Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTN	7273	broad.mit.edu	37	2	179611913	179611913	+	Silent	SNP	T	T	G			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr2:179611913T>G	ENST00000360870.5	-	46	15436	c.15214A>C	c.(15214-15216)Aga>Cga	p.R5072R	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000589042.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	1179	Ig-like 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGAGTATCTCTCTAGAGTC	0.532000													4	79					0	0	1	0	0
LIPK	643414	broad.mit.edu	37	10	90490787	90490787	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr10:90490787A>G	ENST00000404190.1	+	3	271	c.271A>G	c.(271-273)Agt>Ggt	p.S91G		NM_001080518.1	NP_001073987.1	Q5VXJ0	LIPK_HUMAN	lipase, family member K	91					lipid catabolic process	extracellular region	hydrolase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	12		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		TGCATCTGCCAGTAACTGGAT	0.458000													4	6					0	0	1	0	0
PHLPP1	23239	broad.mit.edu	37	18	60645971	60645971	+	Silent	SNP	C	C	T			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr18:60645971C>T	ENST00000400316.4	+	17	4706	c.2925C>T	c.(2923-2925)agC>agT	p.S975S	PHLPP1_ENST00000262719.5_Silent_p.S1487S	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1487					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						CTGAGATGAGCAGCGAGGTGG	0.642000													3	19					0	0	1	0	0
GRIA4	0	broad.mit.edu	37	11	105732820	105732820	+	Silent	SNP	G	G	T			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr11:105732820G>T	ENST00000393127.2	+	5	1004	c.558G>T	c.(556-558)gtG>gtT	p.V186V	GRIA4_ENST00000530497.1_Silent_p.V186V|GRIA4_ENST00000282499.5_Silent_p.V186V|GRIA4_ENST00000525187.1_Silent_p.V186V|GRIA4_ENST00000428631.2_Silent_p.V186V|GRIA4_ENST00000393125.2_Silent_p.V186V	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	186					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	CTATATGTGTGGAAAATTTTA	0.358000													10	31					5.50884e-06	5.9169e-06	1	1	0
PRB4	5545	broad.mit.edu	37	12	11461589	11461589	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr12:11461589A>G	ENST00000279575.1	-	3	361	c.328T>C	c.(328-330)Tcc>Ccc	p.S110P	PRB4_ENST00000445719.2_Missense_Mutation_p.S110P|PRB4_ENST00000535904.1_Missense_Mutation_p.S110P	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	152	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.					extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						GTACCTTGGGACTGGTTTCCT	0.602000										HNSCC(22;0.051)			6	366					0	0	1	0	0
RIMS1	0	broad.mit.edu	37	6	73110295	73110295	+	Missense_Mutation	SNP	T	T	A			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr6:73110295T>A	ENST00000264839.7	+	30	4505	c.4505T>A	c.(4504-4506)aTc>aAc	p.I1502N	RIMS1_ENST00000491071.2_Missense_Mutation_p.I1442N|RIMS1_ENST00000521978.1_Missense_Mutation_p.I1653N|RIMS1_ENST00000431478.2_3'UTR|RIMS1_ENST00000517827.1_Missense_Mutation_p.I787N|RIMS1_ENST00000348717.5_Missense_Mutation_p.I1436N|RIMS1_ENST00000517960.1_Missense_Mutation_p.I1436N|RIMS1_ENST00000538414.1_Missense_Mutation_p.I459N|RIMS1_ENST00000425662.2_Missense_Mutation_p.I721N|RIMS1_ENST00000523963.1_Missense_Mutation_p.I778N|RIMS1_ENST00000401910.3_Missense_Mutation_p.I973N|RIMS1_ENST00000414192.2_Missense_Mutation_p.I180N|RIMS1_ENST00000518273.1_Missense_Mutation_p.I1332N|RIMS1_ENST00000520567.1_Missense_Mutation_p.I1303N|RIMS1_ENST00000522291.1_Missense_Mutation_p.I1252N			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1653					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AGCATGGTGATCGGATGGTAC	0.537000													28	43					0	0	1	0	0
AGFG1	3267	broad.mit.edu	37	2	228399693	228399693	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr2:228399693C>A	ENST00000310078.7	+	8	1417	c.1157C>A	c.(1156-1158)tCt>tAt	p.S386Y	AGFG1_ENST00000409315.1_Missense_Mutation_p.S365Y|AGFG1_ENST00000409979.2_Missense_Mutation_p.S410Y|AGFG1_ENST00000373671.3_Missense_Mutation_p.S346Y|AGFG1_ENST00000409171.1_Missense_Mutation_p.S386Y	NM_001135188.1|NM_004504.4	NP_001128660.1|NP_004495.2	P52594	AGFG1_HUMAN	ArfGAP with FG repeats 1	386					cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(2)|ovary(1)|prostate(1)|skin(4)|stomach(1)	18						GTTTTCAGTTCTGCAGCCACC	0.453000													22	47					4.72057e-08	5.26525e-08	1	1	0
TRIM11	81559	broad.mit.edu	37	1	228588714	228588714	+	Missense_Mutation	SNP	A	A	T			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr1:228588714A>T	ENST00000493030.2	-	2	4020	c.311T>A	c.(310-312)aTc>aAc	p.I104N	TRIM11_ENST00000366699.3_Missense_Mutation_p.I229N|TRIM11_ENST00000460651.1_5'UTR|TRIM11_ENST00000284551.6_Missense_Mutation_p.I229N			Q96F44	TRI11_HUMAN	tripartite motif containing 11	229					response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	18		Prostate(94;0.0724)				GAGCTCGGCGATGAGCTCAGC	0.721000													7	9					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242063411	242063411	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr2:242063411A>G	ENST00000403638.3	-	11	2948	c.2857T>C	c.(2857-2859)Tcc>Ccc	p.S953P	PASK_ENST00000405260.1_Missense_Mutation_p.S953P|PASK_ENST00000544142.1_Missense_Mutation_p.S767P|PASK_ENST00000539818.1_Missense_Mutation_p.S737P|PASK_ENST00000358649.4_Missense_Mutation_p.S953P|PASK_ENST00000234040.4_Missense_Mutation_p.S953P	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	953					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GAGTGGGTGGAGCCGGGCAGG	0.622000													3	43					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76427339	76427339	+	Missense_Mutation	SNP	T	T	A			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr13:76427339T>A	ENST00000357063.3	+	29	5892	c.4632T>A	c.(4630-4632)agT>agA	p.S1544R	LMO7_ENST00000526202.1_Missense_Mutation_p.S1136R|LMO7_ENST00000321797.8_Missense_Mutation_p.S1259R|LMO7_ENST00000377534.3_Missense_Mutation_p.S1544R|LMO7_ENST00000465261.2_Missense_Mutation_p.S1259R|LMO7_ENST00000341547.4_Missense_Mutation_p.S1210R			Q8WWI1	LMO7_HUMAN	LIM domain 7	1544						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AAGACTTTAGTCGCCCACCAC	0.567000													19	28					0	0	1	0	0
DRD5	0	broad.mit.edu	37	4	9784098	9784098	+	Missense_Mutation	SNP	A	A	G	rs138634841		TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr4:9784098A>G	ENST00000304374.2	+	1	841	c.445A>G	c.(445-447)Aag>Gag	p.K149E		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	149					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane		p.K149E(1)		NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CTTCCGCTACAAGCGCAAGAT	0.597000													3	25					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907980	12907980	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr1:12907980C>T	ENST00000317869.6	-	2	388	c.163G>A	c.(163-165)Gtt>Att	p.V55I		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1									p.V55I(1)		NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TCATATTGAACGAAGGCAAAG	0.473000													23	147					0	0	1	0	0
BTN3A3	10384	broad.mit.edu	37	6	26448653	26448653	+	Missense_Mutation	SNP	C	C	A			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr6:26448653C>A	ENST00000244519.2	+	6	1136	c.893C>A	c.(892-894)aCa>aAa	p.T298K	BTN3A3_ENST00000339789.4_Missense_Mutation_p.T256K|BTN3A3_ENST00000361232.3_Missense_Mutation_p.T256K	NM_006994.4	NP_008925.1	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3	298						integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						TACGCTGCAACAGAGCAAGAA	0.498000													16	21					2.32078e-09	2.69211e-09	1	1	0
PRB4	5545	broad.mit.edu	37	12	11461583	11461583	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr12:11461583C>G	ENST00000279575.1	-	3	367	c.334G>C	c.(334-336)Ggt>Cgt	p.G112R	PRB4_ENST00000445719.2_Splice_Site_p.G112_splice|PRB4_ENST00000535904.1_Missense_Mutation_p.G112R	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	154	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.					extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						GGTGGGGTACCTTGGGACTGG	0.607000										HNSCC(22;0.051)			6	365					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017526	1017526	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr11:1017526G>C	ENST00000421673.2	-	31	5325	c.5275C>G	c.(5275-5277)Cct>Gct	p.P1759A		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1759	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTGACTTCAGGATGGTGTGTG	0.562000													7	848					0	0	1	0	0
AKR7L	246181	broad.mit.edu	37	1	19596156	19596156	+	RNA	SNP	G	G	T	rs6665756	by1000genomes	TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr1:19596156G>T	ENST00000420396.2	-	0	507				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						CCTGCCGGGTGGTGGCGCTGT	0.562000													3	40					0.004672	0.00483886	1	1	0
TPO	7173	broad.mit.edu	37	2	1497756	1497756	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr2:1497756C>T	ENST00000345913.4	+	11	2042	c.1951C>T	c.(1951-1953)Ccc>Tcc	p.P651S	TPO_ENST00000382198.1_Missense_Mutation_p.P478S|TPO_ENST00000382201.3_Missense_Mutation_p.P594S|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000349624.3_Missense_Mutation_p.P478S|TPO_ENST00000346956.3_Missense_Mutation_p.P651S|TPO_ENST00000337415.3_Missense_Mutation_p.P651S|TPO_ENST00000329066.4_Missense_Mutation_p.P651S	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	651					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TCGGACAGGGCCCCTGTTTGC	0.567000													16	26					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413628	105413628	+	Silent	SNP	G	G	A			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr14:105413628G>A	ENST00000333244.5	-	7	8279	c.8160C>T	c.(8158-8160)caC>caT	p.H2720H	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2720						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTCGGGAACGTGGCCCTCTG	0.597000													83	96					0	0	1	0	0
ETV1	2115	broad.mit.edu	37	7	14028333	14028333	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr7:14028333C>T	ENST00000405358.4	-	1	165	c.59G>A	c.(58-60)gGg>gAg	p.G20E	ETV1_ENST00000430479.1_Intron|ETV1_ENST00000343495.5_Intron|ETV1_ENST00000403685.1_Intron|ETV1_ENST00000405218.2_Intron|ETV1_ENST00000405192.2_Intron|ETV1_ENST00000242066.5_Intron			P50549	ETV1_HUMAN	ets variant 1	0					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						GCAGACAAACCCAGCCAAAAA	0.388000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								37	68					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				16	31					0	0	1	0	0
ECEL1	9427	broad.mit.edu	37	2	233347145	233347145	+	Silent	SNP	G	G	A			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr2:233347145G>A	ENST00000304546.1	-	12	1989	c.1779C>T	c.(1777-1779)taC>taT	p.Y593Y	ECEL1_ENST00000409941.1_Silent_p.Y591Y	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	593					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		AGTCAGGGTCGTACAGGGTGG	0.617000													48	77					0	0	1	0	0
CYP2D7P1	0	broad.mit.edu	37	22	42538870	42538870	+	RNA	SNP	A	A	C	rs2982057	by1000genomes	TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr22:42538870A>C	ENST00000433992.1	-	0	475				CYP2D7P1_ENST00000358097.4_RNA|CYP2D7P1_ENST00000424775.1_RNA																endometrium(1)	1						CCATAGCGCGACAGGAACACC	0.687000													4	27					0	0	1	0	0
RASSF8	11228	broad.mit.edu	37	12	26220530	26220530	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr12:26220530C>G	ENST00000405154.2	+	4	1221	c.1022C>G	c.(1021-1023)aCt>aGt	p.T341S	RASSF8_ENST00000282884.9_Missense_Mutation_p.T341S|RASSF8_ENST00000542865.1_Missense_Mutation_p.T341S|RASSF8_ENST00000541490.1_Missense_Mutation_p.T341S|RASSF8_ENST00000381352.3_Missense_Mutation_p.T341S	NM_001164748.1	NP_001158220.1	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	341					signal transduction					cervix(2)|endometrium(1)|large_intestine(6)|lung(15)|urinary_tract(1)	25	Colorectal(261;0.0847)					GAGCAGTTGACTAAGGAGTTG	0.433000													3	34					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47805846	47805846	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr21:47805846G>A	ENST00000359568.5	+	17	3519	c.3412G>A	c.(3412-3414)Gca>Aca	p.A1138T	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1138					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					CCGGGAAGGCGCAAACCTCCT	0.612000													5	97					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71346978	71346978	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr4:71346978T>C	ENST00000413702.1	+	4	805	c.517T>C	c.(517-519)Tct>Cct	p.S173P	MUC7_ENST00000304887.5_Missense_Mutation_p.S173P|MUC7_ENST00000456088.1_Missense_Mutation_p.S173P|MUC7_ENST00000514512.1_3'UTR	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	173	Thr-rich.					extracellular region	protein binding	p.S173P(3)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.522000													7	154					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39799059	39799060	+	Frame_Shift_Ins	INS	-	-	G			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr1:39799059_39799060insG	ENST00000564288.1	+	37	7576_7577	c.6799_6800insG	c.(6799-6801)ggafs	p.G2267fs	MACF1_ENST00000476350.1_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000567887.1_Frame_Shift_Ins_p.G2304fs|MACF1_ENST00000372915.3_Frame_Shift_Ins_p.G2272fs|MACF1_ENST00000289893.4_Frame_Shift_Ins_p.G707fs|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000361689.2_Intron			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2272					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGATAGTGGCAGGGAAATTTTT	0.391													12	82	---	---	---	---					
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	GACGGG	-	rs112040677		TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr2:131129929_131129934delGACGGG	ENST00000175756.5	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)cag>ca	p.QTG371del	PTPN18_ENST00000347849.3_In_Frame_Del_p.QTG264del	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	371						cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity	p.T378_G379delTG(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.777													6	11	---	---	---	---					
FBXL8	55336	broad.mit.edu	37	16	67196927	67196929	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr16:67196927_67196929delGCC	ENST00000258200.3	+	3	506_508	c.329_331delGCC	c.(328-333)tgc>t	p.CR110del	FBXL8_ENST00000519917.1_In_Frame_Del_p.CR110del			Q96CD0	FBXL8_HUMAN	F-box and leucine-rich repeat protein 8	110							protein binding			endometrium(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0144)|Epithelial(162;0.0338)|all cancers(182;0.185)		CGCCTGGAGTGCCGCGGAGAAAA	0.714													2	4	---	---	---	---					
hsa-mir-6080	0	broad.mit.edu	37	17	62775108	62775108	+	RNA	DEL	C	C	-			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr17:62775108delC	ENST00000400873.3	-	0	1019					NR_026899.1																						CCACGCGGCGCCCGTCCTTGC	0.701													2	4	---	---	---	---					
CBR3-AS1	0	broad.mit.edu	37	21	37505260	37505260	+	RNA	DEL	A	A	-			TCGA-EM-A4FN-01A-11D-A257-08	TCGA-EM-A4FN-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	add94e55-aefe-4e63-8a5e-142dd824f46d	0c74daf3-b58e-40e5-8058-030dbe42c407	g.chr21:37505260delA	ENST00000413862.1	-	0	366				CBR3-AS1_ENST00000453159.1_RNA	NR_038892.1																						AACCCCAGCCACGTGAAGAGG	0.577													2	4	---	---	---	---					
