Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CEP350	9857	broad.mit.edu	37	1	180022212	180022212	+	Missense_Mutation	SNP	C	C	A			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr1:180022212C>A	ENST00000367607.3	+	23	5318	c.4900C>A	c.(4900-4902)Cgc>Agc	p.R1634S		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1634						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						AGAGAGTCACCGCAGATTTAA	0.378000													3	15					0.115264	0.115264	1	1	0
PWP2	5822	broad.mit.edu	37	21	45542224	45542224	+	Silent	SNP	C	C	T			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr21:45542224C>T	ENST00000291576.7	+	14	1930	c.1803C>T	c.(1801-1803)caC>caT	p.H601H		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	601						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CAGCCAAGCACGCGGCCAAGG	0.587000													18	25					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000583708.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													4	69					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46915066	46915066	+	Silent	SNP	A	A	G			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr19:46915066A>G	ENST00000307522.3	-	1	1775	c.1002T>C	c.(1000-1002)aaT>aaC	p.N334N		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	334						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CTTCCCTCTGATTATCTGCAG	0.597000													5	159					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73830422	73830422	+	Missense_Mutation	SNP	C	C	T			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr17:73830422C>T	ENST00000207549.4	-	23	2661	c.2282G>A	c.(2281-2283)cGc>cAc	p.R761H	UNC13D_ENST00000412096.2_Missense_Mutation_p.R761H	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	761					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGCCAGGGTGCGGACGCCAGT	0.682000									Familial Hemophagocytic Lymphohistiocytosis				3	10					0	0	1	0	0
TBX2	6909	broad.mit.edu	37	17	59485502	59485502	+	Missense_Mutation	SNP	G	G	A			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr17:59485502G>A	ENST00000240328.3	+	7	2055	c.1774G>A	c.(1774-1776)Gcc>Acc	p.A592T	RP11-332H18.4_ENST00000592009.1_RNA	NM_005994.3	NP_005985.3	Q13207	TBX2_HUMAN	T-box 2	592	Ala-rich.				cell aging|positive regulation of cell proliferation		sequence-specific DNA binding			endometrium(1)|lung(7)|ovary(1)	9						ggctttgcccgccactagtgc	0.672000													3	15					0	0	1	0	0
EEF1DP3	0	broad.mit.edu	37	13	32527237	32527237	+	RNA	SNP	G	G	A			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr13:32527237G>A	ENST00000428783.1	+	0	937																											CCGCGCTGGTGGCCAAGTCCT	0.627000													3	19					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19525140	19525140	+	Silent	SNP	G	G	A			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr1:19525140G>A	ENST00000375267.2	-	5	546	c.543C>T	c.(541-543)agC>agT	p.S181S	UBR4_ENST00000375226.2_Silent_p.S181S|UBR4_ENST00000375254.3_Silent_p.S181S|UBR4_ENST00000375217.2_Silent_p.S181S			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	181					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding	p.V180fs*18(1)		breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCAACTCAGGGCTTACTGGTG	0.443000													20	28					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50098775	50098775	+	Missense_Mutation	SNP	G	G	T			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr19:50098775G>T	ENST00000418929.2	+	4	1195	c.1183G>T	c.(1183-1185)Ggt>Tgt	p.G395C		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	135	Pro-rich.						DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGGCAAAGGTGGTTATGGAGC	0.701000													3	9					6.4e-05	6.93333e-05	1	1	0
TRIP11	9321	broad.mit.edu	37	14	92484052	92484052	+	Missense_Mutation	SNP	T	T	C			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr14:92484052T>C	ENST00000267622.4	-	5	1004	c.631A>G	c.(631-633)Ata>Gta	p.I211V		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	211					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		AGTTTACATATTTCACTTTGA	0.299000			T	PDGFRB	AML								7	8					0	0	1	0	0
RASGEF1B	153020	broad.mit.edu	37	4	82369389	82369389	+	Missense_Mutation	SNP	T	T	C			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr4:82369389T>C	ENST00000509081.1	-	5	706	c.485A>G	c.(484-486)aAg>aGg	p.K162R	RASGEF1B_ENST00000264400.2_Missense_Mutation_p.K163R|RASGEF1B_ENST00000335927.7_Missense_Mutation_p.K121R			Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	163	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			endometrium(2)|kidney(5)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	26						CGCAGCAAGCTTGCGGATCAG	0.483000													5	93					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	17982398	17982398	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr1:17982398delG	ENST00000361221.3	+	24	2665	c.2506delG	c.(2506-2508)ggfs	p.G837fs	ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000375415.1_Frame_Shift_Del_p.G798fs|ARHGEF10L_ENST00000375408.3_Frame_Shift_Del_p.G610fs|ARHGEF10L_ENST00000434513.1_Frame_Shift_Del_p.G832fs|ARHGEF10L_ENST00000167825.4_Frame_Shift_Del_p.G540fs|ARHGEF10L_ENST00000452522.1_Frame_Shift_Del_p.G798fs	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	837					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GGAAGGCGCAGGGGGCCAGGT	0.642													2	4	---	---	---	---					
ALMS1P	0	broad.mit.edu	37	2	73902182	73902183	+	RNA	INS	-	-	A			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr2:73902182_73902183insA	ENST00000450720.1	+	0	985					NR_003683.2																						TTATGGCACTGAAAAAAAAAGT	0.347													2	4	---	---	---	---					
KIF5C	3800	broad.mit.edu	37	2	149793841	149793841	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr2:149793841delT	ENST00000435030.1	+	4	703	c.335delT	c.(334-336)atfs	p.I112fs	KIF5C_ENST00000414838.2_Frame_Shift_Del_p.I17fs			O60282	KIF5C_HUMAN	kinesin family member 5C	112	Kinesin-motor.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		ATCCCACGAATTGCCCATGAT	0.493													2	4	---	---	---	---					
MLXIPL	51085	broad.mit.edu	37	7	73020366	73020366	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr7:73020366delC	ENST00000313375.3	-	6	741	c.694delG	c.(694-696)acfs	p.D232fs	MLXIPL_ENST00000395189.1_Intron|MLXIPL_ENST00000354613.1_Frame_Shift_Del_p.D232fs|MLXIPL_ENST00000434326.1_Intron|MLXIPL_ENST00000429400.2_Frame_Shift_Del_p.D232fs|MLXIPL_ENST00000414749.2_Frame_Shift_Del_p.D232fs	NM_032951.2|NM_032953.2	NP_116569.1|NP_116571.1	Q9NP71	WBS14_HUMAN	MLX interacting protein-like	232					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			cervix(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13		Lung NSC(55;0.0659)|all_lung(88;0.152)				TCCTCTGGGTCCCCCAGCAGC	0.632													2	4	---	---	---	---					
FBXO7	25793	broad.mit.edu	37	22	32889228	32889228	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FK-A4UB-01A-11D-A257-08	TCGA-FK-A4UB-10A-01D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	27a87b73-18e7-4a46-919a-b8d2c61b7e68	ec0b1542-f2d7-40f1-8adb-c3d1e579be03	g.chr22:32889228delC	ENST00000266087.7	+	7	1431	c.1104delC	c.(1102-1104)gafs	p.D368fs	FBXO7_ENST00000382058.3_Frame_Shift_Del_p.D289fs|FBXO7_ENST00000397426.1_Frame_Shift_Del_p.D254fs	NM_012179.3	NP_036311.3	Q9Y3I1	FBX7_HUMAN	F-box protein 7	368	F-box.				cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CTTCAAATGACCCACTCCTGT	0.438													23	52	---	---	---	---					
