Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM66D	0	broad.mit.edu	37	8	11986719	11986719	+	RNA	SNP	G	G	C			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr8:11986719G>C	ENST00000434078.2	+	0	608					NR_027425.1																						TGGATTTCAGGAAAAGCTGCA	0.522000													4	152					0	0	0.009096	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													4	105					0	0	0.001168	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40308702	40308702	+	Splice_Site	SNP	G	G	A			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr15:40308702G>A	ENST00000263791.5	+	28	3802		c.e28-1		EIF2AK4_ENST00000382727.2_Splice_Site	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4						translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TTGCTTTCCAGCTGTGTCGAC	0.473000													3	49					0	0	0.009096	0	0
NOTCH2	4853	broad.mit.edu	37	1	120461954	120461954	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr1:120461954T>G	ENST00000256646.2	-	31	5981	c.5762A>C	c.(5761-5763)gAt>gCt	p.D1921A		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1921					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACCTTGGGCATCAGCTGCCAC	0.468000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				3	83					0	0	0.004672	0	0
IGDCC4	57722	broad.mit.edu	37	15	65677333	65677333	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr15:65677333G>A	ENST00000352385.2	-	19	3510	c.3301C>T	c.(3301-3303)Cag>Tag	p.Q1101*	IGDCC4_ENST00000558048.1_5'UTR	NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1101						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						AACAGCGTCTGCCCAGTTCCA	0.662000											OREG0023195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	129					0	0	0.001168	0	0
HRAS	3265	broad.mit.edu	37	11	533875	533875	+	Missense_Mutation	SNP	G	G	T	rs28933406		TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr11:533875G>T	ENST00000417302.1	-	3	368	c.181C>A	c.(181-183)Cag>Aag	p.Q61K	HRAS_ENST00000397594.1_Missense_Mutation_p.Q61K|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61K|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61K|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61K|HRAS_ENST00000468682.2_5'UTR	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61K(61)|p.Q61R(1)|p.Q61E(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TACTCCTCCTGGCCGGCGGTA	0.597000		6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			47	81					3.68337e-26	9.20843e-26	0.014410	1	0
NFAT5	10725	broad.mit.edu	37	16	69729160	69729160	+	Silent	SNP	A	A	G			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr16:69729160A>G	ENST00000349945.1	+	15	5806	c.4254A>G	c.(4252-4254)caA>caG	p.Q1418Q	NFAT5_ENST00000566899.1_Silent_p.Q1418Q|NFAT5_ENST00000354436.2_Silent_p.Q1494Q|NFAT5_ENST00000432919.1_Silent_p.Q1512Q|NFAT5_ENST00000393742.2_Silent_p.Q1418Q|NFAT5_ENST00000567239.1_Silent_p.Q1511Q	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	1494					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						TTTCTCAGCAAATGCCAGAGA	0.463000													14	72					0	0	0.001855	0	0
NBPF9	400818	broad.mit.edu	37	1	144828704	144828704	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr1:144828704T>G	ENST00000338347.4	+	14	1750	c.1750T>G	c.(1750-1752)Tac>Gac	p.Y584D	NBPF9_ENST00000468645.1_3'UTR|NBPF9_ENST00000281815.8_Missense_Mutation_p.Y182D|NBPF9_ENST00000440491.2_3'UTR					neuroblastoma breakpoint family, member 9									p.L657L(3)|p.Y584D(1)		NS(2)|prostate(1)	3						CTTCGCCCTTTACGTGGACAA	0.438000													4	223					0	0	0.003080	0	0
TIAM2	26230	broad.mit.edu	37	6	155458519	155458519	+	Missense_Mutation	SNP	T	T	A			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr6:155458519T>A	ENST00000461783.3	+	7	2676	c.1403T>A	c.(1402-1404)aTg>aAg	p.M468K	TIAM2_ENST00000360366.4_Missense_Mutation_p.M468K|TIAM2_ENST00000456144.1_Missense_Mutation_p.M468K|TIAM2_ENST00000529824.2_Missense_Mutation_p.M468K|TIAM2_ENST00000318981.5_Missense_Mutation_p.M468K|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	468					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GAGTTGGAAATGAGCAGGACC	0.493000													6	171					0	0	0.001168	0	0
LAMP5	24141	broad.mit.edu	37	20	9498782	9498782	+	Missense_Mutation	SNP	G	G	T			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr20:9498782G>T	ENST00000246070.2	+	5	1063	c.571G>T	c.(571-573)Gcc>Tcc	p.A191S	LAMP5_ENST00000427562.2_Missense_Mutation_p.A147S	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	191						integral to membrane											CATTTCACTGGCCTCTAGTGA	0.507000													24	44					2.21704e-12	5.41369e-12	0.002780	1	0
CCDC150	284992	broad.mit.edu	37	2	197521549	197521549	+	Silent	SNP	T	T	A			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr2:197521549T>A	ENST00000389175.4	+	3	504	c.369T>A	c.(367-369)acT>acA	p.T123T	CCDC150_ENST00000423093.2_Intron|CCDC150_ENST00000472405.2_Silent_p.T20T|CCDC150_ENST00000272831.7_Intron	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	123										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GGCTGCAAACTGAAAAGGATT	0.388000													4	46					0	0	0.009096	0	0
TRIB2	28951	broad.mit.edu	37	2	12864844	12864844	+	Missense_Mutation	SNP	A	A	C			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr2:12864844A>C	ENST00000405331.3	+	3	723	c.653A>C	c.(652-654)cAc>cCc	p.H218P	TRIB2_ENST00000155926.4_Intron|TRIB2_ENST00000381465.2_Intron			Q92519	TRIB2_HUMAN	tribbles pseudokinase 2	0	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(5)|prostate(1)|skin(1)|stomach(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTCTGTTTCCACCCTCCCCCT	0.473000													11	350					0	0	0.006320	0	0
XPNPEP1	7511	broad.mit.edu	37	10	111642324	111642324	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr10:111642324C>T	ENST00000369680.4	-	10	1026	c.778G>A	c.(778-780)Gaa>Aaa	p.E260K	XPNPEP1_ENST00000430337.1_5'UTR|XPNPEP1_ENST00000322238.8_Missense_Mutation_p.E303K|XPNPEP1_ENST00000369683.1_Missense_Mutation_p.E189K|XPNPEP1_ENST00000502935.1_Missense_Mutation_p.E303K	NM_020383.3	NP_065116.3	Q9NQW7	XPP1_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	260					bradykinin catabolic process|proteolysis		manganese ion binding|metalloaminopeptidase activity|protein homodimerization activity			endometrium(2)|kidney(9)|large_intestine(4)|lung(9)|ovary(3)|pancreas(2)|skin(1)|urinary_tract(1)	31		Breast(234;0.174)		Epithelial(162;1.64e-05)|all cancers(201;0.000564)|BRCA - Breast invasive adenocarcinoma(275;0.0721)		ATCCTGTATTCGGCTTCCAGA	0.572000													36	82					0	0	0.004878	0	0
DLGAP5	9787	broad.mit.edu	37	14	55637441	55637441	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr14:55637441C>G	ENST00000247191.2	-	11	1582	c.1366G>C	c.(1366-1368)Gaa>Caa	p.E456Q	DLGAP5_ENST00000395425.2_Missense_Mutation_p.E456Q	NM_014750.4	NP_055565.3	Q15398	DLGP5_HUMAN	discs, large (Drosophila) homolog-associated protein 5	456					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			biliary_tract(1)|breast(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	44						ATGTCCAATTCAAGTTTCCTG	0.333000													28	40					0	0	0.009535	0	0
MROH1	727957	broad.mit.edu	37	8	145235189	145235189	+	Missense_Mutation	SNP	A	A	C			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr8:145235189A>C	ENST00000528919.1	+	5	530	c.409A>C	c.(409-411)Acc>Ccc	p.T137P	MROH1_ENST00000534366.1_Missense_Mutation_p.T137P|MROH1_ENST00000423230.2_Missense_Mutation_p.T137P|MROH1_ENST00000326134.5_Missense_Mutation_p.T137P|MROH1_ENST00000398656.4_Missense_Mutation_p.T137P	NM_032450.2	NP_115826.2			maestro heat-like repeat family member 1																		GCACCCTGGGACCCTGCCACA	0.697000													5	50					0	0	0.004482	0	0
TMEM143	55260	broad.mit.edu	37	19	48863423	48863423	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr19:48863423G>C	ENST00000293261.3	-	3	591	c.275C>G	c.(274-276)tCg>tGg	p.S92W	TMEM143_ENST00000436660.2_Missense_Mutation_p.S92W|TMEM143_ENST00000377431.2_Intron|TMEM143_ENST00000435956.3_Intron|TMEM143_ENST00000541566.1_Intron	NM_018273.2	NP_060743.2	Q96AN5	TM143_HUMAN	transmembrane protein 143	92						integral to membrane|mitochondrion				endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	14		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		TGCCGGACTCGAGTGGAATTC	0.562000													3	57					0	0	0.009096	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													4	92					0	0	0.009096	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													7	53					0	0	0.003080	0	0
FAM66D	0	broad.mit.edu	37	8	11986736	11986736	+	RNA	SNP	T	T	C			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr8:11986736T>C	ENST00000434078.2	+	0	608					NR_027425.1																						TGCATCTGGCTGAGAAGATGT	0.507000													4	156					0	0	0.009096	0	0
AKAP11	11215	broad.mit.edu	37	13	42874704	42874704	+	Nonsense_Mutation	SNP	A	A	T			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr13:42874704A>T	ENST00000025301.2	+	8	1997	c.1822A>T	c.(1822-1824)Aaa>Taa	p.K608*		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	608					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		ATTTTCACTAAAAGAACGTGC	0.383000													5	42					0	0	0.000602	0	0
COL4A4	1286	broad.mit.edu	37	2	227979396	227979396	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr2:227979396T>C	ENST00000396625.3	-	8	713	c.506A>G	c.(505-507)aAg>aGg	p.K169R	COL4A4_ENST00000329662.7_Missense_Mutation_p.K169R	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	169	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTTTTCTCCCTTTTCCCCAGG	0.299000													3	55					0	0	0.004672	0	0
ZXDB	158586	broad.mit.edu	37	X	57619097	57619097	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chrX:57619097G>A	ENST00000374888.1	+	1	829	c.616G>A	c.(616-618)Ggg>Agg	p.G206R		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding	p.G206R(2)		NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						CCAGCAGCCCGGGTGTCTGAT	0.711000													3	38					0	0	0.004672	0	0
AC024560.3	0	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	A	G	rs144273946	by1000genomes	TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr3:197348674A>G	ENST00000418868.1	-	0	585					NR_003266.2																						GGCTCTGTCCACCAAATGCAC	0.478000													3	69					0	0	0.004672	0	0
KIAA0100	9703	broad.mit.edu	37	17	26961608	26961608	+	Silent	SNP	A	A	G			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr17:26961608A>G	ENST00000528896.2	-	16	3071	c.2997T>C	c.(2995-2997)ccT>ccC	p.P999P	RP11-192H23.7_ENST00000577814.1_RNA|KIAA0100_ENST00000544884.1_Silent_p.P856P|KIAA0100_ENST00000389003.3_Silent_p.P856P	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	999						extracellular region		p.P999P(1)		breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CAGGGGGAAAAGGGCTGCCTG	0.493000													3	148					0	0	0.009096	0	0
SCUBE1	80274	broad.mit.edu	37	22	43619190	43619190	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr22:43619190A>G	ENST00000360835.3	-	11	1366	c.1240T>C	c.(1240-1242)Tcc>Ccc	p.S414P		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	414					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				GCCCGGGGGGAGGTCTTGGCG	0.647000													4	108					0	0	0.001168	0	0
HLA-DRB6	0	broad.mit.edu	37	6	32522722	32522722	+	RNA	SNP	C	C	A	rs114905475	by1000genomes	TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr6:32522722C>A	ENST00000411500.1	-	0	484					NR_001298.1																						TGGGTCTTTGCAGGATACACA	0.488000													4	31					2.56e-06	6.10909e-06	0.009096	1	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000389562.2_Silent_p.Q2724Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													5	68					0	0	0.000602	0	0
NPIPB6	728741	broad.mit.edu	37	16	28354353	28354353	+	Missense_Mutation	SNP	T	T	G	rs1794256	by1000genomes	TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr16:28354353T>G	ENST00000532254.1	-	7	1538	c.853A>C	c.(853-855)Act>Cct	p.T285P	NPIPB6_ENST00000533640.1_Missense_Mutation_p.T267P					nuclear pore complex interacting protein family, member B6									p.T285P(4)									AGACACTCAGTAGGTGTCTTG	0.507000													4	129					0	0	0.004482	0	0
SIRPB1	10326	broad.mit.edu	37	20	1585397	1585397	+	Missense_Mutation	SNP	T	T	C	rs148754551	by1000genomes	TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr20:1585397T>C	ENST00000279477.7	-	3	806	c.742A>G	c.(742-744)Acc>Gcc	p.T248A	SIRPB1_ENST00000381605.4_Intron|RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000568365.1_Missense_Mutation_p.T248A|SIRPB1_ENST00000381603.3_Intron	NM_001135844.2	NP_001129316.1	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	248					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.T248A(5)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CCTCGGATGGTCTCAGACAAG	0.627000													5	100					0	0	0.000602	0	0
ANTXR2	118429	broad.mit.edu	37	4	80992749	80992749	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr4:80992749T>C	ENST00000403729.2	-	2	737	c.212A>G	c.(211-213)gAg>gGg	p.E71G	ANTXR2_ENST00000346652.6_Missense_Mutation_p.E71G|ANTXR2_ENST00000404191.1_5'UTR|ANTXR2_ENST00000307333.7_Missense_Mutation_p.E71G|ANTXR2_ENST00000295465.4_Missense_Mutation_p.E71G	NM_058172.5	NP_477520.2	P58335	ANTR2_HUMAN	anthrax toxin receptor 2	71	VWFA.					endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	13						CACAAATCTCTCCGCAAGTTG	0.368000									Juvenile Hyaline Fibromatosis				26	26					0	0	0.004656	0	0
ZNF322	79692	broad.mit.edu	37	6	26638435	26638435	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr6:26638435C>G	ENST00000415922.2	-	4	992	c.347G>C	c.(346-348)gGa>gCa	p.G116A	ZNF322_ENST00000471278.1_Missense_Mutation_p.G116A	NM_024639.4	NP_078915.2	Q6U7Q0	Z322A_HUMAN	zinc finger protein 322	116					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding										TCTCTGATGTCCTGAAAGCGC	0.413000													3	126					0	0	0.004672	0	0
MYRIP	25924	broad.mit.edu	37	3	40223732	40223732	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr3:40223732A>G	ENST00000302541.6	+	9	1237	c.895A>G	c.(895-897)Atc>Gtc	p.I299V	MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000444716.1_Missense_Mutation_p.I299V|MYRIP_ENST00000539167.1_Missense_Mutation_p.I112V|MYRIP_ENST00000425621.1_Missense_Mutation_p.I299V|MYRIP_ENST00000396217.3_Missense_Mutation_p.I210V	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	299	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		TGCCTTCTCAATCACTGGAGA	0.592000													4	128					0	0	0.009096	0	0
ALG1L2	0	broad.mit.edu	37	3	129814807	129814807	+	RNA	DEL	G	G	-	rs71158106		TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr3:129814807delG	ENST00000507643.1	+	0	456							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										CACTCCCCTCGGGGGGTGTTG	0.607													2	4	---	---	---	---					
RP11-242J7.1	0	broad.mit.edu	37	4	185536410	185536413	+	RNA	DEL	TTTG	TTTG	-	rs146473442		TCGA-EM-A22K-01A-11D-A17V-08	TCGA-EM-A22K-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04cb54da-f53f-4bdd-9f67-42bf9140da17	b31f64cf-a428-415f-8380-0eb6d368cfd2	g.chr4:185536410_185536413delTTTG	ENST00000522554.1	-	0	292																											CAAAGCCGATtttgtttgtttgtt	0.451													6	8	---	---	---	---					
