Conservation (pFN) = Probability that mutations within

this gene occur disproportionately at evolutionarily

conserved sites. Sites highly conserved across

vertebrates are assumed to have greater functional

q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)

This figure depicts the distribution of mutations and mutation types across the TP53 significant gene.

This figure depicts the distribution of mutations and mutation types across the CDKN2A significant gene.

This figure depicts the distribution of mutations and mutation types across the PTEN significant gene.

This figure depicts the distribution of mutations and mutation types across the KEAP1 significant gene.

This figure depicts the distribution of mutations and mutation types across the NOTCH1 significant gene.

This figure depicts the distribution of mutations and mutation types across the NFE2L2 significant gene.

This figure depicts the distribution of mutations and mutation types across the CUL3 significant gene.

This figure depicts the distribution of mutations and mutation types across the ARID1A significant gene.

This figure depicts the distribution of mutations and mutation types across the NF1 significant gene.

This figure depicts the distribution of mutations and mutation types across the RANBP2 significant gene.

A Ranked List of Significantly Mutated Genes. Number of significant genes found: 10. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).

MutSig and its evolving algorithms have existed since
                    the youth of clinical sequencing, with early versions
                    used in multiple publications.

"Three significance metrics [are] calculated for each
                    gene, using the [&hellip;] methods MutSigCV

Getz G, H&ouml;fling H, Mesirov JP, Golub TR, Meyerson M, Tibshirani R, Lander ES

Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"