Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBC	7316	broad.mit.edu	37	12	125397415	125397415	+	Silent	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr12:125397415G>A	ENST00000536769.1	-	1	2479	c.903C>T	c.(901-903)ctC>ctT	p.L301L	UBC_ENST00000538617.1_Intron|UBC_ENST00000546120.1_Silent_p.L225L|UBC_ENST00000339647.5_Silent_p.L301L			P0CG48	UBC_HUMAN	ubiquitin C	301	Ubiquitin-like 4.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TCCCACCTCTGAGACGGAGCA	0.532000													5	144					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P|FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													8	190					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62199815	62199815	+	Missense_Mutation	SNP	G	G	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr20:62199815G>C	ENST00000467148.1	-	5	1695	c.1626C>G	c.(1624-1626)atC>atG	p.I542M	RP4-697K14.12_ENST00000454223.1_RNA	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		AGGGGCCATAGATGAGTAGCG	0.667000													6	5					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70450954	70450954	+	Missense_Mutation	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr18:70450954C>T	ENST00000327305.6	-	7	1484	c.827G>A	c.(826-828)cGa>cAa	p.R276Q	NETO1_ENST00000299430.2_Missense_Mutation_p.R275Q|NETO1_ENST00000583169.1_Missense_Mutation_p.R276Q	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	276	CUB 2.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TCGGCTGTTTCGACTGCCCTC	0.463000													8	164					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113856738	113856738	+	Splice_Site	SNP	C	C	G			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr11:113856738C>G	ENST00000504030.2	+	6	991	c.544_splice	c.e6-1	p.I182_splice	HTR3A_ENST00000506841.2_Splice_Site_p.I182_splice|HTR3A_ENST00000375498.2_Splice_Site_p.I188_splice|HTR3A_ENST00000299961.5_Splice_Site_p.I167_splice|HTR3A_ENST00000355556.2_Splice_Site_p.I188_splice|HTR3A_ENST00000535865.1_Intron			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	182					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	CTCTCTCAGTCCAGGACATCA	0.532000													5	344					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13601009	13601009	+	Silent	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr4:13601009C>T	ENST00000040738.5	-	10	7650	c.7515G>A	c.(7513-7515)ctG>ctA	p.L2505L		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2505							DNA binding										CTGGTCCTCTCAGGTGGGCAG	0.532000											OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	49					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													3	12					0	0	1	0	0
OTUD4	54726	broad.mit.edu	37	4	146059006	146059006	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr4:146059006G>A	ENST00000454497.2	-	21	2863	c.2726C>T	c.(2725-2727)aCt>aTt	p.T909I	OTUD4_ENST00000455611.2_Intron|OTUD4_ENST00000447906.2_Missense_Mutation_p.T974I	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	973							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					AACAGGCACAGTTTCTCTCTC	0.463000													5	198					0	0	1	0	0
WDR34	89891	broad.mit.edu	37	9	131397371	131397371	+	Splice_Site	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr9:131397371C>T	ENST00000372715.2	-	6	1041	c.981_splice	c.e6+1	p.K327_splice	WDR34_ENST00000483181.1_5'UTR	NM_052844.3	NP_443076.2	Q96EX3	WDR34_HUMAN	WD repeat domain 34	327						cytoplasm				central_nervous_system(2)|lung(5)|skin(1)|urinary_tract(1)	9						GCCCACGTACCTTCTTGAGCT	0.647000											OREG0019522	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	55					0	0	1	0	0
BBS2	583	broad.mit.edu	37	16	56535329	56535329	+	Silent	SNP	G	G	C	rs71387119		TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr16:56535329G>C	ENST00000245157.5	-	10	1581	c.1161C>G	c.(1159-1161)ctC>ctG	p.L387L	BBS2_ENST00000568104.1_Silent_p.L387L	NM_031885.3	NP_114091.3	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2	387					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)	26						GGCTGACTGAGAGCGTGGTGT	0.522000									Bardet-Biedl syndrome				5	194					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													3	56					0	0	1	0	0
TET2	54790	broad.mit.edu	37	4	106156119	106156119	+	Missense_Mutation	SNP	C	C	G			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr4:106156119C>G	ENST00000513237.1	+	3	1880	c.1083C>G	c.(1081-1083)atC>atG	p.I361M	TET2_ENST00000413648.2_Missense_Mutation_p.I340M|TET2_ENST00000305737.2_Missense_Mutation_p.I340M|TET2_ENST00000545826.1_Missense_Mutation_p.I340M|TET2_ENST00000540549.1_Missense_Mutation_p.I340M|TET2_ENST00000380013.4_Missense_Mutation_p.I340M|TET2_ENST00000394764.1_Missense_Mutation_p.I340M			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	340					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.Q341fs*6(1)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		AAAATAACATCCAGGGAACCA	0.418000			"""Mis N, F"""		MDS								4	66					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233272321	233272321	+	Silent	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr2:233272321G>A	ENST00000295453.3	+	4	370	c.318G>A	c.(316-318)aaG>aaA	p.K106K		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	106					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GTGTAGACAAGCATGTGCCAG	0.567000													4	51					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42490290	42490290	+	Missense_Mutation	SNP	G	G	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr19:42490290G>C	ENST00000545399.1	-	5	641	c.488C>G	c.(487-489)tCc>tGc	p.S163C	ATP1A3_ENST00000602133.1_Missense_Mutation_p.S120C|ATP1A3_ENST00000543770.1_Missense_Mutation_p.S161C|ATP1A3_ENST00000302102.5_Missense_Mutation_p.S150C	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	150					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						GTTCTTGAAGGACTCCATGAT	0.632000													4	94					0	0	1	0	0
C1orf213	0	broad.mit.edu	37	1	23695869	23695869	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr1:23695869G>A	ENST00000335648.3	+	1	141	c.79G>A	c.(79-81)Gca>Aca	p.A27T	ZNF436_ENST00000314011.4_5'UTR|C1orf213_ENST00000458053.1_Intron|C1orf213_ENST00000518821.1_Intron|C1orf213_ENST00000454117.1_Missense_Mutation_p.A27T|C1orf213_ENST00000437367.2_Missense_Mutation_p.A27T																kidney(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.97e-26)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;5.23e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		CTCCTGTCCCGCAAAAGATCC	0.572000													4	58					0	0	1	0	0
FAM86DP	0	broad.mit.edu	37	3	75475639	75475639	+	RNA	SNP	T	T	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr3:75475639T>C	ENST00000459803.1	-	0	890					NR_024241.1													p.H284R(1)									CTCTGGGTTGTGGACGGTAAA	0.662000													4	112					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117803286	117803286	+	Missense_Mutation	SNP	G	G	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr9:117803286G>C	ENST00000350763.4	-	19	5737	c.5326C>G	c.(5326-5328)Ctt>Gtt	p.L1776V	TNC_ENST00000535648.1_Missense_Mutation_p.L1321V|TNC_ENST00000423613.2_Missense_Mutation_p.L1503V|TNC_ENST00000340094.3_Missense_Mutation_p.L1412V|TNC_ENST00000537320.1_Missense_Mutation_p.L1139V|TNC_ENST00000341037.4_Missense_Mutation_p.L1594V|TNC_ENST00000346706.3_Missense_Mutation_p.L1230V|TNC_ENST00000345230.3_Missense_Mutation_p.L1139V|TNC_ENST00000542877.1_Missense_Mutation_p.L1413V	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1776	Fibronectin type-III 13.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding	p.L1776I(1)		NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						ATGCTGACAAGGTACTCCACG	0.512000													7	57					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													3	12					0.00909568	0.00922562	1	1	0
POM121L9P	0	broad.mit.edu	37	22	24659591	24659591	+	RNA	SNP	A	A	G			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr22:24659591A>G	ENST00000414583.2	+	0	3116					NR_003714.1																						ACTCACTGACATCGAAGGCTG	0.632000													6	31					0	0	1	0	0
ZBTB43	23099	broad.mit.edu	37	9	129595683	129595683	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr9:129595683G>A	ENST00000373464.4	+	3	1159	c.895G>A	c.(895-897)Gaa>Aaa	p.E299K	ZBTB43_ENST00000449886.1_Missense_Mutation_p.E299K|ZBTB43_ENST00000373457.1_Missense_Mutation_p.E299K	NM_014007.3	NP_054726.1	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						GAAGAAAGTGGAAGCTGAGTT	0.522000													15	23					0	0	1	0	0
CC2D2A	57545	broad.mit.edu	37	4	15559105	15559105	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr4:15559105G>A	ENST00000424120.1	+	21	3058	c.2804G>A	c.(2803-2805)cGa>cAa	p.R935Q	CC2D2A_ENST00000413206.1_Missense_Mutation_p.R935Q|CC2D2A_ENST00000389652.5_Missense_Mutation_p.R886Q|CC2D2A_ENST00000503292.1_Missense_Mutation_p.R935Q			Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A	935					cell projection organization	cilium|microtubule basal body				NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|urinary_tract(2)	32						GTCTATGACCGAGAAATTATG	0.358000													7	9					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				32	33					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													3	62					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	41					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276075	186276075	+	Silent	SNP	T	T	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr1:186276075T>C	ENST00000445192.2	+	7	1269	c.1224T>C	c.(1222-1224)acT>acC	p.T408T	PRG4_ENST00000367486.3_Silent_p.T365T|PRG4_ENST00000367483.4_Silent_p.T367T|PRG4_ENST00000367485.4_Silent_p.T315T|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	408	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity	p.T408T(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CACCCACCACTCCCAAGGAGC	0.662000													12	132					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161618	90161618	+	RNA	SNP	C	C	T	rs13338202	by1000genomes	TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr16:90161618C>T	ENST00000564451.1	+	0	971				TUBB8P7_ENST00000567960.1_RNA														p.D118D(2)									CAGTGATGGACGTTGTCAGAA	0.607000													4	20					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713944	142713944	+	RNA	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr1:142713944C>T	ENST00000369381.2	-	0	661																											TGATTACCTCCGAAGTTAAAG	0.308000													3	18					0	0	1	0	0
POM121L9P	0	broad.mit.edu	37	22	24659593	24659593	+	RNA	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr22:24659593C>T	ENST00000414583.2	+	0	3118					NR_003714.1																						TCACTGACATCGAAGGCTGCC	0.632000													6	32					0	0	1	0	0
SLC30A5	64924	broad.mit.edu	37	5	68417622	68417622	+	Silent	SNP	A	A	G	rs144055477		TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr5:68417622A>G	ENST00000396591.3	+	13	2281	c.1671A>G	c.(1669-1671)tcA>tcG	p.S557S	CTC-498J12.3_ENST00000504129.1_RNA	NM_022902.4	NP_075053.2	Q8TAD4	ZNT5_HUMAN	solute carrier family 30 (zinc transporter), member 5	557	His-rich loop.				cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		GCTGTCACTCATCTGATCACA	0.517000													11	18					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237236	56237236	+	Silent	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr11:56237236G>A	ENST00000312240.2	-	1	778	c.738C>T	c.(736-738)gtC>gtT	p.V246V		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	246					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					AGAATATAATGACAGCTGTCA	0.478000													4	64					0	0	1	0	0
MRPL41	64975	broad.mit.edu	37	9	140446550	140446550	+	Missense_Mutation	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr9:140446550C>T	ENST00000371443.5	+	2	805	c.17C>T	c.(16-18)gCa>gTa	p.A6V		NM_032477.2	NP_115866.1	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	6					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			breast(1)|lung(1)	2	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		GTCCTGGCCGCAGCGGCGCGC	0.796000													9	29					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49005719	49005719	+	Silent	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr19:49005719C>T	ENST00000600059.1	-	7	992	c.765G>A	c.(763-765)gcG>gcA	p.A255A	LMTK3_ENST00000270238.3_Silent_p.A284A					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		AATGCAGGTGCGCCAGCCCGC	0.716000													4	62					0	0	1	0	0
LILRA3	0	broad.mit.edu	37	19	54802035	54802035	+	Missense_Mutation	SNP	T	T	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr19:54802035T>C	ENST00000391745.1	-	10	1520	c.1204A>G	c.(1204-1206)Agt>Ggt	p.S402G	LILRA3_ENST00000391744.3_Missense_Mutation_p.S321G|LILRA3_ENST00000251390.3_Missense_Mutation_p.S385G					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTCACAGGACTCATGGGGAAT	0.582000													4	110					0	0	1	0	0
TRIP13	9319	broad.mit.edu	37	5	911973	911973	+	Silent	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr5:911973G>A	ENST00000166345.3	+	10	1238	c.882G>A	c.(880-882)gtG>gtA	p.V294V		NM_004237.3	NP_004228.1	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	294					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	18			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			CCAATGTTGTGATTCTGACCA	0.542000													5	77					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3747863	3747863	+	Missense_Mutation	SNP	C	C	G			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr19:3747863C>G	ENST00000541714.2	+	19	2856	c.2394C>G	c.(2392-2394)agC>agG	p.S798R	TJP3_ENST00000587686.1_Missense_Mutation_p.S817R|TJP3_ENST00000539908.2_Missense_Mutation_p.S762R|TJP3_ENST00000589378.1_Missense_Mutation_p.S807R|TJP3_ENST00000382008.3_Missense_Mutation_p.S812R|TJP3_ENST00000262968.9_Missense_Mutation_p.S831R	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	812						tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGACCTCAGCTGCGACAGCC	0.682000													14	32					0	0	1	0	0
ZDHHC23	254887	broad.mit.edu	37	3	113673157	113673157	+	Missense_Mutation	SNP	G	G	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr3:113673157G>C	ENST00000330212.3	+	3	1071	c.772G>C	c.(772-774)Gag>Cag	p.E258Q	ZDHHC23_ENST00000498275.1_Missense_Mutation_p.E252Q	NM_173570.3	NP_775841.2	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC-type containing 23	258						integral to membrane	acyltransferase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|urinary_tract(2)	16						CAAAGCGAAGGAGGACTGGTG	0.582000													10	38					0	0	1	0	0
PSMC5	5705	broad.mit.edu	37	17	61907309	61907309	+	Splice_Site	SNP	G	G	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr17:61907309G>C	ENST00000310144.6	+	4	572	c.264_splice	c.e4+1	p.K88_splice	PSMC5_ENST00000581882.1_Splice_Site_p.K80_splice|PSMC5_ENST00000580864.1_Splice_Site_p.K80_splice|FTSJ3_ENST00000580295.1_5'UTR|PSMC5_ENST00000375812.4_Splice_Site_p.K80_splice	NM_002805.5	NP_002796.4	P62195	PRS8_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 5	88					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of programmed cell death|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|thyrotropin-releasing hormone receptor binding|transcription cofactor activity|transcription factor binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	20						TGTTGGTCAAGGTAAAAGCAG	0.557000													13	51					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661362	22661362	+	RNA	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr22:22661362C>T	ENST00000426066.1	+	0	360					NR_027293.1																						TGGGCAACAGCGAGGGAAATG	0.502000													4	66					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30704985	30704985	+	Missense_Mutation	SNP	C	C	G			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr8:30704985C>G	ENST00000256246.2	-	1	1623	c.1549G>C	c.(1549-1551)Gat>Cat	p.D517H		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	517										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TCCTTTTCATCTATATTGCTG	0.313000													13	30					0	0	1	0	0
TCHP	84260	broad.mit.edu	37	12	110350871	110350871	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr12:110350871G>A	ENST00000312777.5	+	10	1342	c.1128G>A	c.(1126-1128)atG>atA	p.M376I	TCHP_ENST00000405876.4_Missense_Mutation_p.M376I	NM_032300.4	NP_115676.1	Q9BT92	TCHP_HUMAN	trichoplein, keratin filament binding	376	Glu-rich.|Interaction with keratin proteins.|Trichohyalin/plectin homology domain.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|skin(2)	22						ACAGACTGATGAGCGAGGTAA	0.602000													4	73					0	0	1	0	0
MKLN1	4289	broad.mit.edu	37	7	131172392	131172392	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr7:131172392G>A	ENST00000352689.6	+	18	2153	c.2113G>A	c.(2113-2115)Gct>Act	p.A705T	MKLN1_ENST00000421797.2_Missense_Mutation_p.A613T|MKLN1_ENST00000498778.1_3'UTR	NM_013255.4	NP_037387.2	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing kelch motifs	705					signal transduction	cytoplasm	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	28	Melanoma(18;0.162)					TCACACCTATGCTCAAAGAAC	0.408000													10	58					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26527933	26527933	+	Missense_Mutation	SNP	G	G	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr1:26527933G>C	ENST00000456354.2	+	9	1355	c.1288G>C	c.(1288-1290)Gag>Cag	p.E430Q		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	430					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		CGGGTCGTTGGAGACTACGTC	0.577000													8	97					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74667954	74667954	+	Missense_Mutation	SNP	C	C	G			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr18:74667954C>G	ENST00000253159.8	+	28	5120	c.4922C>G	c.(4921-4923)tCt>tGt	p.S1641C	ZNF236_ENST00000320610.9_Missense_Mutation_p.S1643C	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1641					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GCTGGCGTCTCTGGGAACCTG	0.592000													7	14					0	0	1	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177590	89177590	+	Missense_Mutation	SNP	G	G	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chrX:89177590G>C	ENST00000561129.2	+	1	636	c.506G>C	c.(505-507)aGa>aCa	p.R169T	TGIF2LX_ENST00000283891.5_Missense_Mutation_p.R169T			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	169						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						CAGATGTCAAGAGAGAAGCAA	0.587000													3	50					0	0	1	0	0
PDE12	201626	broad.mit.edu	37	3	57542553	57542553	+	Missense_Mutation	SNP	G	G	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr3:57542553G>C	ENST00000311180.8	+	1	550	c.447G>C	c.(445-447)caG>caC	p.Q149H	PDE12_ENST00000487257.1_Missense_Mutation_p.Q149H	NM_177966.5	NP_808881.3	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	149							hydrolase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(4)|lung(3)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		CGGTGCTGCAGATCGGCGATG	0.622000													4	54					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99697773	99697773	+	Missense_Mutation	SNP	C	C	G			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr2:99697773C>G	ENST00000393483.3	-	11	1543	c.699G>C	c.(697-699)gaG>gaC	p.E233D	TSGA10_ENST00000539964.1_Missense_Mutation_p.E233D|TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000542655.1_Missense_Mutation_p.E233D|TSGA10_ENST00000410001.1_Missense_Mutation_p.E233D|TSGA10_ENST00000355053.4_Missense_Mutation_p.E233D	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	233					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						ACATAATTTTCTCCTGAGTAA	0.299000													25	38					0	0	1	0	0
MRPL41	64975	broad.mit.edu	37	9	140446549	140446549	+	Missense_Mutation	SNP	G	G	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr9:140446549G>T	ENST00000371443.5	+	2	804	c.16G>T	c.(16-18)Gca>Tca	p.A6S		NM_032477.2	NP_115866.1	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	6					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			breast(1)|lung(1)	2	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		CGTCCTGGCCGCAGCGGCGCG	0.796000													9	27					0.000274275	0.000282225	1	1	0
DDX54	79039	broad.mit.edu	37	12	113603644	113603644	+	Silent	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr12:113603644C>T	ENST00000314045.7	-	13	1635	c.1608G>A	c.(1606-1608)gaG>gaA	p.E536E	DDX54_ENST00000306014.5_Silent_p.E536E	NM_001111322.1	NP_001104792.1	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	536					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CAAGGTCCATCTCCTTGGCCC	0.662000													15	32					0	0	1	0	0
ZNF512B	57473	broad.mit.edu	37	20	62593668	62593668	+	Missense_Mutation	SNP	C	C	G			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr20:62593668C>G	ENST00000450537.1	-	14	2283	c.2223G>C	c.(2221-2223)aaG>aaC	p.K741N	ZNF512B_ENST00000217130.3_Missense_Mutation_p.K741N|ZNF512B_ENST00000369888.1_Missense_Mutation_p.K741N			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	741					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TCACTTCATTCTTCCATGCCT	0.622000													5	129					0	0	1	0	0
LRCH3	84859	broad.mit.edu	37	3	197598202	197598202	+	Missense_Mutation	SNP	G	G	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr3:197598202G>C	ENST00000438796.2	+	19	2043	c.1999G>C	c.(1999-2001)Gag>Cag	p.E667Q	LRCH3_ENST00000425562.2_Missense_Mutation_p.E667Q|LRCH3_ENST00000334859.4_Missense_Mutation_p.E667Q|LRCH3_ENST00000536618.1_Missense_Mutation_p.E262Q|LRCH3_ENST00000414675.2_Missense_Mutation_p.E615Q|LRCH3_ENST00000441090.2_Missense_Mutation_p.E513Q			Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 3	667	CH.					extracellular region				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		TCAGCATATTGAGTACCGGTT	0.373000													4	132					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977327	29977327	+	RNA	SNP	T	T	C	rs143365191	by1000genomes	TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr6:29977327T>C	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							GACAGCTGCCTTGTGTGGGAC	0.438000													3	56					0	0	1	0	0
ZNF778	197320	broad.mit.edu	37	16	89294617	89294617	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr16:89294617G>A	ENST00000433976.2	+	6	2169	c.1837G>A	c.(1837-1839)Ggt>Agt	p.G613S	ZNF778_ENST00000306502.6_Missense_Mutation_p.G571S|RP11-46C24.6_ENST00000563182.1_RNA	NM_001201407.1|NM_182531.3	NP_001188336.1|NP_872337.2	Q96MU6	ZN778_HUMAN	zinc finger protein 778	613					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|skin(2)	24				BRCA - Breast invasive adenocarcinoma(80;0.0269)		AACCCACACCGGTGAGAAACC	0.463000													4	91					0	0	1	0	0
C17orf97	400566	broad.mit.edu	37	17	263322	263322	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr17:263322G>A	ENST00000360127.6	+	2	704	c.688G>A	c.(688-690)Gag>Aag	p.E230K	AC108004.3_ENST00000466740.2_RNA|C17orf97_ENST00000571106.1_Intron	NM_001013672.4	NP_001013694.4	Q6ZQX7	CQ097_HUMAN	chromosome 17 open reading frame 97	230	20 X 10 AA approximative tandem repeat of A-L-K-G-F-H-P-D-P-E.									breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)	14						CCCCGACCCCGAGGCCCTCAA	0.716000													4	29					0	0	1	0	0
FAM86DP	0	broad.mit.edu	37	3	75475607	75475607	+	RNA	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr3:75475607C>T	ENST00000459803.1	-	0	922					NR_024241.1																						TCACCTAGCTCGGTGGTGAAC	0.652000													4	129					0	0	1	0	0
C12orf65	91574	broad.mit.edu	37	12	123738272	123738272	+	Silent	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr12:123738272C>T	ENST00000253233.1	+	2	695	c.51C>T	c.(49-51)tgC>tgT	p.C17C	RP11-282O18.3_ENST00000541002.3_RNA|C12orf65_ENST00000366329.2_Silent_p.C17C|C12orf65_ENST00000429587.2_Silent_p.C17C	NM_152269.4	NP_689482.1	Q9H3J6	CL065_HUMAN	chromosome 12 open reading frame 65	17						mitochondrion	translation release factor activity			endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	4	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000595)|Epithelial(86;0.00199)		CCCGAATATGCCCGGCGCCAT	0.542000													4	103					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186277190	186277190	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr1:186277190G>A	ENST00000445192.2	+	7	2384	c.2339G>A	c.(2338-2340)gGg>gAg	p.G780E	PRG4_ENST00000367486.3_Missense_Mutation_p.G737E|PRG4_ENST00000367483.4_Missense_Mutation_p.G739E|PRG4_ENST00000367485.4_Missense_Mutation_p.G687E|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	780	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						ACCCCTAAGGGGACTGCTCCA	0.607000													5	248					0	0	1	0	0
HLA-C	3107	broad.mit.edu	37	6	31239819	31239819	+	Silent	SNP	G	G	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr6:31239819G>T	ENST00000383329.3	-	1	44	c.30C>A	c.(28-30)ctC>ctA	p.L10L	HLA-C_ENST00000376228.5_Silent_p.L10L			Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	10					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	17						AGAGCAGCAGGAGGAGGGCTC	0.697000													8	14					1.33987e-11	1.39898e-11	1	1	0
FAM86DP	0	broad.mit.edu	37	3	75475600	75475600	+	RNA	SNP	C	C	G			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr3:75475600C>G	ENST00000459803.1	-	0	929					NR_024241.1																						TGGGGGCTCACCTAGCTCGGT	0.642000													4	128					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71346978	71346978	+	Missense_Mutation	SNP	T	T	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr4:71346978T>C	ENST00000413702.1	+	4	805	c.517T>C	c.(517-519)Tct>Cct	p.S173P	MUC7_ENST00000514512.1_3'UTR|MUC7_ENST00000304887.5_Missense_Mutation_p.S173P|MUC7_ENST00000456088.1_Missense_Mutation_p.S173P	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	173	Thr-rich.					extracellular region	protein binding	p.S173P(3)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.522000													5	214					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600418	29600418	+	Missense_Mutation	SNP	C	C	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr13:29600418C>T	ENST00000431530.3	+	1	1671	c.1613C>T	c.(1612-1614)tCa>tTa	p.S538L		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	528						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						AGAGCAGATTCAGTTCTCAAT	0.473000													5	71					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112824048	112824049	+	In_Frame_Ins	INS	-	-	GCC	rs35336557		TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr5:112824048_112824049insGCC	ENST00000408903.3	-	1	478_479	c.63_64insGGC	c.(61-66)gggcgg>ggGGCgcgg	p.21_22GR>GAR		NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	549					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		ctgctgccgctgccgccgccgc	0.738													7	6	---	---	---	---					
RP11-586K2.1	0	broad.mit.edu	37	8	89498121	89498122	+	RNA	INS	-	-	A			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr8:89498121_89498122insA	ENST00000521433.1	+	0	179				RP11-586K2.1_ENST00000523254.1_RNA																							gaacagctatgaaaaaaaaaac	0.386													3	4	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651199	1651200	+	In_Frame_Ins	INS	-	-	GGCTGTGGCTCC	rs71025763		TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr11:1651199_1651200insGGCTGTGGCTCC	ENST00000399676.2	+	1	167_168	c.129_130insGGCTGTGGCTCC	c.(127-132)gggctg>ggGGCTGTGGCTCCgctg	p.43_44GL>GAVAPL		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	43				G -> GGCGS (in Ref. 1; BAD20201 and 2; CAF31639).		keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ccggctgtggaggctgtggggg	0.713													48	40	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132547093	132547094	+	In_Frame_Ins	INS	-	-	CAG	rs113304321	by1000genomes	TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr12:132547093_132547094insCAG	ENST00000333577.4	+	48	8398_8399	c.8289_8290insCAG	c.(8287-8292)caagca>caCAGagca	p.2763_2763Q>HR	EP400_ENST00000330386.6_In_Frame_Ins_p.2646_2646Q>HR|EP400_ENST00000389562.2_In_Frame_Ins_p.2726_2726Q>HR|EP400_ENST00000389561.2_In_Frame_Ins_p.2727_2727Q>HR|EP400_ENST00000332482.4_In_Frame_Ins_p.2690_2690Q>HR			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagca	0.564													23	53	---	---	---	---					
TRAV24	0	broad.mit.edu	37	14	22573825	22573826	+	RNA	INS	-	-	A	rs33991650	by1000genomes	TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr14:22573825_22573826insA	ENST00000390453.1	+	0	55																											GACTCTTTTTTAAAAAAACAGG	0.450													7	13	---	---	---	---					
BEGAIN	57596	broad.mit.edu	37	14	101004529	101004530	+	Frame_Shift_Ins	INS	-	-	C			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr14:101004529_101004530insC	ENST00000556751.1	-	5	4770_4771	c.1366_1367insG	c.(1366-1368)cggfs	p.R456fs	BEGAIN_ENST00000355173.2_Frame_Shift_Ins_p.R520fs|BEGAIN_ENST00000443071.2_Frame_Shift_Ins_p.R520fs			Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	520						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				CCTGTCCCCGTCCCCCCCCTCG	0.733													3	6	---	---	---	---					
SLC24A1	9187	broad.mit.edu	37	15	65918177	65918179	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr15:65918177_65918179delCTG	ENST00000261892.6	+	2	2046_2048	c.1759_1761delCTG	c.(1759-1761)del	p.L591del	SLC24A1_ENST00000339868.6_In_Frame_Del_p.L591del|SLC24A1_ENST00000546330.1_In_Frame_Del_p.L591del|SLC24A1_ENST00000544319.2_In_Frame_Del_p.L591del|SLC24A1_ENST00000537259.1_In_Frame_Del_p.L591del|SLC24A1_ENST00000399033.4_In_Frame_Del_p.L591del	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	591					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						GTGGGAGAGCCTGCTGCTGCTGC	0.547													9	109	---	---	---	---					
USP32P2	0	broad.mit.edu	37	17	18431578	18431579	+	RNA	INS	-	-	T			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr17:18431578_18431579insT	ENST00000425211.1	-	0	1497																											TGACCTCGGGCTTTTTTTTTCT	0.441													2	4	---	---	---	---					
TTC25	83538	broad.mit.edu	37	17	40107001	40107001	+	RNA	DEL	T	T	-			TCGA-IM-A41Y-01A-11D-A23U-08	TCGA-IM-A41Y-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d038b3de-369a-4e8b-8533-bec87a61dedb	4f7e0b18-469e-4124-ae29-dc62d93bed92	g.chr17:40107001delT	ENST00000591658.1	+	0	1213							Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25							cytoplasm	protein binding			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				CACCAACGCCTTTGAATGAGG	0.522													2	4	---	---	---	---					
