Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SEZ6	124925	broad.mit.edu	37	17	27283247	27283247	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr17:27283247C>G	ENST00000317338.12	-	16	3310	c.2882G>C	c.(2881-2883)cGc>cCc	p.R961P	SEZ6_ENST00000442608.3_Missense_Mutation_p.R948P|PIPOX_ENST00000583215.1_Intron|SEZ6_ENST00000360295.9_Missense_Mutation_p.R961P|SEZ6_ENST00000335960.6_Silent_p.P493P			Q53EL9	SEZ6_HUMAN	seizure related 6 homolog (mouse)	961						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	29	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			ggggcgggggcggggCAGCTG	0.582000													4	1					0	0	1	0	0
BTN2A3P	0	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													5	158					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127737869	127737869	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr10:127737869G>A	ENST00000368679.4	-	16	2188	c.1879C>T	c.(1879-1881)Ccg>Tcg	p.P627S	ADAM12_ENST00000368676.4_Missense_Mutation_p.P627S	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	627	Cys-rich.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CCTGGGTCCGGCATGTCATCG	0.527000													5	220					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr11:533874T>C	ENST00000417302.1	-	3	369	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_ENST00000468682.2_5'UTR|HRAS_ENST00000397596.2_Missense_Mutation_p.Q61R|HRAS_ENST00000451590.1_Missense_Mutation_p.Q61R|HRAS_ENST00000311189.7_Missense_Mutation_p.Q61R|HRAS_ENST00000397594.1_Missense_Mutation_p.Q61R	NM_176795.3	NP_789765.1	P01112	RASH_HUMAN	Harvey rat sarcoma viral oncogene homolog	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(136)|p.Q61L(117)|p.Q61P(3)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			42	82					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													4	49					0.000602214	0.000656961	1	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125299250	125299250	+	Missense_Mutation	SNP	A	A	T			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chrX:125299250A>T	ENST00000538699.1	-	2	738	c.658T>A	c.(658-660)Tgg>Agg	p.W220R	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.W220R	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	220										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						TCCATCCGCCACAGAGCCACG	0.632000													20	55					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154197713	154197713	+	Missense_Mutation	SNP	C	C	T	rs137852403		TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chrX:154197713C>T	ENST00000360256.4	-	7	1102	c.902G>A	c.(901-903)cGc>cAc	p.R301H		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	301	F5/8 type A 1.|Plastocyanin-like 2.		R -> C (in HEMA; severe/mild).|R -> H (in HEMA; severe; dbSNP:rs28935216).|R -> L (in HEMA; severe).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GGACGCCTGGCGATGGTTCCT	0.458000													12	147					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17758148	17758148	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr19:17758148G>A	ENST00000428389.2	-	18	2233	c.2234C>T	c.(2233-2235)aCg>aTg	p.T745M	UNC13A_ENST00000252773.7_Missense_Mutation_p.T657M|UNC13A_ENST00000552293.1_Missense_Mutation_p.T657M|UNC13A_ENST00000551649.1_Missense_Mutation_p.T657M|UNC13A_ENST00000550896.1_Missense_Mutation_p.T655M|UNC13A_ENST00000519716.2_Missense_Mutation_p.T657M			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	657	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CATCTGCTGCGTGTGCGCCGT	0.622000													6	15					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43411861	43411861	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr21:43411861G>A	ENST00000310826.5	-	3	2527	c.2344C>T	c.(2344-2346)Cgc>Tgc	p.R782C	ZBTB21_ENST00000398499.1_Missense_Mutation_p.R782C|ZBTB21_ENST00000465968.1_5'UTR|ZBTB21_ENST00000398511.3_Missense_Mutation_p.R782C|ZBTB21_ENST00000398505.3_Missense_Mutation_p.R581C	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		TTGAAGGTGCGCATGCACTCG	0.517000													5	226					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96019417	96019417	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr9:96019417C>T	ENST00000297954.4	+	10	2378	c.2378C>T	c.(2377-2379)cCg>cTg	p.P793L	WNK2_ENST00000395477.2_Missense_Mutation_p.P793L|WNK2_ENST00000427277.2_Missense_Mutation_p.P405L|WNK2_ENST00000395475.2_Missense_Mutation_p.P727L|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.P405L			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	793					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CAAGTCCCTCCGCAGGTAATT	0.662000													14	24					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000389561.2_Silent_p.Q2725Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													5	54					0	0	1	0	0
LRRC39	127495	broad.mit.edu	37	1	100614603	100614603	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr1:100614603C>A	ENST00000370137.1	-	10	1201	c.1003G>T	c.(1003-1005)Gga>Tga	p.G335*	TRMT13_ENST00000370141.2_3'UTR|LRRC39_ENST00000342895.3_Nonsense_Mutation_p.G335*|LRRC39_ENST00000370138.1_3'UTR	NM_001256386.1|NM_144620.3	NP_001243315.1|NP_653221.1	Q96DD0	LRC39_HUMAN	leucine rich repeat containing 39	335										endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	13		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0826)|all cancers(265;0.135)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		TTATATTATCCATCCGTATTT	0.318000													3	38					1	1	1	1	0
PMM2	5373	broad.mit.edu	37	16	8906904	8906904	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr16:8906904C>T	ENST00000268261.4	+	7	646	c.580C>T	c.(580-582)Cga>Tga	p.R194*	PMM2_ENST00000569958.1_Nonsense_Mutation_p.R103*|PMM2_ENST00000566983.1_Nonsense_Mutation_p.R167*|PMM2_ENST00000539622.1_Nonsense_Mutation_p.R111*|PMM2_ENST00000537352.1_Nonsense_Mutation_p.R69*	NM_000303.2	NP_000294.1	O15305	PMM2_HUMAN	phosphomannomutase 2	194					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			breast(3)|cervix(1)|endometrium(2)|large_intestine(1)|ovary(1)|skin(1)	9						ATACTGTCTGCGACATGTGGA	0.453000													6	149					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20796598	20796598	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr22:20796598C>T	ENST00000328879.4	-	7	1823	c.1667G>A	c.(1666-1668)cGc>cAc	p.R556H	KLHL22_ENST00000440659.2_Missense_Mutation_p.R413H	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	556					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCGGCTGCCGCGGTTGTGTGA	0.612000													27	14					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113147089	113147089	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr2:113147089G>A	ENST00000302558.3	-	20	3624	c.3433C>T	c.(3433-3435)Cgg>Tgg	p.R1145W	RGPD8_ENST00000409750.1_Missense_Mutation_p.R1005W	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8											endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GCTGCCAACCGCTCTAGTTTG	0.458000													4	226					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													4	49					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													4	48					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169214990	169214990	+	Missense_Mutation	SNP	C	C	T	rs146995893		TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr4:169214990C>T	ENST00000393743.3	-	7	1121	c.830G>A	c.(829-831)cGc>cAc	p.R277H		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	277							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TCCTAAAAAGCGATGGTACAT	0.408000													11	117					0	0	1	0	0
C6orf223	221416	broad.mit.edu	37	6	43970503	43970504	+	In_Frame_Ins	INS	-	-	GCG	rs72369323		TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr6:43970503_43970504insGCG	ENST00000336600.5	+	4	389_390	c.369_370insGCG	c.(367-372)cgcggc>cgGCGcggc	p.123_124insR	C6orf223_ENST00000439969.2_3'UTR|C6orf223_ENST00000448947.2_3'UTR|RP5-1120P11.1_ENST00000607590.1_RNA|RP5-1120P11.1_ENST00000422059.1_RNA	NM_001171992.1|NM_153246.4	NP_001165463.1|NP_694978.2	Q8N319	CF223_HUMAN	chromosome 6 open reading frame 223	123										central_nervous_system(1)|lung(2)|pancreas(1)|prostate(1)|urinary_tract(1)	6	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			CGGTAGAGCGCgcggcggcggc	0.777													4	9	---	---	---	---					
TMEM184A	202915	broad.mit.edu	37	7	1586662	1586663	+	In_Frame_Ins	INS	-	-	GCC	rs3837151	by1000genomes	TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr7:1586662_1586663insGCC	ENST00000297477.5	-	9	1483_1484	c.1167_1168insGGC	c.(1165-1170)ccgcgg>ccGGCgcgg	p.389_390PR>PAR		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	389						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		GAGCCGCCGCTGGGGTGGGTGC	0.703													12	39	---	---	---	---					
DLX6	1750	broad.mit.edu	37	7	96635420	96635421	+	In_Frame_Ins	INS	-	-	GCC			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr7:96635420_96635421insGCC	ENST00000518156.2	+	1	561_562	c.131_132insGCC	c.(130-132)ccc>cGCCcc	p.43_44insR	DLX6-AS1_ENST00000458352.2_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000430027.2_RNA|DLX6-AS1_ENST00000437541.1_RNA|DLX6_ENST00000007660.5_Intron|DLX6-AS1_ENST00000605417.1_RNA			P56179	DLX6_HUMAN	distal-less homeobox 6	0					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					caacagcaacagccgccgccgc	0.698													3	5	---	---	---	---					
PTPRB	0	broad.mit.edu	37	12	70954544	70954545	+	Frame_Shift_Ins	INS	-	-	C			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chr12:70954544_70954545insC	ENST00000334414.6	-	17	4382_4383	c.4338_4339insG	c.(4336-4341)cgttcafs	p.S1447fs	PTPRB_ENST00000550358.1_Frame_Shift_Ins_p.S1359fs|PTPRB_ENST00000538708.1_Frame_Shift_Ins_p.S1139fs|PTPRB_ENST00000451516.2_Frame_Shift_Ins_p.S1139fs|PTPRB_ENST00000551525.1_Frame_Shift_Ins_p.S1446fs|PTPRB_ENST00000261266.5_Frame_Shift_Ins_p.S1229fs|PTPRB_ENST00000550857.1_Frame_Shift_Ins_p.S1139fs	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1229					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGGCCTTGAAACCGCCACTCCG	0.490													8	40	---	---	---	---					
BCORL1	63035	broad.mit.edu	37	X	129171350	129171351	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-ET-A40P-01A-11D-A23M-08	TCGA-ET-A40P-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fa3cb4c-2255-4346-9830-761b39c929ac	a4bb0a0e-f781-42dd-b6fe-eb216ef56842	g.chrX:129171350_129171351delTC	ENST00000540052.1	+	8	4358_4359	c.4314_4315delTC	c.(4312-4317)gttcfs	p.VL1438fs	BCORL1_ENST00000359304.2_Frame_Shift_Del_p.VL1308fs|BCORL1_ENST00000303743.5_Frame_Shift_Del_p.VL1512fs|BCORL1_ENST00000218147.7_Frame_Shift_Del_p.VL1438fs	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1438					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						AGGATGTTGTTCTCTACTGCCT	0.500													36	62	---	---	---	---					
