Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
EFEMP2	30008	broad.mit.edu	37	11	65636030	65636030	+	Silent	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr11:65636030G>A	ENST00000307998.6	-	8	1028	c.798C>T	c.(796-798)tcC>tcT	p.S266S	EFEMP2_ENST00000528176.1_Silent_p.S266S	NM_016938.4	NP_058634.4	O95967	FBLN4_HUMAN	EGF containing fibulin-like extracellular matrix protein 2	266	EGF-like 5; calcium-binding (Potential).				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21				READ - Rectum adenocarcinoma(159;0.169)		GGCAGTGGCAGGAGAAACGGC	0.622000													3	64					0	0	0.115264	0	0
ZNF521	25925	broad.mit.edu	37	18	22805082	22805082	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr18:22805082C>T	ENST00000361524.3	-	4	2948	c.2800G>A	c.(2800-2802)Gtg>Atg	p.V934M	ZNF521_ENST00000584787.1_Missense_Mutation_p.V714M|ZNF521_ENST00000538137.2_Missense_Mutation_p.V934M	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	934					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CGAGAGCACACGTTGCACTTG	0.507000			T	PAX5	ALL								22	106					0	0	0.667858	0	0
DLGAP4	22839	broad.mit.edu	37	20	35125295	35125295	+	Silent	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr20:35125295G>A	ENST00000373913.3	+	8	2316	c.1836G>A	c.(1834-1836)ctG>ctA	p.L612L	DLGAP4_ENST00000475894.1_3'UTR|DLGAP4_ENST00000340491.4_Silent_p.L73L|DLGAP4_ENST00000401952.2_Silent_p.L612L|DLGAP4_ENST00000339266.5_Silent_p.L612L|DLGAP4_ENST00000373907.2_Silent_p.L612L			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	612					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CGGACAGCCTGGACAGCAGTA	0.632000													3	96					0	0	0.115264	0	0
GALNT12	79695	broad.mit.edu	37	9	101597558	101597558	+	Silent	SNP	T	T	C			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr9:101597558T>C	ENST00000375011.3	+	5	945	c.945T>C	c.(943-945)ttT>ttC	p.F315F		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	315	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				GTGGGCTGTTTGCTGTGAGTA	0.393000													75	76					0	0	0.870114	0	0
ITGA8	8516	broad.mit.edu	37	10	15655758	15655758	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr10:15655758G>A	ENST00000378076.3	-	15	1807	c.1454C>T	c.(1453-1455)cCg>cTg	p.P485L		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	485					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						AGTCACAACCGGTCTTGCTCT	0.463000													3	102					0	0	0.115264	0	0
ABCA1	19	broad.mit.edu	37	9	107562200	107562200	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr9:107562200G>A	ENST00000374736.3	-	36	5237	c.4843C>T	c.(4843-4845)Cgg>Tgg	p.R1615W		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	1615			R -> Q (associated with reduced plasma HDL cholesterol).		Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGGTTGGCCCGGAGAATGGCA	0.468000													3	121					0	0	0.115264	0	0
GBP2	2634	broad.mit.edu	37	1	89579760	89579760	+	Missense_Mutation	SNP	A	A	G			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr1:89579760A>G	ENST00000370466.3	-	7	1356	c.1088T>C	c.(1087-1089)aTt>aCt	p.I363T	GBP2_ENST00000463660.1_5'UTR	NM_004120.3	NP_004111.2	P32456	GBP2_HUMAN	guanylate binding protein 2, interferon-inducible	363					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(1)	20		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		GAAGACTTCAATGGCCTCTCT	0.493000													42	108					0	0	0.870114	0	0
WDR59	79726	broad.mit.edu	37	16	74990380	74990380	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr16:74990380G>A	ENST00000262144.6	-	3	363	c.233C>T	c.(232-234)gCg>gTg	p.A78V	WDR59_ENST00000562331.1_5'UTR	NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	78										breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						CACCGAAGCCGCAAAATAGTG	0.488000													3	78					0	0	0.115264	0	0
GTPBP1	9567	broad.mit.edu	37	22	39112749	39112749	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr22:39112749G>A	ENST00000216044.5	+	4	811	c.578G>A	c.(577-579)cGc>cAc	p.R193H		NM_004286.4	NP_004277.2	O00178	GTPB1_HUMAN	GTP binding protein 1	193					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity	p.R193H(1)		endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	18	Melanoma(58;0.04)					GGCTTTGCCCGCCAGAAACTC	0.557000													3	55					0	0	0.115264	0	0
VDAC1	7416	broad.mit.edu	37	5	133311612	133311612	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr5:133311612G>A	ENST00000265333.3	-	7	896	c.652C>T	c.(652-654)Cgc>Tgc	p.R218C	VDAC1_ENST00000395044.3_Missense_Mutation_p.R218C|VDAC1_ENST00000395047.2_Missense_Mutation_p.R218C	NM_003374.2	NP_003365.1	P21796	VDAC1_HUMAN	voltage-dependent anion channel 1	218					apoptosis|interspecies interaction between organisms	mitochondrial nucleoid|mitochondrial outer membrane|plasma membrane|pore complex	porin activity|protein binding|voltage-gated anion channel activity			endometrium(1)|large_intestine(1)|lung(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)		Dihydroxyaluminium(DB01375)	ATTCCGAAGCGCGTGTTACTG	0.522000													56	215					0	0	0.870114	0	0
AP4M1	9179	broad.mit.edu	37	7	99704048	99704048	+	Missense_Mutation	SNP	C	C	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr7:99704048C>A	ENST00000429084.1	+	14	1227	c.1069C>A	c.(1069-1071)Cca>Aca	p.P357T	AP4M1_ENST00000422582.1_Missense_Mutation_p.P222T|AP4M1_ENST00000359593.4_Missense_Mutation_p.P350T|AP4M1_ENST00000421755.1_Missense_Mutation_p.P350T			O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	350	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCTGAGCAGCCCAGAGCAGAA	0.607000													3	80					0.115264	0.133855	0.115264	1	0
DAAM1	23002	broad.mit.edu	37	14	59797945	59797945	+	Missense_Mutation	SNP	A	A	G			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr14:59797945A>G	ENST00000395125.1	+	13	1602	c.1579A>G	c.(1579-1581)Atc>Gtc	p.I527V	DAAM1_ENST00000360909.3_Missense_Mutation_p.I527V|DAAM1_ENST00000351081.1_Missense_Mutation_p.I527V	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	527					actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CTGTGCTTCAATCCCAGGTGG	0.502000													17	179					0	0	0.500413	0	0
ZW10	9183	broad.mit.edu	37	11	113631247	113631247	+	Missense_Mutation	SNP	C	C	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr11:113631247C>A	ENST00000200135.3	-	4	552	c.408G>T	c.(406-408)caG>caT	p.Q136H		NM_004724.3	NP_004715.1	O43264	ZW10_HUMAN	zw10 kinetochore protein	136	Interaction with RINT1.				cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	18		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		CTTCCAGACGCTGAGCACCAG	0.323000													81	223					7.0969e-38	8.80995e-38	0.870114	1	0
TCHP	84260	broad.mit.edu	37	12	110353299	110353299	+	Missense_Mutation	SNP	C	C	G			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr12:110353299C>G	ENST00000312777.5	+	12	1626	c.1412C>G	c.(1411-1413)gCc>gGc	p.A471G	TCHP_ENST00000405876.4_Missense_Mutation_p.A471G	NM_032300.4	NP_115676.1	Q9BT92	TCHP_HUMAN	trichoplein, keratin filament binding	471	Glu-rich.|Interaction with keratin proteins.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|skin(2)	22						CTCTCAGATGCCCTGCTGCAG	0.637000													25	21					0	0	0.729181	0	0
RBL2	5934	broad.mit.edu	37	16	53504454	53504454	+	Missense_Mutation	SNP	C	C	G			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr16:53504454C>G	ENST00000262133.6	+	16	2542	c.2405C>G	c.(2404-2406)cCt>cGt	p.P802R	RBL2_ENST00000544545.1_Intron|RBL2_ENST00000379935.4_3'UTR	NM_005611.3	NP_005602.3	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	802	Pocket; binds E1A.|Spacer.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						TTGCAAGTCCCTGGTCAAGTG	0.552000													5	105					0	0	0.184627	0	0
RUNDC1	146923	broad.mit.edu	37	17	41141502	41141502	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr17:41141502G>T	ENST00000361677.1	+	3	814	c.802G>T	c.(802-804)Gag>Tag	p.E268*		NM_173079.2	NP_775102.2	Q96C34	RUND1_HUMAN	RUN domain containing 1	268										breast(1)|large_intestine(2)|lung(4)|prostate(1)	8		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		ACAGTTGGTTGAGCAACTGAA	0.493000													28	85					2.09667e-21	2.516e-21	0.788014	1	0
ADPRH	141	broad.mit.edu	37	3	119305412	119305412	+	Silent	SNP	A	A	G			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr3:119305412A>G	ENST00000478399.1	+	3	1984	c.579A>G	c.(577-579)aaA>aaG	p.K193K	ADPRH_ENST00000357003.3_Silent_p.K193K|ADPRH_ENST00000478927.1_Silent_p.K193K|ADPRH_ENST00000465513.1_Silent_p.K193K|ADPRH_ENST00000471850.1_3'UTR			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	193					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		AGTGGGGAAAAGGACTGATGG	0.512000													3	107					0	0	0.115264	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	36					0	0	0.150653	0	0
EFCAB1	79645	broad.mit.edu	37	8	49643961	49643961	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr8:49643961G>A	ENST00000262103.3	-	2	240	c.160C>T	c.(160-162)Cga>Tga	p.R54*	EFCAB1_ENST00000523092.1_Intron|EFCAB1_ENST00000521002.1_Intron|EFCAB1_ENST00000433756.1_Intron	NM_024593.3	NP_078869.1	Q9HAE3	EFCB1_HUMAN	EF-hand calcium binding domain 1	54							calcium ion binding			endometrium(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(2)	14		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)				AGGATGTTTCGAAATGCATTA	0.393000													29	88					0	0	0.740014	0	0
ROBO2	6092	broad.mit.edu	37	3	77623657	77623657	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr3:77623657G>A	ENST00000461745.1	+	14	2879	c.1979G>A	c.(1978-1980)cGc>cAc	p.R660H	ROBO2_ENST00000487694.3_Missense_Mutation_p.R676H|ROBO2_ENST00000332191.8_Missense_Mutation_p.R660H	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	660	Fibronectin type-III 2.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAGGTTGATCGCCAACCCCAG	0.423000													24	48					0	0	0.706142	0	0
HOOK3	84376	broad.mit.edu	37	8	42873627	42873627	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr8:42873627G>A	ENST00000307602.4	+	22	2343	c.2143G>A	c.(2143-2145)Gcc>Acc	p.A715T	RP11-598P20.5_ENST00000534420.1_Missense_Mutation_p.A21T	NM_032410.3	NP_115786.1	Q86VS8	HOOK3_HUMAN	hook microtubule-tethering protein 3	715	Required for association with Golgi.|Required for interaction with MSR1.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	31	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			CGTGCAGCCGGCCACAGCAAG	0.537000			T	RET	papillary thyroid								4	129					0	0	0.184627	0	0
SLC6A10P	0	broad.mit.edu	37	16	32890622	32890622	+	RNA	SNP	T	T	G			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr16:32890622T>G	ENST00000330048.5	-	0	3176					NR_003083.2																						CGTTGGTGTTTTTGTAGACCA	0.617000													4	50					0	0	0.248553	0	0
CNNM1	26507	broad.mit.edu	37	10	101120670	101120670	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr10:101120670C>T	ENST00000356713.4	+	3	2085	c.1796C>T	c.(1795-1797)aCg>aTg	p.T599M	CNNM1_ENST00000446890.1_Missense_Mutation_p.T528M|CNNM1_ENST00000370534.4_Missense_Mutation_p.T234M|CNNM1_ENST00000370528.3_Missense_Mutation_p.T528M	NM_020348.2	NP_065081.2	Q9NRU3	CNNM1_HUMAN	cyclin M1	599					ion transport	integral to membrane|plasma membrane				NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(5)|ovary(1)|prostate(1)|skin(1)	25		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		CTTTCGGACACGGAGATGCGG	0.542000													4	121					0	0	0.150653	0	0
PHKA1	5255	broad.mit.edu	37	X	71864258	71864258	+	Silent	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chrX:71864258G>A	ENST00000373545.3	-	14	1851	c.1413C>T	c.(1411-1413)atC>atT	p.I471I	PHKA1_ENST00000541944.1_Silent_p.I471I|PHKA1_ENST00000373539.3_Silent_p.I471I|PHKA1_ENST00000373542.4_Silent_p.I471I|PHKA1_ENST00000339490.3_Silent_p.I471I			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	471					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					GTTGTACTCTGATGGGGTATA	0.433000													18	51					0	0	0.575678	0	0
DMC1	11144	broad.mit.edu	37	22	38951410	38951410	+	Silent	SNP	A	A	G			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr22:38951410A>G	ENST00000216024.2	-	6	607	c.331T>C	c.(331-333)Tta>Cta	p.L111L	DMC1_ENST00000428462.2_Silent_p.L111L	NM_007068.2	NP_008999.2	Q14565	DMC1_HUMAN	DNA meiotic recombinase 1	111					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11	Melanoma(58;0.0286)					CCTCCTAGTAACTTACTGGAA	0.303000								Homologous recombination					4	106					0	0	0.184627	0	0
FOXP2	93986	broad.mit.edu	37	7	114270000	114270000	+	Silent	SNP	G	G	A			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr7:114270000G>A	ENST00000393500.3	+	11	1132	c.312G>A	c.(310-312)caG>caA	p.Q104Q	FOXP2_ENST00000393489.3_Silent_p.Q87Q|FOXP2_ENST00000360232.4_Silent_p.Q179Q|FOXP2_ENST00000408937.3_Silent_p.Q204Q|FOXP2_ENST00000378237.3_Silent_p.Q179Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000393491.3_Silent_p.Q87Q|FOXP2_ENST00000403559.4_Silent_p.Q196Q|FOXP2_ENST00000390668.3_Silent_p.Q203Q|FOXP2_ENST00000393494.2_Silent_p.Q179Q|FOXP2_ENST00000393498.2_Silent_p.Q159Q|FOXP2_ENST00000350908.4_Silent_p.Q179Q			O15409	FOXP2_HUMAN	forkhead box P2	179	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q204Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcaacaacagcagcagcagc	0.498000													3	73					0	0	0.115264	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142699941	142699942	+	RNA	DEL	TA	TA	-			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr1:142699941_142699942delTA	ENST00000369381.2	-	0	2077																											GAGGAAACACtatatatatata	0.248													4	3	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12046124	12046126	+	RNA	DEL	AGC	AGC	-	rs76272937		TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr3:12046124_12046126delAGC	ENST00000432424.2	+	0	245_247							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						AGCCCCAGCAAGCGCCGAcgccg	0.764													3	5	---	---	---	---					
RP11-377D9.3	0	broad.mit.edu	37	12	13174142	13174147	+	RNA	DEL	AACAAC	AACAAC	-	rs113537246		TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr12:13174142_13174147delAACAAC	ENST00000543321.1	+	0	1025																											ctgtctcaaaaacaacaacaacaaca	0.553													3	6	---	---	---	---					
R3HDM2	22864	broad.mit.edu	37	12	57674205	57674207	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr12:57674205_57674207delTGC	ENST00000402412.1	-	14	1668_1670	c.1278_1280delGCA	c.(1276-1281)caa>ca	p.QQ426del	R3HDM2_ENST00000347140.3_In_Frame_Del_p.QQ412del|R3HDM2_ENST00000413953.2_In_Frame_Del_p.QQ139del|RP11-123K3.4_ENST00000548184.1_RNA|R3HDM2_ENST00000393811.2_In_Frame_Del_p.QQ139del|R3HDM2_ENST00000441731.2_In_Frame_Del_p.QQ73del|R3HDM2_ENST00000358907.2_In_Frame_Del_p.QQ412del|R3HDM2_ENST00000403821.2_In_Frame_Del_p.QQ412del			Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	412	Gln-rich.					nucleus	nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	22						AGCAGGAAGTtgctgctgctgct	0.576													11	172	---	---	---	---					
SAMD15	161394	broad.mit.edu	37	14	77845094	77845094	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr14:77845094delA	ENST00000216471.4	+	1	1619	c.1333delA	c.(1333-1335)aafs	p.K445fs	SAMD15_ENST00000533095.2_Intron	NM_001010860.1	NP_001010860.1	Q9P1V8	SAM15_HUMAN	sterile alpha motif domain containing 15	445										breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CCGTGAGCCTAAAAGAGGAAA	0.383													35	40	---	---	---	---					
C20orf85	128602	broad.mit.edu	37	20	56735727	56735727	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FY-A3I5-01B-11D-A21Z-08	TCGA-FY-A3I5-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2ede8763-643f-4e29-ba92-60bc5be02a3e	f61f065c-bf04-454a-a292-a5178665ac29	g.chr20:56735727delC	ENST00000371168.3	+	4	324	c.263delC	c.(262-264)tcfs	p.S88fs		NM_178456.2	NP_848551.1	Q9H1P6	CT085_HUMAN	chromosome 20 open reading frame 85	88										kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	13	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			GTCTTTCCATCCCCCCCAGTC	0.582													7	82	---	---	---	---					
