Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF791	163049	broad.mit.edu	37	19	12739914	12739914	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr19:12739914A>G	ENST00000343325.4	+	4	1733	c.1571A>G	c.(1570-1572)tAt>tGt	p.Y524C	ZNF490_ENST00000465656.1_Intron|ZNF791_ENST00000540038.1_Missense_Mutation_p.Y415C|ZNF791_ENST00000446165.1_3'UTR|ZNF791_ENST00000458122.3_Missense_Mutation_p.Y492C	NM_153358.2	NP_699189.2	Q3KP31	ZN791_HUMAN	zinc finger protein 791	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)	19						GAGAAACCCTATAAATGTAAA	0.388000													9	99					0	0	1	0	0
PTPRJ	5795	broad.mit.edu	37	11	48146708	48146708	+	Missense_Mutation	SNP	G	G	C			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr11:48146708G>C	ENST00000418331.2	+	6	1415	c.1063G>C	c.(1063-1065)Gga>Cga	p.G355R	PTPRJ_ENST00000440289.2_Missense_Mutation_p.G355R	NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	355	Fibronectin type-III 3.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TGGCACAGAAGGACAGCCCCA	0.532000													14	79					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100092841	100092841	+	Missense_Mutation	SNP	C	C	G			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr9:100092841C>G	ENST00000375202.2	+	32	3550	c.2198C>G	c.(2197-2199)tCt>tGt	p.S733C	CCDC180_ENST00000529487.1_Missense_Mutation_p.S733C|CCDC180_ENST00000395220.1_3'UTR|CCDC180_ENST00000411667.2_Missense_Mutation_p.S730C|CCDC180_ENST00000357054.1_Missense_Mutation_p.S872C|RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000460482.2_3'UTR					coiled-coil domain containing 180																		AAAGAAGGCTCTATTCAGGGA	0.463000													13	27					0	0	1	0	0
LBH	81606	broad.mit.edu	37	2	30457303	30457303	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr2:30457303A>G	ENST00000395323.3	+	2	267	c.59A>G	c.(58-60)gAg>gGg	p.E20G	LBH_ENST00000407930.2_Missense_Mutation_p.E3G|LBH_ENST00000467242.1_3'UTR|LBH_ENST00000406087.1_Missense_Mutation_p.E20G|LBH_ENST00000404397.1_Missense_Mutation_p.E20G|LBH_ENST00000401506.1_Missense_Mutation_p.E26G	NM_030915.3	NP_112177.2	Q53QV2	LBH_HUMAN	limb bud and heart development	20					multicellular organismal development|transcription, DNA-dependent	cytoplasm|nucleolus				endometrium(2)|large_intestine(1)|lung(2)	5	Acute lymphoblastic leukemia(172;0.155)					AAGATGACTGAGGTGATGATG	0.537000													3	164					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42262982	42262982	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr22:42262982G>A	ENST00000361204.4	+	2	402	c.236G>A	c.(235-237)aGc>aAc	p.S79N		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	79	Gly/Pro/Ser-rich.				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						ggcaggggcagcagcagcGGA	0.602000													3	88					0	0	1	0	0
MMP24	10893	broad.mit.edu	37	20	33839758	33839758	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr20:33839758G>A	ENST00000246186.6	+	3	531	c.446G>A	c.(445-447)cGt>cAt	p.R149H	EDEM2_ENST00000540582.1_Intron|MMP24-AS1_ENST00000456350.1_RNA|MMP24-AS1_ENST00000454184.1_RNA|MMP24-AS1_ENST00000433764.1_RNA|MMP24-AS1_ENST00000438751.1_RNA|MMP24-AS1_ENST00000566203.1_RNA	NM_006690.3	NP_006681.1	Q9Y5R2	MMP24_HUMAN	matrix metallopeptidase 24 (membrane-inserted)	149	Poly-Arg.				proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(3)|large_intestine(1)|lung(2)|prostate(2)|skin(5)	14			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CACTTAAGCCGTAGGCGGAGA	0.547000													4	188					0	0	1	0	0
VTA1	51534	broad.mit.edu	37	6	142468447	142468447	+	Missense_Mutation	SNP	C	C	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr6:142468447C>A	ENST00000367630.4	+	1	81	c.23C>A	c.(22-24)cCc>cAc	p.P8H	VTA1_ENST00000452973.2_5'UTR|VTA1_ENST00000367621.1_5'UTR	NM_016485.3	NP_057569.2	Q9NP79	VTA1_HUMAN	vesicle (multivesicular body) trafficking 1	8	Interaction with CHMP5.|Interaction with IST1.				cellular membrane organization|endosome transport|protein transport	cytosol|endosome membrane	protein binding			endometrium(2)|large_intestine(1)|lung(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;1.34e-05)|GBM - Glioblastoma multiforme(68;0.00182)		GCACCGCTGCCCCCGCTCCCC	0.612000											OREG0017699	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	88					5.9392e-07	6.39606e-07	1	1	0
MAPK8IP2	23542	broad.mit.edu	37	22	51044095	51044095	+	Silent	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr22:51044095G>A	ENST00000399908.2	+	5	1865	c.1149G>A	c.(1147-1149)acG>acA	p.T383T	MAPK8IP2_ENST00000329492.3_Silent_p.T648T|MAPK8IP2_ENST00000008876.5_Silent_p.T354T|MAPK8IP2_ENST00000341339.4_Silent_p.T269T|MAPK8IP2_ENST00000399912.1_Silent_p.T383T|MAPK8IP2_ENST00000442429.2_Silent_p.T371T	NM_016431.3	NP_057515.1	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting protein 2	649					behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ACATGCGCACGGGGGAGCGCG	0.652000													3	58					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38536445	38536445	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr21:38536445G>A	ENST00000399017.2	+	32	6010	c.3263G>A	c.(3262-3264)aGt>aAt	p.S1088N	TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000354749.2_Missense_Mutation_p.S1088N|TTC3_ENST00000355666.1_Missense_Mutation_p.S1088N	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1088					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				GACCAACACAGTAACGAATAT	0.398000													3	93					0	0	1	0	0
KIF25	0	broad.mit.edu	37	6	168430272	168430272	+	Missense_Mutation	SNP	T	T	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr6:168430272T>A	ENST00000443060.2	+	3	398	c.7T>A	c.(7-9)Tgg>Agg	p.W3R	KIF25_ENST00000354419.2_Missense_Mutation_p.W3R|KIF25_ENST00000351261.3_Missense_Mutation_p.W3R			Q9UIL4	KIF25_HUMAN	kinesin family member 25	3	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity	p.W3R(1)		NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CCAGATGACATGGACCTCAGG	0.612000													4	221					0	0	1	0	0
TMEM38A	79041	broad.mit.edu	37	19	16799119	16799119	+	Silent	SNP	C	C	T			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr19:16799119C>T	ENST00000187762.2	+	6	928	c.837C>T	c.(835-837)ccC>ccT	p.P279P		NM_024074.1	NP_076979.1	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	279						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)	15						CGGCCATGCCCGCCAAGTCCA	0.657000													25	75					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76751728	76751728	+	Silent	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr6:76751728G>A	ENST00000369950.3	-	2	372	c.183C>T	c.(181-183)ttC>ttT	p.F61F	IMPG1_ENST00000369963.3_Intron	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	61					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity	p.F61F(1)|p.F61L(1)		breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTGCCAAATCGAATATTCGTC	0.368000													20	134					0	0	1	0	0
C12orf44	60673	broad.mit.edu	37	12	52470924	52470924	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr12:52470924T>C	ENST00000336854.4	+	4	1085	c.607T>C	c.(607-609)Tca>Cca	p.S203P	RP11-1100L3.7_ENST00000550301.1_RNA	NM_001098673.1|NM_021934.4	NP_001092143.1|NP_068753.2	Q9BSB4	ATGA1_HUMAN	chromosome 12 open reading frame 44	203					autophagic vacuole assembly	pre-autophagosomal structure	identical protein binding|protein complex binding			endometrium(1)|lung(2)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(357;0.0978)		CCTGGGCACCTCAGTCACCAC	0.577000													3	99					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61951642	61951642	+	Splice_Site	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr20:61951642G>A	ENST00000422202.1	+	24	3164		c.e24-1		COL20A1_ENST00000435874.1_Splice_Site|COL20A1_ENST00000358894.6_Splice_Site|COL20A1_ENST00000326996.6_Splice_Site			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1						cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					CTGCGTTGCAGTTTCAGCTCC	0.701000													3	98					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400848	195400848	+	RNA	SNP	G	G	A	rs7635190	by1000genomes	TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr3:195400848G>A	ENST00000445430.1	+	0	1444																											TCGCAGAGTCGTGCAGGCCTG	0.552000													4	33					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112058796	112058796	+	Silent	SNP	C	C	T			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chrX:112058796C>T	ENST00000371959.3	-	2	1181	c.1182G>A	c.(1180-1182)caG>caA	p.Q394Q	AMOT_ENST00000371962.1_Silent_p.Q162Q|AMOT_ENST00000371958.1_Silent_p.Q162Q|AMOT_ENST00000304758.1_5'UTR|AMOT_ENST00000524145.1_Silent_p.Q394Q	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	394					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity	p.Q394Q(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						gctgctgctgctgttgttggt	0.582000													3	36					0	0	1	0	0
CENPT	80152	broad.mit.edu	37	16	67862707	67862707	+	Silent	SNP	A	A	G			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr16:67862707A>G	ENST00000562787.1	-	14	1868	c.1320T>C	c.(1318-1320)caT>caC	p.H440H	CENPT_ENST00000564817.1_Silent_p.H385H|CENPT_ENST00000219172.3_Silent_p.H440H|CENPT_ENST00000440851.2_Silent_p.H440H	NM_025082.3	NP_079358.3	Q96BT3	CENPT_HUMAN	centromere protein T	440					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding			NS(1)|breast(2)|lung(6)|urinary_tract(1)	10		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		GCCTAGGGGGATGCCTGACCA	0.582000													3	138					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32475708	32475708	+	Nonsense_Mutation	SNP	C	C	A	rs144123569	by1000genomes	TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr2:32475708C>A	ENST00000404025.2	-	5	1713	c.1225G>T	c.(1225-1227)Gaa>Taa	p.E409*	NLRC4_ENST00000402280.1_Nonsense_Mutation_p.E409*|NLRC4_ENST00000360906.5_Nonsense_Mutation_p.E409*|NLRC4_ENST00000342905.6_Intron			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	409	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity	p.E409K(2)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TCCTGCAGTTCGAAATCAAAC	0.473000													3	37					1	1	1	1	0
ZNF335	63925	broad.mit.edu	37	20	44581287	44581287	+	Missense_Mutation	SNP	C	C	T			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr20:44581287C>T	ENST00000322927.2	-	19	2864	c.2764G>A	c.(2764-2766)Ggc>Agc	p.G922S	ZNF335_ENST00000426788.1_Missense_Mutation_p.G767S	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	922					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				TAGTGGGTGCCAGCTTCTTTT	0.587000													53	166					0	0	1	0	0
ZNF878	729747	broad.mit.edu	37	19	12155673	12155673	+	Missense_Mutation	SNP	A	A	C			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr19:12155673A>C	ENST00000602107.1	-	5	683	c.684T>G	c.(682-684)agT>agG	p.S228R	CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591898.1_RNA|CTD-2006C1.2_ENST00000476474.1_RNA|ZNF878_ENST00000547628.1_Missense_Mutation_p.S181R|CTD-2006C1.2_ENST00000591838.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						AACTGGGAAAACTGAATGCTT	0.403000													5	339					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10741777	10741777	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr19:10741777G>A	ENST00000586078.1	+	5	399	c.290G>A	c.(289-291)aGc>aAc	p.S97N	SLC44A2_ENST00000407327.4_Missense_Mutation_p.S95N|SLC44A2_ENST00000335757.5_Missense_Mutation_p.S97N	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	97					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	AAATGTGCCAGCCCCCTGGTT	0.463000													3	134					0	0	1	0	0
IL12RB2	3595	broad.mit.edu	37	1	67833673	67833673	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr1:67833673G>A	ENST00000262345.1	+	10	2064	c.1424G>A	c.(1423-1425)cGg>cAg	p.R475Q	IL12RB2_ENST00000371000.1_Missense_Mutation_p.R475Q|IL12RB2_ENST00000541374.1_Missense_Mutation_p.R475Q|IL12RB2_ENST00000544434.1_Missense_Mutation_p.R475Q	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	475	Fibronectin type-III 4.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						AACTGGCTACGGAGTCGACCC	0.507000													19	103					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161618	90161618	+	RNA	SNP	C	C	T	rs13338202	by1000genomes	TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr16:90161618C>T	ENST00000567960.1	+	0	354				TUBB8P7_ENST00000564451.1_RNA														p.D118D(2)									CAGTGATGGACGTTGTCAGAA	0.607000													3	48					0	0	1	0	0
MAP7D2	256714	broad.mit.edu	37	X	20044031	20044031	+	Silent	SNP	C	C	T			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chrX:20044031C>T	ENST00000379651.3	-	8	942	c.924G>A	c.(922-924)acG>acA	p.T308T	MAP7D2_ENST00000466145.1_5'UTR|MAP7D2_ENST00000452324.3_Silent_p.T256T|MAP7D2_ENST00000443379.3_Silent_p.T263T|MAP7D2_ENST00000379643.5_Silent_p.T349T|MAP7D2_ENST00000543767.1_Silent_p.T193T	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	308										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						AGGGAGGTTTCGTTGTCTTTG	0.493000													37	252					0	0	1	0	0
TMTC4	84899	broad.mit.edu	37	13	101278051	101278051	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr13:101278051G>A	ENST00000342624.5	-	14	1940	c.1682C>T	c.(1681-1683)gCt>gTt	p.A561V	TMTC4_ENST00000328767.5_Missense_Mutation_p.A431V|TMTC4_ENST00000376234.3_Missense_Mutation_p.A542V|TMTC4_ENST00000462211.1_5'UTR	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	542						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TATTTGAACAGCCAAAGACAG	0.368000													4	50					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30602720	30602720	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr10:30602720G>A	ENST00000358107.4	-	10	1956	c.1957C>T	c.(1957-1959)Cgg>Tgg	p.R653W	MTPAP_ENST00000263063.3_Missense_Mutation_p.R523W|MTPAP_ENST00000488290.1_5'UTR			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	523					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						CCCCAGGGCCGATTACTTGAT	0.418000													3	152					0	0	1	0	0
MOG	4340	broad.mit.edu	37	6	29627259	29627259	+	Silent	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr6:29627259G>A	ENST00000376894.4	+	2	370	c.252G>A	c.(250-252)aaG>aaA	p.K84K	MOG_ENST00000469603.1_3'UTR|MOG_ENST00000376898.3_Silent_p.K84K|MOG_ENST00000416766.2_Silent_p.K84K|MOG_ENST00000376891.4_Silent_p.K84K|MOG_ENST00000431798.2_Silent_p.K84K|MOG_ENST00000376888.2_Intron|MOG_ENST00000396704.3_Silent_p.K84K|MOG_ENST00000494692.1_Silent_p.K84K|MOG_ENST00000490427.1_Intron|MOG_ENST00000396701.2_Silent_p.K84K|MOG_ENST00000376917.3_Silent_p.K84K|MOG_ENST00000376902.3_Silent_p.K84K|MOG_ENST00000533330.2_Silent_p.K84K|MOG_ENST00000483013.1_Intron			Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	84	Ig-like V-type.				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						GAAATGGCAAGGACCAAGATG	0.547000													3	139					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76867737	76867737	+	Missense_Mutation	SNP	A	A	G			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr11:76867737A>G	ENST00000409709.3	+	6	774	c.502A>G	c.(502-504)Aca>Gca	p.T168A	MYO7A_ENST00000458637.2_Missense_Mutation_p.T168A|MYO7A_ENST00000409893.1_Missense_Mutation_p.T168A|MYO7A_ENST00000409619.2_Missense_Mutation_p.T157A	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	168	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GACGGAGAGCACAAAGCTGAT	0.617000													7	184					0	0	1	0	0
EIF2B5	8893	broad.mit.edu	37	3	183856019	183856019	+	Silent	SNP	C	C	T			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr3:183856019C>T	ENST00000273783.3	+	5	872	c.750C>T	c.(748-750)agC>agT	p.S250S	EIF2B5_ENST00000444495.1_Silent_p.S250S	NM_003907.2	NP_003898.2	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	250					astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(5)|urinary_tract(1)	27	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GTCATATCAGCATCTGTTCTC	0.468000													9	96					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37414918	37414918	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr10:37414918T>C	ENST00000374660.1	+	1	134	c.35T>C	c.(34-36)aTa>aCa	p.I12T	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.I12T|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.I12T			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	68						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AACCTTAATATACAAGACGCC	0.592000													3	39					0	0	1	0	0
PRPF39	55015	broad.mit.edu	37	14	45579424	45579424	+	Splice_Site	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr14:45579424G>A	ENST00000355765.6	+	9	1473		c.e9+1			NM_017922.3	NP_060392.3	Q86UA1	PRP39_HUMAN	pre-mRNA processing factor 39						mRNA processing|RNA splicing	nucleus	binding			breast(2)|endometrium(2)|kidney(4)|lung(3)|ovary(1)	12						GAACAGCAGGGTAAGAGTGGA	0.418000													3	40					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64599082	64599082	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr14:64599082G>A	ENST00000357395.3	+	78	14739	c.3595G>A	c.(3595-3597)Gaa>Aaa	p.E1199K	SYNE2_ENST00000344113.4_Missense_Mutation_p.E4814K|SYNE2_ENST00000554584.1_Missense_Mutation_p.E4731K|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000394768.2_Missense_Mutation_p.E1199K|SYNE2_ENST00000358025.3_Missense_Mutation_p.E4814K|SYNE2_ENST00000555002.1_Missense_Mutation_p.E1448K			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4814					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATTTTGGGCAGAACAAGTAAC	0.383000													3	114					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	38					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2369769	2369769	+	Missense_Mutation	SNP	G	G	A			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr16:2369769G>A	ENST00000301732.5	-	8	1386	c.686C>T	c.(685-687)gCc>gTc	p.A229V	ABCA3_ENST00000382381.3_Missense_Mutation_p.A229V	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	229					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				GCGTGTGGCGGCATCGGCATG	0.637000													3	144					0	0	1	0	0
ZNF426	79088	broad.mit.edu	37	19	9640216	9640216	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr19:9640216T>C	ENST00000593003.1	-	6	868	c.391A>G	c.(391-393)Agt>Ggt	p.S131G	ZNF426_ENST00000535489.1_Missense_Mutation_p.S169G|ZNF426_ENST00000589289.1_3'UTR|ZNF426_ENST00000253115.2_Missense_Mutation_p.S169G			Q9BUY5	ZN426_HUMAN	zinc finger protein 426	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20						TTCCCTGTACTTTGAGTTCTC	0.428000													8	78					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32739980	32739980	+	Missense_Mutation	SNP	T	T	C			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr1:32739980T>C	ENST00000333070.4	+	2	150	c.50T>C	c.(49-51)aTc>aCc	p.I17T	LCK_ENST00000373564.3_Missense_Mutation_p.I17T|LCK_ENST00000336890.5_Missense_Mutation_p.I17T	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	17	Interactions with CD4 and CD8 (By similarity).				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	ATGGAAAACATCGATGTGTGT	0.577000			T	TRB@	T-ALL								4	215					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72658179	72658179	+	RNA	SNP	T	T	C	rs147293416	by1000genomes	TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr7:72658179T>C	ENST00000425256.1	-	0	1732					NR_002164.1																						cagagtgatttcggatgaatt	0.507000													3	81					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400841	195400841	+	RNA	SNP	C	C	A	rs7615369	by1000genomes	TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr3:195400841C>A	ENST00000445430.1	+	0	1437																											CTGAGCATCGCAGAGTCGTGC	0.552000													4	39					0.000673444	0.000689869	1	1	0
PVRL4	81607	broad.mit.edu	37	1	161059028	161059030	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr1:161059028_161059030delAGC	ENST00000368012.3	-	1	359_361	c.57_59delGCT	c.(55-60)cta>ct	p.LL21del		NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	21					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TGCCAGCAGTAGCAGCAGCAGCA	0.567													7	289	---	---	---	---					
LRPPRC	10128	broad.mit.edu	37	2	44145165	44145165	+	Splice_Site	DEL	T	T	-			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr2:44145165delT	ENST00000260665.7	-	29	3204	c.3148_splice	c.e29+1	p.K1049_splice		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	1049					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGTGCTTGCCTTTTTTTTGGT	0.453													8	57	---	---	---	---					
RP11-6B4.1	0	broad.mit.edu	37	3	81115695	81115696	+	RNA	DEL	CT	CT	-	rs147076463	by1000genomes	TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr3:81115695_81115696delCT	ENST00000482617.1	+	0	60																											cctcctcctcctctctctctct	0.515													4	3	---	---	---	---					
TUSC1	286319	broad.mit.edu	37	9	25678177	25678178	+	In_Frame_Ins	INS	-	-	CGC			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr9:25678177_25678178insCGC	ENST00000358022.3	-	1	678_679	c.142_143insGCG	c.(142-144)ggg>GCGggg	p.47_48insA		NM_001004125.2	NP_001004125.1	Q2TAM9	TUSC1_HUMAN	tumor suppressor candidate 1	47	Gly-rich.									kidney(1)	1	all_hematologic(1;0.197)	all_neural(3;5.42e-18)|Glioma(3;5.54e-17)		GBM - Glioblastoma multiforme(1;1.51e-108)|Lung(42;2.88e-14)|LUSC - Lung squamous cell carcinoma(38;3.16e-11)		tcgccagcccacgccgccgccg	0.797													3	3	---	---	---	---					
TM7SF2	7108	broad.mit.edu	37	11	64879505	64879506	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr11:64879505_64879506delCC	ENST00000279263.7	+	1	180_181	c.18_19delCC	c.(16-21)ggccfs	p.GP6fs	TM7SF2_ENST00000540748.1_5'UTR|TM7SF2_ENST00000345348.5_Frame_Shift_Del_p.GP6fs	NM_003273.2	NP_003264.2	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	6					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CCACTCAGGGCCCCCGGGCCCC	0.639													6	12	---	---	---	---					
PRPF40B	25766	broad.mit.edu	37	12	50025258	50025258	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr12:50025258delC	ENST00000261897.1	+	2	626	c.75delC	c.(73-75)atfs	p.I25fs	PRPF40B_ENST00000380281.1_Frame_Shift_Del_p.I31fs|PRPF40B_ENST00000548825.2_Frame_Shift_Del_p.I53fs			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	31	Pro-rich.				mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						CACCAGCTATCCCCCCCATGC	0.607													7	362	---	---	---	---					
AC026495.1	0	broad.mit.edu	37	15	20563408	20563417	+	RNA	DEL	CCTCTCCCTT	CCTCTCCCTT	-			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr15:20563408_20563417delCCTCTCCCTT	ENST00000581090.1	+	0	48_57																											CCTCCCAGAGcctctcccttcctctccctt	0.671													3	4	---	---	---	---					
SPTBN5	51332	broad.mit.edu	37	15	42159282	42159282	+	Frame_Shift_Del	DEL	G	G	-			TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr15:42159282delG	ENST00000320955.6	-	36	6582	c.6355delC	c.(6355-6357)ggfs	p.R2119fs		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2119					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TCCCGCACCCGGGGGCGCCGG	0.731													2	4	---	---	---	---					
ITGB4	3691	broad.mit.edu	37	17	73732157	73732158	+	Frame_Shift_Del	DEL	GT	GT	-	rs121912463		TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr17:73732157_73732158delGT	ENST00000200181.3	+	14	1870_1871	c.1683_1684delGT	c.(1681-1686)cagtfs	p.QC561fs	ITGB4_ENST00000450894.3_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000449880.2_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000339591.3_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000579662.1_Frame_Shift_Del_p.QC561fs	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	561	Cysteine-rich tandem repeats.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCATGGGCCAGTGTGTGTGTGA	0.604													8	401	---	---	---	---					
AP003900.6	0	broad.mit.edu	37	21	11180762	11180762	+	RNA	DEL	T	T	-	rs146742149		TCGA-EL-A3T0-01A-22D-A22D-08	TCGA-EL-A3T0-11A-12D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	54426b1a-e0d3-4d8e-9e81-2d8e6b153b22	93f3e9bc-7221-4442-af55-1004bdf61842	g.chr21:11180762delT	ENST00000603265.1	+	0	231																											aACTAACTTCTTTTTTTTTTT	0.348													3	3	---	---	---	---					
