Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TEX30	93081	broad.mit.edu	37	13	103419661	103419661	+	Silent	SNP	G	G	A			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr13:103419661G>A	ENST00000376019.1	-	3	1179	c.343C>T	c.(343-345)Ctg>Ttg	p.L115L	TEX30_ENST00000376021.4_Silent_p.L115L|TEX30_ENST00000376027.1_Intron|TEX30_ENST00000376032.4_Silent_p.L156L|TEX30_ENST00000376029.3_Intron|TEX30_ENST00000376022.1_Intron			Q5JUR7	CM027_HUMAN	testis expressed 30	156										lung(1)|urinary_tract(1)	2						GACACAAACAGTACAGGCTCT	0.403000													3	88					0	0	0.184627	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11907	11907	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chrM:11907T>C	ENST00000361381.2	+	1	1148	c.1148T>C	c.(1147-1149)gTa>gCa	p.383_383insA						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						CTCTGTGCTAGTAACCACGTT	0.443000													12	2					0	0	0.520397	0	0
NACA	4666	broad.mit.edu	37	12	57111912	57111912	+	Silent	SNP	G	G	A	rs2926744		TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr12:57111912G>A	ENST00000454682.1	-	3	3683	c.3402C>T	c.(3400-3402)ccC>ccT	p.P1134P	NACA_ENST00000550952.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000551793.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CTTTTGGGGAGGGAGGAGTTG	0.642000			T	BCL6	NHL								6	70					0	0	0.248553	0	0
TM9SF4	9777	broad.mit.edu	37	20	30753110	30753110	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr20:30753110G>A	ENST00000217315.5	+	18	2081	c.1741G>A	c.(1741-1743)Gag>Aag	p.E581K	TM9SF4_ENST00000398022.2_Missense_Mutation_p.E598K			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	598						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGACATCGTGGAGTTCATCCC	0.562000													30	191					0	0	0.827153	0	0
DMPK	1760	broad.mit.edu	37	19	46278224	46278224	+	Silent	SNP	G	G	A	rs138445739		TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr19:46278224G>A	ENST00000600757.1	-	8	1917	c.1230C>T	c.(1228-1230)taC>taT	p.Y410Y	DMPK_ENST00000458663.2_Silent_p.Y400Y|DMPK_ENST00000447742.2_Silent_p.Y400Y|DMPK_ENST00000343373.4_Silent_p.Y415Y|DMPK_ENST00000354227.5_Silent_p.Y400Y|DMPK_ENST00000595361.1_5'UTR|DMPK_ENST00000291270.4_Silent_p.Y405Y			Q09013	DMPK_HUMAN	dystrophia myotonica-protein kinase	415	AGC-kinase C-terminal.				regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(5)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)|urinary_tract(2)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		CCATGCAGGAGTAGGAGTAGC	0.617000													3	70					0	0	0.150653	0	0
FAM126B	285172	broad.mit.edu	37	2	201853010	201853010	+	Silent	SNP	G	G	T			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr2:201853010G>T	ENST00000418596.2	-	11	1153	c.966C>A	c.(964-966)atC>atA	p.I322I	AC005037.3_ENST00000413848.1_RNA	NM_173822.3	NP_776183.1	Q8IXS8	F126B_HUMAN	family with sequence similarity 126, member B	322						intracellular				endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16						TATGACGACGGATTGAAGCTG	0.428000													4	182					0.150653	0.162469	0.150653	1	0
ZNF208	7757	broad.mit.edu	37	19	22155282	22155282	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr19:22155282T>C	ENST00000397126.4	-	4	2702	c.2554A>G	c.(2554-2556)Aag>Gag	p.K852E	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAATTACCTTATGTTTAGTA	0.373000													3	65					0	0	0.248553	0	0
TTLL5	23093	broad.mit.edu	37	14	76259282	76259282	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr14:76259282C>T	ENST00000298832.9	+	27	3215	c.3010C>T	c.(3010-3012)Cat>Tat	p.H1004Y	TTLL5_ENST00000557636.1_Missense_Mutation_p.H1019Y|TTLL5_ENST00000556893.1_Missense_Mutation_p.H555Y|TTLL5_ENST00000554510.1_Missense_Mutation_p.H513Y	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1004					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		AAACAAGCATCATTCAGGAAT	0.378000													12	37					0	0	0.457914	0	0
RP11-1166P10.6	0	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													3	86					0	0	0.115264	0	0
PEX10	5192	broad.mit.edu	37	1	2341873	2341873	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr1:2341873C>G	ENST00000288774.3	-	2	157	c.130G>C	c.(130-132)Gag>Cag	p.E44Q	PEX10_ENST00000447513.2_Missense_Mutation_p.E44Q|PEX10_ENST00000507596.1_Missense_Mutation_p.E44Q	NM_153818.1	NP_722540.1	O60683	PEX10_HUMAN	peroxisomal biogenesis factor 10	44					protein import into peroxisome matrix	integral to peroxisomal membrane|peroxisomal membrane	protein binding|protein C-terminus binding|zinc ion binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(2)	7	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.1e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.02e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00102)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0169)|Lung(427;0.199)		TTCCTCCACTCCAGCCACTTC	0.592000													4	72					0	0	0.278610	0	0
RRN3P2	0	broad.mit.edu	37	16	29110438	29110438	+	RNA	SNP	T	T	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr16:29110438T>C	ENST00000564580.1	+	0	1111																		p.L368P(6)									TTGCAGTATCTTCAGAGTCTG	0.328000													3	78					0	0	0.115264	0	0
MUC5B	727897	broad.mit.edu	37	11	1281040	1281040	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr11:1281040G>A	ENST00000447027.1	+	45	16835	c.16777G>A	c.(16777-16779)Gcc>Acc	p.A5593T	MUC5B_ENST00000529681.1_Missense_Mutation_p.A5590T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	5590					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGTCCAGACCGCCTGCCTCAC	0.657000													10	119					0	0	0.411799	0	0
FAM120C	54954	broad.mit.edu	37	X	54209023	54209023	+	Missense_Mutation	SNP	G	G	T	rs144201658		TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chrX:54209023G>T	ENST00000375180.2	-	1	665	c.609C>A	c.(607-609)aaC>aaA	p.N203K	FAM120C_ENST00000477084.1_Missense_Mutation_p.N203K|FAM120C_ENST00000497680.1_5'UTR|FAM120C_ENST00000328235.4_Missense_Mutation_p.N203K	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	203										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GGGTGCCCTTGTTGCCCACGT	0.706000													20	39					7.41877e-09	8.87027e-09	0.608945	1	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				27	52					0	0	0.760397	0	0
ADCY8	114	broad.mit.edu	37	8	132002665	132002665	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr8:132002665G>A	ENST00000286355.5	-	2	3176	c.1084C>T	c.(1084-1086)Cgc>Tgc	p.R362C	ADCY8_ENST00000377928.3_Missense_Mutation_p.R362C	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	362					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding	p.R362S(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GTCTCCAGGCGCAGCCTGGCC	0.502000										HNSCC(32;0.087)			4	159					0	0	0.184627	0	0
ZNF57	126295	broad.mit.edu	37	19	2917961	2917961	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr19:2917961C>T	ENST00000306908.5	+	4	1490	c.1342C>T	c.(1342-1344)Cat>Tat	p.H448Y	AC006277.2_ENST00000520090.2_RNA|ZNF57_ENST00000523428.1_Missense_Mutation_p.H416Y	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGCAGCTCCATAAATGTGA	0.443000													4	85					0	0	0.217242	0	0
GPT	2875	broad.mit.edu	37	8	145732033	145732033	+	Silent	SNP	C	C	T			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr8:145732033C>T	ENST00000394955.2	+	9	1504	c.1281C>T	c.(1279-1281)cgC>cgT	p.R427R	GPT_ENST00000528431.1_Silent_p.R427R	NM_005309.2	NP_005300.1	P24298	ALAT1_HUMAN	glutamic-pyruvate transaminase (alanine aminotransferase)	427					gluconeogenesis	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)		L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CGGTGGAGCGCGCTCAGGTCA	0.731000													7	9					0	0	0.278610	0	0
BRD3	8019	broad.mit.edu	37	9	136915622	136915622	+	Silent	SNP	G	G	A	rs142203601	byFrequency	TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr9:136915622G>A	ENST00000303407.7	-	5	773	c.588C>T	c.(586-588)atC>atT	p.I196I	BRD3_ENST00000371834.2_Silent_p.I196I|BRD3_ENST00000357885.2_Silent_p.I196I	NM_007371.3	NP_031397.1	Q15059	BRD3_HUMAN	bromodomain containing 3	196						nucleus	protein binding		BRD3/C15orf55(3)	kidney(1)|skin(1)|stomach(4)	6				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		GGGTGGCAGCGATGACGGGCG	0.662000			T	C15orf55	lethal midline carcinoma of young people								15	214					0	0	0.592651	0	0
IFNAR2	3455	broad.mit.edu	37	21	34635187	34635187	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr21:34635187G>C	ENST00000342136.4	+	9	1256	c.930G>C	c.(928-930)aaG>aaC	p.K310N	AP000295.9_ENST00000433395.2_Intron|IFNAR2_ENST00000382241.3_Missense_Mutation_p.K310N|IFNAR2_ENST00000342101.3_3'UTR|IFNAR2_ENST00000404220.3_3'UTR			P48551	INAR2_HUMAN	interferon (alpha, beta and omega) receptor 2	310					JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	11					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	TCAACAGAAAGAAGAAAGTGT	0.428000													18	127					0	0	0.639603	0	0
INPP5F	22876	broad.mit.edu	37	10	121586462	121586462	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr10:121586462T>C	ENST00000361976.2	+	20	2735	c.2569T>C	c.(2569-2571)Tca>Cca	p.S857P	INPP5F_ENST00000369080.3_Missense_Mutation_p.S247P	NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	857							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		AGATAATGACTCATACCACTC	0.408000													47	78					0	0	0.870114	0	0
RRN3P3	0	broad.mit.edu	37	16	22448598	22448598	+	RNA	SNP	T	T	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr16:22448598T>C	ENST00000551766.1	-	0	438					NR_027460.1																						gcctcctccttctcctccttc	0.751000													2	4					0	0	0.115264	0	0
RNF216	54476	broad.mit.edu	37	7	5662664	5662664	+	Missense_Mutation	SNP	G	G	T			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr7:5662664G>T	ENST00000425013.2	-	17	2652	c.2428C>A	c.(2428-2430)Cct>Act	p.P810T	RNF216_ENST00000389902.3_Missense_Mutation_p.P867T|RNF216_ENST00000469375.1_5'UTR	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	810	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		CGCACGGGAGGCAGGGGGAAG	0.647000													54	110					4.33383e-22	5.29691e-22	0.870114	1	0
PCDHA8	0	broad.mit.edu	37	5	140222759	140222759	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr5:140222759C>G	ENST00000531613.1	+	1	1853	c.1853C>G	c.(1852-1854)cCt>cGt	p.P618R	PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.P618R	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGCAGCCCTCGCATCCCG	0.677000													8	223					0	0	0.361761	0	0
YY1	7528	broad.mit.edu	37	14	100743846	100743846	+	Missense_Mutation	SNP	G	G	T			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr14:100743846G>T	ENST00000262238.4	+	5	1414	c.1154G>T	c.(1153-1155)tGc>tTc	p.C385F		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	385	Involved in masking transactivation domain.				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding	p.C385F(1)		cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				CCCTATGTGTGCCCCTTCGAT	0.463000													6	83					0.0293803	0.0323184	0.248553	1	0
INTS2	57508	broad.mit.edu	37	17	59989322	59989322	+	Silent	SNP	G	G	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr17:59989322G>C	ENST00000444766.3	-	6	858	c.783C>G	c.(781-783)gcC>gcG	p.A261A	INTS2_ENST00000251334.6_Silent_p.A253A	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	261					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						GGACCTTGAGGGCCTGAGAAG	0.438000													9	120					0	0	0.479597	0	0
KLF6	1316	broad.mit.edu	37	10	3824179	3824179	+	Silent	SNP	G	G	A			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr10:3824179G>A	ENST00000497571.1	-	2	590	c.330C>T	c.(328-330)agC>agT	p.S110S	KLF6_ENST00000542957.1_Silent_p.S110S|KLF6_ENST00000173785.4_5'UTR|KLF6_ENST00000469435.1_Silent_p.S110S	NM_001160124.1|NM_001300.5	NP_001153596.1|NP_001291.3	Q99612	KLF6_HUMAN	Kruppel-like factor 6	110					B cell differentiation	nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				Colorectal(1;0.238)		CAGAGGATTCGCTGCTGACAT	0.517000											OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	298					0	0	0.500413	0	0
SLC15A1	6564	broad.mit.edu	37	13	99354751	99354751	+	Silent	SNP	T	T	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr13:99354751T>C	ENST00000376503.5	-	18	1504	c.1449A>G	c.(1447-1449)aaA>aaG	p.K483K		NM_005073.3	NP_005064.1	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide transporter), member 1	483					digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CATTTTCCCCTTTTTCTGGCT	0.284000													3	118					0	0	0.184627	0	0
PRDM9	56979	broad.mit.edu	37	5	23526999	23526999	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr5:23526999C>G	ENST00000296682.3	+	11	1984	c.1802C>G	c.(1801-1803)aCa>aGa	p.T601R		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	601					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.T601R(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CACCAGAGGACACACACAGGG	0.597000										HNSCC(3;0.000094)			4	169					0	0	0.217242	0	0
RFPL1S	0	broad.mit.edu	37	22	29833529	29833529	+	RNA	SNP	A	A	G			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr22:29833529A>G	ENST00000461286.2	-	0	4847					NR_002727.2																						AACTGGAGATATATCACCAGT	0.348000													3	4					0	0	0.115264	0	0
SETBP1	26040	broad.mit.edu	37	18	42530643	42530643	+	Missense_Mutation	SNP	A	A	T			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr18:42530643A>T	ENST00000282030.5	+	4	1634	c.1338A>T	c.(1336-1338)gaA>gaT	p.E446D		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	446						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TGAGCAGTGAAGTAGTTAACA	0.453000									Schinzel-Giedion syndrome				6	98					0	0	0.248553	0	0
CCDC15	80071	broad.mit.edu	37	11	124857562	124857562	+	Silent	SNP	A	A	G			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr11:124857562A>G	ENST00000529051.1	+	8	1699	c.1440A>G	c.(1438-1440)ttA>ttG	p.L480L	CCDC15_ENST00000344762.5_Silent_p.L480L			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	480						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AGAATTTTTTATCTAGAGACC	0.408000													3	109					0	0	0.184627	0	0
TTN	7273	broad.mit.edu	37	2	179579858	179579858	+	Silent	SNP	G	G	A			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr2:179579858G>A	ENST00000589042.1	-	90	26279	c.26055C>T	c.(26053-26055)agC>agT	p.S8685S	TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Silent_p.S7441S|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Silent_p.S8368S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8368	Ig-like 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTCTTGCCGCTCCTAAGTT	0.443000													8	290					0	0	0.361761	0	0
PRDM10	56980	broad.mit.edu	37	11	129812425	129812425	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr11:129812425G>A	ENST00000358825.5	-	7	1093	c.862C>T	c.(862-864)Cgg>Tgg	p.R288W	PRDM10_ENST00000423662.2_Missense_Mutation_p.R202W|PRDM10_ENST00000526082.1_Missense_Mutation_p.R202W|PRDM10_ENST00000528746.1_Missense_Mutation_p.R262W|PRDM10_ENST00000360871.3_Missense_Mutation_p.R288W|PRDM10_ENST00000304538.6_Missense_Mutation_p.R202W	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	288	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TGGGCTGGCCGTACAAACATC	0.453000													4	120					0	0	0.248553	0	0
ABHD4	63874	broad.mit.edu	37	14	23075393	23075393	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr14:23075393G>C	ENST00000428304.2	+	5	776	c.706G>C	c.(706-708)Gat>Cat	p.D236H	ABHD4_ENST00000544562.1_3'UTR	NM_022060.2	NP_071343.2	Q8TB40	ABHD4_HUMAN	abhydrolase domain containing 4	236					lipid catabolic process		hydrolase activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(3)|prostate(1)	14	all_cancers(95;5.49e-05)			GBM - Glioblastoma multiforme(265;0.0153)		CTTTGAAGATGATACCATATC	0.517000													3	28					0	0	0.150653	0	0
FAM182B	0	broad.mit.edu	37	20	25848614	25848614	+	Translation_Start_Site	SNP	C	C	A	rs144456407	by1000genomes	TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr20:25848614C>A	ENST00000376404.2	-	0	172				FAM182B_ENST00000478164.1_5'UTR																lung(1)	1						ccgggcaggcctgaggctggg	0.667000													3	18					0.00909568	0.0102094	0.150653	1	0
USP10	9100	broad.mit.edu	37	16	84792342	84792342	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr16:84792342C>G	ENST00000219473.7	+	5	1326	c.1213C>G	c.(1213-1215)Cta>Gta	p.L405V	USP10_ENST00000570191.1_Missense_Mutation_p.L409V	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	405					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						GAATGTAACCCTAATCCATAA	0.438000													5	137					0	0	0.278610	0	0
RP11-640M9.2	0	broad.mit.edu	37	1	144598726	144598726	+	RNA	SNP	A	A	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr1:144598726A>C	ENST00000419820.1	+	0	654																											CATTCGGTGCACCAAGAGCAA	0.572000													3	26					0	0	0.150653	0	0
KLHL14	57565	broad.mit.edu	37	18	30349967	30349967	+	Silent	SNP	G	G	A			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr18:30349967G>A	ENST00000359358.4	-	2	1026	c.588C>T	c.(586-588)caC>caT	p.H196H	KLHL14_ENST00000358095.4_Silent_p.H196H|AC012123.1_ENST00000426194.1_Intron	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	196						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						CCTCCAGGCCGTGCAGCGCGG	0.612000													4	158					0	0	0.184627	0	0
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	C	T			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr13:115047559C>T	ENST00000375299.3	+	2	327	c.271C>T	c.(271-273)Ctg>Ttg	p.L91L	UPF3A_ENST00000351487.5_Silent_p.L91L	NM_023011.3	NP_075387.1	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A (yeast)	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding	p.L91L(8)		autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731000													3	19					0	0	0.115264	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212431	26212431	+	Silent	SNP	G	G	T			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chrX:26212431G>T	ENST00000379034.1	+	2	617	c.468G>T	c.(466-468)tcG>tcT	p.S156S		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	156	Ser-rich.							p.S156S(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						CCACTGGCTCGCCTGATGCAG	0.507000													6	98					1.06961e-07	1.25167e-07	0.278610	1	0
HHLA2	11148	broad.mit.edu	37	3	108076828	108076828	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr3:108076828C>G	ENST00000357759.5	+	6	1237	c.823C>G	c.(823-825)Ctg>Gtg	p.L275V	HHLA2_ENST00000467562.1_Missense_Mutation_p.L211V|HHLA2_ENST00000491820.1_Missense_Mutation_p.L275V|HHLA2_ENST00000467761.1_Missense_Mutation_p.L275V|HHLA2_ENST00000489514.2_Missense_Mutation_p.L275V	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	275	Ig-like V-type 2.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						GGCTTACTATCTGAGCTCCTC	0.373000													18	103					0	0	0.608945	0	0
SERPINE3	647174	broad.mit.edu	37	13	51915229	51915229	+	Translation_Start_Site	SNP	T	T	G			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr13:51915229T>G	ENST00000524365.1	+	4	627	c.2T>G	c.(1-3)aTg>aGg	p.M1R	SERPINE3_ENST00000521255.1_Start_Codon_SNP_p.M1R|SERPINE3_ENST00000400389.4_Start_Codon_SNP_p.M1R			A8MV23	SERP3_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3	1					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)	2						CCAGCCTCCATGCCGCCTTTC	0.557000													33	60					0	0	0.847076	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50659212	50659212	+	Silent	SNP	A	A	G	rs141527317		TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr22:50659212A>G	ENST00000439308.2	-	16	4068	c.3576T>C	c.(3574-3576)tcT>tcC	p.S1192S	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000248846.5_Silent_p.S1192S	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1192	9 X 27 AA tandem repeats.				G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGCTGGCATCAGACACGTGTC	0.617000													6	143					0	0	0.278610	0	0
A1CF	29974	broad.mit.edu	37	10	52569681	52569681	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr10:52569681C>T	ENST00000395489.2	-	14	1981	c.1585G>A	c.(1585-1587)Gct>Act	p.A529T	A1CF_ENST00000374001.1_Missense_Mutation_p.A528T|A1CF_ENST00000373993.1_Missense_Mutation_p.A536T|A1CF_ENST00000373997.3_Missense_Mutation_p.A528T|A1CF_ENST00000282641.2_Missense_Mutation_p.A536T|A1CF_ENST00000373995.3_Missense_Mutation_p.A536T|A1CF_ENST00000395495.1_Missense_Mutation_p.A481T|ASAH2B_ENST00000483649.1_Intron	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	536					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						gcagcagcagcagtagcCATG	0.527000													4	105					0	0	0.150653	0	0
NACA	4666	broad.mit.edu	37	12	57111705	57111705	+	Silent	SNP	G	G	A	rs2926746		TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr12:57111705G>A	ENST00000454682.1	-	3	3890	c.3609C>T	c.(3607-3609)ccC>ccT	p.P1203P	NACA_ENST00000550952.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000551793.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CTTTTGGGGAGGGAGGAGTTG	0.642000			T	BCL6	NHL								4	179					0	0	0.278610	0	0
TAS1R2	80834	broad.mit.edu	37	1	19181248	19181248	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr1:19181248G>A	ENST00000375371.3	-	3	737	c.716C>T	c.(715-717)aCg>aTg	p.T239M	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	239					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TGTGGGCAGCGTCTCCTGGAA	0.642000													12	15					0	0	0.457914	0	0
RPN1	6184	broad.mit.edu	37	3	128356853	128356853	+	Missense_Mutation	SNP	G	G	T	rs141345041		TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr3:128356853G>T	ENST00000296255.3	-	3	470	c.422C>A	c.(421-423)cCg>cAg	p.P141Q	RPN1_ENST00000497289.1_5'UTR	NM_002950.3	NP_002941.1	P04843	RPN1_HUMAN	ribophorin I	141					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|melanosome|oligosaccharyltransferase complex|rough microsome	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|stomach(2)	13				GBM - Glioblastoma multiforme(114;0.189)		GGTTGGATACGGATGAAGCAC	0.468000			T	EVI1	AML								3	64					0.00909568	0.0102094	0.150653	1	0
ZNF41	7592	broad.mit.edu	37	X	47308077	47308077	+	Silent	SNP	A	A	G			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chrX:47308077A>G	ENST00000377065.4	-	5	1731	c.1092T>C	c.(1090-1092)ttT>ttC	p.F364F	ZNF41_ENST00000397050.2_Silent_p.F374F|ZNF41_ENST00000313116.7_Silent_p.F364F	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	406						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				ATCTCTGGAAAAAGGCTTTTC	0.403000													23	44					0	0	0.681144	0	0
BCL9	607	broad.mit.edu	37	1	147091501	147091501	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr1:147091501delC	ENST00000234739.3	+	8	2280	c.1540delC	c.(1540-1542)ccfs	p.P517fs		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	517	Poly-Pro.|Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					GGTCCGAGGACCCCCCCCTCC	0.582			T	"""IGH@, IGL@"""	B-ALL								10	227	---	---	---	---					
FAM217A	222826	broad.mit.edu	37	6	4069208	4069211	+	Frame_Shift_Del	DEL	TGAA	TGAA	-			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr6:4069208_4069211delTGAA	ENST00000274673.3	-	7	1649_1652	c.1246_1249delTTCA	c.(1246-1251)aafs	p.FK416fs	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	416																	ATAGTAGGTTTGAATGAGAGTTCT	0.387													39	132	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100377342	100377342	+	RNA	DEL	C	C	-			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr7:100377342delC	ENST00000542585.1	+	0	6737				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GGGGCTCAAGCCCCCACTCTG	0.627													2	4	---	---	---	---					
FAM66B	0	broad.mit.edu	37	8	7196263	7196264	+	RNA	DEL	AC	AC	-			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr8:7196263_7196264delAC	ENST00000606573.1	-	0	703																											ACTGAGGGGTacacacacacac	0.500													4	7	---	---	---	---					
ERMP1	79956	broad.mit.edu	37	9	5832860	5832861	+	Frame_Shift_Ins	INS	-	-	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr9:5832860_5832861insC	ENST00000339450.5	-	1	256_257	c.167_168insG	c.(166-168)gagfs	p.E56fs		NM_024896.2	NP_079172.2	Q7Z2K6	ERMP1_HUMAN	endoplasmic reticulum metallopeptidase 1	56					proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			endometrium(2)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|skin(1)	20		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		CGCCGCCGCTACCCCCGGGGCT	0.787													2	4	---	---	---	---					
MARK2	2011	broad.mit.edu	37	11	63606995	63606995	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr11:63606995delC	ENST00000402010.2	+	1	596	c.17delC	c.(16-18)acfs	p.T6fs	MARK2_ENST00000315032.8_Frame_Shift_Del_p.T6fs|MARK2_ENST00000350490.7_Frame_Shift_Del_p.T6fs|MARK2_ENST00000377809.4_Frame_Shift_Del_p.T6fs|MARK2_ENST00000413835.2_Frame_Shift_Del_p.T6fs|MARK2_ENST00000377810.3_5'UTR|MARK2_ENST00000502399.3_Frame_Shift_Del_p.T6fs|MARK2_ENST00000361128.5_Frame_Shift_Del_p.T6fs|MARK2_ENST00000508192.1_Frame_Shift_Del_p.T6fs	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	6					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						AGCGCTCGGACCCCCCTACCC	0.692													2	4	---	---	---	---					
WBP7	0	broad.mit.edu	37	19	36212112	36212113	+	Frame_Shift_Ins	INS	-	-	C			TCGA-EL-A3H7-01A-11D-A21A-08	TCGA-EL-A3H7-11A-11D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	508c8615-e53f-450b-9974-468904b63294	a54892b4-76e9-462a-a1c1-2495c9d2f8c9	g.chr19:36212112_36212113insC	ENST00000222270.7	+	3	1863_1864	c.1863_1864insC	c.(1861-1866)ccccccfs	p.PP621fs	WBP7_ENST00000341701.1_Intron|WBP7_ENST00000420124.1_Frame_Shift_Ins_p.PP621fs|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					TGccccctcctcccccagcccc	0.673													4	4	---	---	---	---					
