Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IGFN1	91156	broad.mit.edu	37	1	201184678	201184678	+	Missense_Mutation	SNP	A	A	G			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr1:201184678A>G	ENST00000335211.4	+	15	9137	c.9007A>G	c.(9007-9009)Att>Gtt	p.I3003V	IGFN1_ENST00000451870.2_Missense_Mutation_p.I546V|IGFN1_ENST00000295591.8_Missense_Mutation_p.I163V	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TTCCCCTACCATTGCTCCAGA	0.522000													49	69					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169642009	169642009	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr6:169642009C>T	ENST00000366787.3	-	6	988	c.739G>A	c.(739-741)Ggt>Agt	p.G247S		NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	247					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		ACATGCGGACCCAGGCGCAGC	0.642000													11	95					0	0	1	0	0
COQ6	51004	broad.mit.edu	37	14	74429684	74429684	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr14:74429684G>A	ENST00000334571.2	+	12	1429	c.1389G>A	c.(1387-1389)atG>atA	p.M463I	ENTPD5_ENST00000557325.1_Intron|COQ6_ENST00000557780.1_3'UTR|ENTPD5_ENST00000334696.6_3'UTR|COQ6_ENST00000238709.4_Missense_Mutation_p.M388I|COQ6_ENST00000394026.4_Missense_Mutation_p.M438I|COQ6_ENST00000554920.1_Missense_Mutation_p.G165S	NM_182476.2	NP_872282.1	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 monooxygenase	463					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(234;0.00337)		AACAGATTATGGCCTTTGCAA	0.338000													18	26					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117553051	117553051	+	Missense_Mutation	SNP	T	T	A			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr9:117553051T>A	ENST00000374045.4	-	4	550	c.437A>T	c.(436-438)gAc>gTc	p.D146V	TNFSF15_ENST00000374044.1_Missense_Mutation_p.D69V	NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	146					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						AATGAAGTAGTCTCCCGACTC	0.512000													18	30					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	31983721	31983721	+	Missense_Mutation	SNP	G	G	T			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr5:31983721G>T	ENST00000438447.1	+	3	1325	c.937G>T	c.(937-939)Ggt>Tgt	p.G313C	PDZD2_ENST00000282493.3_Missense_Mutation_p.G313C			O15018	PDZD2_HUMAN	PDZ domain containing 2	313					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CTTCTCAAAAGGTGGGAAGAC	0.458000													56	126					2.73361e-28	2.89929e-28	1	1	0
USP24	23358	broad.mit.edu	37	1	55612684	55612684	+	Missense_Mutation	SNP	G	G	A			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr1:55612684G>A	ENST00000294383.6	-	19	2167	c.2168C>T	c.(2167-2169)aCt>aTt	p.T723I	USP24_ENST00000407756.1_Missense_Mutation_p.T563I	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	723					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						CAGATACAGAGTAGCTTCTTG	0.393000													6	55					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161926	90161926	+	RNA	SNP	T	T	C	rs8061283	by1000genomes	TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr16:90161926T>C	ENST00000567960.1	+	0	662				TUBB8P7_ENST00000564451.1_RNA														p.I221T(3)									CCCACACCCATCTATGGTGAC	0.527000													4	41					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27458192	27458192	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr2:27458192C>T	ENST00000264705.4	+	24	4028	c.3866C>T	c.(3865-3867)gCc>gTc	p.A1289V	CAD_ENST00000403525.1_Missense_Mutation_p.A1226V	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1289	CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GGGGAGGTGGCCGGCTTTGGG	0.572000													43	68					0	0	1	0	0
ZNF706	51123	broad.mit.edu	37	8	102213962	102213962	+	Missense_Mutation	SNP	C	C	G			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr8:102213962C>G	ENST00000520347.1	-	2	2964	c.8G>C	c.(7-9)cGt>cCt	p.R3P	ZNF706_ENST00000518336.1_Missense_Mutation_p.R3P|ZNF706_ENST00000517844.1_Missense_Mutation_p.R3P|ZNF706_ENST00000519882.1_Missense_Mutation_p.R3P|ZNF706_ENST00000521272.1_Missense_Mutation_p.R3P|ZNF706_ENST00000519744.1_Missense_Mutation_p.R3P|ZNF706_ENST00000520984.1_Missense_Mutation_p.R3P|ZNF706_ENST00000311212.4_Missense_Mutation_p.R3P			Q9Y5V0	ZN706_HUMAN	zinc finger protein 706	3						intracellular	zinc ion binding	p.R3P(2)		large_intestine(1)|ovary(2)	3	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTGCTGTCCACGAGCCATATC	0.398000													6	21					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28194930	28194930	+	Silent	SNP	C	C	T			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr22:28194930C>T	ENST00000302326.4	-	1	2556	c.1602G>A	c.(1600-1602)caG>caA	p.Q534Q		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	534	Poly-Gln.						binding	p.Q550_R551insQ(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						gctgctgctgctgttgctgct	0.647000			T	ETV6	"""AML, meningioma"""								5	10					0	0	1	0	0
CEP164	22897	broad.mit.edu	37	11	117261870	117261870	+	Missense_Mutation	SNP	A	A	G			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr11:117261870A>G	ENST00000278935.3	+	17	2369	c.2222A>G	c.(2221-2223)aAt>aGt	p.N741S	CEP164_ENST00000533706.1_3'UTR	NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	741	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GCTGCCCTGAATGCTGCAAAG	0.557000													18	32					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr3:126707544T>G	ENST00000251772.4	+	1	108	c.39T>G	c.(37-39)ggT>ggG	p.G13G	PLXNA1_ENST00000393409.2_Silent_p.G36G			Q9UIW2	PLXA1_HUMAN	plexin A1	36					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity	p.G13G(4)		breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.682000													7	35					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542734	14542734	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr18:14542734C>T	ENST00000358970.5	-	1	411	c.412G>A	c.(412-414)Gaa>Aaa	p.E138K	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	138										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TCCAGATCTTCTCGACGGACG	0.602000													86	175					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63538597	63538597	+	Silent	SNP	C	C	T			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr7:63538597C>T	ENST00000550760.3	+	4	1349	c.1170C>T	c.(1168-1170)caC>caT	p.H390H		NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						AGAGAATTCACACTGGAGAGA	0.383000													3	20					0	0	1	0	0
ASPDH	554235	broad.mit.edu	37	19	51017835	51017835	+	Translation_Start_Site	SNP	G	G	A	rs889131	by1000genomes	TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr19:51017835G>A	ENST00000376916.3	-	0	112				ASPDH_ENST00000597030.1_5'UTR	NM_001024656.2	NP_001019827.2	A6ND91	ASPD_HUMAN	aspartate dehydrogenase domain containing						NAD biosynthetic process|NADP catabolic process		aspartate dehydrogenase activity|NADP binding			endometrium(1)|large_intestine(1)|lung(1)	3						CCCAGCTCGCGTCAGCCCAGG	0.637000													7	110					0	0	1	0	0
RCOR2	283248	broad.mit.edu	37	11	63679850	63679850	+	Missense_Mutation	SNP	C	C	T			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr11:63679850C>T	ENST00000301459.4	-	11	1571	c.1184G>A	c.(1183-1185)gGa>gAa	p.G395E		NM_173587.3	NP_775858.2	Q8IZ40	RCOR2_HUMAN	REST corepressor 2	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(2)|large_intestine(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	17						GACTGGGGCTCCAGGGGCCCC	0.612000													24	172					0	0	1	0	0
ACAD9	28976	broad.mit.edu	37	3	128618263	128618263	+	Missense_Mutation	SNP	A	A	T			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr3:128618263A>T	ENST00000308982.7	+	7	848	c.767A>T	c.(766-768)aAt>aTt	p.N256I	ACAD9_ENST00000511526.1_3'UTR	NM_014049.4	NP_054768.2	Q9H845	ACAD9_HUMAN	acyl-CoA dehydrogenase family, member 9	256						mitochondrion	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	30						GGAGTCACTAATGGGAAACCC	0.473000													53	61					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16327903	16327903	+	Missense_Mutation	SNP	C	C	A	rs3817753		TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr6:16327903C>A	ENST00000244769.4	-	8	1575	c.639G>T	c.(637-639)caG>caT	p.Q213H	ATXN1_ENST00000436367.1_Missense_Mutation_p.Q213H	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	213	Poly-Gln.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				gctgctgctgctgctgatgct	0.667000													4	18					0.000602214	0.000619927	1	1	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				14	40					0	0	1	0	0
PLK2	10769	broad.mit.edu	37	5	57755770	57755770	+	Missense_Mutation	SNP	G	G	C			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr5:57755770G>C	ENST00000274289.3	-	1	317	c.17C>G	c.(16-18)aCt>aGt	p.T6S		NM_001252226.1|NM_006622.3	NP_001239155.1|NP_006613.2	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	6					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(7)|large_intestine(7)|lung(5)|ovary(3)|prostate(2)|skin(2)	26		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		GTAGGTGATAGTCCGCAAAAG	0.697000													18	31					0	0	1	0	0
CASP7	840	broad.mit.edu	37	10	115485263	115485263	+	Silent	SNP	C	C	G			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr10:115485263C>G	ENST00000369321.2	+	6	938	c.618C>G	c.(616-618)acC>acG	p.T206T	CASP7_ENST00000452490.2_Silent_p.T148T|CASP7_ENST00000345633.4_Silent_p.T173T|CASP7_ENST00000369318.3_Silent_p.T173T|CASP7_ENST00000369331.4_Intron|CASP7_ENST00000369315.1_Silent_p.T173T	NM_033338.5	NP_203124.1	P55210	CASP7_HUMAN	caspase 7, apoptosis-related cysteine peptidase	173					activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis	cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm	cysteine-type endopeptidase activity|protein binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)	8		Colorectal(252;0.0946)|Breast(234;0.188)		Epithelial(162;0.012)|all cancers(201;0.014)		GATGCAAAACCCTTTTAGAGA	0.408000													18	41					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64108629	64108629	+	Silent	SNP	T	T	C			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr11:64108629T>C	ENST00000356786.5	+	4	411	c.367T>C	c.(367-369)Ttg>Ctg	p.L123L	CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	123					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCTCCAGACATTGGGATTTGA	0.627000													26	78					0	0	1	0	0
C11orf45	219833	broad.mit.edu	37	11	128773264	128773264	+	Silent	SNP	C	C	T			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr11:128773264C>T	ENST00000310799.3	-	3	472	c.279G>A	c.(277-279)gtG>gtA	p.V93V	KCNJ5_ENST00000529694.1_Intron|C11orf45_ENST00000524878.1_Silent_p.V93V|KCNJ5_ENST00000338350.4_Intron|C11orf45_ENST00000530168.1_5'UTR	NM_001256088.1|NM_145013.2	NP_001243017.1|NP_659450.1	Q8TAV5	CK045_HUMAN	chromosome 11 open reading frame 45	93						extracellular region				endometrium(1)|kidney(1)|lung(2)|pancreas(1)|prostate(2)	7	all_hematologic(175;0.0641)	Lung NSC(97;0.00521)|Breast(109;0.00715)|all_lung(97;0.0111)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.00531)|LUSC - Lung squamous cell carcinoma(976;0.0193)|Lung(977;0.0195)		GCACTCACCTCACACAGCCAC	0.502000													20	65					0	0	1	0	0
ADC	113451	broad.mit.edu	37	1	33583674	33583675	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr1:33583674_33583675insC	ENST00000294517.6	+	11	1788_1789	c.1201_1202insC	c.(1201-1203)ccafs	p.P401fs	ADC_ENST00000484656.1_3'UTR|ADC_ENST00000398167.1_Frame_Shift_Ins_p.P421fs|ADC_ENST00000373443.3_Frame_Shift_Ins_p.P401fs|ADC_ENST00000373441.1_Frame_Shift_Ins_p.P421fs	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	401					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	CTTTTGGGGGACCCAGGCCTGC	0.624													10	125	---	---	---	---					
GRIP2	80852	broad.mit.edu	37	3	14555758	14555759	+	RNA	INS	-	-	AGTT	rs10656368	by1000genomes	TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr3:14555758_14555759insAGTT	ENST00000273083.3	-	0	1558							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CAGTTTCTCTCAGAGAGTGGCA	0.579													3	3	---	---	---	---					
TLR2	7097	broad.mit.edu	37	4	154625331	154625331	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr4:154625331delT	ENST00000260010.6	+	1	2680	c.1272delT	c.(1270-1272)agfs	p.S424fs		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	424					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				GTAAGAATAGTTTTCATTCTA	0.363													35	35	---	---	---	---					
ATXN1	6310	broad.mit.edu	37	6	16327913	16327915	+	In_Frame_Del	DEL	TGA	TGA	-	rs11969612	by1000genomes	TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr6:16327913_16327915delTGA	ENST00000244769.4	-	8	1563_1565	c.627_629delTCA	c.(625-630)cag>ca	p.HQ211del	ATXN1_ENST00000436367.1_In_Frame_Del_p.HQ211del	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	211	Poly-Gln.			H -> HQ (in Ref. 1; CAA55793).	cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association	p.H209delH(2)|p.H209_H211delHQH(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				ctgctgatgctgatgctgctgct	0.665													9	19	---	---	---	---					
OR4N2	390429	broad.mit.edu	37	14	20296055	20296056	+	Frame_Shift_Ins	INS	-	-	T	rs149523724	by1000genomes	TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr14:20296055_20296056insT	ENST00000315947.1	+	1	448_449	c.448_449insT	c.(448-450)tggfs	p.W150fs	OR4N2_ENST00000568211.1_Frame_Shift_Ins_p.W150fs	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGCTCTGTGGCTTGGGGGTTTT	0.530													23	245	---	---	---	---					
DDX28	55794	broad.mit.edu	37	16	68055898	68055898	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr16:68055898delA	ENST00000332395.5	-	1	1872	c.1208delT	c.(1207-1209)tcfs	p.F403fs		NM_018380.3	NP_060850.2	Q9NUL7	DDX28_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28	403	Helicase C-terminal.					mitochondrial nucleoid|nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	13		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0116)|Epithelial(162;0.0474)|all cancers(182;0.233)		GCTATTACAGAACACCAGAAC	0.517													52	82	---	---	---	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	In_Frame_Del	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	rs483929	by1000genomes	TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	ENST00000398472.1	-	1	742_798	c.255_311delCCCACTCTGCTGTCAGACCACCTGCCACCCCAGCTGTGGTATGTCCAGCTGCTGCCG	c.(253-312)cgt>cg	p.RPLCCQTTCHPSCGMSSCCR85del				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	85	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].		Missing (in allele KAP4.10).			keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													128	57	---	---	---	---					
MYBPC2	4606	broad.mit.edu	37	19	50963366	50963367	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr19:50963366_50963367insG	ENST00000357701.5	+	24	2912_2913	c.2861_2862insG	c.(2860-2862)cgcfs	p.R954fs		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	954	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GTGGAGTGGCAGGCCCCCAAAG	0.550													7	17	---	---	---	---					
TRIOBP	11078	broad.mit.edu	37	22	38119882	38119884	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-FY-A40L-01A-11D-A23M-08	TCGA-FY-A40L-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	382b11e1-7464-4ff6-948b-c377540e1023	4d8e07aa-04c1-4f2c-a849-1ffe44f3fdb0	g.chr22:38119882_38119884delCCT	ENST00000406386.3	+	7	1574_1576	c.1319_1321delCCT	c.(1318-1323)gcc>g	p.AS440del	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	440					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AATCCCAGAGCCTCCTCTCCCAG	0.601													9	167	---	---	---	---					
