Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SCN1A	6323	broad.mit.edu	37	2	166900318	166900318	+	Missense_Mutation	SNP	A	A	C			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr2:166900318A>C	ENST00000423058.2	-	11	1921	c.1904T>G	c.(1903-1905)tTt>tGt	p.F635C	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.F635C|SCN1A_ENST00000375405.3_Missense_Mutation_p.F635C|SCN1A_ENST00000303395.4_Missense_Mutation_p.F635C|AC010127.3_ENST00000595268.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	635						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	ATTCGCTGGAAACACTGCCAG	0.542000													6	67					0	0	1	0	0
VANGL1	81839	broad.mit.edu	37	1	116233873	116233873	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr1:116233873T>G	ENST00000355485.2	+	8	1719	c.1448T>G	c.(1447-1449)cTt>cGt	p.L483R	VANGL1_ENST00000369510.3_Missense_Mutation_p.L481R|VANGL1_ENST00000369509.1_Missense_Mutation_p.L483R|VANGL1_ENST00000310260.3_Missense_Mutation_p.L483R	NM_001172411.1|NM_138959.2	NP_001165882.1|NP_620409.1	Q8TAA9	VANG1_HUMAN	VANGL planar cell polarity protein 1	483					multicellular organismal development	integral to membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(13)|urinary_tract(1)	27	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GTGTTCGTCCTTAAGTGCTTG	0.448000													8	53					0	0	1	0	0
CTD-2620I22.1	0	broad.mit.edu	37	19	53472914	53472914	+	RNA	SNP	A	A	G			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr19:53472914A>G	ENST00000600068.1	-	0	489				ZNF702P_ENST00000270443.4_RNA																							TTTGATTTTCAATTAAAAACC	0.338000													3	11					0	0	1	0	0
RP11-69H14.6	0	broad.mit.edu	37	15	22332570	22332570	+	RNA	SNP	T	T	C			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr15:22332570T>C	ENST00000558896.1	+	0	377																											CCCATGCTCATCTGCTCCAAT	0.398000													6	161					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12885059	12885059	+	Missense_Mutation	SNP	C	C	G	rs143004725	by1000genomes	TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr1:12885059C>G	ENST00000535591.1	-	4	1247	c.1052G>C	c.(1051-1053)tGc>tCc	p.C351S		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	351								p.C351S(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GGTGGCCATGCAGATGGGATT	0.532000													5	152					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166900322	166900322	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr2:166900322C>G	ENST00000423058.2	-	11	1917	c.1900G>C	c.(1900-1902)Gtg>Ctg	p.V634L	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.V634L|SCN1A_ENST00000375405.3_Missense_Mutation_p.V634L|SCN1A_ENST00000303395.4_Missense_Mutation_p.V634L|AC010127.3_ENST00000595268.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	634						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GCTGGAAACACTGCCAGCATC	0.537000													6	68					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112175616	112175616	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr5:112175616C>A	ENST00000457016.1	+	16	4705	c.4325C>A	c.(4324-4326)cCt>cAt	p.P1442H	APC_ENST00000257430.4_Missense_Mutation_p.P1442H|APC_ENST00000508376.2_Missense_Mutation_p.P1442H|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	1442	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)|p.P1442fs*31(1)|p.P1424fs*19(1)|p.K1192fs*3(1)|p.P1441fs*28(1)|p.S1436fs*22(1)|p.P1441fs*27(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CCTCCACCACCTCCTCAAACA	0.473000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			3	40					1	1	1	1	0
BAGE2	85319	broad.mit.edu	37	21	11058340	11058340	+	RNA	SNP	A	A	C	rs28617310	by1000genomes	TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr21:11058340A>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGGTAAAGGAGAGAAATCTC	0.363000													6	106					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94512531	94512531	+	Silent	SNP	G	G	A			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr1:94512531G>A	ENST00000370225.3	-	19	2948	c.2862C>T	c.(2860-2862)taC>taT	p.Y954Y	ABCA4_ENST00000535735.1_Silent_p.Y880Y	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	954	ABC transporter 1.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCTGGTTCTCGTAGAAGGTGA	0.552000													15	153					0	0	1	0	0
PRSS3P2	0	broad.mit.edu	37	7	142482242	142482242	+	RNA	SNP	G	G	A	rs143538588	by1000genomes	TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr7:142482242G>A	ENST00000603901.1	+	0	622					NR_001296.3																						GGTCTGCAATGGACAGCTTCA	0.493000													4	56					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63102170	63102170	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr15:63102170C>A	ENST00000561311.1	+	51	6940	c.6710C>A	c.(6709-6711)gCc>gAc	p.A2237D	TLN2_ENST00000306829.6_Missense_Mutation_p.A2237D			Q9Y4G6	TLN2_HUMAN	talin 2	2237					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						AGAACCAGAGCCTTGCGTTTC	0.552000													3	19					0.0215528	0.0242469	1	1	0
CRISPLD2	83716	broad.mit.edu	37	16	84882990	84882990	+	Splice_Site	SNP	G	G	A			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr16:84882990G>A	ENST00000262424.5	+	4	583		c.e4-1		CRISPLD2_ENST00000567845.1_Splice_Site|CRISPLD2_ENST00000566431.1_Splice_Site|CRISPLD2_ENST00000564567.1_Splice_Site	NM_031476.3	NP_113664.1	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain containing 2							extracellular region|transport vesicle				endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)	18						CTGCCCTGCAGGTATCGCTCT	0.642000													15	22					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													4	142					0	0	1	0	0
ZNF37A	7587	broad.mit.edu	37	10	38407191	38407191	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr10:38407191C>G	ENST00000351773.3	+	8	1942	c.1112C>G	c.(1111-1113)aCt>aGt	p.T371S	ZNF37A_ENST00000361085.4_Missense_Mutation_p.T371S	NM_001007094.2	NP_001007095.1	P17032	ZN37A_HUMAN	zinc finger protein 37A	371						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						TCAGTCCTTACTGTGCATCAG	0.408000													4	73					0	0	1	0	0
RP11-69H14.6	0	broad.mit.edu	37	15	22332432	22332432	+	RNA	SNP	C	C	T			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr15:22332432C>T	ENST00000558896.1	+	0	239																											AAGATTCTAACGTGACAGAAC	0.343000													4	67					0	0	1	0	0
ZNF629	23361	broad.mit.edu	37	16	30794482	30794482	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr16:30794482C>A	ENST00000262525.4	-	3	1374	c.1167G>T	c.(1165-1167)ttG>ttT	p.L389F		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			GGTGCCGCAGCAACGTGGCGC	0.652000													3	25					0.115264	0.125743	1	1	0
TLE4	7091	broad.mit.edu	37	9	82321667	82321667	+	Silent	SNP	A	A	G			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr9:82321667A>G	ENST00000376520.4	+	11	1617	c.789A>G	c.(787-789)ccA>ccG	p.P263P	TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000376537.4_Silent_p.P263P|TLE4_ENST00000376544.3_Intron|TLE4_ENST00000376552.2_Silent_p.P263P|TLE4_ENST00000265284.6_Silent_p.P238P			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						TGTAGGATCCATCTTCCCCTC	0.493000													28	53					0	0	1	0	0
GYPE	2996	broad.mit.edu	37	4	144826671	144826671	+	Translation_Start_Site	SNP	C	C	T			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr4:144826671C>T	ENST00000358615.4	-	0	41				GYPE_ENST00000437468.2_De_novo_Start_OutOfFrame	NM_198682.2	NP_941391.2	P15421	GLPE_HUMAN	glycophorin E (MNS blood group)							integral to plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	all_hematologic(180;0.158)					CCTGAGATCACGAGCTGGCTC	0.398000													3	37					0	0	1	0	0
ALG1L2	0	broad.mit.edu	37	3	129817144	129817144	+	RNA	SNP	G	G	T			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr3:129817144G>T	ENST00000507643.1	+	0	726							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										TGCGGGAGTCGCAGCAGCTCT	0.527000													4	31					0.00198382	0.00230379	1	1	0
EP400	57634	broad.mit.edu	37	12	132472421	132472421	+	Missense_Mutation	SNP	G	G	T			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr12:132472421G>T	ENST00000333577.4	+	8	2612	c.2503G>T	c.(2503-2505)Gct>Tct	p.A835S	EP400_ENST00000389561.2_Missense_Mutation_p.A799S|EP400_ENST00000330386.6_Missense_Mutation_p.A799S|EP400_ENST00000389562.2_Missense_Mutation_p.A798S|EP400_ENST00000332482.4_Missense_Mutation_p.A762S			Q96L91	EP400_HUMAN	E1A binding protein p400	835	HSA.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GTGGAAGGTGGCTGCTGCGAA	0.612000													3	20					1	1	1	1	0
ZNF234	10780	broad.mit.edu	37	19	44660699	44660699	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr19:44660699C>A	ENST00000426739.2	+	6	788	c.530C>A	c.(529-531)aCa>aAa	p.T177K	ZNF234_ENST00000592437.1_Missense_Mutation_p.T177K	NM_006630.2	NP_006621.1	Q14588	ZN234_HUMAN	zinc finger protein 234	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)	23		Prostate(69;0.0435)				AAGTCTCATACATGTGATGAG	0.393000													16	102					5.01169e-05	6.22141e-05	1	1	0
BAGE2	85319	broad.mit.edu	37	21	11058348	11058348	+	RNA	SNP	C	C	A			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr21:11058348C>A	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGAGAGAAATCTCTTTATAAA	0.343000													6	90					8.12818e-05	9.75382e-05	1	1	0
NAA30	122830	broad.mit.edu	37	14	57863556	57863556	+	Missense_Mutation	SNP	G	G	T			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr14:57863556G>T	ENST00000556492.1	+	3	1012	c.858G>T	c.(856-858)atG>atT	p.M286I	NAA30_ENST00000555166.1_Missense_Mutation_p.M28I|NAA30_ENST00000554703.1_Missense_Mutation_p.M28I	NM_001011713.2	NP_001011713.2	Q147X3	NAA30_HUMAN	N(alpha)-acetyltransferase 30, NatC catalytic subunit	286	N-acetyltransferase.					cytoplasm	peptide alpha-N-acetyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(2)|skin(2)	13						ATATAGCCATGTTAGCCGTGG	0.373000													9	36					3.09899e-07	3.98441e-07	1	1	0
ALG1L2	0	broad.mit.edu	37	3	129817138	129817138	+	RNA	SNP	G	G	A			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr3:129817138G>A	ENST00000507643.1	+	0	720							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										AGAACCTGCGGGAGTCGCAGC	0.522000													4	32					0	0	1	0	0
ABLIM2	84448	broad.mit.edu	37	4	7985069	7985069	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr4:7985069G>C	ENST00000318888.4	-	19	1720	c.849C>G	c.(847-849)atC>atG	p.I283M	ABLIM2_ENST00000546334.1_Missense_Mutation_p.I468M|ABLIM2_ENST00000447017.2_Missense_Mutation_p.I582M|ABLIM2_ENST00000505872.1_Missense_Mutation_p.I496M|ABLIM2_ENST00000407564.3_Missense_Mutation_p.I458M|ABLIM2_ENST00000296372.8_Missense_Mutation_p.I510M|ABLIM2_ENST00000341937.5_Missense_Mutation_p.I548M|ABLIM2_ENST00000361737.5_Missense_Mutation_p.I468M|ABLIM2_ENST00000361581.5_Missense_Mutation_p.I509M|ABLIM2_ENST00000514025.1_Missense_Mutation_p.I283M|ABLIM2_ENST00000545242.1_Missense_Mutation_p.I508M			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	548					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						CATACGGATAGATCTGTTGGG	0.552000													9	8					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55032442	55032442	+	Silent	SNP	C	C	T			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr11:55032442C>T	ENST00000417545.2	+	2	197	c.111C>T	c.(109-111)taC>taT	p.Y37Y		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	21						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GCATGAACTACTTCATAGACC	0.478000													9	174					0	0	1	0	0
ALG1L2	0	broad.mit.edu	37	3	129817127	129817127	+	RNA	SNP	A	A	C			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr3:129817127A>C	ENST00000507643.1	+	0	709							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										CCAGTTCCGGAAGAACCTGCG	0.522000													4	31					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994614	140994614	+	Missense_Mutation	SNP	A	A	T			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chrX:140994614A>T	ENST00000285879.4	+	4	1710	c.1424A>T	c.(1423-1425)cAg>cTg	p.Q475L	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	475							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GGTTTTCCCCAGTCTCCTCTC	0.478000										HNSCC(15;0.026)			82	167					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65499273	65499273	+	Missense_Mutation	SNP	G	G	A	rs148640463		TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr15:65499273G>A	ENST00000261883.4	-	4	437	c.271C>T	c.(271-273)Cgg>Tgg	p.R91W		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	91					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						GCCTCTAGCCGCAGGGGACGG	0.617000													3	22					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				11	28					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325961	79325961	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr9:79325961T>C	ENST00000428286.1	-	8	1352	c.152A>G	c.(151-153)aAt>aGt	p.N51S	PRUNE2_ENST00000376718.3_Missense_Mutation_p.N410S			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	410					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GTTAGAATCATTGAGATCTGG	0.512000													3	26					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	114952912	114952912	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr1:114952912T>G	ENST00000358465.2	-	12	2171	c.2088A>C	c.(2086-2088)ttA>ttC	p.L696F	TRIM33_ENST00000450349.2_Missense_Mutation_p.L328F|TRIM33_ENST00000369543.2_Missense_Mutation_p.L696F	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	696			L -> S (in dbSNP:rs56151583).		negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTAGATTATCTAAACTACTTG	0.413000			T	RET	papillary thyroid								11	27					0	0	1	0	0
MORN5	254956	broad.mit.edu	37	9	124936866	124936866	+	Missense_Mutation	SNP	G	G	T			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr9:124936866G>T	ENST00000536616.1	+	4	437	c.399G>T	c.(397-399)agG>agT	p.R133S	MORN5_ENST00000373764.3_Missense_Mutation_p.R133S|MORN5_ENST00000486801.1_3'UTR			Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	133										endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	9						CAGTCACGAGGGTAGTCAAGG	0.468000													6	68					2.7689e-08	3.69186e-08	1	1	0
BAGE2	85319	broad.mit.edu	37	21	11058248	11058248	+	RNA	SNP	G	G	A	rs8130203	by1000genomes	TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr21:11058248G>A	ENST00000470054.1	-	0	399									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCAGCACAAGGATAATGATAC	0.433000													4	78					0	0	1	0	0
ZNF639	51193	broad.mit.edu	37	3	179051912	179051913	+	Frame_Shift_Ins	INS	-	-	A			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr3:179051912_179051913insA	ENST00000326361.3	+	7	1605_1606	c.1160_1161insA	c.(1159-1161)aaafs	p.K387fs	ZNF639_ENST00000484866.1_Frame_Shift_Ins_p.K387fs|ZNF639_ENST00000496856.1_Frame_Shift_Ins_p.K387fs	NM_016331.1	NP_057415.1	Q9UID6	ZN639_HUMAN	zinc finger protein 639	387	Interaction with CTNNA2.				initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(10)|urinary_tract(1)	16	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			AGACTTCACACAAATGTTAACA	0.356													29	107	---	---	---	---					
INTS4L2	0	broad.mit.edu	37	7	65150817	65150817	+	RNA	DEL	C	C	-			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr7:65150817delC	ENST00000430126.2	+	0	757																											TCATCCCTCACCCCCCCCCCC	0.468													4	7	---	---	---	---					
AZGP1P1	0	broad.mit.edu	37	7	99578706	99578706	+	RNA	DEL	A	A	-			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr7:99578706delA	ENST00000425474.1	+	0	87					NR_036679.1																						cttagtttacagtgaaaacaa	0.522													2	4	---	---	---	---					
OTUD6B	51633	broad.mit.edu	37	8	92096277	92096277	+	Frame_Shift_Del	DEL	A	A	-			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr8:92096277delA	ENST00000285420.4	+	6	921	c.822delA	c.(820-822)atfs	p.I275fs	OTUD6B_ENST00000404789.3_Frame_Shift_Del_p.I144fs	NM_016023.3	NP_057107.3	Q8N6M0	OTU6B_HUMAN	OTU domain containing 6B	245	OTU.									endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11			BRCA - Breast invasive adenocarcinoma(11;0.0187)			CAATAGAGATAATACAGGCAG	0.294													2	4	---	---	---	---					
MRGPRX4	117196	broad.mit.edu	37	11	18195357	18195357	+	Frame_Shift_Del	DEL	T	T	-			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr11:18195357delT	ENST00000314254.3	+	1	974	c.554delT	c.(553-555)atfs	p.I185fs	RP11-113D6.6_ENST00000527671.1_Intron	NM_054032.3	NP_473373.2	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	185						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						GCGTGGCTGATTTTTTTATGT	0.507													17	131	---	---	---	---					
AVIL	10677	broad.mit.edu	37	12	58209957	58209958	+	Translation_Start_Site	INS	-	-	TGG			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr12:58209957_58209958insTGG	ENST00000257861.3	-	0	296_297					NM_006576.3	NP_006567.3	O75366	AVIL_HUMAN	advillin						actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CCACACCCTCATGGTGCATCCC	0.540													4	2	---	---	---	---					
GOLGA6B	55889	broad.mit.edu	37	15	72957311	72957313	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr15:72957311_72957313delGAG	ENST00000421285.3	+	14	1528_1530	c.1528_1530delGAG	c.(1528-1530)del	p.E513del		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	513										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						TCTGGACAGTGAGGAGGAGGAGG	0.635													5	6	---	---	---	---					
ABCA17P	0	broad.mit.edu	37	16	2474780	2474780	+	RNA	DEL	C	C	-			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr16:2474780delC	ENST00000469908.1	+	0	2937					NR_003574.1																						TGTGTGCCGGCCCCGGCAGCC	0.672													2	4	---	---	---	---					
RP11-44F14.1	0	broad.mit.edu	37	16	53404542	53404543	+	RNA	INS	-	-	A			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr16:53404542_53404543insA	ENST00000565421.1	-	0	410																											TCTCCTTTCTCAAACTTAACCT	0.327													7	19	---	---	---	---					
CCDC9	26093	broad.mit.edu	37	19	47768151	47768151	+	Frame_Shift_Del	DEL	G	G	-			TCGA-EM-A3SZ-01A-11D-A22Z-08	TCGA-EM-A3SZ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	114ee66b-9e70-492c-8644-43956553c557	cfb11db4-04a4-44ea-bf61-1518475fd677	g.chr19:47768151delG	ENST00000221922.6	+	7	890	c.668delG	c.(667-669)tgfs	p.W223fs		NM_015603.2	NP_056418.1	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	223										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|urinary_tract(1)	12		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		GGCCGCAACTGGGGGGGCCCC	0.721													3	4	---	---	---	---					
