Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TUBB8P7	0	broad.mit.edu	37	16	90161852	90161852	+	RNA	SNP	A	A	G	rs11076666	by1000genomes	TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr16:90161852A>G	ENST00000567960.1	+	0	588				TUBB8P7_ENST00000564451.1_RNA																							TAGAAAACGCAGATGAGACCT	0.498000													3	48					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	A	G	rs60608267	by1000genomes	TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr12:132547093A>G	ENST00000333577.4	+	48	8398	c.8289A>G	c.(8287-8289)caA>caG	p.Q2763Q	EP400_ENST00000389562.2_Silent_p.Q2726Q|EP400_ENST00000389561.2_Silent_p.Q2727Q|EP400_ENST00000332482.4_Silent_p.Q2690Q|EP400_ENST00000330386.6_Silent_p.Q2646Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.567000													16	87					0	0	1	0	0
MT-ND4L	4539	broad.mit.edu	37	MT	10608	10608	+	Missense_Mutation	SNP	A	A	C			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chrM:10608A>C	ENST00000361335.1	+	1	139	c.139A>C	c.(139-141)Ata>Cta	p.I47L						mitochondrially encoded NADH dehydrogenase 4L											breast(1)|endometrium(2)|kidney(2)	5						TAGCTACTCTCATAACCCTCA	0.468000													2	0					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000330386.6_Silent_p.Q2644Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													14	83					0	0	1	0	0
FAM66D	0	broad.mit.edu	37	8	11986096	11986096	+	RNA	SNP	T	T	A			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr8:11986096T>A	ENST00000434078.2	+	0	608					NR_027425.1																						CAACTGTTCCTAAGCTTGCTT	0.502000													3	40					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16258731	16258731	+	Missense_Mutation	SNP	A	A	G			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr1:16258731A>G	ENST00000375759.3	+	11	6200	c.5996A>G	c.(5995-5997)aAg>aGg	p.K1999R		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1999					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CAAGGGAAAAAGGGAAAAAAT	0.567000													3	36					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32164797	32164797	+	Missense_Mutation	SNP	G	G	A			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr6:32164797G>A	ENST00000375023.3	-	28	5243	c.5105C>T	c.(5104-5106)aCc>aTc	p.T1702I	NOTCH4_ENST00000443903.2_Missense_Mutation_p.T111I	NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1702					cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						CAAGGGTGTGGTCCCGTCCTC	0.602000													13	75					0	0	1	0	0
CYP2D6	1565	broad.mit.edu	37	22	42523567	42523567	+	Missense_Mutation	SNP	T	T	C	rs61736517		TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr22:42523567T>C	ENST00000360608.5	-	7	1169	c.1055A>G	c.(1054-1056)cAc>cGc	p.H352R	NDUFA6-AS1_ENST00000439129.1_RNA|CYP2D6_ENST00000389970.3_Missense_Mutation_p.H352R|NDUFA6-AS1_ENST00000416037.1_RNA|CYP2D6_ENST00000359033.4_Missense_Mutation_p.H301R	NM_000106.5	NP_000097.3	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	352							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GTAGGGCATGTGAGCCTGGTC	0.592000													4	28					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212589892	212589892	+	Missense_Mutation	SNP	C	C	A			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr2:212589892C>A	ENST00000342788.4	-	6	960	c.650G>T	c.(649-651)tGt>tTt	p.C217F	ERBB4_ENST00000436443.1_Missense_Mutation_p.C217F|ERBB4_ENST00000484474.1_5'UTR|ERBB4_ENST00000402597.1_Missense_Mutation_p.C217F	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	217	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCTGCCGTCACATTGTTCTGC	0.512000										TSP Lung(8;0.080)			3	40					0.00024832	0.00024832	1	1	0
IGHV4OR15-8	0	broad.mit.edu	37	15	22473333	22473333	+	RNA	SNP	A	A	G			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr15:22473333A>G	ENST00000557788.2	-	0	20																											CCAGGAGGAGAAAGAACCACA	0.512000													4	46					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186295347	186295347	+	Missense_Mutation	SNP	T	T	A			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr1:186295347T>A	ENST00000367478.3	-	41	6206	c.5910A>T	c.(5908-5910)gaA>gaT	p.E1970D		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	1970					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		catcatcatcttcctcatcct	0.423000			T	NTRK1	papillary thyroid								3	15					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				9	13					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1947077	1947078	+	Frame_Shift_Ins	INS	-	-	T			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr2:1947077_1947078insT	ENST00000399161.2	-	9	928_929	c.181_182insA	c.(181-183)aaafs	p.K61fs	MYT1L_ENST00000428368.2_Frame_Shift_Ins_p.K61fs	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	61					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TTGTGTTTTTCTTTTTTTCGCC	0.406													2	4	---	---	---	---					
CXXC4	80319	broad.mit.edu	37	4	105412465	105412467	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr4:105412465_105412467delGCC	ENST00000394767.2	-	2	943_945	c.493_495delGGC	c.(493-495)del	p.G165del	CXXC4_ENST00000426831.1_5'UTR|CXXC4_ENST00000466963.1_Intron|AC004053.1_ENST00000500179.1_RNA	NM_025212.2	NP_079488.2	Q9H2H0	CXXC4_HUMAN	CXXC finger protein 4	0	Interaction with DVL1 (By similarity).				negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		TGGTCCTgctgccgccgccgccg	0.695													7	173	---	---	---	---					
RP11-244K5.8	0	broad.mit.edu	37	6	150225766	150225766	+	RNA	DEL	T	T	-			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr6:150225766delT	ENST00000606915.1	+	0	889				RP11-244K5.1_ENST00000446954.1_RNA|RP11-244K5.1_ENST00000605899.1_RNA	NR_045126.1																						CTTGCATGGCTTTTCCCCGGA	0.542													2	4	---	---	---	---					
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	CTCCTA	-	rs3812754	byFrequency	TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr11:12316384_12316389delCTCCTA	ENST00000256186.2	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)cca>c	p.PPT469del		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	469	Poly-Pro.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding	p.T471delT(2)		breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cctcctcctcctcctACAGCGGGAGG	0.573													14	16	---	---	---	---					
ZNF688	146542	broad.mit.edu	37	16	30581350	30581351	+	Frame_Shift_Ins	INS	-	-	C			TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr16:30581350_30581351insC	ENST00000223459.6	-	3	1821_1822	c.717_718insG	c.(715-720)ggggcgfs	p.A240fs	ZNF688_ENST00000395219.1_Frame_Shift_Ins_p.A226fs	NM_145271.3	NP_660314.1	P0C7X2	ZN688_HUMAN	zinc finger protein 688	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)	8						CGGCCCCGCCGCCCCCCGGAGC	0.708													11	65	---	---	---	---					
KANK3	256949	broad.mit.edu	37	19	8398950	8398961	+	In_Frame_Del	DEL	TCGCTGTCGCCA	TCGCTGTCGCCA	-	rs111751275		TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr19:8398950_8398961delTCGCTGTCGCCA	ENST00000330915.3	-	5	1532_1543	c.1467_1478delTGGCGACAGCGA	c.(1465-1479)gag>ga	p.DGDSE489del	KANK3_ENST00000593649.1_In_Frame_Del_p.DGDSE489del	NM_198471.2	NP_940873.2	Q6NY19	KANK3_HUMAN	KN motif and ankyrin repeat domains 3	489								p.D489_S492delDGDS(2)		breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						GCCACCGTTCTCGCTGTCGCCATCGCTGTCGC	0.717													4	4	---	---	---	---					
IGLV3-12	0	broad.mit.edu	37	22	23114749	23114749	+	RNA	DEL	T	T	-	rs74864698		TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chr22:23114749delT	ENST00000390313.2	+	0	55																											CATCCTCTCCTTTTTTTTTTT	0.498													2	4	---	---	---	---					
EDA	1896	broad.mit.edu	37	X	68836236	68836237	+	Frame_Shift_Ins	INS	-	-	G	rs41539891		TCGA-KS-A4I7-01A-11D-A257-08	TCGA-KS-A4I7-11A-11D-A25A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1653ae34-a8b7-4e15-9f41-abcffdd739b7	058e791c-92fb-4781-a27a-719d1f10755c	g.chrX:68836236_68836237insG	ENST00000374552.4	+	1	326_327	c.84_85insG	c.(82-87)gggggcfs	p.GG28fs	EDA_ENST00000525810.1_Frame_Shift_Ins_p.GG28fs|EDA_ENST00000374553.2_Frame_Shift_Ins_p.GG28fs|EDA_ENST00000527388.1_Frame_Shift_Ins_p.GG28fs|EDA_ENST00000502251.1_3'UTR|EDA_ENST00000338901.3_Frame_Shift_Ins_p.GG28fs|EDA_ENST00000524573.1_Frame_Shift_Ins_p.GG28fs	NM_001399.4	NP_001390.1	Q92838	EDA_HUMAN	ectodysplasin A	28					cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|urinary_tract(1)	14						GCGGGTGTGGCGGGGCCCCTGC	0.708													15	74	---	---	---	---					
