Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARSJ	79642	broad.mit.edu	37	4	114899926	114899926	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr4:114899926C>A	ENST00000315366.7	-	1	931	c.65G>T	c.(64-66)gGa>gTa	p.G22V	ARSJ_ENST00000541197.1_Missense_Mutation_p.G22V|ARSJ_ENST00000503013.2_5'UTR	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	22						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		TAGCATCTTTCCAGGACAGAC	0.607000													138	15					7.39696e-70	8.68011e-70	1	1	0
CRTC2	200186	broad.mit.edu	37	1	153925843	153925843	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:153925843G>A	ENST00000368633.1	-	6	633	c.506C>T	c.(505-507)aCa>aTa	p.T169I	CRTC2_ENST00000476883.1_5'UTR|CRTC2_ENST00000368630.3_Intron	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	169					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GTCAGAGCTTGTCCTATGGGG	0.592000													5	57					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31434762	31434762	+	Silent	SNP	C	C	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr16:31434762C>A	ENST00000389202.2	+	25	2998	c.2949C>A	c.(2947-2949)gtC>gtA	p.V983V		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	983				V -> A (in Ref. 3; AAB60638).	cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGGATGTGGTCATGGAGGCCC	0.542000													106	43					1.73998e-50	2.02119e-50	1	1	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651251	1651251	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr11:1651251G>A	ENST00000399676.2	+	1	219	c.181G>A	c.(181-183)Ggc>Agc	p.G61S		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	61						keratin filament		p.G61S(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		atgtggctccggctgCTGTGT	0.682000													92	34					0	0	1	0	0
OR4C12	283093	broad.mit.edu	37	11	50003362	50003362	+	Missense_Mutation	SNP	T	T	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr11:50003362T>G	ENST00000335238.4	-	1	709	c.676A>C	c.(676-678)Aat>Cat	p.N226H		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						TCCAAGCTATTGTTCTTTAAA	0.408000													7	42					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	115006917	115006917	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:115006917C>G	ENST00000358465.2	-	2	703	c.620G>C	c.(619-621)aGc>aCc	p.S207T	TRIM33_ENST00000369543.2_Missense_Mutation_p.S207T	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	207					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCAGAACTGCTAGGAGCTTC	0.358000			T	RET	papillary thyroid								6	11					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50216636	50216636	+	Silent	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr22:50216636G>A	ENST00000216267.8	-	1	1816	c.1330C>T	c.(1330-1332)Ctg>Ttg	p.L444L	BRD1_ENST00000404034.1_Silent_p.L444L|BRD1_ENST00000542442.1_Silent_p.L83L|BRD1_ENST00000342989.5_5'UTR|BRD1_ENST00000457780.2_Silent_p.L444L|BRD1_ENST00000404760.1_Silent_p.L444L|BRD1_ENST00000459821.1_5'UTR	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	444					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		ACGGTCGGCAGGACCGCGCAG	0.572000													56	117					0	0	1	0	0
ZBTB3	79842	broad.mit.edu	37	11	62520200	62520200	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr11:62520200C>G	ENST00000394807.3	-	2	1212	c.1087G>C	c.(1087-1089)Gat>Cat	p.D363H		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	363					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						GTCTCTTCATCAGAGATCACA	0.577000													27	35					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81239693	81239693	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:81239693C>A	ENST00000552864.1	-	4	501	c.299G>T	c.(298-300)aGt>aTt	p.S100I		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	100					exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						GTGGCCTTCACTAGCTGCAAA	0.408000													18	0					9.16793e-09	1.00411e-08	1	1	0
DCP1A	55802	broad.mit.edu	37	3	53321609	53321609	+	Missense_Mutation	SNP	G	G	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:53321609G>T	ENST00000607628.1	-	10	1853	c.1744C>A	c.(1744-1746)Cac>Aac	p.H582N	DCP1A_ENST00000606822.1_Missense_Mutation_p.H544N|DCP1A_ENST00000480258.1_5'UTR|DCP1A_ENST00000294241.6_Missense_Mutation_p.H580N	NM_018403.5	NP_060873.4	Q9NPI6	DCP1A_HUMAN	decapping mRNA 1A	580					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		CATAGGTTGTGGTTGTCTTTG	0.433000													17	32					3.32936e-07	3.61204e-07	1	1	0
RP11-622K12.1	0	broad.mit.edu	37	X	56763592	56763592	+	RNA	SNP	G	G	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chrX:56763592G>T	ENST00000374922.4	+	0	468					NR_015367.2																						TAAAACATCTGCAGACCAAAT	0.308000													3	14					0.004672	0.00479714	1	1	0
NUP93	9688	broad.mit.edu	37	16	56792513	56792513	+	Silent	SNP	G	G	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr16:56792513G>T	ENST00000569842.1	+	3	339	c.243G>T	c.(241-243)ctG>ctT	p.L81L	NUP93_ENST00000308159.5_Silent_p.L81L			Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	81					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TGGAGAGTCTGAGTGCAGCCA	0.517000													11	38					0.000673444	0.000704055	1	1	0
KCNT2	343450	broad.mit.edu	37	1	196397292	196397292	+	Silent	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:196397292C>T	ENST00000367433.5	-	10	1028	c.927G>A	c.(925-927)ctG>ctA	p.L309L	KCNT2_ENST00000294725.8_Silent_p.L309L|KCNT2_ENST00000367431.4_Silent_p.L309L|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Intron			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	309						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						AATCAATCTTCAGTGAGCTGA	0.393000													4	35					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628299	29628299	+	Missense_Mutation	SNP	A	A	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr20:29628299A>G	ENST00000278882.3	+	6	681	c.301A>G	c.(301-303)Agt>Ggt	p.S101G	FRG1B_ENST00000358464.4_Missense_Mutation_p.S101G|FRG1B_ENST00000439954.2_Missense_Mutation_p.S106G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGAAGCAAAAAGTAAAACAGC	0.363000													5	95					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50964799	50964799	+	Splice_Site	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr19:50964799G>A	ENST00000357701.5	+	25	2983	c.2931_splice	c.e25-1	p.E978_splice		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	978	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CCCACACTAGGAGTGGTTCAA	0.512000											OREG0025636	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	14					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33999485	33999485	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:33999485C>T	ENST00000373381.4	-	63	10078	c.9902G>A	c.(9901-9903)cGt>cAt	p.R3301H		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3157						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTTTTGACAACGGAAGAGGAC	0.562000													17	11					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	54					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121947777	121947777	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:121947777C>T	ENST00000377069.4	-	11	1553	c.1147G>A	c.(1147-1149)Gcc>Acc	p.A383T	KDM2B_ENST00000377071.4_Missense_Mutation_p.A414T|KDM2B_ENST00000538046.2_Missense_Mutation_p.A324T|KDM2B_ENST00000536437.1_Missense_Mutation_p.A297T	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	414					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						TGATCACAGGCCTCCTCCTCC	0.627000													27	4					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95514946	95514946	+	RNA	SNP	C	C	T	rs143937878	by1000genomes	TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:95514946C>T	ENST00000432432.2	-	0	711					NR_040113.1													p.R201Q(1)									ACTACTGTACCGTCTCAGCCT	0.308000													4	117					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152278956	152278956	+	Silent	SNP	G	G	A	rs137870179	byFrequency	TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:152278956G>A	ENST00000368799.1	-	3	8441	c.8406C>T	c.(8404-8406)caC>caT	p.H2802H	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2802	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.H2802Q(1)		autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGAATGCTCGTGGTGGTACC	0.597000									Ichthyosis				17	763					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977358	29977358	+	RNA	SNP	T	T	C	rs146982767	by1000genomes	TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:29977358T>C	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							GATTTGTTCATGCCTTCCCTT	0.448000													4	39					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134628401	134628401	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr10:134628401C>G	ENST00000368586.5	-	51	7235	c.7135G>C	c.(7135-7137)Gag>Cag	p.E2379Q	TTC40_ENST00000263170.5_Missense_Mutation_p.E540Q	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	540										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						CTTCTTCCCTCCTTTTTCACG	0.577000													7	129					0	0	1	0	0
POLR3D	661	broad.mit.edu	37	8	22106726	22106726	+	Silent	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr8:22106726C>G	ENST00000397802.4	+	6	1040	c.825C>G	c.(823-825)ctC>ctG	p.L275L	POLR3D_ENST00000306433.4_Silent_p.L275L			P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	275					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	13				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CAGACACCCTCCCTGGCCAGC	0.597000													9	49					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50216637	50216637	+	Silent	SNP	G	G	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr22:50216637G>T	ENST00000216267.8	-	1	1815	c.1329C>A	c.(1327-1329)gtC>gtA	p.V443V	BRD1_ENST00000404034.1_Silent_p.V443V|BRD1_ENST00000542442.1_Silent_p.V82V|BRD1_ENST00000342989.5_5'UTR|BRD1_ENST00000457780.2_Silent_p.V443V|BRD1_ENST00000404760.1_Silent_p.V443V|BRD1_ENST00000459821.1_5'UTR	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	443					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CGGTCGGCAGGACCGCGCAGG	0.567000													56	119					7.34454e-26	8.44623e-26	1	1	0
TMTC4	84899	broad.mit.edu	37	13	101266664	101266664	+	Silent	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr13:101266664G>A	ENST00000342624.5	-	16	2115	c.1857C>T	c.(1855-1857)caC>caT	p.H619H	TMTC4_ENST00000376234.3_Silent_p.H600H|TMTC4_ENST00000328767.5_Silent_p.H489H	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	600						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AGGCATCCACGTGGCGATTGA	0.413000													10	93					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35545400	35545400	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr20:35545400G>C	ENST00000262878.4	-	8	1104	c.905C>G	c.(904-906)tCt>tGt	p.S302C	SAMHD1_ENST00000373694.5_Missense_Mutation_p.S87C	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	302	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity	p.S302Y(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				TCTTTTATTAGATACTATCTC	0.363000													18	25					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47363917	47363917	+	Missense_Mutation	SNP	A	A	G	rs138128932	by1000genomes	TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr18:47363917A>G	ENST00000285039.7	-	37	5407	c.5108T>C	c.(5107-5109)gTc>gCc	p.V1703A	RP11-886H22.1_ENST00000590532.2_Missense_Mutation_p.V26A|MYO5B_ENST00000324581.6_Missense_Mutation_p.V818A|MYO5B_ENST00000592688.1_Missense_Mutation_p.V273A|SCARNA17_ENST00000589499.1_RNA	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1703	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.V1703A(5)		NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CCAAGAGCAGACGTCCTTCCG	0.527000													3	31					0	0	1	0	0
SDHA	6389	broad.mit.edu	37	5	240531	240531	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr5:240531C>G	ENST00000264932.6	+	11	1606	c.1491C>G	c.(1489-1491)gaC>gaG	p.D497E	SDHA_ENST00000510361.1_Missense_Mutation_p.D449E|SDHA_ENST00000504309.1_Missense_Mutation_p.D497E	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	497					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	TGAATCTTGACAAATTGAGAT	0.428000									Familial Paragangliomas				4	73					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51889956	51889956	+	Nonsense_Mutation	SNP	G	G	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:51889956G>T	ENST00000371117.3	-	32	4927	c.4652C>A	c.(4651-4653)tCa>tAa	p.S1551*	PKHD1_ENST00000340994.4_Nonsense_Mutation_p.S1551*	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1551	IPT/TIG 10.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					ATAAAAAACTGACAGGTAGTG	0.403000													10	51					0.0581538	0.0586639	1	1	0
SLC35D3	340146	broad.mit.edu	37	6	137243603	137243603	+	Missense_Mutation	SNP	T	T	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:137243603T>G	ENST00000331858.4	+	1	202	c.37T>G	c.(37-39)Tcg>Gcg	p.S13A		NM_001008783.1	NP_001008783.1	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	13					carbohydrate transport	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	13	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		GCTGGGCATCTCGGTGGCCAT	0.701000													4	14					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195511815	195511815	+	Silent	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:195511815G>A	ENST00000463781.3	-	2	7095	c.6636C>T	c.(6634-6636)acC>acT	p.T2212T	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Silent_p.T2212T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1001					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.T2212T(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGGGCTGGTGACAGGAA	0.602000													4	32					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148809307	148809307	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr7:148809307C>G	ENST00000378061.2	-	3	358	c.226G>C	c.(226-228)Gat>Cat	p.D76H	ZNF425_ENST00000484196.1_5'UTR	NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	76	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTTGTTTTATCTAAGCATCCC	0.398000													4	73					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272749	52272749	+	Missense_Mutation	SNP	A	A	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr19:52272749A>T	ENST00000598776.1	+	2	1610	c.838A>T	c.(838-840)Att>Ttt	p.I280F	FPR2_ENST00000340023.6_Missense_Mutation_p.I280F|FPR2_ENST00000598953.1_Missense_Mutation_p.I280F	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	280					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						GTACAAAATCATTGACATCCT	0.498000													13	45					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16327903	16327903	+	Missense_Mutation	SNP	C	C	A	rs3817753		TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:16327903C>A	ENST00000244769.4	-	8	1575	c.639G>T	c.(637-639)caG>caT	p.Q213H	ATXN1_ENST00000436367.1_Missense_Mutation_p.Q213H	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	213	Poly-Gln.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				gctgctgctgctgctgatgct	0.667000													5	33					0.014758	0.0150192	1	1	0
CYP1A2	1544	broad.mit.edu	37	15	75042815	75042815	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr15:75042815C>T	ENST00000343932.4	+	2	799	c.736C>T	c.(736-738)Cct>Tct	p.P246S		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	246					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	TCGCTACCTGCCTAACCCTGC	0.552000													33	116					0	0	1	0	0
CAPZB	832	broad.mit.edu	37	1	19712043	19712043	+	Silent	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:19712043C>T	ENST00000264203.3	-	4	742	c.249G>A	c.(247-249)aaG>aaA	p.K83K	CAPZB_ENST00000375144.1_Silent_p.K45K|CAPZB_ENST00000375142.1_Silent_p.K57K|CAPZB_ENST00000401084.2_Silent_p.K57K|CAPZB_ENST00000482808.1_5'UTR|CAPZB_ENST00000264202.6_Silent_p.K57K|CAPZB_ENST00000433834.1_Silent_p.K86K			P47756	CAPZB_HUMAN	capping protein (actin filament) muscle Z-line, beta	57					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement	cytosol|F-actin capping protein complex|WASH complex	actin binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	7		Colorectal(325;3.93e-05)|Renal(390;0.000147)|all_lung(284;0.000169)|Lung NSC(340;0.000202)|Breast(348;0.000496)|Ovarian(437;0.00428)|Myeloproliferative disorder(586;0.0262)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Kidney(64;8.63e-06)|BRCA - Breast invasive adenocarcinoma(304;4.06e-05)|KIRC - Kidney renal clear cell carcinoma(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000525)|STAD - Stomach adenocarcinoma(196;0.00779)|READ - Rectum adenocarcinoma(331;0.103)|Lung(427;0.173)		AAAGGTAATCCTTTCCCACCA	0.547000													20	27					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113748841	113748841	+	Silent	SNP	G	G	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr13:113748841G>T	ENST00000397030.1	+	27	3103	c.3066G>T	c.(3064-3066)acG>acT	p.T1022T	MCF2L_ENST00000423482.2_Silent_p.T987T|MCF2L_ENST00000421756.1_Silent_p.T993T|MCF2L_ENST00000442652.2_Silent_p.T1019T|MCF2L_ENST00000434480.2_Silent_p.T995T|MCF2L_ENST00000375604.2_Silent_p.T1046T|MCF2L_ENST00000375601.3_Silent_p.T993T|MCF2L_ENST00000535094.2_Silent_p.T989T|MCF2L_ENST00000375608.3_Silent_p.T1019T			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	1019					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				GGAGCAAAACGTCCCACTCAC	0.622000													5	39					0.000602214	0.000635364	1	1	0
GPR15	2838	broad.mit.edu	37	3	98251260	98251260	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:98251260G>A	ENST00000284311.3	+	1	518	c.383G>A	c.(382-384)aGt>aAt	p.S128N		NM_005290.1	NP_005281.1	P49685	GPR15_HUMAN	G protein-coupled receptor 15	128						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		ACTTGCATGAGTGTTGACCGC	0.522000													19	37					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656143	40656143	+	Silent	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:40656143G>A	ENST00000406785.1	-	2	1467	c.1278C>T	c.(1276-1278)gcC>gcT	p.A426A	SLC8A1_ENST00000542756.1_Silent_p.A426A|SLC8A1_ENST00000332839.4_Silent_p.A426A|SLC8A1_ENST00000542024.1_Silent_p.A426A|SLC8A1_ENST00000408028.2_Silent_p.A426A|SLC8A1_ENST00000406391.2_Silent_p.A426A|SLC8A1_ENST00000405269.1_Silent_p.A426A|SLC8A1_ENST00000403092.1_Silent_p.A426A|SLC8A1_ENST00000405901.3_Silent_p.A426A|SLC8A1_ENST00000402441.1_Silent_p.A426A			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	426	Calx-beta 1.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding	p.A426A(1)		NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TAATGGTAAGGGCCACAGTAC	0.438000													11	111					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578190	7578190	+	Missense_Mutation	SNP	T	T	G	rs121912666		TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr17:7578190T>G	ENST00000420246.2	-	6	791	c.659A>C	c.(658-660)tAt>tCt	p.Y220S	TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.Y220S|TP53_ENST00000455263.2_Missense_Mutation_p.Y220S|TP53_ENST00000445888.2_Missense_Mutation_p.Y220S|TP53_ENST00000269305.4_Missense_Mutation_p.Y220S|TP53_ENST00000413465.2_Missense_Mutation_p.Y220S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	220	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(278)|p.Y127C(24)|p.Y220S(12)|p.?(11)|p.0?(8)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.Y127S(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*2(1)|p.V218fs*26(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	4					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													4	108					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95514963	95514963	+	RNA	SNP	G	G	A	rs114749649	by1000genomes	TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:95514963G>A	ENST00000432432.2	-	0	694					NR_040113.1																						GCCTATCAACGGCATGTGTAC	0.328000													4	131					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78212571	78212571	+	RNA	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr15:78212571G>A	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCTGTGTCACGTGTGCGTTCA	0.572000													4	32					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135475715	135475715	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chrX:135475715G>A	ENST00000394143.1	+	18	8347	c.8056G>A	c.(8056-8058)Gcc>Acc	p.A2686T	GPR112_ENST00000394141.1_Missense_Mutation_p.A2481T|GPR112_ENST00000370652.1_Missense_Mutation_p.A2686T|GPR112_ENST00000287534.4_Missense_Mutation_p.A2439T|GPR112_ENST00000412101.1_Missense_Mutation_p.A2481T	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2686	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AGTTCACTGTGCCTTTTGGGA	0.358000													3	8					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5708651	5708651	+	Splice_Site	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:5708651C>G	ENST00000546188.1	-	21	2306	c.2236_splice	c.e21+1	p.M745_splice	ANO2_ENST00000327087.8_Splice_Site_p.M744_splice|ANO2_ENST00000356134.5_Splice_Site_p.M745_splice			Q9NQ90	ANO2_HUMAN	anoctamin 2	749						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GGTTCTCACTCATTTCCATGT	0.542000													18	204					0	0	1	0	0
IPO8	10526	broad.mit.edu	37	12	30834617	30834617	+	Missense_Mutation	SNP	A	A	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:30834617A>T	ENST00000256079.4	-	4	796	c.458T>A	c.(457-459)cTg>cAg	p.L153Q		NM_006390.3	NP_006381.2	O15397	IPO8_HUMAN	importin 8	153					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(16)|liver(1)|lung(22)|prostate(2)|skin(2)|urinary_tract(2)	52	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CAGTTGATACAGGCATAATAA	0.423000													14	86					0	0	1	0	0
ZXDB	158586	broad.mit.edu	37	X	57619818	57619818	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chrX:57619818G>A	ENST00000374888.1	+	1	1550	c.1337G>A	c.(1336-1338)cGg>cAg	p.R446Q		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	446	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						ATTCACCTGCGGAGTCACACC	0.488000													18	47					0	0	1	0	0
GPRC5A	0	broad.mit.edu	37	12	13061636	13061636	+	Silent	SNP	A	A	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:13061636A>G	ENST00000014914.5	+	2	1343	c.453A>G	c.(451-453)gaA>gaG	p.E151E	GPRC5A_ENST00000542056.1_Intron	NM_003979.3	NP_003970.1	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5, member A	151						cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	18		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	TCGCTATTGAATATATTGTCC	0.527000													204	131					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2537800	2537800	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:2537800C>G	ENST00000288709.6	-	8	850	c.610G>C	c.(610-612)Gag>Cag	p.E204Q	MMEL1_ENST00000378412.3_Missense_Mutation_p.E213Q|MMEL1_ENST00000502556.1_Intron	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	213					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		AGCTCCCACTCGAGTCCTGGG	0.657000													10	22					0	0	1	0	0
MTHFD2L	441024	broad.mit.edu	37	4	75065519	75065519	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr4:75065519G>C	ENST00000395759.2	+	4	487	c.460G>C	c.(460-462)Gat>Cat	p.D154H	MTHFD2L_ENST00000331145.6_Missense_Mutation_p.D96H|MTHFD2L_ENST00000433372.1_Missense_Mutation_p.D19H|MTHFD2L_ENST00000325278.6_Missense_Mutation_p.D96H	NM_001144978.1	NP_001138450.1	Q9H903	MTD2L_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	96					folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			central_nervous_system(1)|endometrium(1)|lung(4)|ovary(2)	8			all cancers(17;0.0101)|Lung(101;0.196)			AGACCACGTTGATGAGCGAAC	0.313000													17	39					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29365088	29365088	+	Silent	SNP	T	T	C	rs144790258	by1000genomes	TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:29365088T>C	ENST00000383555.2	+	1	673	c.612T>C	c.(610-612)atT>atC	p.I204I	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						CGGGGACAATTGCCATGGGCC	0.443000													6	133					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194181555	194181555	+	Silent	SNP	A	A	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:194181555A>G	ENST00000439040.1	-	4	848	c.57T>C	c.(55-57)atT>atC	p.I19I	ATP13A3_ENST00000256031.4_Silent_p.I19I			Q9H7F0	AT133_HUMAN	ATPase type 13A3	19					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TGTAACCATAAATCTCCTGCA	0.403000													14	104					0	0	1	0	0
CCDC115	84317	broad.mit.edu	37	2	131099731	131099731	+	Silent	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:131099731C>T	ENST00000437688.2	-	1	180	c.72G>A	c.(70-72)agG>agA	p.R24R	CCDC115_ENST00000259229.2_5'UTR|CCDC115_ENST00000409127.1_Silent_p.R24R			Q96NT0	CC115_HUMAN	coiled-coil domain containing 115	0						endosome|lysosome				central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	7	Colorectal(110;0.1)					CCACCTTCTTCCTTGTCACCC	0.627000													5	8					0	0	1	0	0
PRDM11	56981	broad.mit.edu	37	11	45203391	45203391	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr11:45203391C>G	ENST00000263765.4	+	3	425	c.176C>G	c.(175-177)aCg>aGg	p.T59R	PRDM11_ENST00000530656.1_Missense_Mutation_p.T59R|PRDM11_ENST00000424263.2_Missense_Mutation_p.T25R			Q9NQV5	PRD11_HUMAN	PR domain containing 11	59				KTEVCSPLRD -> NPS (in Ref. 1; AAF87244).						endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	26						GTGGTGAAGACGGAGGTCTGC	0.622000													33	7					0	0	1	0	0
TUBBP5	0	broad.mit.edu	37	9	141070116	141070116	+	RNA	SNP	G	G	A	rs142836124	by1000genomes	TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr9:141070116G>A	ENST00000503395.1	+	0	1196																		p.R77H(1)									GACTCTGTGCGCTCGGGGCCC	0.687000													4	81					0	0	1	0	0
CCDC66	285331	broad.mit.edu	37	3	56647723	56647723	+	Missense_Mutation	SNP	G	G	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:56647723G>T	ENST00000394672.3	+	11	1581	c.1511G>T	c.(1510-1512)cGt>cTt	p.R504L	CCDC66_ENST00000436465.2_Missense_Mutation_p.R504L|CCDC66_ENST00000326595.7_Missense_Mutation_p.R470L	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	504										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		GCACAGGAACGTGAAGAGATG	0.398000													39	41					9.8876e-21	1.11478e-20	1	1	0
ANKRD20A5P	0	broad.mit.edu	37	18	14184263	14184263	+	RNA	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr18:14184263G>A	ENST00000581935.1	+	0	952																				lung(3)	3						TACTTTTAAAGGAGCATTAAA	0.264000													5	20					0	0	1	0	0
AGAP5	729092	broad.mit.edu	37	10	75457378	75457378	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr10:75457378C>T	ENST00000443782.2	-	1	261	c.136G>A	c.(136-138)Gct>Act	p.A46T	AGAP5_ENST00000374094.4_Missense_Mutation_p.A46T|RP11-464F9.1_ENST00000399449.3_RNA			A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 5	46					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(5)|skin(1)	12						ACAGCAGCAGCCATGGGCGCT	0.582000													29	119					0	0	1	0	0
HIST1H2AB	8335	broad.mit.edu	37	6	26033563	26033563	+	Silent	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:26033563G>A	ENST00000259791.2	-	1	233	c.234C>T	c.(232-234)cgC>cgT	p.R78R		NM_003513.2	NP_003504.2	P04908	H2A1B_HUMAN	histone cluster 1, H2ab	78					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8						GCGGGATGATGCGGGTCTTCT	0.622000													34	106					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234847659	234847659	+	Nonsense_Mutation	SNP	C	C	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:234847659C>A	ENST00000324695.4	+	5	406	c.366C>A	c.(364-366)tgC>tgA	p.C122*	TRPM8_ENST00000409625.1_Nonsense_Mutation_p.C45*|TRPM8_ENST00000355722.4_Nonsense_Mutation_p.C72*|TRPM8_ENST00000433712.2_5'UTR	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	122						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GTCTGTCCTGCGACACGGACG	0.547000													54	27					3.16986e-14	3.53917e-14	1	1	0
SNTA1	6640	broad.mit.edu	37	20	31996508	31996508	+	Splice_Site	SNP	A	A	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr20:31996508A>T	ENST00000217381.2	-	7	1695	c.1425_splice	c.e7+1	p.I475_splice		NM_003098.2	NP_003089.1	Q13424	SNTA1_HUMAN	syntrophin, alpha 1	475	SU.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			breast(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|stomach(1)|urinary_tract(1)	13						CTCACTCACGATCTCGCCTTC	0.622000													6	226					0	0	1	0	0
AZI1	22994	broad.mit.edu	37	17	79180597	79180597	+	Silent	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr17:79180597C>T	ENST00000269392.4	-	5	709	c.462G>A	c.(460-462)ccG>ccA	p.P154P	AZI1_ENST00000374782.3_Silent_p.P154P|AZI1_ENST00000575907.1_Silent_p.P154P|AZI1_ENST00000450824.2_Silent_p.P154P	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	154					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CTTTCCTCCGCGGGCCCGCTG	0.632000													9	72					0	0	1	0	0
RLIM	51132	broad.mit.edu	37	X	73811853	73811853	+	Missense_Mutation	SNP	A	A	C			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chrX:73811853A>C	ENST00000332687.6	-	4	1515	c.1297T>G	c.(1297-1299)Tca>Gca	p.S433A	RLIM_ENST00000349225.2_Missense_Mutation_p.S433A	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	433	Ser-rich.				random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTTCGATTTGAGACTGAGCCA	0.458000													28	12					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52320720	52320720	+	Missense_Mutation	SNP	T	T	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr8:52320720T>A	ENST00000356297.4	-	17	3564	c.3464A>T	c.(3463-3465)gAc>gTc	p.D1155V	PXDNL_ENST00000543296.1_Missense_Mutation_p.D1155V	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1155					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AACTCTGAAGTCAACATATGG	0.433000													24	85					0	0	1	0	0
RP11-262H14.1	0	broad.mit.edu	37	9	66459863	66459863	+	RNA	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr9:66459863G>A	ENST00000424345.1	+	0	123																											tttcctggatggtgttgatgc	0.363000													3	7					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109398713	109398713	+	Missense_Mutation	SNP	A	A	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:109398713A>G	ENST00000283195.6	+	27	9016	c.8890A>G	c.(8890-8892)Aca>Gca	p.T2964A		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2964	RanBD1 4.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TCTTTGGCATACAATGAAGAA	0.373000													20	26					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195511283	195511283	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:195511283C>T	ENST00000463781.3	-	2	7627	c.7168G>A	c.(7168-7170)Gct>Act	p.A2390T	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.A2390T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	148					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.A2390T(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GCTGAGGAAGCGTCGGTGACA	0.592000													4	31					0	0	1	0	0
TMEM185B	79134	broad.mit.edu	37	2	120980196	120980196	+	Silent	SNP	G	G	C			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:120980196G>C	ENST00000426077.2	-	1	788	c.357C>G	c.(355-357)ctC>ctG	p.L119L		NM_024121.2	NP_077026.2	Q9H7F4	T185B_HUMAN	transmembrane protein 185B	119						integral to membrane											ACACGAAGAAGAGAGGCATGA	0.612000													7	4					0	0	1	0	0
BPIFC	254240	broad.mit.edu	37	22	32843231	32843231	+	Translation_Start_Site	SNP	G	G	C			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr22:32843231G>C	ENST00000534972.1	-	0	467				BPIFC_ENST00000397452.1_Missense_Mutation_p.I114M|BPIFC_ENST00000300399.3_Missense_Mutation_p.I114M|BPIFC_ENST00000432451.2_De_novo_Start_OutOfFrame			Q8NFQ6	BPIL2_HUMAN	BPI fold containing family C							extracellular region	lipopolysaccharide binding|phospholipid binding										AGTCTGTGCTGATGTTGGCAG	0.443000													7	81					0	0	1	0	0
SSTR4	6754	broad.mit.edu	37	20	23016960	23016960	+	Silent	SNP	G	G	C			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr20:23016960G>C	ENST00000255008.3	+	1	904	c.840G>C	c.(838-840)ctG>ctC	p.L280L	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	280					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TGGTGCAGCTGCTGAACCTCT	0.572000													20	128					0	0	1	0	0
TNFRSF14	8764	broad.mit.edu	37	1	2492102	2492102	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:2492102C>T	ENST00000355716.4	+	5	799	c.500C>T	c.(499-501)cCg>cTg	p.P167L	TNFRSF14_ENST00000409119.1_Missense_Mutation_p.P167L	NM_003820.2	NP_003811.2	Q92956	TNR14_HUMAN	tumor necrosis factor receptor superfamily, member 14	167					immune response|interspecies interaction between organisms|T cell costimulation		tumor necrosis factor receptor activity			kidney(1)	1	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.1e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.02e-23)|GBM - Glioblastoma multiforme(42;1.11e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000326)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.199)		AACTGCCCCCCGGGGACCTTC	0.672000			"""Mis, N, F"""		follicular lymphoma								20	14					0	0	1	0	0
ABCD2	225	broad.mit.edu	37	12	40012651	40012651	+	Missense_Mutation	SNP	G	G	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:40012651G>T	ENST00000308666.3	-	1	902	c.767C>A	c.(766-768)cCc>cAc	p.P256H		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	256	ABC transmembrane type-1.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						TAGTAGGGTGGGCCCAATTGG	0.448000													55	51					1.39843e-22	1.59227e-22	1	1	0
FRG1B	0	broad.mit.edu	37	20	29625955	29625955	+	Nonsense_Mutation	SNP	A	A	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr20:29625955A>T	ENST00000278882.3	+	5	579	c.199A>T	c.(199-201)Aga>Tga	p.R67*	FRG1B_ENST00000358464.4_Nonsense_Mutation_p.R67*|FRG1B_ENST00000439954.2_Nonsense_Mutation_p.R72*																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATTGGACCAAGAGAACAATG	0.338000													7	95					0	0	1	0	0
TNKS	8658	broad.mit.edu	37	8	9588536	9588536	+	Missense_Mutation	SNP	A	A	C			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr8:9588536A>C	ENST00000310430.6	+	14	2164	c.2138A>C	c.(2137-2139)aAa>aCa	p.K713T	TNKS_ENST00000518281.1_Missense_Mutation_p.K476T	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	713					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		GTCCATGCCAAAGACAAGGGG	0.438000													7	31					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32029445	32029445	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr6:32029445C>A	ENST00000375244.3	-	21	7422	c.7221G>T	c.(7219-7221)gaG>gaT	p.E2407D	TNXB_ENST00000375247.2_Missense_Mutation_p.E2407D			P22105	TENX_HUMAN	tenascin XB	2467	Fibronectin type-III 16.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCTCAGGGGGCTCCGGGGCCT	0.657000													5	102					0.00116845	0.00121055	1	1	0
GRM7	2917	broad.mit.edu	37	3	7456839	7456839	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:7456839G>A	ENST00000486284.1	+	5	1437	c.1163G>A	c.(1162-1164)cGc>cAc	p.R388H	GRM7_ENST00000402647.2_Missense_Mutation_p.R388H|GRM7_ENST00000403881.1_Missense_Mutation_p.R388H|GRM7_ENST00000357716.4_Missense_Mutation_p.R388H|GRM7_ENST00000389336.4_Missense_Mutation_p.R388H	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	388					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding	p.R388P(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GACACAGATCGCAAATGCACA	0.423000													19	21					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51381707	51381707	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr19:51381707C>G	ENST00000325321.3	+	5	903	c.678C>G	c.(676-678)atC>atG	p.I226M	KLK2_ENST00000391810.2_Missense_Mutation_p.I124M|KLK2_ENST00000358049.4_3'UTR			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	226	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		TTCAAGGTATCACATCATGGG	0.532000			T	ETV4	prostate								54	103					0	0	1	0	0
PIK3C3	5289	broad.mit.edu	37	18	39573236	39573236	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr18:39573236C>G	ENST00000262039.4	+	7	803	c.717C>G	c.(715-717)gaC>gaG	p.D239E	PIK3C3_ENST00000398870.3_Missense_Mutation_p.D176E	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	239					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						TAATCTAGGACGGTGATGAAT	0.284000										TSP Lung(28;0.18)			6	31					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56490829	56490829	+	Splice_Site	SNP	C	C	T			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:56490829C>T	ENST00000267101.3	+	20	2715	c.2274_splice	c.e20-1	p.H759_splice	ERBB3_ENST00000553131.1_5'UTR|ERBB3_ENST00000450146.2_Splice_Site_p.H116_splice|ERBB3_ENST00000415288.2_Splice_Site_p.H700_splice	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	759	Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TGTCTCTTAGCATATGCTGGC	0.527000													35	39					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44075093	44075093	+	Silent	SNP	G	G	C			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:44075093G>C	ENST00000359947.4	+	22	4237	c.3897G>C	c.(3895-3897)tcG>tcC	p.S1299S	PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372413.3_Silent_p.S1290S|PTPRF_ENST00000422171.2_Silent_p.S647S|PTPRF_ENST00000372414.3_Silent_p.S1299S|PTPRF_ENST00000438120.1_Silent_p.S1290S	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1299					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATGAGCAGTCGATCGGACTGA	0.577000													5	32					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52715971	52715971	+	Missense_Mutation	SNP	C	C	G			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr19:52715971C>G	ENST00000322088.6	+	5	594	c.536C>G	c.(535-537)cCc>cGc	p.P179R	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.P124R|PPP2R1A_ENST00000462990.1_5'UTR	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	179	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.P179R(21)|p.P179L(5)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GATGACACCCCCATGGTGCGG	0.612000			Mis		clear cell ovarian carcinoma								13	38					0	0	1	0	0
GUSBP1	0	broad.mit.edu	37	5	21497311	21497311	+	RNA	SNP	C	C	T	rs138516990	by1000genomes	TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr5:21497311C>T	ENST00000607545.1	+	0	179					NR_027026.1																						ACCAGGTAAGCGGTGTTGAAC	0.537000													8	10					0	0	1	0	0
LIMK2	3985	broad.mit.edu	37	22	31658195	31658195	+	Silent	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr22:31658195G>A	ENST00000331728.4	+	6	741	c.627G>A	c.(625-627)ggG>ggA	p.G209G	LIMK2_ENST00000444929.2_Intron|LIMK2_ENST00000333611.4_Silent_p.G188G|LIMK2_ENST00000406516.1_Silent_p.G131G|LIMK2_ENST00000340552.4_Silent_p.G188G	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	209	PDZ.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						AGATCAATGGGACCCCCGTCC	0.557000													27	91					0	0	1	0	0
NARF	26502	broad.mit.edu	37	17	80445875	80445875	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr17:80445875G>A	ENST00000390006.4	+	11	1510	c.1036G>A	c.(1036-1038)Gct>Act	p.A346T	NARF_ENST00000345415.7_Missense_Mutation_p.A357T|NARF_ENST00000309794.10_Missense_Mutation_p.A405T|NARF_ENST00000457415.3_Missense_Mutation_p.A451T	NM_001038618.2	NP_001033707.1	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor	405						lamin filament	lamin binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			AGGCATTTACGCTGACATCCC	0.592000													10	51					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43002200	43002201	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:43002200_43002201delAG	ENST00000428554.2	+	9	1188_1189	c.45_46delAG	c.(43-48)aaagfs	p.KE15fs	CCDC30_ENST00000340612.4_Frame_Shift_Del_p.KE15fs|CCDC30_ENST00000342022.4_Frame_Shift_Del_p.KE15fs|CCDC30_ENST00000507855.1_Intron			Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	15										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(2)	30						AGTGGTCAAAAGAGAGAGAGAG	0.356													7	59	---	---	---	---					
RP11-86H7.1	0	broad.mit.edu	37	1	95273518	95273518	+	RNA	DEL	C	C	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:95273518delC	ENST00000452922.1	-	0	326																											atcagcctggccaatgtggtg	0.542													2	4	---	---	---	---					
SLAMF6	114836	broad.mit.edu	37	1	160466086	160466088	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:160466086_160466088delCTT	ENST00000368059.3	-	2	214_216	c.145_147delAAG	c.(145-147)del	p.K49del	SLAMF6_ENST00000368057.3_In_Frame_Del_p.K49del|SLAMF6_ENST00000368055.1_Intron	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	49						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			TGAAGTTGACCTTCTCTCCTGCA	0.458													96	194	---	---	---	---					
CTSE	1510	broad.mit.edu	37	1	206318413	206318414	+	Frame_Shift_Ins	INS	-	-	GA			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:206318413_206318414insGA	ENST00000361052.3	+	2	289_290	c.171_172insGA	c.(169-174)acagtcfs	p.V58fs	CTSE_ENST00000360218.2_Frame_Shift_Ins_p.V58fs|CTSE_ENST00000432969.2_Intron|CTSE_ENST00000358184.2_Frame_Shift_Ins_p.V58fs			P14091	CATE_HUMAN	cathepsin E	58					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			TCCAGTTCACCGAGTCCTGCTC	0.584													39	75	---	---	---	---					
SUSD4	55061	broad.mit.edu	37	1	223396671	223396671	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr1:223396671delG	ENST00000343846.3	-	7	1997	c.1364delC	c.(1363-1365)ctfs	p.P455fs	SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000454695.2_Frame_Shift_Del_p.P295fs|SUSD4_ENST00000366878.4_Frame_Shift_Del_p.P455fs			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	455						integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		GTCCGAAGCAGGGTGGGTGCT	0.587													13	120	---	---	---	---					
AC074391.1	0	broad.mit.edu	37	2	65894933	65894933	+	RNA	DEL	A	A	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:65894933delA	ENST00000377977.3	+	0	862																											TCAGAGGTTTAAAAAAAAAAA	0.517													3	3	---	---	---	---					
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	GACGGG	-	rs112040677		TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:131129929_131129934delGACGGG	ENST00000175756.5	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)cag>ca	p.QTG371del	PTPN18_ENST00000347849.3_In_Frame_Del_p.QTG264del	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	371						cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity	p.T378_G379delTG(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.777													2	4	---	---	---	---					
TANC1	85461	broad.mit.edu	37	2	160031574	160031598	+	Frame_Shift_Del	DEL	CAGAGACCTTCTGATAAAGGAGCCC	CAGAGACCTTCTGATAAAGGAGCCC	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:160031574_160031598delCAGAGACCTTCTGATAAAGGAGCCC	ENST00000263635.6	+	12	1851_1875	c.1614_1638delCAGAGACCTTCTGATAAAGGAGCCC	c.(1612-1638)tafs	p.YRDLLIKEP538fs	TANC1_ENST00000454300.1_Frame_Shift_Del_p.YRDLLIKEP432fs	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	538						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						TGGCCGCCTACAGAGACCTTCTGATAAAGGAGCCCCAACTACAGA	0.573													20	133	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217832850	217832850	+	RNA	DEL	C	C	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr2:217832850delC	ENST00000447289.1	+	0	510				AC007563.5_ENST00000607591.1_RNA																							ATGGGGCAGGCCCTGCAGGAA	0.557													2	4	---	---	---	---					
ATP2B2	491	broad.mit.edu	37	3	10452444	10452444	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr3:10452444delG	ENST00000397077.1	-	5	830	c.255delC	c.(253-255)aafs	p.N85fs	ATP2B2_ENST00000383800.4_Frame_Shift_Del_p.N85fs|ATP2B2_ENST00000360273.2_Frame_Shift_Del_p.N85fs|ATP2B2_ENST00000352432.4_Frame_Shift_Del_p.N85fs|ATP2B2_ENST00000343816.4_Frame_Shift_Del_p.N85fs			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	85					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GAGGTATAAAGTTTTGCCCAA	0.547													8	385	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68400387	68400387	+	RNA	DEL	C	C	-	rs111626719		TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr9:68400387delC	ENST00000417843.2	-	0	1432																											GATCTGGGGTCCTCTGATGAG	0.542													4	8	---	---	---	---					
FRMD3	257019	broad.mit.edu	37	9	85924485	85924485	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr9:85924485delA	ENST00000304195.3	-	10	1098	c.892delT	c.(892-894)ggfs	p.W298fs	FRMD3_ENST00000376438.1_Frame_Shift_Del_p.W298fs|FRMD3_ENST00000376434.1_Frame_Shift_Del_p.W104fs	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	298	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						CCACACTTCCAAAGATGTTTG	0.338													9	9	---	---	---	---					
MRVI1	10335	broad.mit.edu	37	11	10625994	10625996	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr11:10625994_10625996delCTC	ENST00000547195.1	-	12	1926_1928	c.1426_1428delGAG	c.(1426-1428)del	p.E476del	MRVI1_ENST00000527509.2_In_Frame_Del_p.E476del|LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000531107.1_In_Frame_Del_p.E559del|MRVI1_ENST00000558540.1_In_Frame_Del_p.E252del|MRVI1_ENST00000424001.1_In_Frame_Del_p.E252del|MRVI1_ENST00000552103.1_In_Frame_Del_p.E476del|MRVI1_ENST00000421747.1_In_Frame_Del_p.E558del|MRVI1_ENST00000534266.2_In_Frame_Del_p.E252del|MRVI1_ENST00000545852.1_In_Frame_Del_p.E252del|MRVI1_ENST00000436272.1_In_Frame_Del_p.E540del|MRVI1_ENST00000541483.1_In_Frame_Del_p.E361del|MRVI1_ENST00000423302.2_In_Frame_Del_p.E567del	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	540					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TCTCAGTGTTCTCCTCTGTCAGG	0.473													45	13	---	---	---	---					
C3AR1	719	broad.mit.edu	37	12	8211663	8211663	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr12:8211663delG	ENST00000307637.4	-	2	1322	c.1119delC	c.(1117-1119)agfs	p.S373fs		NM_004054.2	NP_004045.1	Q16581	C3AR_HUMAN	complement component 3a receptor 1	373					blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)	20				Kidney(36;0.0893)		GAAAGGTTTTGCTCTGAGACT	0.512													64	47	---	---	---	---					
RP11-67H24.2	0	broad.mit.edu	37	16	32823257	32823257	+	RNA	DEL	T	T	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr16:32823257delT	ENST00000569859.1	+	0	373																											CGGCGGCGGGTGGGTGGCAGA	0.731													2	4	---	---	---	---					
GHDC	84514	broad.mit.edu	37	17	40345560	40345562	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr17:40345560_40345562delGCA	ENST00000301671.8	-	2	479_481	c.38_40delTGC	c.(37-42)cca>c	p.LP13del	GHDC_ENST00000436923.2_In_Frame_Del_p.LP13del|GHDC_ENST00000414034.3_In_Frame_Del_p.LP13del|GHDC_ENST00000428494.2_In_Frame_Del_p.LP13del|GHDC_ENST00000587427.1_In_Frame_Del_p.LP13del|GHDC_ENST00000590520.1_5'UTR|GHDC_ENST00000593209.1_In_Frame_Del_p.LP13del			Q8N2G8	GHDC_HUMAN	GH3 domain containing	13						endoplasmic reticulum|nuclear envelope				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GCCAATGTTGgcagcagcagcag	0.631													2	4	---	---	---	---					
ZNF335	63925	broad.mit.edu	37	20	44592260	44592260	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr20:44592260delA	ENST00000322927.2	-	9	1485	c.1385delT	c.(1384-1386)tgfs	p.L462fs	ZNF335_ENST00000426788.1_Frame_Shift_Del_p.L307fs	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GAAGGGCCTCAAAAGTGGTTT	0.577													30	308	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11055420	11055420	+	RNA	DEL	G	G	-			TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr21:11055420delG	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		cacagctactgctctgccctt	0.308													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11064287	11064288	+	RNA	INS	-	-	A	rs55767427		TCGA-N5-A59E-01A-11D-A28R-08	TCGA-N5-A59E-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a1c40f05-739b-47fb-8438-96d08cb942a3	5d62f932-3092-433a-801e-cb91dcc91ee2	g.chr21:11064287_11064288insA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCTTCCACAGCAATCTTTCTAA	0.416													4	6	---	---	---	---					
