Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PPP1R3F	89801	broad.mit.edu	37	X	49127085	49127085	+	Silent	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chrX:49127085G>A	ENST00000055335.6	+	1	769	c.753G>A	c.(751-753)gaG>gaA	p.E251E	PPP1R3F_ENST00000495799.1_Intron|PPP1R3F_ENST00000466508.1_5'UTR|PPP1R3F_ENST00000438316.1_5'UTR	NM_033215.4	NP_149992.3	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory subunit 3F	251	CBM21.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(4)	27	Ovarian(276;0.236)					CCTTTGCTGAGGGCGCGGGCG	0.701000													3	28					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249646	52249646	+	Missense_Mutation	SNP	C	C	G			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr19:52249646C>G	ENST00000595042.1	-	3	743	c.602G>C	c.(601-603)aGa>aCa	p.R201T	FPR1_ENST00000304748.4_Missense_Mutation_p.R201T	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	201					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GATGATGCCTCTCACCGTCAA	0.507000													6	90					0	0	1	0	0
GPSM3	63940	broad.mit.edu	37	6	32159644	32159644	+	Missense_Mutation	SNP	C	C	T			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr6:32159644C>T	ENST00000375040.3	-	3	579	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	GPSM3_ENST00000375043.3_Missense_Mutation_p.E63K|GPSM3_ENST00000487761.1_Missense_Mutation_p.E60K	NM_001276501.1	NP_001263430.1	Q9Y4H4	GPSM3_HUMAN	G-protein signaling modulator 3	63	GoLoco 1.				signal transduction	cytoplasm	GTPase activator activity|protein binding			large_intestine(1)	1						AGAAGGAGTTCAGTCTGCAGG	0.672000													4	60					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	406991	406991	+	Missense_Mutation	SNP	C	C	T			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr9:406991C>T	ENST00000432829.2	+	28	3564	c.3248C>T	c.(3247-3249)tCc>tTc	p.S1083F	DOCK8_ENST00000453981.1_Missense_Mutation_p.S1151F|DOCK8_ENST00000469391.1_Missense_Mutation_p.S1051F|DOCK8_ENST00000382329.1_Missense_Mutation_p.S618F	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1151					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GATCTGACTTCCGAGTACCGC	0.522000													7	120					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9449316	9449316	+	Missense_Mutation	SNP	A	A	G			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr20:9449316A>G	ENST00000378501.2	+	32	3326	c.3311A>G	c.(3310-3312)gAa>gGa	p.E1104G	PLCB4_ENST00000278655.4_Missense_Mutation_p.E1104G|PLCB4_ENST00000378473.3_Missense_Mutation_p.E1116G|PLCB4_ENST00000414679.2_Missense_Mutation_p.E1116G|PLCB4_ENST00000378493.1_Missense_Mutation_p.E1104G|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000334005.3_Missense_Mutation_p.E1104G	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	1104					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						GCAGAACGGGAAAGGTAAGTC	0.423000													16	52					0	0	1	0	0
PCDHB17	0	broad.mit.edu	37	5	140537004	140537004	+	Silent	SNP	C	C	T	rs246697		TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr5:140537004C>T	ENST00000539533.1	+	1	1428	c.1428C>T	c.(1426-1428)gcC>gcT	p.A476A																								GTGTCAGCGCCACAGACAGAG	0.642000													8	195					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113553841	113553841	+	Silent	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr12:113553841G>A	ENST00000546530.1	-	10	1032	c.747C>T	c.(745-747)gcC>gcT	p.A249A	RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000548055.1_Silent_p.A249A|RASAL1_ENST00000261729.5_Silent_p.A249A|RASAL1_ENST00000446861.3_Silent_p.A249A	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	249					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						TCACTCGCAGGGCACCCAGGT	0.582000													4	58					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113553842	113553842	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr12:113553842G>A	ENST00000546530.1	-	10	1031	c.746C>T	c.(745-747)gCc>gTc	p.A249V	RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000548055.1_Missense_Mutation_p.A249V|RASAL1_ENST00000261729.5_Missense_Mutation_p.A249V|RASAL1_ENST00000446861.3_Missense_Mutation_p.A249V	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	249					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						CACTCGCAGGGCACCCAGGTT	0.577000													4	57					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123630900	123630900	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chrX:123630900G>A	ENST00000422452.2	-	20	3724	c.3661C>T	c.(3661-3663)Ccc>Tcc	p.P1221S	TENM1_ENST00000371130.3_Missense_Mutation_p.P1221S|TENM1_ENST00000461429.1_5'UTR	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TTTCCCGAGGGAAATATTCTC	0.398000													4	60					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106734726	106734726	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr12:106734726G>A	ENST00000299045.3	+	9	1439	c.1265G>A	c.(1264-1266)gGt>gAt	p.G422D		NM_152772.1	NP_689985.1	Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	422										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						AATCTTATAGGTCAATTTTCA	0.373000													9	126					0	0	1	0	0
CHAF1B	8208	broad.mit.edu	37	21	37785504	37785504	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr21:37785504G>A	ENST00000314103.4	+	12	1535	c.1384G>A	c.(1384-1386)Ggg>Agg	p.G462R		NM_005441.2	NP_005432.1	Q13112	CAF1B_HUMAN	chromatin assembly factor 1, subunit B (p60)	462					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(2)	20						CCCCTTGCCGGGGCCTTCGGA	0.627000													4	31					0	0	1	0	0
TLR8	51311	broad.mit.edu	37	X	12940129	12940129	+	Missense_Mutation	SNP	G	G	C			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chrX:12940129G>C	ENST00000218032.6	+	2	3057	c.2970G>C	c.(2968-2970)ttG>ttC	p.L990F	TLR8_ENST00000311912.5_Missense_Mutation_p.L1008F	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	990	TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CTCAGTATTTGAGGCTACGGC	0.463000													6	113					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137801382	137801382	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr7:137801382G>A	ENST00000242375.3	+	9	997	c.955G>A	c.(955-957)Gaa>Aaa	p.E319K	AKR1D1_ENST00000411726.2_Missense_Mutation_p.E278K|AKR1D1_ENST00000432161.1_Silent_p.*291*|AKR1D1_ENST00000468877.2_3'UTR	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	319					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						CGATCATCCTGAATACCCATT	0.443000													6	65					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	406992	406992	+	Silent	SNP	C	C	T			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr9:406992C>T	ENST00000432829.2	+	28	3565	c.3249C>T	c.(3247-3249)tcC>tcT	p.S1083S	DOCK8_ENST00000453981.1_Silent_p.S1151S|DOCK8_ENST00000469391.1_Silent_p.S1051S|DOCK8_ENST00000382329.1_Silent_p.S618S	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1151					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ATCTGACTTCCGAGTACCGCC	0.527000													7	120					0	0	1	0	0
NDUFA9	4704	broad.mit.edu	37	12	4771757	4771757	+	Missense_Mutation	SNP	C	C	T			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr12:4771757C>T	ENST00000266544.5	+	6	631	c.611C>T	c.(610-612)tCg>tTg	p.S204L		NM_005002.4	NP_004993.1	Q16795	NDUA9_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	204					mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21					NADH(DB00157)	GTAAAGCCGTCGGACATCTTT	0.388000													7	127					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70249984	70249984	+	Missense_Mutation	SNP	C	C	T	rs34479874		TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr7:70249984C>T	ENST00000342771.4	+	16	2524	c.2203C>T	c.(2203-2205)Ctc>Ttc	p.L735F	AUTS2_ENST00000406775.2_Missense_Mutation_p.L711F	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	735										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CAGCAACTTCCTCAACCCTGC	0.517000													4	59					0	0	1	0	0
FAM78A	286336	broad.mit.edu	37	9	134136313	134136313	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr9:134136313G>A	ENST00000372271.3	-	2	1115	c.748C>T	c.(748-750)Ccg>Tcg	p.P250S	FAM78A_ENST00000247295.4_5'UTR|FAM78A_ENST00000372269.3_Missense_Mutation_p.P247S	NM_033387.3	NP_203745.2	Q5JUQ0	FA78A_HUMAN	family with sequence similarity 78, member A	250										NS(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		GCGCTGGGCGGGATGGGCTCA	0.687000													6	116					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	93798	93798	+	Silent	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr10:93798G>A	ENST00000447903.2	-	4	633	c.318C>T	c.(316-318)acC>acT	p.T106T	TUBB8_ENST00000332708.5_3'UTR|TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000309812.4_Silent_p.T178T			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	178					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GCTCCACCACGGTGTCCGACA	0.522000													16	113					0	0	1	0	0
RLIM	51132	broad.mit.edu	37	X	73812337	73812337	+	Missense_Mutation	SNP	C	C	G			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chrX:73812337C>G	ENST00000332687.6	-	4	1031	c.813G>C	c.(811-813)ttG>ttC	p.L271F	RLIM_ENST00000349225.2_Missense_Mutation_p.L271F	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	271					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTTGCTGCCTCAATGTCACAT	0.453000													8	117					0	0	1	0	0
AC093838.4	0	broad.mit.edu	37	2	132258593	132258593	+	RNA	SNP	A	A	G	rs13415770	by1000genomes	TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr2:132258593A>G	ENST00000438378.2	+	0	777					NR_026922.1																						CTGTACCACAACAAGGTCCAG	0.617000													3	23					0	0	1	0	0
FAM98C	147965	broad.mit.edu	37	19	38896057	38896057	+	Missense_Mutation	SNP	G	G	C			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr19:38896057G>C	ENST00000252530.5	+	5	648	c.629G>C	c.(628-630)aGa>aCa	p.R210T	FAM98C_ENST00000588262.1_Intron|FAM98C_ENST00000343358.7_Intron	NM_174905.3	NP_777565.3	Q17RN3	FA98C_HUMAN	family with sequence similarity 98, member C	210										endometrium(2)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GATGCACCCAGATGGGTAAGA	0.572000													4	57					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197298099	197298099	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr2:197298099G>A	ENST00000260983.2	-	2	231	c.49C>T	c.(49-51)Ccc>Tcc	p.P17S		NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	17					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						CGCATCTGGGGATTTCGACGC	0.577000													5	69					0	0	1	0	0
B3GNT8	374907	broad.mit.edu	37	19	41931682	41931682	+	Silent	SNP	G	G	A	rs142140890		TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr19:41931682G>A	ENST00000321702.2	-	3	1455	c.1002C>T	c.(1000-1002)gaC>gaT	p.D334D	CTC-435M10.6_ENST00000598887.1_RNA	NM_198540.2	NP_940942.1	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	334					poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity			cervix(1)|kidney(2)|large_intestine(1)|lung(5)|prostate(2)	11						CAGTGTAGACGTCCTCAAAGG	0.692000													4	53					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160087145	160087145	+	Missense_Mutation	SNP	G	G	C			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr2:160087145G>C	ENST00000263635.6	+	27	5445	c.5208G>C	c.(5206-5208)caG>caC	p.Q1736H	TANC1_ENST00000454300.1_Missense_Mutation_p.Q1630H	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	1736						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						TCCAACAGCAGAGCAATCCTC	0.577000													8	109					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				24	68					0	0	1	0	0
NSUN5P1	0	broad.mit.edu	37	7	75044463	75044463	+	RNA	SNP	G	G	A	rs71245954		TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr7:75044463G>A	ENST00000393633.2	+	0	3631																				large_intestine(1)|lung(1)	2						TGCCTGTGCCGCCCCAGGCAA	0.612000													3	32					0	0	1	0	0
PPP1R3F	89801	broad.mit.edu	37	X	49127085	49127085	+	Silent	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chrX:49127085G>A	ENST00000055335.6	+	1	769	c.753G>A	c.(751-753)gaG>gaA	p.E251E	PPP1R3F_ENST00000495799.1_Intron|PPP1R3F_ENST00000466508.1_5'UTR|PPP1R3F_ENST00000438316.1_5'UTR	NM_033215.4	NP_149992.3	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory subunit 3F	251	CBM21.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(4)	27	Ovarian(276;0.236)					CCTTTGCTGAGGGCGCGGGCG	0.701000													3	28					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249646	52249646	+	Missense_Mutation	SNP	C	C	G			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr19:52249646C>G	ENST00000595042.1	-	3	743	c.602G>C	c.(601-603)aGa>aCa	p.R201T	FPR1_ENST00000304748.4_Missense_Mutation_p.R201T	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	201					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GATGATGCCTCTCACCGTCAA	0.507000													6	90					0	0	1	0	0
GPSM3	63940	broad.mit.edu	37	6	32159644	32159644	+	Missense_Mutation	SNP	C	C	T			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr6:32159644C>T	ENST00000375040.3	-	3	579	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	GPSM3_ENST00000375043.3_Missense_Mutation_p.E63K|GPSM3_ENST00000487761.1_Missense_Mutation_p.E60K	NM_001276501.1	NP_001263430.1	Q9Y4H4	GPSM3_HUMAN	G-protein signaling modulator 3	63	GoLoco 1.				signal transduction	cytoplasm	GTPase activator activity|protein binding			large_intestine(1)	1						AGAAGGAGTTCAGTCTGCAGG	0.672000													4	60					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	406991	406991	+	Missense_Mutation	SNP	C	C	T			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr9:406991C>T	ENST00000432829.2	+	28	3564	c.3248C>T	c.(3247-3249)tCc>tTc	p.S1083F	DOCK8_ENST00000382329.1_Missense_Mutation_p.S618F|DOCK8_ENST00000469391.1_Missense_Mutation_p.S1051F|DOCK8_ENST00000453981.1_Missense_Mutation_p.S1151F	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1151					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GATCTGACTTCCGAGTACCGC	0.522000													7	120					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9449316	9449316	+	Missense_Mutation	SNP	A	A	G			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr20:9449316A>G	ENST00000378501.2	+	32	3326	c.3311A>G	c.(3310-3312)gAa>gGa	p.E1104G	PLCB4_ENST00000334005.3_Missense_Mutation_p.E1104G|PLCB4_ENST00000278655.4_Missense_Mutation_p.E1104G|PLCB4_ENST00000378473.3_Missense_Mutation_p.E1116G|PLCB4_ENST00000414679.2_Missense_Mutation_p.E1116G|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378493.1_Missense_Mutation_p.E1104G	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	1104					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						GCAGAACGGGAAAGGTAAGTC	0.423000													16	52					0	0	1	0	0
PCDHB17	0	broad.mit.edu	37	5	140537004	140537004	+	Silent	SNP	C	C	T	rs246697		TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr5:140537004C>T	ENST00000539533.1	+	1	1428	c.1428C>T	c.(1426-1428)gcC>gcT	p.A476A																								GTGTCAGCGCCACAGACAGAG	0.642000													8	195					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113553841	113553841	+	Silent	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr12:113553841G>A	ENST00000546530.1	-	10	1032	c.747C>T	c.(745-747)gcC>gcT	p.A249A	RASAL1_ENST00000548055.1_Silent_p.A249A|RASAL1_ENST00000261729.5_Silent_p.A249A|RASAL1_ENST00000446861.3_Silent_p.A249A|RASAL1_ENST00000418411.2_5'UTR	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	249					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						TCACTCGCAGGGCACCCAGGT	0.582000													4	58					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113553842	113553842	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr12:113553842G>A	ENST00000546530.1	-	10	1031	c.746C>T	c.(745-747)gCc>gTc	p.A249V	RASAL1_ENST00000548055.1_Missense_Mutation_p.A249V|RASAL1_ENST00000261729.5_Missense_Mutation_p.A249V|RASAL1_ENST00000446861.3_Missense_Mutation_p.A249V|RASAL1_ENST00000418411.2_5'UTR	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	249					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						CACTCGCAGGGCACCCAGGTT	0.577000													4	57					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123630900	123630900	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chrX:123630900G>A	ENST00000422452.2	-	20	3724	c.3661C>T	c.(3661-3663)Ccc>Tcc	p.P1221S	TENM1_ENST00000371130.3_Missense_Mutation_p.P1221S|TENM1_ENST00000461429.1_5'UTR	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TTTCCCGAGGGAAATATTCTC	0.398000													4	60					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106734726	106734726	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr12:106734726G>A	ENST00000299045.3	+	9	1439	c.1265G>A	c.(1264-1266)gGt>gAt	p.G422D		NM_152772.1	NP_689985.1	Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	422										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						AATCTTATAGGTCAATTTTCA	0.373000													9	126					0	0	1	0	0
CHAF1B	8208	broad.mit.edu	37	21	37785504	37785504	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr21:37785504G>A	ENST00000314103.4	+	12	1535	c.1384G>A	c.(1384-1386)Ggg>Agg	p.G462R		NM_005441.2	NP_005432.1	Q13112	CAF1B_HUMAN	chromatin assembly factor 1, subunit B (p60)	462					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(2)	20						CCCCTTGCCGGGGCCTTCGGA	0.627000													4	31					0	0	1	0	0
GOLGA6L5	0	broad.mit.edu	37	15	85053124	85053124	+	RNA	SNP	G	G	T			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr15:85053124G>T	ENST00000414190.2	-	0	328					NR_003246.2																						TAAATGTTTTGTTTTTTTTTT	0.353000													3	7					0.115264	0.115264	1	1	0
TLR8	51311	broad.mit.edu	37	X	12940129	12940129	+	Missense_Mutation	SNP	G	G	C			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chrX:12940129G>C	ENST00000218032.6	+	2	3057	c.2970G>C	c.(2968-2970)ttG>ttC	p.L990F	TLR8_ENST00000311912.5_Missense_Mutation_p.L1008F	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	990	TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CTCAGTATTTGAGGCTACGGC	0.463000													6	113					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137801382	137801382	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr7:137801382G>A	ENST00000242375.3	+	9	997	c.955G>A	c.(955-957)Gaa>Aaa	p.E319K	AKR1D1_ENST00000468877.2_3'UTR|AKR1D1_ENST00000411726.2_Missense_Mutation_p.E278K|AKR1D1_ENST00000432161.1_Silent_p.*291*	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	319					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						CGATCATCCTGAATACCCATT	0.443000													6	65					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	406992	406992	+	Silent	SNP	C	C	T			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr9:406992C>T	ENST00000432829.2	+	28	3565	c.3249C>T	c.(3247-3249)tcC>tcT	p.S1083S	DOCK8_ENST00000382329.1_Silent_p.S618S|DOCK8_ENST00000469391.1_Silent_p.S1051S|DOCK8_ENST00000453981.1_Silent_p.S1151S	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1151					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ATCTGACTTCCGAGTACCGCC	0.527000													7	120					0	0	1	0	0
NDUFA9	4704	broad.mit.edu	37	12	4771757	4771757	+	Missense_Mutation	SNP	C	C	T			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr12:4771757C>T	ENST00000266544.5	+	6	631	c.611C>T	c.(610-612)tCg>tTg	p.S204L		NM_005002.4	NP_004993.1	Q16795	NDUA9_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	204					mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21					NADH(DB00157)	GTAAAGCCGTCGGACATCTTT	0.388000													7	127					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70249984	70249984	+	Missense_Mutation	SNP	C	C	T	rs34479874		TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr7:70249984C>T	ENST00000342771.4	+	16	2524	c.2203C>T	c.(2203-2205)Ctc>Ttc	p.L735F	AUTS2_ENST00000406775.2_Missense_Mutation_p.L711F	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	735										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CAGCAACTTCCTCAACCCTGC	0.517000													4	59					0	0	1	0	0
FAM78A	286336	broad.mit.edu	37	9	134136313	134136313	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr9:134136313G>A	ENST00000372271.3	-	2	1115	c.748C>T	c.(748-750)Ccg>Tcg	p.P250S	FAM78A_ENST00000372269.3_Missense_Mutation_p.P247S|FAM78A_ENST00000247295.4_5'UTR	NM_033387.3	NP_203745.2	Q5JUQ0	FA78A_HUMAN	family with sequence similarity 78, member A	250										NS(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		GCGCTGGGCGGGATGGGCTCA	0.687000													6	116					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	93798	93798	+	Silent	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr10:93798G>A	ENST00000447903.2	-	4	633	c.318C>T	c.(316-318)acC>acT	p.T106T	TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000309812.4_Silent_p.T178T|TUBB8_ENST00000332708.5_3'UTR			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	178					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GCTCCACCACGGTGTCCGACA	0.522000													16	113					0	0	1	0	0
RLIM	51132	broad.mit.edu	37	X	73812337	73812337	+	Missense_Mutation	SNP	C	C	G			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chrX:73812337C>G	ENST00000332687.6	-	4	1031	c.813G>C	c.(811-813)ttG>ttC	p.L271F	RLIM_ENST00000349225.2_Missense_Mutation_p.L271F	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	271					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTTGCTGCCTCAATGTCACAT	0.453000													8	117					0	0	1	0	0
AC093838.4	0	broad.mit.edu	37	2	132258593	132258593	+	RNA	SNP	A	A	G	rs13415770	by1000genomes	TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr2:132258593A>G	ENST00000438378.2	+	0	777					NR_026922.1																						CTGTACCACAACAAGGTCCAG	0.617000													3	23					0	0	1	0	0
FAM98C	147965	broad.mit.edu	37	19	38896057	38896057	+	Missense_Mutation	SNP	G	G	C			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr19:38896057G>C	ENST00000252530.5	+	5	648	c.629G>C	c.(628-630)aGa>aCa	p.R210T	FAM98C_ENST00000588262.1_Intron|FAM98C_ENST00000343358.7_Intron	NM_174905.3	NP_777565.3	Q17RN3	FA98C_HUMAN	family with sequence similarity 98, member C	210										endometrium(2)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GATGCACCCAGATGGGTAAGA	0.572000													4	57					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197298099	197298099	+	Missense_Mutation	SNP	G	G	A			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr2:197298099G>A	ENST00000260983.2	-	2	231	c.49C>T	c.(49-51)Ccc>Tcc	p.P17S		NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	17					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						CGCATCTGGGGATTTCGACGC	0.577000													5	69					0	0	1	0	0
B3GNT8	374907	broad.mit.edu	37	19	41931682	41931682	+	Silent	SNP	G	G	A	rs142140890		TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr19:41931682G>A	ENST00000321702.2	-	3	1455	c.1002C>T	c.(1000-1002)gaC>gaT	p.D334D	CTC-435M10.6_ENST00000598887.1_RNA	NM_198540.2	NP_940942.1	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	334					poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity			cervix(1)|kidney(2)|large_intestine(1)|lung(5)|prostate(2)	11						CAGTGTAGACGTCCTCAAAGG	0.692000													4	53					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160087145	160087145	+	Missense_Mutation	SNP	G	G	C			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr2:160087145G>C	ENST00000263635.6	+	27	5445	c.5208G>C	c.(5206-5208)caG>caC	p.Q1736H	TANC1_ENST00000454300.1_Missense_Mutation_p.Q1630H	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	1736						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						TCCAACAGCAGAGCAATCCTC	0.577000													8	109					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				24	68					0	0	1	0	0
NSUN5P1	0	broad.mit.edu	37	7	75044463	75044463	+	RNA	SNP	G	G	A	rs71245954		TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr7:75044463G>A	ENST00000393633.2	+	0	3631																				large_intestine(1)|lung(1)	2						TGCCTGTGCCGCCCCAGGCAA	0.612000													3	32					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	732475	732477	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr9:732475_732477delGAG	ENST00000382303.1	+	10	3755_3757	c.3103_3105delGAG	c.(3103-3105)del	p.E1039del	KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382297.2_In_Frame_Del_p.E1039del|KANK1_ENST00000382293.3_In_Frame_Del_p.E881del	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	1039					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TCTTGAAGAAGAGGAGGAGGAGG	0.463													7	148	---	---	---	---					
CDK12	51755	broad.mit.edu	37	17	37686861	37686863	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	cbc0921a-26ee-4492-af40-ba86d2868ef0	g.chr17:37686861_37686863delTCC	ENST00000447079.4	+	14	3798_3800	c.3765_3767delTCC	c.(3763-3768)tgt>tg	p.CP1255del	CDK12_ENST00000430627.2_Intron	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	1255					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						CCACAGCATGTCCTCCTCACATT	0.498			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			9	330	---	---	---	---					
CDK12	51755	broad.mit.edu	37	17	37686861	37686863	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-E8-A2JQ-01A-11D-A19J-08	TCGA-E8-A2JQ-11A-11D-A19J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52299cf0-654e-4a0a-aa9d-dea3c5f1485c	1e2e5415-3eb0-4279-a6cd-aac232c67b8a	g.chr17:37686861_37686863delTCC	ENST00000447079.4	+	14	3798_3800	c.3765_3767delTCC	c.(3763-3768)tgt>tg	p.CP1255del	CDK12_ENST00000430627.2_Intron	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	1255					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						CCACAGCATGTCCTCCTCACATT	0.498			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			9	330	---	---	---	---					
