Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FGGY	55277	broad.mit.edu	37	1	59922666	59922666	+	Silent	SNP	T	T	C			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr1:59922666T>C	ENST00000371218.4	+	6	772	c.588T>C	c.(586-588)taT>taC	p.Y196Y	FGGY_ENST00000303721.7_Silent_p.Y196Y|FGGY_ENST00000371212.1_Silent_p.Y108Y|FGGY_ENST00000474476.1_3'UTR	NM_001113411.1	NP_001106882.1	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	196					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(7;7.36e-05)					AGTGGACATATTCAGCAGAGA	0.373000													8	62					0	0	1	0	0
ARSJ	79642	broad.mit.edu	37	4	114824011	114824011	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr4:114824011T>C	ENST00000315366.7	-	2	2085	c.1219A>G	c.(1219-1221)Ata>Gta	p.I407V	ARSJ_ENST00000541197.1_Missense_Mutation_p.I407V	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	407						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		CCCTCACTTATGGTCTCCCAG	0.473000													9	131					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29989600	29989600	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr16:29989600C>T	ENST00000308893.4	+	4	1275	c.232C>T	c.(232-234)Cgg>Tgg	p.R78W	TAOK2_ENST00000543033.1_Missense_Mutation_p.R78W|TAOK2_ENST00000279394.3_Missense_Mutation_p.R78W	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	78	Protein kinase.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CAAGGAGGTGCGGTTCTTACA	0.577000													5	302					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175328868	175328868	+	Splice_Site	SNP	C	C	T			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr1:175328868C>T	ENST00000367674.1	-	15	3563		c.e15-1		TNR_ENST00000263525.2_Splice_Site	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R						axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TTGTCCATGGCTGAAACAGAA	0.483000													17	32					0	0	1	0	0
SOS2	6655	broad.mit.edu	37	14	50626379	50626379	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr14:50626379G>A	ENST00000216373.5	-	10	1896	c.1622C>T	c.(1621-1623)tCt>tTt	p.S541F	SOS2_ENST00000543680.1_Missense_Mutation_p.S508F|SOS2_ENST00000555794.1_5'UTR	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	541	PH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity	p.S541Y(2)		cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					ATAATGAAGAGAAATAAGGGC	0.358000													37	57					0	0	1	0	0
EBAG9	9166	broad.mit.edu	37	8	110567042	110567042	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr8:110567042C>G	ENST00000337573.5	+	4	547	c.247C>G	c.(247-249)Caa>Gaa	p.Q83E	EBAG9_ENST00000531677.1_Missense_Mutation_p.Q83E|EBAG9_ENST00000395785.2_Missense_Mutation_p.Q83E|EBAG9_ENST00000529502.1_3'UTR	NM_004215.3	NP_004206.1	O00559	RCAS1_HUMAN	estrogen receptor binding site associated, antigen, 9	83					apoptosis|regulation of cell growth	focal adhesion|Golgi membrane|integral to membrane|soluble fraction	apoptotic protease activator activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)	10			OV - Ovarian serous cystadenocarcinoma(57;1.39e-14)			TGTGGCAACACAACAAAATTC	0.388000													8	83					0	0	1	0	0
EPHX2	2053	broad.mit.edu	37	8	27361137	27361137	+	Missense_Mutation	SNP	A	A	T			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr8:27361137A>T	ENST00000521400.1	+	3	633	c.203A>T	c.(202-204)gAa>gTa	p.E68V	EPHX2_ENST00000520666.1_3'UTR|EPHX2_ENST00000521780.1_Missense_Mutation_p.E2V|EPHX2_ENST00000518379.1_Missense_Mutation_p.E68V|EPHX2_ENST00000517536.1_Intron|EPHX2_ENST00000380476.3_Missense_Mutation_p.E15V	NM_001979.5	NP_001970.2	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	68	Phosphatase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	27		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	CCACTCATGGAAGAAAACTGC	0.438000													3	15					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461589	11461589	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr12:11461589A>G	ENST00000279575.1	-	3	361	c.328T>C	c.(328-330)Tcc>Ccc	p.S110P	PRB4_ENST00000535904.1_Missense_Mutation_p.S110P|PRB4_ENST00000445719.2_Missense_Mutation_p.S110P	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	152	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.					extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						GTACCTTGGGACTGGTTTCCT	0.602000										HNSCC(22;0.051)			9	446					0	0	1	0	0
AC006293.3	0	broad.mit.edu	37	19	55221570	55221570	+	RNA	SNP	A	A	C			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr19:55221570A>C	ENST00000413439.1	+	0	1350																											TACAGATGCTACGGTGCACAC	0.677000													5	73					0	0	1	0	0
YPEL3	83719	broad.mit.edu	37	16	30106212	30106212	+	Silent	SNP	G	G	A			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr16:30106212G>A	ENST00000562641.1	-	3	811	c.282C>T	c.(280-282)aaC>aaT	p.N94N	YPEL3_ENST00000566595.1_Silent_p.N56N|YPEL3_ENST00000565479.1_5'UTR|YPEL3_ENST00000398841.1_Silent_p.N94N|YPEL3_ENST00000566134.1_Intron|YPEL3_ENST00000563788.1_Silent_p.N56N|YPEL3_ENST00000398838.4_Silent_p.N56N			P61236	YPEL3_HUMAN	yippee-like 3 (Drosophila)	56						nucleolus		p.N94N(1)		endometrium(1)|lung(2)	3						CGCAGCCCACGTTCACCCTGT	0.622000													35	46					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78594266	78594266	+	Silent	SNP	C	C	T			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr12:78594266C>T	ENST00000397909.2	+	38	6902	c.6729C>T	c.(6727-6729)ttC>ttT	p.F2243F	NAV3_ENST00000266692.7_Silent_p.F2044F|NAV3_ENST00000536525.2_Silent_p.F2221F|NAV3_ENST00000541270.1_Silent_p.F73F|NAV3_ENST00000228327.6_Silent_p.F2221F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2243						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CCCGACTATTCCTTCCTTGCC	0.343000										HNSCC(70;0.22)			29	30					0	0	1	0	0
ZIC2	7546	broad.mit.edu	37	13	100635025	100635025	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr13:100635025A>G	ENST00000376335.3	+	1	1000	c.707A>G	c.(706-708)cAc>cGc	p.H236R		NM_007129.3	NP_009060.2	O95409	ZIC2_HUMAN	Zic family member 2	236	Necessary for interaction with MDFIC and transcriptional activation or repression (By similarity).|Poly-His.				brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|liver(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					caccaccaccaccaccaccac	0.597000													9	75					0	0	1	0	0
C10orf2	56652	broad.mit.edu	37	10	102748581	102748581	+	Missense_Mutation	SNP	T	T	G			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr10:102748581T>G	ENST00000370228.1	+	1	799	c.614T>G	c.(613-615)gTc>gGc	p.V205G	C10orf2_ENST00000311916.2_Missense_Mutation_p.V205G|C10orf2_ENST00000473656.1_Intron	NM_001163812.1|NM_001163814.1	NP_001157284.1|NP_001157286.1	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	205					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		CGCAGTCTTGTCTTCCCTTGG	0.527000													33	36					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132229980	132229980	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr3:132229980A>G	ENST00000260818.6	+	44	5433	c.5185A>G	c.(5185-5187)Atg>Gtg	p.M1729V		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1729							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						GCACACATTCATGGCCATCAC	0.433000													61	85					0	0	1	0	0
GDNF	2668	broad.mit.edu	37	5	37815925	37815925	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr5:37815925G>A	ENST00000326524.2	-	3	663	c.464C>T	c.(463-465)aCg>aTg	p.T155M	GDNF_ENST00000515058.1_Missense_Mutation_p.T129M|GDNF_ENST00000344622.4_Missense_Mutation_p.T129M|GDNF_ENST00000381826.4_Missense_Mutation_p.T146M|GDNF_ENST00000427982.1_Missense_Mutation_p.T172M	NM_000514.3	NP_000505.1	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor	155					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity			NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(8)|skin(2)	15	all_lung(31;0.00118)					TTTGTCGTACGTTGTCTCAGC	0.453000													4	107					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35864536	35864536	+	Nonsense_Mutation	SNP	T	T	A			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr13:35864536T>A	ENST00000540320.1	+	35	6321	c.5787T>A	c.(5785-5787)tgT>tgA	p.C1929*	NBEA_ENST00000310336.4_Nonsense_Mutation_p.C1929*|NBEA_ENST00000400445.3_Nonsense_Mutation_p.C1929*|NBEA_ENST00000379939.2_Nonsense_Mutation_p.C1926*			Q8NFP9	NBEA_HUMAN	neurobeachin	1929						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GCCTTGTTTGTATGAAGTCCA	0.303000													88	117					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64640262	64640262	+	Missense_Mutation	SNP	T	T	G			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr3:64640262T>G	ENST00000498707.1	-	7	1538	c.1196A>C	c.(1195-1197)aAa>aCa	p.K399T	ADAMTS9_ENST00000459780.1_Missense_Mutation_p.K399T|ADAMTS9_ENST00000295903.4_Missense_Mutation_p.K371T	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	399	Peptidase M12B.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGTATCACATTTGTCGTGAGC	0.383000													4	85					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113802568	113802568	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr11:113802568C>T	ENST00000260191.2	+	4	604	c.347C>T	c.(346-348)cCc>cTc	p.P116L	HTR3B_ENST00000537778.1_Missense_Mutation_p.P105L	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	116					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		ATCTGGGCCCCCGATATCATC	0.448000													27	66					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215896644	215896644	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr2:215896644G>A	ENST00000389661.4	-	1	166	c.8C>T	c.(7-9)aCc>aTc	p.T3I	AC072062.3_ENST00000437897.3_RNA|ABCA12_ENST00000272895.7_Intron	NM_015657.3	NP_056472.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	0					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTTTATATAGGTAAACATTTA	0.368000													5	57					0	0	1	0	0
AC006293.3	0	broad.mit.edu	37	19	55221559	55221559	+	RNA	SNP	G	G	T			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr19:55221559G>T	ENST00000413439.1	+	0	1339																											ACGGGGGCCAGTACAGATGCT	0.672000													5	68					3.59834e-05	3.77825e-05	1	1	0
TMEM132D	121256	broad.mit.edu	37	12	129569241	129569241	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr12:129569241C>G	ENST00000422113.2	-	6	1776	c.1450G>C	c.(1450-1452)Gac>Cac	p.D484H	TMEM132D_ENST00000389441.4_Missense_Mutation_p.D22H	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	484						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCACATCTGTCAGAAACCTGT	0.527000													4	27					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29005322	29005322	+	Silent	SNP	T	T	C			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr13:29005322T>C	ENST00000282397.4	-	7	1190	c.939A>G	c.(937-939)gtA>gtG	p.V313V	FLT1_ENST00000541932.1_Silent_p.V313V|FLT1_ENST00000539099.1_Silent_p.V313V	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	313	Ig-like C2-type 3.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GTCCACTCCTTACACGACAAG	0.378000													4	95					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128452273	128452273	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr7:128452273G>C	ENST00000297788.4	+	13	2815	c.2448G>C	c.(2446-2448)aaG>aaC	p.K816N	CCDC136_ENST00000464832.1_Intron|CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000487361.1_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	816	Ser-rich.					integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						CCTATAAGAAGAGTTACGGCA	0.517000													4	48					0	0	1	0	0
MMP7	4316	broad.mit.edu	37	11	102395783	102395783	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr11:102395783G>A	ENST00000260227.4	-	4	549	c.497C>T	c.(496-498)tCc>tTc	p.S166F		NM_002423.3	NP_002414.1	P09237	MMP7_HUMAN	matrix metallopeptidase 7 (matrilysin, uterine)	166					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		AAATGGGTAGGAGTCCCCATG	0.458000													4	43					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105419219	105419219	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr14:105419219C>T	ENST00000333244.5	-	7	2688	c.2569G>A	c.(2569-2571)Gat>Aat	p.D857N	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	857						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCAGACACATCCACCGAGTCC	0.597000													8	415					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39379332	39379332	+	Silent	SNP	C	C	A			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr7:39379332C>A	ENST00000518318.2	+	5	645	c.603C>A	c.(601-603)acC>acA	p.T201T	POU6F2_ENST00000403058.1_Silent_p.T201T|POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000559001.1_Silent_p.T193T			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	201	Gln-rich.|Pro-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						CCCCGTCAACCAACCAGCACC	0.682000													10	13					0.000673444	0.000689869	1	1	0
PIH1D2	120379	broad.mit.edu	37	11	111941848	111941848	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr11:111941848C>G	ENST00000530641.1	-	4	786	c.461G>C	c.(460-462)aGa>aCa	p.R154T	PIH1D2_ENST00000280350.4_Missense_Mutation_p.R154T|PIH1D2_ENST00000532211.1_Missense_Mutation_p.R154T|PIH1D2_ENST00000431456.1_Missense_Mutation_p.R154T|PIH1D2_ENST00000528775.1_Missense_Mutation_p.R154T			Q8WWB5	PIHD2_HUMAN	PIH1 domain containing 2	154										endometrium(2)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	11		all_cancers(61;1.09e-14)|all_epithelial(67;7.64e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.19e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;6.18e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0508)		TCCTTTTATTCTAAATTTGGT	0.338000													8	80					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43619150	43619150	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr10:43619150G>A	ENST00000355710.3	+	17	3065	c.2833G>A	c.(2833-2835)Gtg>Atg	p.V945M	RET_ENST00000340058.5_Missense_Mutation_p.V945M	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	945	Protein kinase.				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	GTGGGAGATCGTGACCCTAGG	0.607000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				78	103					0	0	1	0	0
MUC20	200958	broad.mit.edu	37	3	195453270	195453270	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr3:195453270C>G	ENST00000320736.6	+	3	1409	c.1283C>G	c.(1282-1284)cCc>cGc	p.P428R	MUC20_ENST00000445522.2_Missense_Mutation_p.P564R|MUC20_ENST00000447234.2_Missense_Mutation_p.P599R|MUC20_ENST00000436408.1_Missense_Mutation_p.P599R	NM_001098516.1|NM_152673.2	NP_001091986.1|NP_689886.2	Q8N307	MUC20_HUMAN	mucin 20, cell surface associated	599					protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane				NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)	23	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		ACCAAGGGGCCCTTCCCCACC	0.597000													14	38					0	0	1	0	0
SDHAP1	0	broad.mit.edu	37	3	195717061	195717061	+	RNA	SNP	C	C	A			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr3:195717061C>A	ENST00000427841.1	-	0	89					NR_003264.2																						AGGGACTCACCGCCTTGGCCA	0.791000													4	15					0.014758	0.014758	1	1	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				28	49					0	0	1	0	0
NECAP1	25977	broad.mit.edu	37	12	8244414	8244414	+	Silent	SNP	C	C	T			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr12:8244414C>T	ENST00000339754.5	+	4	429	c.351C>T	c.(349-351)ttC>ttT	p.F117F		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	117					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		GAGATGCCTTCGACTTTAATG	0.483000													9	17					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659734	24659734	+	RNA	SNP	T	T	C			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr22:24659734T>C	ENST00000414583.2	+	0	3259					NR_003714.1																						CTCTCTCCTGTGGGAGGGGGG	0.632000													5	14					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16946471	16946471	+	RNA	SNP	G	G	C			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr1:16946471G>C	ENST00000412962.1	-	0	1048																											CGCTGCAGCTGACTCTGCAGC	0.677000													3	25					0	0	1	0	0
LINC00971	0	broad.mit.edu	37	3	84741479	84741480	+	RNA	INS	-	-	AA	rs59143453		TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr3:84741479_84741480insAA	ENST00000484892.1	-	0	2354					NR_033860.1																						ACCTGTCCCAGAAAAAAAAAAA	0.386													2	4	---	---	---	---					
AC090505.6	0	broad.mit.edu	37	3	194478104	194478104	+	RNA	DEL	C	C	-			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr3:194478104delC	ENST00000423318.1	+	0	940					NR_037891.1																						CTACACGCTGCCCCAGGGGTA	0.622													2	4	---	---	---	---					
CRIPAK	285464	broad.mit.edu	37	4	1388441	1388442	+	Frame_Shift_Ins	INS	-	-	CG	rs144787346	byFrequency	TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr4:1388441_1388442insCG	ENST00000324803.4	+	1	3102_3103	c.142_143insCG	c.(142-144)gccfs	p.A48fs		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	48					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CTGCTCACACATGCCCATGTGG	0.644													8	598	---	---	---	---					
ABCA13	154664	broad.mit.edu	37	7	48315944	48315944	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr7:48315944delA	ENST00000435803.1	+	17	6705	c.6681delA	c.(6679-6681)ttfs	p.L2227fs		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2227					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CTTGGAACTTAAATGATACTG	0.348													2	4	---	---	---	---					
KRTAP5-2	440021	broad.mit.edu	37	11	1619173	1619202	+	In_Frame_Del	DEL	CCCCCACAGGAGCCACAGCCCCCCTTGGAG	CCCCCACAGGAGCCACAGCCCCCCTTGGAG	-	rs61869706	by1000genomes	TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr11:1619173_1619202delCCCCCACAGGAGCCACAGCCCCCCTTGGAG	ENST00000412090.1	-	1	322_351	c.279_308delCTCCAAGGGGGGCTGTGGCTCCTGTGGGGG	c.(277-309)ggt>gg	p.GSKGGCGSCGG93del	KRTAP5-AS1_ENST00000424148.1_RNA	NM_001004325.1	NP_001004325.1	Q701N4	KRA52_HUMAN	keratin associated protein 5-2	93	6 X 4 AA repeats of C-C-X-P.					keratin filament				large_intestine(1)|lung(2)|skin(1)	4		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCCCTTGGAACCCCCACAGGAGCCACAGCCCCCCTTGGAGCCCCCACAGG	0.657													53	337	---	---	---	---					
TPTE2P1	0	broad.mit.edu	37	13	25527490	25527491	+	RNA	INS	-	-	AAAAAG			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr13:25527490_25527491insAAAAAG	ENST00000429698.1	-	0	282																											AGGAAGGTTCTAAAAAAAATTT	0.252													4	5	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20138376	20138376	+	RNA	DEL	G	G	-	rs57620493		TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr14:20138376delG	ENST00000548261.1	+	0	391																											ACAaaagaaagaaagaaagaa	0.388													3	3	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102292874	102292876	+	RNA	DEL	CTC	CTC	-			TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr15:102292874_102292876delCTC	ENST00000561463.1	+	0	920_922																											AGTTCATCTTCTCAGAGCTGCTG	0.581													4	9	---	---	---	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	In_Frame_Del	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	rs483929	by1000genomes	TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	ENST00000398472.1	-	1	742_798	c.255_311delCCCACTCTGCTGTCAGACCACCTGCCACCCCAGCTGTGGTATGTCCAGCTGCTGCCG	c.(253-312)cgt>cg	p.RPLCCQTTCHPSCGMSSCCR85del				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	85	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].		Missing (in allele KAP4.10).			keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													88	42	---	---	---	---					
C21orf58	54058	broad.mit.edu	37	21	47721985	47721986	+	In_Frame_Ins	INS	-	-	TGG	rs144223236	by1000genomes	TCGA-DJ-A3VI-01A-11D-A23M-08	TCGA-DJ-A3VI-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ed007d5-19d3-47c8-8c00-463e6be91687	f3358525-8de5-4245-b89b-fd0be1e1d13e	g.chr21:47721985_47721986insTGG	ENST00000291691.7	-	8	2032_2033	c.896_897insCCA	c.(895-897)cgc>cCCAgc	p.299_299R>PS	C21orf58_ENST00000397679.1_In_Frame_Ins_p.193_193R>PS|C21orf58_ENST00000397683.1_In_Frame_Ins_p.193_193R>PS|C21orf58_ENST00000472607.1_5'UTR|C21orf58_ENST00000397680.1_In_Frame_Ins_p.193_193R>PS|C21orf58_ENST00000397682.3_In_Frame_Ins_p.193_193R>PS	NM_058180.3	NP_478060.2	P58505	CU058_HUMAN	chromosome 21 open reading frame 58	299	Poly-His.							p.H299_A300insH(3)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(1)|pancreas(1)	9	Breast(49;0.112)			Colorectal(79;0.239)		GCCACACAGCAtggtggtggtg	0.708													4	4	---	---	---	---					
