Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC3A1	6519	broad.mit.edu	37	2	44527120	44527120	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr2:44527120G>A	ENST00000260649.6	+	5	978	c.902G>A	c.(901-903)cGg>cAg	p.R301Q	SLC3A1_ENST00000409387.1_Missense_Mutation_p.R301Q|SLC3A1_ENST00000409229.3_Missense_Mutation_p.R301Q|SLC3A1_ENST00000410056.3_Missense_Mutation_p.R301Q|SLC3A1_ENST00000409741.1_Missense_Mutation_p.R301Q|SLC3A1_ENST00000409380.1_Missense_Mutation_p.R23Q	NM_000341.3	NP_000332.2	Q07837	SLC31_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 1	301					carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(3)	26		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	GAAATTTTACGGTTCTGGCTC	0.363000													24	104					0	0	0.003954	0	0
FETUB	26998	broad.mit.edu	37	3	186370224	186370224	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr3:186370224A>G	ENST00000265029.3	+	7	1054	c.953A>G	c.(952-954)aAg>aGg	p.K318R	FETUB_ENST00000382136.3_Missense_Mutation_p.K281R|RP11-134F2.2_ENST00000455926.1_RNA|FETUB_ENST00000539949.1_Missense_Mutation_p.K170R|FETUB_ENST00000450521.1_Missense_Mutation_p.K318R|FETUB_ENST00000382134.3_Missense_Mutation_p.K253R|RP11-134F2.2_ENST00000428501.1_RNA	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	318						extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		TCCCAGGAAAAGGGCCCTCAG	0.527000													3	194					0	0	0.004672	0	0
SDHAP1	0	broad.mit.edu	37	3	195701327	195701327	+	RNA	SNP	T	T	C	rs148798763	by1000genomes	TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr3:195701327T>C	ENST00000427841.1	-	0	1497					NR_003264.2																						CCAGGTCCAATAGCGAGTTTG	0.597000													3	130					0	0	0.004672	0	0
SLC39A14	23516	broad.mit.edu	37	8	22275185	22275185	+	Missense_Mutation	SNP	A	A	T			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr8:22275185A>T	ENST00000381237.1	+	8	1288	c.1169A>T	c.(1168-1170)aAc>aTc	p.N390I	SLC39A14_ENST00000240095.6_Missense_Mutation_p.N390I|SLC39A14_ENST00000289952.5_Missense_Mutation_p.N390I|SLC39A14_ENST00000359741.5_Missense_Mutation_p.N390I	NM_001128431.2	NP_001121903.1	Q15043	S39AE_HUMAN	solute carrier family 39 (zinc transporter), member 14	390						endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity			NS(1)|endometrium(4)|large_intestine(2)|lung(4)|prostate(1)	12				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)		ATCCTGCTCAACGCTGGGATG	0.547000													61	84					0	0	0.003610	0	0
GPR124	25960	broad.mit.edu	37	8	37698636	37698636	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr8:37698636C>T	ENST00000315215.7	+	16	2492	c.2129C>T	c.(2128-2130)gCc>gTc	p.A710V	GPR124_ENST00000412232.2_Missense_Mutation_p.A927V			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	927	GPS.				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			AGCCTTGGCGCCTTCTACATC	0.627000													5	186					0	0	0.001984	0	0
METTL17	64745	broad.mit.edu	37	14	21465001	21465001	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr14:21465001T>C	ENST00000382985.4	+	13	1419	c.1396T>C	c.(1396-1398)Tcc>Ccc	p.S466P	METTL17_ENST00000339374.6_Silent_p.T441T|RP11-84C10.4_ENST00000557335.1_RNA|METTL17_ENST00000556670.2_Silent_p.T432T			Q9H7H0	MET17_HUMAN	methyltransferase like 17	0					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20						CTGTGCTTACTCCGTCTGCGT	0.527000													3	110					0	0	0.000602	0	0
PRB2	653247	broad.mit.edu	37	12	11546180	11546180	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr12:11546180G>C	ENST00000389362.4	-	3	867	c.832C>G	c.(832-834)Cca>Gca	p.P278A	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CCTGGAGGTGGGGGACCTTGA	0.617000													84	201					0	0	0.003610	0	0
CEACAM5	1048	broad.mit.edu	37	19	42224846	42224846	+	Silent	SNP	G	G	A			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr19:42224846G>A	ENST00000221992.6	+	8	1890	c.1776G>A	c.(1774-1776)ggG>ggA	p.G592G	CEACAM5_ENST00000398599.4_Silent_p.G591G|CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000405816.1_Silent_p.G592G	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	592	Ig-like 6.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TTCCAGATGGGCCGGACACCC	0.557000													98	147					0	0	0.003610	0	0
ANKS1A	23294	broad.mit.edu	37	6	34985340	34985340	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr6:34985340G>A	ENST00000360359.3	+	11	1652	c.1514G>A	c.(1513-1515)gGc>gAc	p.G505D	ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	505						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						CTCCTCCACGGCTCCTCCCCG	0.701000													18	38					0	0	0.006122	0	0
LAMC1	3915	broad.mit.edu	37	1	183087214	183087214	+	Silent	SNP	T	T	C			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr1:183087214T>C	ENST00000258341.4	+	11	2180	c.1923T>C	c.(1921-1923)ccT>ccC	p.P641P		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	641	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent	p.P641P(1)		NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCTTACCCCTTTTGAATTTC	0.418000													3	101					0	0	0.004672	0	0
MT-ATP6	4508	broad.mit.edu	37	MT	9047	9047	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chrM:9047T>C	ENST00000361899.2	+	1	521	c.521T>C	c.(520-522)aTt>aCt	p.I174T						mitochondrially encoded ATP synthase 6											breast(2)|endometrium(7)|kidney(8)|prostate(1)	18						CATGCACCTAATTGGAAGCGC	0.448000													46	1					0	0	0.003610	0	0
UBA6	55236	broad.mit.edu	37	4	68500218	68500218	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr4:68500218C>G	ENST00000322244.4	-	21	1920	c.1861G>C	c.(1861-1863)Gaa>Caa	p.E621Q		NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6	621					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						AATGGTATTTCCTCTTCTGGG	0.328000													7	47					0	0	0.001984	0	0
MAP7D2	256714	broad.mit.edu	37	X	20029036	20029036	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chrX:20029036G>A	ENST00000379651.3	-	15	2102	c.2084C>T	c.(2083-2085)cCc>cTc	p.P695L	MAP7D2_ENST00000452324.3_Missense_Mutation_p.P643L|MAP7D2_ENST00000443379.3_Missense_Mutation_p.P650L|MAP7D2_ENST00000379643.5_Missense_Mutation_p.P736L|MAP7D2_ENST00000543767.1_Missense_Mutation_p.P580L	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	695										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						GAATGTCGGGGGACCAGTGAA	0.463000													53	84					0	0	0.003610	0	0
URI1	8725	broad.mit.edu	37	19	30477203	30477203	+	Silent	SNP	T	T	C			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr19:30477203T>C	ENST00000392271.1	+	4	543	c.18T>C	c.(16-18)ccT>ccC	p.P6P	URI1_ENST00000312051.6_Silent_p.P42P|URI1_ENST00000360605.4_Silent_p.P64P|URI1_ENST00000542441.2_Silent_p.P82P	NM_003796.3	NP_003787.2	O94763	RMP_HUMAN	URI1, prefoldin-like chaperone	82					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding	p.P82P(1)									CATTTGGCCCTTTTGCCTTCA	0.363000													3	96					0	0	0.004672	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				30	44					0	0	0.002096	0	0
POMC	5443	broad.mit.edu	37	2	25384456	25384457	+	In_Frame_Ins	INS	-	-	GCCGCTGCT	rs10654394	byFrequency	TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr2:25384456_25384457insGCCGCTGCT	ENST00000405623.1	-	3	752_753	c.297_298insAGCAGCGGC	c.(295-300)ggcagg>ggAGCAGCGGCcagg	p.99_100GR>GAAAR	POMC_ENST00000395826.2_In_Frame_Ins_p.99_100GR>GAAAR|POMC_ENST00000264708.3_In_Frame_Ins_p.99_100GR>GAAAR|POMC_ENST00000380794.1_In_Frame_Ins_p.99_100GR>GAAAR			P01189	COLI_HUMAN	proopiomelanocortin	99			Missing.		cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	TTCTGCCCTGCgccgctgctgc	0.728													6	9	---	---	---	---					
AC074391.1	0	broad.mit.edu	37	2	65738847	65738847	+	RNA	DEL	T	T	-	rs111377658		TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr2:65738847delT	ENST00000377977.3	+	0	862																											ttttTTGAAATTTTTTTTTTT	0.294													2	4	---	---	---	---					
PHACTR2	9749	broad.mit.edu	37	6	144081695	144081696	+	Frame_Shift_Ins	INS	-	-	A			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr6:144081695_144081696insA	ENST00000427704.2	+	5	709_710	c.579_580insA	c.(577-582)ataaaafs	p.IK193fs	PHACTR2_ENST00000367584.4_Intron|PHACTR2_ENST00000440869.2_Frame_Shift_Ins_p.IK204fs|PHACTR2_ENST00000367582.3_Intron|PHACTR2_ENST00000305766.6_Intron	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	193							actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TGCCTCCCATTAAAAAAAATAC	0.569													7	102	---	---	---	---					
ZNF658	26149	broad.mit.edu	37	9	40789482	40789483	+	Splice_Site	INS	-	-	A			TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr9:40789482_40789483insA	ENST00000602553.1	-	2	94		c.e2-2		ZNF658_ENST00000441795.1_Splice_Site|ZNF658_ENST00000377626.3_Intron			Q5TYW1	ZN658_HUMAN	zinc finger protein 658						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTCATGTGCCTAAAAAAAAAAA	0.426													4	8	---	---	---	---					
TPTE2P6	0	broad.mit.edu	37	13	25157747	25157748	+	RNA	INS	-	-	T	rs144668552	by1000genomes	TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr13:25157747_25157748insT	ENST00000453498.1	+	0	554																											AAAATGGGAGGTTTTTTTAGGG	0.411													4	9	---	---	---	---					
PNMAL2	57469	broad.mit.edu	37	19	46997016	46997017	+	In_Frame_Ins	INS	-	-	CGGCCT	rs147338403	by1000genomes	TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr19:46997016_46997017insCGGCCT	ENST00000599531.1	-	1	2738_2739	c.1706_1707insAGGCCG	c.(1705-1707)cgg>cAGGCCGgg	p.569_569R>QAG	PNMAL2_ENST00000594749.1_Intron|PNMAL2_ENST00000377655.2_Intron	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	571										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		GAGTGACGCCCCGGCCTCGGCC	0.777													3	5	---	---	---	---					
RNF215	200312	broad.mit.edu	37	22	30782087	30782089	+	In_Frame_Del	DEL	AGA	AGA	-	rs5997629	byFrequency	TCGA-EL-A3GX-01A-11D-A202-08	TCGA-EL-A3GX-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e97b18a0-36d2-43ab-88cf-0e188dbf0cac	cc166057-aced-4aaf-80ad-22f9d0414d10	g.chr22:30782087_30782089delAGA	ENST00000382363.3	-	3	545_547	c.471_473delTCT	c.(469-474)ctc>ct	p.LL157del		NM_001017981.1	NP_001017981.1	Q9Y6U7	RN215_HUMAN	ring finger protein 215	157						integral to membrane	zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)	6						GTTCAGGATGAGAAGAAGCAGGG	0.606													10	12	---	---	---	---					
