Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MYLK	4638	broad.mit.edu	37	3	123345769	123345769	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr3:123345769G>A	ENST00000360772.3	-	31	5359	c.4981C>T	c.(4981-4983)Cag>Tag	p.Q1661*	MYLK_ENST00000346322.5_Nonsense_Mutation_p.Q1643*|MYLK_ENST00000359169.1_Nonsense_Mutation_p.Q1661*|MYLK-AS1_ENST00000463408.1_RNA|MYLK_ENST00000360304.3_Nonsense_Mutation_p.Q1712*|MYLK_ENST00000354792.5_Nonsense_Mutation_p.Q512*|MYLK-AS1_ENST00000470449.1_RNA|MYLK-AS1_ENST00000485162.1_RNA|MYLK_ENST00000475616.1_Nonsense_Mutation_p.Q1712*			Q15746	MYLK_HUMAN	myosin light chain kinase	1712	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGAAGGCACTGCGTGCAGTCC	0.502000													6	72					0	0	1	0	0
SNRK	54861	broad.mit.edu	37	3	43345283	43345283	+	Splice_Site	SNP	A	A	T			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr3:43345283A>T	ENST00000296088.7	+	3	892	c.589_splice	c.e3+1	p.V196_splice	SNRK_ENST00000462810.1_3'UTR|SNRK_ENST00000454177.1_Splice_Site_p.V196_splice|SNRK_ENST00000429705.2_Splice_Site_p.V196_splice|SNRK_ENST00000437827.1_Intron	NM_017719.4	NP_060189.3	Q9NRH2	SNRK_HUMAN	SNF related kinase	196	Protein kinase.			V -> A (in Ref. 7; CAH18415).	myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(5)|prostate(1)|skin(2)|stomach(1)	27				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		CACCTGCAGTAGGTAGGTAAC	0.423000													51	91					0	0	1	0	0
CNOT10	25904	broad.mit.edu	37	3	32778913	32778913	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr3:32778913A>G	ENST00000328834.5	+	13	1842	c.1526A>G	c.(1525-1527)cAt>cGt	p.H509R	CNOT10_ENST00000454516.2_Missense_Mutation_p.H569R|CNOT10_ENST00000331889.6_Intron|CNOT10-AS1_ENST00000475395.2_RNA|CNOT10_ENST00000538368.1_Missense_Mutation_p.H281R	NM_015442.2	NP_056257.1	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	509				H -> Y (in Ref. 1; BAB14108).	nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(3)	23						AGTAAAAGCCATGATGGAGAT	0.323000													36	75					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8141916	8141916	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr17:8141916G>A	ENST00000315684.8	-	3	236	c.229C>T	c.(229-231)Cag>Tag	p.Q77*	CTC1_ENST00000581671.1_5'UTR	NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	77					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						GGGAGACGCTGGTGAGTCTTG	0.592000													70	84					0	0	1	0	0
MOGAT3	346606	broad.mit.edu	37	7	100841499	100841499	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr7:100841499C>G	ENST00000223114.4	-	5	807	c.641G>C	c.(640-642)gGc>gCc	p.G214A	MOGAT3_ENST00000440203.2_Missense_Mutation_p.G214A|MOGAT3_ENST00000379423.3_Missense_Mutation_p.G214A	NM_178176.2	NP_835470.1	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	214					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					GCGCACGAAGCCTTTGCGCTT	0.647000													35	47					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40716160	40716160	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr12:40716160C>G	ENST00000298910.7	+	37	5415	c.5357C>G	c.(5356-5358)tCt>tGt	p.S1786C		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1786					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding	p.S1749F(1)|p.S1786F(1)		NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CACATTGATTCTCTCATGGAA	0.398000													149	253					0	0	1	0	0
EIF3G	8666	broad.mit.edu	37	19	10225802	10225802	+	Silent	SNP	C	C	T			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr19:10225802C>T	ENST00000253108.4	-	11	993	c.951G>A	c.(949-951)ccG>ccA	p.P317P	P2RY11_ENST00000321826.4_3'UTR	NM_003755.3	NP_003746.2	O75821	EIF3G_HUMAN	eukaryotic translation initiation factor 3, subunit G	317	RRM.					cytosol|eukaryotic translation initiation factor 3 complex|nucleus|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity			central_nervous_system(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(20;3.53e-09)|Epithelial(33;4.91e-06)|all cancers(31;1.1e-05)			AGTTGGTGGACGGCCTGGGGT	0.637000													13	17					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133883768	133883768	+	Silent	SNP	G	G	T			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr8:133883768G>T	ENST00000220616.4	+	4	490	c.450G>T	c.(448-450)ggG>ggT	p.G150G	TG_ENST00000377869.1_Silent_p.G150G	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	150	Thyroglobulin type-1 2.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGGTGTATGGGACCCGCCAGC	0.607000													17	37					1.45105e-14	1.53167e-14	1	1	0
FRG1B	0	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N|FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													12	150					0	0	1	0	0
NUP133	55746	broad.mit.edu	37	1	229606430	229606430	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr1:229606430G>A	ENST00000261396.3	-	15	2064	c.1973C>T	c.(1972-1974)tCc>tTc	p.S658F	NUP133_ENST00000537506.1_Missense_Mutation_p.S642F|NUP133_ENST00000366679.1_Missense_Mutation_p.S658F	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	658					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				AGAAAGCCGGGAGTGGTGGTT	0.502000													17	129					0	0	1	0	0
TBRG4	9238	broad.mit.edu	37	7	45148648	45148648	+	Silent	SNP	T	T	C			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr7:45148648T>C	ENST00000258770.3	-	2	310	c.189A>G	c.(187-189)gcA>gcG	p.A63A	TBRG4_ENST00000471142.1_5'UTR|TBRG4_ENST00000395655.4_Silent_p.A63A|TBRG4_ENST00000494076.1_Silent_p.A63A|TBRG4_ENST00000361278.3_Silent_p.A63A	NM_004749.3	NP_004740.2	Q969Z0	TBRG4_HUMAN	transforming growth factor beta regulator 4	63					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(2)	17						AGGGAGTAGATGCTCGTTCCT	0.562000													5	136					0	0	1	0	0
SH2D3A	10045	broad.mit.edu	37	19	6754188	6754188	+	Missense_Mutation	SNP	T	T	C	rs2305807	by1000genomes	TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr19:6754188T>C	ENST00000437152.3	-	6	1112	c.980A>G	c.(979-981)gAt>gGt	p.D327G	SH2D3A_ENST00000245908.6_Intron			Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	425					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|urinary_tract(1)	24						GGAGAAGAGATCTGAGCACGC	0.657000													3	23					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156631708	156631708	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr4:156631708G>C	ENST00000296518.7	+	6	600	c.391G>C	c.(391-393)Gtt>Ctt	p.V131L	GUCY1A3_ENST00000515602.1_3'UTR|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.V131L|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.V131L|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.V131L|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.V131L|GUCY1A3_ENST00000511108.1_Missense_Mutation_p.V131L|GUCY1A3_ENST00000393832.3_5'UTR			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	131				VIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLK QSSHCQEAGKRGR -> LSKNLLVKRFLKYVTRKMKTSLGW LEAPLKIFKQLQYPSETEQPLPRSRKKGQ (in Ref. 1).	blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TCCAGTGGAGGTTATCAAAGA	0.373000													29	51					0	0	1	0	0
HBBP1	0	broad.mit.edu	37	11	5264339	5264339	+	RNA	SNP	G	G	T			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr11:5264339G>T	ENST00000454892.1	-	0	157					NR_001589.1																						TACTCACCAGGAAGTTCTCAG	0.463000													11	12					3.86212e-05	3.9665e-05	1	1	0
POLR3B	55703	broad.mit.edu	37	12	106820987	106820987	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr12:106820987C>T	ENST00000228347.4	+	13	1336	c.1114C>T	c.(1114-1116)Ctt>Ttt	p.L372F	POLR3B_ENST00000539066.1_Missense_Mutation_p.L314F|POLR3B_ENST00000549195.1_3'UTR	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	372					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding	p.L372F(2)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						TTTATCTCTTCTTTTTGAAGA	0.274000													7	32					0	0	1	0	0
KCNIP4	80333	broad.mit.edu	37	4	20751329	20751329	+	Missense_Mutation	SNP	A	A	C			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr4:20751329A>C	ENST00000382148.3	-	4	646	c.310T>G	c.(310-312)Ttc>Gtc	p.F104V	KCNIP4_ENST00000382149.4_5'UTR|KCNIP4_ENST00000359001.5_Missense_Mutation_p.F67V|PACRGL_ENST00000507634.1_Intron|KCNIP4_ENST00000509207.1_Missense_Mutation_p.F67V|KCNIP4_ENST00000447367.2_Missense_Mutation_p.F95V|KCNIP4_ENST00000382150.4_Missense_Mutation_p.F108V|KCNIP4_ENST00000382152.2_Missense_Mutation_p.F129V	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	129	EF-hand 1; degenerate.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				AATGCATTGAACAGAAAATGT	0.358000													7	65					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135073480	135073480	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr9:135073480G>T	ENST00000393229.3	+	3	1117	c.341G>T	c.(340-342)cGc>cTc	p.R114L	NTNG2_ENST00000360670.3_Missense_Mutation_p.R114L|NTNG2_ENST00000393228.4_Missense_Mutation_p.R114L|NTNG2_ENST00000372179.3_Missense_Mutation_p.R114L	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	114	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		ACCTGGAGCCGCTACCCCAGC	0.652000													29	52					3.11337e-16	3.38024e-16	1	1	0
HERC1	8925	broad.mit.edu	37	15	63937682	63937682	+	Splice_Site	SNP	G	G	A			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr15:63937682G>A	ENST00000443617.2	-	56	11165	c.11078_splice	c.e56+1	p.T3693_splice		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	3693					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GACAACATACGTAGCCATCAG	0.403000													3	42					0	0	1	0	0
MMP24	10893	broad.mit.edu	37	20	33834779	33834779	+	Missense_Mutation	SNP	A	A	C			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr20:33834779A>C	ENST00000246186.6	+	2	468	c.383A>C	c.(382-384)cAg>cCg	p.Q128P	EDEM2_ENST00000540582.1_Intron|MMP24-AS1_ENST00000456350.1_RNA|MMP24-AS1_ENST00000454184.1_RNA|MMP24-AS1_ENST00000566203.1_RNA|MMP24-AS1_ENST00000438751.1_RNA|MMP24-AS1_ENST00000433764.1_RNA	NM_006690.3	NP_006681.1	Q9Y5R2	MMP24_HUMAN	matrix metallopeptidase 24 (membrane-inserted)	128					proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(3)|large_intestine(1)|lung(2)|prostate(2)|skin(5)	14			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GTGTTGGATCAGACAACGATC	0.522000													7	107					0	0	1	0	0
PSPH	5723	broad.mit.edu	37	7	56079524	56079524	+	Silent	SNP	T	T	C			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr7:56079524T>C	ENST00000395471.3	-	8	1414	c.609A>G	c.(607-609)caA>caG	p.Q203Q	PSPH_ENST00000275605.3_Silent_p.Q203Q|PSPH_ENST00000459834.1_5'UTR			P78330	SERB_HUMAN	phosphoserine phosphatase	203					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(1)|skin(1)	11	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CCTTGACTTGTTGCCTGATCA	0.348000													11	170					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37299605	37299605	+	Silent	SNP	G	G	A	rs149980171	by1000genomes	TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr5:37299605G>A	ENST00000231498.3	-	31	3830	c.3627C>T	c.(3625-3627)gcC>gcT	p.A1209A	NUP155_ENST00000381843.2_Silent_p.A1150A|NUP155_ENST00000502533.1_5'UTR|NUP155_ENST00000513532.1_Silent_p.A1145A	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	1209					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTGAATAACCGGCACAATGAA	0.378000													5	120					0	0	1	0	0
FOXO3	2309	broad.mit.edu	37	6	108984910	108984910	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr6:108984910C>T	ENST00000406360.1	+	2	1217	c.874C>T	c.(874-876)Cct>Tct	p.P292S	FOXO3_ENST00000343882.6_Missense_Mutation_p.P292S|FOXO3_ENST00000540898.1_Missense_Mutation_p.P72S	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	292				PGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMAS -> AWQPHVNAAVMSWMRGRTSVHAPILTPAQSVAACRPSW QV (in Ref. 5; CAA04860).	antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		CTCCAAGTGGCCTGGCAGCCC	0.622000													3	25					0	0	1	0	0
CPA2	1358	broad.mit.edu	37	7	129906739	129906739	+	Silent	SNP	C	C	T			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr7:129906739C>T	ENST00000222481.4	+	1	73	c.18C>T	c.(16-18)atC>atT	p.I6I		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	6					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					TGAGGTTGATCCTGTTTTTTG	0.443000													76	122					0	0	1	0	0
XPA	7507	broad.mit.edu	37	9	100455962	100455964	+	In_Frame_Del	DEL	TTC	TTC	-	rs3176652		TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr9:100455962_100455964delTTC	ENST00000375128.4	-	2	314_316	c.250_252delGAA	c.(250-252)del	p.E84del		NM_000380.3	NP_000371.1	P23025	XPA_HUMAN	xeroderma pigmentosum, complementation group A	84	Interaction with CEP164 and required for UV resistance.|Poly-Glu.				nucleotide-excision repair, DNA damage removal	nucleoplasm	damaged DNA binding|metal ion binding|nucleotide binding|protein domain specific binding|protein homodimerization activity	p.E84*(1)		breast(1)|endometrium(4)|large_intestine(1)|lung(4)|prostate(1)	11		Acute lymphoblastic leukemia(62;0.158)				CAATTTTCTGTTCTTCTTCTTCT	0.340			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				7	123	---	---	---	---					
AC126365.1	0	broad.mit.edu	37	17	20623668	20623668	+	RNA	DEL	T	T	-	rs151078009		TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr17:20623668delT	ENST00000578210.1	+	0	150					NR_073509.1																						gcccggctaattttttttttt	0.572													4	5	---	---	---	---					
ATP9B	374868	broad.mit.edu	37	18	76936903	76936904	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr18:76936903_76936904delTG	ENST00000426216.2	+	8	886_887	c.869_870delTG	c.(868-870)cfs	p.L290fs	ATP9B_ENST00000307671.7_Frame_Shift_Del_p.L290fs	NM_198531.3	NP_940933.3	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	290					ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(3)|prostate(1)|skin(2)|stomach(1)	38		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		CTGCCGGCTCTGGGGGTGAGCA	0.441													51	102	---	---	---	---					
CBR3	874	broad.mit.edu	37	21	37510175	37510175	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DJ-A3VM-01A-11D-A23M-08	TCGA-DJ-A3VM-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	84aaa406-6753-4374-9b89-fd6e1fa366d5	7c207e1e-48ae-4299-af8c-1e95033b467b	g.chr21:37510175delT	ENST00000290354.5	+	2	623	c.342delT	c.(340-342)aafs	p.N114fs	CBR3-AS1_ENST00000453159.1_RNA|CBR3-AS1_ENST00000413862.1_RNA	NM_001236.3	NP_001227.1	O75828	CBR3_HUMAN	carbonyl reductase 3	114						cytosol|nucleus	carbonyl reductase (NADPH) activity|NADPH binding			kidney(1)|large_intestine(1)|lung(1)	3						TGAAGACAAATTTTTTTGCCA	0.408													10	252	---	---	---	---					
