Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
XPOT	11260	broad.mit.edu	37	12	64827210	64827210	+	Missense_Mutation	SNP	T	T	G			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr12:64827210T>G	ENST00000332707.5	+	19	2808	c.2279T>G	c.(2278-2280)tTt>tGt	p.F760C		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	760	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		GTATCCCCGTTTTTACAACAG	0.368000													63	75					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128186	152128186	+	Silent	SNP	A	A	G			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr1:152128186A>G	ENST00000316073.3	-	3	1453	c.1389T>C	c.(1387-1389)taT>taC	p.Y463Y		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	463	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CTGTCTGACCATAGTGGGAAC	0.512000													10	962					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149523622	149523622	+	RNA	SNP	G	G	A			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr7:149523622G>A	ENST00000378016.2	+	0	14536							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGCCATCTGTGTGCAGGAGCC	0.682000													6	10					0	0	1	0	0
ZNF766	90321	broad.mit.edu	37	19	52793760	52793760	+	Missense_Mutation	SNP	G	G	T			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr19:52793760G>T	ENST00000439461.1	+	4	759	c.716G>T	c.(715-717)gGa>gTa	p.G239V	ZNF766_ENST00000593612.1_Missense_Mutation_p.G254V|ZNF766_ENST00000359102.4_Missense_Mutation_p.G254V|ZNF766_ENST00000599581.1_3'UTR|CTD-2525I3.5_ENST00000594865.1_RNA	NM_001010851.2	NP_001010851.1	Q5HY98	ZN766_HUMAN	zinc finger protein 766	239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	17				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		ATTCGTACAGGAGAGAAACCT	0.438000													5	35					0.0215528	0.0221686	1	1	0
DOCK2	1794	broad.mit.edu	37	5	169503024	169503024	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr5:169503024G>A	ENST00000256935.8	+	47	4882	c.4802G>A	c.(4801-4803)cGg>cAg	p.R1601Q	DOCK2_ENST00000540750.1_Missense_Mutation_p.R662Q|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.R1093Q	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1601	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCCATGACCGGATGGAGGAA	0.493000													4	84					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V|FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													10	156					0	0	1	0	0
GAS6	2621	broad.mit.edu	37	13	114535648	114535648	+	Silent	SNP	G	G	C			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr13:114535648G>C	ENST00000357389.3	-	9	1193	c.1041C>G	c.(1039-1041)acC>acG	p.T347T	GAS6_ENST00000480426.1_5'UTR|GAS6-AS1_ENST00000458001.1_RNA|GAS6_ENST00000450766.1_Silent_p.T31T|GAS6_ENST00000418959.3_Silent_p.T5T|GAS6_ENST00000327773.6_Silent_p.T304T|GAS6_ENST00000355761.4_Silent_p.T250T			Q14393	GAS6_HUMAN	growth arrest-specific 6	347	Laminin G-like 1.				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)|ovary(1)	5	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				GGATCACGGGGGTCCCACTGA	0.617000													9	72					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													3	4					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													3	4					1	1	1	1	0
ANKRD32	84250	broad.mit.edu	37	5	94030832	94030832	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr5:94030832G>A	ENST00000265140.5	+	21	3411	c.2992G>A	c.(2992-2994)Gaa>Aaa	p.E998K	ANKRD32_ENST00000493934.1_Intron	NM_032290.3	NP_115666.2	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	998										NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	13		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		AAGTCATAAAGAAACCACCAG	0.343000													6	32					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													4	47					0.00909568	0.00963072	1	1	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													4	49					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14859445	14859445	+	Silent	SNP	G	G	A			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr9:14859445G>A	ENST00000380881.4	-	5	1182	c.367C>T	c.(367-369)Ctg>Ttg	p.L123L	FREM1_ENST00000422223.2_Silent_p.L123L|FREM1_ENST00000380880.3_Silent_p.L123L			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	123					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TAGACCCACAGGATAAAAGTT	0.408000													46	79					0	0	1	0	0
NT5C3A	51251	broad.mit.edu	37	7	33055412	33055412	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr7:33055412G>A	ENST00000396152.2	-	9	964	c.662C>T	c.(661-663)aCa>aTa	p.T221I	AVL9_ENST00000404479.1_Intron|NT5C3A_ENST00000381626.2_Missense_Mutation_p.T209I|NT5C3A_ENST00000409467.1_Missense_Mutation_p.T209I|NT5C3A_ENST00000405342.1_Missense_Mutation_p.T221I|NT5C3A_ENST00000242210.7_Missense_Mutation_p.T260I	NM_016489.12	NP_057573.2			5'-nucleotidase, cytosolic IIIA																		GAAATATTCTGTATTCCTCAA	0.368000													3	27					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53028862	53028862	+	Missense_Mutation	SNP	G	G	T			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr8:53028862G>T	ENST00000276480.7	-	25	3659	c.2976C>A	c.(2974-2976)agC>agA	p.S992R		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	992						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGTCAGCAAGGCTTGAAATGA	0.463000													11	57					3.86212e-05	4.21322e-05	1	1	0
IGSF9B	22997	broad.mit.edu	37	11	133790063	133790063	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr11:133790063C>T	ENST00000321016.8	-	18	3787	c.3557G>A	c.(3556-3558)cGc>cAc	p.R1186H	IGSF9B_ENST00000533871.2_Missense_Mutation_p.R1186H			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1186	Pro-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GGGCTCGGCGCGCCTGGCCTG	0.721000													29	52					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103230092	103230092	+	Missense_Mutation	SNP	C	C	T			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr7:103230092C>T	ENST00000424685.2	-	28	4255	c.4096G>A	c.(4096-4098)Gaa>Aaa	p.E1366K	RELN_ENST00000428762.1_Missense_Mutation_p.E1366K|RELN_ENST00000343529.5_Missense_Mutation_p.E1366K			P78509	RELN_HUMAN	reelin	1366					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GTCCATTCTTCAAAGTCCCCT	0.458000													51	91					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				22	41					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	66					0	0	1	0	0
ZMYND11	10771	broad.mit.edu	37	10	292819	292819	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr10:292819G>A	ENST00000397962.3	+	11	1492	c.1064G>A	c.(1063-1065)cGt>cAt	p.R355H	ZMYND11_ENST00000381591.1_Missense_Mutation_p.R355H|ZMYND11_ENST00000381584.1_Missense_Mutation_p.R338H|ZMYND11_ENST00000381604.4_Missense_Mutation_p.R315H|ZMYND11_ENST00000402736.1_Missense_Mutation_p.R324H|ZMYND11_ENST00000509513.2_Missense_Mutation_p.R354H|ZMYND11_ENST00000535374.1_Missense_Mutation_p.R150H|ZMYND11_ENST00000558098.2_Missense_Mutation_p.R355H|ZMYND11_ENST00000381607.4_Missense_Mutation_p.R261H|ZMYND11_ENST00000403354.1_Missense_Mutation_p.R275H|ZMYND11_ENST00000473115.1_3'UTR|ZMYND11_ENST00000545619.1_Missense_Mutation_p.R235H|ZMYND11_ENST00000381602.4_Missense_Mutation_p.R315H|ZMYND11_ENST00000602682.1_Missense_Mutation_p.R270H|ZMYND11_ENST00000397959.3_Missense_Mutation_p.R270H|ZMYND11_ENST00000309776.4_Missense_Mutation_p.R315H			Q15326	ZMY11_HUMAN	zinc finger, MYND-type containing 11	315					cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	24		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CTGCATCAGCGTTTCCTACGA	0.478000													5	13					0	0	1	0	0
ANKRD36BP2	0	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													3	3	---	---	---	---					
RP11-167H9.4	0	broad.mit.edu	37	3	149769296	149769296	+	RNA	DEL	C	C	-	rs59377959		TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr3:149769296delC	ENST00000487840.1	+	0	46																											TTCCTGGTGTCtttttttttt	0.463													9	45	---	---	---	---					
TRBV6-8	0	broad.mit.edu	37	7	142124496	142124497	+	RNA	INS	-	-	G	rs72463875		TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr7:142124496_142124497insG	ENST00000390376.2	-	0	49																											AATCCACGCAAGGGCCCTGCCC	0.614													7	78	---	---	---	---					
KRTAP5-10	387273	broad.mit.edu	37	11	71276909	71276910	+	In_Frame_Ins	INS	-	-	GGCTGTGGCTCCTGTGGGGGCTCCAAGGGA	rs36179995		TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr11:71276909_71276910insGGCTGTGGCTCCTGTGGGGGCTCCAAGGGA	ENST00000398531.1	+	1	301_302	c.276_277insGGCTGTGGCTCCTGTGGGGGCTCCAAGGGA	c.(274-279)gggctg>ggGGCTGTGGCTCCTGTGGGGGCTCCAAGGGAgctg	p.92_93GL>GAVAPVGAPREL	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	92	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						GCTCCAAGGGGGGCTGTGGCTC	0.678													13	233	---	---	---	---					
HERC2P2	0	broad.mit.edu	37	15	23331163	23331163	+	RNA	DEL	A	A	-			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr15:23331163delA	ENST00000560464.1	-	0	908																											AATAAATACTAAAAAAAAAAA	0.368													3	4	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93540316	93540316	+	Frame_Shift_Del	DEL	A	A	-			TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr15:93540316delA	ENST00000394196.4	+	29	4793	c.3725delA	c.(3724-3726)gafs	p.E1242fs	CHD2_ENST00000557381.1_Frame_Shift_Del_p.E1242fs	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1242					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GACCCTGAAGAAAAAAAAAAG	0.348													7	64	---	---	---	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	In_Frame_Del	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	rs483929	by1000genomes	TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	ENST00000398472.1	-	1	742_798	c.255_311delCCCACTCTGCTGTCAGACCACCTGCCACCCCAGCTGTGGTATGTCCAGCTGCTGCCG	c.(253-312)cgt>cg	p.RPLCCQTTCHPSCGMSSCCR85del				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	85	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].		Missing (in allele KAP4.10).			keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													97	30	---	---	---	---					
IGLV5-48	0	broad.mit.edu	37	22	22707452	22707453	+	RNA	INS	-	-	T	rs113847228	by1000genomes	TCGA-KS-A4I3-01A-11D-A257-08	TCGA-KS-A4I3-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9a14b60c-27c5-4e97-908f-e727044d75b1	bbddd5b2-b8b0-4d56-97c3-5a2aefb16746	g.chr22:22707452_22707453insT	ENST00000390293.1	+	0	46																											ATATGCCTGTGTTCCAGGTTCC	0.500													13	102	---	---	---	---					
