111959647	111959647	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr11:111959647C>T	ENST00000375549.3	+	3	361	c.226C>T	c.(226-228)Ctc>Ttc	p.L76F	SDHD_ENST00000525291.1_Missense_Mutation_p.L37F|SDHD_ENST00000528048.1_Intron|SDHD_ENST00000528182.1_Missense_Mutation_p.L76F|SDHD_ENST00000528021.1_Missense_Mutation_p.L76F|SDHD_ENST00000526592.1_Missense_Mutation_p.L76F|SDHD_ENST00000532699.1_Missense_Mutation_p.L76F	NM_003002.2	NP_002993.1	O14521	DHSD_HUMAN	succinate dehydrogenase complex, subunit D, integral membrane protein	76					respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II	electron carrier activity|heme binding|succinate dehydrogenase activity|ubiquinone binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	9		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.13e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;1.05e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0515)	Succinic acid(DB00139)	CAGTGTTTTGCTCCTGGGTCT	0.498000			"""Mis, N, F, S"""			"""paraganglioma, pheochromocytoma"""			Familial Paragangliomas;Cowden syndrome;Carney-Stratakis syndrome				5	89					0	0	0.184627	0	0
AC008103.5	0	broad.mit.edu	37	22	18846025	18846025	+	RNA	SNP	G	G	C	rs5993363		TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr22:18846025G>C	ENST00000412938.1	+	0	3383																											GACGTTGAAGGCTGCCTTCAG	0.647000													3	89					0	0	0.150653	0	0
GLCE	26035	broad.mit.edu	37	15	69561376	69561376	+	Silent	SNP	G	G	T			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr15:69561376G>T	ENST00000261858.2	+	5	1875	c.1647G>T	c.(1645-1647)ctG>ctT	p.L549L	GLCE_ENST00000559420.2_Silent_p.L485L	NM_015554.1	NP_056369.1	O94923	GLCE_HUMAN	glucuronic acid epimerase	549					heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	18						AAGCCATGCTGCCCTTGTATG	0.488000													4	188					0.150653	0.164349	0.150653	1	0
OR5L2	26338	broad.mit.edu	37	11	55594762	55594762	+	Nonsense_Mutation	SNP	T	T	A			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr11:55594762T>A	ENST00000378397.1	+	1	68	c.68T>A	c.(67-69)tTg>tAg	p.L23*		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				GTCCCTGAGTTGAGAGTCTGC	0.488000										HNSCC(27;0.073)			7	368					0	0	0.248553	0	0
RAB25	57111	broad.mit.edu	37	1	156038145	156038145	+	Silent	SNP	G	G	A			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr1:156038145G>A	ENST00000361084.5	+	3	565	c.324G>A	c.(322-324)aaG>aaA	p.K108K	RAB25_ENST00000487325.1_3'UTR	NM_020387.2	NP_065120.2	P57735	RAB25_HUMAN	RAB25, member RAS oncogene family	108					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	Hepatocellular(266;0.158)|all_neural(408;0.195)					GATGGCTGAAGGAGCTCTATG	0.582000													5	211					0	0	0.184627	0	0
KLB	152831	broad.mit.edu	37	4	39448955	39448955	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr4:39448955G>A	ENST00000257408.4	+	4	2706	c.2609G>A	c.(2608-2610)cGc>cAc	p.R870H		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	870	Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						TGGGGGGTGCGCAAGCTGCTG	0.657000													4	171					0	0	0.184627	0	0
TPH2	121278	broad.mit.edu	37	12	72388217	72388217	+	Splice_Site	SNP	A	A	G			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr12:72388217A>G	ENST00000333850.3	+	8	1082		c.e8-1			NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2						aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	CTTTTTTGTCAGAGACACATG	0.393000													82	101					0	0	0.870114	0	0
TPST2	8459	broad.mit.edu	37	22	26937461	26937461	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr22:26937461G>A	ENST00000338754.4	-	3	406	c.136C>T	c.(136-138)Cgg>Tgg	p.R46W	TPST2_ENST00000403880.1_Missense_Mutation_p.R46W|TPST2_ENST00000398110.2_Missense_Mutation_p.R46W	NM_003595.3	NP_003586.3	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	46					peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)|large_intestine(1)|lung(5)	7						TGCTCAGGCCGCATGGCCCCC	0.701000													3	51					0	0	0.150653	0	0
CACNA1B	774	broad.mit.edu	37	9	140809138	140809138	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr9:140809138G>A	ENST00000371372.1	+	5	800	c.655G>A	c.(655-657)Gcc>Acc	p.A219T	CACNA1B_ENST00000371363.1_Missense_Mutation_p.A219T|CACNA1B_ENST00000277551.2_Missense_Mutation_p.A219T|CACNA1B_ENST00000371355.4_Missense_Mutation_p.A219T|CACNA1B_ENST00000371357.1_Missense_Mutation_p.A219T|CACNA1B_ENST00000277549.5_5'UTR	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	219					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CATCATGAAGGCCATGGTTCC	0.557000													12	29					0	0	0.387290	0	0
OR2A12	346525	broad.mit.edu	37	7	143793094	143793094	+	Silent	SNP	G	G	A			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr7:143793094G>A	ENST00000408949.2	+	1	954	c.894G>A	c.(892-894)ggG>ggA	p.G298G		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					AGGTGAAAGGGGCTCTAAAGA	0.453000													5	383					0	0	0.184627	0	0
OCRL	4952	broad.mit.edu	37	X	128709875	128709875	+	Splice_Site	SNP	T	T	A			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chrX:128709875T>A	ENST00000371113.4	+	17	1880	c.1713_splice	c.e17-1	p.F572_splice	OCRL_ENST00000357121.5_Splice_Site_p.F572_splice	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	572					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						ATTCCCCAGTTTGTGTTTGAA	0.393000													81	111					0	0	0.870114	0	0
MNF1	0	broad.mit.edu	37	6	33669185	33669185	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr6:33669185C>G	ENST00000607484.1	-	2	191	c.151G>C	c.(151-153)Gag>Cag	p.E51Q	MNF1_ENST00000374214.3_Intron	NM_032340.3	NP_115716.1	Q9BRT2	CF125_HUMAN		51																	TCACAGGCCTCAGGCTCTGCA	0.473000													6	143					0	0	0.217242	0	0
OR2L3	391192	broad.mit.edu	37	1	248224344	248224344	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr1:248224344C>T	ENST00000359959.3	+	1	361	c.361C>T	c.(361-363)Cgt>Tgt	p.R121C	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GGCCTATGATCGTTACATTGC	0.443000													136	182					0	0	0.870114	0	0
KANK2	25959	broad.mit.edu	37	19	11287390	11287390	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr19:11287390C>T	ENST00000432929.2	-	7	2008	c.1648G>A	c.(1648-1650)Gcc>Acc	p.A550T	KANK2_ENST00000355150.5_Missense_Mutation_p.A542T|KANK2_ENST00000586659.1_Missense_Mutation_p.A542T|KANK2_ENST00000589359.1_Missense_Mutation_p.A550T|KANK2_ENST00000589894.1_Missense_Mutation_p.A542T	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	542										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GGGGCTTCGGCCACACTCGGA	0.622000													27	112					0	0	0.681144	0	0
SEC62	7095	broad.mit.edu	37	3	169700673	169700673	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr3:169700673G>A	ENST00000337002.4	+	4	488	c.430G>A	c.(430-432)Gat>Aat	p.D144N	SEC62_ENST00000480708.1_Missense_Mutation_p.D144N|SEC62-AS1_ENST00000479626.1_RNA	NM_003262.3	NP_003253.1	Q99442	SEC62_HUMAN	SEC62 homolog (S. cerevisiae)	144					cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	9						gaaaaaaaaagatggtgaaaa	0.289000													3	48					0	0	0.115264	0	0
NAV3	89795	broad.mit.edu	37	12	78515989	78515989	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr12:78515989C>T	ENST00000397909.2	+	16	4192	c.4019C>T	c.(4018-4020)aCa>aTa	p.T1340I	NAV3_ENST00000536525.2_Missense_Mutation_p.T1340I|NAV3_ENST00000266692.7_Intron|NAV3_ENST00000228327.6_Missense_Mutation_p.T1340I			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1340	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CACTCTTTCACATCAGGTGGT	0.517000										HNSCC(70;0.22)			13	165					0	0	0.435327	0	0
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	GACGGG	-	rs112040677		TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr2:131129929_131129934delGACGGG	ENST00000175756.5	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)cag>ca	p.QTG371del	PTPN18_ENST00000347849.3_In_Frame_Del_p.QTG264del	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	371						cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity	p.T378_G379delTG(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.777													2	4	---	---	---	---					
AC073321.4	0	broad.mit.edu	37	2	217475031	217475032	+	RNA	INS	-	-	AA	rs71401156		TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr2:217475031_217475032insAA	ENST00000441803.1	+	0	195																											AATTTTATTTCAAAAAAAAAAA	0.376													3	4	---	---	---	---					
GRIP2	80852	broad.mit.edu	37	3	14555758	14555759	+	RNA	INS	-	-	AGTT	rs10656368	by1000genomes	TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr3:14555758_14555759insAGTT	ENST00000273083.3	-	0	1558							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CAGTTTCTCTCAGAGAGTGGCA	0.579													2	4	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102737277	102737283	+	RNA	DEL	TTTCCAT	TTTCCAT	-	rs28381683		TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr11:102737277_102737283delTTTCCAT	ENST00000532855.1	-	0	1007							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	CCAATATTTCTTTCCATTGTCTTCACA	0.362													4	6	---	---	---	---					
LINC00639	0	broad.mit.edu	37	14	39304293	39304296	+	RNA	DEL	CACA	CACA	-	rs5808014	by1000genomes	TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr14:39304293_39304296delCACA	ENST00000553932.1	-	0	3985																											CGCCCTGCTCcacacacacacaca	0.475													3	3	---	---	---	---					
RP11-1166P10.6	0	broad.mit.edu	37	16	32095553	32095553	+	RNA	DEL	G	G	-			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr16:32095553delG	ENST00000566806.1	-	0	499																											CTGGGGCCCCGAGGGAGATGT	0.642													2	4	---	---	---	---					
RP5-991G20.1	0	broad.mit.edu	37	16	72763868	72763869	+	RNA	INS	-	-	A			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr16:72763868_72763869insA	ENST00000563328.2	+	0	164																											CGGTCCAAAACAAAAAAAAAAA	0.436													6	5	---	---	---	---					
JUNB	3726	broad.mit.edu	37	19	12903374	12903374	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr19:12903374delG	ENST00000302754.4	+	1	1065	c.789delG	c.(787-789)atfs	p.M263fs		NM_002229.2	NP_002220.1	P17275	JUNB_HUMAN	jun B proto-oncogene	263						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|kidney(1)|lung(3)	6						CCATCAACATGGAAGACCAAG	0.706													2	4	---	---	---	---					
TPTEP1	0	broad.mit.edu	37	22	17131430	17131432	+	RNA	DEL	CAC	CAC	-	rs142037179		TCGA-DJ-A13W-01A-11D-A10S-08	TCGA-DJ-A13W-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c18a8b7-bad1-4aa4-a6df-472f89d9761c	af0cf9aa-5510-4af9-9bb4-a7e25e446245	g.chr22:17131430_17131432delCAC	ENST00000426585.1	+	0	2456_2458																											caccatccatcaccaacagaaac	0.443													2	4	---	---	---	---					
