Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GIGYF2	26058	broad.mit.edu	37	2	233710457	233710457	+	Silent	SNP	G	G	A			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr2:233710457G>A	ENST00000373566.3	+	27	3584	c.3387G>A	c.(3385-3387)gtG>gtA	p.V1129V	GIGYF2_ENST00000409480.1_Silent_p.V1129V|GIGYF2_ENST00000373563.4_Silent_p.V1107V|GIGYF2_ENST00000409547.1_Silent_p.V1107V|GIGYF2_ENST00000409451.3_Silent_p.V1128V|GIGYF2_ENST00000409196.3_Silent_p.V1101V			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	1107					cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		CTGTAGGTGTGTCTAACCGGC	0.363000													4	75					0	0	0.184627	0	0
CACHD1	57685	broad.mit.edu	37	1	65117914	65117914	+	Silent	SNP	G	G	A			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr1:65117914G>A	ENST00000371073.2	+	10	1461	c.1461G>A	c.(1459-1461)gtG>gtA	p.V487V	CACHD1_ENST00000290039.5_Silent_p.V436V|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	487	Cache 1.				calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GTGTGGACGTGAATCTGGCTT	0.368000													12	72					0	0	0.411799	0	0
FCGBP	8857	broad.mit.edu	37	19	40433640	40433640	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr19:40433640G>A	ENST00000221347.6	-	2	636	c.629C>T	c.(628-630)tCg>tTg	p.S210L		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	210	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTTTGACCCCGAGAGATCCAC	0.542000													9	75					0	0	0.361761	0	0
KMT2C	58508	broad.mit.edu	37	7	151879574	151879574	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr7:151879574G>A	ENST00000355193.2	-	36	5589	c.5371C>T	c.(5371-5373)Cag>Tag	p.Q1791*	KMT2C_ENST00000262189.6_Nonsense_Mutation_p.Q1791*					lysine (K)-specific methyltransferase 2C									p.Q1791*(2)									AGAAGATGCTGAGAACCAAAT	0.468000													15	177					0	0	0.457914	0	0
TRPM3	80036	broad.mit.edu	37	9	73152080	73152080	+	Missense_Mutation	SNP	C	C	T	rs144341800		TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr9:73152080C>T	ENST00000377110.2	-	25	4156	c.3913G>A	c.(3913-3915)Gaa>Aaa	p.E1305K	TRPM3_ENST00000408909.2_Missense_Mutation_p.E1164K|TRPM3_ENST00000360823.2_Missense_Mutation_p.E1167K|TRPM3_ENST00000377106.1_Missense_Mutation_p.E1177K|TRPM3_ENST00000396280.5_Missense_Mutation_p.E1154K|TRPM3_ENST00000396292.4_Missense_Mutation_p.E1177K|TRPM3_ENST00000377111.2_Missense_Mutation_p.E1305K|TRPM3_ENST00000357533.2_Missense_Mutation_p.E1309K|TRPM3_ENST00000396285.1_Missense_Mutation_p.E1164K|TRPM3_ENST00000423814.3_Missense_Mutation_p.E1332K|TRPM3_ENST00000377105.1_Missense_Mutation_p.E1164K|TRPM3_ENST00000358082.3_Missense_Mutation_p.E1167K	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	1330						integral to membrane	calcium channel activity	p.E1309K(1)|p.E1177K(1)		NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GTGTTCCCTTCCTGGCTGTTG	0.567000													23	100					0	0	0.681144	0	0
KCNAB1	7881	broad.mit.edu	37	3	156009858	156009858	+	Silent	SNP	G	G	T	rs138625130		TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr3:156009858G>T	ENST00000302490.8	+	1	1033	c.162G>T	c.(160-162)acG>acT	p.T54T	KCNAB1_ENST00000471742.1_Intron|KCNAB1_ENST00000389636.5_Intron|KCNAB1_ENST00000490337.1_Intron|KCNAB1_ENST00000389634.5_Silent_p.T54T	NM_172159.3	NP_751891.1	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	72						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity	p.T54T(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GGACGTTCACGCCTCAGCATC	0.567000													4	81					1.23904e-05	1.42125e-05	0.184627	1	0
SIRPB1	10326	broad.mit.edu	37	20	1585397	1585397	+	Missense_Mutation	SNP	T	T	C	rs148754551	by1000genomes	TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr20:1585397T>C	ENST00000279477.7	-	3	806	c.742A>G	c.(742-744)Acc>Gcc	p.T248A	RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381605.4_Intron|SIRPB1_ENST00000381603.3_Intron|SIRPB1_ENST00000568365.1_Missense_Mutation_p.T248A	NM_001135844.2	NP_001129316.1	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	248					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.T248A(5)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CCTCGGATGGTCTCAGACAAG	0.627000													5	44					0	0	0.184627	0	0
KMT2C	58508	broad.mit.edu	37	7	151878394	151878394	+	Missense_Mutation	SNP	G	G	C			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr7:151878394G>C	ENST00000355193.2	-	36	6769	c.6551C>G	c.(6550-6552)tCt>tGt	p.S2184C	KMT2C_ENST00000262189.6_Missense_Mutation_p.S2184C					lysine (K)-specific methyltransferase 2C																		AGTTTGTGTAGATGGTCTTGG	0.483000													6	89					0	0	0.278610	0	0
FRAS1	80144	broad.mit.edu	37	4	79207662	79207662	+	Silent	SNP	C	C	T			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr4:79207662C>T	ENST00000264895.6	+	14	1943	c.1503C>T	c.(1501-1503)gaC>gaT	p.D501D	FRAS1_ENST00000264899.6_Silent_p.D501D|FRAS1_ENST00000325942.6_Silent_p.D501D	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	501					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CCTGTGGGGACGGCTTCTACC	0.632000													6	77					0	0	0.217242	0	0
ZGPAT	84619	broad.mit.edu	37	20	62340073	62340073	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr20:62340073C>G	ENST00000328969.5	+	2	268	c.141C>G	c.(139-141)atC>atG	p.I47M	ZGPAT_ENST00000448100.1_Missense_Mutation_p.I47M|ZGPAT_ENST00000355969.6_Missense_Mutation_p.I47M|ZGPAT_ENST00000369967.3_Missense_Mutation_p.I47M|ZGPAT_ENST00000357119.4_Missense_Mutation_p.I47M|ZGPAT_ENST00000490623.1_3'UTR	NM_032527.4	NP_115916.3	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	47					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	14	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					AGGAGCTCATCGAGCTCACCG	0.672000													7	64					0	0	0.307466	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713867	142713867	+	RNA	SNP	C	C	G	rs142097515	by1000genomes	TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr1:142713867C>G	ENST00000369381.2	-	0	738																											TCATTTCTTCCTGATTATGAA	0.303000													3	51					0	0	0.248553	0	0
NDUFB10	4716	broad.mit.edu	37	16	2011570	2011570	+	Silent	SNP	C	C	T			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr16:2011570C>T	ENST00000543683.2	+	3	424	c.342C>T	c.(340-342)aaC>aaT	p.N114N	NDUFB10_ENST00000569148.1_Silent_p.N103N|NDUFB10_ENST00000268668.6_Silent_p.N114N			O96000	NDUBA_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa	114					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			lung(1)|urinary_tract(1)	2					NADH(DB00157)	AAGGACAGAACTACCAGCAGA	0.557000													14	89					0	0	0.457914	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													5	85					0	0	0.217242	0	0
PSME4	23198	broad.mit.edu	37	2	54146345	54146345	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr2:54146345C>A	ENST00000404125.1	-	20	2514	c.2459G>T	c.(2458-2460)tGt>tTt	p.C820F	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	820					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GCCAATTAAACAGTTGTGCAC	0.333000													3	50					0.00024832	0.000269013	0.150653	1	0
KIF1C	10749	broad.mit.edu	37	17	4906130	4906130	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr17:4906130C>T	ENST00000320785.5	+	8	1070	c.713C>T	c.(712-714)tCg>tTg	p.S238L		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	238	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						GGGCTGGACTCGGAGAAGGTG	0.632000													6	56					0	0	0.217242	0	0
KMT2C	58508	broad.mit.edu	37	7	151878929	151878929	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr7:151878929G>A	ENST00000355193.2	-	36	6234	c.6016C>T	c.(6016-6018)Cac>Tac	p.H2006Y	KMT2C_ENST00000262189.6_Missense_Mutation_p.H2006Y					lysine (K)-specific methyltransferase 2C																		TTAGTAAAGTGATCACTGGTT	0.463000													15	201					0	0	0.520397	0	0
ESPNP	0	broad.mit.edu	37	1	17023143	17023143	+	RNA	SNP	C	C	T	rs559507	by1000genomes	TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr1:17023143C>T	ENST00000492551.1	-	0	1720					NR_026567.1																						TGTGGGGCTCCGGACTGGTAA	0.692000													8	25					0	0	0.307466	0	0
NBPF10	100132406	broad.mit.edu	37	1	145368466	145368466	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr1:145368466G>A	ENST00000342960.5	+	84	10479	c.10444G>A	c.(10444-10446)Gaa>Aaa	p.E3482K	NBPF10_ENST00000369338.1_Missense_Mutation_p.E598K|NBPF10_ENST00000369339.2_Missense_Mutation_p.E600K	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3482										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GATGGAAGTGGAAGAGCGTGA	0.468000													30	494					0	0	0.750413	0	0
AIM1	202	broad.mit.edu	37	6	106992466	106992466	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr6:106992466C>T	ENST00000369066.3	+	10	4323	c.3836C>T	c.(3835-3837)cCt>cTt	p.P1279L	AIM1_ENST00000535438.1_Missense_Mutation_p.P98L|AIM1_ENST00000487681.1_3'UTR	NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1279	Beta/gamma crystallin 'Greek key' 6.						sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TATGAGAAACCTGGATTTACC	0.398000													4	69					0	0	0.184627	0	0
TIPIN	54962	broad.mit.edu	37	15	66633685	66633685	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr15:66633685G>A	ENST00000261881.4	-	7	570	c.485C>T	c.(484-486)gCg>gTg	p.A162V	TIPIN_ENST00000367709.4_Missense_Mutation_p.A61V	NM_017858.2	NP_060328.2	Q9BVW5	TIPIN_HUMAN	TIMELESS interacting protein	162					cell division|DNA replication checkpoint|intra-S DNA damage checkpoint|mitosis|positive regulation of cell proliferation|regulation of DNA replication involved in S phase|replication fork protection	cytoplasm|nuclear chromatin	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	7						ATTATTCTCCGCAACTTCATC	0.363000													3	24					0	0	0.115264	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				19	52					0	0	0.575678	0	0
KMT2C	58508	broad.mit.edu	37	7	151879081	151879081	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr7:151879081G>A	ENST00000355193.2	-	36	6082	c.5864C>T	c.(5863-5865)tCt>tTt	p.S1955F	KMT2C_ENST00000262189.6_Missense_Mutation_p.S1955F					lysine (K)-specific methyltransferase 2C																		TGTCGTGGAAGAAGAACATAA	0.463000													12	210					0	0	0.457914	0	0
PLP1	5354	broad.mit.edu	37	X	103042822	103042822	+	Silent	SNP	C	C	T			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chrX:103042822C>T	ENST00000418604.1	+	5	829	c.549C>T	c.(547-549)acC>acT	p.T183T	PLP1_ENST00000466486.1_3'UTR|PLP1_ENST00000303958.2_Silent_p.T183T|PLP1_ENST00000361621.2_Silent_p.T148T	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	183			T -> N (in HLD1).		cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						CCTGGACCACCTGCCAGTCTA	0.527000													33	92					0	0	0.769981	0	0
BOD1L1	259282	broad.mit.edu	37	4	13593582	13593582	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr4:13593582delG	ENST00000040738.5	-	13	8248	c.8113delC	c.(8113-8115)agfs	p.Q2705fs		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2705							DNA binding										GGCTCCCTCTGGAGTTCAGCT	0.308													2	4	---	---	---	---					
RP11-584P21.2	0	broad.mit.edu	37	4	68311853	68311855	+	RNA	DEL	GAG	GAG	-			TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr4:68311853_68311855delGAG	ENST00000502400.1	-	0	34																											TCTCTATGGCGAGGAGGAGGAGG	0.547													2	4	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	-	G	rs113730440		TCGA-ET-A3DU-01A-11D-A19J-08	TCGA-ET-A3DU-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	70168ed4-c985-46b2-8c9a-c0510fef5e77	f2a70c64-a751-4ecd-9361-59710dcc20d3	g.chr17:26684394_26684395insG	ENST00000540200.1	-	1	78		c.e1+1		POLDIP2_ENST00000003607.4_5'UTR	NM_015584.3	NP_056399.1	Q9Y2S7	PDIP2_HUMAN	polymerase (DNA-directed), delta interacting protein 2							mitochondrial nucleoid|nucleus						all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													4	5	---	---	---	---					
