feature type start end label R G B shape direction protein Name=TP53; Synonyms=P53; 1 393 Name=TP53; Synonyms=P53; 0.7 0.9 0.9 - - domain DNA-binding (experimentally determined) 102 292 DNA-binding (experimentally determined) 0.49 0.5 0.38 - - domain Interaction with CCAR2. {ECO:0000269|PubMed:25732823}. 1 320 Interaction with CCAR2. {ECO:0000269|PubMed:25732823}. 0.62 0.69 0.56 - - domain Interaction with HRMT1L2. {ECO:0000269|PubMed:15186775}. 1 83 Interaction with HRMT1L2. {ECO:0000269|PubMed:15186775}. 0.27 0.45 0.61 - - domain Transcription activation (acidic). 1 44 Transcription activation (acidic). 0.68 0.7 0.24 - - domain Interaction with WWOX. 66 110 Interaction with WWOX. 0.33 0.29 0.21 - - domain Interaction with HIPK1. {ECO:0000250}. 100 370 Interaction with HIPK1. {ECO:0000250}. 0.3 0.65 0.2 - - domain Required for interaction with ZNF385A. {ECO:0000269|PubMed:17719541}. 100 300 Required for interaction with ZNF385A. {ECO:0000269|PubMed:17719541}. 0.5 0.28 0.65 - - domain Required for interaction with FBXO42. {ECO:0000269|PubMed:19509332}. 113 236 Required for interaction with FBXO42. {ECO:0000269|PubMed:19509332}. 0.58 0.23 0.34 - - domain Interaction with AXIN1. {ECO:0000250}. 116 292 Interaction with AXIN1. {ECO:0000250}. 0.32 0.75 0.75 - - domain Interaction with the 53BP2 SH3 domain. 241 248 Interaction with the 53BP2 SH3 domain. 0.77 0.43 0.78 - - domain Interaction with E4F1. {ECO:0000269|PubMed:10644996}. 256 294 Interaction with E4F1. {ECO:0000269|PubMed:10644996}. 0.8 0.42 0.3 - - domain Interaction with DNA. 273 280 Interaction with DNA. 0.23 0.76 0.46 - - domain Interaction with CARM1. {ECO:0000269|PubMed:15186775}. 300 393 Interaction with CARM1. {ECO:0000269|PubMed:15186775}. 0.77 0.2 0.55 - - domain Interaction with HIPK2. 319 360 Interaction with HIPK2. 0.96 0 0.76 - - domain Oligomerization. 325 356 Oligomerization. 0.69 0 0.93 - - domain Interaction with USP7. 359 363 Interaction with USP7. 0 0.96 0.89 - - domain Basic (repression of DNA-binding). 368 387 Basic (repression of DNA-binding). 0.23 0.23 0.79 - - domain TADI. 17 25 TADI. 0.95 0.77 0 - - domain TADII. 48 56 TADII. 0 0.92 0.6 - - domain Bipartite nuclear localization signal. 305 321 Bipartite nuclear localization signal. 0.66 0.93 0 - - domain Nuclear export signal. 339 350 Nuclear export signal. 0 0.65 0.89 - - domain [KR]-[STA]-K motif. 370 372 [KR]-[STA]-K motif. 0 0.62 0.6 - - mutation Frame_Shift_Del 349 349 p.E349fs 1.0 0.0 0.0 square up mutation Nonsense_Mutation 349 349 p.E349* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 342 342 p.R342* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 339 339 p.E339* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 339 339 p.E339* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 337 337 p.R337L 1.0 1.0 0.0 circle up mutation Missense_Mutation 337 337 p.R337P 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 331 331 p.Q331* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 306 306 p.R306* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 286 286 p.E286* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 285 285 p.E285D 1.0 1.0 0.0 circle up mutation Missense_Mutation 285 285 p.E285K 1.0 1.0 0.0 circle up mutation Missense_Mutation 284 284 p.T284P 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 283 283 p.R283fs 1.0 0.0 0.0 square up mutation Missense_Mutation 282 282 p.R282P 1.0 1.0 0.0 circle up mutation Missense_Mutation 280 280 p.R280K 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 280 280 p.R280fs 1.0 0.0 0.0 square up mutation Silent 279 279 p.G279G 0.8 0.8 0.8 circle up mutation Missense_Mutation 279 279 p.G279E 1.0 1.0 0.0 circle up mutation Missense_Mutation 278 278 p.P278R 1.0 1.0 0.0 circle up mutation Missense_Mutation 276 276 p.A276G 1.0 1.0 0.0 circle up mutation Missense_Mutation 275 275 p.C275Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 275 275 p.C275Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 274 274 p.V274F 1.0 1.0 0.0 circle up mutation Missense_Mutation 274 274 p.V274F 1.0 1.0 0.0 circle up mutation Missense_Mutation 273 273 p.R273L 1.0 1.0 0.0 circle up mutation Missense_Mutation 273 273 p.R273L 1.0 1.0 0.0 circle up mutation Missense_Mutation 273 273 p.R273P 1.0 1.0 0.0 circle up mutation Missense_Mutation 273 273 p.R273C 1.0 1.0 0.0 circle up mutation Missense_Mutation 272 272 p.V272L 1.0 1.0 0.0 circle up mutation Missense_Mutation 272 272 p.V272L 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 271 271 p.E271* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 267 267 p.R267P 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 266 266 p.G266* 1.0 0.0 0.0 triangle up mutation Silent 265 265 p.L265L 0.8 0.8 0.8 circle up mutation Missense_Mutation 254 254 p.I254N 1.0 1.0 0.0 circle up mutation Missense_Mutation 249 249 p.R249S 1.0 1.0 0.0 circle up mutation Missense_Mutation 249 249 p.R249S 1.0 1.0 0.0 circle up mutation Missense_Mutation 248 248 p.R248Q 1.0 1.0 0.0 circle up mutation Missense_Mutation 248 248 p.R248L 1.0 1.0 0.0 circle up mutation Missense_Mutation 245 245 p.G245D 1.0 1.0 0.0 circle up mutation Missense_Mutation 245 245 p.G245V 1.0 1.0 0.0 circle up mutation Missense_Mutation 245 245 p.G245C 1.0 1.0 0.0 circle up mutation Missense_Mutation 245 245 p.G245R 1.0 1.0 0.0 circle up mutation Missense_Mutation 244 244 p.G244C 1.0 1.0 0.0 circle up mutation Missense_Mutation 240 240 p.S240R 1.0 1.0 0.0 circle up mutation Missense_Mutation 234 234 p.Y234C 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 221 221 p.E221* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 220 220 p.Y220C 1.0 1.0 0.0 circle up mutation Missense_Mutation 220 220 p.Y220C 1.0 1.0 0.0 circle up mutation Missense_Mutation 213 213 p.R213L 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 213 213 p.R213* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 205 205 p.Y205F 1.0 1.0 0.0 circle up mutation Missense_Mutation 205 205 p.Y205C 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 204 204 p.E204* 1.0 0.0 0.0 triangle up mutation In_Frame_Del 201 201 p.LR201del 0.0 0.0 1.0 square up mutation Missense_Mutation 195 195 p.I195T 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 188 188 p.L188fs 1.0 0.0 0.0 square up mutation Nonsense_Mutation 180 180 p.E180* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 180 180 p.E180* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 179 179 p.H179R 1.0 1.0 0.0 circle up mutation Missense_Mutation 179 179 p.H179R 1.0 1.0 0.0 circle up mutation Missense_Mutation 179 179 p.H179R 1.0 1.0 0.0 circle up mutation Missense_Mutation 179 179 p.H179R 1.0 1.0 0.0 circle up mutation Missense_Mutation 179 179 p.H179R 1.0 1.0 0.0 circle up mutation Missense_Mutation 179 179 p.H179Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 179 179 p.H179N 1.0 1.0 0.0 circle up mutation Missense_Mutation 179 179 p.H179Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 176 176 p.C176W 1.0 1.0 0.0 circle up mutation Missense_Mutation 176 176 p.C176Y 1.0 1.0 0.0 circle up mutation Missense_Mutation 175 175 p.R175H 1.0 1.0 0.0 circle up mutation Missense_Mutation 175 175 p.R175H 1.0 1.0 0.0 circle up mutation Missense_Mutation 175 175 p.R175H 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 164 164 p.K164* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 163 163 p.Y163C 1.0 1.0 0.0 circle up mutation Missense_Mutation 161 161 p.A161T 1.0 1.0 0.0 circle up mutation Missense_Mutation 158 158 p.R158P 1.0 1.0 0.0 circle up mutation Missense_Mutation 158 158 p.R158L 1.0 1.0 0.0 circle up mutation Missense_Mutation 158 158 p.R158P 1.0 1.0 0.0 circle up mutation Missense_Mutation 158 158 p.R158L 1.0 1.0 0.0 circle up mutation In_Frame_Ins 157 157 p.157_158insV 0.0 0.0 1.0 square up mutation Missense_Mutation 157 157 p.V157F 1.0 1.0 0.0 circle up mutation Missense_Mutation 157 157 p.V157F 1.0 1.0 0.0 circle up mutation Missense_Mutation 154 154 p.G154V 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 154 154 p.G154fs 1.0 0.0 0.0 square up mutation Frame_Shift_Del 153 153 p.P153fs 1.0 0.0 0.0 square up mutation Frame_Shift_Del 143 143 p.V143fs 1.0 0.0 0.0 square up mutation Missense_Mutation 151 151 p.P151S 1.0 1.0 0.0 circle up mutation Missense_Mutation 148 148 p.D148H 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 147 147 p.V147fs 1.0 0.0 0.0 square up mutation Missense_Mutation 138 138 p.A138P 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 136 136 p.Q136* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 132 132 p.K132* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 131 131 p.N131I 1.0 1.0 0.0 circle up mutation Missense_Mutation 130 130 p.L130V 1.0 1.0 0.0 circle up mutation Splice_Site 125 125 p.T125T 0.6 0.0 0.6 inv_triangle up mutation Missense_Mutation 120 120 p.K120Q 1.0 1.0 0.0 circle up mutation Nonsense_Mutation 107 107 p.Y107* 1.0 0.0 0.0 triangle up mutation Missense_Mutation 105 105 p.G105R 1.0 1.0 0.0 circle up mutation Frame_Shift_Del 93 93 p.L93fs 1.0 0.0 0.0 square up mutation Frame_Shift_Del 91 91 p.W91fs 1.0 0.0 0.0 square up mutation Frame_Shift_Del 85 85 p.P85fs 1.0 0.0 0.0 square up mutation Frame_Shift_Del 84 84 p.A84fs 1.0 0.0 0.0 square up mutation Nonsense_Mutation 68 68 p.E68* 1.0 0.0 0.0 triangle up mutation Frame_Shift_Del 58 58 p.P58fs 1.0 0.0 0.0 square up mutation Nonsense_Mutation 56 56 p.E56* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 53 53 p.W53* 1.0 0.0 0.0 triangle up mutation Nonsense_Mutation 53 53 p.W53* 1.0 0.0 0.0 triangle up mutation Frame_Shift_Del 35 35 p.L35fs 1.0 0.0 0.0 square up