Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NRAS	4893	broad.mit.edu	37	1	115256530	115256530	+	Missense_Mutation	SNP	G	G	T	rs121913254		TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr1:115256530G>T	ENST00000369535.4	-	3	434	c.181C>A	c.(181-183)Caa>Aaa	p.Q61K		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61K(595)|p.Q61E(9)|p.Q61L(3)|p.Q61R(2)|p.G60>?(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTCTTGTCCAGCTGTA	0.458000	Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(HCC15_LUNG)|Q61K(HS936T_SKIN)|Q61K(HS944T_SKIN)|Q61K(HT1080_SOFT_TISSUE)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH1299_LUNG)|Q61K(NCIH2087_LUNG)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(TYKNU_OVARY)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			76	154					1.25089e-41	1.30092e-41	1	1	0
EPHB6	0	broad.mit.edu	37	7	142564018	142564018	+	Missense_Mutation	SNP	T	T	G			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr7:142564018T>G	ENST00000392957.2	+	9	2193	c.1406T>G	c.(1405-1407)cTc>cGc	p.L469R	EPHB6_ENST00000442129.1_Missense_Mutation_p.L469R|EPHB6_ENST00000411471.2_Missense_Mutation_p.L192R	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	469	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GTGTCTGAGCTCAGCCCTGAC	0.592000													8	33					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17322762	17322762	+	Silent	SNP	C	C	T			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr19:17322762C>T	ENST00000594824.1	+	40	6264	c.6117C>T	c.(6115-6117)acC>acT	p.T2039T	MYO9B_ENST00000595618.1_3'UTR|MYO9B_ENST00000397274.2_3'UTR			Q13459	MYO9B_HUMAN	myosin IXB	2039	Tail.			TVAAPP -> PWPPLH (in Ref. 3; AAC26597).	actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						CCCTCCCCACCGTGGCCGCCC	0.692000													3	15					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25572628	25572628	+	Silent	SNP	G	G	A			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr18:25572628G>A	ENST00000269141.3	-	9	1758	c.1335C>T	c.(1333-1335)acC>acT	p.T445T	CDH2_ENST00000399380.3_Silent_p.T414T	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	445	Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CTTTGACCACGGTGACTAACC	0.517000													17	54					0	0	1	0	0
NDUFA10	4705	broad.mit.edu	37	2	240923063	240923063	+	Silent	SNP	C	C	T			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr2:240923063C>T	ENST00000307300.4	-	11	1183	c.1161G>A	c.(1159-1161)gtG>gtA	p.V387V	NDUFA10_ENST00000404554.1_Intron|NDUFA10_ENST00000252711.2_Intron			O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	0					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)	16		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	tgccaggctgcactgacagca	0.577000													6	11					0	0	1	0	0
ANKFY1	51479	broad.mit.edu	37	17	4076666	4076666	+	Silent	SNP	G	G	A			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr17:4076666G>A	ENST00000341657.4	-	21	3032	c.2997C>T	c.(2995-2997)gcC>gcT	p.A999A	ANKFY1_ENST00000574367.1_Silent_p.A1000A|CYB5D2_ENST00000573984.1_Intron|ANKFY1_ENST00000570535.1_Silent_p.A1041A	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	999						endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						TAAAGGCTTCGGCGTCCACTG	0.602000													29	66					0	0	1	0	0
FOXRED1	55572	broad.mit.edu	37	11	126139160	126139160	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr11:126139160G>A	ENST00000263578.5	+	1	133	c.59G>A	c.(58-60)gGc>gAc	p.G20D	FOXRED1_ENST00000442061.2_5'UTR|FOXRED1_ENST00000532125.1_5'UTR|FOXRED1_ENST00000534011.1_3'UTR	NM_017547.3	NP_060017.1	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing 1	20						integral to membrane|mitochondrion	oxidoreductase activity|protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	15	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		CGGAGGCCAGGCACGCGCAGA	0.617000													28	54					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40330198	40330198	+	Missense_Mutation	SNP	T	T	C			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr17:40330198T>C	ENST00000264661.3	-	4	837	c.505A>G	c.(505-507)Aga>Gga	p.R169G	KCNH4_ENST00000607371.1_Missense_Mutation_p.R169G	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	169					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTCCGTCTTCTGGCAGACCGA	0.592000													40	96					0	0	1	0	0
SRSF11	9295	broad.mit.edu	37	1	70694137	70694137	+	Missense_Mutation	SNP	G	G	A			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr1:70694137G>A	ENST00000370950.3	+	3	318	c.236G>A	c.(235-237)tGc>tAc	p.C79Y	SRSF11_ENST00000454435.2_Missense_Mutation_p.C79Y|SRSF11_ENST00000405432.1_Missense_Mutation_p.C79Y|SRSF11_ENST00000370951.1_Missense_Mutation_p.C79Y|SRSF11_ENST00000436161.2_Missense_Mutation_p.C79Y			Q05519	SRS11_HUMAN	serine/arginine-rich splicing factor 11	79	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			large_intestine(3)|ovary(2)|skin(1)	6						TCTCGTGTCTGCTTTGTTAAG	0.378000													9	107					0	0	1	0	0
RP5-998N21.4	0	broad.mit.edu	37	1	149377834	149377839	+	RNA	DEL	TCTTTG	TCTTTG	-			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr1:149377834_149377839delTCTTTG	ENST00000415338.1	-	0	1061																											GTATCTCTTCTCTTTGTCTTTTTCTG	0.461													3	6	---	---	---	---					
HRCT1	646962	broad.mit.edu	37	9	35906584	35906586	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr9:35906584_35906586delCCA	ENST00000354323.2	+	1	396_398	c.300_302delCCA	c.(298-303)ctc>ct	p.LH100del		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	100	His-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						ctcaccacctccaccaccaccac	0.660													8	20	---	---	---	---					
AGAP4	119016	broad.mit.edu	37	10	46342668	46342688	+	In_Frame_Del	DEL	GCTCCTGCCATCCTGTCCCCA	GCTCCTGCCATCCTGTCCCCA	-			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr10:46342668_46342688delGCTCCTGCCATCCTGTCCCCA	ENST00000448048.2	-	1	233_253	c.108_128delTGGGGACAGGATGGCAGGAGC	c.(106-129)gcg>gc	p.AGDRMAGA36del	AGAP4_ENST00000430779.2_5'UTR	NM_133446.2	NP_597703.2	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4	36					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding	p.G37_A43delGDRMAGA(1)		central_nervous_system(1)|lung(1)|ovary(1)	3						AGCCATGGGCGCTCCTGCCATCCTGTCCCCAGCTCCTGCCT	0.588													4	6	---	---	---	---					
RRN3P1	0	broad.mit.edu	37	16	21817398	21817399	+	RNA	INS	-	-	A	rs144931984	by1000genomes	TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr16:21817398_21817399insA	ENST00000546471.1	-	0	1607																											TAAATGaaaataaaaaaataaa	0.302													7	7	---	---	---	---					
AP001347.6	0	broad.mit.edu	37	21	15436915	15436915	+	RNA	DEL	G	G	-			TCGA-IM-A41Z-01A-11D-A23M-08	TCGA-IM-A41Z-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97bc9b09-16d9-4f75-afd4-202d31227e7e	8569bd7b-8d5c-4618-9226-586227528f73	g.chr21:15436915delG	ENST00000428809.1	+	0	177																											CCCCTGGGACGGGGGCCTTGG	0.687													5	9	---	---	---	---					
